Detailed information for compound 1373117

Basic information

Technical information
  • TDR Targets ID: 1373117
  • Name: 2-morpholin-4-yl-4-thiophen-2-yl-6-(trifluoro methyl)pyrimidine
  • MW: 315.314 | Formula: C13H12F3N3OS
  • H donors: 0 H acceptors: 2 LogP: 2.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: FC(c1nc(nc(c1)c1cccs1)N1CCOCC1)(F)F
  • InChi: 1S/C13H12F3N3OS/c14-13(15,16)11-8-9(10-2-1-7-21-10)17-12(18-11)19-3-5-20-6-4-19/h1-2,7-8H,3-6H2
  • InChiKey: XKXUWIIAACKXEG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-morpholino-4-(2-thienyl)-6-(trifluoromethyl)pyrimidine
  • EU-0021847
  • 4-[4-(2-thienyl)-6-(trifluoromethyl)-2-pyrimidinyl]morpholine
  • MLS000100385
  • SMR000082715
  • ZINC00213269

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cpg binding protein 0.0032 0.0296 0.0336
Schistosoma mansoni hypothetical protein 0.0181 0.2026 0.2446
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0199 0.2238 0.2221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0422 0.4835 0.7856
Brugia malayi Inositol-1 0.0045 0.0438 0.0662
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0298 0.0277
Echinococcus granulosus muscleblind protein 0.016 0.1776 0.2142
Schistosoma mansoni steroid hormone receptor ad4bp 0.0422 0.4835 0.5875
Entamoeba histolytica glutamine synthetase, putative 0.018 0.2013 1
Brugia malayi Pre-SET motif family protein 0.0223 0.2514 0.4059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0562 0.0865
Wolbachia endosymbiont of Brugia malayi glutamine synthetase 0.018 0.2013 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0199 0.2238 0.2221
Schistosoma mansoni Smad4 0.001 0.0033 0.0015
Loa Loa (eye worm) nuclear receptor NHR-67 0.0199 0.2238 0.3607
Schistosoma mansoni cpg binding protein 0.0032 0.0296 0.0336
Toxoplasma gondii NAC domain-containing protein 0.0037 0.0354 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0422 0.4835 0.7856
Plasmodium vivax glutamine synthetase, putative 0.0458 0.5255 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0199 0.2238 0.2705
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Echinococcus multilocularis muscleblind protein 1 0.016 0.1776 0.1758
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0116 0.0115
Schistosoma mansoni hypothetical protein 0.0437 0.5004 0.6081
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0562 0.066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0422 0.4835 0.4824
Schistosoma mansoni nuclear hormone receptor 0.0199 0.2238 0.2705
Brugia malayi beta-NAC-like protein 0.0037 0.0354 0.0524
Loa Loa (eye worm) hypothetical protein 0.0223 0.2516 0.4062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0422 0.4835 0.7856
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.069 0.0816
Brugia malayi nuclear receptor RXR 0.0199 0.2238 0.3607
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0115 0.0134
Schistosoma mansoni nuclear receptor 0.0199 0.2238 0.2705
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0199 0.2238 0.2705
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0033 0.0015
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0422 0.4835 0.5875
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0033 0.0012
Mycobacterium ulcerans glutamine synthetase GlnA1 0.0458 0.5255 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0422 0.4835 0.7768
Brugia malayi Pre-SET motif family protein 0.0033 0.0298 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0354 0.1232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0422 0.4835 0.7856
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0422 0.4835 0.5875
Loa Loa (eye worm) hypothetical protein 0.0053 0.0539 0.0827
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0438 0.0399
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0115 0.0094
Loa Loa (eye worm) hypothetical protein 0.0422 0.4835 0.7856
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0422 0.4835 0.5875
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0298 0.0338
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0115 0.0114
Brugia malayi ecdysteroid receptor 0.0422 0.4835 0.7856
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0422 0.4835 0.7856
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Onchocerca volvulus 0.0199 0.2238 0.3343
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0422 0.4835 0.7856
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0069 0.0726 0.0859
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0094
Brugia malayi nuclear receptor NHR-88 0.0422 0.4835 0.7856
Schistosoma mansoni hypothetical protein 0.0017 0.0115 0.0114
Echinococcus multilocularis cpg binding protein 0.0032 0.0296 0.0276
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0354 0.0294
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0199 0.2238 0.2221
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Brugia malayi photoreceptor-specific nuclear receptor 0.0422 0.4835 0.7856
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0116 0.0134
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.0354 0.0294
Loa Loa (eye worm) ICD-1 protein 0.0037 0.0354 0.0524
Schistosoma mansoni hypothetical protein 0.0017 0.0115 0.0114
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0438 0.1526
Loa Loa (eye worm) hypothetical protein 0.0422 0.4835 0.7856
