TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 436.484 | Formula: C22H20N4O4S
H donors: 1 H acceptors: 2 LogP: 2.95 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)NC(=O)Cn1c2ccc(cc2c2c1c(=O)n1CCSc1n2)OC
InChi: 1S/C22H20N4O4S/c1-29-14-5-3-4-13(10-14)23-18(27)12-26-17-7-6-15(30-2)11-16(17)19-20(26)21(28)25-8-9-31-22(25)24-19/h3-7,10-11H,8-9,12H2,1-2H3,(H,23,27)
InChiKey: KFKPIVDMZHYRHU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	relaxin/insulin-like family peptide receptor 1	Starlite/ChEMBL	No references
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	snurportin 1		No references
Homo sapiens	arginine vasopressin receptor 1B	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1)	Envelope polyprotein GP160	Starlite/ChEMBL	No references
Homo sapiens	RAN, member RAS oncogene family		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0482	0.1074	0.4521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0164	0.0311	0.1579
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0164	0.0311	0.1579
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0164	0.0311	0.0803
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0049	0.0127
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1023	0.2375	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0712	0.1628	0.6854
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0043	0.002	0.0082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0482	0.1074	0.4521
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0164	0.0311	0.0803
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0164	0.0311	0.1311
Loa Loa (eye worm)	cyclin domain-containing protein	0.0241	0.0495	0.2086
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0164	0.0311	0.0804
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0651	0.148	0.6231
Plasmodium falciparum	glycogen synthase kinase 3	0.0048	0.0031	0.1001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1023	0.2375	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0712	0.1628	0.4204
Plasmodium vivax	protein kinase Crk2	0.0043	0.002	0.0628
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0164	0.0311	0.0803
Trichomonas vaginalis	conserved hypothetical protein	0.0317	0.0679	0.2858
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.002	0.005
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0322	0.1357
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.0048	0.0031	0.0031
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0164	0.0311	0.1579
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0164	0.0311	0.0803
Loa Loa (eye worm)	hypothetical protein	0.0035	0	0.0001
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0311	0.1311
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0164	0.0311	0.1309
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0311	0.0804
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0164	0.0311	0.0311
Trichomonas vaginalis	CMGC family protein kinase	0.0043	0.002	0.0081
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0164	0.0311	0.1311
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Trypanosoma cruzi	cdc2-related kinase 1	0.0043	0.002	0.005
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0035	0	0.0001
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0048	0.0031	0.0131
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0031	0.013
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0164	0.0311	0.0804
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0164	0.0311	0.0803
Echinococcus multilocularis	cyclin dependent kinase 1	0.0043	0.002	0.002
Trypanosoma cruzi	glycogen synthase kinase 3, putative	0.0048	0.0031	0.008
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0311	0.1311
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0395	0.0865	0.2234
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0712	0.1628	0.6854
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0311	0.0804
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0164	0.0311	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0164	0.0311	1
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0164	0.0311	0.0311
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0854	0.1969	0.5255
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0482	0.1074	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0482	0.1074	0.4522
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Schistosoma mansoni	hypothetical protein	0.0372	0.0809	0.209
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0164	0.0311	0.1309
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0537	0.1206	0.5078
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0049	0.0049
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0164	0.0311	0.1579
Plasmodium vivax	glycogen synthase kinase 3, putative	0.0048	0.0031	0.1001
Entamoeba histolytica	hypothetical protein	0.0164	0.0311	0.1579
Giardia lamblia	Kinase, CMGC CDK	0.0043	0.002	0.0098
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0854	0.1969	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0017	0.0073
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0164	0.0311	0.0803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0482	0.1074	0.4521
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0164	0.0311	0.1579
Plasmodium vivax	hypothetical protein	0.0164	0.0311	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0537	0.1206	0.6126
