Detailed information for compound 1312703

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 328.367 | Formula: C20H16N4O
  • H donors: 1 H acceptors: 3 LogP: 3.26 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1=NN=C(Nc2c1cccc2)c1cccnc1
  • InChi: 1S/C20H16N4O/c1-25-16-10-8-14(9-11-16)19-17-6-2-3-7-18(17)22-20(24-23-19)15-5-4-12-21-13-15/h2-13H,1H3,(H,22,24)
  • InChiKey: NLNDJDOVBUZZHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0265 0.0386 0.1418
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0041 0.0028 0.0093
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0004 0.0017
Giardia lamblia Kinase, CMGC GSK 0.1423 0.2241 0.8285
Entamoeba histolytica hypothetical protein 0.0603 0.0927 0.4137
Entamoeba histolytica hypothetical protein 0.0072 0.0077 0.0342
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.002 0.0042
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1712 0.2703 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0012 0.0017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0115 0.0146 0.0531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0494 0.0753 0.1038
Loa Loa (eye worm) hypothetical protein 0.0258 0.0375 0.1674
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0149 0.02 0.0729
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0028 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0261 0.1082
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0071 0.0316
Entamoeba histolytica hypothetical protein 0.0079 0.0089 0.0397
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0124 0.016 0.07
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0068 0.0071 0.0172
Entamoeba histolytica protein kinase, putative 0.0068 0.0071 0.0316
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1712 0.2703 1
Brugia malayi intracellular kinase 0.1423 0.2241 0.3088
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0041 0.0028 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0028 0.0093
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0041 0.0028 0.0093
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0373 0.056 0.2044
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0071 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0385 0.1645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0028 0.0035
Entamoeba histolytica protein kinase, putative 0.0068 0.0071 0.0316
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0028 0.0125
Onchocerca volvulus 0.0026 0.0004 0.0004
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0041 0.0028 0.0108
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0061 0.0215
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0327 0.0486 0.1787
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0004 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0009 0.0022
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0012 0.0017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0327 0.0486 0.1787
Entamoeba histolytica hypothetical protein 0.0041 0.0028 0.0125
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0327 0.0486 0.1796
Brugia malayi intermediate filament protein 0.0026 0.0004 0.0005
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0068 0.0071 0.0316
Echinococcus multilocularis peregrin 0.0029 0.0009 0.0013
Plasmodium vivax glycogen synthase kinase 3, putative 0.1423 0.2241 0.8289
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0014 0.5007
Leishmania major hypothetical protein, conserved 0.0041 0.0028 0.0103
Brugia malayi PHD-finger family protein 0.0029 0.0009 0.0012
Toxoplasma gondii RNA-directed DNA polymerase 0.1712 0.2703 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.002 0.0073
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0115 0.0146 0.0636
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0061 0.0255
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0041 0.0028 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0071 0.03
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0327 0.0486 0.1787
Trichomonas vaginalis PIKK family atypical protein kinase 0.022 0.0314 0.1323
Loa Loa (eye worm) hypothetical protein 0.0086 0.0099 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.036 0.1531
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0068 0.0071 0.0316
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0041 0.0028 0.0108
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0028 0.0125
Trypanosoma cruzi target of rapamycin kinase 3 0.0265 0.0386 0.1418
Toxoplasma gondii target of rapamycin (TOR), putative 0.0249 0.036 0.1323
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0265 0.0386 0.1707
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0041 0.0028 0.0093
Brugia malayi hypothetical protein 0.0452 0.0685 0.0944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.0289 0.1209
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0041 0.0028 0.0062
Brugia malayi FAT domain containing protein 0.0045 0.0033 0.0046
Plasmodium falciparum telomerase reverse transcriptase 0.1712 0.2703 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.002 0.0073
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0115 0.0146 0.0531
Entamoeba histolytica protein kinase rad3, putative 0.0079 0.0089 0.0397
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0265 0.0386 0.1647
Schistosoma mansoni lozenge 0.0057 0.0052 0.0217
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.002 0.009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0017
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0115 0.0146 0.0531
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0327 0.0486 0.2153
Echinococcus multilocularis aurora kinase A 0.0068 0.0071 0.0172
Brugia malayi hypothetical protein 0.0026 0.0003 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.036 0.1531
Echinococcus granulosus microtubule associated protein 2 0.0698 0.1079 0.4804
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0028 0.0038
Leishmania major hypothetical protein, conserved 0.0026 0.0003 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0077 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0385 0.1645
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0019 0.0067
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0079 0.0089 0.0219
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0121 0.0167
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0052 0.8633
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0115 0.0146 0.0636
Plasmodium vivax hypothetical protein 0.0041 0.0028 0.0093
Leishmania major phosphatidylinositol kinase, putative 0.0041 0.0028 0.0103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0054
