Detailed information for compound 1352576

Basic information

Technical information
  • TDR Targets ID: 1352576
  • Name: 3-(4-chlorophenyl)-1-(4-sulfamoylphenyl)urea
  • MW: 325.771 | Formula: C13H12ClN3O3S
  • H donors: 3 H acceptors: 3 LogP: 1.68 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Cl)Nc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C13H12ClN3O3S/c14-9-1-3-10(4-2-9)16-13(18)17-11-5-7-12(8-6-11)21(15,19)20/h1-8H,(H2,15,19,20)(H2,16,17,18)
  • InChiKey: HACQCGHVZICZSC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00143531
  • 4-{[(4-chloroanilino)carbonyl]amino}benzenesulfonamide
  • MLS000704335
  • SMR000230984
  • ST040786
  • AI-204/31750036
  • ARONIS022559

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Homo sapiens carbonic anhydrase XII Starlite/ChEMBL References
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) References
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens carbonic anhydrase IX Starlite/ChEMBL References
Mycobacterium tuberculosis Beta-carbonic anhydrase References
Candida glabrata CBS 138 Carbonic anhydrase Starlite/ChEMBL References
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative Get druggable targets OG5_129533 All targets in OG5_129533
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB Get druggable targets OG5_127503 All targets in OG5_127503
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania infantum carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Mycobacterium tuberculosis Probable conserved transmembrane protein Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma congolense Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative Get druggable targets OG5_129533 All targets in OG5_129533
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_135410 All targets in OG5_135410
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_135410 All targets in OG5_135410
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium vivax sulfate transporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_129533 All targets in OG5_129533
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_129533 All targets in OG5_129533
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127503 All targets in OG5_127503
Theileria parva sulfate transporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Leishmania braziliensis carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative Get druggable targets OG5_129533 All targets in OG5_129533
Mycobacterium ulcerans integral membrane transporter Get druggable targets OG5_129533 All targets in OG5_129533
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Mycobacterium leprae Probable transmembrane transport protein Get druggable targets OG5_129533 All targets in OG5_129533
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium berghei inorganic anion antiporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Plasmodium knowlesi sulfate transporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Chlamydia trachomatis sulfate transporter Get druggable targets OG5_129533 All targets in OG5_129533
Candida albicans hypothetical protein Get druggable targets OG5_135410 All targets in OG5_135410
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) Get druggable targets OG5_129533 All targets in OG5_129533
Plasmodium yoelii sulfate permease family protein Get druggable targets OG5_129533 All targets in OG5_129533
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans Involved in protection against oxidative damage Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein Get druggable targets OG5_129533 All targets in OG5_129533
Leishmania donovani carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis Beta-carbonic anhydrase Get druggable targets OG5_135410 All targets in OG5_135410
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium ulcerans carbonic anhydrase Get druggable targets OG5_127503 All targets in OG5_127503
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_129533 All targets in OG5_129533
Leishmania major carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania mexicana carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans carbonic anhydrase Get druggable targets OG5_135410 All targets in OG5_135410
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans Involved in protection against oxidative damage Get druggable targets OG5_127503 All targets in OG5_127503
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter Get druggable targets OG5_129533 All targets in OG5_129533
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP Get druggable targets OG5_129533 All targets in OG5_129533
Babesia bovis sulfate transporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans hypothetical protein Get druggable targets OG5_135410 All targets in OG5_135410
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Entamoeba histolytica carbonic anhydrase, putative Get druggable targets OG5_127503 All targets in OG5_127503
