Detailed information for compound 1320207

Basic information

Technical information
  • TDR Targets ID: 1320207
  • Name: N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[6,7 -dimethoxy-2,4-dioxo-3-(phenylmethyl)quinazol in-1-yl]acetamide
  • MW: 547.91 | Formula: C26H21ClF3N3O5
  • H donors: 1 H acceptors: 3 LogP: 4.66 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2c(cc1OC)n(CC(=O)Nc1cc(ccc1Cl)C(F)(F)F)c(=O)n(c2=O)Cc1ccccc1
  • InChi: 1S/C26H21ClF3N3O5/c1-37-21-11-17-20(12-22(21)38-2)32(25(36)33(24(17)35)13-15-6-4-3-5-7-15)14-23(34)31-19-10-16(26(28,29)30)8-9-18(19)27/h3-12H,13-14H2,1-2H3,(H,31,34)
  • InChiKey: LYAQEEKETBVEBU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[6,7-dimethoxy-2,4-dioxo-3-(phenylmethyl)-1-quinazolinyl]acetamide
  • 2-[3-(benzyl)-2,4-diketo-6,7-dimethoxy-quinazolin-1-yl]-N-[2-chloro-5-(trifluoromethyl)phenyl]acetamide
  • N-[2-chloro-5-(trifluoromethyl)phenyl]-2-[6,7-dimethoxy-2,4-dioxo-3-(phenylmethyl)quinazolin-1-yl]ethanamide
  • EU-0089941
  • C200-0954
  • NCGC00104896-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens flap structure-specific endonuclease 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium berghei flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Giardia lamblia Flap structure-specific endonuclease Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei gambiense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Neospora caninum flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium knowlesi flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Schistosoma japonicum ko:K04799 flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium falciparum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis flap endonuclease-1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Brugia malayi Flap endonuclease-1 Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium parvum flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania infantum flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Theileria parva flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Cryptosporidium hominis flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus flap endonuclease 1 Get druggable targets OG5_127472 All targets in OG5_127472
Babesia bovis XPG N-terminal domain and XPG I-region domain containing protein Get druggable targets OG5_127472 All targets in OG5_127472
Entamoeba histolytica Flap nuclease, putative Get druggable targets OG5_127472 All targets in OG5_127472
Leishmania braziliensis flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania donovani flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Plasmodium yoelii flap endonuclease-1-related Get druggable targets OG5_127472 All targets in OG5_127472
Plasmodium vivax flap endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii flap structure-specific endonuclease 1, putative Get druggable targets OG5_127472 All targets in OG5_127472
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative Get druggable targets OG5_127472 All targets in OG5_127472
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei exonuclease, putative flap structure-specific endonuclease 1 380 aa 322 aa 24.5 %
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0049 0.0015 0.0022
Brugia malayi Protein kinase domain containing protein 0.0169 0.0309 0.0456
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0049 0.0015 0.002
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0297 0.0624 0.1992
Brugia malayi ecdysteroid receptor 0.0063 0.0048 0.007
Leishmania major hypothetical protein, conserved 0.0064 0.0051 0.0292
Echinococcus granulosus rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Schistosoma mansoni hypothetical protein 0.0049 0.0015 0.0015
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Onchocerca volvulus 0.0064 0.0051 0.0117
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0122 0.0193 0.0284
Echinococcus granulosus two pore calcium channel protein 2 0.0049 0.0015 0.002
Echinococcus granulosus tachykinin peptides receptor 99D 0.0297 0.0624 0.0869
Echinococcus granulosus sodium leak channel non selective protein 0.0049 0.0015 0.002
Echinococcus granulosus FTZ F1 alpha 0.0063 0.0048 0.0066
Onchocerca volvulus 0.0096 0.013 0.0378
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0053
Echinococcus multilocularis neuropeptides capa receptor 0.0297 0.0624 0.0869
Schistosoma mansoni zinc finger protein 0.0064 0.0051 0.0051
Onchocerca volvulus 0.0297 0.0624 0.1992
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Mycobacterium ulcerans heat shock protein 90 0.0128 0.0207 1
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.014 0.0238 0.0331
Echinococcus granulosus Zinc finger RanBP2 type 0.0064 0.0051 0.007
Schistosoma mansoni hypothetical protein 0.018 0.0336 0.0336
Echinococcus multilocularis potassium large conductance calcium activated 0.0049 0.0015 0.002
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Echinococcus multilocularis sodium leak channel non selective protein 0.0049 0.0015 0.002
Trichomonas vaginalis heat shock protein, putative 0.0141 0.024 0.4106
Echinococcus granulosus voltage dependent calcium channel 0.0158 0.0283 0.0394
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0015 0.0015
Echinococcus granulosus neuropeptide FF receptor 2 0.0755 0.1755 0.2441
Echinococcus multilocularis transient receptor potential cation channel 0.0049 0.0015 0.002
Echinococcus granulosus neuropeptides capa receptor 0.0297 0.0624 0.0869
Schistosoma mansoni hypothetical protein 0.0075 0.0078 0.0078
Brugia malayi ephrin receptor 1 precursor 0.0091 0.0118 0.0173
Schistosoma mansoni ephrin receptor 0.0191 0.0364 0.0364
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Loa Loa (eye worm) hypothetical protein 0.0315 0.067 0.0968
Echinococcus granulosus potassium voltage gated channel protein 0.0049 0.0015 0.002
Echinococcus multilocularis sodium channel protein 0.0548 0.1243 0.1729
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0063 0.0048 0.0049
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0297 0.0624 0.0921
Brugia malayi ORL1-like opioid receptor 0.0297 0.0624 0.0921
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0711 0.1646 0.229
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0272 0.0564 0.0812
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0133 0.0221 0.0307
Echinococcus multilocularis somatostatin receptor 0.0297 0.0624 0.0869
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.0048 0.007
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0297 0.0624 0.0869
Echinococcus multilocularis transient receptor potential cation channel 0.0049 0.0015 0.002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0063 0.0048 0.0048
Onchocerca volvulus 0.0297 0.0624 0.1992
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0333 0.5799
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Toxoplasma gondii PAN domain-containing protein 0.0096 0.013 0.0324
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.018 0.0336 1
Onchocerca volvulus 0.0096 0.013 0.0378
Loa Loa (eye worm) hypothetical protein 0.0172 0.0317 0.0447
Schistosoma mansoni vesicular amine transporter 0.0049 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0096 0.013 0.0171
