Detailed information for compound 1378874

Basic information

Technical information
  • TDR Targets ID: 1378874
  • Name: N-(5-ethyl-1,3,4-thiadiazol-2-yl)-1-[2-(4-flu orophenyl)ethyl]-5-oxopyrrolidine-3-carboxami de
  • MW: 362.422 | Formula: C17H19FN4O2S
  • H donors: 1 H acceptors: 4 LogP: 1.94 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nnc(s1)NC(=O)C1CC(=O)N(C1)CCc1ccc(cc1)F
  • InChi: 1S/C17H19FN4O2S/c1-2-14-20-21-17(25-14)19-16(24)12-9-15(23)22(10-12)8-7-11-3-5-13(18)6-4-11/h3-6,12H,2,7-10H2,1H3,(H,19,21,24)
  • InChiKey: AMALQQCMOBLLHV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-ethyl-1,3,4-thiadiazol-2-yl)-1-[2-(4-fluorophenyl)ethyl]-5-oxo-pyrrolidine-3-carboxamide
  • N-(5-ethyl-1,3,4-thiadiazol-2-yl)-1-[2-(4-fluorophenyl)ethyl]-5-oxo-3-pyrrolidinecarboxamide
  • N-(5-ethyl-1,3,4-thiadiazol-2-yl)-1-[2-(4-fluorophenyl)ethyl]-5-keto-pyrrolidine-3-carboxamide
  • ASN 13780942
  • STK227238

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Trichomonas vaginalis conserved hypothetical protein 0.011 0.103 1
Echinococcus granulosus semaphorin 1A 0.0071 0.0631 0.1097
Loa Loa (eye worm) hypothetical protein 0.011 0.103 0.1495
Loa Loa (eye worm) hypothetical protein 0.006 0.0517 0.075
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.013 0.0189
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis natriuretic peptide receptor 1 0.0011 0.0007 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1677 0.4583
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0022 0.0032
Leishmania major protein kinase, putative 0.0013 0.0034 0.0094
Brugia malayi A-kinase anchor protein 10, precursor 0.011 0.103 0.1495
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0022 0.0032
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0011 0.0007 0.0012
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0007 0.001
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Echinococcus granulosus tyrosine protein kinase ABL1 0.0011 0.0007 0.0012
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis regulator of G protein signaling 7 0.011 0.103 0.103
Onchocerca volvulus 0.0012 0.0022 0.0132
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Brugia malayi Tyrosine-protein kinase PR2 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus granulosus c src tyrosine kinase 0.0011 0.0007 0.0012
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0007 0.001
Onchocerca volvulus 0.0011 0.0007 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Entamoeba histolytica hypothetical protein 0.0031 0.0218 0.2118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni ap endonuclease 0.0023 0.013 0.0189
Onchocerca volvulus 0.0011 0.0007 0.0043
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0013 0.0034 0.06
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0022 0.0038
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Echinococcus multilocularis protein KINase family member (kin 25) 0.0011 0.0007 0.0007
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0022 0.0132
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0011 0.0007 0.0125
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Trypanosoma cruzi NIMA-related kinase, putative 0.0013 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0022 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0007 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.0071 0.0631 0.0916
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Echinococcus granulosus G protein coupled receptor kinase 1 0.041 0.4123 0.7163
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.008
Echinococcus multilocularis epidermal growth factor receptor 0.0011 0.0007 0.0007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.4993 0.4993
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Echinococcus granulosus regulator of G protein signaling 7 0.011 0.103 0.179
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.008
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0574 1
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) sema domain-containing protein 0.0071 0.0631 0.0916
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0013 0.0034 0.006
Loa Loa (eye worm) serine/threonine protein kinase 0.0011 0.0007 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0011 0.0007 0.001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Leishmania major protein kinase, putative 0.0013 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.008
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.008
Echinococcus granulosus tyrosine kinase 0.0011 0.0007 0.0012
Onchocerca volvulus 0.0011 0.0007 0.0043
Echinococcus granulosus regulator of G protein signaling 7 0.011 0.103 0.179
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0022 0.0038
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0011 0.0007 0.0007
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0011 0.0007 0.001
Echinococcus granulosus regulator of G protein signaling 3 0.011 0.103 0.179
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Schistosoma mansoni serine/threonine protein kinase 0.0678 0.689 1
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0022 0.0032
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0007 0.001
Schistosoma mansoni protein kinase 0.0011 0.0007 0.001
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0022 0.0022
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Entamoeba histolytica PH domain containing protein kinase, putative 0.0013 0.0027 0.0265
Schistosoma mansoni protein kinase 0.0011 0.0007 0.001
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.013 0.013
Echinococcus multilocularis transcription factor collier 0.0031 0.0218 0.0218
Leishmania major protein kinase, putative 0.0013 0.0027 0.0075
Echinococcus granulosus dnaJ subfamily B 0.0494 0.4993 0.8674
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.013 1
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus granulosus voltage gated potassium channel 0.001 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.011 0.103 1
Schistosoma mansoni serine/threonine protein kinase 0.052 0.5257 0.763
