Detailed information for compound 1223671

Basic information

Technical information
  • TDR Targets ID: 1223671
  • Name: 1-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4- yl]methyl]-N-(oxolan-2-ylmethyl)piperidine-4- carboxamide
  • MW: 417.929 | Formula: C22H28ClN3O3
  • H donors: 1 H acceptors: 2 LogP: 3.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)Cc1nc(oc1C)c1ccc(cc1)Cl)NCC1CCCO1
  • InChi: 1S/C22H28ClN3O3/c1-15-20(25-22(29-15)17-4-6-18(23)7-5-17)14-26-10-8-16(9-11-26)21(27)24-13-19-3-2-12-28-19/h4-7,16,19H,2-3,8-14H2,1H3,(H,24,27)
  • InChiKey: BJACUCGKWLTKHA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[[2-(4-chlorophenyl)-5-methyl-oxazol-4-yl]methyl]-N-(tetrahydrofuran-2-ylmethyl)piperidine-4-carboxamide
  • 1-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methyl]-N-(2-tetrahydrofuranylmethyl)-4-piperidinecarboxamide
  • 1-[[2-(4-chlorophenyl)-5-methyl-oxazol-4-yl]methyl]-N-(tetrahydrofurfuryl)isonipecotamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0663 0.2858
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0122 0.0239
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0457 0.0917
Loa Loa (eye worm) hypothetical protein 0.0043 0.0956 0.1925
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.221 0.3875
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0232 0.0355
Brugia malayi Cathepsin L-like cysteine proteinase 0.004 0.0864 0.1738
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0285 0.0392
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0057 0.1295 0.1292
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0043 0.0081
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0457 0.191
Trypanosoma cruzi major cysteine proteinase, putative 0.0014 0.0232 0.0463
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0309 0.0427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0663 0.1332
Loa Loa (eye worm) fibroinase 0.0057 0.1295 0.2609
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0613 0.061
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0898 0.1808
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.1295 0.5774
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0956 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0063 0.1434 0.1434
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0122 0.0239
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.221 0.221
Echinococcus granulosus cathepsin L 0.0014 0.0232 0.0229
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0956 0.1381
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0122 0.0139
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0329 0.3129
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0285 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Entamoeba histolytica hypothetical protein 0.0014 0.0232 0.087
Giardia lamblia Cathepsin B precursor 0.0063 0.1434 0.6078
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0122 0.0239
Brugia malayi CXXC zinc finger family protein 0.0028 0.0582 0.117
Schistosoma mansoni nuclear hormone receptor 0.001 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0239
Mycobacterium tuberculosis Conserved protein 0.0043 0.0956 0.1381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.221 0.3863
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0232 0.0462
Mycobacterium leprae Probable lipase LipE 0.0043 0.0956 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0956 0.1925
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0122 0.0118
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0014 0.0232 0.1508
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0057 0.1295 0.2609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0122 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0014 0.0232 0.0355
Loa Loa (eye worm) beta-lactamase 0.0043 0.0956 0.1925
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0014 0.0232 0.1508
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0122 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0613 0.0613
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0043 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0232 0.0462
Schistosoma mansoni cpg binding protein 0.0028 0.0582 0.0582
Onchocerca volvulus 0.0057 0.1295 0.2231
Leishmania major cathepsin L-like protease 0.0057 0.1295 0.5774
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0014 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0014 0.0232 0.0462
Toxoplasma gondii ABC1 family protein 0.0043 0.0956 0.6563
Echinococcus multilocularis cysteine protease 0.0057 0.1295 0.1292
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0014 0.0232 0.1508
Brugia malayi steroid hormone receptor 0.001 0.0122 0.0239
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0122 0.0239
Giardia lamblia Cathepsin B precursor 0.0063 0.1434 0.6078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0232 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Mycobacterium tuberculosis Conserved protein 0.0043 0.0956 0.1381
Onchocerca volvulus 0.0023 0.0457 0.0738
Giardia lamblia Cathepsin B precursor 0.0063 0.1434 0.6078
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0239
Onchocerca volvulus 0.004 0.0864 0.1463
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.1295 0.2246
Echinococcus granulosus cathepsin L cysteine proteinase 0.0057 0.1295 0.1292
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.017 0.412 0.412
Plasmodium vivax unspecified product 0.0032 0.0663 0.495
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0457 0.4535
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0347 0.0343
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Echinococcus multilocularis cathepsin L cysteine protease 0.0057 0.1295 0.1292
Brugia malayi Cathepsin L-like precursor 0.0057 0.1295 0.2609
