Detailed information for compound 1304686

Basic information

Technical information
  • TDR Targets ID: 1304686
  • Name: 6-ethyl-3-(2-methylpropyl)thieno[3,2-e]pyrimi din-4-one
  • MW: 236.333 | Formula: C12H16N2OS
  • H donors: 0 H acceptors: 1 LogP: 3.07 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1sc2c(c1)c(=O)n(cn2)CC(C)C
  • InChi: 1S/C12H16N2OS/c1-4-9-5-10-11(16-9)13-7-14(12(10)15)6-8(2)3/h5,7-8H,4,6H2,1-3H3
  • InChiKey: WPBKKNCTLRFOAM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-ethyl-3-isobutyl-thieno[3,2-e]pyrimidin-4-one
  • 6-ethyl-3-isobutyl-4-thieno[3,2-e]pyrimidinone
  • SMR000230038
  • ZINC00148855
  • 6-ethyl-3-isobutylthieno[2,3-d]pyrimidin-4(3H)-one
  • MLS000706583

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Brugia malayi hypothetical protein 0.0014 0.0012 0.0025
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0026 1
Schistosoma mansoni cpg binding protein 0.0089 0.019 0.0386
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0012
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0029 0.006
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0008 0.0273
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0029 0.0029
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0029 0.006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0034 0.007
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0072 0.7476
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0032 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0217 1
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0217 0.3943
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.011 0.0223
Brugia malayi map kinase activated protein kinase protein 2 0.2098 0.4915 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0018 0.0037
Echinococcus multilocularis protein dispatched 1 0.0058 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0029 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0029 0.006
Plasmodium falciparum importin beta, putative 0.003 0.005 0.5038
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0012 0.0025
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0029 0.006
Echinococcus granulosus importin subunit beta 1 0.003 0.005 0.0101
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0015
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0026 0.0052
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0026 0.0437
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0029 0.006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0037 0.0637
Schistosoma mansoni hypothetical protein 0.0319 0.0729 0.1484
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.011 0.0223
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0049 0.0095 1
Plasmodium vivax ubiquitin activating enzyme, putative 0.0049 0.0095 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0029 0.006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0055 0.0113
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0003 0.0006
Brugia malayi nuclear receptor NHR-67 0.001 0.0003 0.0006
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0064
Schistosoma mansoni importin beta-1 0.003 0.005 0.0101
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0259 0.0259
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0026 0.111
Echinococcus multilocularis GPCR, family 2 0.0016 0.0018 0.0018
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0259 1
Giardia lamblia Ubiquitin-activating enzyme E1 1 0.0015 0.0015 0.0376
Echinococcus multilocularis protein patched 0.0051 0.01 0.01
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0286 0.0651 0.1325
Giardia lamblia DINP protein human, muc B family 0.002 0.0026 0.086
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0031 0.0031
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0056 0.2506
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0008 0.0273
Brugia malayi isocitrate dehydrogenase 0.0032 0.0056 0.0113
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0049 0.0095 0.0192
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0467
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0032 0.0055 0.0112
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0379 0.0772
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.01 0.01
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0259 0.0528
Loa Loa (eye worm) hypothetical protein 0.0062 0.0127 0.0258
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0018
Trichomonas vaginalis set domain proteins, putative 0.0242 0.0549 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0055 0.1254
Leishmania major importin beta-1 subunit, putative 0.0024 0.0037 0.0569
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0029 0.006
Onchocerca volvulus 0.0012 0.0008 0.0083
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.1372
Brugia malayi ThiF family protein 0.0049 0.0095 0.0192
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0029 0.0029
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0005 0.0064
Echinococcus granulosus Protein patched homolog 1 0.0051 0.01 0.0203
Onchocerca volvulus 0.0089 0.019 0.3421
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0029 0.006
Schistosoma mansoni hypothetical protein 0.0058 0.0117 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0029 0.006
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0026 0.0052
Onchocerca volvulus 0.0014 0.0012 0.017
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0029 0.006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0029 0.006
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.0217 0.0443
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0008 0.0015
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0056 0.5539
Trypanosoma brucei unspecified product 0.0013 0.0011 0.0448
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.0217 0.0443
Schistosoma mansoni hypothetical protein 0.0352 0.0807 0.1643
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0056 0.1263
Schistosoma mansoni patched 1 0.0051 0.01 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.0108
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Echinococcus granulosus dna polymerase eta 0.002 0.0026 0.0052
Entamoeba histolytica ubiquitin-activating enzyme, putative 0.0015 0.0015 0.0434
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0031 0.0064
Trypanosoma brucei ubiquitin-conjugating enzyme E2, putative 0.0025 0.0039 0.1741
