Detailed information for compound 1255671

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 386.443 | Formula: C24H22N2O3
  • H donors: 1 H acceptors: 4 LogP: 3.67 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cn1)C(=O)N1CCCC(C1)C(=O)c1ccc2c3c1cccc3CC2
  • InChi: 1S/C24H22N2O3/c27-21-11-9-17(13-25-21)24(29)26-12-2-4-18(14-26)23(28)20-10-8-16-7-6-15-3-1-5-19(20)22(15)16/h1,3,5,8-11,13,18H,2,4,6-7,12,14H2,(H,25,27)
  • InChiKey: QNIIBMPXWNMFNG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.004 0.0222 0.0215
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0231 0.1097
Echinococcus multilocularis chromobox protein 1 0.0068 0.0491 0.0485
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0022 0.0047 0.0727
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0117 0.0964 0.8201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0114 0.0108
Plasmodium vivax methionine--tRNA ligase, putative 0.0057 0.039 0.6916
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0161 0.0157
Loa Loa (eye worm) hypothetical protein 0.0075 0.0561 0.0561
Mycobacterium tuberculosis Possible penicillin-binding protein 0.048 0.4473 1
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0047 0.0727
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0532 0.0526
Loa Loa (eye worm) hypothetical protein 0.0033 0.015 0.015
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0046 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0561 0.271
Schistosoma mansoni zinc finger protein 0.0019 0.0018 0.0012
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.0964 0.2145
Brugia malayi PHD-finger family protein 0.0024 0.0068 0.0064
Toxoplasma gondii tRNA ligases class I (M) protein 0.0022 0.0047 0.0727
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.0964 0.2145
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.1051 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0104 0.0098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.2131 0.2126
Toxoplasma gondii thioredoxin reductase 0.0051 0.033 0.5836
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0561 1
Schistosoma mansoni methionine-tRNA synthetase 0.0057 0.039 0.0384
Entamoeba histolytica hypothetical protein 0.0072 0.0532 1
Plasmodium falciparum glutathione reductase 0.0051 0.033 0.8438
Entamoeba histolytica hypothetical protein 0.0072 0.0532 1
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0339 0.6003
Brugia malayi chromobox protein homolog 3 0.0038 0.0203 0.0199
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0491 0.237
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0561 1
Chlamydia trachomatis methionine--tRNA ligase 0.0022 0.0047 1
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0561 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0561 0.1241
Brugia malayi Thioredoxin reductase 0.0051 0.033 0.0327
Mycobacterium leprae Probable lipase LipE 0.0075 0.0561 0.244
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.0964 0.2145
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0237 0.2131 0.2131
Echinococcus granulosus histone lysine methyltransferase setb 0.0045 0.0274 0.0268
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0339 0.6003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0114 0.0108
Echinococcus granulosus lamin 0.0033 0.015 0.0144
Loa Loa (eye worm) hypothetical protein 0.0068 0.0497 0.0497
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0491 0.0491
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.109 0.2427
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0274 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0203 0.096
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0203 0.096
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0561 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0237 0.2131 0.2128
Mycobacterium tuberculosis Probable reductase 0.0117 0.0964 0.2145
Onchocerca volvulus 0.0075 0.0561 0.1869
Plasmodium falciparum methionine--tRNA ligase 0.0057 0.039 1
Mycobacterium tuberculosis Conserved protein 0.0075 0.0561 0.1241
Mycobacterium ulcerans beta-lactamase 0.0075 0.0561 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0561 0.0558
Brugia malayi Pre-SET motif family protein 0.0029 0.0114 0.0111
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0046 0.0039
Schistosoma mansoni lamin 0.0033 0.015 0.0144
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0057 0.039 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0561 0.271
Leishmania major hypothetical protein, conserved 0.0075 0.0561 1
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0561 0.1241
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0491 0.237
Loa Loa (eye worm) hypothetical protein 0.0075 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.1051 1 1
Echinococcus granulosus geminin 0.0164 0.1421 0.1415
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0339 0.8679
Onchocerca volvulus 0.0075 0.0561 0.1869
Brugia malayi protein ZK524.3 0.0022 0.0047 0.0043
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0561 1
Onchocerca volvulus 0.0272 0.2464 1
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0561 0.1241
Mycobacterium tuberculosis Conserved protein 0.0075 0.0561 0.1241