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0311	0.1581
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1647	0.3872	0.3872
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0311	0.0804
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0164	0.0311	0.1579
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0164	0.0311	0.1309
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0854	0.1969	0.8291
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0164	0.0311	0.1309
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Brugia malayi	intracellular kinase	0.0048	0.0031	0.008
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0164	0.0311	0.0311
Echinococcus granulosus	cyclin dependent kinase 5	0.0043	0.002	0.002
Trichomonas vaginalis	CMGC family protein kinase	0.0043	0.002	0.0081
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1647	0.3872	0.3872
Echinococcus multilocularis	cyclin dependent kinase 5	0.0043	0.002	0.002
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0164	0.0311	0.5
Trypanosoma cruzi	target of rapamycin kinase 3	0.0854	0.1969	0.5085
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.0048	0.0031	0.008
Trypanosoma cruzi	cdc2-related kinase 1	0.0043	0.002	0.005
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1647	0.3872	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0854	0.1969	0.5085
Loa Loa (eye worm)	hypothetical protein	0.0164	0.0311	0.1311
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0164	0.0311	1
Giardia lamblia	Kinase, CMGC GSK	0.0048	0.0031	0.0157
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0164	0.0311	0.0804
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0854	0.1969	0.5255
Trypanosoma cruzi	cdc2-related kinase 3	0.0043	0.002	0.005
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0164	0.0311	0.1309
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0164	0.0311	0.0804
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Onchocerca volvulus		0.0164	0.0311	1
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.0048	0.0031	0.0031
Trichomonas vaginalis	CMGC family protein kinase	0.0043	0.002	0.0081
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0164	0.0311	0.1311
Giardia lamblia	Kinase, CMGC CDK	0.0043	0.002	0.0098
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0854	0.1969	0.5255
Toxoplasma gondii	FATC domain-containing protein	0.0712	0.1628	0.8268
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0311	0.1581
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0164	0.0311	0.1579
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0854	0.1969	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0854	0.1969	0.5085
Mycobacterium leprae	conserved hypothetical protein	0.0164	0.0311	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0164	0.0311	0.1579
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0164	0.0311	0.0311
Echinococcus multilocularis	cyclin dependent kinase	0.0043	0.002	0.002
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0164	0.0311	0.0311
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.4198	1	1
Echinococcus multilocularis	protein kinase shaggy	0.0048	0.0031	0.0031
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0164	0.0311	0.1311
Trypanosoma brucei	cdc2-related kinase 3	0.0043	0.002	0.0082
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Brugia malayi	cell division control protein 2 homolog	0.0043	0.002	0.005
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0164	0.0311	0.0803
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0164	0.0311	0.0804
Entamoeba histolytica	cell division protein kinase 2, putative	0.0043	0.002	0.0098
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0164	0.0311	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0164	0.0311	0.1309
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0164	0.0311	0.0311
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0049	0.0049
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0482	0.1074	0.2773
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0164	0.0311	0.083
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0482	0.1074	0.2774
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0164	0.0311	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0049	0.0049
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0164	0.0311	0.083
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0482	0.1074	0.4521
Trypanosoma brucei	cdc2-related kinase 1	0.0043	0.002	0.0082
Echinococcus multilocularis	cyclin dependent kinase 1	0.0043	0.002	0.002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0311	0.1581
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0164	0.0311	1
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0043	0.002	0.0099
Giardia lamblia	Hypothetical protein	0.0164	0.0311	0.1579
Onchocerca volvulus		0.0164	0.0311	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0164	0.0311	0.0804
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1023	0.2375	0.6339
Loa Loa (eye worm)	cyclin domain-containing protein	0.0035	0	0.0001
Trypanosoma cruzi	hypothetical protein, conserved	0.143	0.3351	0.8655
Brugia malayi	RNA, U transporter 1	0.0099	0.0154	0.0398
Trichomonas vaginalis	CMGC family protein kinase	0.0048	0.0031	0.013
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0049	0.0049
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0854	0.1969	0.5085
