Detailed information for compound 1212284

Basic information

Technical information
  • TDR Targets ID: 1212284
  • Name: (Z)-2-cyano-3-(5-methylfuran-2-yl)-N-(1-pheny lethyl)prop-2-enamide
  • MW: 280.321 | Formula: C17H16N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.95 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C/c1ccc(o1)C)/C(=O)NC(c1ccccc1)C
  • InChi: 1S/C17H16N2O2/c1-12-8-9-16(21-12)10-15(11-18)17(20)19-13(2)14-6-4-3-5-7-14/h3-10,13H,1-2H3,(H,19,20)/b15-10-
  • InChiKey: XOMBGKSEBIATEF-GDNBJRDFSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (Z)-2-cyano-3-(5-methyl-2-furyl)-N-(1-phenylethyl)prop-2-enamide
  • (Z)-2-cyano-3-(5-methyl-2-furyl)-N-(1-phenylethyl)acrylamide
  • IVK/9122532
  • 2-cyano-3-(5-methyl-2-furyl)-N-(1-phenylethyl)acrylamide
  • MLS000703887
  • SMR000227657
  • AK-968/40606138

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0066 0.0183 0.4205
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0035
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.002 0.0032 0.039
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0138 0.0414 0.0414
Trichomonas vaginalis mercuric reductase, putative 0.002 0.0032 0.1761
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.016 0.016
Schistosoma mansoni polycystin 1-related 0.0023 0.0042 0.0042
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0067 0.0184 0.4045
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0929
Echinococcus multilocularis mitogen activated protein kinase 3 0.0067 0.0184 0.0184
Brugia malayi hypothetical protein 0.0029 0.0062 0.0054
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0035 0.0027
Schistosoma mansoni hypothetical protein 0.0946 0.3025 0.3025
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.0011
Loa Loa (eye worm) acetyltransferase 0.0168 0.0511 0.0504
Echinococcus granulosus mitogen activated protein kinase 0.0067 0.0184 0.0184
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.002 0.0032 0.0127
Loa Loa (eye worm) hypothetical protein 0.0059 0.016 0.0152
Brugia malayi hypothetical protein 0.0019 0.0029 0.0021
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0067 0.0184 0.8373
Echinococcus multilocularis muscleblind protein 1 0.018 0.0551 0.0551
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0062 0.1864
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0017 0.0929
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0008 0.0008
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0214 0.0214
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0141 0.0425 0.0417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0032 0.0262
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0035 0.0035
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0008 0.0008
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0128 0.2603
Giardia lamblia Kinase, CMGC MAPK 0.0067 0.0184 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0929
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0008 0.0008
Brugia malayi hypothetical protein 0.0023 0.0042 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0008 0.0008
Schistosoma mansoni coup transcription factor 0.0012 0.0008 0.0008
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0214 1
Schistosoma mansoni cpg binding protein 0.0066 0.0183 0.0183
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0032 0.0262
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0032 1
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0027 0.002
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.3105 1 1
Echinococcus granulosus muscleblind protein 0.018 0.0551 0.0551
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0153 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0027 0.002
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0042 0.0042
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0137 0.0137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0147 0.0147
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0062 0.1864
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0389 0.8923
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0064 0.0176 0.0176
Echinococcus granulosus dnaJ subfamily B 0.0946 0.3025 0.3025
Toxoplasma gondii aldehyde dehydrogenase 0.0138 0.0414 1
Schistosoma mansoni hypothetical protein 0.032 0.1003 0.1003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0032 0.0262
Loa Loa (eye worm) CXXC zinc finger family protein 0.0066 0.0183 0.0175
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0008 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0008 0.0008
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.016 0.016
Trypanosoma brucei protein kinase, putative 0.0067 0.0184 0.8373
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0067 0.0184 0.8373
Toxoplasma gondii thioredoxin reductase 0.0057 0.0153 0.3246
Toxoplasma gondii histone lysine methyltransferase SET1 0.013 0.0388 0.9339
Brugia malayi Thioredoxin reductase 0.0057 0.0153 0.0145
Schistosoma mansoni hypothetical protein 0.0023 0.0042 0.0042
Loa Loa (eye worm) MBCTL1 0.0059 0.016 0.0152
Schistosoma mansoni ap endonuclease 0.0018 0.0027 0.0027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0008 0.0008
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0032 0.0032
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0214 0.0206
Echinococcus multilocularis microtubule associated protein 2 0.0795 0.2537 0.2537
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0111 0.0111
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0022 0.0022
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0184 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0027 0.0027
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0209 0.0643 0.0643
Brugia malayi MAP kinase sur-1 0.0067 0.0184 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0929
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0067 0.0184 0.0176
Schistosoma mansoni ap endonuclease 0.0018 0.0027 0.0027
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0008 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.002 0.0032 0.0262
Onchocerca volvulus Huntingtin homolog 0.0141 0.0425 1
Schistosoma mansoni rab6-interacting 0.0023 0.0042 0.0042
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0436 1
Schistosoma mansoni hypothetical protein 0.0383 0.1207 0.1207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0017 0.0929
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0137 0.0137
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0042 0.0042
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0032 0.0262
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0184 0.8373
Schistosoma mansoni cpg binding protein 0.007 0.0195 0.0195