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) Carbonic anhydrase   219 aa 199 aa 25.6 %
Trypanosoma cruzi carbonic anhydrase-like protein, putative carbonic anhydrase XII 354 aa 295 aa 23.1 %
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0021 0.0022
Trichomonas vaginalis protein transport protein sec7, putative 0.0009 0.0006 0.0006
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0134 0.0939 0.5248
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0016 0.006 0.0304
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0016 0.006 0.0152
Echinococcus granulosus SHC transforming protein 3 0.0016 0.006 0.0152
Echinococcus granulosus carbonic anhydrase 0.0134 0.0939 0.2588
Echinococcus granulosus dnaJ subfamily B 0.0494 0.3613 1
Echinococcus granulosus GPCR family 2 0.0019 0.0083 0.0215
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0016 0.006 0.0076
Brugia malayi protein-tyrosine kinase 0.0016 0.006 0.0304
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0032 0.0074
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0032 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0032 0.0074
Echinococcus granulosus pleckstrin y domain containing family A 0.0009 0.0006 0.0002
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0156 0.1103 0.0239
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0016 0.006 0.0152
Schistosoma mansoni tensin-related 0.0016 0.006 0.0152
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0917 0.0917
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0917 0.3758
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0009 0.0006 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0032 0.0074
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0205 0.0205
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0016 0.006 0.0076
Onchocerca volvulus 0.0016 0.006 0.0305
Schistosoma mansoni tyrosine kinase 0.0016 0.006 0.0152
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Brugia malayi SH2 domain containing protein 0.0016 0.006 0.0304
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.1784 0.493
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0016 0.006 0.0152
Schistosoma mansoni hypothetical protein 0.0016 0.006 0.0152
Loa Loa (eye worm) hypothetical protein 0.0041 0.0247 0.1357
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Brugia malayi Protein kinase domain containing protein 0.0016 0.006 0.0304
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0009 0.0006 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0205 0.0205
Schistosoma mansoni adapter molecule crk 0.0016 0.006 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Echinococcus multilocularis geminin 0.0205 0.1462 0.2019
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0009 0.0006 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0021 0.0044
Schistosoma mansoni hypothetical protein 0.0205 0.1462 0.4039
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.006 0.0152
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0032 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0083 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0032 0.0146
Echinococcus multilocularis tyrosine protein kinase Blk 0.0016 0.006 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0032 0.0146
Brugia malayi Variant SH3 domain containing protein 0.0016 0.006 0.0304
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0016 0.006 0.0076
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0032 0.0147
Brugia malayi Variant SH3 domain containing protein 0.0025 0.0125 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0134 0.0939 0.2588
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0939 0.5248
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0032 0.0147
Schistosoma mansoni GTPase activating protein 0.0016 0.006 0.0152
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0016 0.006 0.0223
Onchocerca volvulus 0.0016 0.006 0.0305
Schistosoma mansoni dynamin 0.0009 0.0006 0.0002
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0917 0.3758
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0032 0.0037
Echinococcus multilocularis N chimaerin 0.0016 0.006 0.0076
Echinococcus granulosus SH2 motif 0.0016 0.006 0.0152
Echinococcus multilocularis Pleckstrin y 0.0009 0.0006 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Echinococcus multilocularis growth factor receptor bound protein 2 0.0016 0.006 0.0076
Schistosoma mansoni zinc finger protein 0.0009 0.0006 0.0002
Brugia malayi hypothetical protein 0.0016 0.006 0.0304
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0016 0.006 0.0076
Entamoeba histolytica carbonic anhydrase, putative 0.0335 0.243 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0016 0.006 0.0305
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.006 0.0076