Echinococcus multilocularis G protein coupled receptor kinase 1 0.041 0.4123 0.4123
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0011 0.0007 0.007
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.011 0.103 1
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0239 0.2324
Echinococcus granulosus axis inhibition protein axin 0.011 0.103 0.179
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis tyrosine protein kinase Blk 0.0011 0.0007 0.0007
Echinococcus multilocularis MAM 0.0027 0.0179 0.0179
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0092 0.0134
Entamoeba histolytica protein kinase domain containing protein 0.0013 0.0034 0.0334
Loa Loa (eye worm) RGS-3 protein 0.011 0.103 0.1495
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0031 0.0218 0.2118
Onchocerca volvulus 0.0011 0.0007 0.0043
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0013 0.0027 0.0075
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0541 0.1478
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0011 0.0007 0.0012
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0011 0.0007 0.0007
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0013 0.0027 0.0075
Brugia malayi Sema domain containing protein 0.0071 0.0631 0.0916
Loa Loa (eye worm) hypothetical protein 0.0171 0.1656 0.2404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0356 0.0356
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0022 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0013 0.0027 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0254 0.0368
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0092 0.0134
Loa Loa (eye worm) sema domain-containing protein 0.0071 0.0631 0.0916
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0031 0.0218 0.2118
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0011 0.0007 0.0012
Brugia malayi bone morphogenetic protein type 1 receptor 0.0011 0.0007 0.001
Echinococcus granulosus regulator of G protein signaling 3 0.011 0.103 0.179
Loa Loa (eye worm) hypothetical protein 0.011 0.103 0.1495
Echinococcus multilocularis axis inhibition protein axin 0.011 0.103 0.103
Schistosoma mansoni protein tyrosine kinase 0.0011 0.0007 0.001
Echinococcus multilocularis GPCR, family 2 0.0019 0.0092 0.0092
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.026
Echinococcus granulosus epidermal growth factor receptor 0.0011 0.0007 0.0012
Echinococcus granulosus serine/threonine protein kinase 0.0013 0.0027 0.0047
Schistosoma mansoni hypothetical protein 0.0041 0.0321 0.0465
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.013 1
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Echinococcus granulosus tyrosine kinase 0.0011 0.0007 0.0012
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0425 0.1162
Echinococcus multilocularis receptor type guanylyl cyclase 0.0011 0.0007 0.0007
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0007 0.007
Entamoeba histolytica hypothetical protein 0.0031 0.0218 0.2118
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0015 0.0055 0.008
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Schistosoma mansoni hypothetical protein 0.0019 0.0092 0.0134
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Brugia malayi Fibronectin type III domain containing protein 0.0015 0.0055 0.008
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0011 0.0007 0.0043
Brugia malayi C-terminal src kinase protein 1 0.0011 0.0007 0.001
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0568 0.5756 0.8354
Entamoeba histolytica tyrosin kinase, putative 0.0011 0.0007 0.007
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.013 0.5
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus multilocularis protein kinase 0.0011 0.0007 0.0007
Loa Loa (eye worm) plexin A 0.0202 0.1978 0.2871
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Entamoeba histolytica PH domain containing protein kinase, putative 0.0013 0.0027 0.0265
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Brugia malayi SH2 domain containing protein 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis regulator of G protein signaling 7 0.011 0.103 0.103
Brugia malayi DNA-binding protein LAG-1 0.0031 0.0218 0.0317
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0022 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0007 0.001
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0678 0.689 1
Echinococcus multilocularis FL cytokine receptor 0.0011 0.0007 0.0007
Onchocerca volvulus 0.0011 0.0007 0.0043
Leishmania major folate/biopterin transporter, putative 0.0013 0.0027 0.0075
Brugia malayi hypothetical protein 0.011 0.103 0.1495
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0007 0.0012
Echinococcus granulosus tyrosine protein kinase Src64B 0.0011 0.0007 0.0012
Echinococcus multilocularis tyrosine protein kinase csk 0.0011 0.0007 0.0007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) TK/ALK protein kinase 0.024 0.2369 0.3438
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0013 0.0027 0.0075
Brugia malayi Furin-like cysteine rich region family protein 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0631 0.0916
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0002 0.0004
Schistosoma mansoni nephrin 0.0015 0.0055 0.008
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0011 0.0007 0.001
Entamoeba histolytica hypothetical protein 0.0013 0.0027 0.0265
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0022 0.0032
Entamoeba histolytica hypothetical protein 0.0043 0.0344 0.3342
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0022 0.0032
Brugia malayi Receptor family ligand binding region containing protein 0.0011 0.0007 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.013 0.1265
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Echinococcus multilocularis tyrosine protein kinase Srms 0.0011 0.0007 0.0007
Schistosoma mansoni cpg binding protein 0.0035 0.0254 0.0368
Loa Loa (eye worm) TK/Met protein kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) TK/ROR protein kinase 0.0011 0.0007 0.001
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.011 0.103 0.1495
