TDR Targets

Basic information

Technical information

TDR Targets ID: 1367691
Name: 2-[(Z)-2-(1,3-benzodioxol-5-yl)ethenyl]quinol ine
MW: 275.301 | Formula: C18H13NO2
H donors: 0 H acceptors: 1 LogP: 4.31 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: C1Oc2c(O1)cc(cc2)/C=C\c1ccc2c(n1)cccc2
InChi: 1S/C18H13NO2/c1-2-4-16-14(3-1)7-9-15(19-16)8-5-13-6-10-17-18(11-13)21-12-20-17/h1-11H,12H2/b8-5-
InChiKey: WCTKZIWXPMEAHC-YVMONPNESA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[(Z)-2-(1,3-benzodioxol-5-yl)vinyl]quinoline
ZINC04532200
2-((Z)-2-Benzo[1,3]dioxol-5-yl-vinyl)-quinoline
BAS 04056242
ST5274028

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	alpha-glucosidase, putative	0.0116	0.0299	0.1595
Echinococcus granulosus	importin subunit beta 1	0.0026	0.0005	0.001
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0116	0.0299	0.0724
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0123	0.0322	0.3896
Schistosoma mansoni	hypothetical protein	0.003	0.0018	0.0037
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0265	0.079	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0353	0.0857
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.003	0.0018	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0232	0.0559
Brugia malayi	Trehalase family protein	0.0132	0.0353	0.0857
Loa Loa (eye worm)	trehalase	0.0132	0.0353	0.0857
Echinococcus granulosus	ubiquitin specific protease 41	0.0105	0.0264	0.0507
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0098	0.0242	0.0705
Brugia malayi	hypothetical protein	0.0046	0.007	0.0163
Trypanosoma cruzi	hypothetical protein, conserved	0.0159	0.0442	0.5457
Schistosoma mansoni	alpha-glucosidase	0.0722	0.2288	0.5591
Schistosoma mansoni	hypothetical protein	0.0183	0.0518	0.126
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0442	0.1073
Schistosoma mansoni	ap endonuclease	0.0034	0.0032	0.0071
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0032	0.0024	0.0173
Trichomonas vaginalis	conserved hypothetical protein	0.0132	0.0353	0.1908
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0109	0.0278	0.6176
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0034	0.0032	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0046	0.007	0.0163
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0558	0.1749	1
Plasmodium vivax	importin-beta 2, putative	0.0026	0.0005	0.0046
Trichomonas vaginalis	beta-glucosidase, putative	0.0267	0.0796	0.4475
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0098	0.0242	0.5336
Echinococcus multilocularis	microtubule associated protein 2	0.1263	0.406	0.4058
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0105	0.0264	0.0261
Onchocerca volvulus	Huntingtin homolog	0.0108	0.0275	0.1276
Loa Loa (eye worm)	trehalase	0.0132	0.0353	0.0857
Loa Loa (eye worm)	glutathione reductase	0.0043	0.0061	0.0141
Echinococcus multilocularis	neuropeptide s receptor	0.092	0.2937	0.2935
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.0459	0.2142
Plasmodium vivax	hypothetical protein, conserved	0.0086	0.0201	0.4508
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0123	0.0322	0.4043
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0742	0.4164
Brugia malayi	beta-lactamase	0.0159	0.0442	0.1073
Brugia malayi	hypothetical protein	0.0132	0.0353	0.0857
Plasmodium falciparum	glutathione reductase	0.0043	0.0061	0.2838
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0264	0.0638
Toxoplasma gondii	thioredoxin reductase	0.0043	0.0061	0.0475
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0105	0.0264	0.0507
Loa Loa (eye worm)	trehalase	0.0046	0.007	0.0163
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0558	0.1749	1
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0841	0.2678	0.6544
Echinococcus granulosus	beta mannosidase	0.0077	0.0171	0.0329
Trichomonas vaginalis	alpha-glucosidase, putative	0.0116	0.0299	0.1595
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0034	0.0032	0.1371
Schistosoma mansoni	aldehyde dehydrogenase	0.0395	0.1214	0.2964
Echinococcus granulosus	neuropeptide s receptor	0.092	0.2937	0.5649