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.001 0.0014
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0158 0.0283 0.0394
Loa Loa (eye worm) hypothetical protein 0.0109 0.0162 0.0217
Echinococcus granulosus nmda type glutamate receptor 0.0112 0.0169 0.0236
Echinococcus multilocularis g protein coupled receptor 0.0297 0.0624 0.0869
Echinococcus granulosus hypothetical protein 0.0049 0.0015 0.002
Schistosoma mansoni protein kinase 0.014 0.0238 0.0238
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0158 0.0283 0.0418
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0297 0.0624 0.0624
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0064 0.0051 0.043
Echinococcus granulosus transient receptor potential cation channel 0.0049 0.0015 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0333 0.5799
Echinococcus multilocularis short transient receptor potential channel 6 0.0049 0.0015 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.0048 0.007
Brugia malayi Tachykinin-like peptides receptor 99D 0.0755 0.1755 0.2588
Echinococcus granulosus transient receptor potential cation channel 0.0049 0.0015 0.002
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.013 0.0171
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0112 0.0168 0.184
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.018 0.0336 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.013 0.0171
Brugia malayi G-protein coupled receptor 0.0297 0.0624 0.0921
Brugia malayi G protein-coupled receptor F59B2.13 0.0297 0.0624 0.0921
Toxoplasma gondii PAN domain-containing protein 0.0096 0.013 0.0324
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.024 0.2701
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis voltage gated potassium channel 0.0049 0.0015 0.002
Onchocerca volvulus 0.0297 0.0624 0.1992
Echinococcus multilocularis ecdysone induced protein 78C 0.0063 0.0048 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0297 0.0624 0.0624
Echinococcus granulosus adenylate cyclase 9 0.0063 0.0048 0.0067
Schistosoma mansoni thyroid hormone receptor 0.0063 0.0048 0.0048
Echinococcus multilocularis adenylate cyclase 9 0.0063 0.0048 0.0067
Toxoplasma gondii PAN domain-containing protein 0.1497 0.3582 1
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0158 0.0283 0.0394
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0158 0.0283 0.0394
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.0048 0.007
Leishmania major hypothetical protein, conserved 0.0064 0.0051 0.0292
Echinococcus granulosus g protein coupled receptor 0.0297 0.0624 0.0869
Onchocerca volvulus 0.0297 0.0624 0.1992
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0063 0.0048 0.0049
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0096 0.013 0.0324
Echinococcus multilocularis fmrfamide receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Schistosoma mansoni serine-type protease inhibitor 0.4101 1 1
Trypanosoma brucei heat shock protein, putative 0.0141 0.024 0.2701
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0711 0.1646 0.229
Schistosoma mansoni thyroid hormone receptor 0.0063 0.0048 0.0048
Brugia malayi Adenylyl cyclase protein 0.0063 0.0048 0.0071
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0333 0.5799
Toxoplasma gondii PAN/Apple domain-containing protein 0.0096 0.013 0.0324
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1365 0.3257 0.4531
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0049 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0064 0.0051 0.0051
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0112 0.0168 0.184
Echinococcus granulosus tm gpcr rhodopsin 0.0297 0.0624 0.0869
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0063 0.0048 0.0066
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0049 0.0015 0.0015
Echinococcus granulosus potassium voltage gated channel protein 0.0049 0.0015 0.002
Onchocerca volvulus Neuropeptide F receptor homolog 0.0297 0.0624 0.1992
Onchocerca volvulus 0.0297 0.0624 0.1992
Echinococcus granulosus voltage gated potassium channel 0.0049 0.0015 0.002
Leishmania major hypothetical protein, conserved 0.0064 0.0051 0.0292
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0049 0.0015 0.002
Loa Loa (eye worm) G-protein coupled receptor 0.0297 0.0624 0.0901
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Echinococcus multilocularis heat shock protein 90 0.0141 0.024 0.0334
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0297 0.0624 0.0624
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0049 0.0015 0.0022
Echinococcus granulosus allatostatin A receptor 0.1291 0.3075 0.4278
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0297 0.0624 0.0624
Onchocerca volvulus 0.0096 0.013 0.0378
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0107 0.1678
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Loa Loa (eye worm) hypothetical protein 0.0096 0.013 0.0171
Brugia malayi hypothetical protein 0.0297 0.0624 0.0921
Echinococcus multilocularis transient receptor potential cation channel 0.0049 0.0015 0.002
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0049 0.0015 0.002
Brugia malayi GnHR receptor homolog 0.0297 0.0624 0.0921
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0158 0.2613
Echinococcus multilocularis transfer RNA-Gly 0.0049 0.0015 0.002
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.001 0.0014
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0297 0.0624 0.0901
Echinococcus multilocularis SWI:SNF matrix associated 0.018 0.0336 0.0468
Echinococcus granulosus shaker cognate 0.0049 0.0015 0.002
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0128 0.0207 0.1569
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0333 0.5799
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0063 0.0048 0.0066
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0112 0.0168 0.184
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0049 0.0015 0.0022
Trypanosoma cruzi WLM domain containing protein, putative 0.0064 0.0051 0.043
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0048 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.1291 0.3075 0.4524
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0108 0.0158 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Echinococcus multilocularis orexin receptor type 2 0.0297 0.0624 0.0869
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0049 0.0015 0.0022
Echinococcus granulosus rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.013 0.0171
Echinococcus granulosus rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.2794 0.6779 1
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.024 0.2701
Loa Loa (eye worm) G-protein coupled receptor 0.0297 0.0624 0.0901
Toxoplasma gondii microneme protein MIC17C 0.0096 0.013 0.0324
Schistosoma mansoni apoptosis regulator bax 0.0315 0.067 0.067
Echinococcus granulosus tm gpcr rhodopsin 0.0297 0.0624 0.0869
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0063 0.0048 0.011
Echinococcus multilocularis g protein coupled receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) endoprotease bli-4 0.0143 0.0245 0.034
Schistosoma mansoni neuropeptide receptor 0.0297 0.0624 0.0624