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni z-protein (S1r protein) 0.011 0.103 0.1495
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0344 0.0598
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Echinococcus multilocularis cpg binding protein 0.0037 0.0274 0.0274
Entamoeba histolytica protein kinase, putative 0.0013 0.0027 0.0265
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0011 0.0007 0.007
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Entamoeba histolytica PH domain containing protein kinase, putative 0.0013 0.0027 0.0265
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0022 0.0022
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0011 0.0007 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Brugia malayi nuclear hormone receptor 0.0012 0.0022 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Onchocerca volvulus 0.0035 0.0254 0.1532
Schistosoma mansoni ephrin receptor 0.0011 0.0007 0.001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0022 0.0032
Leishmania major protein kinase, putative 0.0011 0.0007 0.002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.013 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Leishmania major serine/threonine-protein kinase a, putative 0.0013 0.0027 0.0075
Onchocerca volvulus 0.0011 0.0007 0.0043
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.011 0.103 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0022 0.0032
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0568 0.5756 0.8354
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.008
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis protein kinase 0.0011 0.0007 0.0007
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0011 0.0007 0.007
Echinococcus granulosus tyrosine protein kinase csk 0.0011 0.0007 0.0012
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Echinococcus granulosus natriuretic peptide receptor 1 0.0011 0.0007 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Entamoeba histolytica receptor protein kinase, putative 0.0011 0.0007 0.007
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) SRC-1 0.0011 0.0007 0.001
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0011 0.0007 0.001
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0011 0.0007 0.007
Onchocerca volvulus 0.0011 0.0007 0.0043
Schistosoma mansoni protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0344 0.05
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.052 0.5257 0.763
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0218 0.2118
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0011 0.0007 0.001
Echinococcus granulosus cpg binding protein 0.0037 0.0274 0.0476
Entamoeba histolytica protein kinase, putative 0.0013 0.0027 0.0265
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0031 0.0218 0.2118
Echinococcus granulosus tyrosine protein kinase csk 0.0011 0.0007 0.0012
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.013 0.0356
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.013 1
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Echinococcus multilocularis tyrosine kinase 0.0011 0.0007 0.0007
Trypanosoma brucei rac serine-threonine kinase, putative 0.0013 0.0027 0.0075
Schistosoma mansoni semaphorin 5-related 0.0071 0.0631 0.0916
Echinococcus granulosus retinal guanylyl cyclase 2 0.0011 0.0007 0.0012
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0425 0.1162
Brugia malayi SRC-1 0.0011 0.0007 0.001
Schistosoma mansoni protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica p21-activated kinase 0.0013 0.0027 0.0265
Onchocerca volvulus 0.0011 0.0007 0.0043
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Trypanosoma cruzi protein kinase, putative 0.0011 0.0007 0.002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.0239 0.2324
Trichomonas vaginalis conserved hypothetical protein 0.011 0.103 1
Brugia malayi Raf kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Schistosoma mansoni hypothetical protein 0.0071 0.0631 0.0916
Echinococcus granulosus defective proboscis extension response 0.0015 0.0055 0.0096
Echinococcus multilocularis epidermal growth factor receptor 0.0011 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Echinococcus granulosus beta-adrenergic receptor kinase 0.052 0.5257 0.9133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.008
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus granulosus Regulator of G protein signaling 20 0.011 0.103 0.179
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.007
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.011 0.103 0.103
Trypanosoma brucei protein kinase, putative 0.0013 0.0027 0.0075
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Entamoeba histolytica hypothetical protein 0.011 0.103 1
Brugia malayi Protein kinase domain containing protein 0.024 0.237 0.3439
Trypanosoma cruzi protein kinase, putative 0.0011 0.0007 0.002
Brugia malayi PXA domain containing protein 0.011 0.103 0.1495
Loa Loa (eye worm) PXA domain-containing protein 0.011 0.103 0.1495
Leishmania major hypothetical protein, conserved 0.0011 0.0007 0.002
Echinococcus multilocularis hypothetical protein 0.0071 0.0631 0.0631
Schistosoma mansoni serine/threonine-protein kinase 0.0013 0.0027 0.004
Echinococcus granulosus transcription factor collier 0.0031 0.0218 0.0379
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0013 0.0034 0.0034
Echinococcus granulosus semaphorin 5B 0.0071 0.0631 0.1097
Echinococcus granulosus retinal guanylyl cyclase 2 0.0011 0.0007 0.0012
Brugia malayi hypothetical protein 0.0015 0.0055 0.008
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0011 0.0007 0.001
Echinococcus multilocularis activin receptor type 0.0013 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.011 0.103 0.1495
Brugia malayi hypothetical protein 0.0043 0.0344 0.05
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0218 0.2118
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0022 0.0032
Trypanosoma brucei Flagellum attachment zone protein 20 0.0011 0.0007 0.002
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Echinococcus granulosus axis inhibition protein axin 0.011 0.103 0.179