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0199 0.2238 0.3343
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0422 0.4835 0.7856
Echinococcus granulosus FTZ F1 alpha 0.0422 0.4835 0.5875
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0199 0.2238 0.3607
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0422 0.4835 0.5875
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0726 0.0859
Brugia malayi nuclear hormone receptor 0.0199 0.2238 0.3607
Brugia malayi glutamine synthetase 0.0254 0.2879 0.4656
Loa Loa (eye worm) hypothetical protein 0.016 0.1776 0.2851
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0422 0.4835 0.5875
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0298 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0298 0.0338
Trichomonas vaginalis set domain proteins, putative 0.0254 0.2872 1
Schistosoma mansoni RAR-like nuclear receptor 0.0422 0.4835 0.5875
Schistosoma mansoni hypothetical protein 0.0036 0.0343 0.0392
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0069 0.0726 0.1132
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0562 0.066
Onchocerca volvulus 0.0199 0.2238 0.3343
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0199 0.2238 0.3607
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0043 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0115 0.0134
Loa Loa (eye worm) hypothetical protein 0.0223 0.2516 0.4062
Mycobacterium tuberculosis Probable glutamine synthetase GlnA3 (glutamine synthase) (GS-I) 0.018 0.2013 0.3692
Loa Loa (eye worm) hypothetical protein 0.016 0.1776 0.2851
Brugia malayi nuclear receptor NHR-88 0.0199 0.2238 0.3607
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0094
Trichomonas vaginalis glutamine synthetase-bacteria, putative 0.018 0.2013 0.7009
Brugia malayi conserved hypotetical protein 0.0199 0.2238 0.3607
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0422 0.4835 0.5875
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0422 0.4835 0.5875
Loa Loa (eye worm) hypothetical protein 0.0422 0.4835 0.7856
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0539 0.0827
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0438 0.1526
Echinococcus multilocularis FTZ F1 alpha 0.0422 0.4835 0.4824
Loa Loa (eye worm) hypothetical protein 0.0223 0.2516 0.4062
Schistosoma mansoni glutamine synthetase 1 2 (glutamate-amonia ligase) (gs) 0.0713 0.8215 1
Schistosoma mansoni zinc finger protein 0.0199 0.2238 0.2705
Trypanosoma cruzi glutamine synthetase, putative 0.0713 0.8215 1
Onchocerca volvulus 0.0033 0.0298 0.0037
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0539 0.0827
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0422 0.4835 0.7856
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0199 0.2238 0.2221
Onchocerca volvulus 0.0254 0.2872 0.4422
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0199 0.2238 0.2221
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.0354 0.0294
Schistosoma mansoni retinoic acid receptor RXR 0.0422 0.4835 0.5875
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0562 0.066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0115 0.0114
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0094
Trichomonas vaginalis glutamine synthetase, putative 0.018 0.2013 0.7009
Echinococcus multilocularis transcription factor btf3 0.0037 0.0354 0.0333
Echinococcus granulosus ecdysone induced protein 78C 0.0422 0.4835 0.5875
Echinococcus multilocularis Smad4 0.001 0.0033 0.0012
Echinococcus multilocularis glutamine synthetase 0.0713 0.8215 0.8211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0422 0.4835 0.7856
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0298 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0422 0.4835 0.7856
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0042 0.0014
Plasmodium vivax SET domain protein, putative 0.0033 0.0298 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0422 0.4835 0.7856
Echinococcus granulosus Nuclear hormone receptor HR96 0.0199 0.2238 0.2705
Echinococcus granulosus thyroid hormone receptor alpha 0.0199 0.2238 0.2705
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0199 0.2238 0.2221
Loa Loa (eye worm) DR-78 0.0199 0.2238 0.3607
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0033 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0223 0.2516 0.4062
Loa Loa (eye worm) hypothetical protein 0.0535 0.6145 1
Schistosoma mansoni cpg binding protein 0.0031 0.0276 0.0311
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0276 0.0397
Schistosoma mansoni glutamine synthetase bacteria 0.018 0.2013 0.243
Schistosoma mansoni transcription factor btf3 0.0037 0.0354 0.0406
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0043 0.0027
Schistosoma mansoni hypothetical protein 0.0017 0.0115 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0354 0.1232
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0199 0.2238 0.2705
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0562 0.066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0223 0.2516 0.3045
Loa Loa (eye worm) nuclear hormone receptor 0.0199 0.2238 0.3607
Schistosoma mansoni nuclear hormone receptor 0.0422 0.4835 0.5875
Loa Loa (eye worm) steroid hormone receptor 0.0422 0.4835 0.7856
