Detailed information for compound 1192860

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 408.941 | Formula: C21H30ClFN4O
  • H donors: 3 H acceptors: 1 LogP: 3.11 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)CCNCCO[C@@H]1CNC[C@H]1Cc1cc(C)cc(n1)N.Cl
  • InChi: 1S/C21H29FN4O.ClH/c1-15-9-19(26-21(23)10-15)12-17-13-25-14-20(17)27-8-7-24-6-5-16-3-2-4-18(22)11-16;/h2-4,9-11,17,20,24-25H,5-8,12-14H2,1H3,(H2,23,26);1H/t17-,20-;/m1./s1
  • InChiKey: IAFWSKDSYUFBEI-OGPPPPIKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.001 0.001
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.001 0.001
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0348 0.0348
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.001 0.001
Brugia malayi Animal haem peroxidase family protein 0.0662 1 1
Toxoplasma gondii exonuclease III APE 0.0059 0.071 0.2637
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0013 0.001 0.001
Onchocerca volvulus Peroxidasin homolog 0.0662 1 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0013 0.001 0.001
Echinococcus granulosus neural cadherin 0.0148 0.2088 0.2088
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0569 0.5512
Mycobacterium ulcerans lipase LipD 0.0078 0.1013 0.3764
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Brugia malayi Calcium binding EGF domain containing protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) TAR-binding protein 0.0127 0.1761 0.1761
Brugia malayi Delta serrate ligand family protein 0.0148 0.2088 0.2088
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0096 0.1278 0.1278
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1322 0.1322
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus multilocularis neural cadherin 0.0148 0.2088 0.2088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1322 0.1322
Schistosoma mansoni cpg binding protein 0.0033 0.0318 0.0318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1322 0.1322
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0163 0.0163
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.1322 0.1322
Onchocerca volvulus 0.0013 0.001 0.001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.1761 0.1761
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.001 0.001
Mycobacterium leprae conserved hypothetical protein 0.0078 0.1013 0.5247
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.1013 0.1013
Echinococcus granulosus intermediate filament protein 0.0061 0.074 0.074
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Brugia malayi ecdysteroid receptor 0.0023 0.0163 0.0163
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0721 0.2678
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.001 0.001
Echinococcus granulosus protein jagged 2 0.0148 0.2088 0.2088
Echinococcus granulosus mothers against decapentaplegic 6 0.0016 0.005 0.005
Brugia malayi Muscleblind-like protein 0.0163 0.2314 0.2314
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Brugia malayi EGF-like domain containing protein 0.0148 0.2088 0.2088
Schistosoma mansoni coup transcription factor 0.0023 0.0163 0.0163
Echinococcus granulosus alpha 1A adrenergic receptor 0.0013 0.001 0.001
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0096 0.1278 0.1278
Echinococcus granulosus g protein coupled receptor 0.0013 0.001 0.001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0163 0.0163
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.001 0.001
Echinococcus multilocularis neuropeptide s receptor 0.0013 0.001 0.001
Brugia malayi nuclear receptor NHR-88 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) animal heme peroxidase 0.0662 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.001 0.001
Onchocerca volvulus 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.4155 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1761 0.1761
Echinococcus multilocularis tar DNA binding protein 0.0127 0.1761 0.1761
Echinococcus multilocularis protein jagged 1 0.0148 0.2088 0.2088
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.029 0.029
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1013 0.2439
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0163 0.0163
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0096 0.1278 0.1278
Toxoplasma gondii Erv1 / Alr family protein 0.0013 0.0003 0.0011
Echinococcus granulosus tar DNA binding protein 0.0127 0.1761 0.1761
Echinococcus granulosus allatostatin A receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Brugia malayi hypothetical protein 0.0013 0.001 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0187 0.2692 0.2692
Onchocerca volvulus 0.0148 0.2088 0.2088
Schistosoma mansoni intermediate filament proteins 0.0061 0.074 0.074
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0569 0.2114
Echinococcus granulosus fibropellin Ia 0.0148 0.2088 0.2088
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0013 0.001 0.001
Brugia malayi beta-lactamase family protein 0.0078 0.1013 0.1013
Toxoplasma gondii Erv1 / Alr family protein 0.008 0.1032 0.3835
Brugia malayi MH2 domain containing protein 0.0016 0.005 0.005