Schistosoma mansoni serine/threonine-protein kinase 0.0013 0.0027 0.004
Echinococcus granulosus neuroglian 0.0015 0.0055 0.0096
Entamoeba histolytica cysteine surface protein, putative 0.0011 0.0007 0.007
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.1878 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0007 0.001
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0011 0.0007 0.0007
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0011 0.0007 0.0012
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0011 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0022 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0011 0.0007 0.001
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.013 0.1265
Entamoeba histolytica hypothetical protein 0.0043 0.0344 0.3342
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0011 0.0007 0.0012
Loa Loa (eye worm) TK/EGFR protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Brugia malayi Probable exocyst complex component Sec5 0.0031 0.0218 0.0317
Schistosoma mansoni protein kinase 0.0013 0.0034 0.005
Onchocerca volvulus 0.0027 0.0179 0.108
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Schistosoma mansoni cpg binding protein 0.0037 0.0274 0.0398
Entamoeba histolytica tyrosin kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0011 0.0007 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0022 0.0032
Entamoeba histolytica hypothetical protein 0.011 0.103 1
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0011 0.0007 0.0012
Schistosoma mansoni hypothetical protein 0.0494 0.4993 0.7246
Toxoplasma gondii STE kinase 0.0011 0.0007 0.0125
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni hypothetical protein 0.0027 0.0179 0.026
Echinococcus multilocularis c src tyrosine kinase 0.0011 0.0007 0.0007
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Toxoplasma gondii protein kinase domain-containing protein 0.0013 0.0027 0.0475
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0013 0.0027 0.0075
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Echinococcus granulosus expressed protein 0.011 0.103 0.179
Echinococcus granulosus protein tyrosine kinase 0.0011 0.0007 0.0012
Echinococcus granulosus activated cdc42 kinase 1 0.0011 0.0007 0.0012
Echinococcus multilocularis plexin a4 0.0202 0.1978 0.1978
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica tyrosin kinase, putative 0.0042 0.0329 0.3198
Onchocerca volvulus 0.0011 0.0007 0.0043
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0655 0.0951
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0013 0.0027 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Entamoeba histolytica protein kinase, putative 0.0013 0.0027 0.0265
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.011 0.103 0.1495
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0011 0.0007 0.0007
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus multilocularis kinase suppressor of Ras 1 0.0011 0.0007 0.0007
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0031 0.0218 0.2118
Echinococcus granulosus plexin a4 0.0202 0.1978 0.3437
Echinococcus multilocularis raf serine:threonine protein kinase 0.0011 0.0007 0.0007
Echinococcus multilocularis expressed protein 0.011 0.103 0.103
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Schistosoma mansoni hypothetical protein 0.0071 0.0631 0.0916
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0013 0.0027 0.0075
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.3659 1
Plasmodium falciparum protein kinase, putative 0.0013 0.0034 0.2643
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0011 0.0007 0.0012
Onchocerca volvulus 0.0011 0.0007 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Plasmodium vivax tyrosine kinase-like protein, putative 0.0011 0.0007 0.055
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0007 0.0007
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0022 0.0032
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0034 0.0094
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0425 0.1162
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0007 0.0012
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0568 0.5756 0.8354
Trichomonas vaginalis protein tyrosine kinase, putative 0.0011 0.0007 0.007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.013 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0022 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0568 0.5756 0.5756
Entamoeba histolytica receptor protein kinase, putative 0.0011 0.0007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.007
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0022 0.0022
Schistosoma mansoni serine/threonine RGC 0.0011 0.0007 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0022 0.0038
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1677 0.4583
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) TK/DDR protein kinase 0.0011 0.0007 0.001
Brugia malayi Tyrosine-protein kinase abl-1 0.0011 0.0007 0.001
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0022 0.0032
Loa Loa (eye worm) TK/CSK protein kinase 0.0011 0.0007 0.001
Schistosoma mansoni regulator of G protein signaling 0.011 0.103 0.1495
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Loa Loa (eye worm) hypothetical protein 0.0071 0.0631 0.0916
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Trichomonas vaginalis AGC family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0344 0.0344
Brugia malayi protein-tyrosine kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0011 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Schistosoma mansoni regulator of G protein signaling 0.011 0.103 0.1495
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis beta adrenergic receptor kinase 0.052 0.5257 0.5257
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0022 0.0038
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0022 0.0032
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.026
Brugia malayi regulator of G-protein signaling rgs-7 0.011 0.103 0.1495
Echinococcus granulosus tyrosine protein kinase Srms 0.0011 0.0007 0.0012