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0026 0.0052
Brugia malayi ecdysteroid receptor 0.0021 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0025
Trypanosoma brucei unspecified product 0.0013 0.0011 0.0448
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0006
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0467
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0012
Brugia malayi Trypsin family protein 0.0014 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0003 0.0006
Echinococcus multilocularis Mastin 0.0014 0.0012 0.0012
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0026 0.111
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0037
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0008 0.0108
Echinococcus granulosus dnaJ subfamily B 0.1273 0.2973 0.605
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0029 0.006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0056 0.0056
Trichomonas vaginalis helicase, putative 0.002 0.0027 0.0467
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0008 0.0008
Echinococcus multilocularis enteropeptidase 0.0014 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0018 0.0037
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.1129
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0012
Echinococcus granulosus snurportin 1 0.0319 0.0729 0.1484
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.0108
Brugia malayi topoisomerase 0.0012 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0379 0.0379
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.006
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0025 0.0039 0.1741
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0467
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0003 0.0003
Brugia malayi MH2 domain containing protein 0.0121 0.0264 0.0538
Loa Loa (eye worm) DR-78 0.001 0.0003 0.0006
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.0217 0.3927
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0008 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.0217 0.0443
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0055 0.0113
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.01 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0003 0.0006
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0117 0.0237
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0015
Brugia malayi Trypsin family protein 0.0014 0.0012 0.0025
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0006 0.0012
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0026 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0029 0.006
Schistosoma mansoni zinc finger protein 0.001 0.0003 0.0006
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.2098 0.4915 0.4915
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0029 0.006
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0037 0.1616
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.008 0.1434
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0029 0.006
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0037
Schistosoma mansoni myst-related protein 0.0011 0.0004 0.0009
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0012 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0467
Echinococcus multilocularis snurportin 1 0.0319 0.0729 0.0729
Schistosoma mansoni nuclear receptor 0.001 0.0003 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0264 0.0538
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0056 0.0056
Echinococcus granulosus glycoprotein Antigen 5 0.0014 0.0012 0.0025
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0003 0.0006
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.006
Onchocerca volvulus 0.0242 0.0549 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.005 0.2231
Loa Loa (eye worm) hypothetical protein 0.003 0.005 0.0101
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0049 0.0095 0.0192
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0003 0.0003
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Echinococcus multilocularis dna polymerase kappa 0.002 0.0026 0.0026
Schistosoma mansoni ran 0.0022 0.0031 0.0064
Trypanosoma brucei unspecified product 0.002 0.0026 0.111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0029 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0008 0.0273
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0029 0.0029
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.008 0.1434
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0056 0.0056
Brugia malayi Pre-SET motif family protein 0.0213 0.048 0.0978
Echinococcus granulosus enteropeptidase 0.0014 0.0012 0.0025
Brugia malayi hypothetical protein 0.001 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0025
Echinococcus granulosus MAP kinase activated protein kinase 2 0.2098 0.4915 1
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0003 0.0003
Brugia malayi Importin beta-1 subunit 0.003 0.005 0.0101
Loa Loa (eye worm) ThiF family protein 0.0032 0.0055 0.0112
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0003 0.0006
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.0217 1
Brugia malayi steroid hormone receptor 0.0021 0.0029 0.006
Onchocerca volvulus 0.0014 0.0012 0.017
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0056 0.157
Brugia malayi ube2i2 protein 0.0025 0.0039 0.008
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0012 0.0008 0.5
Schistosoma mansoni DNA polymerase eta 0.002 0.0026 0.0052
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0006
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0034 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0029 0.006
Brugia malayi Pre-SET motif family protein 0.0032 0.0055 0.0113
Schistosoma mansoni coup transcription factor 0.0021 0.0029 0.006
Echinococcus multilocularis nibrin 0.0012 0.0008 0.0008
Echinococcus multilocularis dnaJ subfamily B 0.1273 0.2973 0.2973
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0072 0.306
Brugia malayi hypothetical protein 0.0012 0.0008 0.0015
Schistosoma mansoni topbp1 0.0012 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0029 0.0029
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Brugia malayi CXXC zinc finger family protein 0.0089 0.019 0.0386
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0012 0.0025
Echinococcus granulosus GPCR family 2 0.0016 0.0018 0.0037
Entamoeba histolytica Ran family GTPase 0.0022 0.0031 0.1054