Loa Loa (eye worm) intermediate filament protein 0.0033 0.015 0.015
Brugia malayi methionyl-tRNA synthetase 0.0057 0.039 0.0386
Echinococcus multilocularis leucyl tRNA synthetase 0.0022 0.0047 0.004
Entamoeba histolytica hypothetical protein 0.0072 0.0532 1
Onchocerca volvulus 0.0075 0.0561 0.1869
Echinococcus granulosus methionine tRNA synthetase 0.0057 0.039 0.0384
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.2131 0.2126
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0171 0.0165
Brugia malayi methionyl-tRNA synthetase 0.0022 0.0047 0.0043
Brugia malayi Bromodomain containing protein 0.0037 0.0193 0.019
Giardia lamblia Leucyl-tRNA synthetase 0.0022 0.0047 0.1051
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.033 0.0324
Brugia malayi Bromodomain containing protein 0.0073 0.0537 0.0533
Loa Loa (eye worm) hypothetical protein 0.0034 0.0161 0.0161
Giardia lamblia Methionyl-tRNA synthetase 0.0057 0.039 1
Echinococcus granulosus lamin dm0 0.0033 0.015 0.0144
Onchocerca volvulus 0.0229 0.2052 0.824
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.015 0.0146
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0057 0.039 0.039
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0274 0.0268
Echinococcus multilocularis lamin dm0 0.0033 0.015 0.0144
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0561 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0561 0.0555
Trypanosoma brucei trypanothione reductase 0.0051 0.033 0.5836
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.2131 0.2126
Echinococcus multilocularis chromobox protein 1 0.0068 0.0491 0.0485
Loa Loa (eye worm) hypothetical protein 0.0075 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0057 0.039 0.6916
Loa Loa (eye worm) hypothetical protein 0.0052 0.0339 0.0339
Leishmania major hypothetical protein, conserved 0.0052 0.0339 0.6003
Schistosoma mansoni chromobox protein 0.0068 0.0491 0.0485
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0057 0.039 0.0858
Brugia malayi beta-lactamase family protein 0.0075 0.0561 0.0558
Onchocerca volvulus 0.004 0.0222 0.042
Loa Loa (eye worm) hypothetical protein 0.0075 0.0561 0.0561
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0203 0.034
Echinococcus multilocularis musashi 0.0033 0.015 0.0144
Brugia malayi Heterochromatin protein 1 0.0068 0.0491 0.0488
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.003 0.0123 0.0123
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0231 0.0459
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0171 0.0165
Mycobacterium tuberculosis Conserved protein 0.0075 0.0561 0.1241
Echinococcus multilocularis zinc finger protein 0.0019 0.0018 0.0012
Loa Loa (eye worm) hypothetical protein 0.0039 0.0216 0.0216
Schistosoma mansoni methionine-tRNA synthetase 0.0022 0.0047 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0237 0.2131 0.2126
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0045 0.0274 0.0268
Brugia malayi hypothetical protein 0.0034 0.016 0.0157
Leishmania major methionyl-tRNA synthetase, putative 0.0057 0.039 0.6916
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0061 0.0055
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0003 0.0003
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0561 0.0555
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.109 0.2427
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.033 0.5836
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.109 0.2427
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0561 0.1241
Loa Loa (eye worm) beta-lactamase 0.0075 0.0561 0.0561
Mycobacterium ulcerans hypothetical protein 0.0075 0.0561 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.015 0.0144
Schistosoma mansoni hypothetical protein 0.0023 0.0061 0.0055
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0311 0.0308
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0194
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0561 0.0561
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1783 0.1783
Leishmania major trypanothione reductase 0.0051 0.033 0.5836
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0532 0.0526
Loa Loa (eye worm) hypothetical protein 0.0049 0.0311 0.0311
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0028 0.0028
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0046 0.0039
Mycobacterium ulcerans lipase LipD 0.0075 0.0561 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.2131 0.2126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0237 0.2131 0.2126
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0561 0.0555
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0532 0.0526
Entamoeba histolytica hypothetical protein 0.0072 0.0532 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0311 0.0311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0561 0.0555
Brugia malayi glutathione reductase 0.0051 0.033 0.0327
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.0964 0.2145
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0114 0.1945
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0561 0.244
Echinococcus granulosus chromobox protein 1 0.0068 0.0491 0.0485
Onchocerca volvulus 0.0035 0.0178 0.0234