Echinococcus multilocularis ephrin type A receptor 4 A 0.0011 0.0007 0.0007
Brugia malayi hypothetical protein 0.0011 0.0007 0.001
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0013 0.0027 0.0265
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0011 0.0007 0.0007
Brugia malayi steroid hormone receptor 0.0012 0.0022 0.0032
Onchocerca volvulus 0.0011 0.0007 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.011 0.103 1
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0022 0.0038
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Echinococcus multilocularis tyrosine protein kinase csk 0.0011 0.0007 0.0007
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0011 0.0007 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.013 0.0356
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0022 0.0022
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.011 0.103 0.1495
Echinococcus multilocularis Immunoglobulin 0.0015 0.0055 0.0055
Brugia malayi PXA domain containing protein 0.011 0.103 0.1495
Entamoeba histolytica ankyrin repeat protein 0.0011 0.0007 0.007
Brugia malayi Plexin repeat family protein 0.0171 0.1656 0.2404
Entamoeba histolytica protein kinase, putative 0.0013 0.0027 0.0265
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.013 0.0356
Echinococcus granulosus tyrosine protein kinase Lyn 0.0013 0.0034 0.006
Plasmodium falciparum tyrosine kinase-like protein 0.0011 0.0007 0.055
Echinococcus multilocularis neuroglian 0.0015 0.0055 0.0055
Onchocerca volvulus 0.0011 0.0007 0.0043
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1677 0.4583
Onchocerca volvulus 0.0027 0.0179 0.108
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0678 0.689 1
Echinococcus multilocularis regulator of G protein signaling 3 0.011 0.103 0.103
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0011 0.0007 0.007
Echinococcus multilocularis semaphorin 5B 0.0071 0.0631 0.0631
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0011 0.0007 0.0007
Schistosoma mansoni protein kinase 0.0011 0.0007 0.001
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0013 0.0027 0.0075
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0215 0.0312
Echinococcus multilocularis regulator of G protein signaling 3 0.011 0.103 0.103
Schistosoma mansoni regulator of G protein signaling 0.011 0.103 0.1495
Echinococcus granulosus tyrosine protein kinase HCK 0.0011 0.0007 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trichomonas vaginalis STE family protein kinase 0.0011 0.0007 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0013 0.0027 0.0075
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0356 0.0619
Loa Loa (eye worm) hypothetical protein 0.0071 0.0631 0.0916
Plasmodium falciparum tyrosine kinase-like protein 0.0011 0.0007 0.055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0356 0.0517
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0011 0.0007 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0022 0.0032
Onchocerca volvulus 0.0011 0.0007 0.0043
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0264 0.0383
Echinococcus granulosus fibroblast growth factor receptor 4 0.0011 0.0007 0.0012
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Schistosoma mansoni regulator of G protein signaling 0.011 0.103 0.1495
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0011 0.0007 0.0007
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0011 0.0007 0.0012
Echinococcus granulosus retinal guanylyl cyclase 2 0.0011 0.0007 0.0012
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0034 0.0094
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.011 0.103 0.179
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0002 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0218 0.2118
Entamoeba histolytica cell surface protease gp63, putative 0.0031 0.0218 0.2118
Loa Loa (eye worm) TK/ABL protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0011 0.0007 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus granulosus tyrosine protein kinase pr2 0.0011 0.0007 0.0012
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0568 0.5756 1
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Trypanosoma brucei protein kinase, putative 0.0013 0.0034 0.0094
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0002 0.0004
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis tyrosine protein kinase 0.0011 0.0007 0.0007
Toxoplasma gondii exonuclease III APE 0.0023 0.013 0.227
Trichomonas vaginalis conserved hypothetical protein 0.011 0.103 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Plasmodium vivax protein kinase, putative 0.0011 0.0007 0.055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0022 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0218 0.2118
Entamoeba histolytica PH domain containing protein kinase, putative 0.0013 0.0027 0.0265
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0011 0.0007 0.001
Onchocerca volvulus Tyrosine kinase homolog 0.0011 0.0007 0.0043
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Onchocerca volvulus 0.0011 0.0007 0.0043
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0022 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0218 0.2118
Schistosoma mansoni hypothetical protein 0.0099 0.0921 0.1336
Schistosoma mansoni fibrocystin l 0.0031 0.0218 0.0317
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0022 0.0032
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0011 0.0007 0.001
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0011 0.0007 0.0012
Brugia malayi ecdysteroid receptor 0.0012 0.0022 0.0032
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0013 0.0027 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0218 0.2118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0218 0.0317
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0022 0.0022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3659 1
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis protein tyrosine kinase 0.0011 0.0007 0.0007
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0011 0.0007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0218 0.2118