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0442	0.1073
Trichomonas vaginalis	penicillin-binding protein, putative	0.0159	0.0442	0.2422
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0037	0.0039	0.0195
Schistosoma mansoni	inositol monophosphatase	0.0032	0.0024	0.0051
Leishmania major	hypothetical protein, conserved	0.005	0.0084	0.0501
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0116	0.0299	0.3593
Brugia malayi	Trehalase protein 5	0.0046	0.007	0.0163
Brugia malayi	trehalase I	0.0046	0.007	0.0163
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0395	0.1214	0.2336
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0098	0.0242	0.0705
Mycobacterium ulcerans	esterase/lipase LipP	0.0159	0.0442	0.0807
Echinococcus multilocularis	GPCR, family 2	0.003	0.0018	0.0015
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0116	0.0299	0.1595
Echinococcus multilocularis	thyroid hormone receptor alpha	0.014	0.0377	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0442	0.1073
Echinococcus granulosus	beta galactosidase	0.0281	0.0841	0.1618
Toxoplasma gondii	ABC1 family protein	0.0159	0.0442	0.3622
Trichomonas vaginalis	trehalase, putative	0.0132	0.0353	0.1908
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0105	0.0264	0.0261
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0159	0.0442	0.1073
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.028	0.0836	0.2038
Echinococcus granulosus	neutral alpha glucosidase AB	0.0265	0.079	0.1519
Mycobacterium tuberculosis	Probable esterase LipL	0.0159	0.0442	0.1321
Schistosoma mansoni	hypothetical protein	0.003	0.0018	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0442	0.1073
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0084	0.0779
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0275	0.0665
Schistosoma mansoni	microtubule-associated protein tau	0.1263	0.406	0.9925
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0459	0.2523
Trichomonas vaginalis	D-aminoacylase, putative	0.0159	0.0442	0.2422
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0159	0.0442	0.1073
Brugia malayi	Trehalase family protein	0.0132	0.0353	0.0857
Echinococcus granulosus	histone lysine methyltransferase setb	0.0026	0.0003	0.0006
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0459	0.2523
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0459	0.2523
Loa Loa (eye worm)	hypothetical protein	0.003	0.0018	0.0037
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0395	0.1214	0.23
Echinococcus granulosus	beta LACTamase domain containing family member	0.0159	0.0442	0.085
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0034	0.0032	0.0103
Trypanosoma cruzi	hypothetical protein, conserved	0.0265	0.079	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0203	0.0489
Brugia malayi	hypothetical protein	0.0046	0.007	0.0163
Loa Loa (eye worm)	beta-glucuronidase	0.0106	0.0268	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0353	0.0857
Echinococcus multilocularis	importin subunit beta 1	0.0026	0.0005	0.0002
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0116	0.0299	0.3593
Schistosoma mansoni	thyroid hormone receptor	0.014	0.0377	0.0915
Echinococcus multilocularis	ubiquitin specific protease 41	0.0105	0.0264	0.0261
Onchocerca volvulus		0.0675	0.2134	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0043	0.0061	0.0478
Schistosoma mansoni	ap endonuclease	0.0034	0.0032	0.0071
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.003	0.0018	0.0015
Trichomonas vaginalis	esterase, putative	0.0159	0.0442	0.2422
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0098	0.0242	0.0705
Trichomonas vaginalis	alpha-glucosidase, putative	0.0265	0.079	0.4438
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0159	0.0442	0.1073
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0034	0.0032	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0281	0.0841	0.205
Brugia malayi	glutathione reductase	0.0043	0.0061	0.0141
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0159	0.0442	0.0439
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0105	0.0264	0.0507
