Detailed information for compound 1294641

Basic information

Technical information
  • TDR Targets ID: 1294641
  • Name: 2-(1-cyclohexyltetrazol-5-yl)sulfanyl-1-(3-me thoxyphenyl)ethanone
  • MW: 332.421 | Formula: C16H20N4O2S
  • H donors: 0 H acceptors: 4 LogP: 3.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)C(=O)CSc1nnnn1C1CCCCC1
  • InChi: 1S/C16H20N4O2S/c1-22-14-9-5-6-12(10-14)15(21)11-23-16-17-18-19-20(16)13-7-3-2-4-8-13/h5-6,9-10,13H,2-4,7-8,11H2,1H3
  • InChiKey: NHSOYLRSNVOECA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(1-cyclohexyl-5-tetrazolyl)thio]-1-(3-methoxyphenyl)ethanone
  • 2-[(1-cyclohexyltetrazol-5-yl)thio]-1-(3-methoxyphenyl)ethanone
  • 2-[(1-cyclohexyl-1,2,3,4-tetrazol-5-yl)sulfanyl]-1-(3-methoxyphenyl)ethanone
  • ASN 04891400
  • ZINC01340455
  • MLS000122491
  • SMR000119823
  • 2-(1-Cyclohexyl-1H-tetrazol-5-ylsulfanyl)-1-(3-methoxy-phenyl)-ethanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0277 0.1254
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0527 0.1855
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0019 0.0241 0.0098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0893 0.3628
Schistosoma mansoni protein kinase 0.0032 0.0553 0.198
Trypanosoma brucei glucose transporter, putative 0.0032 0.0551 0.4432
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0646 0.098
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Leishmania major glucose transporter, lmgt1 0.0032 0.0551 0.3616
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0241 0.1091
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0217
Trypanosoma brucei glucose transporter, putative 0.0032 0.0551 0.4432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0241 0.1091
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0343 0.0519
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0343 0.0961
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.099 0.4488
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0551 0.4432
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.1062 0.4451
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1062 0.4814
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0527 0.2388
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0553 0.198
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1524 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0646 0.5467
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0343 0.0961
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0014 0.0144 0.0144
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1524 0.6692
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0019 0.0241 0.0365
Trypanosoma cruzi glucose transporter, putative 0.0014 0.0144 0.136
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0241 0.1579
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0852 0.386
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0527 0.5517
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0343 0.1923
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0343 0.2248
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0742 1
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0646 0.4239
Schistosoma mansoni protein kinase 0.0032 0.0553 0.198
Toxoplasma gondii DNA polymerase family B protein 0.0019 0.0241 0.0365
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0646 0.6084
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0019 0.0241 0.1048
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.2206 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Loa Loa (eye worm) hypothetical protein 0.0023 0.0343 0.1553
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.099 0.4101
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0019 0.0241 0.2265
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0852 0.8019
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0646 0.0509
Mycobacterium ulcerans sugar transporter 0.0014 0.0144 0.0568
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0852 0.5587
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0527 0.1855
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0551 0.4432
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0019 0.0241 0.0466
Schistosoma mansoni glucose transport protein 0.0102 0.2206 1
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0019 0.0241 0.0466
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0553 0.198
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0553 0.0839
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Toxoplasma gondii DNA polymerase 0.0019 0.0241 0.0365
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0019 0.0241 0.0466
Trypanosoma brucei glucose transporter, putative 0.0032 0.0551 0.4432
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0553 0.2505
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0019 0.0241 0.0466
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0019 0.0241 0.0466
Loa Loa (eye worm) sugar transporter 0.0014 0.0144 0.0655
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0241 0.2265
Toxoplasma gondii facilitative glucose transporter GT1 0.0102 0.2206 0.3345
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0217
Echinococcus multilocularis General substrate transporter 0.0088 0.1869 0.8364
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.099 0.4101
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0019 0.0241 0.0466
Toxoplasma gondii protein kinase, putative 0.029 0.6596 1
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0496 0.1707
Brugia malayi DNA polymerase alpha catalytic subunit 0.0019 0.0241 0.0466
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1524 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0262 0.0851
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2206 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0019 0.0241 0.1579
Brugia malayi DNA polymerase family B containing protein 0.0019 0.0241 0.0466
Trichomonas vaginalis myo-inositol transporter, putative 0.0014 0.0144 0.0655
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0646 0.0646
Mycobacterium ulcerans integral membrane transport protein 0.0014 0.0144 0.0568
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1524 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0527 0.1855
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0019 0.0241 0.2265
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0553 0.0415
Loa Loa (eye worm) hypothetical protein 0.0051 0.099 0.4488
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.1062 0.4451
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.1062 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0551 0.519
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0551 0.4432
Trypanosoma brucei glucose transporter 1E 0.0032 0.0551 0.4432
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Toxoplasma gondii transporter, major facilitator family protein 0.0014 0.0144 0.0219
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0014 0.0144 0.0568
Brugia malayi Inositol-1 0.0045 0.0852 0.343
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0019 0.0241 0.0466