Echinococcus multilocularis tyrosine protein kinase csk 0.0011 0.0007 0.0007
Toxoplasma gondii protein kinase domain-containing protein 0.0011 0.0007 0.0125
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0011 0.0007 0.001
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0022 0.0038
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.013 0.0189
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0011 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.007
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus granulosus tyrosine protein kinase Blk 0.0011 0.0007 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Schistosoma mansoni hypothetical protein 0.0019 0.0092 0.0134
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.011 0.103 0.1495
Schistosoma mansoni hypothetical protein 0.0043 0.0344 0.05
Echinococcus multilocularis tyrosine protein kinase pr2 0.0011 0.0007 0.0007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.3659 1
Echinococcus multilocularis exocyst complex component 2 0.0031 0.0218 0.0218
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0013 0.0027 0.2094
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Schistosoma mansoni hypothetical protein 0.0031 0.0218 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0022 0.0032
Echinococcus granulosus GPCR family 2 0.0019 0.0092 0.0161
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.026
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0011 0.0007 0.0007
Echinococcus granulosus tyrosine protein kinase csk 0.0011 0.0007 0.0012
Schistosoma mansoni hypothetical protein 0.0019 0.0092 0.0134
Loa Loa (eye worm) hypothetical protein 0.011 0.103 0.1495
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0011 0.0007 0.002
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0013 0.0027 0.0075
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0005 0.0008
Entamoeba histolytica tyrosin kinase, putative 0.0011 0.0007 0.007
Brugia malayi hypothetical protein 0.0071 0.0631 0.0916
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trypanosoma cruzi Protein kinase B 0.0013 0.0027 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0218 0.0317
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Entamoeba histolytica hypothetical protein, conserved 0.0011 0.0007 0.007
Echinococcus granulosus Immunoglobulin 0.0015 0.0055 0.0096
Brugia malayi Regulator of G protein signaling domain containing protein 0.011 0.103 0.1495
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0007 0.007
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Echinococcus multilocularis insulin receptor 0.0011 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.011 0.103 1
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0011 0.0007 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0356 0.0517
Loa Loa (eye worm) AGC/AKT protein kinase 0.0013 0.0027 0.004
Entamoeba histolytica ankyrin repeat protein 0.0011 0.0007 0.007
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0011 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0031 0.0218 0.0317
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0517 0.075
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0425 0.1162
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Echinococcus granulosus receptor type guanylyl cyclase 0.0011 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.011 0.103 0.1495
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.013 0.1265
Schistosoma mansoni cpg binding protein 0.0037 0.0274 0.0398
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0007 0.0007
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0026 0.0166 0.0241
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0011 0.0007 0.0007
Echinococcus multilocularis tyrosine protein kinase HCK 0.0011 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0022 0.0032
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Onchocerca volvulus 0.0071 0.0631 0.3813
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0356 0.0517
Echinococcus granulosus roundabout 2 0.0015 0.0055 0.0096
Brugia malayi hypothetical protein 0.0011 0.0007 0.001
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica hypothetical protein 0.0031 0.0218 0.2118
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0092 0.0092
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0011 0.0007 0.001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0356 0.0619
Schistosoma mansoni protein kinase 0.0011 0.0007 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0055 0.008
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0022 0.0132
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Echinococcus multilocularis rac serine:threonine kinase 0.0013 0.0027 0.0027
Schistosoma mansoni protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0011 0.0007 0.001
Plasmodium falciparum protein kinase, putative 0.0011 0.0007 0.055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0022 0.0032
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0099 0.0921 0.1336
Echinococcus granulosus kinase suppressor of Ras 1 0.0011 0.0007 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0022 0.0022
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Echinococcus granulosus tyrosine protein kinase 0.0011 0.0007 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0517 0.075
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0022 0.0032
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0011 0.0007 0.001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Schistosoma mansoni coup transcription factor 0.0012 0.0022 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Schistosoma mansoni plexin 0.0099 0.0921 0.1336
Brugia malayi IPT/TIG domain containing protein 0.0031 0.0218 0.0317
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.0201 0.1975 0.2866
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0011 0.0007 0.0012
Echinococcus granulosus raf serine:threonine protein kinase 0.0011 0.0007 0.0012
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0011 0.0007 0.0043
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0321 0.0465