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.024 1
Onchocerca volvulus 0.0064 0.0051 0.0117
Loa Loa (eye worm) hypothetical protein 0.0096 0.013 0.017
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0297 0.0624 0.0869
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0297 0.0624 0.0624
Brugia malayi neuropeptide F receptor 0.0297 0.0624 0.0921
Brugia malayi YY1-associated factor 2 0.0064 0.0051 0.0075
Brugia malayi Dopamine receptor 0.0297 0.0624 0.0921
Schistosoma mansoni hypothetical protein 0.018 0.0336 0.0336
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0122 0.0193 0.0263
Echinococcus granulosus transient receptor potential gamma protein 0.0049 0.0015 0.002
Trypanosoma brucei heat shock protein 90, putative 0.0141 0.024 0.2701
Schistosoma mansoni adenoreceptor 0.0297 0.0624 0.0624
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0063 0.0048 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.214 0.5168 0.7624
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) heat shock protein 90 0.0141 0.024 0.0333
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.024 0.2701
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0053
Echinococcus multilocularis hyperpolarization activated cyclic 0.0049 0.0015 0.002
Brugia malayi celfurPC protein 0.0115 0.0177 0.0261
Brugia malayi Caveolin-1 0.0526 0.1189 0.1753
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus granulosus transient receptor potential cation channel 0.0049 0.0015 0.002
Entamoeba histolytica heat shock protein 90, putative 0.0141 0.024 1
Brugia malayi Nuclear hormone receptor-like 1 0.0063 0.0048 0.007
Schistosoma mansoni glutamate receptor NMDA 0.0048 0.001 0.001
Echinococcus granulosus peptide allatostatin:somatostatin 0.0297 0.0624 0.0869
Echinococcus granulosus short transient receptor potential channel 6 0.0049 0.0015 0.002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0063 0.0048 0.007
Trichomonas vaginalis heat shock protein, putative 0.0128 0.0207 0.3508
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis shaker cognate 0.0049 0.0015 0.002
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0297 0.0624 0.0869
Echinococcus multilocularis zinc finger protein Ran binding 0.0064 0.0051 0.007
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0315 0.067 0.0932
Brugia malayi latrophilin 2 splice variant baaae 0.1429 0.3415 0.5038
Echinococcus multilocularis SWI:SNF matrix associated 0.018 0.0336 0.0468
Loa Loa (eye worm) calcium channel 0.0158 0.0283 0.0397
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0112 0.0168 0.184
Loa Loa (eye worm) endoplasmin 0.0141 0.024 0.0333
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.005
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0053
Echinococcus granulosus furin 0.0143 0.0245 0.0341
Brugia malayi hypothetical protein 0.0297 0.0624 0.0921
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.018 0.0336 0.0475
Echinococcus multilocularis ring and YY1 binding protein 0.0064 0.0051 0.007
Echinococcus granulosus hyperpolarization activated cyclic 0.0049 0.0015 0.002
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0064 0.0051 0.007
Echinococcus multilocularis G protein coupled receptor 139 0.0297 0.0624 0.0869
Trypanosoma brucei calpain-like protein, putative 0.0112 0.0168 0.184
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0064 0.0051 0.0075
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0297 0.0624 0.0869
Loa Loa (eye worm) hypothetical protein 0.0189 0.0359 0.0508
Trypanosoma brucei heat shock protein, putative 0.0141 0.024 0.2701
Onchocerca volvulus 0.0096 0.013 0.0378
Echinococcus granulosus transient receptor potential cation channel 0.0049 0.0015 0.002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0049 0.0015 0.002
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0049 0.0015 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0564 1
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0049 0.0015 0.002
Echinococcus granulosus heat shock protein 90 0.0141 0.024 0.0334
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0112 0.0168 0.184
Echinococcus multilocularis FTZ F1 alpha 0.0063 0.0048 0.0066
Brugia malayi G protein-coupled receptor 0.0297 0.0624 0.0921
Schistosoma mansoni neuropeptide f receptor 76f 0.0297 0.0624 0.0624
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1897 0.4567 0.6355
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0133 0.0221 0.0307
Echinococcus multilocularis transient receptor potential cation channel 0.0049 0.0015 0.002
Loa Loa (eye worm) brahma associated protein 0.018 0.0336 0.0475
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0333 0.5799
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0063 0.0048 0.007
Echinococcus granulosus potassium voltage gated channel protein 0.0049 0.0015 0.002
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.018 0.0336 0.0468
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0175 0.0323 0.1009
Schistosoma mansoni amine GPCR 0.0297 0.0624 0.0624
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.014 0.0238 0.0331
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0158 0.0158
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0158 0.0283 0.0394
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0564 1
Schistosoma mansoni protein kinase 0.014 0.0238 0.0238
Loa Loa (eye worm) bone morphogenic protein 6 0.0133 0.0221 0.0304
Echinococcus multilocularis neuropeptide Y receptor 0.0297 0.0624 0.0869
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1429 0.3415 0.5027
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0112 0.0168 0.1251
Trichomonas vaginalis heat shock protein, putative 0.0128 0.0207 0.3508
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0049 0.0015 0.002
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0158 0.2613
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Brugia malayi nuclear hormone receptor 0.0063 0.0048 0.007
Echinococcus multilocularis neuropeptide receptor A26 0.0818 0.1908 0.2655
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0049 0.0015 0.002
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0064 0.0051 0.043
Echinococcus granulosus ecdysone induced protein 78C 0.0063 0.0048 0.0066
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0297 0.0624 0.0921
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0049 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Brugia malayi larval opioid receptor 0.0297 0.0624 0.0921
Onchocerca volvulus 0.0096 0.013 0.0378
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0548 0.1243 0.1729
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0049
Schistosoma mansoni hypothetical protein 0.0711 0.1646 0.1646
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.013 0.0171
Onchocerca volvulus 0.0096 0.013 0.0378
Echinococcus multilocularis voltage gated potassium channel 0.0049 0.0015 0.002
Brugia malayi map kinase activated protein kinase protein 2 0.0181 0.0338 0.0498
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0049
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0049 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0526 0.1189 0.1735
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0063 0.0048 0.0048