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0122 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Plasmodium falciparum serine repeat antigen 2 0.0014 0.0232 0.1508
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0014 0.0232 0.087
Schistosoma mansoni kinase 0.0048 0.106 0.106
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0122 0.0239
Brugia malayi cathepsin L-like precursor 0.004 0.0864 0.1738
Leishmania major cathepsin L-like protease 0.0057 0.1295 0.5774
Loa Loa (eye worm) ctsf protein 0.0057 0.1295 0.2609
Plasmodium vivax serine-repeat antigen (SERA) 0.0014 0.0232 0.1508
Echinococcus multilocularis cathepsin b 0.017 0.412 0.4118
Schistosoma mansoni thyroid hormone receptor 0.001 0.0122 0.0122
Trypanosoma cruzi major cysteine proteinase, putative 0.0014 0.0232 0.0463
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0122 0.0122
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0232 0.0232
Echinococcus granulosus cathepsin b 0.017 0.412 0.4118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0457 0.0917
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.221 0.5316
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.1295 0.2246
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.0041 0.0898 0.1808
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0014 0.0232 0.1508
Trypanosoma brucei cysteine peptidase C (CPC) 0.0063 0.1434 0.6419
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0057 0.1295 0.2246
Plasmodium vivax vivapain-1 0.0032 0.0663 0.495
Brugia malayi beta-lactamase 0.0043 0.0956 0.1925
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1374 0.2768
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.1295 0.2246
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0122 0.0239
Echinococcus multilocularis muscleblind protein 1 0.0148 0.3564 0.3562
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Entamoeba histolytica cysteine proteinase 1, putative 0.0032 0.0663 0.2858
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0122 0.0239
Onchocerca volvulus 0.0043 0.0956 0.1628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0122 0.0239
Onchocerca volvulus 0.0057 0.1295 0.2231
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1374 0.2768
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0613 0.0613
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.1295 0.2246
Leishmania major cysteine peptidase A (CPA) 0.0057 0.1295 0.5774
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0457 0.0917
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0285 0.0392
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0239
Brugia malayi ecdysteroid receptor 0.001 0.0122 0.0239
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.017 0.412 0.412
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0122 0.0239
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1374 0.2768
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0043 0.0081
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0956 0.1381
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0014 0.0232 0.0355
Echinococcus granulosus cysteine protease 0.0032 0.0663 0.066
Schistosoma mansoni hypothetical protein 0.0041 0.0898 0.0898
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.017 0.412 0.412
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0457 0.0646
Onchocerca volvulus 0.0057 0.1295 0.2231
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0122 0.0239
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0043 0.0019
Mycobacterium ulcerans beta-lactamase 0.0043 0.0956 1
Loa Loa (eye worm) cysteine protease 0.0057 0.1295 0.2609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0329 0.0658
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Echinococcus granulosus cathepsin l1 0.004 0.0864 0.0861
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0043 0.0035
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0043 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0232 0.0355
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0057 0.1295 0.2246
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0014 0.0232 0.087
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0063 0.1434 0.3412
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0043 0.0035
Schistosoma mansoni hypothetical protein 0.0019 0.0347 0.0347
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Brugia malayi hypothetical protein 0.0147 0.3549 0.7165
Onchocerca volvulus 0.0043 0.0956 0.1628
Entamoeba histolytica cysteine protease, putative 0.0014 0.0232 0.087
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Brugia malayi fibroinase precursor 0.0014 0.0232 0.0462
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0014 0.0232 0.1508
Giardia lamblia Kinase, PLK 0.0094 0.221 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1029 0.1774
Leishmania major cathepsin L-like protease 0.0057 0.1295 0.5774
Brugia malayi beta-lactamase family protein 0.0043 0.0956 0.1925
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0014 0.0232 0.1508
Toxoplasma gondii cathepsin B 0.0063 0.1434 1
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0956 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0864 0.1479
Echinococcus multilocularis cathepsin L cysteine protease 0.0057 0.1295 0.1292
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0014 0.0232 0.0232
Brugia malayi nuclear receptor NHR-88 0.001 0.0122 0.0239
Loa Loa (eye worm) hypothetical protein 0.0017 0.0302 0.0603
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0122 0.0118
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0329 0.0658
Plasmodium falciparum serine repeat antigen 5 0.0014 0.0232 0.1508
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0663 0.2858
Brugia malayi Cathepsin L-like precursor 0.0057 0.1295 0.2609
Trypanosoma brucei polo-like protein kinase 0.0094 0.221 1
Schistosoma mansoni cathepsin C 0.0014 0.0232 0.0232