Echinococcus multilocularis	beta galactosidase	0.0281	0.0841	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0046	0.007	0.0163
Brugia malayi	Trehalase family protein	0.0046	0.007	0.0163
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0105	0.0264	0.313
Trichomonas vaginalis	alpha-glucosidase, putative	0.0265	0.079	0.4438
Brugia malayi	manba-prov protein	0.0183	0.052	0.1264
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0105	0.0264	0.1389
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.003	0.0018	0.0035
Trypanosoma brucei	hypothetical protein, conserved	0.0159	0.0442	0.5567
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0084	0.4016
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.003	0.0018	0.0035
Brugia malayi	Trehalase family protein	0.0046	0.007	0.0163
Trichomonas vaginalis	beta-mannosidase, putative	0.0077	0.0171	0.0853
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0395	0.1214	0.23
Echinococcus granulosus	GPCR family 2	0.003	0.0018	0.0035
Brugia malayi	Alpha-L-fucosidase family protein	0.1272	0.4091	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0395	0.1214	1
Schistosoma mansoni	hypothetical protein	0.028	0.0836	0.2038
Loa Loa (eye worm)	MH2 domain-containing protein	0.0106	0.0267	0.0646
Mycobacterium tuberculosis	Conserved protein	0.0159	0.0442	0.1321
Onchocerca volvulus		0.0089	0.0212	0.0981
Loa Loa (eye worm)	glycosyl hydrolase family 2	0.0115	0.0297	0.0719
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0105	0.0264	0.0638
Loa Loa (eye worm)	alpha-L-fucosidase	0.1272	0.4091	1
Plasmodium vivax	thioredoxin reductase, putative	0.0043	0.0061	0.1313
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.026	0.0771	0.9756
Brugia malayi	Trehalase family protein	0.0132	0.0353	0.0857
Mycobacterium leprae	Probable lipase LipE	0.0159	0.0442	1
Onchocerca volvulus		0.0159	0.0442	0.2059
Brugia malayi	hypothetical protein	0.005	0.0084	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0299	0.0724
Loa Loa (eye worm)	hypothetical protein	0.0046	0.007	0.0163
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0395	0.1214	0.1212
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0034	0.0032	0.0658
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0395	0.1214	0.3702
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0212	0.0511
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0116	0.0299	0.3748
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0841	0.2678	0.2675
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0116	0.0299	0.1595
Trichomonas vaginalis	penicillin-binding protein, putative	0.0159	0.0442	0.2422
Brugia malayi	Glycosyl hydrolases family 2, sugar binding domain containing protein	0.0115	0.0297	0.0719
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0265	0.079	0.4438
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0459	0.2523
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0105	0.0264	0.0638
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.0488	0.2692
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0129	0.0343	0.034
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0037	0.0039	0.0432
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0116	0.0299	0.1595
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.003	0.0018	0.0037
Echinococcus granulosus	microtubule associated protein 2	0.1263	0.406	0.7808
Schistosoma mansoni	hypothetical protein	0.0115	0.0297	0.0719
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0084	0.0666
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0061	0.0058
Trichomonas vaginalis	beta-galactosidase, putative	0.0221	0.0646	0.3603
Schistosoma mansoni	importin beta-1	0.0026	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0032	0.0025	0.0055
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.026	0.0771	0.9762
Onchocerca volvulus		0.0203	0.0585	0.273
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0105	0.0264	1
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0105	0.0264	0.2013
Loa Loa (eye worm)	hypothetical protein	0.0281	0.0841	0.205
Mycobacterium tuberculosis	Probable dehydrogenase	0.0098	0.0242	0.0705