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0297 0.0624 0.0624
Echinococcus multilocularis transient receptor potential gamma protein 0.0049 0.0015 0.002
Treponema pallidum heat shock protein 90 0.0128 0.0207 1
Trypanosoma cruzi heat shock protein 90, putative 0.0128 0.0207 0.2308
Echinococcus granulosus g-protein coupled receptor 0.0297 0.0624 0.0869
Brugia malayi brahma associated protein 60 kDa 0.018 0.0336 0.0496
Trypanosoma cruzi WLM domain containing protein, putative 0.0064 0.0051 0.043
Schistosoma mansoni growth hormone secretagogue receptor 0.0297 0.0624 0.0624
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0049 0.0015 0.002
Echinococcus granulosus potassium large conductance calcium activated 0.0049 0.0015 0.002
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0049 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0198 0.0382 0.0543
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0297 0.0624 0.0869
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0112 0.0168 0.184
Trypanosoma cruzi Heat shock protein 83, putative 0.0141 0.024 0.2701
Echinococcus multilocularis serotonin receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus granulosus glutamate receptor 2 0.0048 0.001 0.0014
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0049 0.0015 0.0015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0063 0.0048 0.0048
Schistosoma mansoni biogenic amine receptor 0.0297 0.0624 0.0624
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0063 0.0048 0.0049
Echinococcus granulosus heat shock protein 90 0.0128 0.0207 0.0289
Echinococcus multilocularis neuropeptide receptor 0.0297 0.0624 0.0869
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0297 0.0624 0.0869
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0297 0.0624 0.0901
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0063 0.0048 0.0066
Schistosoma mansoni amine GPCR 0.0297 0.0624 0.0624
Trypanosoma brucei hypothetical protein 0.0112 0.0168 0.184
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Schistosoma mansoni voltage-gated cation channel 0.0158 0.0283 0.0283
Echinococcus multilocularis ephrin type A receptor 4 A 0.0191 0.0364 0.0506
Schistosoma mansoni hypothetical protein 0.0315 0.067 0.067
Toxoplasma gondii microneme protein MIC17A 0.0096 0.013 0.0324
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Trypanosoma cruzi heat shock protein 90, putative 0.0141 0.024 0.2701
Onchocerca volvulus 0.0297 0.0624 0.1992
Echinococcus multilocularis neuroendocrine convertase 2 0.009 0.0114 0.0159
Echinococcus granulosus neuropeptide receptor 0.0297 0.0624 0.0869
Echinococcus granulosus voltage dependent calcium channel 0.0158 0.0283 0.0394
Echinococcus multilocularis potassium voltage gated channel protein 0.0049 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.2794 0.6779 1
Echinococcus granulosus adenylate cyclase type IX 0.0089 0.0111 0.0155
Brugia malayi cation channel family protein 0.0049 0.0015 0.0022
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0049 0.0015 0.0022
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0297 0.0624 0.0624
Schistosoma mansoni transient receptor potential channel 0.0049 0.0015 0.0015
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0388 0.085 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0297 0.0624 0.0901
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Echinococcus granulosus G protein coupled receptor 139 0.0297 0.0624 0.0869
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Loa Loa (eye worm) voltage-dependent calcium channel 0.0158 0.0283 0.0397
Echinococcus multilocularis two pore calcium channel protein 2 0.0049 0.0015 0.002
Brugia malayi Transforming growth factor beta like domain containing protein 0.0133 0.0221 0.0326
Schistosoma mansoni opsin-like receptor 0.0297 0.0624 0.0624
Toxoplasma gondii heat shock protein 90, putative 0.0141 0.024 0.0632
Echinococcus multilocularis rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Schistosoma mansoni coup transcription factor 0.0063 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.001 0.0014
Echinococcus multilocularis glutamate receptor 2 0.0048 0.001 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.0063 0.0048 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Echinococcus multilocularis rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0564 1
Loa Loa (eye worm) neuropeptide F receptor 0.0297 0.0624 0.0901
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1365 0.3257 0.4531
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0049 0.0015 0.0015
Schistosoma mansoni brg-1 associated factor 0.018 0.0336 0.0336
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Schistosoma mansoni biogenic amine receptor 0.0297 0.0624 0.0624
Echinococcus multilocularis GPCR, family 2 0.0711 0.1646 0.229
Onchocerca volvulus 0.0297 0.0624 0.1992
Echinococcus granulosus rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Echinococcus multilocularis potassium voltage gated channel protein 0.0049 0.0015 0.002
Toxoplasma gondii subtilisin SUB12 0.0102 0.0145 0.0366
Loa Loa (eye worm) melatonin receptor type 1A 0.0297 0.0624 0.0901
Onchocerca volvulus 0.0297 0.0624 0.1992
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0049 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0711 0.1646 0.1646
Loa Loa (eye worm) hypothetical protein 0.0158 0.0283 0.0397
Echinococcus multilocularis conserved hypothetical protein 0.0049 0.0015 0.002
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0158 0.0283 0.0394
Echinococcus granulosus SWI:SNF matrix associated 0.018 0.0336 0.0468
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Trypanosoma cruzi heat shock protein 90, putative 0.0114 0.0174 0.191
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0297 0.0624 0.0624
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0333 0.5799
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0049
Onchocerca volvulus 0.0297 0.0624 0.1992
Schistosoma mansoni opsin-like receptor 0.0297 0.0624 0.0624
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0051 0.043
Brugia malayi hypothetical protein 0.1362 0.3248 0.4792
Trypanosoma brucei calpain, putative 0.0112 0.0168 0.184
Echinococcus granulosus short transient receptor potential channel 6 0.0049 0.0015 0.002
Schistosoma mansoni ryanodine receptor related 0.0049 0.0015 0.0015
Echinococcus granulosus serotonin receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0108 0.0158 0.0212
Brugia malayi nuclear receptor NHR-88 0.0063 0.0048 0.007
Schistosoma mansoni alpha-1 adrenergic receptor 0.0297 0.0624 0.0624
Onchocerca volvulus 0.0189 0.0359 0.1124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0063 0.0048 0.007
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0297 0.0624 0.0901
Echinococcus multilocularis thyroid hormone receptor alpha 0.0063 0.0048 0.0066
Schistosoma mansoni furin-1 (S08 family) 0.0062 0.0046 0.0046
Echinococcus granulosus neuropeptide s receptor 0.0818 0.1908 0.2655
Brugia malayi Latrophilin receptor protein 2 0.0711 0.1646 0.2428
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0297 0.0624 0.0869
Schistosoma mansoni two-pore calcium channel 0.0049 0.0015 0.0015
