Detailed information for compound 1376857

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.442 | Formula: C24H22N2O5
  • H donors: 2 H acceptors: 3 LogP: 4.15 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)CC(=O)Nc1ccc(c(c1)O)c1nc2c(o1)ccc(c2)C
  • InChi: 1S/C24H22N2O5/c1-14-4-8-20-18(10-14)26-24(31-20)17-7-6-16(13-19(17)27)25-23(28)12-15-5-9-21(29-2)22(11-15)30-3/h4-11,13,27H,12H2,1-3H3,(H,25,28)
  • InChiKey: SBDXCGCSNNINLK-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0067 0.0238 0.0235
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0559 0.6411
Schistosoma mansoni DNA polymerase eta 0.0054 0.0174 0.0421
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0126 0.0721
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0018 0.0328
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0126 0.0721
Leishmania major cathepsin L-like protease 0.002 0.0003 0.0013
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0018 0.0204
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0003 0.004
Trypanosoma brucei rac serine-threonine kinase, putative 0.0127 0.0543 0.311
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0055 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0065 0.0229 0.0227
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0018 0.0102
Echinococcus multilocularis protein kinase c iota type 0.0073 0.0269 0.0553
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0174 0.0174
Trypanosoma cruzi Protein kinase B 0.0066 0.0234 0.1338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0018 0.0043
Toxoplasma gondii cathepsin CPL 0.002 0.0003 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0128 0.031
Toxoplasma gondii AGC kinase 0.0045 0.0128 0.2401
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.026 0.063
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.011 0.0455 0.0452
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.0773 0.4431
Plasmodium falciparum thioredoxin reductase 0.0057 0.0189 0.5731
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0189 0.0186
Loa Loa (eye worm) glutathione reductase 0.0057 0.0189 0.0186
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0003 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Trichomonas vaginalis cAMP-dependent protein kinase catalytic subunit, putative 0.0048 0.0146 0.2676
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0065 0.0229 0.0472
Mycobacterium tuberculosis Probable reductase 0.013 0.0559 0.6411
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.029 0.166
Leishmania major DNA polymerase eta, putative 0.0038 0.0093 0.0528
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0074 0.0274 0.0274
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0003 0.0005
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0126 0.0259
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.0003 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0207 0.1182
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0045 0.0128 0.0732
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.033 0.08
Loa Loa (eye worm) hypothetical protein 0.0071 0.0258 0.0255
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1744 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0632 1
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0128 0.2354
Schistosoma mansoni serine/threonine kinase 0.0065 0.0229 0.0556
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0189 0.2165
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0126 0.2313
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0003 0.004
Echinococcus granulosus microtubule associated protein 2 0.0833 0.4113 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.4113 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0126 0.0259
Echinococcus multilocularis serine:threonine protein kinase N2 0.0065 0.0229 0.0472
Plasmodium vivax vivapain-2 0.002 0.0003 0.0098
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0773 0.4431
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0269 0.0652
Brugia malayi Cathepsin L-like precursor 0.002 0.0003 0.0003
Brugia malayi Inositol-1 0.0045 0.0126 0.0126
Brugia malayi p70 ribosomal S6 kinase beta 0.0125 0.0532 0.0532
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0559 0.6411
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0074 0.0274 0.157
Loa Loa (eye worm) AGC/PKA protein kinase 0.0045 0.0128 0.0125
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0543 1
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.026 0.063
Plasmodium vivax glutathione reductase, putative 0.0057 0.0189 0.8472
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0126 0.0305
Brugia malayi Thioredoxin reductase 0.0057 0.0189 0.0189
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0085 0.033 0.0679
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0189 0.8472
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0093 0.0528
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0074 0.0274 0.3143
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0126 0.2318
Entamoeba histolytica protein kinase, putative 0.0125 0.0532 0.1296
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0045 0.0128 0.0128
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.026 0.063
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0126 0.2318
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0075 0.0278 0.0275
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0065 0.0229 0.0472
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0045 0.0128 0.0732
Leishmania major protein kinase A catalytic subunit isoform 2 0.0045 0.0128 0.0732
Schistosoma mansoni protein kinase C mu 0.0075 0.0278 0.0674
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0269 0.0652
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0543 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0126 0.2318
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0064 0.0223 0.6765
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0126 0.2313
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0229 0.4218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0064 0.0223 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.026 0.0257
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0064 0.0223 0.0541
Echinococcus granulosus NDR protein kinase 0.0065 0.0229 0.0556
Loa Loa (eye worm) hypothetical protein 0.0063 0.0218 0.0216
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0126 0.0306