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2206 1
Toxoplasma gondii sugar transporter ST1 0.0014 0.0144 0.0219
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0553 0.198
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.001 0.0048 0.0217
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3695 0.3695
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0019 0.0241 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.1062 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0852 0.343
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.1062 1
Schistosoma mansoni hypothetical protein 0.0016 0.0181 0.0179
Leishmania major glucose transporter, lmgt2 0.0032 0.0551 0.3616
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0527 0.6187
Schistosoma mansoni inositol monophosphatase 0.0045 0.0852 0.343
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0527 0.1855
Trypanosoma cruzi sugar transporter, putative 0.0014 0.0144 0.136
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0852 0.5402
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0852 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3695 0.3602
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.001 0.0048 0.0048
Brugia malayi MAP kinase sur-1 0.0054 0.1062 0.4451
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0343 0.0961
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0214 0.2014
Trypanosoma brucei glucose transporter, putative 0.0032 0.0551 0.4432
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1524 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0527 0.4961
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0553 0.4449
Brugia malayi Sugar transporter family protein 0.0102 0.2206 1
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0343 0.0343
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0646 0.6084
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1524 0.6692
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3695 0.5601
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0852 0.386
Trypanosoma cruzi hexose transporter, putative 0.0014 0.0144 0.136
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0343 0.0201
Schistosoma mansoni glucose transport protein 0.0102 0.2206 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0019 0.0241 0.1091
Trypanosoma brucei glucose transporter, putative 0.0032 0.0551 0.4432
Brugia malayi DNA polymerase delta catalytic subunit 0.0019 0.0241 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0553 0.0415
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0553 0.0553
Entamoeba histolytica protein kinase, putative 0.0032 0.0553 0.649
Trichomonas vaginalis DNA polymerase II, putative 0.0019 0.0241 0.1091
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0551 0.2498
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0019 0.0241 1
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0551 0.3616
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0019 0.0241 0.0466
Leishmania major protein kinase, putative 0.0032 0.0553 0.3626
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0343 0.3226
Loa Loa (eye worm) sugar transporter 0.0102 0.2206 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0852 0.386
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0852 0.8019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0527 0.2388
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0019 0.0241 0.1048
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0553 0.0839
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0893 0.3628
Echinococcus multilocularis GPCR, family 2 0.0016 0.0181 0.0179
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0527 0.1855
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1062 1
Echinococcus granulosus GPCR family 2 0.0016 0.0181 0.0179
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0019 0.0241 0.1091
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0019 0.0241 0.0466
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0551 0.2498
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Schistosoma mansoni protein kinase 0.0032 0.0553 0.198
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0551 0.519
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0144 0.0655
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0553 0.198
Trichomonas vaginalis sugar transport protein, putative 0.0014 0.0144 0.0655
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0019 0.0241 0.0466
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0553 0.2505
Schistosoma mansoni hypothetical protein 0.0016 0.0181 0.0179
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0553 0.0553
Leishmania major glucose transporter, lmgt3 0.0032 0.0551 0.3616
Loa Loa (eye worm) hypothetical protein 0.0035 0.0616 0.2791
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0343 0.3226
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0551 0.2498
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0262 0.0851
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0852 0.7707
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0019 0.0241 0.0098
Trypanosoma cruzi hexose transporter 0.0032 0.0551 0.519
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0553 0.0553
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0181 0.0179
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0527 0.1855
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Loa Loa (eye worm) hypothetical protein 0.0031 0.0527 0.2388
Echinococcus granulosus General substrate transporter 0.0088 0.1869 0.8364
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.1062 0.161
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.1062 0.4451
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0553 0.198
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.1062 0.6968
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0343 0.1923
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1062 0.4814
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0019 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0025 0.0392 0.1777
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0144 0.0655
Onchocerca volvulus DNA polymerase homolog 0.0019 0.0241 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Toxoplasma gondii sugar transporter ST3 0.0014 0.0144 0.0219
Entamoeba histolytica hypothetical protein 0.0023 0.0343 0.4023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0553 0.198
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0181 0.0179
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0181 0.0179
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.1062 0.6968
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0181 0.0179
Trypanosoma brucei glucose transporter, putative 0.0032 0.0551 0.4432
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0551 0.2498
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0144 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1524 1
Plasmodium vivax DNA polymerase alpha, putative 0.0019 0.0241 0.0098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0019 0.0241 1
