Detailed information for compound 1290521

Basic information

Technical information
  • TDR Targets ID: 1290521
  • Name: N-[(2-fluorophenyl)methyl]-3-[1-(furan-2-carb onyl)piperidin-3-yl]propanamide
  • MW: 358.407 | Formula: C20H23FN2O3
  • H donors: 1 H acceptors: 2 LogP: 2.73 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NCc1ccccc1F)CCC1CCCN(C1)C(=O)c1ccco1
  • InChi: 1S/C20H23FN2O3/c21-17-7-2-1-6-16(17)13-22-19(24)10-9-15-5-3-11-23(14-15)20(25)18-8-4-12-26-18/h1-2,4,6-8,12,15H,3,5,9-11,13-14H2,(H,22,24)
  • InChiKey: VOKZBVCNVYEEJN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-fluorophenyl)methyl]-3-[1-(furan-2-carbonyl)-3-piperidyl]propanamide
  • N-[(2-fluorophenyl)methyl]-3-[1-(2-furyl-oxomethyl)-3-piperidinyl]propanamide
  • N-(2-fluorobenzyl)-3-[1-(furan-2-carbonyl)-3-piperidyl]propionamide
  • N-[(2-fluorophenyl)methyl]-3-(1-furan-2-ylcarbonylpiperidin-3-yl)propanamide
  • SMR000315389
  • MLS000733511
  • N-(2-fluorobenzyl)-3-[1-(2-furoyl)piperidin-3-yl]propanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1562 0.5168
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0221 0.0428
Loa Loa (eye worm) hypothetical protein 0.0145 0.0851 0.2249
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0851 0.2655
Schistosoma mansoni smad1 5 8 and 0.0024 0.0081 0.0126
Onchocerca volvulus 0.0145 0.0851 0.2745
Schistosoma mansoni coup transcription factor 0.0021 0.0064 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1562 0.5168
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0547 0.0853
Mycobacterium tuberculosis Conserved protein 0.0145 0.0851 0.1255
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0064 0.0251
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0306 0.0477
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0239 0.0239
Echinococcus granulosus snurportin 1 0.0606 0.3783 0.5897
Brugia malayi latrophilin 2 splice variant baaae 0.0235 0.1423 0.5547
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0133 0.0774 0.1206
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1 0.3182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0064 0.01
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0192 0.0326
Brugia malayi MH2 domain containing protein 0.0024 0.0081 0.0314
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0162 0.022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0064 0.01
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0554 0.0863
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0851 0.2655
Loa Loa (eye worm) hypothetical protein 0.0145 0.0851 0.2249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0133 0.0774 0.0774
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0282 0.0439
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0064 0.0064
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0194 0.0302
Brugia malayi hypothetical protein 0.0032 0.0132 0.0514
Echinococcus granulosus geminin 0.102 0.6415 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0064 0.01
Onchocerca volvulus 0.0297 0.1816 0.6114
Loa Loa (eye worm) hypothetical protein 0.0061 0.0317 0.0837
Loa Loa (eye worm) hypothetical protein 0.0038 0.017 0.045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0306 0.2097
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0064 0.01
Schistosoma mansoni inositol monophosphatase 0.0037 0.0162 0.0252
Schistosoma mansoni ran 0.0042 0.0194 0.0302
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0064 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1562 0.5168
Brugia malayi MH1 domain containing protein 0.0013 0.0012 0.0048
Brugia malayi beta-lactamase 0.0145 0.0851 0.3317
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0151 0.0235
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.1424 0.1424
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1 0.3182
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0239 0.0372
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0064 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0064 0.0064
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0244 0.0794
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.1152 0.1796
Trichomonas vaginalis chromobox protein, putative 0.0068 0.036 0.0921
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0244 0.1194
Schistosoma mansoni hypothetical protein 0.0109 0.062 0.0966
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0133 0.0774 0.0774
Loa Loa (eye worm) latrophilin receptor protein 2 0.0109 0.062 0.1639
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0152 0.0896 0.1347
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1058 0.3386
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0162 0.022
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0544 0.0848
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0158 0.0158
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0109 0.062 0.0966
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0306 0.0306
Mycobacterium tuberculosis Probable hydrolase 0.0145 0.0851 0.1255
Brugia malayi hypothetical protein 0.0035 0.0151 0.0589
Loa Loa (eye worm) hypothetical protein 0.0051 0.0252 0.0666
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0244 0.6227
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0064 0.01
Onchocerca volvulus 0.0145 0.0851 0.2745
Brugia malayi Pre-SET motif family protein 0.0415 0.2565 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0292 0.0456
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0498
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0192 0.03