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0548	0.1233	0.3184
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0373	0.0811	0.0811
Plasmodium vivax	hypothetical protein, conserved	0.0164	0.0311	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.2269	0.2269
Schistosoma mansoni	hypothetical protein	0.0164	0.0311	0.0804
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0164	0.0311	0.1309
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0164	0.0311	0.1309
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0854	0.1969	0.8291
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0482	0.1074	0.4521
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0311	0.0804
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0854	0.1969	0.8291
Onchocerca volvulus		0.0048	0.0031	0.0991
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0164	0.0311	0.0804
Trichomonas vaginalis	conserved hypothetical protein	0.0373	0.0811	0.3415
Loa Loa (eye worm)	phosphatidylinositol 3	0.1023	0.2375	1
Entamoeba histolytica	protein kinase, putative	0.0048	0.0031	0.0157
Schistosoma mansoni	cyclin B3	0.0035	0	0.0001
Entamoeba histolytica	hypothetical protein	0.0712	0.1628	0.8267
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0164	0.0311	0.1309
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0164	0.0311	0.1311
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0043	0.002	0.0051
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1647	0.3872	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0043	0.002	0.005
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0311	0.1311
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0854	0.1969	0.1969
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0164	0.0311	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0164	0.0311	0.1309
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0854	0.1969	0.5255
Echinococcus granulosus	cyclin dependent kinase 1	0.0043	0.002	0.002
Leishmania major	hypothetical protein, conserved	0.1594	0.3746	1
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0311	0.1581
Schistosoma mansoni	cyclin B	0.0035	0	0.0001
Brugia malayi	Protein kinase domain containing protein	0.0043	0.002	0.005
Loa Loa (eye worm)	hypothetical protein	0.0373	0.0811	0.3416
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0712	0.1628	0.4204
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0164	0.0311	0.1311
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0164	0.0311	0.0803
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0164	0.0311	0.0803
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0537	0.1206	0.5079
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0164	0.0311	0.0311
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0043	0.002	0.002
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0164	0.0311	0.1309
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0035	0	0.0001
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0049	0.0207
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0164	0.0311	0.0311
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0317	0.0679	0.2858
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0311	0.1311
Entamoeba histolytica	hypothetical protein	0.0164	0.0311	0.1579
Loa Loa (eye worm)	phosphatidylinositol 3	0.0854	0.1969	0.8291
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0482	0.1074	0.1074
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0311	0.1311
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0651	0.148	0.7516
Brugia malayi	FAT domain containing protein	0.0373	0.0811	0.2095
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0164	0.0311	0.1581
Echinococcus multilocularis	Zinc finger, PHD finger	0.0164	0.0311	0.0311
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0164	0.0311	0.0804
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0164	0.0311	0.1309
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1647	0.3872	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0164	0.0311	0.1309
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0164	0.0311	0.1309
Loa Loa (eye worm)	phosphatidylinositol 3	0.0164	0.0311	0.1311
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0049	0.0127
Leishmania major	hypothetical protein, unknown function	0.0164	0.0311	0.083
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0164	0.0311	0.1309
Loa Loa (eye worm)	hypothetical protein	0.0548	0.1233	0.5192
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0043	0.002	0.0082
Schistosoma mansoni	cyclins	0.0035	0	0.0001
Echinococcus granulosus	snurportin 1	0.0372	0.0809	0.0809
Echinococcus multilocularis	serine protein kinase ATM	0.0712	0.1628	0.1628
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.0048	0.0031	0.0158
Schistosoma mansoni	hypothetical protein	0.0373	0.0811	0.2095
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0035	0	0.0001
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0164	0.0311	0.1579
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0164	0.0311	0.0311
Echinococcus granulosus	serine protein kinase ATM	0.0712	0.1628	0.1628
Trypanosoma brucei	mitotic cyclin 6	0.0035	0	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0049	0.0127
Plasmodium falciparum	protein kinase 5	0.0043	0.002	0.0628
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0311	0.0804