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0343 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0553 0.198
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.1062 0.4451
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0181 0.0179
Giardia lamblia Hexose transporter 0.0014 0.0144 0.136
Leishmania major myo-inositol/proton symporter (MIT) 0.0014 0.0144 0.0948
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0241 0.1579
Trypanosoma brucei glucose transporter, putative 0.0032 0.0551 0.4432
Schistosoma mansoni inositol monophosphatase 0.0045 0.0852 0.343
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0019 0.0241 0.0466
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0893 0.3628
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0019 0.0241 0.0466
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.001 0.0048 0.0217
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1524 0.6692
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0343 0.1553
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0019 0.0241 0.1048
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0553 0.0553
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2206 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0852 0.343
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.0061 0.5
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0646 0.4239
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0742 0.4332
Schistosoma mansoni hypothetical protein 0.0035 0.0616 0.2286
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0551 0.2498
Trypanosoma brucei glucose transporter, putative 0.0032 0.0551 0.4432
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1524 0.2311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0893 0.3628
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0852 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0553 0.198
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0553 0.198
Trichomonas vaginalis glucose transporter, putative 0.0014 0.0144 0.0655
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0496 0.1707
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0019 0.0241 0.2265
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0014 0.0144 0.0568
Trypanosoma brucei glucose transporter 2A 0.0032 0.0551 0.4432
Trypanosoma brucei protein kinase, putative 0.0054 0.1062 1
Schistosoma mansoni glucose transport protein 0.0102 0.2206 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0181 0.0179
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2206 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Plasmodium falciparum hexose transporter 0.0102 0.2206 0.2206
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Loa Loa (eye worm) hypothetical protein 0.0032 0.0553 0.2505
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.1062 0.4814
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0553 0.0415
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0144 0.0655
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0551 0.2498
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0551 0.2498
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0241 0.2265
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0343 0.0961
Giardia lamblia Sugar-proton symporter 0.0014 0.0144 0.136
Leishmania major hypothetical protein, conserved 0.0014 0.0144 0.0948
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0553 0.0553
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0102 0.2206 1
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0343 0.0961
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0893 0.4046
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0019 0.0241 0.0098
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0551 0.519
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0616 0.2286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0893 0.3628
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0553 0.0839
Schistosoma mansoni hypothetical protein 0.0016 0.0181 0.0179
Schistosoma mansoni hypothetical protein 0.0102 0.2206 1
Loa Loa (eye worm) inositol-1 0.0045 0.0852 0.386
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0893 0.3628
Loa Loa (eye worm) major facilitator superfamily transporter 0.0014 0.0144 0.0655
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0553 0.0415
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0019 0.0241 0.0466
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0852 0.1291
Entamoeba histolytica protein kinase, putative 0.0032 0.0553 0.649
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0019 0.0241 0.1048
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0019 0.0241 0.2265
Brugia malayi Cam kinase protein 1 0.0032 0.0553 0.198
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0103 0.0465
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0181 0.0822
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.1062 0.4451
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0343 0.1681
Schistosoma mansoni hypothetical protein 0.0016 0.0181 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0144 0.0655
Plasmodium vivax hexose transporter 0.0102 0.2206 0.2092
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2206 1
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0893 0.3628
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.1062 1
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0019 0.0241 0.1091
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0144 0.0655
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0019 0.0241 0.1091
Trichomonas vaginalis sugar transporter, putative 0.0014 0.0144 0.0655
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.1062 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1062 0.4814
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.1062 0.4814
Plasmodium falciparum protein kinase 7 0.029 0.6596 0.6596
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0102 0.2206 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0181 0.0822
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0553 0.2505
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0102 0.2206 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0893 0.3628
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0343 0.216
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Loa Loa (eye worm) hypothetical protein 0.0014 0.0144 0.0655
Toxoplasma gondii sugar transporter ST2 0.0014 0.0144 0.0219
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0019 0.0241 0.2825
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1524 0.6692
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0553 0.198

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 28.2 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463190, AID463194, AID504542, AID504544] ChEMBL. No reference
Potency (functional) = 0.8913 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.9185 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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