Plasmodium falciparum glutamine synthetase, putative 0.0458 0.5255 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.0276 0.0397
Schistosoma mansoni hypothetical protein 0.0181 0.2026 0.2446
Echinococcus granulosus Nuclear hormone receptor HR96 0.0199 0.2238 0.2705
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0438 0.0509
Loa Loa (eye worm) hypothetical protein 0.0422 0.4835 0.7856
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Echinococcus granulosus GPCR family 2 0.0017 0.0115 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0422 0.4835 0.7856
Brugia malayi hypothetical protein 0.0535 0.6145 1
Echinococcus granulosus neuropeptide s receptor 0.0494 0.5668 0.6891
Loa Loa (eye worm) hypothetical protein 0.0422 0.4835 0.7856
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0277 0.0311
Leishmania major glutamine synthetase, putative 0.0713 0.8215 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0562 0.0542
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0438 0.0399
Schistosoma mansoni coup transcription factor 0.0422 0.4835 0.5875
Echinococcus granulosus geminin 0.0181 0.2026 0.2446
Brugia malayi Muscleblind-like protein 0.016 0.1776 0.2851
Loa Loa (eye worm) hypothetical protein 0.0422 0.4835 0.7856
Brugia malayi orphan nuclear receptor NR2E1 0.0199 0.2238 0.3607
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0438 0.0399
Echinococcus multilocularis geminin 0.0181 0.2026 0.2009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0422 0.4835 0.5875
Schistosoma mansoni inositol monophosphatase 0.0045 0.0438 0.0509
Schistosoma mansoni smad1 5 8 and 0.001 0.0033 0.0015
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0116 0.0115
Mycobacterium leprae PROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II) 0.0458 0.5255 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0422 0.4835 0.7856
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0726 0.0596
Loa Loa (eye worm) inositol-1 0.0045 0.0438 0.0662
Echinococcus granulosus smad 0.001 0.0033 0.0015
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0438 0.0628
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0438 0.1526
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0422 0.4835 0.4824
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0671 0.1043
Brugia malayi nuclear hormone receptor family member nhr-6 0.0199 0.2238 0.3607
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0033 0.0012
Mycobacterium ulcerans glutamine synthetase 0.0458 0.5255 1
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0343 0.0506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0562 0.066
Brugia malayi Nuclear hormone receptor E75 0.0199 0.2238 0.3607
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0384 0.0522
Brugia malayi Steroid receptor seven-up type 2 0.0422 0.4835 0.7856
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0422 0.4835 0.7768
Mycobacterium tuberculosis Probable glutamine synthetase GlnA2 (glutamine synthase) (GS-II) 0.0458 0.5255 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0298 0.0433
Schistosoma mansoni hypothetical protein 0.0017 0.0115 0.0114
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0422 0.4835 0.5875
Toxoplasma gondii glutamine synthetase, type I, putative 0.0458 0.5255 1
Schistosoma mansoni lozenge 0.0067 0.07 0.0828
Echinococcus multilocularis Protein lozenge 0.0067 0.07 0.068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0115 0.0134
Loa Loa (eye worm) hypothetical protein 0.0223 0.2516 0.4062
Brugia malayi ecdysone receptor 0.0199 0.2238 0.3607
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0422 0.4835 0.7856
Brugia malayi isocitrate dehydrogenase 0.0017 0.0116 0.0134
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0223 0.2514 0.4059
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0223 0.2516 0.3045
Brugia malayi tailless protein 0.0199 0.2238 0.3607
Schistosoma mansoni nuclear hormone receptor 0.0199 0.2238 0.2705
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0562 0.0542
Schistosoma mansoni glutamine synthetase bacteria 0.018 0.2013 0.243
Brugia malayi nuclear receptor RXR 0.0223 0.2516 0.4062
Echinococcus granulosus neuropeptide receptor A26 0.0494 0.5668 0.6891
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0069 0.0726 0.1187
Echinococcus granulosus Smad4 0.001 0.0033 0.0015
Brugia malayi steroid hormone receptor 0.0422 0.4835 0.7856
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0609 0.0961
Entamoeba histolytica glutamine synthetase, putative 0.018 0.2013 1
Echinococcus multilocularis GPCR, family 2 0.0017 0.0115 0.0094
Brugia malayi hypothetical protein 0.0223 0.2516 0.4062
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0539 0.0827
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0115 0.0094
Schistosoma mansoni thyroid hormone receptor 0.0422 0.4835 0.5875
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.0354 0.0464
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0043 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0422 0.4835 0.5875
Echinococcus multilocularis neuropeptide receptor A26 0.0494 0.5668 0.5659
Echinococcus multilocularis smad 0.001 0.0033 0.0012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0422 0.4835 0.4824
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0422 0.4835 0.4824