Loa Loa (eye worm) TK/ACK protein kinase 0.0011 0.0007 0.001
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0022 0.0038
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0013 0.0027 0.0475
Brugia malayi CXXC zinc finger family protein 0.0035 0.0254 0.0368
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0264 0.0458
Brugia malayi hypothetical protein 0.0011 0.0007 0.001
Plasmodium falciparum protein kinase, putative 0.0011 0.0007 0.055
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0264 0.0383
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Mycobacterium ulcerans hypothetical protein 0.0192 0.1878 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0022 0.0038
Schistosoma mansoni protein kinase 0.0013 0.0034 0.005
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0011 0.0007 0.0007
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0007 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0022 0.0038
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0055 0.0096
Brugia malayi hypothetical protein 0.0071 0.0631 0.0916
Schistosoma mansoni hypothetical protein 0.0031 0.0218 0.0317
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0013 0.0027 0.0265
Loa Loa (eye worm) TK/EPH protein kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0218 0.0317
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0092 0.0161
Schistosoma mansoni protein kinase 0.0013 0.0034 0.005
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Brugia malayi hypothetical protein 0.0027 0.0179 0.026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0022 0.0032
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Schistosoma mansoni tyrosine protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0011 0.0007 0.0007
Entamoeba histolytica protein kinase, putative 0.0013 0.0027 0.0265
Echinococcus multilocularis heat shock protein 70 0.0011 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Brugia malayi Protein kinase domain containing protein 0.0013 0.0027 0.004
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Echinococcus multilocularis tyrosine protein kinase shark 0.0011 0.0007 0.0007
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Echinococcus granulosus epidermal growth factor receptor 0.0011 0.0007 0.0012
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.008
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0022 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0022 0.0032
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0034 0.0094
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0092 0.0092
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0022 0.0032
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0022 0.0032
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0092 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0264 0.0264
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0013 0.0027 0.0075
Entamoeba histolytica hypothetical protein 0.0031 0.0218 0.2118
Brugia malayi SH2 domain containing protein 0.0011 0.0007 0.001
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0011 0.0007 0.0012
Echinococcus granulosus exocyst complex component 2 0.0031 0.0218 0.0379
Trichomonas vaginalis protein kinase atn1, putative 0.0011 0.0007 0.007
Toxoplasma gondii protein kinase 0.0011 0.0007 0.0125
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0011 0.0007 0.001
Echinococcus multilocularis roundabout 2 0.0015 0.0055 0.0055
Loa Loa (eye worm) protein kinase domain-containing protein 0.0011 0.0007 0.001
Onchocerca volvulus 0.0171 0.1656 1
Brugia malayi regulator of G-protein signaling egl-10 0.011 0.103 0.1495
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0022 0.0132
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0517 0.075
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus multilocularis regulator of G protein signaling 0.011 0.103 0.103
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0011 0.0007 0.0012
Schistosoma mansoni plexin 0.0171 0.1656 0.2404
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0631 0.0916
Brugia malayi Sema domain containing protein 0.0071 0.0631 0.0916
Schistosoma mansoni ap endonuclease 0.0023 0.013 0.0189
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0011 0.0007 0.001
Toxoplasma gondii hypothetical protein 0.0059 0.0503 0.8763
Entamoeba histolytica PH domain containing protein kinase, putative 0.0013 0.0027 0.0265
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.011 0.103 0.1495
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Entamoeba histolytica serine/threonine kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0092 0.0134
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Echinococcus granulosus activin receptor type 0.0013 0.0034 0.006
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0013 0.0027 0.0075
Echinococcus granulosus tyrosine protein kinase shark 0.0011 0.0007 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0022 0.0032
Brugia malayi nuclear receptor NHR-88 0.0012 0.0022 0.0032
Onchocerca volvulus 0.0011 0.0007 0.0043
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Echinococcus multilocularis axis inhibition protein axin 0.011 0.103 0.103
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0092 0.0161
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase domain containing protein 0.0042 0.0329 0.3198
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0015 0.0055 0.008
Brugia malayi Guanylyl cyclase protein 23 0.0011 0.0007 0.001
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0011 0.0007 0.007
Schistosoma mansoni regulator of G protein signaling 0.011 0.103 0.1495
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0011 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0013 0.0027 0.0265
Brugia malayi hypothetical protein 0.011 0.103 0.1495
Entamoeba histolytica hypothetical protein 0.0043 0.0344 0.3342
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0007 0.0012
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni protein kinase 0.0011 0.0007 0.001
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0011 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0022 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0015 0.0055 0.0055