Echinococcus granulosus cathepsin l cysteine peptidase 0.0057 0.1295 0.1292
Brugia malayi cathepsin F-like cysteine proteinase 0.0014 0.0232 0.0462
Entamoeba histolytica cysteine protease, putative 0.0014 0.0232 0.087
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1406 0.1406
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0457 0.4535
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.1738
Echinococcus multilocularis cysteine protease 0.0057 0.1295 0.1292
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.017 0.412 0.412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0232 0.0355
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0956 0.1925
Echinococcus granulosus muscleblind protein 0.0148 0.3564 0.3562
Onchocerca volvulus 0.0232 0.5652 1
Schistosoma mansoni coup transcription factor 0.001 0.0122 0.0122
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0043 0.0043
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0347 0.0343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0663 0.152
Brugia malayi cathepsin L precursor 0.0014 0.0232 0.0462
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0347 0.0343
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0014 0.0232 0.1508
Loa Loa (eye worm) hypothetical protein 0.0148 0.3564 0.7194
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.1295 0.307
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0956 1
Brugia malayi Pre-SET motif family protein 0.003 0.0613 0.1232
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.221 0.3875
Loa Loa (eye worm) hypothetical protein 0.006 0.1374 0.2768
Entamoeba histolytica cysteine protease, putative 0.0014 0.0232 0.087
Brugia malayi beta-lactamase family protein 0.0043 0.0956 0.1925
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0122 0.0239
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0347 0.0693
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0347 0.0693
Entamoeba histolytica cysteine protease, putative 0.0057 0.1295 0.5774
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0663 0.2858
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0014 0.0232 0.0355
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0122 0.0118
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0457 0.4535
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.221 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0043 0.0081
Echinococcus multilocularis cpg binding protein 0.003 0.0623 0.062
Trichomonas vaginalis esterase, putative 0.0043 0.0956 0.1644
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0122 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1029 0.1774
Plasmodium falciparum serine repeat antigen 8 0.0014 0.0232 0.1508
Onchocerca volvulus 0.0057 0.1295 0.2231
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0582 0.117
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0956 0.1644
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0118 0.0115
Mycobacterium ulcerans lipase LipD 0.0043 0.0956 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0014 0.0232 0.1508
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0043 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0232 0.0355
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0122 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0014 0.0232 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.017 0.412 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0329 0.0701
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0063 0.1434 0.2495
Onchocerca volvulus 0.0147 0.3549 0.625
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0302 0.0635
Echinococcus multilocularis cathepsin L 0.0014 0.0232 0.0229
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0014 0.0232 0.0232
Entamoeba histolytica cysteine proteinase 2 0.0032 0.0663 0.2858
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0329 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0057 0.1295 0.307
Mycobacterium ulcerans hypothetical protein 0.0023 0.0457 0.4535
Loa Loa (eye worm) hypothetical protein 0.0014 0.0232 0.0462
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0014 0.0232 0.0462
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0302 0.0603
Brugia malayi Cathepsin L-like precursor 0.0057 0.1295 0.2609
Plasmodium falciparum serine repeat antigen 7 0.0014 0.0232 0.1508
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0956 0.0953
Plasmodium falciparum serine repeat antigen 9 0.0014 0.0232 0.1508
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0043 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0122 0.0239
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0347 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0122 0.0239
Plasmodium vivax serine-repeat antigen (SERA) 0.0014 0.0232 0.1508
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0329 0.0528
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0239
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0017 0.0302 0.0603
Trichomonas vaginalis set domain proteins, putative 0.0232 0.5652 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.1295 0.2246
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0232 0.0462
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.221 0.4459
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Echinococcus granulosus GPCR family 2 0.0019 0.0347 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0457 0.191
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0014 0.0232 0.1508
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0956 0.4213
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0232 0.0462
Toxoplasma gondii cathepsin CPC1 0.0014 0.0232 0.1356
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0057 0.1295 0.1292
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0956 0.1381
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0122 0.0239