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0158 0.0283 0.0283
Schistosoma mansoni biogenic amine (5HT) receptor 0.0297 0.0624 0.0624
Echinococcus multilocularis allatostatin A receptor 0.1291 0.3075 0.4278
Brugia malayi RE15519p 0.0297 0.0624 0.0921
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0048 0.001 0.0014
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis heat shock protein 90 0.0128 0.0207 0.0289
Echinococcus multilocularis rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0064 0.0051 0.0117
Echinococcus multilocularis g-protein coupled receptor 0.0297 0.0624 0.0869
Echinococcus multilocularis nmda type glutamate receptor 0.0112 0.0169 0.0236
Brugia malayi Serotonin receptor 0.0297 0.0624 0.0921
Schistosoma mansoni hypothetical protein 0.0297 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0158 0.0283 0.3218
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0063 0.0048 0.0066
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0181 0.0338 0.047
Brugia malayi AKH receptor 0.0297 0.0624 0.0921
Brugia malayi Dopamine receptor protein 1 0.0297 0.0624 0.0921
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0063 0.0048 0.0048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0297 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis voltage dependent calcium channel 0.0158 0.0283 0.0394
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Brugia malayi steroid hormone receptor 0.0063 0.0048 0.007
Echinococcus granulosus heat shock protein 0.0141 0.024 0.0334
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0158 0.0283 0.0283
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0051 0.043
Chlamydia trachomatis SWIB complex protein 0.018 0.0336 1
Schistosoma mansoni jun-related protein 0.0075 0.0078 0.0078
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0049 0.0015 0.0022
Schistosoma mansoni heat shock protein 0.0141 0.024 0.024
Schistosoma mansoni transient receptor potential channel 0.0049 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Loa Loa (eye worm) hypothetical protein 0.0167 0.0305 0.0429
Echinococcus granulosus ring and YY1 binding protein 0.0064 0.0051 0.007
Toxoplasma gondii microneme protein, putative 0.0096 0.013 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0564 1
Brugia malayi proprotein convertase 2 0.009 0.0114 0.0168
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0297 0.0624 0.0869
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0064 0.0051 0.043
Toxoplasma gondii hypothetical protein 0.0096 0.013 0.0324
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0049
Echinococcus multilocularis potassium voltage gated channel protein 0.0049 0.0015 0.002
Echinococcus granulosus fmrfamide receptor 0.0297 0.0624 0.0869
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0063 0.0048 0.007
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0128 0.0207 0.0289
Loa Loa (eye worm) hypothetical protein 0.0096 0.013 0.0171
Onchocerca volvulus 0.0096 0.013 0.0378
Trypanosoma brucei heat shock protein, putative 0.0141 0.024 0.2701
Schistosoma mansoni opsin-like receptor 0.0297 0.0624 0.0624
Echinococcus granulosus sex peptide receptor 0.0297 0.0624 0.0869
Echinococcus multilocularis g protein coupled receptor 0.0297 0.0624 0.0869
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0107 0.1678
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis fmrfamide receptor 0.0297 0.0624 0.0869
Echinococcus granulosus g protein coupled receptor 0.0297 0.0624 0.0869
Echinococcus granulosus biogenic amine 5HT receptor 0.0297 0.0624 0.0869
Echinococcus granulosus calcium activated potassium channel 0.0051 0.0019 0.0027
Toxoplasma gondii ran binding protein 0.0064 0.0051 0.0101
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0181 0.0338 0.047
Trichomonas vaginalis conserved hypothetical protein 0.018 0.0336 0.5854
Echinococcus multilocularis ryanodine receptor 44f 0.0049 0.0015 0.002
Schistosoma mansoni glutamate receptor NMDA 0.0266 0.0547 0.0547
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0112 0.0168 0.184
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0049 0.0015 0.002
Schistosoma mansoni neuropeptide receptor 0.0297 0.0624 0.0624
Giardia lamblia Heat shock protein HSP 90-alpha 0.0141 0.024 1
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0564 1
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0049 0.0015 0.002
Onchocerca volvulus 0.1291 0.3075 1
Brugia malayi hypothetical protein 0.0073 0.0072 0.0107
Loa Loa (eye worm) steroid hormone receptor 0.0063 0.0048 0.0049
Brugia malayi G-protein coupled receptor 0.0297 0.0624 0.0921
Toxoplasma gondii microneme protein MIC17B 0.0096 0.013 0.0324
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0297 0.0624 0.0901
Brugia malayi hypothetical protein 0.0297 0.0624 0.0921
Schistosoma mansoni hypothetical protein 0.0297 0.0624 0.0624
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0272 0.0564 0.0832
Brugia malayi hypothetical protein 0.0049 0.0015 0.0022
Schistosoma mansoni transient receptor potential channel 0.0049 0.0015 0.0015
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.013 0.0171
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0297 0.0624 0.0869
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0048 0.0066
Brugia malayi phosphoinositide-dependent protein kinase I 0.0108 0.0158 0.0233
Schistosoma mansoni amine GPCR 0.0297 0.0624 0.0624
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0064 0.0051 0.0101
Schistosoma mansoni heat shock protein 0.0141 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.009 0.0115 0.0148
Echinococcus multilocularis short transient receptor potential channel 6 0.0049 0.0015 0.002
Toxoplasma gondii PAN domain-containing protein 0.1497 0.3582 1
Plasmodium falciparum heat shock protein 90 0.0141 0.024 0.6637
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0049 0.0015 0.0015
Brugia malayi olfactory channel protein osm-9 0.0049 0.0015 0.0022
Brugia malayi hypothetical protein 0.0297 0.0624 0.0921
Echinococcus granulosus GPCR family 2 0.0711 0.1646 0.229
Schistosoma mansoni hypothetical protein 0.0711 0.1646 0.1646
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0297 0.0624 0.0869
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0297 0.0624 0.0921
Brugia malayi neuropeptide F receptor 0.0297 0.0624 0.0921
Echinococcus multilocularis calcium activated potassium channel 0.0051 0.0019 0.0027
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0049 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0755 0.1755 0.2572
Toxoplasma gondii PAN domain-containing protein 0.0096 0.013 0.0324
Echinococcus granulosus rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Loa Loa (eye worm) hypothetical protein 0.0158 0.0283 0.0397
Schistosoma mansoni hypothetical protein 0.0297 0.0624 0.0624
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0112 0.0168 0.184
Schistosoma mansoni amine GPCR 0.0297 0.0624 0.0624
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0128 0.0207 1
Echinococcus multilocularis neuropeptide s receptor 0.0818 0.1908 0.2655
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0297 0.0624 0.0869
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0064 0.0051 0.0075
