TDR Targets

Basic information

Technical information

TDR Targets ID: 1337890
Name: (4-methoxyphenyl)methyl N-[[(3aS,5aS,8R,9S,9a S,9bS)-8,9-dihydroxy-1,3-dioxo-2-[[(2S)-oxola n-2-yl]methyl]-4,5,5a,7,8,9,9a,9b-octahydro-3 aH-benzo[e]isoindol-6-ylidene]amino]carbamate
MW: 515.556 | Formula: C26H33N3O8
H donors: 3 H acceptors: 5 LogP: 0.28 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1)COC(=O)N/N=C\1/C[C@@H](O)[C@H]([C@H]2[C@@H]1CC[C@H]1[C@H]2C(=O)N(C1=O)C[C@@H]1CCCO1)O
InChi: 1S/C26H33N3O8/c1-35-15-6-4-14(5-7-15)13-37-26(34)28-27-19-11-20(30)23(31)21-17(19)8-9-18-22(21)25(33)29(24(18)32)12-16-3-2-10-36-16/h4-7,16-18,20-23,30-31H,2-3,8-13H2,1H3,(H,28,34)/b27-19-/t16-,17+,18-,20+,21-,22+,23+/m0/s1
InChiKey: FVIMMMWJEUMOOO-GRFUVRMUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(4-methoxyphenyl)methyl N-[[(3aS,5aS,8R,9S,9aS,9bS)-8,9-dihydroxy-1,3-dioxo-2-[[(2S)-tetrahydrofuran-2-yl]methyl]-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol-6-ylidene]amino]carbamate
N-[[(3aS,5aS,8R,9S,9aS,9bS)-8,9-dihydroxy-1,3-dioxo-2-[[(2S)-2-tetrahydrofuranyl]methyl]-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol-6-ylidene]amino]carbamic acid (4-methoxyphenyl)methyl ester
N-[[(3aS,5aS,8R,9S,9aS,9bS)-8,9-dihydroxy-1,3-diketo-2-(tetrahydrofurfuryl)-4,5,5a,7,8,9,9a,9b-octahydro-3aH-benzo[e]isoindol-6-ylidene]amino]carbamic acid (4-methoxybenzyl) ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0081	0.3115
Loa Loa (eye worm)	glutathione reductase	0.0047	0.0188	0.0188
Schistosoma mansoni	ferritin light chain	0.001	0.002	0.002
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0385	0.1707	0.1707
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0006	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0486
Trichomonas vaginalis	hypothetical protein	0.0006	0	0.0063
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0006	0.0006
Plasmodium falciparum	bromodomain protein 1	0.0006	0	0.00000040179
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.0076	0.0148
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0048	0.0048
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0016	0.0048	0.1753
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0006	0	0.0063
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0104	0.0104
Mycobacterium ulcerans	bacterioferritin BfrA	0.001	0.002	0.0601
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Loa Loa (eye worm)	CBP-B	0.0231	0.1011	0.1011
Toxoplasma gondii	methionine aminopeptidase	0.0029	0.0106	0.4252
Brugia malayi	Bromodomain containing protein	0.0007	0.0008	0.0008
Schistosoma mansoni	ap endonuclease	0.0023	0.0076	0.0076
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0248	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Toxoplasma gondii	methionine aminopeptidase	0.0046	0.0182	0.7319
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Schistosoma mansoni	ferritin	0.001	0.002	0.002
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0076	1
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0046	0.0182	0.0182
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0048	0.6321
Echinococcus multilocularis	CREB binding protein	0.0054	0.0219	0.0219
Plasmodium vivax	hypothetical protein, conserved	0.0006	0	0.00000040179
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0029	0.0106	0.0105
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0048	0.0093
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0048	0.0093
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0046	0.0182	0.0182
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Echinococcus granulosus	microtubule associated protein 2	0.0833	0.3721	0.372
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0014	0.0014
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0081	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0054	0.0054
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.0006	0.001
Schistosoma mansoni	CREB-binding protein 2	0.0332	0.1467	0.1467
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0076	0.0076
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0016	0.0048	0.1753
Onchocerca volvulus		0.0385	0.1707	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0007	0.0006
Toxoplasma gondii	bromodomain-containing protein	0.0006	0	0.00000030351
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0486
Echinococcus multilocularis	calcium activated potassium channel	0.0009	0.0015	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0486
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0081	0.3115
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0486
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0048	0.0093
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0246	0.9905
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein 4, brd4, putative	0.0006	0	0.0063
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0007	0.0006
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0004	0.0486
Trichomonas vaginalis	hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Mycobacterium tuberculosis	Probable reductase	0.0108	0.0461	0.8943
Treponema pallidum	NADH oxidase	0.0016	0.0048	0.3267
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0048	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0385	0.1707	0.1707
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0029	0.0106	0.2033
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0006	0.001
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.005	0.0097
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0006	0.0006
Echinococcus multilocularis	zinc finger protein	0.0007	0.0008	0.0007
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0076	0.4054
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0007	0.0006
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0048	0.2553
Onchocerca volvulus		0.0007	0.0006	0.0031
Loa Loa (eye worm)	ShTK domain-containing protein	0.0385	0.1707	0.1707
Plasmodium falciparum	glutathione reductase	0.0016	0.0048	0.2553
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.223	1	1
Schistosoma mansoni	zinc finger protein	0.0007	0.0008	0.0007
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0048	0.0093
Onchocerca volvulus		0.0385	0.1707	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.001	0.002	0.0369
Giardia lamblia	Transcription regulatory protein SNF2	0.0006	0	0.0063
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0048	0.0048
Trichomonas vaginalis	bromodomain containing protein, putative	0.0006	0	0.0063
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0048	0.0912
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Leishmania major	trypanothione reductase	0.0047	0.0188	0.0365