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0147 0.0147
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0032 0.0262
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0076 0.0214 0.4831
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0137 0.0137
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0027 0.1494
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0929
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0032 0.0262
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0147 0.0147
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0027 0.1494
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0062 0.2775
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.002 0.0032 0.0782
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0008 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0008 0.0008
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0128 0.6968
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0017 0.0929
Echinococcus granulosus mitogen activated protein kinase 3 0.0067 0.0184 0.0184
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0168 0.0511 0.0511
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0042 0.0042
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0064 0.0176 0.0176
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0032 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0389 0.8923
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0067 0.0184 0.4045
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0929
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0062 0.2775
Onchocerca volvulus Huntingtin homolog 0.0141 0.0425 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0147 0.0147
Brugia malayi Doublecortin family protein 0.0023 0.0042 0.0035
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0128 0.2603
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0141 0.0424 0.0424
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0008 0.0008
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0137 0.0137
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0389 0.8923
Treponema pallidum NADH oxidase 0.002 0.0032 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0008 0.0008
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0111 0.0111
Plasmodium vivax glutathione reductase, putative 0.0057 0.0153 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0067 0.0184 0.8373
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0022 0.0022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0214 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0389 0.8923
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.002 0.0032 0.0742
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0032 0.0262
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0032 0.0127
Loa Loa (eye worm) hypothetical protein 0.018 0.0551 0.0544
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.002 0.0032 0.0782
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0008 0.0008
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0011 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0929
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0042 0.0035
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.002 0.0032 0.039
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0209 0.0643 0.0643
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.002 0.0032 0.0262
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0147 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0929
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0138 0.0414 1
Schistosoma mansoni serine/threonine protein kinase 0.0067 0.0184 0.0184
Echinococcus granulosus cpg binding protein 0.007 0.0195 0.0195
Loa Loa (eye worm) glutathione reductase 0.0057 0.0153 0.0145
Giardia lamblia NADH oxidase lateral transfer candidate 0.002 0.0032 0.0313
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0027 0.063
Leishmania major dihydrolipoamide dehydrogenase, putative 0.002 0.0032 0.0127
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0008 0.0008
Trichomonas vaginalis glutathione reductase, putative 0.002 0.0032 0.1761
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0436 1
Schistosoma mansoni serine/threonine protein kinase 0.3105 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0027 0.0027
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.002 0.0032 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0929
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0017 0.0929
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0042 0.0042
Leishmania major acetoin dehydrogenase e3 component-like protein 0.002 0.0032 0.0127
Schistosoma mansoni loxhd1 0.0023 0.0042 0.0042
Toxoplasma gondii NADPH-glutathione reductase 0.002 0.0032 0.0127
Mycobacterium ulcerans flavoprotein disulfide reductase 0.002 0.0032 0.0782
Onchocerca volvulus 0.0023 0.0042 0.0829
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0214 0.0206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0137 0.0129
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0214 0.0214
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.002 0.0032 0.039
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0008 0.0008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0008 0.0008
Brugia malayi hypothetical protein 0.0141 0.0425 0.0417
Brugia malayi mbt repeat family protein 0.0052 0.0137 0.0129
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0147 0.0147
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0032 0.0032
Brugia malayi hypothetical protein 0.0023 0.0042 0.0035
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0027 0.8487
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0008 0.0008
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0153 0.3506
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.018 0.0551 0.0544
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0029 0.0062 0.0901
Trypanosoma cruzi trypanothione reductase, putative 0.002 0.0032 0.0262
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0137 0.0137
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0137 0.3091
Loa Loa (eye worm) hypothetical protein 0.0029 0.0062 0.0054
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0214 1
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0137 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0017 0.0929
Echinococcus granulosus RUN 0.0023 0.0042 0.0042
Echinococcus granulosus microtubule associated protein 2 0.0795 0.2537 0.2537
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0436 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0017 0.0929
Schistosoma mansoni rab6-interacting 0.0023 0.0042 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0008 0.0008
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.3105 1 1
