Detailed information for compound 1369692

Basic information

Technical information
  • TDR Targets ID: 1369692
  • Name: 5-chloro-N-[(7-methylimidazo[1,2-a]pyridin-2- yl)methyl]thiophene-2-sulfonamide
  • MW: 341.836 | Formula: C13H12ClN3O2S2
  • H donors: 1 H acceptors: 3 LogP: 3.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(s1)S(=O)(=O)NCc1nc2n(c1)ccc(c2)C
  • InChi: 1S/C13H12ClN3O2S2/c1-9-4-5-17-8-10(16-12(17)6-9)7-15-21(18,19)13-3-2-11(14)20-13/h2-6,8,15H,7H2,1H3
  • InChiKey: ZWIWXNQNQZCESK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-chloro-N-[(7-methyl-2-imidazo[1,2-a]pyridinyl)methyl]-2-thiophenesulfonamide
  • MLS000103870
  • SMR000018237
  • ZINC04248418
  • IDI1_029262
  • ChemDiv3_011704

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0036 0.0782 0.0673
Echinococcus granulosus mitogen activated protein kinase 15 0.0036 0.0782 0.0673
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Brugia malayi GSG2 0.0203 0.5357 0.7126
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0782 0.0816
Loa Loa (eye worm) haspin protein kinase 0.0203 0.5357 0.5302
Echinococcus granulosus serine:threonine protein kinase haspin 0.0203 0.5357 0.5302
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.13 0.1197
Schistosoma mansoni ran 0.0026 0.0486 0.0373
Brugia malayi follicle stimulating hormone receptor 0.028 0.747 1
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0782 0.0816
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0486 0.0373
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0036 0.0782 0.0673
Brugia malayi Cell division protein kinase 2 0.0036 0.0782 0.0905
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.13 0.1197
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Echinococcus multilocularis dual specificity 0.0158 0.4123 0.4053
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0977 1
Schistosoma mansoni hypothetical protein 0.0372 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0158 0.4123 0.4053
Mycobacterium leprae Probable lipase LipE 0.0043 0.0977 0.5
Echinococcus granulosus dual specificity 0.0158 0.4123 0.4053
Onchocerca volvulus Huntingtin homolog 0.0148 0.3848 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.747 0.744
Brugia malayi RNA, U transporter 1 0.0099 0.2503 0.3246
Entamoeba histolytica protein kinase domain containing protein 0.0158 0.4123 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0977 0.5
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0739 0.0629
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0782 0.0816
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.13 0.1197
Schistosoma mansoni protein kinase 0.0036 0.0782 0.0673
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0558 0.0197
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.4123 1
Brugia malayi hypothetical protein 0.0203 0.5357 0.7126
Echinococcus multilocularis dual specificity 0.0158 0.4123 0.4053
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0977 0.1169
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0036 0.0782 0.6045
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0158 0.4123 0.4053
Onchocerca volvulus 0.0043 0.0977 0.2304
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1797 0.17
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0036 0.0782 0.1898
Schistosoma mansoni hypothetical protein 0.0035 0.0745 0.0635
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0782 0.0673
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0782 0.0816
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1797 0.17
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0036 0.0782 0.0816
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0739 0.0695
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0158 0.4123 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0977 0.1349
Entamoeba histolytica hypothetical protein 0.0035 0.0745 0.0712
Schistosoma mansoni importin beta-1 0.0035 0.0739 0.0629
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Loa Loa (eye worm) beta-lactamase 0.0043 0.0977 0.087
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.13 0.1609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.13 0.1197
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0486 0.0502
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.13 0.1197
Echinococcus granulosus cyclin dependent kinase 9 0.0036 0.0782 0.0673
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.7417 1
Brugia malayi cyclin-dependent kinase 7 homolog 0.0036 0.0782 0.0905
Giardia lamblia Kinase, CAMK CAMKL 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.13 0.1197
Plasmodium falciparum MO15-related protein kinase 0.0036 0.0782 1
Echinococcus multilocularis snurportin 1 0.0372 1 1
Echinococcus granulosus dual specificity 0.0158 0.4123 0.4053
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0977 0.087
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Onchocerca volvulus Huntingtin homolog 0.0148 0.3848 1
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0158 0.4123 0.5448
Echinococcus multilocularis dual specificity 0.0158 0.4123 0.4053
Leishmania major hypothetical protein, conserved 0.0043 0.0977 0.1349
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.4123 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1797 0.1274
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0977 0.1349
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1797 0.3605
Echinococcus granulosus dual specificity 0.0158 0.4123 0.4053
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0036 0.0782 0.0816
Brugia malayi hypothetical protein 0.0148 0.3848 0.5075
Brugia malayi beta-lactamase family protein 0.0043 0.0977 0.1169
Onchocerca volvulus 0.0043 0.0977 0.2304
Brugia malayi Importin beta-1 subunit 0.0035 0.0739 0.0845
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0035 0.0745 0.0635
Echinococcus multilocularis cyclin dependent kinase 9 0.0036 0.0782 0.0673
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.4123 1
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0036 0.0782 0.0673
Loa Loa (eye worm) hypothetical protein 0.0043 0.0977 0.087