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.015 0.015
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.1013 0.135
Echinococcus multilocularis G protein coupled receptor 139 0.0013 0.001 0.001
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0029 0.0258 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.001 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1013 0.1013
Brugia malayi RNA binding protein 0.0127 0.1761 0.1761
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.071 0.071
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus multilocularis sulfhydryl oxidase 1 0.0013 0.0003 0.0003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.05 0.7507 1
Brugia malayi MH1 domain containing protein 0.0019 0.0107 0.0107
Loa Loa (eye worm) Erv1/Alr family protein 0.0013 0.0003 0.0003
Echinococcus multilocularis Smad4 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Echinococcus granulosus fmrfamide receptor 0.0013 0.001 0.001
Brugia malayi Peroxidasin 0.0662 1 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0013 0.001 0.001
Echinococcus multilocularis muscleblind protein 0.0163 0.2314 0.2314
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1761 0.1761
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0013 0.001 0.001
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0013 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.001 0.001
Brugia malayi MH2 domain containing protein 0.0035 0.0348 0.0348
Brugia malayi EGF-like domain containing protein 0.0148 0.2088 0.2088
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0569 0.5512
Schistosoma mansoni notch 0.0148 0.2088 0.2088
Echinococcus granulosus neuropeptide receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.071 0.071
Brugia malayi hypothetical protein 0.0013 0.001 0.001
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0163 0.0163
Toxoplasma gondii aldehyde dehydrogenase 0.0187 0.2692 1
Brugia malayi hypothetical protein 0.0032 0.0299 0.0299
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0163 0.0163
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0163 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1013 0.2439
Echinococcus multilocularis serotonin receptor 0.0013 0.001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0569 0.5512
Echinococcus multilocularis fmrfamide receptor 0.0013 0.001 0.001
Echinococcus multilocularis neurogenic locus notch protein 4 0.0148 0.2088 0.2088
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.071 0.1709
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0121 0.1675 0.1675
Echinococcus granulosus muscleblind protein 0.0163 0.2314 0.2314
Brugia malayi hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Brugia malayi putative neuropeptide receptor NPR1 0.0013 0.001 0.001
Brugia malayi G protein-coupled receptor F59B2.13 0.0013 0.001 0.001
Onchocerca volvulus 0.0013 0.001 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0078 0.1013 0.1013
Loa Loa (eye worm) quiescin Q6 0.0013 0.0003 0.0003
Brugia malayi neuropeptide F receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0059 0.0723 0.0723
Brugia malayi Calcium binding EGF domain containing protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) RNA binding protein 0.0127 0.1761 0.1761
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0029 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus neuropeptide receptor A26 0.0013 0.001 0.001
Treponema pallidum fructose-bisphosphate aldolase 0.0282 0.4155 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0107
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0163 0.0163
Schistosoma mansoni cpg binding protein 0.0031 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus neurogenic locus notch protein 0.0148 0.2088 0.2088
Brugia malayi G-protein coupled receptor 0.0013 0.001 0.001
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0013 0.001 0.001
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1013 0.1013
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus neuropeptide s receptor 0.0013 0.001 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0187 0.2692 0.2692
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.008 0.1032 0.1032
Loa Loa (eye worm) hypothetical protein 0.0163 0.2314 0.2314
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus multilocularis lamin dm0 0.0061 0.074 0.074
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0187 0.2692 0.2692
Brugia malayi hypothetical protein 0.0013 0.001 0.001
Brugia malayi hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) Smad1 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0013 0.001 0.001
Leishmania major hypothetical protein, conserved 0.0078 0.1013 0.3764
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.071 0.071
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.001 0.001
Echinococcus granulosus tachykinin peptides receptor 99D 0.0013 0.001 0.001
Schistosoma mansoni neuropeptide f receptor 76f 0.0013 0.001 0.001