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0045 0.0128 0.0732
Echinococcus multilocularis cysteine protease 0.002 0.0003 0.0005
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0045 0.0128 0.3878
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0189 0.1082
Leishmania major trypanothione reductase 0.0057 0.0189 0.1082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0018 0.0328
Toxoplasma gondii hypothetical protein 0.0059 0.0198 0.3712
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.006 0.0203 0.0493
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0126 0.0126
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0003 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0003 0.0003
Leishmania major cathepsin L-like protease 0.0077 0.029 0.166
Brugia malayi jmjC domain containing protein 0.0071 0.026 0.026
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0234 0.0566
Loa Loa (eye worm) AGC/PKN protein kinase 0.0065 0.0229 0.0227
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.1744 1
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0018 0.0204
Entamoeba histolytica protein kinase, putative 0.0127 0.0543 0.1322
Trichomonas vaginalis AGC family protein kinase 0.011 0.0455 0.8373
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.026 0.0534
Brugia malayi C1-like domain containing protein 0.0075 0.0278 0.0278
Onchocerca volvulus 0.0641 0.3141 0.9937
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Leishmania major protein kinase A catalytic subunit isoform 1 0.0045 0.0128 0.0732
Schistosoma mansoni serine/threonine-protein kinase 0.0066 0.0234 0.0567
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0559 0.6411
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0045 0.0128 0.0263
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0018 0.0043
Echinococcus multilocularis serine:threonine protein kinase N2 0.0065 0.0229 0.0472
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0041 0.0108 0.0262
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0632 0.7254
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0018 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0018 0.0102
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0126 0.0306
Plasmodium falciparum cysteine proteinase falcipain 2a 0.002 0.0003 0.0066
Plasmodium falciparum cysteine proteinase falcipain 2b 0.002 0.0003 0.0066
Echinococcus multilocularis cysteine protease 0.002 0.0003 0.0005
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0229 0.0556
Entamoeba histolytica protein kinase, putative 0.0065 0.0229 0.0555
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0003 0.004
Brugia malayi Cathepsin L-like precursor 0.002 0.0003 0.0003
Echinococcus multilocularis dna polymerase eta 0.0054 0.0174 0.0357
Mycobacterium ulcerans hypothetical protein 0.0081 0.031 0.3551
Leishmania major cathepsin L-like protease 0.002 0.0003 0.0013
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0075 0.0278 0.0278
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0003 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0055 0.0309
Leishmania major DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Trichomonas vaginalis serine/threonine-protein kinase, putative 0.0048 0.0146 0.2676
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0543 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0045 0.0128 0.0732
Brugia malayi Cathepsin L-like precursor 0.002 0.0003 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Plasmodium vivax vivapain-2 0.002 0.0003 0.0098
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0055 0.1013
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.4113 0.8479
Giardia lamblia DINP protein human, muc B family 0.0023 0.0018 0.0799
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0018 0.0204
Echinococcus granulosus protein kinase c iota type 0.0073 0.0269 0.0652
Echinococcus multilocularis serine:threonine protein kinase 38 0.0065 0.0229 0.0472
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0003 0.004
Brugia malayi Cathepsin L-like precursor 0.002 0.0003 0.0003
Leishmania major hypothetical protein, conserved 0.003 0.0055 0.0309
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0102 0.1169
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0543 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0229 0.0227
Leishmania major DNA polymerase eta, putative 0.0054 0.0174 0.0994
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0003 0.0005
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.026 0.0534
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Echinococcus granulosus Protein kinase C brain isozyme 0.0073 0.0269 0.0652
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0126 0.0306
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0003 0.004
Leishmania major protein kinase A catalytic subunit 0.0045 0.0128 0.0732
Trypanosoma brucei trypanothione reductase 0.0057 0.0189 0.1082
Entamoeba histolytica PH domain containing protein kinase, putative 0.0047 0.0139 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Toxoplasma gondii AGC kinase 0.0045 0.0128 0.2401
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0128 0.031
Toxoplasma gondii AGC kinase 0.0125 0.0532 1
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0045 0.0128 0.0732
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0126 0.144
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0126 0.0719
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0189 0.0459
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0045 0.0128 0.0263
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Treponema pallidum NADH oxidase 0.002 0.0001 0.5
Echinococcus granulosus dna polymerase eta 0.0054 0.0174 0.0421
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0018 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0126 0.0306
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0045 0.0128 0.0732
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0045 0.0126 0.0124
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0126 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0559 0.8614
Echinococcus multilocularis Glutaredoxin protein 5 0.006 0.0203 0.0418
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0256 0.1466
Giardia lamblia Kinase, AGC PKA 0.0045 0.0128 0.5733
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Onchocerca volvulus 0.0071 0.0258 0.0808