Schistosoma mansoni rho gtpase activating protein 0.0009 0.0006 0.0002
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0016 0.006 0.0076
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0032 0.0074
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0009 0.0006 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0083 0.0215
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0032 0.0074
Brugia malayi SRC-1 0.0016 0.006 0.0304
Onchocerca volvulus 0.0016 0.006 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0264 0.0718
Echinococcus granulosus Rho GTPase activating protein 24 0.0009 0.0006 0.0002
Echinococcus granulosus tyrosine protein kinase Src64B 0.0016 0.006 0.0152
Schistosoma mansoni syntrophin 0.0009 0.0006 0.0002
Entamoeba histolytica hypothetical protein 0.0043 0.0264 0.1065
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0205 0.2131
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.006 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0146
Schistosoma mansoni dynamin 0.0009 0.0006 0.0002
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0009 0.0006 0.0002
Schistosoma mansoni hypothetical protein 0.0041 0.0247 0.067
Schistosoma mansoni centaurin alpha 0.0009 0.0006 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0016 0.006 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Schistosoma mansoni goodpasture antigen-binding protein 0.0009 0.0006 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0032 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.1353 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.006 0.0152
Schistosoma mansoni goodpasture antigen-binding protein 0.0009 0.0006 0.0002
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0009 0.0006 0.0006
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.006 0.0152
Schistosoma mansoni hypothetical protein 0.0205 0.1462 0.4039
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0016 0.006 0.0152
Echinococcus multilocularis oxysterol binding protein 3 0.0009 0.0006 0.0001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0389 0.2153
Echinococcus granulosus geminin 0.0205 0.1462 0.4039
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus granulosus NCK adaptor protein 0.0016 0.006 0.0152
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.043 0.4541
Echinococcus granulosus tyrosine protein kinase Blk 0.0016 0.006 0.0152
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0032 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0917 0.0917
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0009 0.0006 0.0002
Echinococcus granulosus GRB2 associated binding protein 3 0.0009 0.0006 0.0002
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0205 0.082
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0939 0.5248
Echinococcus multilocularis pleckstrin y domain containing family A 0.0009 0.0006 0.0001
Echinococcus multilocularis NCK adaptor protein 0.0016 0.006 0.0076
Onchocerca volvulus 0.0016 0.006 0.0305
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0016 0.006 0.0152
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0248 0.1784 1
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0335 0.243 1
Brugia malayi SH2 domain containing protein 0.0016 0.006 0.0304
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0016 0.006 0.0076
Leishmania major carbonic anhydrase family protein, putative 0.0335 0.243 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Echinococcus granulosus SH2 domain containing protein 7 0.0016 0.006 0.0152
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.7219 1
Brugia malayi Protein kinase domain containing protein 0.0016 0.006 0.0304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0032 0.0146
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0016 0.006 0.0223
Echinococcus multilocularis SH2 motif 0.0016 0.006 0.0076
Brugia malayi SH2 domain containing protein 0.0016 0.006 0.0304
Echinococcus multilocularis Rho GTPase activating protein 24 0.0009 0.0006 0.0001
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0939 0.1294
Echinococcus granulosus suppressor of cytokine signaling 6 0.0016 0.006 0.0152
Echinococcus granulosus pdz domain containing protein 0.0009 0.0006 0.0002
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0032 0.0074
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0248 0.1784 0.493
Echinococcus multilocularis SH2 motif 0.0016 0.006 0.0076
Brugia malayi SH2 domain containing protein 0.0016 0.006 0.0304
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.0917 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0016 0.006 0.0152
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0917 0.0917
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0016 0.006 0.0152
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0032 0.0074
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0025 0.0125 0.0668
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0917 0.5124