Loa Loa (eye worm) hypothetical protein 0.003 0.0613 0.1232
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0075 0.0071
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0457 0.4535
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0956 0.1644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0122 0.0239
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0122 0.0118
Toxoplasma gondii cathepsin CPL 0.0057 0.1295 0.8995
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0122 0.0122
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0457 0.4535
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0329 0.0701
Schistosoma mansoni cpg binding protein 0.003 0.0623 0.0623
Echinococcus granulosus cpg binding protein 0.003 0.0623 0.062
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0075 0.0071
Brugia malayi Cathepsin L-like precursor 0.004 0.0864 0.1738
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0329 0.1318
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0043 0.0081
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0043 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0232 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0122 0.0239
Brugia malayi Papain family cysteine protease containing protein 0.0057 0.1295 0.2609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.221 0.4459
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.1295 0.2246
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0057 0.1295 0.2609
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.221 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0956 0.1644
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0032 0.0663 0.152
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0043 0.0035
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0613 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.004 0.0864 0.1479
Entamoeba histolytica cysteine proteinase, putative 0.004 0.0864 0.3786
Loa Loa (eye worm) hypothetical protein 0.0043 0.0956 0.1925
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.1295 0.1295
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0239
Schistosoma mansoni cathepsin B (C01 family) 0.0014 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.1295 0.2246
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.221 0.3875
Loa Loa (eye worm) hypothetical protein 0.017 0.412 0.8317
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0122 0.0239
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.1738
Brugia malayi cathepsin Z-like cysteine proteinase 0.0014 0.0232 0.0462
Brugia malayi Cathepsin L-like precursor 0.0017 0.0302 0.0603
Plasmodium vivax vivapain-3 0.0032 0.0663 0.495
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0232 0.0355
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0956 0.7296
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0043 0.004
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0663 0.2858
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0457 0.191
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0329 0.5
Schistosoma mansoni hypothetical protein 0.0406 1 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0122 0.0239
Echinococcus multilocularis dnaJ subfamily B 0.0406 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0864 0.1738
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0663 0.152
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0057 0.1295 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0309 0.5
Leishmania major cathepsin L-like protease 0.0057 0.1295 0.5774
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Brugia malayi cathepsin L-like cysteine proteinase 0.0014 0.0232 0.0462
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0239
Leishmania major cathepsin L-like protease 0.0057 0.1295 0.5774
Loa Loa (eye worm) hypothetical protein 0.0148 0.3564 0.7194
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0003 0.0003
Onchocerca volvulus 0.0057 0.1295 0.2231
Schistosoma mansoni cathepsin F (C01 family) 0.004 0.0864 0.0864
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0329 0.0528
Echinococcus granulosus FTZ F1 alpha 0.001 0.0122 0.0118
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.221 0.5316
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0956 0.224
Onchocerca volvulus 0.0028 0.0582 0.0961
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0014 0.0232 0.0232
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0122 0.0239
Echinococcus multilocularis muscleblind protein 0.0148 0.3564 0.3562
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0956 0.0956
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0014 0.0232 0.0462
Entamoeba histolytica cysteine proteinase, putative 0.0057 0.1295 0.5774
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0956 0.1644
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0663 0.0663
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0457 0.191
Loa Loa (eye worm) histone methyltransferase 0.001 0.0118 0.0231
Brugia malayi Cathepsin L-like precursor 0.004 0.0864 0.1738
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.0017 0.0302 0.0603
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0613 0.4098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0457 0.0646
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.1295 0.307
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0122 0.0139
Onchocerca volvulus 0.001 0.0122 0.0139
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0057 0.1295 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0075 0.0071
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0613 0.0613
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0239
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.221 0.3875
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0122 0.0118
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0043 0.004