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0004
Echinococcus granulosus protein kinase 0.0011 0.0007 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0026 0.0166 0.0241
Entamoeba histolytica protein kinase, putative 0.0013 0.0027 0.0265
Brugia malayi Regulator of G protein signaling domain containing protein 0.011 0.103 0.1495
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Echinococcus granulosus activated cdc42 kinase 1 0.0011 0.0007 0.0012
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.008
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0022 0.0032
Echinococcus multilocularis integrin linked protein kinase 0.0011 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0043 0.0344 0.3342
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni axis inhibition protein axin 0.011 0.103 0.1495
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Echinococcus granulosus ephrin type A receptor 4 A 0.0011 0.0007 0.0012
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0297 0.0432
Echinococcus multilocularis activated cdc42 kinase 1 0.0011 0.0007 0.0007
Plasmodium vivax tyrosine kinase-like protein, putative 0.0011 0.0007 0.055
Schistosoma mansoni vesicular amine transporter 0.0018 0.0079 0.0115
Brugia malayi plexin A 0.0202 0.1978 0.2871
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Brugia malayi Protein kinase domain containing protein 0.0011 0.0007 0.001
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0011 0.0007 0.0125
Echinococcus granulosus tyrosine protein kinase Src42A 0.0011 0.0007 0.0012
Echinococcus multilocularis Immunoglobulin 0.0015 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0019 0.0092 0.0134
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0356 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0022 0.0032
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0007 0.001
Echinococcus multilocularis tyrosine protein kinase csk 0.0011 0.0007 0.0007
Schistosoma mansoni axis inhibition protein axin 0.011 0.103 0.1495
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0007 0.007
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0002 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.3659 1
Loa Loa (eye worm) TK/FAK protein kinase 0.0011 0.0007 0.001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0002 0.0004
Echinococcus granulosus twitchin 0.0018 0.0082 0.0143
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0007 0.001
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0011 0.0007 0.0007
Echinococcus granulosus MAM 0.0027 0.0179 0.0311
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0356 0.0517
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0011 0.0007 0.0007
Trichomonas vaginalis TK family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis transfer RNA-Thr 0.0011 0.0007 0.0007
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) hypothetical protein 0.0071 0.0631 0.0916
Loa Loa (eye worm) TK protein kinase 0.0011 0.0007 0.001
Schistosoma mansoni hypothetical protein 0.0027 0.0179 0.026
Schistosoma mansoni tyrosine kinase 0.0011 0.0007 0.001
Entamoeba histolytica protein kinase, putative 0.0013 0.0027 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0022 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0297 0.0432
Trypanosoma brucei Pseudokinase, putative 0.0011 0.0007 0.002
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0031 0.0218 0.2118
Schistosoma mansoni cell adhesion molecule 0.0015 0.0055 0.008
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Schistosoma mansoni ephrin receptor 0.0011 0.0007 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0007 0.0007
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0013 0.0027 0.0075
Loa Loa (eye worm) TK/INSR protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Echinococcus multilocularis Regulator of G protein signaling 20 0.011 0.103 0.103
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus granulosus integrin linked protein kinase 0.0011 0.0007 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0022 0.0032
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0011 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.001
Schistosoma mansoni serine/threonine protein kinase 0.052 0.5257 0.763
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0356 0.0517
Plasmodium falciparum calcium-dependent protein kinase 7 0.0013 0.0027 0.2094
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0027 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0022 0.0032
Loa Loa (eye worm) TK/RYK protein kinase 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0022 0.0032
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0007 0.0007
Brugia malayi integrin-linked kinase 0.0011 0.0007 0.001
Echinococcus multilocularis tyrosine protein kinase Abl 0.0011 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.0032
Entamoeba histolytica PH domain containing protein kinase, putative 0.0013 0.0027 0.0265
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0013 0.0027 0.0075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.013 0.0226
Echinococcus granulosus insulin receptor 0.0011 0.0007 0.0012
Entamoeba histolytica protein kinase domain containing protein 0.0011 0.0007 0.007
Entamoeba histolytica protein kinase, putative 0.0011 0.0007 0.007
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0011 0.0007 0.001
Entamoeba histolytica tyrosine kinase, putative 0.0011 0.0007 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0007 0.001
Trypanosoma cruzi NIMA-related kinase, putative 0.0013 0.0027 0.0075
Brugia malayi ephrin receptor 1 precursor 0.0011 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.0465
Echinococcus granulosus tyrosine kinase 0.0011 0.0007 0.0012
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0011 0.0007 0.001
Trichomonas vaginalis TKL family protein kinase 0.0011 0.0007 0.007
Echinococcus multilocularis tyrosine kinase 0.0011 0.0007 0.0007

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0423 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.