Trypanosoma brucei	trypanothione reductase	0.0047	0.0188	0.0365
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0029	0.0106	0.4252
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0006	0	0.0063
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0081	0.0081
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.0076	0.4054
Schistosoma mansoni	CREB-binding protein 1 (SmCBP1)	0.0332	0.1467	0.1467
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0007	0.0006	0.0282
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	ferritin, putative	0.001	0.002	0.2664
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0486
Echinococcus granulosus	CREB binding protein	0.0054	0.0219	0.0219
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0048	0.2553
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.0461	0.8943
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0103	0.0103
Toxoplasma gondii	thioredoxin reductase	0.0047	0.0188	0.7554
Brugia malayi	PHD-finger family protein	0.0007	0.0008	0.0008
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0081	0.0081
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0006	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain and PHD finger-containing protein, putative	0.0006	0	0.0063
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0081	0.3115
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0108	0.0461	0.8934
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0048	0.1929
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0076	0.6553
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0486
Schistosoma mansoni	apoferritin-2	0.001	0.002	0.002
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0181	0.018
Giardia lamblia	Hypothetical protein	0.0006	0	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0385	0.1707	0.1707
Echinococcus granulosus	cpg binding protein	0.003	0.0111	0.0111
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0048	0.3267
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Onchocerca volvulus		0.0385	0.1707	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0181	0.018
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0048	0.6321
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0023	0.0076	0.9389
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0014	0.0014
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0007	0.0006
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0076	0.0148
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0006	0.0085
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0486
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0081	0.3115
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0188	0.0187
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0048	0.0093
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.0006	0.0005
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.005	0.0097
Echinococcus granulosus	CREB binding protein	0.0054	0.0219	0.0219
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0006	0.001
Schistosoma mansoni	ferritin	0.001	0.002	0.002
Echinococcus multilocularis	CREB binding protein	0.0228	0.0998	0.0998
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0048	0.2553
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0046	0.0182	0.0353
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.0516	1
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0006	0.001
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0006	0	0.0063
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0048	0.2553
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0181	0.0181
Trichomonas vaginalis	bromodomain containing protein, putative	0.0006	0	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0054	0.0054
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.1148	0.5136	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0006	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Schistosoma mansoni	ap endonuclease	0.0023	0.0076	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Leishmania major	hypothetical protein, conserved	0.0017	0.005	0.0097
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Giardia lamblia	Hypothetical protein	0.0006	0	0.0063
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.0076	0.0148
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0188	1
Leishmania major	C-8 sterol isomerase-like protein	0.1148	0.5136	1
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.001	0.002	0.0369
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0081	0.0081
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0006	0.001
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0048	0.0093
Echinococcus multilocularis	CREB binding protein	0.0054	0.0219	0.0219
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0029	0.0106	0.1964
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0048	0.1929
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0046	0.0182	0.9689
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0054	0.2874
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.0006	0.0213
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0181	0.018
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0046	0.0182	0.0353
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0188	1
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0006	0.0085
Chlamydia trachomatis	methionine aminopeptidase	0.0029	0.0106	1
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0006	0.0006
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0248	0.0248
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Leishmania major	acetyl-CoA synthetase, putative	0.0007	0.0006	0.001
Mycobacterium ulcerans	bacterioferritin BfrB	0.001	0.002	0.0601
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Onchocerca volvulus		0.0007	0.0006	0.0031
Schistosoma mansoni	bromodomain containing protein	0.0007	0.0008	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Echinococcus granulosus	ferritin	0.001	0.002	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0188	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Brugia malayi	glutathione reductase	0.0047	0.0188	0.0188
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0004	0.0486
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Brugia malayi	Thioredoxin reductase	0.0047	0.0188	0.0188
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.001	0.002	0.0286
Schistosoma mansoni	tyrosinase precursor	0.0385	0.1707	0.1707
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.0006	0.0005
Giardia lamblia	Kinase, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Onchocerca volvulus		0.0029	0.0104	0.0607
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0006	0.0085
Schistosoma mansoni	cpg binding protein	0.0029	0.0104	0.0104