Echinococcus multilocularis cathepsin L 0.0032 0.0663 0.066
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0618
Loa Loa (eye worm) hypothetical protein 0.0057 0.1295 0.2609
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0014 0.0232 0.1508
Onchocerca volvulus 0.0057 0.1295 0.2231
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0329 0.0456
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0457 0.191
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.1295 0.307
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.4953 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0309 0.2912
Loa Loa (eye worm) hypothetical protein 0.0023 0.0457 0.0917
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0956 0.224
Brugia malayi Papain family cysteine protease containing protein 0.0014 0.0232 0.0462
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0122 0.0122
Brugia malayi cathepsin B-like cysteine proteinase 0.017 0.412 0.8317
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0309 0.2125
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0956 0.1381
Mycobacterium ulcerans hypothetical protein 0.0043 0.0956 1
Echinococcus granulosus cathepsin L cysteine protease 0.0032 0.0663 0.066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0956 0.1925
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0663 0.2858
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0618
Brugia malayi Cathepsin L-like precursor 0.0057 0.1295 0.2609
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0122 0.0118
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0663 0.2858
Trypanosoma cruzi cruzipain precursor, putative 0.0017 0.0302 0.0635
Loa Loa (eye worm) cathepsin B 0.0063 0.1434 0.2891
Loa Loa (eye worm) hypothetical protein 0.0014 0.0232 0.0462
Entamoeba histolytica cysteine protease, putative 0.0014 0.0232 0.087
Trypanosoma cruzi cysteine protease, putative 0.0032 0.0663 0.152
Brugia malayi cathepsin Z-like cysteine proteinase 0.0014 0.0232 0.0462
Toxoplasma gondii preprocathepsin c precursor, putative 0.0014 0.0232 0.1356
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0329 0.0326
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0043 0.0081
Loa Loa (eye worm) hypothetical protein 0.0007 0.0043 0.0081
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0014 0.0232 0.1508
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.221 0.3875
Onchocerca volvulus 0.0057 0.1295 0.2231
Schistosoma mansoni hypothetical protein 0.0019 0.0347 0.0347
Plasmodium vivax vivapain-2 0.0057 0.1295 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0014 0.0232 0.0462
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0309 0.2125
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0457 0.191
Brugia malayi Pre-SET motif family protein 0.0204 0.4953 1
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0122 0.0239
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0118 0.0115
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0457 0.4535
Loa Loa (eye worm) hypothetical protein 0.0017 0.0302 0.0603
Onchocerca volvulus Cathepsin L homolog 0.0014 0.0232 0.0336
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0571 0.0568
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0329 0.1318
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0043 0.0035
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0329 0.2283
Brugia malayi cathepsin F-like cysteine proteinase 0.0017 0.0302 0.0603
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0057 0.1295 0.2246
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0043 0.0035
Entamoeba histolytica cysteine protease, putative 0.0014 0.0232 0.087
Schistosoma mansoni ap endonuclease 0.0018 0.0329 0.0329
Loa Loa (eye worm) hypothetical protein 0.0023 0.0457 0.0917
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0232 0.0355
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0122 0.0122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0232 0.0355
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0122 0.0118
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0075 0.0075
Echinococcus multilocularis cathepsin b 0.017 0.412 0.4118
Loa Loa (eye worm) hypothetical protein 0.0019 0.0347 0.0693
Loa Loa (eye worm) hypothetical protein 0.0043 0.0956 0.1925
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0956 0.1644
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0956 0.0956
Loa Loa (eye worm) hypothetical protein 0.0007 0.0043 0.0081
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0115 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0122 0.0239
Trypanosoma cruzi cysteine proteinase, putative 0.0032 0.0663 0.152
Schistosoma mansoni hypothetical protein 0.0019 0.0347 0.0347
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0329 0.1318
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0043 0.0081
Echinococcus granulosus cathepsin L 0.0032 0.0663 0.066
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0956 0.0953
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0329 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0232 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0122 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0613 0.0613
Mycobacterium tuberculosis Conserved protein 0.0043 0.0956 0.1381
Onchocerca volvulus Cathepsin F homolog 0.0057 0.1295 0.2231
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0663 0.1332
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0232 0.0232
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.6803 1
Plasmodium vivax unspecified product 0.0014 0.0232 0.1508
Plasmodium falciparum serine repeat antigen 3 0.0014 0.0232 0.1508
Schistosoma mansoni cathepsin F (C01 family) 0.0057 0.1295 0.1295
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0457 0.0917
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0043 0.0035