Echinococcus granulosus muscleblind protein 0.0147 0.0863 0.1345
Schistosoma mansoni patched 1 0.0042 0.0192 0.03
Trypanosoma brucei hypothetical protein, conserved 0.0145 0.0851 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0194 0.0194
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0064 0.0064
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0133 0.0774 0.2045
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0064 0.0251
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1 0.3182
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0221 0.0428
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0064 0.0251
Echinococcus granulosus GPCR family 2 0.0109 0.062 0.0966
Loa Loa (eye worm) hypothetical protein 0.003 0.0118 0.0311
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0064 0.0064
Echinococcus multilocularis geminin 0.102 0.6415 0.6415
Schistosoma mansoni importin beta-1 0.0057 0.0289 0.045
Echinococcus multilocularis protein patched 0.0042 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0056 0.0286 0.0756
Brugia malayi RNA, U transporter 1 0.0161 0.0955 0.3722
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0244 0.1194
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0162 0.5
Brugia malayi beta-lactamase family protein 0.0145 0.0851 0.3317
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0851 0.1326
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0064 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0244 0.1194
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0192 0.0299
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0498
Schistosoma mansoni protein phosphatase 1 inhibitor potentiated by protein kinase C 0.0056 0.0286 0.0446
Echinococcus granulosus smad 0.0024 0.0081 0.0126
Plasmodium vivax importin-beta 2, putative 0.0057 0.0289 0.1478
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0244 0.6227
Brugia malayi hypothetical protein 0.0235 0.1424 0.5552
Loa Loa (eye worm) Smad1 0.0024 0.0081 0.0213
Loa Loa (eye worm) transcription factor SMAD2 0.0352 0.2169 0.5733
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0233 0.0909
Echinococcus granulosus Smad4 0.0024 0.0081 0.0126
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0282 0.0282
Plasmodium falciparum importin beta, putative 0.0057 0.0289 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0282 0.0439
Loa Loa (eye worm) MH2 domain-containing protein 0.0352 0.2169 0.5733
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0064 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.017
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0162 0.022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0145 0.0851 0.1255
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0851 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0081 0.0126
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0064 0.01
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0799 0.1246
Echinococcus granulosus chromobox protein 1 0.0068 0.036 0.0561
Echinococcus granulosus chromobox protein 1 0.0068 0.036 0.0561
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0064 0.0064
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0151 0.0235
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0145 0.0851 0.2249
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0194 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0544 0.2122
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0109 0.062 0.062
Schistosoma mansoni protein kinase 0.0244 0.1481 0.2309
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0064 0.0251
Mycobacterium tuberculosis Conserved protein 0.0145 0.0851 0.1255
Schistosoma mansoni hypothetical protein 0.0297 0.1817 0.2831
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0064 0.01
Schistosoma mansoni smad 0.0024 0.0081 0.0126
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0239 0.0239
Brugia malayi hypothetical protein 0.0297 0.1816 0.708
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0526 0.0821
Loa Loa (eye worm) hypothetical protein 0.0056 0.0282 0.0744
Brugia malayi RNA binding protein 0.0062 0.032 0.1246
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.017
Brugia malayi mbt repeat family protein 0.0049 0.0239 0.093
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0194 0.0465
Schistosoma mansoni hypothetical protein 0.0109 0.062 0.0966
Leishmania major importin beta-1 subunit, putative 0.0046 0.0221 0.0857
Brugia malayi hypothetical protein 0.0056 0.0286 0.1115
Loa Loa (eye worm) RNA binding protein 0.0062 0.032 0.0845
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0547 0.0853
Loa Loa (eye worm) hypothetical protein 0.0033 0.0138 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.017 0.025
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0863 0.0863
Echinococcus multilocularis snurportin 1 0.0606 0.3783 0.3783
Mycobacterium ulcerans hypothetical protein 0.0145 0.0851 0.1264
Mycobacterium tuberculosis Probable lipase LipD 0.0145 0.0851 0.1255
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0145 0.0851 0.1255
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.1562 0.4129
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.2565 0.6781
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0851 0.2655
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0064 0.01
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.017
Schistosoma mansoni hypothetical protein 0.0109 0.062 0.0966
Loa Loa (eye worm) TAR-binding protein 0.0062 0.032 0.0845