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis serine/threonine kinase, putative 0.0036 0.0782 0.0816
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0158 0.4123 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0977 0.1349
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0977 0.1349
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0036 0.0782 0.6045
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0558 0.0197
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0782 0.0816
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1797 0.17
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0203 0.5357 0.5302
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0036 0.0782 0.0673
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0739 0.1791
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0558 0.0197
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0158 0.4123 1
Schistosoma mansoni serine/threonine kinase 0.0036 0.0782 0.0673
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1797 1
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0977 0.087
Loa Loa (eye worm) hypothetical protein 0.0043 0.0977 0.087
Entamoeba histolytica protein kinase domain containing protein 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0977 0.1349
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Giardia lamblia Kinase, CAMK CAMKL 0.0036 0.0782 0.0816
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0977 0.087
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0158 0.4123 1
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis esterase, putative 0.0043 0.0977 0.1349
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Loa Loa (eye worm) hypothetical protein 0.0043 0.0977 0.087
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0036 0.0782 0.0816
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0977 0.2369
Plasmodium vivax importin-beta 2, putative 0.0035 0.0739 0.515
Loa Loa (eye worm) hypothetical protein 0.0148 0.3848 0.3776
Giardia lamblia Kinase, CAMK CAMKL 0.0036 0.0782 0.0816
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0036 0.0782 0.0816
Giardia lamblia Kinase, CMGC DYRK 0.0158 0.4123 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0977 0.087
Entamoeba histolytica cell division protein kinase 2, putative 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Onchocerca volvulus 0.0043 0.0977 0.2304
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1797 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1797 0.3605
Plasmodium falciparum importin beta, putative 0.0035 0.0739 0.852
Entamoeba histolytica hypothetical protein 0.0028 0.0558 0.0197
Loa Loa (eye worm) haspin protein kinase 0.0203 0.5357 0.5302
Leishmania major importin beta-1 subunit, putative 0.0028 0.0558 0.0197
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0486 0.1178
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Loa Loa (eye worm) haspin protein kinase 0.0204 0.5394 0.534
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1797 1
Trichomonas vaginalis protein kinase atmrk1, putative 0.0036 0.0782 0.0816
Echinococcus granulosus serine:threonine protein kinase NLK 0.0036 0.0782 0.0673
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0739 0.1791
Echinococcus granulosus serine:threonine protein kinase haspin 0.0203 0.5357 0.5302
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Loa Loa (eye worm) hypothetical protein 0.0148 0.3848 0.3776
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0977 0.087
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Toxoplasma gondii ABC1 family protein 0.0043 0.0977 0.1349
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0036 0.0782 0.0816
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.4123 1
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1797 0.17
Loa Loa (eye worm) hypothetical protein 0.0043 0.0977 0.087
Schistosoma mansoni ran 0.0026 0.0486 0.0373
Trypanosoma brucei protein kinase, putative 0.0036 0.0782 0.1898
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0977 0.1349
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.4123 1
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Echinococcus granulosus importin subunit beta 1 0.0035 0.0739 0.0629
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0036 0.0782 0.0673
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0203 0.5357 0.5302
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Brugia malayi Protein kinase domain containing protein 0.0036 0.0782 0.0905
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0977 0.1349
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0558 0.0197
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0782 0.0816
Leishmania major serine/threonine kinase-like protein, putative 0.0036 0.0782 0.0816
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.13 0.1197
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0486 0.0373
Echinococcus multilocularis hypothetical protein 0.0035 0.0745 0.0635
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CMGC family protein kinase 0.0036 0.0782 0.0816
Loa Loa (eye worm) hypothetical protein 0.0035 0.0739 0.0629
Loa Loa (eye worm) hypothetical protein 0.0043 0.0977 0.087
Brugia malayi beta-lactamase family protein 0.0043 0.0977 0.1169
Schistosoma mansoni hypothetical protein 0.0203 0.5357 0.5302
Loa Loa (eye worm) hypothetical protein 0.0043 0.0977 0.087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.13 0.1197
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CMGC family protein kinase 0.0158 0.4123 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0486 0.0373
Brugia malayi beta-lactamase 0.0043 0.0977 0.1169
Echinococcus granulosus serine:threonine protein kinase haspin 0.0203 0.5357 0.5302
Entamoeba histolytica protein kinase, putative 0.0158 0.4123 1
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816
Trichomonas vaginalis CAMK family protein kinase 0.0036 0.0782 0.0816

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 100 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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