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0917 0.5124
Schistosoma mansoni tyrosine kinase 0.0016 0.006 0.0152
Schistosoma mansoni hypothetical protein 0.0016 0.006 0.0152
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0032 0.0146
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.006 0.0152
Schistosoma mansoni cpg binding protein 0.0037 0.0214 0.0578
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0009 0.0006 0.0006
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0009 0.0006 0.0002
Echinococcus multilocularis oxysterol binding protein 1 0.0009 0.0006 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Schistosoma mansoni cpg binding protein 0.0037 0.0214 0.0578
Loa Loa (eye worm) hypothetical protein 0.0134 0.0939 0.5248
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.006 0.0076
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0032 0.0074
Onchocerca volvulus 0.0016 0.006 0.0305
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0146
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0016 0.006 0.0305
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0016 0.006 0.0076
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0039 0.0234 0.1279
Echinococcus granulosus c src tyrosine kinase 0.0016 0.006 0.0152
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.0917 0.5124
Onchocerca volvulus 0.0016 0.006 0.0305
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Echinococcus granulosus expressed conserved protein 0.0016 0.006 0.0152
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0016 0.006 0.0152
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0016 0.006 0.0304
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0032 0.0074
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0939 0.1294
Echinococcus granulosus carbonic anhydrase 0.0134 0.0939 0.2588
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0009 0.0006 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.006 0.0304
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0205 0.8749
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.0917 0.3758
Echinococcus granulosus oxysterol binding protein 3 0.0009 0.0006 0.0002
Loa Loa (eye worm) SH2 domain-containing protein 0.0016 0.006 0.0304
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0032 0.0146
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.006 0.0076
Schistosoma mansoni carbonic anhydrase 0.0134 0.0939 0.2588
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0009 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0432
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0205 0.0205
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0939 0.2588
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0032 0.0037
Echinococcus multilocularis myotubularin protein 13 0.0009 0.0006 0.0001
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0039 0.0234 0.2436
Brugia malayi 6-phosphofructokinase 0.0131 0.0917 0.5124
Plasmodium vivax sulfate transporter, putative 0.0039 0.0234 1
Loa Loa (eye worm) phosphofructokinase 0.0131 0.0917 0.5124
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0032 0.0146
Echinococcus granulosus tyrosine protein kinase Lyn 0.0016 0.006 0.0152
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0389 0.2153
Brugia malayi Sex muscle abnormal protein 5 0.0016 0.006 0.0304
Echinococcus granulosus tyrosine kinase 0.0016 0.006 0.0152
Echinococcus granulosus tyrosine protein kinase ABL1 0.0016 0.006 0.0152
Loa Loa (eye worm) SH2 domain-containing protein 0.0016 0.006 0.0304
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0032 0.0074
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0205 0.5
Onchocerca volvulus Putative sulfate transporter 0.0247 0.1775 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0199 0.1086
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0205 0.0205
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0247 0.1357
Toxoplasma gondii hypothetical protein 0.0134 0.0939 1
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0009 0.0006 0.0001
Echinococcus granulosus SH2 domain containing adapter protein F 0.0016 0.006 0.0152
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0083 0.0107
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0146
Echinococcus multilocularis carbonic anhydrase II 0.0248 0.1784 0.2465
Echinococcus multilocularis beta 1 syntrophin 0.0009 0.0006 0.0001
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1175 0.8673 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0032 0.0146
Schistosoma mansoni hypothetical protein 0.0019 0.0083 0.0215
Brugia malayi Protein kinase domain containing protein 0.0016 0.006 0.0304
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0032 0.0074
Trichomonas vaginalis protein transport protein sec7, putative 0.0009 0.0006 0.0006
Echinococcus multilocularis SH2 motif 0.0016 0.006 0.0076