Schistosoma mansoni ran 0.0042 0.0194 0.0302
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.1152 0.1152
Loa Loa (eye worm) inositol-1 0.0037 0.0162 0.0427
Mycobacterium tuberculosis Probable esterase LipL 0.0145 0.0851 0.1255
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0825 0.1285
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0064 0.0251
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0064 0.01
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0081 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0064 0.017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0033
Echinococcus granulosus PKC activated phosphatase 1 inhibitor 0.0056 0.0286 0.0446
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0192 0.0326
Echinococcus multilocularis chromobox protein 1 0.0068 0.036 0.036
Schistosoma mansoni hypothetical protein 0.0022 0.007 0.0109
Mycobacterium leprae conserved hypothetical protein 0.0145 0.0851 0.1303
Entamoeba histolytica Ran family GTPase 0.0042 0.0194 0.1083
Schistosoma mansoni hypothetical protein 0.004 0.0183 0.0285
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0064 0.01
Schistosoma mansoni hypothetical protein 0.004 0.0183 0.0285
Echinococcus multilocularis protein dispatched 1 0.0047 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0109 0.062 0.1639
Trichomonas vaginalis D-aminoacylase, putative 0.0145 0.0851 0.2655
Schistosoma mansoni chromobox protein 0.0068 0.036 0.0561
Loa Loa (eye worm) hypothetical protein 0.0344 0.2115 0.5591
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0071 0.0377 0.0588
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0145 0.0851 0.1326
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0109 0.062 0.0966
Loa Loa (eye worm) hypothetical protein 0.0145 0.0851 0.2249
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.1058 0.3386
Mycobacterium leprae Probable lipase LipE 0.0145 0.0851 0.1303
Brugia malayi Inositol-1 0.0037 0.0162 0.063
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0239 0.0631
Brugia malayi MH2 domain containing protein 0.0024 0.0081 0.0314
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0239 0.0372
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0133 0.0774 0.3016
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0239 0.0372
Mycobacterium tuberculosis Conserved protein 0.0145 0.0851 0.1255
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.007 0.0109
Schistosoma mansoni hypothetical protein 0.004 0.0183 0.0285
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.1 0.3266
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0544 0.0544
Brugia malayi MH1 domain containing protein 0.0013 0.0012 0.0048
Mycobacterium ulcerans lipase LipD 0.0145 0.0851 0.1264
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0064 0.01
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0064 0.01
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0344 0.2115 0.8245
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0544 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0306 0.0477
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.1562 0.6089
Leishmania major hypothetical protein, conserved 0.005 0.0244 0.1194
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.017
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0158 0.0247
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0162 0.0268
Loa Loa (eye worm) hypothetical protein 0.0097 0.0547 0.1446
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0825 0.0825
Schistosoma mansoni hypothetical protein 0.0109 0.062 0.0966
Plasmodium vivax hypothetical protein, conserved 0.0145 0.0851 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0498
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0064 0.0251
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0081 0.0126
Onchocerca volvulus 0.0145 0.0851 0.2745
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0064 0.01
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0239 0.0372
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0064 0.0251
Loa Loa (eye worm) hypothetical protein 0.0059 0.0306 0.0809
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1 0.3182
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0337 0.0526
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0064 0.0251
Loa Loa (eye worm) hypothetical protein 0.0057 0.0289 0.0764
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0194 0.0465
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0289 0.1848
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0239 0.0608
Loa Loa (eye worm) hypothetical protein 0.0147 0.0863 0.2282
Loa Loa (eye worm) hypothetical protein 0.0145 0.0851 0.2249
Toxoplasma gondii ABC1 family protein 0.0145 0.0851 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0189 0.0433
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0064 0.017
Echinococcus multilocularis chromobox protein 1 0.0068 0.036 0.036
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0289 0.1848
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.032 0.0845
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1562 0.5168
Onchocerca volvulus 0.0472 0.293 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0282 0.0282
Schistosoma mansoni hypothetical protein 0.0235 0.1423 0.2218
Brugia malayi chromobox protein homolog 3 0.0038 0.017 0.0663
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.1424 0.222
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0221 0.0428
Brugia malayi Muscleblind-like protein 0.0147 0.0863 0.3365