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0041 0.0028 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0486 0.2095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.016 0.0632
Giardia lamblia Aurora kinase 0.0068 0.0071 0.023
Loa Loa (eye worm) inositol-1 0.0037 0.002 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0089 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0486 0.2095
Onchocerca volvulus 0.0041 0.0028 0.0028
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0061 0.0255
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0753 0.1167 0.4311
Leishmania major phosphatidylinositol 3-kinase, putative 0.0115 0.0146 0.054
Loa Loa (eye worm) hypothetical protein 0.0062 0.0061 0.0274
Loa Loa (eye worm) hypothetical protein 0.0045 0.0033 0.0148
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0265 0.0386 0.1418
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0012 0.0037
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.1423 0.2241 0.8289
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.0328 0.1465
Trypanosoma brucei aurora B kinase 0.0068 0.0071 0.0252
Onchocerca volvulus 0.1423 0.2241 0.2241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0385 0.1645
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0077 0.0326
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0061 0.0255
Schistosoma mansoni hypothetical protein 0.0041 0.0028 0.0108
Giardia lamblia GTOR 0.0327 0.0486 0.1769
Schistosoma mansoni hypothetical protein 0.0072 0.0077 0.0326
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0523 0.0799 0.3508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0202 0.0286 0.1196
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0265 0.0386 0.1647
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0041 0.0028 0.0093
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0009 0.0039
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0115 0.0146 0.054
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0028 0.0125
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0009 0.0022
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0009 0.0022
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0523 0.0799 0.3508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.016 0.0632
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0071 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0155 0.0691
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0121 0.0167
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0753 0.1167 0.5163
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0045 0.0033 0.0131
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0037
Brugia malayi Telomerase reverse transcriptase 0.4556 0.7258 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0028 0.0125
Echinococcus granulosus glycogen synthase kinase 3 beta 0.1423 0.2241 1
Schistosoma mansoni protein kinase 0.0068 0.0071 0.03
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0068 0.0071 0.0316
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0068 0.0071 0.03
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0012 0.0054
Plasmodium falciparum phd finger protein, putative 0.0029 0.0009 0.0022
Plasmodium falciparum serine/threonine protein kinase, putative 0.0068 0.0071 0.0252
Onchocerca volvulus 0.0026 0.0004 0.0004
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0327 0.0486 0.1796
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0327 0.0486 0.2166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.0289 0.1209
Loa Loa (eye worm) hypothetical protein 0.0038 0.0023 0.0101
Onchocerca volvulus Alhambra homolog 0.0029 0.0009 0.0009
Echinococcus multilocularis 0.0041 0.0028 0.0062
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.1079 0.4804
Echinococcus granulosus serine protein kinase ATM 0.0079 0.0089 0.038
Loa Loa (eye worm) hypothetical protein 0.0125 0.0162 0.0721
Echinococcus granulosus protein kinase shaggy 0.1423 0.2241 1
Brugia malayi serine/threonine kinase 12 0.0068 0.0071 0.0098
Loa Loa (eye worm) hypothetical protein 0.0051 0.0043 0.019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0089 0.031
Schistosoma mansoni hypothetical protein 0.0045 0.0033 0.0131
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0027 0.0105
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0115 0.0146 0.0365
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0052 0.0125
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0077 0.0326
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0041 0.0028 0.0093
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0084 0.036
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.1423 0.2241 0.8289
Leishmania major phosphatidylinositol kinase related protein, putative 0.0041 0.0028 0.0103
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0052 0.0218
Giardia lamblia Hypothetical protein 0.0041 0.0028 0.0071
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0019 0.0084
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0124 0.016 0.0402
Giardia lamblia Phosphatidylinositol 4-kinase 0.0041 0.0028 0.0071
Leishmania major protein kinase, putative 0.0068 0.0071 0.0262
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0327 0.0486 0.1237
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0327 0.0486 0.2153
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0071 0.0316
Onchocerca volvulus Huntingtin homolog 0.0125 0.0162 0.0162
Brugia malayi serine/threonine protein kinase 6 0.0068 0.0071 0.0098
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0265 0.0386 0.1427
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1423 0.2241 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0124 0.016 0.0584
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0052 0.0194
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0116 0.0502
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0753 0.1167 0.5163
Entamoeba histolytica hypothetical protein 0.0072 0.0077 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0104 0.0128 0.0484
Entamoeba histolytica hypothetical protein 0.0041 0.0028 0.0125
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.002 0.0064
Plasmodium falciparum glycogen synthase kinase 3 0.1423 0.2241 0.8289
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0753 0.1167 0.5207
Onchocerca volvulus Huntingtin homolog 0.0125 0.0162 0.0162
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0041 0.0028 0.0125
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0115 0.0146 0.0652
Loa Loa (eye worm) hypothetical protein 0.0494 0.0753 0.3362
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0265 0.0386 0.1647
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0061 0.0146
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0115 0.0146 0.0567