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0042 0.1191
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0147 0.0139
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0015 0.0015 0.0008
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0027 0.8487
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0008 0.0008
Echinococcus granulosus geminin 0.0383 0.1207 0.1207
Schistosoma mansoni lipoxygenase 0.0023 0.0042 0.0042
Mycobacterium ulcerans aldehyde dehydrogenase 0.0138 0.0414 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0032 0.0032
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0008 0.0008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0027 0.0664
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0137 0.0129
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0389 0.8923
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0035 0.0035
Mycobacterium tuberculosis Probable reductase 0.013 0.0389 0.8923
Plasmodium falciparum glutathione reductase 0.0057 0.0153 1
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0062 0.0901
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0034 0.0026
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0042 0.0042
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0128 0.6968
Brugia malayi Muscleblind-like protein 0.018 0.0551 0.0544
Plasmodium falciparum thioredoxin reductase 0.0057 0.0153 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0008 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0138 0.0414 0.0414
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0153 0.0153
Mycobacterium ulcerans aldehyde dehydrogenase 0.0138 0.0414 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0032 0.0025
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0115 0.696
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0008 0.0008
Schistosoma mansoni microtubule-associated protein tau 0.0795 0.2537 0.2537
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.002 0.0032 0.039
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0011 0.0011
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0153 0.0153
Schistosoma mansoni aldehyde dehydrogenase 0.0138 0.0414 0.0414
Echinococcus granulosus MAP kinase activated protein kinase 2 0.3105 1 1
Schistosoma mansoni cpg binding protein 0.007 0.0195 0.0195
Trichomonas vaginalis helicase, putative 0.0015 0.0017 0.0929
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0389 0.8923
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0017 0.0929
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0184 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0032 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0147 0.0147
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0147 0.0147
Brugia malayi CXXC zinc finger family protein 0.0066 0.0183 0.0175
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0015 0.0015 0.0008
Schistosoma mansoni lipoxygenase 0.0064 0.0176 0.0176
Echinococcus multilocularis mitogen activated protein kinase 0.0067 0.0184 0.0184
Echinococcus multilocularis dnaJ subfamily B 0.0946 0.3025 0.3025
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.016 0.016
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.016 0.016
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0008 0.0008
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0042 0.1191
Loa Loa (eye worm) hypothetical protein 0.0141 0.0425 0.0417
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0115 0.5585
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0214 1
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0153 0.6719
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0138 0.0414 0.949
Plasmodium falciparum thioredoxin reductase 0.002 0.0032 0.039
Plasmodium falciparum glutathione reductase 0.002 0.0032 0.039
Brugia malayi mbt repeat family protein 0.0052 0.0137 0.0129
Loa Loa (eye worm) hypothetical protein 0.0023 0.0042 0.0035
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0128 0.0128
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0137 0.0137
Echinococcus granulosus histone acetyltransferase KAT2B 0.0163 0.0496 0.0496
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.002 0.0032 0.0262
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.016 0.0152
Echinococcus multilocularis muscleblind protein 0.018 0.0551 0.0551
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.002 0.0032 0.0262
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0184 1
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0153 0.0145
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0062 0.2775
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0022 0.0022
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0062 0.1864
Brugia malayi glutathione reductase 0.0057 0.0153 0.0145
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0017 0.0929
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0067 0.0184 0.4045
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0067 0.0184 0.8373
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0008 0.0008
Echinococcus multilocularis RUN 0.0023 0.0042 0.0042
Trypanosoma brucei trypanothione reductase 0.0057 0.0153 0.6719
Mycobacterium ulcerans aldehyde dehydrogenase 0.0138 0.0414 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0138 0.0414 0.0414
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.016 0.016
Schistosoma mansoni hypothetical protein 0.0383 0.1207 0.1207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0017 0.0929
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0008 0.0008
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0128 0.802
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0214 0.0214
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.002 0.0032 0.0262
Trichomonas vaginalis CMGC family protein kinase 0.0067 0.0184 1
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0008 0.0008
Onchocerca volvulus 0.0052 0.0137 0.3091
Leishmania major trypanothione reductase 0.0057 0.0153 0.3246
Onchocerca volvulus 0.0023 0.0042 0.0829
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0168 0.0511 0.0511
Echinococcus multilocularis geminin 0.0383 0.1207 0.1207
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0436 1
Echinococcus multilocularis cpg binding protein 0.007 0.0195 0.0195
Brugia malayi acetyltransferase, GNAT family protein 0.0168 0.0511 0.0504
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0022 0.0022
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0115 0.4676

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.037 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 7.9433 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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