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0055 0.2482
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0008 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0029 0.006
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0026 0.111
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.0108
Chlamydia trachomatis DNA ligase 0.0012 0.0008 0.5
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0029 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0029 0.006
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0031 0.1372
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0025
Echinococcus granulosus Mastin 0.0014 0.0012 0.0025
Toxoplasma gondii hypothetical protein 0.0049 0.0095 0.2281
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0322 0.0654
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.011 0.0223
Trypanosoma brucei polo-like protein kinase 0.0101 0.0217 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0026 0.0026
Leishmania major GTP-binding protein, putative 0.0022 0.0031 0.0295
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0027 0.0467
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0046 0.0095
Echinococcus multilocularis expressed conserved protein 0.0112 0.0242 0.0242
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.0217 1
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0032 0.0055 0.0112
Loa Loa (eye worm) ube2i2 protein 0.0025 0.0039 0.008
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0008 0.0108
Loa Loa (eye worm) hypothetical protein 0.0016 0.0018 0.0037
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0026 0.111
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0006
Brugia malayi nuclear receptor RXR 0.001 0.0003 0.0006
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0026 0.0052
Trichomonas vaginalis ran, putative 0.0022 0.0031 0.0541
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0025 0.0039 0.1741
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0008 0.0108
Brugia malayi hypothetical protein 0.0011 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0025
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0003 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0101 0.0206
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0012 0.0012
Brugia malayi hypothetical protein 0.001 0.0003 0.0006
Loa Loa (eye worm) acetyltransferase 0.0145 0.0322 0.0654
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0026 0.0052
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0029 0.006
Plasmodium falciparum SUMO-conjugating enzyme UBC9 0.0025 0.0039 0.3865
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0008 0.0273
Schistosoma mansoni hypothetical protein 0.0049 0.0095 0.0194
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0029 0.0029
Schistosoma mansoni hypothetical protein 0.0049 0.0095 0.0194
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0008 0.0108
Echinococcus granulosus geminin 0.0352 0.0807 0.1643
Schistosoma mansoni hypothetical protein 0.0016 0.0018 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0029 0.006
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0018 0.0037
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0029 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.011 0.011
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0217 0.3943
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0011 0.0006 0.0212
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0047 0.0096
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0467
Brugia malayi DKFZp564C0469 protein 0.0012 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.006
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.01 0.0203
Brugia malayi Trypsin-like protease protein 5 0.0014 0.0012 0.0025
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0127
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0049 0.0095 0.0095
Onchocerca volvulus 0.0021 0.0029 0.0481
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0012 0.0025
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0025 0.0039 0.1367
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0029 0.0481
Trichomonas vaginalis hypothetical protein 0.0011 0.0005 0.0064
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0322 0.0322
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0259 0.0528
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.0217 0.0443
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0037 0.0637
Brugia malayi CHE-14 protein 0.0051 0.01 0.0203
Brugia malayi Nuclear hormone receptor E75 0.001 0.0003 0.0006
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0029 0.006
Schistosoma mansoni hypothetical protein 0.0049 0.0095 0.0194
Loa Loa (eye worm) hypothetical protein 0.0052 0.0101 0.0206
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0056 0.2506
Onchocerca volvulus 0.0014 0.0012 0.017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0025
Echinococcus granulosus ubiquitin conjugating enzyme e2 i 0.0025 0.0039 0.008
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.1273 0.2973 0.605
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0217 0.3943
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0056 0.2506
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0003 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0011 0.0448
Brugia malayi Trypsin family protein 0.0014 0.0012 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0026 0.111
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0467
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0104 0.1865
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0003 0.0003
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0026 0.111
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0467
Echinococcus multilocularis cpg binding protein 0.0094 0.0202 0.0202
Trypanosoma cruzi ubiquitin-activating enzyme-like protein 0.0015 0.0015 0.0639
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0029 0.006
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0119 0.0259 0.0528
Schistosoma mansoni hypothetical protein 0.0014 0.0012 0.0025
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0034 0.007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0029 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.01 0.179
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.0108
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0012