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0265	0.079	0.1924
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0137	0.0368	0.1093
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0264	0.1389
Echinococcus multilocularis	beta mannosidase	0.0077	0.0171	0.0168
Entamoeba histolytica	beta-galactosidase, putative	0.0115	0.0297	0.3564
Echinococcus granulosus	snurportin 1	0.028	0.0836	0.1608
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0061	0.0117
Trichomonas vaginalis	glucosylceramidase, putative	0.0174	0.0488	0.2692
Trypanosoma brucei	glucosidase, putative	0.0265	0.079	1
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0235	0.0688	0.8677
Mycobacterium tuberculosis	Conserved protein	0.0159	0.0442	0.1321
Brugia malayi	beta-lactamase family protein	0.0159	0.0442	0.1073
Mycobacterium tuberculosis	Probable oxidoreductase	0.0109	0.0278	0.0816
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0265	0.079	1
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0353	0.0857
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.026	0.0771	0.9756
Leishmania major	mitochondrial DNA polymerase beta	0.026	0.0771	0.6275
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0133	0.0318
Schistosoma mansoni	beta-mannosidase	0.0077	0.0171	0.0411
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0086	0.0201	1
Loa Loa (eye worm)	TRE-2 protein	0.0132	0.0353	0.0857
Brugia malayi	Pre-SET motif family protein	0.0178	0.0504	0.1225
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0159	0.0442	0.1321
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0742	0.4164
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0265	0.079	0.6494
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0034	0.0032	0.0015
Mycobacterium tuberculosis	Conserved protein	0.0159	0.0442	0.1321
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0095	0.0232	0.0559
Leishmania major	glycosyl hydrolase-like protein	0.0116	0.0299	0.2311
Trichomonas vaginalis	ap endonuclease, putative	0.0034	0.0032	0.0046
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0178	0.0504	0.1225
Brugia malayi	Thioredoxin reductase	0.0043	0.0061	0.0141
Trypanosoma cruzi	hypothetical protein, conserved	0.0159	0.0442	0.5457
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0105	0.0264	0.313
Schistosoma mansoni	alpha-glucosidase	0.0722	0.2288	0.5591
Schistosoma mansoni	alpha-l-fucosidase	0.1272	0.4091	1
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0442	0.1073
Onchocerca volvulus		0.0132	0.0353	0.1643
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0037	0.0039	0.0195
Trichomonas vaginalis	alpha-glucosidase, putative	0.0265	0.079	0.4438
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0045	0.0065	0.0537
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0084	0.1002
Trichomonas vaginalis	set domain proteins, putative	0.0203	0.0585	0.3249
Onchocerca volvulus		0.0132	0.0353	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0046	0.007	0.0163
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0459	0.2523
Echinococcus granulosus	tumor protein p63	0.061	0.1919	0.3691
Trichomonas vaginalis	conserved hypothetical protein	0.0221	0.0646	0.3603
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0265	0.079	0.4438
Echinococcus granulosus	lysosomal alpha glucosidase	0.0841	0.2678	0.515
Mycobacterium ulcerans	hypothetical protein	0.0159	0.0442	0.0807
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0043	0.0061	0.0147
Mycobacterium tuberculosis	Probable lipase LipE	0.0159	0.0442	0.1321
Onchocerca volvulus		0.0159	0.0442	0.2059
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0109	0.0278	0.0816
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0116	0.0299	0.139
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0251	0.0742	0.1809
Echinococcus granulosus	geminin	0.0183	0.0518	0.0997
Trichomonas vaginalis	alpha-glucosidase, putative	0.0116	0.0299	0.1595
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0742	0.4164
Echinococcus multilocularis	inositol monophosphatase 1	0.0032	0.0024	0.0021
Loa Loa (eye worm)	hypothetical protein	0.005	0.0084	0.0197