Brugia malayi RhoGAP domain containing protein 0.0016 0.006 0.0304
Brugia malayi phosphofructokinase 0.0131 0.0917 0.5124
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.0939 0.5248
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0016 0.006 0.0076
Onchocerca volvulus 0.0012 0.0032 0.0147
Schistosoma mansoni coup transcription factor 0.0012 0.0032 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0032 0.0146
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.006 0.0152
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0205 0.2131
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0146
Schistosoma mansoni hypothetical protein 0.0019 0.0083 0.0215
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0146
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus granulosus cytohesin 1 0.0009 0.0006 0.0002
Echinococcus multilocularis Pleckstrin y 0.0009 0.0006 0.0001
Onchocerca volvulus 0.0016 0.006 0.0305
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.002 0.0079
Trypanosoma brucei carbonic anhydrase-like protein 0.0248 0.1784 1
Trichomonas vaginalis conserved hypothetical protein 0.1353 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0032 0.0146
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0083 0.0215
Echinococcus multilocularis GPCR, family 2 0.0019 0.0083 0.0107
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0032 0.0074
Schistosoma mansoni tyrosine kinase 0.0016 0.006 0.0152
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0032 0.0074
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.006 0.0076
Onchocerca volvulus 0.0247 0.1775 1
Echinococcus multilocularis 0.0016 0.006 0.0076
Schistosoma mansoni serine/threonine-protein kinase 0.0009 0.0006 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Echinococcus granulosus tyrosine protein kinase Srms 0.0016 0.006 0.0152
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Brugia malayi STAT protein, DNA binding domain containing protein 0.0016 0.006 0.0304
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0146
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Loa Loa (eye worm) carbonic anhydrase 3 0.0248 0.1784 1
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0009 0.0006 0.0002
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0264 0.0718
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus multilocularis tyrosine protein kinase Srms 0.0016 0.006 0.0076
Echinococcus granulosus serine/threonine protein kinase 0.0009 0.0006 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0248 0.1784 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0016 0.006 0.0152
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Entamoeba histolytica hypothetical protein 0.0043 0.0264 0.1065
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0134 0.0939 0.5248
Brugia malayi Tensin 0.0016 0.006 0.0304
Echinococcus multilocularis SH2 domain containing protein 7 0.0016 0.006 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0248 0.1784 1
Echinococcus multilocularis SHC transforming protein 3 0.0016 0.006 0.0076
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0285 0.2059 0.1472
Schistosoma mansoni growth factor receptor-bound protein 0.0009 0.0006 0.0002
Echinococcus granulosus SH2 motif 0.0016 0.006 0.0152
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0032 0.0037
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0205 0.2131
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0463 0.3386 0.3183
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.1784 1
Echinococcus multilocularis signal transduction protein lnk realted 0.0016 0.006 0.0076
Loa Loa (eye worm) SRC-1 0.0016 0.006 0.0304
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0009 0.0006 0.0001
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0032 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0009 0.0006 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus multilocularis rac serine:threonine kinase 0.0009 0.0006 0.0001
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0002
Mycobacterium leprae Probable transmembrane transport protein 0.0285 0.2059 0.7547
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Onchocerca volvulus 0.0016 0.006 0.0305
Loa Loa (eye worm) hypothetical protein 0.0134 0.0939 0.5248
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0009 0.0006 0.0001
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.006 0.0152
Echinococcus multilocularis GRB2 associated binding protein 3 0.0009 0.0006 0.0001
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0205 0.0205
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0205 0.0205
Echinococcus multilocularis Oxysterol binding protein 11 0.0009 0.0006 0.0001
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0016 0.006 0.0304
Echinococcus granulosus N chimaerin 0.0016 0.006 0.0152
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0032 0.0074