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Echinococcus multilocularis transmembrane protease serine 3 0.0014 0.0012 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0012 0.0025
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0032 0.0055 0.548
Schistosoma mansoni myst-related protein 0.0011 0.0004 0.0009
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.0217 0.8359
Brugia malayi ThiF family protein 0.0032 0.0055 0.0112
Echinococcus multilocularis importin subunit beta 1 0.003 0.005 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0029 0.006
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.2098 0.4915 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0056 0.5696
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0029 0.006
Mycobacterium ulcerans hypothetical protein 0.0014 0.0012 0.2631
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0029 0.006
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0029 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0026 0.111
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0029 0.0481
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0056 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0026 0.0437
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0014 0.0012 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0026 0.111
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0008 0.0015
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0012 0.0025
Schistosoma mansoni DNA ligase IV 0.0012 0.0008 0.0015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0095 0.0192
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0034 0.0034
Onchocerca volvulus 0.0014 0.0012 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Brugia malayi conserved hypotetical protein 0.001 0.0003 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0029 0.006
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0056 0.1263
Echinococcus granulosus nibrin 0.0012 0.0008 0.0015
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0025 0.0039 0.0831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.011 0.0223
Echinococcus multilocularis ubiquitin conjugating enzyme e2 i 0.0025 0.0039 0.0039
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0048 0.0098
Echinococcus granulosus cpg binding protein 0.0094 0.0202 0.0411
Entamoeba histolytica hypothetical protein 0.0012 0.0008 0.0124
Loa Loa (eye worm) hypothetical protein 0.0051 0.01 0.0203
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0029 0.006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0012
Schistosoma mansoni hypothetical protein 0.0352 0.0807 0.1643
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0467
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0029 0.006
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.005 0.2231
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0072 0.2644
Leishmania major ubiquitin-activating enzyme-like protein 0.0032 0.0055 0.1544
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.008 0.1904
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0026 0.0052
Entamoeba histolytica hypothetical protein 0.0024 0.0037 0.1261
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0026 0.0832
Brugia malayi Trypsin family protein 0.0014 0.0012 0.0025
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0467
Echinococcus granulosus transmembrane protease serine 3 0.0014 0.0012 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.011 0.011
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0031 0.2726
Brugia malayi hypothetical protein 0.0286 0.0651 0.1325
Brugia malayi hypothetical protein 0.0011 0.0006 0.0012
Toxoplasma gondii ThiF family protein 0.0032 0.0055 0.125
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0018 0.0018
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0319 0.0729 0.1484
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0032 0.0055 0.5639
Onchocerca volvulus 0.0032 0.0055 0.0958
Brugia malayi tailless protein 0.001 0.0003 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0467
Trichomonas vaginalis CAMK family protein kinase 0.0053 0.0104 0.1865
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0052
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0014 0.0012 0.0025
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0008 0.0015
Plasmodium vivax importin-beta 2, putative 0.003 0.005 0.4857
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0467
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.0651 0.1325
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0031 0.0622
Brugia malayi nuclear receptor NHR-88 0.0021 0.0029 0.006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0014 0.0012 0.0025
Schistosoma mansoni hypothetical protein 0.0035 0.0063 0.0127
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0008 0.0108
Onchocerca volvulus 0.0014 0.0012 0.017
Plasmodium vivax SET domain protein, putative 0.0032 0.0055 0.5496
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0217 0.3943
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0006
Schistosoma mansoni cpg binding protein 0.0094 0.0202 0.0411
Brugia malayi nuclear receptor RXR 0.0011 0.0006 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.0428 0.0871
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0217 0.3943
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0003 0.0006
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0056 0.0113
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0217 0.3943
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.008 0.1904
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.011 0.0223
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.011 0.0223
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0055 0.0113
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.0064
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0029 0.0029
Brugia malayi Nuclear hormone receptor E75 0.001 0.0003 0.0006
Trichomonas vaginalis ubiquitin-conjugating enzyme rad6, putative 0.0025 0.0039 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0029 0.006
Schistosoma mansoni nuclear receptor 0.001 0.0003 0.0006
Giardia lamblia UBC3 0.0025 0.0039 0.1509
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.0651 0.0651
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0003 0.0006
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0056 0.0113