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.036 0.1531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0079 0.0089 0.0122
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0124 0.016 0.0221
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0265 0.0386 0.1722
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0061 0.0225
Entamoeba histolytica protein kinase domain containing protein 0.1423 0.2241 1
Leishmania major phosphatidylinositol 4-kinase, putative 0.0041 0.0028 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0033 0.0059
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0028 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.002 0.3309
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0115 0.0146 0.0531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0079 0.0089 0.0122
Echinococcus multilocularis serine protein kinase ATM 0.0079 0.0089 0.0219
Trichomonas vaginalis PIKK family atypical protein kinase 0.0186 0.026 0.108
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0068 0.0071 0.0252
Echinococcus granulosus peregrin 0.0029 0.0009 0.0022
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0041 0.0028 0.0093
Brugia malayi serine/threonine-protein kinase 6 0.0068 0.0071 0.0098
Loa Loa (eye worm) hypothetical protein 0.01 0.0121 0.054
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0753 0.1167 0.5199
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0071 0.0097
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.1423 0.2241 1
Toxoplasma gondii aurora kinase 0.0068 0.0071 0.0252
Leishmania major hypothetical protein, unknown function 0.0041 0.0028 0.0103
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0086 0.0099 0.0358
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0166 0.0228 0.0833
Loa Loa (eye worm) runx1 0.0057 0.0052 0.0234
Trypanosoma brucei telomerase reverse transcriptase 0.1712 0.2703 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0046 0.0207
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0121 0.054
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0052 0.8633
Trichomonas vaginalis CMGC family protein kinase 0.1423 0.2241 1
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0115 0.0146 0.0652
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2458 0.3898 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0041 0.0028 0.0108
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0115 0.0146 0.0531
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0012 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.016 0.0632
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0345 0.0514 0.2292
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0115 0.0146 0.0652
Schistosoma mansoni hypothetical protein 0.0068 0.0071 0.0298
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0124 0.016 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.016 0.0632
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0115 0.0146 0.0636
Giardia lamblia Telomerase catalytic subunit 0.1712 0.2703 1
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0041 0.0028 0.0093
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.002 0.0064
Loa Loa (eye worm) hypothetical protein 0.0026 0.0003 0.0012
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0009 0.0022
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0079 0.0089 0.0319
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0009 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0202 0.0286 0.1196
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0753 0.1167 0.2987
Entamoeba histolytica protein kinase, putative 0.1423 0.2241 1
Brugia malayi follicle stimulating hormone receptor 0.0229 0.0328 0.0453
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0711 0.1101 0.4911
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0041 0.0028 0.0108
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0009 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0261 0.1082
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0115 0.0146 0.0567
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0124 0.016 0.0584
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0079 0.0089 0.0319
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0115 0.0146 0.0636
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0494 0.0753 0.335
Leishmania major phosphatidylinositol 3-kinase, putative 0.0124 0.016 0.0593
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0494 0.0753 0.1925
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0019 0.0038
Schistosoma mansoni fkbp-rapamycin associated protein 0.0079 0.0089 0.038
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0753 0.1167 0.5163
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0124 0.016 0.0584
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0041 0.0028 0.0108
Loa Loa (eye worm) AUR protein kinase 0.0068 0.0071 0.0316
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0041 0.0028 0.0093
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0041 0.0028 0.0062
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0037
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0023 0.0011
Loa Loa (eye worm) hypothetical protein 0.0452 0.0685 0.3056
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0116 0.0289
Schistosoma mansoni hypothetical protein 0.0029 0.0009 0.0022
Loa Loa (eye worm) phosphatidylinositol 3 0.0124 0.016 0.0716
Loa Loa (eye worm) hypothetical protein 0.0452 0.0685 0.3056
Loa Loa (eye worm) hypothetical protein 0.0079 0.0089 0.0397
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0079 0.0089 0.038
Brugia malayi jmjC domain containing protein 0.0036 0.0019 0.0026
Brugia malayi hypothetical protein 0.0072 0.0077 0.0106
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0079 0.0089 0.0319
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0115 0.0146 0.0567
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0079 0.0089 0.038
Echinococcus multilocularis Protein lozenge 0.0057 0.0052 0.0125
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0052 0.0072
Loa Loa (eye worm) hypothetical protein 0.0068 0.0071 0.0315
Loa Loa (eye worm) CMGC/GSK protein kinase 0.1423 0.2241 1
Entamoeba histolytica hypothetical protein 0.0041 0.0028 0.0125
Loa Loa (eye worm) phosphatidylinositol kinase 0.0041 0.0028 0.0125
Schistosoma mansoni inositol monophosphatase 0.0037 0.002 0.0073
Echinococcus multilocularis GPCR, family 2 0.0031 0.0012 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0261 0.1082
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0027 0.006
Echinococcus multilocularis Zinc finger, PHD finger 0.0115 0.0146 0.0365
Entamoeba histolytica protein kinase , putative 0.0068 0.0071 0.0316