Mycobacterium ulcerans carbonic anhydrase 0.0335 0.243 0.2249
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0248 0.1784 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0032 0.0146
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0205 0.8749
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0032 0.0146
Entamoeba histolytica hypothetical protein 0.0043 0.0264 0.1065
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0009 0.0006 0.0001
Brugia malayi Tyrosine-protein kinase abl-1 0.0016 0.006 0.0304
Echinococcus granulosus hypothetical protein 0.0016 0.006 0.0152
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0205 0.0205
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.0917 0.3758
Schistosoma mansoni hypothetical protein 0.0019 0.0083 0.0215
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0002
Brugia malayi hypothetical protein 0.0016 0.006 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0032 0.0146
Entamoeba histolytica hypothetical protein 0.0043 0.0264 0.1065
Trichomonas vaginalis kinesin light chain, putative 0.0009 0.0006 0.0006
Echinococcus multilocularis tensin 0.0016 0.006 0.0076
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0917 0.2527
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0032 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0032 0.0146
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0016 0.006 0.0304
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0032 0.0146
Echinococcus multilocularis cytohesin 1 0.0009 0.0006 0.0001
Plasmodium falciparum carbonic anhydrase 0.0134 0.0939 1
Echinococcus granulosus myotubularin protein 13 0.0009 0.0006 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0032 0.0146
Brugia malayi SH2 domain containing protein 0.0016 0.006 0.0304
Loa Loa (eye worm) hypothetical protein 0.006 0.0389 0.2153
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0083 0.0107
Echinococcus multilocularis calcium dependent secretion activator 1 0.0009 0.0006 0.0001
Onchocerca volvulus 0.0035 0.0199 0.1092
Schistosoma mansoni carbonic anhydrase 0.0335 0.243 0.6721
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0205 0.2131
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0032 0.0037
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0016 0.006 0.0076
Trichomonas vaginalis centaurin alpha, putative 0.0009 0.0006 0.0006
Echinococcus granulosus beta 1 syntrophin 0.0009 0.0006 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0389 0.2153
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Brugia malayi Protein kinase domain containing protein 0.0016 0.006 0.0304
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0009 0.0006 0.0006
Entamoeba histolytica SH2 domain containing protein 0.0016 0.006 0.0223
Brugia malayi ecdysteroid receptor 0.0012 0.0032 0.0146
Brugia malayi 6-phosphofructokinase 0.0131 0.0917 0.5124
Loa Loa (eye worm) TK protein kinase 0.0016 0.006 0.0304
Schistosoma mansoni nck2/grb4 0.0016 0.006 0.0152
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Echinococcus granulosus oxysterol binding protein 9 0.0009 0.0006 0.0002
Echinococcus granulosus suppressor of cytokine signaling 7 0.0016 0.006 0.0152
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0016 0.006 0.0076
Schistosoma mansoni tensin 0.0016 0.006 0.0152
Echinococcus granulosus tensin 0.0016 0.006 0.0152
Schistosoma mansoni suppressor of cytokine signaling 0.0016 0.006 0.0152
Loa Loa (eye worm) STAT protein 0.0016 0.006 0.0304
Schistosoma mansoni vav2 0.0025 0.0125 0.0331
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0016 0.006 0.0304
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0009 0.0006 0.0002
Echinococcus multilocularis actin binding protein anillin 0.0009 0.0006 0.0001
Schistosoma mansoni suppressor of cytokine signaling 0.0016 0.006 0.0152
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0009 0.0006 0.0001
Echinococcus granulosus tyrosine protein kinase shark 0.0016 0.006 0.0152
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0032 0.0037
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0032 0.0146
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0016 0.006 0.0152
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0009 0.0006 0.0001
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0016 0.006 0.0076
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0016 0.006 0.0076
Trichomonas vaginalis alpha chimerin, putative 0.0009 0.0006 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0032 0.0074
Brugia malayi Variant SH3 domain containing protein 0.0016 0.006 0.0304
Echinococcus multilocularis tyrosine protein kinase Abl 0.0016 0.006 0.0076
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0021 0.0085
Entamoeba histolytica protein kinase, putative 0.0016 0.006 0.0223
Schistosoma mansoni hypothetical protein 0.0043 0.0264 0.0718
Echinococcus multilocularis cpg binding protein 0.0037 0.0214 0.0289