Mycobacterium tuberculosis	Probable reductase	0.0098	0.0242	0.0705
Brugia malayi	beta-lactamase family protein	0.0159	0.0442	0.1073
Trichomonas vaginalis	alpha-glucosidase, putative	0.0116	0.0299	0.1595
Treponema pallidum	hypothetical protein	0.0046	0.007	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0841	0.2678	0.2675
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0841	0.2678	0.6544
Loa Loa (eye worm)	manba-prov protein	0.0077	0.0171	0.0411
Trichomonas vaginalis	D-aminoacylase, putative	0.0159	0.0442	0.2422
Echinococcus multilocularis	neuropeptide receptor A26	0.092	0.2937	0.2935
Mycobacterium ulcerans	alpha-L-fucosidase	0.161	0.52	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0123	0.0322	0.2506
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0353	0.0857
Echinococcus multilocularis	snurportin 1	0.028	0.0836	0.0833
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0084	0.1838
Loa Loa (eye worm)	inositol-1	0.0032	0.0024	0.0051
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0459	0.2523
Brugia malayi	Inositol-1	0.0032	0.0024	0.0051
Schistosoma mansoni	inositol monophosphatase	0.0032	0.0024	0.0051
Onchocerca volvulus		0.0132	0.0353	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0005	0.0005
Schistosoma mansoni	cellular tumor antigen P53	0.0089	0.0212	0.0511
Schistosoma mansoni	hypothetical protein	0.0129	0.0343	0.0832
Echinococcus granulosus	inositol monophosphatase 1	0.0032	0.0024	0.0046
Brugia malayi	MH2 domain containing protein	0.0106	0.0267	0.0646
Loa Loa (eye worm)	thioredoxin reductase	0.0043	0.0061	0.0141
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0095	0.0232	0.0559
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0159	0.0442	0.1073
Loa Loa (eye worm)	hypothetical protein	0.0159	0.0442	0.1073
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0742	0.4164
Loa Loa (eye worm)	trehalase	0.0046	0.007	0.0163
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0742	0.4164
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.161	0.52	0.5198
Schistosoma mansoni	aldehyde dehydrogenase	0.0395	0.1214	0.2964
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0034	0.0032	0.0071
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0159	0.0442	0.0807
Mycobacterium ulcerans	hypothetical protein	0.0137	0.0368	0.0664
Brugia malayi	Importin beta-1 subunit	0.0026	0.0005	0.0005
Brugia malayi	RNA, U transporter 1	0.0074	0.0163	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0275	0.0665
Trypanosoma cruzi	hypothetical protein, conserved	0.0265	0.079	1
Mycobacterium leprae	conserved hypothetical protein	0.0159	0.0442	1
Trichomonas vaginalis	ap endonuclease, putative	0.0034	0.0032	0.0046
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0105	0.0264	0.1389
Trypanosoma brucei	trypanothione reductase	0.0043	0.0061	0.0708
Mycobacterium ulcerans	lipase LipD	0.0159	0.0442	0.0807
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0084	0.0779
Loa Loa (eye worm)	transcription factor SMAD2	0.0106	0.0267	0.0646
Onchocerca volvulus	Huntingtin homolog	0.0108	0.0275	0.1276
Mycobacterium ulcerans	beta-lactamase	0.0159	0.0442	0.0807
Loa Loa (eye worm)	latrophilin receptor protein 2	0.003	0.0018	0.0037
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0395	0.1214	0.23
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0742	0.4164
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0034	0.0032	0.0103
Schistosoma mansoni	alpha glucosidase	0.0265	0.079	0.1924
Brugia malayi	Trehalase family protein	0.0132	0.0353	0.0857
Trichomonas vaginalis	D-aminoacylase, putative	0.0159	0.0442	0.2422
Toxoplasma gondii	HEAT repeat-containing protein	0.0026	0.0005	0.0017
Brugia malayi	Beta-glucuronidase precursor	0.0106	0.0268	0.0648
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0105	0.0264	0.0638
Trichomonas vaginalis	alpha-glucosidase, putative	0.0265	0.079	0.4438
Mycobacterium tuberculosis	Probable hydrolase	0.0159	0.0442	0.1321
Onchocerca volvulus	Trehalase homolog	0.0132	0.0353	0.1643
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0265	0.079	0.1924
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0034	0.0032	0.0058