Loa Loa (eye worm) hypothetical protein 0.0038 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0075 0.0561 0.0561
Echinococcus granulosus intermediate filament protein 0.0033 0.015 0.0144
Schistosoma mansoni leucyl-tRNA synthetase 0.0022 0.0047 0.004
Plasmodium vivax glutathione reductase, putative 0.0051 0.033 0.5836
Chlamydia trachomatis leucine--tRNA ligase 0.0022 0.0047 1
Trichomonas vaginalis esterase, putative 0.0075 0.0561 0.271
Leishmania major leucyl-tRNA synthetase, putative 0.0022 0.0047 0.0727
Onchocerca volvulus 0.0033 0.015 0.0113
Wolbachia endosymbiont of Brugia malayi leucyl-tRNA synthetase 0.0022 0.0047 0.1051
Brugia malayi intermediate filament protein 0.0033 0.015 0.0146
Loa Loa (eye worm) hypothetical protein 0.0032 0.0144 0.0144
Brugia malayi beta-lactamase 0.0075 0.0561 0.0558
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0057 0.039 0.1875
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0061 0.0055
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0234
Loa Loa (eye worm) glutathione reductase 0.0051 0.033 0.033
Brugia malayi hypothetical protein 0.0072 0.0532 0.0529
Brugia malayi Pre-SET motif family protein 0.0201 0.1783 0.178
Plasmodium falciparum thioredoxin reductase 0.0051 0.033 0.8438
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0393 0.0387
Toxoplasma gondii ABC1 family protein 0.0075 0.0561 1
Echinococcus multilocularis lamin 0.0033 0.015 0.0144
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0057 0.039 0.6916
Onchocerca volvulus 0.0033 0.015 0.0113
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0237 0.2131 0.2126
Brugia malayi hypothetical protein 0.0052 0.0339 0.0336
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0339 0.6003
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0561 0.1241
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0339 0.6003
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0231 0.1097
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0022 0.0047 0.004
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.1051 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0561 0.271
Treponema pallidum leucyl-tRNA synthetase 0.0022 0.0047 1
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.1051 1 1
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0022 0.0047 0.004
Treponema pallidum methionyl-tRNA synthetase 0.0022 0.0047 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0272 0.2464 0.2464
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0561 0.271
Schistosoma mansoni hypothetical protein 0.0164 0.1421 0.1415
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0339 0.8679
Schistosoma mansoni chromobox protein 0.0068 0.0491 0.0485
Toxoplasma gondii methionyl-tRNA synthetase 0.0057 0.039 0.6916
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.0964 0.2145
Plasmodium vivax SET domain protein, putative 0.0029 0.0114 0.1945
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0311 0.0308
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.033 0.0724
Echinococcus multilocularis methionine tRNA synthetase 0.0057 0.039 0.0384
Plasmodium falciparum methionine--tRNA ligase, putative 0.0022 0.0047 0.1051
Schistosoma mansoni hypothetical protein 0.002 0.0028 0.0022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0561 0.1241
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.033 0.5836
Echinococcus granulosus chromobox protein 1 0.0068 0.0491 0.0485
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2052 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0047 0.0047
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0339 0.6003
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0561 0.1241
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.033 0.033
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0035 0.0178 0.0178
Schistosoma mansoni lamin 0.0033 0.015 0.0144
Schistosoma mansoni hypothetical protein 0.0164 0.1421 0.1415
Schistosoma mansoni bromodomain containing protein 0.0061 0.0427 0.0421
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0435
Echinococcus granulosus zinc finger protein 0.0019 0.0018 0.0012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.015 0.015
Echinococcus multilocularis geminin 0.0164 0.1421 0.1415
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0057 0.039 0.6916
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0393 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0095 0.0435
Brugia malayi beta-lactamase family protein 0.0075 0.0561 0.0558
Plasmodium vivax methionine--tRNA ligase, putative 0.0022 0.0047 0.0727
Schistosoma mansoni hypothetical protein 0.0072 0.0532 0.0526
Loa Loa (eye worm) hypothetical protein 0.0045 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0075 0.0561 0.0561
Brugia malayi Pax transcription factor protein 2 0.0272 0.2464 0.2461
Schistosoma mansoni hypothetical protein 0.0034 0.0161 0.0154
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.109 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.033 0.0324
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0561 0.271

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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