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0134 0.0939 0.5248
Trichomonas vaginalis centaurin/arf, putative 0.0009 0.0006 0.0006
Brugia malayi Protein kinase domain containing protein 0.0016 0.006 0.0304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0032 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0032 0.0146
Schistosoma mansoni tensin 0.0016 0.006 0.0152
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.0917 0.1264
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0016 0.006 0.0076
Schistosoma mansoni shc transforming protein 0.0016 0.006 0.0152
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0032 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0032 0.0146
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0939 0.2588
Schistosoma mansoni hypothetical protein 0.0009 0.0006 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0032 0.0074
Trichomonas vaginalis centaurin/arf, putative 0.0009 0.0006 0.0006
Onchocerca volvulus 0.0016 0.006 0.0305
Onchocerca volvulus 0.0016 0.006 0.0305
Echinococcus granulosus dynamin 1 0.0009 0.0006 0.0002
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0083 0.0432
Echinococcus granulosus Pleckstrin y 0.0009 0.0006 0.0002
Schistosoma mansoni zinc finger protein 0.0009 0.0006 0.0002
Brugia malayi cytokine inducible SH2-containing protein 5 0.0016 0.006 0.0304
Echinococcus multilocularis DCC interacting protein 13 beta 0.0009 0.0006 0.0001
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0032 0.0147
Schistosoma mansoni carbonic anhydrase-related 0.0134 0.0939 0.2588
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0032 0.0146
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0083 0.0432
Brugia malayi nuclear receptor NHR-88 0.0012 0.0032 0.0146
Brugia malayi SH2 domain containing protein 0.0016 0.006 0.0304
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0039 0.0234 0.1279
Schistosoma mansoni SH2A 0.0016 0.006 0.0152
Brugia malayi SH2 domain containing protein 0.0016 0.006 0.0304
Echinococcus granulosus signal transduction protein lnk realted 0.0016 0.006 0.0152
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.0917 0.2527
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0016 0.006 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.006 0.0076
Echinococcus multilocularis tyrosine kinase 0.0016 0.006 0.0076
Schistosoma mansoni tyrosine kinase 0.0016 0.006 0.0152
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Brugia malayi hypothetical protein 0.0043 0.0264 0.1453
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0032 0.0146
Onchocerca volvulus 0.0016 0.006 0.0305
Echinococcus granulosus cpg binding protein 0.0037 0.0214 0.0578
Echinococcus granulosus Pleckstrin y 0.0009 0.0006 0.0002
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0016 0.006 0.0152
Brugia malayi Variant SH3 domain containing protein 0.0016 0.006 0.0304
Echinococcus multilocularis tensin 0.0016 0.006 0.0076
Schistosoma mansoni cpg binding protein 0.0035 0.0199 0.0537
Loa Loa (eye worm) TK/ABL protein kinase 0.0016 0.006 0.0304
Schistosoma mansoni tensin 0.0016 0.006 0.0152
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0016 0.006 0.0152
Chlamydia trachomatis sulfate transporter 0.0039 0.0234 1
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0146
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0039 0.0234 0.2436
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0199 0.1086
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0032 0.0074
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0032 0.0037
Onchocerca volvulus 0.0016 0.006 0.0305
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0016 0.006 0.0152
Trichomonas vaginalis hypothetical protein 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0134 0.0939 0.5248
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0032 0.0146
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0264 0.0359
Loa Loa (eye worm) TK/FER protein kinase 0.0016 0.006 0.0304
Schistosoma mansoni tyrosine kinase 0.0016 0.006 0.0152
Echinococcus multilocularis carbonic anhydrase 0.0134 0.0939 0.1294
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0488 0.1338
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0009 0.0006 0.0002
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0009 0.0006 0.0002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0016 0.006 0.0152
Brugia malayi nuclear hormone receptor 0.0012 0.0032 0.0146
Schistosoma mansoni tensin-related 0.0016 0.006 0.0152
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0016 0.006 0.0076
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.0917 0.5124
Brugia malayi SH2 domain containing protein 0.0016 0.006 0.0304
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0205 0.2131
Echinococcus granulosus carbonic anhydrase II 0.0248 0.1784 0.493
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0016 0.006 0.0152