Trichomonas vaginalis esterase, putative 0.0145 0.0851 0.2655
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0064 0.0064
Trichomonas vaginalis ran, putative 0.0042 0.0194 0.0333
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0192 0.0509
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0194 0.0512
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0244 0.1481 0.2309
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0064 0.01
Loa Loa (eye worm) hypothetical protein 0.005 0.0244 0.0645
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0306 0.0477
Brugia malayi TAR-binding protein 0.0062 0.032 0.1246
Schistosoma mansoni hypothetical protein 0.102 0.6415 1
Echinococcus multilocularis expressed conserved protein 0.0091 0.0507 0.0507
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0109 0.062 0.2416
Entamoeba histolytica hypothetical protein 0.0046 0.0221 0.1771
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1 0.3182
Schistosoma mansoni transient receptor potential channel 0.0064 0.0337 0.0526
Brugia malayi nuclear hormone receptor 0.0021 0.0064 0.0251
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0064 0.01
Schistosoma mansoni hypothetical protein 0.004 0.0183 0.0285
Loa Loa (eye worm) hypothetical protein 0.0042 0.0192 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0064 0.0251
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0064 0.0064
Schistosoma mansoni transient receptor potential channel 0.0064 0.0337 0.0526
Loa Loa (eye worm) nuclear factor I 0.0013 0.0012 0.0033
Trichomonas vaginalis penicillin-binding protein, putative 0.0145 0.0851 0.2655
Loa Loa (eye worm) hypothetical protein 0.0147 0.0863 0.2282
Brugia malayi hypothetical protein 0.005 0.0244 0.0951
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0239 0.0372
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1562 0.5168
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0825 0.3214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.0774 0.1206
Brugia malayi Pre-SET motif family protein 0.0059 0.0306 0.1193
Brugia malayi Heterochromatin protein 1 0.0068 0.036 0.1404
Loa Loa (eye worm) hypothetical protein 0.0049 0.0239 0.0631
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0498
Brugia malayi steroid hormone receptor 0.0021 0.0064 0.0251
Loa Loa (eye worm) beta-lactamase 0.0145 0.0851 0.2249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0133 0.0774 0.1206
Plasmodium vivax SET domain protein, putative 0.0059 0.0306 0.1738
Onchocerca volvulus 0.0048 0.0233 0.0589
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0194 0.0465
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0158 0.0616
Echinococcus multilocularis smad 0.0024 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.0048 0.0233 0.0363
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0194 0.0755
Echinococcus multilocularis muscleblind protein 0.0147 0.0863 0.0863
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0189 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0064 0.0251
Echinococcus multilocularis beta LACTamase domain containing family member 0.0145 0.0851 0.0851
Schistosoma mansoni chromobox protein 0.0068 0.036 0.0561
Echinococcus multilocularis PKC activated phosphatase 1 inhibitor 0.0056 0.0286 0.0286
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0162 0.0162
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0282 0.1097
Loa Loa (eye worm) acetyltransferase 0.0141 0.0825 0.218
Schistosoma mansoni transient receptor potential channel 0.0097 0.0547 0.0853
Trichomonas vaginalis set domain proteins, putative 0.0472 0.293 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.0774 0.1206
Trypanosoma cruzi hypothetical protein, conserved 0.0145 0.0851 1
Schistosoma mansoni hypothetical protein 0.0606 0.3783 0.5897
Trichomonas vaginalis chromobox protein, putative 0.0068 0.036 0.0921
Schistosoma mansoni protein kinase 0.0244 0.1481 0.2309
Schistosoma mansoni survival motor neuron protein 0.0048 0.0233 0.0363
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0064 0.017
Brugia malayi Calcitonin receptor-like protein seb-1 0.0344 0.2115 0.8245
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0189 0.0315
Mycobacterium tuberculosis Probable lipase LipE 0.0145 0.0851 0.1255
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0192 0.0192
Brugia malayi beta-lactamase family protein 0.0145 0.0851 0.3317
Brugia malayi nuclear receptor NHR-88 0.0021 0.0064 0.0251
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0151 0.0151
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0064 0.01
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0282 0.0439
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0192 0.0329
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0145 0.0851 0.1255
Onchocerca volvulus 0.003 0.0118 0.0186
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0606 0.3783 1
Leishmania major hypothetical protein, conserved 0.0145 0.0851 1
Schistosoma mansoni smad1 5 8 and 0.0024 0.0081 0.0126
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0244 0.1481 0.1481
Loa Loa (eye worm) hypothetical protein 0.0235 0.1423 0.3762
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0289 0.0289
Brugia malayi ecdysteroid receptor 0.0021 0.0064 0.0251
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0064 0.017
Echinococcus granulosus tar DNA binding protein 0.0062 0.032 0.0498
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.036 0.0952
Brugia malayi Importin beta-1 subunit 0.0057 0.0289 0.1126