Loa Loa (eye worm)	hypothetical protein	0.0035	0	0.0001
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0395	0.0865	0.2309
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1647	0.3872	1
Trichomonas vaginalis	conserved hypothetical protein	0.0537	0.1206	0.5078
Trypanosoma brucei	protein kinase, putative	0.0048	0.0031	0.0131
Giardia lamblia	GTOR	0.0854	0.1969	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0164	0.0311	0.1311
Entamoeba histolytica	protein kinase rad3, putative	0.0482	0.1074	0.5454
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0854	0.1969	0.1969
Giardia lamblia	Kinase, CMGC GSK	0.0048	0.0031	0.0157
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0854	0.1969	0.5085
Loa Loa (eye worm)	hypothetical protein	0.0537	0.1206	0.5079
Echinococcus granulosus	cyclin dependent kinase	0.0043	0.002	0.002
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0043	0.002	0.0082
Echinococcus granulosus	protein kinase shaggy	0.0048	0.0031	0.0031
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	0.0048	0.0031	0.0082
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0164	0.0311	0.0804
Entamoeba histolytica	hypothetical protein	0.0164	0.0311	0.1579
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0164	0.0311	0.1579
Entamoeba histolytica	cell division protein kinase 2, putative	0.0043	0.002	0.0098
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0712	0.1628	0.4204
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0482	0.1074	0.4521
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0373	0.0811	0.0811
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0164	0.0311	0.1309
Plasmodium falciparum	cyclin	0.0035	0	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0169	0.0322	0.1357
Echinococcus multilocularis		0.0164	0.0311	0.0311
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0049	0.0127
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0164	0.0311	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0164	0.0311	0.0311
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0854	0.1969	0.8291
Entamoeba histolytica	protein kinase domain containing protein	0.0048	0.0031	0.0157
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0164	0.0311	0.0311
Echinococcus multilocularis	snurportin 1	0.0372	0.0809	0.0809
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0482	0.1074	0.2774
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.0809	0.3408
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0854	0.1969	0.829
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0164	0.0311	0.0311
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0854	0.1969	1
Entamoeba histolytica	protein kinase domain containing protein	0.0048	0.0031	0.0157
Leishmania major	phosphatidylinositol kinase, putative	0.0164	0.0311	0.083
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0043	0.002	0.0051
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0241	0.0495	0.1279
Entamoeba histolytica	hypothetical protein	0.0164	0.0311	0.1579
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.0048	0.0031	0.0131
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0164	0.0311	0.1579
Schistosoma mansoni	serine/threonine protein kinase	0.0043	0.002	0.005

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	8.952 uM	PubChem BioAssay. Counterscreen for discovery of small molecules that bind to the HIV-1-gp120 binding antibody, PG9: TR-FRET-based biochemical high throughput dose response assay to identify small molecules that bind to the control antibody, PGV04, which binds to a distinct site on the HIV envelope different from the PG9 binding site. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	11.178 uM	PubChem BioAssay. Counterscreen for discovery of small molecules that bind to the HIV-1-gp120 binding antibody, PG9: TR-FRET-based biochemical high throughput dose response assay to identify small molecules that bind to the control antibody, PG126, which binds to a distinct site on the HIV envelope different from the PG9 binding site. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	67.04 uM	PubChem BioAssay. TRFRET-based biochemical high throughput dose response assay for small molecules that bind to the HIV-1-gp120 binding antibody, PG9. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.5805 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	2.31 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	3.0881 uM	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: THP1 Hit Validation. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 5.0119 um	PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.2648 uM	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: V1B Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.5113 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	17.3245 uM	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP1 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489043, AID492948]	ChEMBL.	No reference
Potency (functional)	21.8103 uM	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1: RXFP2 Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2676, AID2703, AID489012]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	32.6294 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Saccharomyces cerevisiae	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1379032

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1269902