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0032 0.0146
Schistosoma mansoni tyrosine kinase 0.0016 0.006 0.0152
Trichomonas vaginalis centaurin beta, putative 0.0009 0.0006 0.0006
Echinococcus granulosus calcium dependent secretion activator 1 0.0009 0.0006 0.0002
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.006 0.0076
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.0917 0.0917
Echinococcus multilocularis Pleckstrin y 0.0009 0.0006 0.0001
Echinococcus granulosus tyrosine kinase 0.0016 0.006 0.0152
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.0917 0.2527
Echinococcus granulosus oxysterol binding protein 1 0.0009 0.0006 0.0002
Echinococcus granulosus DCC interacting protein 13 beta 0.0009 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Schistosoma mansoni oxysterol-binding protein 1 0.0009 0.0006 0.0002
Loa Loa (eye worm) SH2 domain-containing protein 0.0016 0.006 0.0304
Brugia malayi SH2 domain containing protein 0.0016 0.006 0.0304
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0009 0.0006 0.0006
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Brugia malayi steroid hormone receptor 0.0012 0.0032 0.0146
Echinococcus multilocularis Ras associated and pleckstrin y 0.0009 0.0006 0.0001
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0006 0.0006
Echinococcus granulosus Pleckstrin y 0.0009 0.0006 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0146
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0009 0.0006 0.0002
Schistosoma mansoni signal transduction protein lnk-related 0.0016 0.006 0.0152
Schistosoma mansoni hypothetical protein 0.0494 0.3613 1
Schistosoma mansoni oxysterol-binding protein 1 0.0009 0.0006 0.0002
Echinococcus granulosus tyrosine protein kinase Src42A 0.0016 0.006 0.0152
Echinococcus multilocularis dynamin 1 0.0009 0.0006 0.0001
Trichomonas vaginalis centaurin gamma, putative 0.0009 0.0006 0.0006
Echinococcus granulosus carbonic anhydrase 0.0134 0.0939 0.2588
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0016 0.006 0.0076
Schistosoma mansoni serine/threonine-protein kinase 0.0009 0.0006 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.3613 0.5
Schistosoma mansoni hypothetical protein 0.0019 0.0083 0.0215
Loa Loa (eye worm) hypothetical protein 0.0025 0.0125 0.0668
Loa Loa (eye worm) hypothetical protein 0.0016 0.006 0.0304
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0009 0.0006 0.0006
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0039 0.0234 0.1279
Brugia malayi tRNA modification GTPase TrmE family protein 0.0016 0.006 0.0304
Echinococcus multilocularis pdz domain containing protein 0.0009 0.0006 0.0001
Echinococcus multilocularis tyrosine protein kinase shark 0.0016 0.006 0.0076
Echinococcus granulosus Oxysterol binding protein 11 0.0009 0.0006 0.0002
Leishmania major carbonic anhydrase-like protein 0.0248 0.1784 0.7334
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.0917 0.07
Schistosoma mansoni myotubularin-related protein 0.0009 0.0006 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0006 0.0006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0032 0.0074
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0016 0.006 0.0152
Echinococcus multilocularis oxysterol binding protein 9 0.0009 0.0006 0.0001

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4.8 nM Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay ChEMBL. 21145236
Ki (binding) = 5.3 nM Inhibition of tumor-associated human carbonic anhydrase 12 preincubated for 15 min by CO2 hydration assay ChEMBL. 21361354
Ki (binding) = 7 nM Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay ChEMBL. 23511020
Ki (binding) = 58 nM Inhibition of tumor-associated human carbonic anhydrase 9 preincubated for 15 min by CO2 hydration assay ChEMBL. 21361354
Ki (binding) = 63.1 nM Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv3273 preincubated for 15 mins by stopped-flow CO2 hydrase assay ChEMBL. 21145236
Ki (binding) = 781 nM Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay ChEMBL. 21145236
Ki (binding) = 781 nM Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 min by CO2 hydration assay ChEMBL. 21361354
Ki (binding) = 2150 nM Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 min by CO2 hydration assay ChEMBL. 21361354
Potency (functional) 6.012 uM PUBCHEM_BIOASSAY: Tb PFK orthogonal confirmatory assay using ATP depletion (Kinase-Glo Plus) as an alternative measure of Tb PFK activity: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.3183 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10.3225 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10.691 uM PUBCHEM_BIOASSAY: Inhibitors of T. brucei phosphofructokinase: Hit Validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768] ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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