Echinococcus multilocularis orexin receptor type 2 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus multilocularis protein jagged 2 0.0148 0.2088 0.2088
Echinococcus multilocularis smad 0.0035 0.0348 0.0348
Brugia malayi MH2 domain containing protein 0.0035 0.0348 0.0348
Echinococcus granulosus lamin dm0 0.0061 0.074 0.074
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.001 0.001
Echinococcus multilocularis cpg binding protein 0.0033 0.0318 0.0318
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.1013 0.135
Brugia malayi Muscle positioning protein 4 0.0148 0.2088 0.2088
Schistosoma mansoni hypothetical protein 0.0148 0.2088 0.2088
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0013 0.001 0.001
Loa Loa (eye worm) TYRA-2 protein 0.0013 0.001 0.001
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1931 0.7174
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0163 0.0163
Schistosoma mansoni neuropeptide receptor 0.0013 0.001 0.001
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.001 0.001
Onchocerca volvulus 0.0013 0.001 0.001
Echinococcus multilocularis g-protein coupled receptor 0.0013 0.001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0187 0.2692 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0163 0.0163
Brugia malayi G protein-coupled receptor 0.0013 0.001 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0163 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.001 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.001 0.001
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0013 0.0003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0028 0.0241 0.0241
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0013 0.0003 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0121 0.1675 0.1675
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.001 0.001
Brugia malayi GCC2 and GCC3 family protein 0.0148 0.2088 0.2088
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0163 0.0163
Echinococcus granulosus cpg binding protein 0.0033 0.0318 0.0318
Brugia malayi sulfakinin receptor protein 0.0013 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1322 0.1322
Mycobacterium ulcerans beta-lactamase 0.0078 0.1013 0.3764
Loa Loa (eye worm) latrophilin receptor protein 2 0.0121 0.1675 0.1675
Schistosoma mansoni smad 0.0035 0.0348 0.0348
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0163 0.0163
Onchocerca volvulus 0.0013 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0148 0.2088 0.2088
Schistosoma mansoni histamine h1 receptor 0.0013 0.001 0.001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0187 0.2692 1
Schistosoma mansoni neuropeptide receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0148 0.2088 0.2088
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0163 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0121 0.1675 0.1675
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Echinococcus granulosus neurogenic locus notch protein 0.0148 0.2088 0.2088
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1931 0.2573
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0163 0.0163
Echinococcus granulosus sulfhydryl oxidase 1 0.0013 0.0003 0.0003
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0029 0.0258 0.0258
Onchocerca volvulus 0.0013 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0148 0.2088 0.2088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1013 0.9817
Onchocerca volvulus Neuropeptide F receptor homolog 0.0013 0.001 0.001
Brugia malayi Melatonin receptor type 1A 0.0013 0.001 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0121 0.1675 0.1675
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0163 0.0163
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0348 0.0348
Schistosoma mansoni hypothetical protein 0.0148 0.2088 0.2088
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0013 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0262 0.3842 0.3842
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0013 0.001 0.001
Echinococcus granulosus smad 0.0035 0.0348 0.0348
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1931 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.001 0.001
Onchocerca volvulus 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0163 0.0163
Echinococcus granulosus sex peptide receptor 0.0013 0.001 0.001
Echinococcus granulosus delta-like protein 1 0.0148 0.2088 0.2088
Brugia malayi nuclear hormone receptor 0.0023 0.0163 0.0163
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.001 0.001
Schistosoma mansoni biogenic amine receptor 0.0013 0.001 0.001
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0163 0.0163
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0163 0.0163
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1013 0.9817
Echinococcus multilocularis slit 2 protein 0.0148 0.2088 0.2088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.4155 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0013 0.001 0.001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.4155 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.071 0.1709
Echinococcus granulosus Smad4 0.0035 0.0348 0.0348