Trichomonas vaginalis heat shock protein, putative 0.0128 0.0207 0.3508
Echinococcus multilocularis sex peptide receptor 0.0297 0.0624 0.0869
Echinococcus granulosus TRP transient receptor potential channel 0.0049 0.0015 0.002
Loa Loa (eye worm) TK/EPH protein kinase 0.0243 0.0491 0.0705
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis 0.0115 0.0177 0.0246
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0297 0.0624 0.0869
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0049 0.0015 0.0022
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Onchocerca volvulus 0.0297 0.0624 0.1992
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0063 0.0048 0.0049
Echinococcus granulosus transient receptor potential cation channel 0.0049 0.0015 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0063 0.0048 0.0049
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0049
Brugia malayi endoprotease bli-4 precursor 0.0143 0.0245 0.0361
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0108 0.0158 0.022
Schistosoma mansoni hypothetical protein 0.0315 0.067 0.067
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0049 0.0015 0.002
Onchocerca volvulus 0.0073 0.0072 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0063 0.0048 0.007
Echinococcus granulosus potassium voltage gated channel protein 0.0049 0.0015 0.002
Brugia malayi hypothetical protein 0.0297 0.0624 0.0921
Schistosoma mansoni endoplasmin 0.0141 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0096 0.013 0.0171
Leishmania major C-8 sterol isomerase-like protein 0.0388 0.085 0.6798
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0064 0.0051 0.007
Plasmodium vivax hypothetical protein, conserved 0.018 0.0336 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0297 0.0624 0.0869
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0063 0.0048 0.0066
Schistosoma mansoni protein kinase 0.014 0.0238 0.0238
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0064 0.0051 0.043
Trypanosoma cruzi heat shock protein 85, putative 0.0141 0.024 0.2701
Echinococcus granulosus g protein coupled receptor 0.0297 0.0624 0.0869
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0049 0.0015 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0297 0.0624 0.0624
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0112 0.0168 0.184
Echinococcus granulosus jun protein 0.0093 0.0121 0.0169
Echinococcus granulosus neuropeptide receptor A26 0.0818 0.1908 0.2655
Onchocerca volvulus 0.0064 0.0051 0.0117
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0093 0.0121 0.0169
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0049 0.0015 0.0015
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0112 0.0168 0.184
Loa Loa (eye worm) apoptosis regulator protein 0.0315 0.067 0.0968
Echinococcus granulosus somatostatin receptor 0.0297 0.0624 0.0869
Echinococcus granulosus 7tm_1 domain containing protein 0.0297 0.0624 0.0869
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0388 0.085 0.1253
Loa Loa (eye worm) hypothetical protein 0.0096 0.013 0.0171
Trypanosoma brucei hypothetical protein, conserved 0.0064 0.0051 0.043
Trypanosoma brucei C-8 sterol isomerase, putative 0.0388 0.085 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0297 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Echinococcus multilocularis rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Brugia malayi Steroid receptor seven-up type 2 0.0063 0.0048 0.007
Brugia malayi Dopamine receptor protein 2 0.0297 0.0624 0.0921
Onchocerca volvulus 0.0297 0.0624 0.1992
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0063 0.0048 0.0048
Schistosoma mansoni voltage-gated ion channel 0.0049 0.0015 0.0015
Echinococcus granulosus neuropeptide Y receptor 0.0297 0.0624 0.0869
Echinococcus multilocularis dro:myosuppressin receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) TYRA-2 protein 0.0297 0.0624 0.0901
Onchocerca volvulus 0.0096 0.013 0.0378
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0297 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0049
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1291 0.3075 0.3075
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0158 0.2613
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0049 0.0015 0.0022
Schistosoma mansoni hypothetical protein 0.018 0.0336 0.0336
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0297 0.0624 0.0921
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0053
Trypanosoma brucei heat shock protein, putative 0.0141 0.024 0.2701
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0049 0.0015 0.002
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0548 0.1243 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0063 0.0048 0.007
Onchocerca volvulus 0.0096 0.013 0.0378
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.001 0.0014
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0297 0.0624 0.0624
Schistosoma mansoni neuropeptide F-like receptor 0.0297 0.0624 0.0624
Echinococcus granulosus ryanodine receptor 44f 0.0049 0.0015 0.002
Echinococcus granulosus biogenic amine 5HT receptor 0.0297 0.0624 0.0869
Echinococcus granulosus orexin receptor type 2 0.0297 0.0624 0.0869
Schistosoma mansoni myosin xvIII 0.0297 0.0624 0.0624
Chlamydia trachomatis DNA topoisomerase I 0.018 0.0336 1
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0049 0.0015 0.002
Echinococcus multilocularis neuropeptide receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Loa Loa (eye worm) latrophilin receptor protein 2 0.0711 0.1646 0.2411
Echinococcus multilocularis hyperpolarization activated cyclic 0.0049 0.0015 0.002
Trypanosoma cruzi heat shock protein 85, putative 0.0128 0.0207 0.2308
Echinococcus granulosus hyperpolarization activated cyclic 0.0049 0.0015 0.002
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0108 0.0158 0.022
Schistosoma mansoni histamine h1 receptor 0.0297 0.0624 0.0624
Echinococcus multilocularis transient receptor potential cation channel 0.0049 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0711 0.1646 0.1646
Loa Loa (eye worm) hypothetical protein 0.0109 0.0162 0.0217
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0315 0.067 0.0932
Echinococcus multilocularis serotonin receptor 0.0297 0.0624 0.0869
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0049 0.0015 0.0015
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0128 0.0207 0.5
Onchocerca volvulus 0.0063 0.0048 0.0107
Trypanosoma brucei RNA helicase, putative 0.0316 0.0671 0.7866
Brugia malayi voltage-dependent calcium channel 0.0049 0.0015 0.0022
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0087 0.0107 0.0149
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus granulosus zinc finger protein Ran binding 0.0064 0.0051 0.007
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0049 0.0015 0.0022
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.296 0.7188 1
Brugia malayi brahma associated protein 60 kDa 0.018 0.0336 0.0496
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0015 0.0015
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0049 0.0015 0.0022
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0158 0.0283 0.0394