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0003 0.004
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0018 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Echinococcus granulosus dna polymerase kappa 0.0023 0.0018 0.0043
Loa Loa (eye worm) hypothetical protein 0.0073 0.0269 0.0266
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Leishmania major cathepsin L-like protease 0.0077 0.029 0.166
Onchocerca volvulus 0.0073 0.0269 0.0842
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0125 0.0532 0.0529
Loa Loa (eye worm) hypothetical protein 0.0045 0.0128 0.0125
Echinococcus multilocularis expressed conserved protein 0.0085 0.033 0.0679
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Brugia malayi protein kinase C II. 0.0073 0.0269 0.0269
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.0274 0.3143
Loa Loa (eye worm) hypothetical protein 0.0054 0.0174 0.0171
Brugia malayi Protein kinase domain containing protein 0.0127 0.0543 0.0543
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0106 0.0435 0.8008
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0543 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0126 0.0719
Toxoplasma gondii thioredoxin reductase 0.0057 0.0189 0.3548
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0045 0.0128 0.0732
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.016 0.0913
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0074 0.0274 0.0666
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0055 0.1636
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0064 0.0223 0.0459
Giardia lamblia Kinase, AGC PKA 0.0064 0.0223 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.029 0.166
Echinococcus granulosus protein kinase c epsilon type 0.0073 0.0269 0.0652
Brugia malayi Egg laying defective protein 4 0.0085 0.033 0.033
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0543 1
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.1744 1
Echinococcus multilocularis nervana 2 0.006 0.0203 0.0418
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0001 0.5
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0051 0.0157 0.2874
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0126 0.0721
Entamoeba histolytica PH domain containing protein kinase, putative 0.0066 0.0234 0.0566
Schistosoma mansoni serine/threonine-protein kinase 0.0066 0.0234 0.0567
Leishmania major cathepsin L-like protease 0.002 0.0003 0.0013
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0045 0.0128 0.0263
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0174 0.0994
Entamoeba histolytica protein kinase, putative 0.0127 0.0543 0.1322
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.026 0.063
Leishmania major cysteine peptidase A (CPA) 0.002 0.0003 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0217 0.1238
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.006 0.0203 0.0418
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0045 0.0128 0.5733
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0055 0.2419
Plasmodium falciparum cysteine proteinase falcipain 3 0.002 0.0003 0.0066
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.485 1
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.016 0.0913
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.029 0.166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1998 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0229 0.0556
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0045 0.0128 0.0263
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Loa Loa (eye worm) AGC/PKA protein kinase 0.0045 0.0128 0.0125
Trichomonas vaginalis serine/threonine-protein kinase ypk, putative 0.0048 0.0146 0.2676
Echinococcus multilocularis serine threonine protein kinase 0.0065 0.0229 0.0472
Entamoeba histolytica protein kinase 2, putative 0.0064 0.0223 0.054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0229 0.0556
Echinococcus multilocularis rac serine:threonine kinase 0.0066 0.0234 0.0481
Leishmania major cathepsin L-like protease 0.002 0.0003 0.0013
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0003 0.004
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0128 0.031
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0066 0.0234 0.1338
Echinococcus granulosus cathepsin l1 0.002 0.0003 0.0005
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.0773 0.4431
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0065 0.0229 0.0227
Echinococcus granulosus protein kinase C gamma type 0.0065 0.0229 0.0556
Plasmodium falciparum glutathione reductase 0.0057 0.0189 0.5731
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0003 0.0013
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Schistosoma mansoni serine/threonine protein kinase 0.0085 0.033 0.08
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0003 0.004
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0174 0.0994
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0018 0.0102
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0126 0.5647
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0559 0.6411
Echinococcus granulosus nervana 2 0.006 0.0203 0.0493
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0126 0.0721
Trichomonas vaginalis AGC family protein kinase 0.011 0.0455 0.8373
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0632 0.7254
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0126 0.0719
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0064 0.0223 0.1277
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.0274 0.0564
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.1744 1
Schistosoma mansoni inositol monophosphatase 0.0045 0.0126 0.0305
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.016 0.0913
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0073 0.0269 0.0553
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0001 0.0001
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0041 0.0108 0.0222
Echinococcus granulosus nervana 2 0.006 0.0203 0.0493
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0045 0.0128 0.031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0051 0.0157 0.2874
Brugia malayi Cathepsin L-like precursor 0.002 0.0003 0.0003
Echinococcus multilocularis protein kinase c epsilon type 0.0073 0.0269 0.0553
Loa Loa (eye worm) AGC/NDR protein kinase 0.0065 0.0229 0.0227
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0126 0.2313
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0126 0.0302