Brugia malayi Animal haem peroxidase family protein 0.0662 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.071 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0061 0.074 0.074
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0569 0.5512
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0013 0.001 0.001
Echinococcus granulosus g protein coupled receptor 0.0013 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.4155 1
Brugia malayi G-protein coupled receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Brugia malayi putative neuropeptide receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hepatopoietin HPO2 0.008 0.1032 0.1032
Echinococcus granulosus neurogenic locus protein delta 0.0148 0.2088 0.2088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0163 0.0163
Onchocerca volvulus 0.0061 0.074 0.074
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0061 0.074 0.074
Schistosoma mansoni smad 0.0016 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0163 0.0163
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.071 0.0945
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0013 0.001 0.001
Onchocerca volvulus 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus multilocularis fat cadherin tumor suppressor 0.0148 0.2088 0.2088
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.1013 0.135
Loa Loa (eye worm) hypothetical protein 0.0078 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Schistosoma mansoni opsin-like receptor 0.0013 0.001 0.001
Brugia malayi larval opioid receptor 0.0013 0.001 0.001
Schistosoma mansoni Smad4 0.0016 0.005 0.005
Onchocerca volvulus 0.0013 0.001 0.001
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0096 0.1278 0.1278
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.071 0.2637
Schistosoma mansoni laminin gamma-3 chain 0.0148 0.2088 0.2088
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0163 0.0163
Brugia malayi Calcitonin receptor-like protein seb-1 0.0383 0.5709 0.5709
Echinococcus granulosus G protein coupled receptor 139 0.0013 0.001 0.001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.1013 0.135
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0187 0.2692 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0013 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1013 0.2439
Schistosoma mansoni hypothetical protein 0.0148 0.2088 0.2088
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.008 0.1032 0.1032
Onchocerca volvulus Slit protein homolog 0.0148 0.2088 0.2088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.1013 0.3764
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0013 0.001 0.001
Echinococcus multilocularis neuropeptide receptor 0.0013 0.001 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.1013 0.3764
Schistosoma mansoni amine GPCR 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.1013 0.135
Loa Loa (eye worm) hypothetical protein 0.0049 0.0569 0.0569
Echinococcus multilocularis sex peptide receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.008 0.1032 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.001 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.1761 0.1761
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1761 0.1761
Schistosoma mansoni notch 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0569 0.5512
Toxoplasma gondii EGF family domain-containing protein 0.0148 0.2088 0.7756
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.4155 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0383 0.5709 0.5709
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Brugia malayi EGF-like domain containing protein 0.0148 0.2088 0.2088
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0013 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.071 0.6876
Echinococcus multilocularis allatostatin A receptor 0.0013 0.001 0.001
Echinococcus multilocularis neurogenic locus protein delta 0.0148 0.2088 0.2088
Brugia malayi Augmenter of liver regeneration 0.008 0.1032 0.1032
Brugia malayi latrophilin 2 splice variant baaae 0.0262 0.3842 0.3842
Echinococcus multilocularis GPCR, family 2 0.0121 0.1675 0.1675
Echinococcus multilocularis lamin 0.0061 0.074 0.074
Mycobacterium ulcerans hypothetical protein 0.0078 0.1013 0.3764
Schistosoma mansoni hypothetical protein 0.0121 0.1675 0.1675
Onchocerca volvulus Chorion peroxidase homolog 0.0662 1 1
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0163 0.0163
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.1013 0.135
Echinococcus granulosus neurogenic locus notch protein 4 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.071 0.6876
Brugia malayi mothers against decapentaplegic homolog 3 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0262 0.3842 0.3842
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0163 0.0163
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.071 0.6876
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0163 0.0163
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.4155 1
Schistosoma mansoni hypothetical protein 0.0121 0.1675 0.1675