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.221 0.2208
Loa Loa (eye worm) hypothetical protein 0.0147 0.3549 0.7165
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.1295 0.2246
Brugia malayi nuclear hormone receptor 0.001 0.0122 0.0239
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0956 0.1381
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0122 0.0118
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.221 0.3875
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0122 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0239
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0618
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0057 0.1295 0.2246
Plasmodium vivax SET domain protein, putative 0.003 0.0613 0.4556
Brugia malayi Cathepsin L-like precursor 0.0057 0.1295 0.2609
Plasmodium falciparum cysteine proteinase falcipain 3 0.0057 0.1295 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0122 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0014 0.0232 0.0355
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0457 0.4535
Leishmania major cathepsin L-like protease 0.0057 0.1295 0.5774
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0122 0.0139
Loa Loa (eye worm) hypothetical protein 0.0043 0.0956 0.1925
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0329 0.2283
Schistosoma mansoni thyroid hormone receptor 0.001 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0043 0.0956 0.1925
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0347 0.0693
Onchocerca volvulus Cathepsin L homolog 0.0057 0.1295 0.2231
Leishmania major hypothetical protein, conserved 0.0043 0.0956 0.4213
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0663 0.0663
Onchocerca volvulus 0.0043 0.0956 0.1628
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0014 0.0232 0.0355
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0956 0.1381
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0122 0.0239
Plasmodium falciparum serine repeat antigen 1 0.0014 0.0232 0.1508
Onchocerca volvulus 0.0014 0.0232 0.0336
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0122 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0014 0.0232 0.0355
Echinococcus multilocularis GPCR, family 2 0.0019 0.0347 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0014 0.0232 0.0355
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0014 0.0232 0.0232
Plasmodium falciparum cysteine proteinase falcipain 1 0.0032 0.0663 0.495
Leishmania major cathepsin L-like protease 0.0057 0.1295 0.5774
Brugia malayi Cathepsin L-like precursor 0.0057 0.1295 0.2609
Trypanosoma cruzi cysteine peptidase, putative 0.0057 0.1295 0.307
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.221 0.2208
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0043 0.0035
Schistosoma mansoni cpg binding protein 0.003 0.0623 0.0623
Leishmania major cathepsin L-like protease 0.0057 0.1295 0.5774
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0032 0.0663 0.0663
Echinococcus granulosus cathepsin b 0.017 0.412 0.4118
Echinococcus granulosus cathepsin l1 0.0057 0.1295 0.1292
Schistosoma mansoni cathepsin S (C01 family) 0.0014 0.0232 0.0232
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.004 0.0864 0.2013
Brugia malayi Muscleblind-like protein 0.0148 0.3564 0.7194
Schistosoma mansoni hypothetical protein 0.0019 0.0347 0.0347
Toxoplasma gondii exonuclease III APE 0.0018 0.0329 0.2054
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0122 0.0122
Plasmodium falciparum serine repeat antigen 4 0.0014 0.0232 0.1508
Onchocerca volvulus Cathepsin L homolog 0.0057 0.1295 0.2231
Plasmodium falciparum serine repeat antigen 6 0.0014 0.0232 0.1508
Plasmodium vivax vivapain-2 0.0057 0.1295 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0043 0.0081
Schistosoma mansoni cathepsin s 0.0017 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0618
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0285 0.0392
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0075 0.0071
Toxoplasma gondii cathepsin CPC2 0.0014 0.0232 0.1356
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0014 0.0232 0.0355
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.221 0.3875
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0122 0.0239
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0014 0.0232 0.0462
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0329 0.0326
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0122 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0043 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0309 0.0618
Schistosoma mansoni ap endonuclease 0.0018 0.0329 0.0329
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1245 0.8641
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0014 0.0232 0.0355
Loa Loa (eye worm) oxidoreductase 0.0007 0.0043 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0057 0.1295 0.5774
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0122 0.0118
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0457 0.4535
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0014 0.0232 0.1508
Onchocerca volvulus 0.003 0.0613 0.1016
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0063 0.1434 0.6419
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0663 0.1122
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0457 0.4535
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0613 0.061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0663 0.1122
Entamoeba histolytica cysteine protease, putative 0.0014 0.0232 0.087
Plasmodium vivax unspecified product 0.0017 0.0302 0.2068
Entamoeba histolytica cysteine protease, putative 0.0032 0.0663 0.2858
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0956 0.1381
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0014 0.0232 0.1508

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.