Echinococcus granulosus serine:threonine protein kinase N2 0.0065 0.0229 0.0556
Entamoeba histolytica PH domain containing protein kinase, putative 0.0047 0.0139 0.0333
Schistosoma mansoni jumonji domain containing protein 0.0071 0.026 0.063
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0065 0.0229 0.0556
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.0872 1
Echinococcus granulosus serine/threonine protein kinase 0.0066 0.0234 0.0567
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0085 0.033 0.6191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0003 0.0005
Echinococcus multilocularis rho associated protein kinase 0.0645 0.316 0.6515
Loa Loa (eye worm) inositol-1 0.0045 0.0126 0.0123
Leishmania major cathepsin L-like protease 0.002 0.0003 0.0013
Loa Loa (eye worm) AGC/AKT protein kinase 0.0127 0.0543 0.054
Trichomonas vaginalis AGC family protein kinase 0.0127 0.0543 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0126 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0269 0.0652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Trichomonas vaginalis AGC family protein kinase 0.0112 0.0465 0.8571
Loa Loa (eye worm) hypothetical protein 0.0063 0.0218 0.0216
Echinococcus granulosus cGMP dependent protein kinase 0.0085 0.033 0.08
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0126 0.0259
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.0274 0.3143
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0018 0.0102
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0003 0.0005
Loa Loa (eye worm) AGC/PKG protein kinase 0.0085 0.033 0.0327
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0065 0.0229 0.0472
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0632 0.7254
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0055 0.1636
Brugia malayi jmjC domain containing protein 0.0071 0.026 0.026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0126 0.0719
Echinococcus granulosus Glutaredoxin protein 5 0.006 0.0203 0.0493
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Echinococcus granulosus rho-associated protein kinase 1 0.0645 0.316 0.7684
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0227 0.0224
Echinococcus granulosus cGMP dependent protein kinase 1 0.0085 0.033 0.08
Brugia malayi Hr1 repeat family protein 0.0065 0.0229 0.0229
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0065 0.0229 0.0556
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0045 0.0128 0.031
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0052
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0126 0.0306
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0126 0.236
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0073 0.0269 0.0266
Schistosoma mansoni serine/threonine protein kinase 0.0645 0.316 0.7684
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0065 0.0229 0.0556
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Echinococcus multilocularis nervana 2 0.006 0.0203 0.0418
Onchocerca volvulus 0.0645 0.316 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0189 0.0389
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0055 0.0309
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Onchocerca volvulus 0.0063 0.0218 0.0683
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0018 0.0016
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0018 0.0037
Echinococcus granulosus cGMP dependent protein kinase 1 0.0085 0.033 0.08
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Mycobacterium ulcerans hypothetical protein 0.0192 0.0872 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0003 0.004
Brugia malayi glutathione reductase 0.0057 0.0189 0.0189
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0157 0.2874
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0229 0.0556
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0126 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0018 0.0102
Plasmodium falciparum cGMP-dependent protein kinase 0.0085 0.033 1
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0045 0.0128 0.031
Brugia malayi Protein kinase domain containing protein 0.011 0.0455 0.0455
Echinococcus granulosus serine threonine protein kinase nrc 0.0064 0.0223 0.0541
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0003 0.0005
Leishmania major cathepsin L-like protease 0.0077 0.029 0.166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.0003 0.004
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.029 0.166
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0146 0.2676
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.016 0.0913
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0018 0.0204
Brugia malayi hypothetical protein 0.003 0.0055 0.0055
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.0274 0.0666
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0559 0.6411
Brugia malayi Protein kinase domain containing protein 0.0065 0.0229 0.0229
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0003 0.0005
Trypanosoma brucei unspecified product 0.0023 0.0018 0.0102
Schistosoma mansoni inositol monophosphatase 0.0045 0.0126 0.0305
Entamoeba histolytica hypothetical protein 0.0828 0.4088 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0045 0.0128 0.2401
Brugia malayi Cathepsin L-like precursor 0.002 0.0003 0.0003
Schistosoma mansoni atypical protein kinase C 0.0073 0.0269 0.0652
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.029 0.166
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0085 0.033 0.0679
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0093 0.1731

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 23.95 um PUBCHEM_BIOASSAY: TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists. (Class of assay: confirmatory) [Related pubchem assays: 1297, 1032 ] ChEMBL. No reference
EC50 (binding) = 27.75 uM PUBCHEM_BIOASSAY: TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1300, AID1808, AID504735, AID631] ChEMBL. No reference
EC50 (functional) > 79.37 um PUBCHEM_BIOASSAY: TR-FRET dose response biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPAR gamma): non-selective agonists. (Class of assay: confirmatory) [Related pubchem assays: 1301 (Confirmation screen.), 1048 (Primary screen.)] ChEMBL. No reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 6.3096 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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