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.001 0.001
Echinococcus multilocularis g protein coupled receptor 0.0013 0.001 0.001
Echinococcus granulosus peptide allatostatin:somatostatin 0.0013 0.001 0.001
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0013 0.001 0.001
Onchocerca volvulus 0.0662 1 1
Echinococcus granulosus slit 2 protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Echinococcus granulosus g protein coupled receptor 0.0013 0.001 0.001
Echinococcus multilocularis fmrfamide receptor 0.0013 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0163 0.0163
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0013 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0022 0.015 0.015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0163 0.0163
Schistosoma mansoni smad1 5 8 and 0.0035 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.005
Onchocerca volvulus 0.0031 0.029 0.029
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.1013 0.135
Echinococcus granulosus protein jagged 1 0.0148 0.2088 0.2088
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0163 0.0163
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.008 0.1032 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Brugia malayi hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Schistosoma mansoni hypothetical protein 0.0544 0.8184 0.8184
Schistosoma mansoni biogenic amine (5HT) receptor 0.0013 0.001 0.001
Echinococcus multilocularis somatostatin receptor 0.0013 0.001 0.001
Schistosoma mansoni neuropeptide receptor 0.0013 0.001 0.001
Brugia malayi EGF-like domain containing protein 0.0148 0.2088 0.2088
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0163 0.0163
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0013 0.001 0.001
Brugia malayi Dopamine receptor protein 2 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.083 0.083
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0163 0.0163
Echinococcus granulosus geminin 0.0544 0.8184 0.8184
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0282 0.4155 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.001 0.001
Echinococcus granulosus hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus mothers against decapentaplegic 2 0.0016 0.005 0.005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.071 0.071
Schistosoma mansoni hypothetical protein 0.0544 0.8184 0.8184
Onchocerca volvulus 0.0662 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.1013 0.1013
Schistosoma mansoni hypothetical protein 0.0096 0.1278 0.1278
Schistosoma mansoni lamin 0.0061 0.074 0.074
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0308 0.0308
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1013 0.2439
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0096 0.1278 0.1278
Brugia malayi CXXC zinc finger family protein 0.0031 0.029 0.029
Giardia lamblia Fructose-bisphosphate aldolase 0.0282 0.4155 1
Brugia malayi hypothetical protein 0.0013 0.001 0.001
Brugia malayi TAR-binding protein 0.0127 0.1761 0.1761
Schistosoma mansoni growth hormone secretagogue receptor 0.0013 0.001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0187 0.2692 1
Brugia malayi hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0348 0.0348
Schistosoma mansoni adenoreceptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0121 0.1675 0.1675
Toxoplasma gondii ABC1 family protein 0.0078 0.1013 0.3764
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Onchocerca volvulus 0.0013 0.001 0.001
Echinococcus multilocularis g protein coupled receptor 0.0013 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0163 0.0163
Echinococcus multilocularis mothers against decapentaplegic 2 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0163 0.2314 0.2314
Schistosoma mansoni peroxidasin 0.0662 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0013 0.001 0.001
Onchocerca volvulus 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus biogenic amine 5HT receptor 0.0013 0.001 0.001
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0148 0.2088 0.2088
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0096 0.1278 0.1278
Brugia malayi MH1 domain containing protein 0.0019 0.0107 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1761 0.1761
Loa Loa (eye worm) hypothetical protein 0.0078 0.1013 0.1013
Leishmania major hypothetical protein, conserved 0.008 0.1032 0.3835
Loa Loa (eye worm) hypothetical protein 0.0078 0.1013 0.1013
Onchocerca volvulus 0.0013 0.001 0.001
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0013 0.001 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) animal heme peroxidase 0.0662 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.1322 0.1322
Brugia malayi Serotonin receptor 0.0013 0.001 0.001
Onchocerca volvulus 0.0078 0.1013 0.1013
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.1013 0.9817
Brugia malayi Blistered cuticle protein 3 0.0662 1 1
Leishmania major hypothetical protein, conserved 0.0049 0.0569 0.2114
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0163 0.0163