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0029 0.006
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0029 0.0481
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.0217 0.3943
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0055 0.0055
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0032 0.0055 0.2482
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0063 0.0127
Brugia malayi nuclear hormone receptor 0.001 0.0003 0.0006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0056 0.0113
Onchocerca volvulus 0.0058 0.0117 0.208
Echinococcus granulosus expressed conserved protein 0.0112 0.0242 0.0493
Brugia malayi nuclear hormone receptor 0.0021 0.0029 0.006
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.011 0.0223
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0025 0.0039 0.071
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0003 0.0006
Brugia malayi hypothetical protein 0.0012 0.0008 0.0015
Giardia lamblia Kinase, PLK 0.0101 0.0217 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0029 0.006
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0056 0.0113
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0264 0.0538
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0029 0.006
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.0217 0.0217
Schistosoma mansoni topbp1 0.0012 0.0008 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0029 0.006
Schistosoma mansoni hypothetical protein 0.0014 0.0012 0.0025
Trichomonas vaginalis molybdopterin biosynthesis moeb protein, putative 0.0015 0.0015 0.0252
Schistosoma mansoni serine/threonine protein kinase 0.2098 0.4915 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0026 0.111
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0014 0.0012 0.0025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0101 0.0206
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0018 0.0037
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0026 0.111
Echinococcus multilocularis glycoprotein Antigen 5 0.0014 0.0012 0.0012
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0008 0.0124
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0044 0.0084 0.0171
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0029 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0003
Echinococcus multilocularis dna polymerase eta 0.002 0.0026 0.0026
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0055 0.0113
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0003 0.0006
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0003 0.0006
Brugia malayi ecdysone receptor 0.001 0.0003 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0011 0.0448
Plasmodium falciparum replication factor C subunit 1, putative 0.0012 0.0008 0.0352
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.008 0.8347
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0031 0.2982
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.008 0.0163
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0029 0.006
Schistosoma mansoni survival motor neuron protein 0.0058 0.0117 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0467
Echinococcus granulosus dna polymerase kappa 0.002 0.0026 0.0052
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0055 0.0055
Schistosoma mansoni kinase 0.0054 0.0107 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0467
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0028 0.0045 0.1993
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.048 0.0978
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0467
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.005 0.1108
Schistosoma mansoni cercarial elastase (S01 family) 0.0014 0.0012 0.0025
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0008 0.0015
Schistosoma mansoni hypothetical protein 0.0049 0.0095 0.0194
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0003 0.0006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0047 0.0047
Brugia malayi RNA, U transporter 1 0.0085 0.0179 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0467
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0029 0.006
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.019 0.0386
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0006
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0003 0.0006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0101 0.0206
Echinococcus multilocularis geminin 0.0352 0.0807 0.0807
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0008 0.0108
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0011 0.0448
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0312 0.0635
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0264 0.0536
Plasmodium vivax SUMO-conjugating enzyme UBC9, putative 0.0025 0.0039 0.3641
Schistosoma mansoni ran 0.0022 0.0031 0.0064
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0047 0.0096
Brugia malayi nuclear receptor NHR-88 0.001 0.0003 0.0006
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0322 0.0654
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0029 0.006
Schistosoma mansoni ubiquitin-conjugating enzyme E2 I 0.0025 0.0039 0.008
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0012 0.0008 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0113
Toxoplasma gondii histone lysine methyltransferase SET1 0.0174 0.0389 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0055 0.0113
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0006 0.0012
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0056 0.2506
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0008 0.00000901
Loa Loa (eye worm) trypsin family protein 0.0014 0.0012 0.0025
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0037 0.0637
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0027 0.0467
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.006
Treponema pallidum DNA ligase (lig) 0.0012 0.0008 0.5
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0025 0.0039 0.1367
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0005 0.0064
Schistosoma mansoni cpg binding protein 0.0094 0.0202 0.0411
Onchocerca volvulus 0.0014 0.0012 0.017
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0014 0.0012 0.0012
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0029 0.006

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1458 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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