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Echinococcus granulosus neuropeptide Y receptor 0.0297 0.0624 0.0869
Schistosoma mansoni RNA binding protein 0.0064 0.0051 0.0051
Toxoplasma gondii hypothetical protein 0.0109 0.0162 0.0412
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0315 0.067 0.0988
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0049 0.0015 0.0015
Echinococcus granulosus neuropeptide receptor 0.0297 0.0624 0.0869
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0093 0.0121 0.0169
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0143 0.0245 0.0245
Echinococcus granulosus dro:myosuppressin receptor 0.0297 0.0624 0.0869
Schistosoma mansoni fusion 0.0064 0.0051 0.0051
Brugia malayi hypothetical protein 0.0297 0.0624 0.0921
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.296 0.7188 1
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.018 0.0336 0.0901
Toxoplasma gondii heat shock protein HSP90 0.0141 0.024 0.0632
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0063 0.0048 0.007
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis G-protein coupled receptor, putative 0.0297 0.0624 0.0869
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0297 0.0624 0.0921
Echinococcus multilocularis endoplasmin 0.0128 0.0207 0.0289
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Brugia malayi ion channel NompC 0.0049 0.0015 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0357 0.623
Schistosoma mansoni biogenic amine receptor 0.0297 0.0624 0.0624
Trypanosoma brucei heat shock protein, putative 0.0141 0.024 0.2701
Onchocerca volvulus 0.0297 0.0624 0.1992
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Schistosoma mansoni transient receptor potential channel 4 0.0049 0.0015 0.0015
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0158 0.0283 0.3218
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0049 0.0015 0.0015
Brugia malayi putative neuropeptide receptor NPR1 0.0297 0.0624 0.0921
Brugia malayi putative neuropeptide receptor 0.0297 0.0624 0.0921
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0128 0.0207 0.5
Schistosoma mansoni endoplasmin 0.0141 0.024 0.024
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0063 0.0048 0.0066
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Giardia lamblia Grp94/Hsp90 0.0128 0.0207 0.8485
Onchocerca volvulus Bile acid receptor homolog 0.0063 0.0048 0.0107
Echinococcus granulosus neuropeptides capa receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0064 0.0051 0.0075
Loa Loa (eye worm) PAN domain-containing protein 0.0096 0.013 0.0171
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0181 0.0338 0.0478
Echinococcus multilocularis heat shock protein 0.0141 0.024 0.0334
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Schistosoma mansoni hypothetical protein 0.0315 0.067 0.067
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0087 0.0107 0.0149
Loa Loa (eye worm) hypothetical protein 0.0056 0.0031 0.0024
Echinococcus multilocularis neuropeptides capa receptor 0.0297 0.0624 0.0869
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis neuropeptide Y receptor 0.0297 0.0624 0.0869
Echinococcus multilocularis jun protein 0.0093 0.0121 0.0169
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0049 0.0015 0.0015
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0049 0.0015 0.002
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Brugia malayi Serotonin receptor 0.0297 0.0624 0.0921
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Onchocerca volvulus 0.0096 0.013 0.0378
Echinococcus granulosus ephrin type A receptor 4 A 0.0191 0.0364 0.0506
Brugia malayi Transient-receptor-potential like protein 0.0049 0.0015 0.0022
Leishmania major hypothetical protein, conserved 0.0064 0.0051 0.0292
Echinococcus granulosus tm gpcr rhodopsin 0.1897 0.4567 0.6355
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0063 0.0048 0.0066
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0112 0.0168 0.1251
Echinococcus granulosus potassium voltage gated channel protein 0.0049 0.0015 0.002
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0063 0.0048 0.0066
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0297 0.0624 0.0624
Schistosoma mansoni neuropeptide F-like receptor 0.0297 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Echinococcus multilocularis SWI:SNF matrix associated 0.018 0.0336 0.0468
Schistosoma mansoni calcium-activated potassium channel 0.0049 0.0015 0.0015
Echinococcus granulosus alpha 1A adrenergic receptor 0.0297 0.0624 0.0869
Brugia malayi hypothetical protein 0.0297 0.0624 0.0921
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.001 0.0014
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Echinococcus granulosus two pore calcium channel protein 1 0.0049 0.0015 0.002
Brugia malayi hypothetical protein 0.0297 0.0624 0.0921
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.018 0.0336 0.0901
Loa Loa (eye worm) hypothetical protein 0.0064 0.0051 0.0053
Onchocerca volvulus 0.0297 0.0624 0.1992
Brugia malayi sulfakinin receptor protein 0.1362 0.3248 0.4792
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Onchocerca volvulus 0.018 0.0336 0.105
Brugia malayi cation channel family protein 0.0049 0.0015 0.0022
Brugia malayi bZIP transcription factor family protein 0.0093 0.0121 0.0179
Trypanosoma brucei heat shock protein, putative 0.0141 0.024 0.2701
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0297 0.0624 0.0624
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0158 0.0283 0.0394
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0297 0.0624 0.0624
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0112 0.0168 0.1251
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0049 0.0015 0.002
Echinococcus granulosus glutamate NMDA receptor subunit 0.0266 0.0547 0.0762
Schistosoma mansoni RAR-like nuclear receptor 0.0063 0.0048 0.0048
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0297 0.0624 0.0869
Toxoplasma gondii hypothetical protein 0.0096 0.013 0.0324
Schistosoma mansoni amine GPCR 0.0297 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.0297 0.0624 0.0624
Schistosoma mansoni hypothetical protein 0.1429 0.3415 0.3415
Entamoeba histolytica protein kinase, putative 0.0108 0.0158 0.6588
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0266 0.0547 0.0762
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.018 0.0336 1
Schistosoma mansoni neuropeptide receptor 0.0297 0.0624 0.0624
Giardia lamblia Heat shock protein HSP 90-alpha 0.0128 0.0207 0.8485
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0063 0.0048 0.0048
Trypanosoma brucei heat shock protein, putative 0.0141 0.024 0.2701
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0049 0.0015 0.002
Onchocerca volvulus 0.0297 0.0624 0.1992
Onchocerca volvulus 0.0096 0.013 0.0378
Leishmania major hypothetical protein, conserved 0.0064 0.0051 0.0292
Loa Loa (eye worm) hypothetical protein 0.1362 0.3248 0.4781
Brugia malayi neuroendocrine convertase 1 precursor 0.009 0.0114 0.0168
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0049 0.0015 0.002
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0015 0.0015
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.0333 0.104