Brugia malayi RE15519p 0.0013 0.001 0.001
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0013 0.001 0.001
Mycobacterium tuberculosis Conserved protein 0.0078 0.1013 0.135
Echinococcus granulosus g-protein coupled receptor 0.0013 0.001 0.001
Brugia malayi beta-lactamase 0.0078 0.1013 0.1013
Trichomonas vaginalis esterase, putative 0.0078 0.1013 0.2439
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0348 0.0348
Loa Loa (eye worm) nuclear factor I 0.0019 0.0107 0.0107
Brugia malayi steroid hormone receptor 0.0023 0.0163 0.0163
Giardia lamblia High cysteine protein 0.0148 0.2088 0.5026
Schistosoma mansoni hypothetical protein 0.0096 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.001 0.001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.1322 0.1322
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0515 0.7729 0.7729
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0163 0.0163
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.008 0.1032 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.001 0.001
Schistosoma mansoni opsin-like receptor 0.0013 0.001 0.001
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.008 0.1032 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Brugia malayi Calcium binding EGF domain containing protein 0.0148 0.2088 0.2088
Echinococcus multilocularis g protein coupled receptor 0.0013 0.001 0.001
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0013 0.0003 0.0003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.1322 0.1322
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0013 0.001 0.001
Loa Loa (eye worm) Notch2 0.0148 0.2088 0.2088
Mycobacterium tuberculosis Conserved protein 0.0078 0.1013 0.135
Loa Loa (eye worm) apoptosis regulator protein 0.0096 0.1278 0.1278
Brugia malayi Animal haem peroxidase family protein 0.0662 1 1
Echinococcus granulosus serotonin receptor 0.0013 0.001 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.001 0.001
Brugia malayi intermediate filament protein 0.0061 0.074 0.074
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0003 0.0029
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0148 0.2088 0.2088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.001 0.001
Schistosoma mansoni slit 0.0148 0.2088 0.2088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0013 0.001 0.001
Onchocerca volvulus Peroxidasin homolog 0.0662 1 1
Onchocerca volvulus Dual oxidase homolog 0.0662 1 1
Brugia malayi Cadherin domain containing protein 0.0148 0.2088 0.2088
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.1013 0.1013
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0013 0.001 0.001
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0013 0.001 0.001
Schistosoma mansoni biogenic amine receptor 0.0013 0.001 0.001
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0013 0.001 0.001
Echinococcus multilocularis musashi 0.0061 0.074 0.074
Brugia malayi Erv1 / Alr family protein 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0061 0.074 0.074
Echinococcus multilocularis mothers against decapentaplegic 6 0.0016 0.005 0.005
Echinococcus multilocularis fibropellin Ia 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Onchocerca volvulus 0.0148 0.2088 0.2088
Brugia malayi ORL1-like opioid receptor 0.0013 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.4155 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0348 0.0348
Loa Loa (eye worm) notch protein 0.0148 0.2088 0.2088
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0013 0.001 0.001
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0348 0.0348
Echinococcus multilocularis peroxidasin 0.0662 1 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0013 0.001 0.001
Schistosoma mansoni amine GPCR 0.0013 0.001 0.001
Echinococcus granulosus orexin receptor type 2 0.0013 0.001 0.001
Echinococcus granulosus protein jagged 2 0.0148 0.2088 0.2088
Schistosoma mansoni cpg binding protein 0.0033 0.0318 0.0318
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0013 0.001 0.001
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.008 0.1032 1
Onchocerca volvulus 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Schistosoma mansoni amine GPCR 0.0013 0.001 0.001
Schistosoma mansoni biogenic amine receptor 0.0013 0.001 0.001
Brugia malayi follicle stimulating hormone receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0383 0.5709 0.5709
Echinococcus granulosus neuropeptide receptor 0.0013 0.001 0.001
Schistosoma mansoni apoptosis regulator bax 0.0096 0.1278 0.1278
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0163 0.0163
Echinococcus multilocularis muscleblind protein 1 0.0163 0.2314 0.2314
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Schistosoma mansoni notch 0.0148 0.2088 0.2088
Onchocerca volvulus Peroxidase homolog 0.0662 1 1
Schistosoma mansoni opsin-like receptor 0.0013 0.001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0163 0.0163
Loa Loa (eye worm) neuropeptide F receptor 0.0013 0.001 0.001
Schistosoma mansoni smad1 5 8 and 0.0035 0.0348 0.0348