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0041 0.0028 0.0093
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0038 0.0023 0.0073
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0037
Loa Loa (eye worm) hypothetical protein 0.0125 0.0162 0.0721
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0071 0.0229
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0004 0.0017
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0191 0.0268 0.0961
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0753 0.1167 0.5199
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.1079 0.276
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0115 0.0146 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0187 0.0261 0.1082
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.002 0.0074
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0012 0.0021
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0052 0.0218
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0265 0.0386 0.1722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0385 0.1645
Brugia malayi jmjC domain containing protein 0.0097 0.0116 0.016
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0041 0.0028 0.0093
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0041 0.0028 0.0062
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0019 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0061 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0028 0.4595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0204 0.0289 0.1209
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0115 0.0146 0.0531
Loa Loa (eye worm) phosphatidylinositol 3 0.0327 0.0486 0.2166
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0041 0.0028 0.0093
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0012 0.0021
Entamoeba histolytica hypothetical protein 0.0072 0.0077 0.0342
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.002 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.036 0.1531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0041 0.0028 0.0038
Entamoeba histolytica protein kinase domain containing protein 0.1423 0.2241 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0019 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0023 0.0011
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0041 0.0028 0.0093
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.1423 0.2241 0.5745
Entamoeba histolytica hypothetical protein 0.0072 0.0077 0.0342
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0155 0.0691
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0061 1
Echinococcus multilocularis protein kinase shaggy 0.1423 0.2241 0.5745
Brugia malayi Bromodomain containing protein 0.0029 0.0009 0.0012
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.002 0.5
Trichomonas vaginalis CMGC family protein kinase 0.1423 0.2241 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.0486 0.2095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0089 0.031
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0223 0.032 0.1173
Brugia malayi Inositol-1 0.0037 0.002 0.0028
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0124 0.016 0.0584
Trypanosoma brucei protein kinase, putative 0.1423 0.2241 0.8289
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.1423 0.2241 0.8291
Trypanosoma cruzi aurora B kinase, putative 0.0068 0.0071 0.0252
Loa Loa (eye worm) phosphatidylinositol 3 0.0041 0.0028 0.0125
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0327 0.0486 0.2166
Echinococcus granulosus GPCR family 2 0.0031 0.0012 0.0037
Onchocerca volvulus 0.0452 0.0685 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0028 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0124 0.016 0.0632
Giardia lamblia Kinase, CMGC GSK 0.1423 0.2241 0.8285
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0014 0.2301
Loa Loa (eye worm) hypothetical protein 0.0029 0.0009 0.0039
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0041 0.0028 0.0108
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0061 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.036 0.1531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.036 0.1531
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0041 0.0028 0.0093
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0265 0.0386 0.0532
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0265 0.0386 0.1418
Leishmania major telomerase reverse transcriptase, putative 0.1712 0.2703 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.036 0.1531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0265 0.0385 0.1645
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0052 0.8633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0186 0.026 0.108
Echinococcus granulosus aurora kinase A 0.0068 0.0071 0.03
Trichomonas vaginalis PIKK family atypical protein kinase 0.0186 0.026 0.108
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0061 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0059 0.0264
Loa Loa (eye worm) phosphatidylinositol 3 0.0603 0.0927 0.4137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0282 0.0414 0.1773
Loa Loa (eye worm) phosphatidylinositol 3 0.0223 0.032 0.1426
Plasmodium vivax telomerase reverse transcriptase, putative 0.1712 0.2703 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0753 0.1167 0.1608
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0327 0.0486 0.1787
Onchocerca volvulus 0.0041 0.0028 0.0028
Toxoplasma gondii FATC domain-containing protein 0.0079 0.0089 0.0319
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0045 0.0033 0.0075
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0037
Brugia malayi hypothetical protein 0.0125 0.0162 0.0223
Brugia malayi MH2 domain containing protein 0.0121 0.0155 0.0213
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0124 0.016 0.0593
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0079 0.0089 0.0397
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0071 0.0229
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.002 0.0064
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0603 0.0927 0.4137
Trichomonas vaginalis AGC family protein kinase 0.0068 0.0071 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0227 0.0324 0.137
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0753 0.1167 0.4311
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0115 0.0146 0.0531
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0327 0.0486 0.0669
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0041 0.0028 0.0093
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0041 0.0028 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0099 0.0357

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.