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0064 0.0051 0.043
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Loa Loa (eye worm) hypothetical protein 0.0096 0.013 0.0171
Echinococcus multilocularis two pore calcium channel protein 1 0.0049 0.0015 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0063 0.0048 0.0066
Loa Loa (eye worm) hypothetical protein 0.0388 0.085 0.1234
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.001 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0297 0.0624 0.0624
Onchocerca volvulus 0.0297 0.0624 0.1992
Onchocerca volvulus 0.0063 0.0048 0.011
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Echinococcus granulosus endoplasmin 0.0128 0.0207 0.0289
Trichomonas vaginalis glucosylceramidase, putative 0.0188 0.0357 0.623
Echinococcus multilocularis adenylate cyclase type IX 0.0089 0.0111 0.0155
Schistosoma mansoni retinoic acid receptor RXR 0.0063 0.0048 0.0048
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0112 0.0168 0.184
Brugia malayi hypothetical protein 0.0297 0.0624 0.0921
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0048 0.0066
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0049
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Schistosoma mansoni TRABID protein (C64 family) 0.0064 0.0051 0.0051
Loa Loa (eye worm) adenylyl cyclase 3 0.0149 0.026 0.0362
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0051 0.043
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0112 0.0168 0.184
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0063 0.0048 0.007
Trypanosoma brucei heat shock protein, putative 0.0141 0.024 0.2701
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Onchocerca volvulus 0.0297 0.0624 0.1992
Echinococcus multilocularis rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0297 0.0624 0.0869
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0297 0.0624 0.0624
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0711 0.1646 0.2428
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0063 0.0048 0.007
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0015 0.0015
Echinococcus multilocularis neuropeptide FF receptor 2 0.0755 0.1755 0.2441
Brugia malayi Protein kinase domain containing protein 0.0108 0.0158 0.0233
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0049 0.0015 0.0015
Echinococcus granulosus sodium channel protein 0.0548 0.1243 0.1729
Echinococcus multilocularis rhodopsin orphan GPCR 0.0297 0.0624 0.0869
Echinococcus granulosus voltage gated potassium channel 0.0049 0.0015 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0297 0.0624 0.0624
Toxoplasma gondii transporter, cation channel family protein 0.0158 0.0283 0.0753
Onchocerca volvulus 0.006 0.0042 0.0088
Echinococcus granulosus 7TM GPCR rhodopsin 0.0297 0.0624 0.0869
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0297 0.0624 0.0624
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0063 0.0048 0.0066
Echinococcus granulosus transient receptor potential cation channel 0.0049 0.0015 0.002
Loa Loa (eye worm) neuropeptide F receptor 0.0297 0.0624 0.0901
Schistosoma mansoni hypothetical protein 0.0316 0.0671 0.0671
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0297 0.0624 0.0624
Brugia malayi photoreceptor-specific nuclear receptor 0.0063 0.0048 0.007
Loa Loa (eye worm) pigment dispersing factor receptor c 0.214 0.5168 0.7619
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0297 0.0624 0.0869
Echinococcus multilocularis transient receptor potential cation channel 0.0049 0.0015 0.002
Schistosoma mansoni biogenic amine (5HT) receptor 0.0297 0.0624 0.0624
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0064 0.0051 0.007
Brugia malayi heat shock protein 90 0.0141 0.024 0.0354
Trypanosoma cruzi hypothetical protein, conserved 0.0064 0.0051 0.043
Brugia malayi PAN domain containing protein 0.0096 0.013 0.0192
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Schistosoma mansoni 60S ribosomal protein L21 0.0049 0.0015 0.0015
Schistosoma mansoni nuclear hormone receptor 0.0063 0.0048 0.0048
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0049 0.0015 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0272 0.0564 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0049 0.0015 0.0022
Echinococcus multilocularis potassium voltage gated channel protein 0.0049 0.0015 0.002
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Onchocerca volvulus 0.0064 0.0051 0.0117
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0064 0.0051 0.0075
Brugia malayi Endoplasmin precursor 0.0141 0.024 0.0354
Schistosoma mansoni voltage-dependent calcium channel 0.0049 0.0015 0.0015
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0063 0.0048 0.0107
Toxoplasma gondii PAN domain-containing protein 0.0096 0.013 0.0324
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0063 0.0048 0.0066
Echinococcus granulosus Upstream activation factor subunit UAF30 0.018 0.0336 0.0468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0063 0.0048 0.0049
Schistosoma mansoni neuropeptide receptor 0.0297 0.0624 0.0624
Brugia malayi SWIB/MDM2 domain containing protein 0.018 0.0336 0.0496
Echinococcus granulosus neuroendocrine convertase 2 0.009 0.0114 0.0159
Loa Loa (eye worm) hypothetical protein 0.0711 0.1646 0.2411
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Onchocerca volvulus Protein ultraspiracle homolog 0.0063 0.0048 0.0107
Echinococcus multilocularis voltage dependent calcium channel 0.0158 0.0283 0.0394
Brugia malayi follicle stimulating hormone receptor 0.0297 0.0624 0.0921
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0315 0.067 0.067
Toxoplasma gondii microneme protein MIC4 0.0096 0.013 0.0324
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0049 0.0015 0.002
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0049 0.0015 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0181 0.0338 0.0338
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0049 0.0015 0.0022
Loa Loa (eye worm) hypothetical protein 0.0297 0.0624 0.0901
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0064 0.0051 0.043
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0297 0.0624 0.0869
Brugia malayi Melatonin receptor type 1A 0.0297 0.0624 0.0921
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0063 0.0048 0.007
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0112 0.0169 0.0236
Trypanosoma brucei Heat shock protein 83, putative 0.0141 0.024 0.2701
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0049 0.0015 0.002
Leishmania major heat shock protein 83-1 0.0141 0.024 0.1836
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0064 0.0051 0.043
Echinococcus granulosus hypothetical protein 0.0297 0.0624 0.0869
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0015 0.0015
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0049 0.0015 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.0333 0.5799
Echinococcus granulosus voltage gated hydrogen channel 1 0.0049 0.0015 0.002
Loa Loa (eye worm) hypothetical protein 0.0143 0.0245 0.034

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 3.2643 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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