Echinococcus multilocularis neuropeptide receptor A26 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Onchocerca volvulus Putative cubilin 0.0148 0.2088 0.2088
Echinococcus granulosus somatostatin receptor 0.0013 0.001 0.001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.071 0.6876
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0163 0.0163
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.005 0.005
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.071 0.2637
Brugia malayi EGF-like domain containing protein 0.0148 0.2088 0.2088
Schistosoma mansoni alpha-1 adrenergic receptor 0.0013 0.001 0.001
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0013 0.001 0.001
Echinococcus multilocularis neuropeptide receptor 0.0013 0.001 0.001
Brugia malayi MH2 domain containing protein 0.0515 0.7729 0.7729
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0013 0.001 0.001
Brugia malayi MH1 domain containing protein 0.0035 0.0348 0.0348
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0013 0.001 0.001
Brugia malayi Serotonin receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Schistosoma mansoni neuropeptide receptor 0.0013 0.001 0.001
Onchocerca volvulus Peroxidase homolog 0.0662 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.001 0.001
Echinococcus multilocularis G-protein coupled receptor, putative 0.0013 0.001 0.001
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0013 0.0003 0.0003
Onchocerca volvulus 0.0662 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Echinococcus granulosus 7TM GPCR rhodopsin 0.0013 0.001 0.001
Onchocerca volvulus 0.0013 0.001 0.001
Mycobacterium leprae Probable lipase LipE 0.0078 0.1013 0.5247
Echinococcus multilocularis notch 0.0148 0.2088 0.2088
Echinococcus granulosus GPCR family 2 0.0121 0.1675 0.1675
Schistosoma mansoni hypothetical protein 0.0121 0.1675 0.1675
Brugia malayi Smad1 0.0035 0.0348 0.0348
Echinococcus granulosus tm gpcr rhodopsin 0.0013 0.001 0.001
Schistosoma mansoni cell polarity protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) beta-lactamase 0.0078 0.1013 0.1013
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Echinococcus multilocularis dro:myosuppressin receptor 0.0013 0.001 0.001
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0013 0.001 0.001
Brugia malayi Animal haem peroxidase family protein 0.0662 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0013 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.4155 1
Echinococcus granulosus notch 0.0148 0.2088 0.2088
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0013 0.001 0.001
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0013 0.001 0.001
Onchocerca volvulus 0.0013 0.001 0.001
Brugia malayi Dopamine receptor 0.0013 0.001 0.001
Echinococcus multilocularis geminin 0.0544 0.8184 0.8184
Brugia malayi notch-like transmembrane receptor 0.0148 0.2088 0.2088
Brugia malayi EGF-like domain containing protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus neuropeptide Y receptor 0.0013 0.001 0.001
Loa Loa (eye worm) blistered cuticle protein 3 0.0662 1 1
Brugia malayi Latrophilin receptor protein 2 0.0121 0.1675 0.1675
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) animal heme peroxidase 0.0662 1 1
Brugia malayi hypothetical protein 0.0013 0.001 0.001
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0569 0.5512
Schistosoma mansoni amine GPCR 0.0013 0.001 0.001
Schistosoma mansoni notch 0.0148 0.2088 0.2088
Schistosoma mansoni hypothetical protein 0.0121 0.1675 0.1675
Schistosoma mansoni amine GPCR 0.0013 0.001 0.001
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0187 0.2692 0.2692
Echinococcus multilocularis neurogenic locus notch protein 0.0148 0.2088 0.2088
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0187 0.2692 0.3586
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0013 0.001 0.001
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0013 0.001 0.001
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0163 0.0163
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0348 0.0348
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.001 0.001
Schistosoma mansoni Smad4 0.0035 0.0348 0.0348
Trypanosoma brucei quiescin sulfhydryl oxidase 0.0013 0.0003 0.0029
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.015 0.015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0013 0.001 0.001
Trypanosoma cruzi quiescin sulfhydryl oxidase, putative 0.0013 0.0003 0.0029
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.008 0.1032 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0163 0.0163
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0013 0.001 0.001
Brugia malayi AKH receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Brugia malayi Intermediate filament tail domain containing protein 0.0061 0.074 0.074
Echinococcus granulosus protein jagged 1 0.0148 0.2088 0.2088
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.001 0.001
Brugia malayi GnHR receptor homolog 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0163 0.0163