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0029	0.0029
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.005	0.0944
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0081	0.1555
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0048	0.0093
Schistosoma mansoni	ferritin	0.001	0.002	0.002
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.223	1	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0008	0.0008
Schistosoma mansoni	tyrosinase precursor	0.0385	0.1707	0.1707
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0486
Onchocerca volvulus		0.0007	0.0006	0.0031
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0248	0.0248
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0046	0.0182	0.9689
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0048	0.0093
Trichomonas vaginalis	helicase, putative	0.0007	0.0004	0.0486
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0181	0.018
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0006	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trypanosoma brucei	RNA helicase, putative	0.0451	0.2003	0.39
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.0461	0.8943
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0048	0.0093
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0007	0.0006	0.0653
Trypanosoma brucei	C-8 sterol isomerase, putative	0.1148	0.5136	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.0076	0.0148
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0248	0.0483
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0046	0.0182	0.0353
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.0461	0.8943
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0048	0.0093
Echinococcus multilocularis	cpg binding protein	0.003	0.0111	0.0111
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0081	0.3115
Echinococcus granulosus	CREB binding protein	0.0332	0.1467	0.1467
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0248	0.0248
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0006	0.0006
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0054	0.2874
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0081	0.0158
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0081	0.3115
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0081	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0054	0.0054
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0048	0.0093
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0048	0.0048
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0029	0.0106	0.5629
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Echinococcus granulosus	expressed protein	0.001	0.002	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0014	0.0014
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.0461	0.8943
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0188	0.0187
Schistosoma mansoni	cpg binding protein	0.003	0.0111	0.0111
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.223	1	1
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0675	0.0675
Echinococcus multilocularis	CREB binding protein	0.0054	0.0219	0.0219
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0007	0.0006
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Plasmodium vivax	hypothetical protein, conserved	0.0017	0.005	0.2664
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0006	0.0006
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0181	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0486
Brugia malayi	Methionine aminopeptidase protein type I	0.0046	0.0182	0.0182
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0181	0.018
Loa Loa (eye worm)	hypothetical protein	0.1148	0.5136	0.5136
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0046	0.0182	0.0353
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0181	0.018
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0014	0.0014
Mycobacterium ulcerans	methionine aminopeptidase	0.0029	0.0106	0.4127
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0048	0.2553
Plasmodium falciparum	glutathione reductase	0.0047	0.0188	1
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0006	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0006	0.0754
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0081	0.0081
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Schistosoma mansoni	hypothetical protein	0.0451	0.2003	0.2003
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Echinococcus multilocularis	expressed protein	0.001	0.002	0.002
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0006	0.001
Trypanosoma brucei	methionine aminopeptidase, putative	0.0046	0.0182	0.0353
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0081	0.3115
Brugia malayi	Common central domain of tyrosinase family protein	0.0385	0.1707	0.1707
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Schistosoma mansoni	apoferritin-2	0.001	0.002	0.002
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Onchocerca volvulus		0.0385	0.1707	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Loa Loa (eye worm)	thioredoxin reductase	0.0047	0.0188	0.0188
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Plasmodium falciparum	HP12 protein homolog, putative	0.0017	0.005	0.2664
Onchocerca volvulus		0.0024	0.0081	0.0474
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0029	0.0106	0.1964
Brugia malayi	ShTK domain containing protein	0.0385	0.1707	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0587	0.2612	0.2612
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0047	0.0188	0.3625
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0006	0.0754
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0048	0.0048
Trichomonas vaginalis	bromodomain containing protein, putative	0.0006	0	0.0063
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0046	0.0182	0.0353
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Loa Loa (eye worm)	ShTK domain-containing protein	0.0385	0.1707	0.1707
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0006	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0006	0.0006
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0007	0.0008	0.0007
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0385	0.1707	0.1707
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0048	0.0093
Echinococcus granulosus	CREB binding protein	0.0205	0.0895	0.0895
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0029	0.0106	0.4127
Trichomonas vaginalis	bromodomain containing protein, putative	0.0006	0	0.0063
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.0461	0.8943
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0081	0.0081
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0104	0.0104