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0034	0.0032	0.0103
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0084	0.4016
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0037	0.0039	0.0195
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0109	0.0278	0.0816
Leishmania major	hypothetical protein, conserved	0.0159	0.0442	0.351
Schistosoma mansoni	hypothetical protein	0.003	0.0018	0.0037
Leishmania major	alpha glucosidase II subunit, putative	0.0265	0.079	0.6432
Brugia malayi	hypothetical protein	0.0108	0.0275	0.0665
Plasmodium vivax	glutathione reductase, putative	0.0043	0.0061	0.1313
Schistosoma mansoni	beta-galactosidase	0.0281	0.0841	0.205
Plasmodium falciparum	thioredoxin reductase	0.0043	0.0061	0.2838
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0353	0.0857
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.0459	0.2523
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0116	0.0299	0.3593
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0034	0.0032	0.0029
Onchocerca volvulus		0.0159	0.0442	0.2059
Plasmodium vivax	hypothetical protein, conserved	0.0159	0.0442	1
Leishmania major	trypanothione reductase	0.0043	0.0061	0.0308
Echinococcus multilocularis	tumor protein p63	0.061	0.1919	0.1917
Brugia malayi	Latrophilin receptor protein 2	0.003	0.0018	0.0037
Schistosoma mansoni	thyroid hormone receptor	0.014	0.0377	0.0915
Toxoplasma gondii	exonuclease III APE	0.0034	0.0032	0.0238
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0105	0.0264	0.3296
Trichomonas vaginalis	alpha-glucosidase, putative	0.0265	0.079	0.4438
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0032	0.0024	0.0241
Schistosoma mansoni	hypothetical protein	0.0065	0.0133	0.0318
Trichomonas vaginalis	alpha-glucosidase, putative	0.0116	0.0299	0.1595
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0159	0.0442	0.1321
Onchocerca volvulus		0.0132	0.0353	0.1643
Brugia malayi	latrophilin 2 splice variant baaae	0.0065	0.0133	0.0318
Toxoplasma gondii	hypothetical protein	0.0042	0.0057	0.0442
Brugia malayi	exodeoxyribonuclease III family protein	0.0034	0.0032	0.0071
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0265	0.079	0.4438
Trichomonas vaginalis	glycoside hydrolase, putative	0.0221	0.0646	0.3603
Brugia malayi	hypothetical protein	0.0046	0.007	0.0163
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.1018	0.3258	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0159	0.0442	0.1321
Mycobacterium tuberculosis	Probable lipase LipD	0.0159	0.0442	0.1321
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0251	0.0742	0.1809
Loa Loa (eye worm)	trehalase	0.0132	0.0353	0.0857
Loa Loa (eye worm)	beta-lactamase	0.0159	0.0442	0.1073
Onchocerca volvulus		0.0132	0.0353	0.1643
Trichomonas vaginalis	glycoside hydrolases, putative	0.0267	0.0796	0.4475
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0034	0.0032	0.0066
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0034	0.0032	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0095	0.0232	0.0559
Schistosoma mansoni	hypothetical protein	0.0183	0.0518	0.126
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0235	0.0688	0.3851
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0105	0.0264	0.313
Loa Loa (eye worm)	TRE-1 protein	0.0132	0.0353	0.0857
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0129	0.0343	0.066
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0098	0.0242	0.0705
Echinococcus multilocularis	geminin	0.0183	0.0518	0.0515
Brugia malayi	trehalase	0.0046	0.007	0.0163
Echinococcus granulosus	fucosidase alpha L 1 tissue	0.161	0.52	1
Schistosoma mansoni	hypothetical protein	0.003	0.0018	0.0037
Echinococcus granulosus	neuropeptide receptor A26	0.092	0.2937	0.5649
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0395	0.1214	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: Confirmation of Inhibitors of Human alpha-Galactosidase Using Spleen Homogenate. (Class of assay: confirmatory) [Related pubchem assays: 1472, 1467 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1495407

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1367691