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1562 0.5168
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.017
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0194 0.0465
Echinococcus granulosus beta LACTamase domain containing family member 0.0145 0.0851 0.1326
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0064 0.0251
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0145 0.0851 0.3317
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0337 0.0337
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0064 0.0251
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0547 0.0547
Leishmania major GTP-binding protein, putative 0.0042 0.0194 0.0465
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0192 0.0434
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0221 0.0857
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0064 0.01
Schistosoma mansoni Smad4 0.0024 0.0081 0.0126
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0064 0.0251
Brugia malayi mbt repeat family protein 0.0049 0.0239 0.093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0064 0.0251
Brugia malayi MH1 domain containing protein 0.0024 0.0081 0.0314
Brugia malayi MH2 domain containing protein 0.0352 0.2169 0.8454
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0526 0.0526
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0244 0.1194
Echinococcus granulosus expressed conserved protein 0.0091 0.0507 0.079
Brugia malayi Smad1 0.0024 0.0081 0.0314
Echinococcus granulosus importin subunit beta 1 0.0057 0.0289 0.045
Echinococcus multilocularis tar DNA binding protein 0.0062 0.032 0.032
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0306 0.0306
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0809 0.1261
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0064 0.0251
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0081 0.0213
Schistosoma mansoni inositol monophosphatase 0.0037 0.0162 0.0252
Onchocerca volvulus 0.0049 0.0239 0.0608
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0194 0.2015
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.032 0.1246
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0192 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0064 0.0251
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1 0.3182
Echinococcus multilocularis GPCR, family 2 0.0109 0.062 0.062
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0081 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.1 0.3182
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0081 0.0213
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0927 0.5826 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0306 0.0477
Echinococcus multilocularis Smad4 0.0024 0.0081 0.0081
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.017 0.0471
Brugia malayi SET domain containing protein 0.0013 0.0013 0.0049
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0337 0.0337
Schistosoma mansoni tar DNA-binding protein 0.0062 0.032 0.0498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0064 0.017
Brugia malayi Latrophilin receptor protein 2 0.0109 0.062 0.2416
Mycobacterium ulcerans beta-lactamase 0.0145 0.0851 0.1264
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0337 0.0526
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0344 0.2115 0.5591
Schistosoma mansoni hypothetical protein 0.102 0.6415 1
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0064 0.01
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0194 0.0032
Loa Loa (eye worm) hypothetical protein 0.0145 0.0851 0.2249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0133 0.0774 0.1206
Loa Loa (eye worm) MBCTL1 0.0056 0.0282 0.0744
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0109 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.017
Mycobacterium ulcerans esterase/lipase LipP 0.0145 0.0851 0.1264
Loa Loa (eye worm) hypothetical protein 0.0235 0.1424 0.3765
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0162 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.017 0.025
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0064 0.01
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0809 0.0809
Schistosoma mansoni smad1 5 8 and 0.0024 0.0081 0.0126
Brugia malayi CHE-14 protein 0.0042 0.0192 0.075
Onchocerca volvulus 0.0071 0.0377 0.1091
Mycobacterium tuberculosis Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) 0.0894 0.5615 0.9629
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0145 0.0851 0.2249
Onchocerca volvulus 0.0056 0.0286 0.0773
Loa Loa (eye worm) hypothetical protein 0.0297 0.1816 0.4801
Schistosoma mansoni hypothetical protein 0.0035 0.0151 0.0235
Mycobacterium ulcerans naphthoate synthase 0.0894 0.5615 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0192 0.03
Loa Loa (eye worm) hypothetical protein 0.0036 0.0158 0.0418
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0081 0.0126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0064 0.017
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0289 0.1848
Brugia malayi MH1 domain containing protein 0.0024 0.0081 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0064 0.017
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0097 0.0544 0.1439
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.017 0.0369
Mycobacterium leprae PROBABLE NAPHTHOATE SYNTHASE MENB (DIHYDROXYNAPHTHOIC ACID SYNTHETASE) (DHNA SYNTHETASE) 0.0894 0.5615 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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