Onchocerca volvulus Glutamine synthetase homolog 0.0458 0.5255 0.8483
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0438 0.0399
Brugia malayi Nuclear hormone receptor-like 1 0.0422 0.4835 0.7856
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0199 0.2238 0.2705
Onchocerca volvulus Bile acid receptor homolog 0.0422 0.4835 0.7768
Brugia malayi Nuclear hormone receptor E75 0.0199 0.2238 0.3607
Loa Loa (eye worm) runx1 0.0067 0.07 0.1091
Echinococcus granulosus glutamine synthetase 0.0713 0.8215 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0562 0.0865
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0354 0.1232
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0116 0.0094
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0116 0.0134
Schistosoma mansoni nuclear receptor nhr-48 0.0199 0.2238 0.2705
Loa Loa (eye worm) hypothetical protein 0.0199 0.2238 0.3607
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0223 0.2516 0.4062
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0298 0.0338
Schistosoma mansoni smad1 5 8 and 0.001 0.0033 0.0015
Onchocerca volvulus 0.0422 0.4835 0.7768
Loa Loa (eye worm) hypothetical protein 0.0422 0.4835 0.7856
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0422 0.4835 0.7856
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0422 0.4835 0.7856
Trypanosoma cruzi glutamine synthetase, putative 0.0713 0.8215 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0199 0.2238 0.3607
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0033 0.0015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0422 0.4835 0.4824
Loa Loa (eye worm) hypothetical protein 0.0535 0.6145 1
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.0354 0.0464
Echinococcus granulosus transcription factor btf3 0.0037 0.0354 0.0406
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0223 0.2516 0.3045
Brugia malayi hypothetical protein 0.0199 0.2238 0.3607
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0223 0.2516 0.25
Echinococcus multilocularis neuropeptide s receptor 0.0494 0.5668 0.5659
Schistosoma mansoni smad1 5 8 and 0.001 0.0033 0.0015
Echinococcus multilocularis muscleblind protein 0.016 0.1776 0.1758
Echinococcus granulosus nuclear receptor nhr 48 0.0199 0.2238 0.2705
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0422 0.4835 0.7856
Brugia malayi nuclear receptor NHR-67 0.0199 0.2238 0.3607
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1597 0.2559
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0298 0.0338
Schistosoma mansoni inositol monophosphatase 0.0045 0.0438 0.0509
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0069 0.0726 0.0706
Trypanosoma brucei glutamine synthetase, putative 0.0713 0.8215 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0422 0.4835 0.4824
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0069 0.0726 0.0753
Brugia malayi hypothetical protein 0.0199 0.2238 0.3607
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0422 0.4835 0.5875
Loa Loa (eye worm) hypothetical protein 0.0422 0.4835 0.7856
Brugia malayi hypothetical protein 0.0223 0.2516 0.4062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0422 0.4835 0.5875
Brugia malayi MH2 domain containing protein 0.0144 0.1597 0.2559
Brugia malayi Nuclear hormone receptor-like 1 0.0223 0.2516 0.4062
Echinococcus multilocularis dnaJ subfamily B 0.0437 0.5004 0.4993
Loa Loa (eye worm) hypothetical protein 0.0036 0.0343 0.0506
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0298 0.0338
Leishmania major basic transcription factor 3a, putative 0.0037 0.0354 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0422 0.4835 0.7856
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1597 0.2559
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0115 0.0134
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0422 0.4835 0.5875
Schistosoma mansoni thyroid hormone receptor 0.0422 0.4835 0.5875
Schistosoma mansoni cpg binding protein 0.0032 0.0296 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0422 0.4835 0.7856
Echinococcus granulosus dnaJ subfamily B 0.0437 0.5004 0.6081
Brugia malayi nuclear hormone receptor 0.0422 0.4835 0.7856
Mycobacterium ulcerans hypothetical protein 0.018 0.2013 0.3269
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0438 0.051
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0116 0.0094
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0199 0.2238 0.3343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0422 0.4835 0.7856
Echinococcus multilocularis thyroid hormone receptor alpha 0.0422 0.4835 0.4824
Schistosoma mansoni nuclear receptor 0.0199 0.2238 0.2705
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0069 0.0726 0.0596
Loa Loa (eye worm) hypothetical protein 0.0223 0.2516 0.4062
Loa Loa (eye worm) Gln-2 protein 0.0458 0.5255 0.8543
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0422 0.4835 0.4824
Onchocerca volvulus 0.0535 0.6145 1
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0438 0.0418
Schistosoma mansoni smad 0.001 0.0033 0.0015

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2818 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1484, AID504370, AID504374, AID504375] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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