Schistosoma mansoni neuropeptide F-like receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) G-protein coupled receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.001 0.001
Schistosoma mansoni ap endonuclease 0.0059 0.071 0.071
Brugia malayi Tachykinin-like peptides receptor 99D 0.0013 0.001 0.001
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.005 0.005
Echinococcus granulosus peroxidasin 0.0662 1 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Onchocerca volvulus 0.0078 0.1013 0.1013
Brugia malayi quiescin Q6 0.0013 0.0003 0.0003
Schistosoma mansoni lamin 0.0061 0.074 0.074
Loa Loa (eye worm) hypothetical protein 0.0096 0.1278 0.1278
Echinococcus multilocularis neuropeptides capa receptor 0.0013 0.001 0.001
Loa Loa (eye worm) intermediate filament protein 0.0061 0.074 0.074
Onchocerca volvulus 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Toxoplasma gondii Erv1 / Alr family protein 0.008 0.1032 0.3835
Onchocerca volvulus 0.0013 0.001 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.071 0.1709
Brugia malayi Cadherin domain containing protein 0.0148 0.2088 0.2088
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.071 0.1709
Plasmodium vivax hypothetical protein, conserved 0.0078 0.1013 0.9817
Echinococcus multilocularis protein jagged 1 0.0148 0.2088 0.2088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.071 0.6876
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.001 0.001
Schistosoma mansoni hypothetical protein 0.0096 0.1278 0.1278
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0383 0.5709 0.5709
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1013 0.2439
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.0662 1 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.1675 0.1675
Mycobacterium tuberculosis Conserved protein 0.0078 0.1013 0.135
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0163 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0163 0.0163
Schistosoma mansoni myosin xvIII 0.0013 0.001 0.001
Onchocerca volvulus 0.0078 0.1013 0.1013
Echinococcus multilocularis neurogenic locus notch protein 0.0148 0.2088 0.2088
Schistosoma mansoni smad1 5 8 and 0.0035 0.0348 0.0348
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0013 0.0003 0.0029
Onchocerca volvulus 0.0148 0.2088 0.2088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.1322 0.1322
Loa Loa (eye worm) hypothetical protein 0.0023 0.0163 0.0163
Schistosoma mansoni hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0163 0.0163
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.001 0.001
Echinococcus multilocularis serotonin receptor 0.0013 0.001 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0163 0.0163
Brugia malayi EGF-like domain containing protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) animal heme peroxidase 0.0662 1 1
Echinococcus multilocularis neuropeptide Y receptor 0.0013 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0078 0.1013 0.1013
Loa Loa (eye worm) transcription factor SMAD2 0.0515 0.7729 0.7729
Brugia malayi MH1 domain containing protein 0.0035 0.0348 0.0348
Onchocerca volvulus 0.0013 0.001 0.001
Echinococcus multilocularis neurogenic locus protein delta 0.0148 0.2088 0.2088
Brugia malayi hypothetical protein 0.0049 0.0569 0.0569
Echinococcus granulosus rhodopsin orphan GPCR 0.0013 0.001 0.001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0163 0.0163
Onchocerca volvulus 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0148 0.2088 0.2088
Loa Loa (eye worm) hypothetical protein 0.0013 0.001 0.001
Brugia malayi Dopamine receptor protein 1 0.0013 0.001 0.001
Schistosoma mansoni notch 0.0148 0.2088 0.2088
Schistosoma mansoni notch 0.0148 0.2088 0.2088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0013 0.001 0.001
Echinococcus granulosus lamin 0.0061 0.074 0.074
Brugia malayi beta-lactamase family protein 0.0078 0.1013 0.1013
Schistosoma mansoni septate junction protein 0.0148 0.2088 0.2088
Echinococcus granulosus neuropeptides capa receptor 0.0013 0.001 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.1013 0.1013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0282 0.4155 1
Brugia malayi Animal haem peroxidase family protein 0.0662 1 1
Brugia malayi neuropeptide F receptor 0.0013 0.001 0.001
Schistosoma mansoni Smad4 0.0016 0.005 0.005
Schistosoma mansoni peroxidasin 0.0662 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1013 0.1013
Onchocerca volvulus Neurogenic locus notch homolog 0.0148 0.2088 0.2088
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0163 0.0163
Echinococcus multilocularis rhodopsin orphan GPCR 0.0013 0.001 0.001
Schistosoma mansoni ap endonuclease 0.0059 0.071 0.071
Brugia malayi hypothetical protein 0.0013 0.001 0.001

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 193.5 uM Inhibition of mouse recombinant iNOS ChEMBL. 20958055
Ki (binding) = 18060 uM Inhibition of rat recombinant nNOS ChEMBL. 20958055
Ki (binding) = 18780 uM Inhibition of bovine recombinant eNOS ChEMBL. 20958055

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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