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Echinococcus granulosus	calcium activated potassium channel	0.0009	0.0015	0.0014
Entamoeba histolytica	ankyrin repeat protein, putative	0.0006	0	0.00000093048
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0188	0.0365
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0046	0.0182	0.0182
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0007	0.0006	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0054	0.0054
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0006	0.001
Schistosoma mansoni	ferritin light chain	0.001	0.002	0.002
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0006	0.0006
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0029	0.0106	0.5629
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0076	0.0076
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0006	0.0085
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0029	0.0106	0.0105
Trichomonas vaginalis	lymphoid specific helicase, putative	0.0006	0	0.0063
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0006	0	0.0063
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0023	0.0076	0.2911
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0048	0.0093
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0006	0.0085
Echinococcus granulosus	zinc finger protein	0.0007	0.0008	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Treponema pallidum	methionine aminopeptidase (map)	0.0029	0.0106	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0016	0.0048	0.3267
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Loa Loa (eye worm)	tyrosinase 1	0.0385	0.1707	0.1707
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0007	0.0008	0.0007
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0006	0.0085
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.005	0.0944
Toxoplasma gondii	hypothetical protein	0.0017	0.005	0.2013
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0054	0.1029
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0048	0.6321
Trichomonas vaginalis	bromodomain containing protein, putative	0.0006	0	0.0063
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0076	0.0076
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0016	0.0048	0.1753
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0486
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0486
Schistosoma mansoni	ferritin	0.001	0.002	0.002
Brugia malayi	TAZ zinc finger family protein	0.0332	0.1467	0.1467
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0081	0.1555
Onchocerca volvulus		0.0007	0.0006	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0048	0.0093
Schistosoma mansoni	bromodomain containing protein	0.0007	0.0008	0.0007
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0486
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0004	0.0486
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0054	0.1042
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0249	0.0249
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0081	0.1483
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0248	0.4805
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0029	0.0106	1
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.0076	0.6553
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0081	0.3115
Toxoplasma gondii	exonuclease III APE	0.0023	0.0076	0.3062
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.005	0.0944
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0248	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0081	0.0158
Trypanosoma brucei	hypothetical protein, conserved	0.0017	0.005	0.0097
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0248	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0081	0.1483
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0006	0.0085
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.1148	0.5136	0.5136
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.005	0.0944
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.0516	1
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0029	0.0106	0.0105
Schistosoma mansoni	cpg binding protein	0.003	0.0111	0.0111
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0385	0.1707	0.1707
Trichomonas vaginalis	bromodomain-containing protein 3, brd3, putative	0.0006	0	0.0063
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0006	0.0085
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.0516	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0054	0.2
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0029	0.0106	0.2033
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0004	0.0486
Plasmodium vivax	SET domain containing protein	0.0006	0.0003	0.0151
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0006	0	0.0063
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0006	0.0006
Echinococcus multilocularis	microtubule associated protein 2	0.0833	0.3721	0.372
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0054	0.0054
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.0006	0.0213
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0385	0.1707	0.1707
Schistosoma mansoni	serine/threonine protein kinase	0.223	1	1
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.0006	0.0213
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0023	0.0076	0.1459
Trichomonas vaginalis	histone acetyltransferase gcn5, putative	0.0006	0	0.0063
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0076	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0248	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0081	0.0081
Trichomonas vaginalis	ap endonuclease, putative	0.0023	0.0076	1
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0048	0.0093
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0081	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0081	0.0158
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0006	0.0085
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0006	0	0.0063
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0029	0.0029
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0076	0.0076
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.0516	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0048	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063
Schistosoma mansoni	microtubule-associated protein tau	0.0833	0.3721	0.372
Echinococcus multilocularis	ferritin	0.001	0.002	0.002
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0006	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0	0.0063

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (functional)	= 1.5849 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1436520

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1337890