Detailed information for compound 1380565

Basic information

Technical information
  • TDR Targets ID: 1380565
  • Name: 3-(1-tert-butyl-3,4,6-trimethylpyrazolo[4,5-e ]pyridin-5-yl)-N-(4-fluorophenyl)propanamide
  • MW: 382.474 | Formula: C22H27FN4O
  • H donors: 1 H acceptors: 3 LogP: 4.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)F)CCc1c(C)nc2c(c1C)c(C)nn2C(C)(C)C
  • InChi: 1S/C22H27FN4O/c1-13-18(11-12-19(28)25-17-9-7-16(23)8-10-17)14(2)24-21-20(13)15(3)26-27(21)22(4,5)6/h7-10H,11-12H2,1-6H3,(H,25,28)
  • InChiKey: UBICQZXXGKAAKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(1-tert-butyl-3,4,6-trimethyl-pyrazolo[4,5-e]pyridin-5-yl)-N-(4-fluorophenyl)propanamide
  • 3-(1-tert-butyl-3,4,6-trimethyl-5-pyrazolo[4,5-e]pyridinyl)-N-(4-fluorophenyl)propanamide
  • 3-(1-tert-butyl-3,4,6-trimethyl-pyrazolo[4,5-e]pyridin-5-yl)-N-(4-fluorophenyl)propionamide
  • C999-0314
  • NCGC00114661-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0115 0.0168 0.0182
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.012 0.019 0.1941
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0147 0.0326 0.0317
Trichomonas vaginalis CMGC family protein kinase 0.0178 0.0472 0.2397
Schistosoma mansoni adapter molecule crk 0.0101 0.0101 0.0184
Brugia malayi SH2 domain containing protein 0.012 0.0192 0.0209
Brugia malayi Matrixin family protein 0.0145 0.0314 0.0341
Entamoeba histolytica protein kinase, putative 0.0183 0.05 0.2504
Echinococcus granulosus nervana 2 0.0201 0.0586 0.0578
Trichomonas vaginalis AGC family protein kinase 0.0255 0.0846 0.4296
Loa Loa (eye worm) SRC-1 0.0261 0.0877 0.0952
Brugia malayi Protein kinase domain containing protein 0.0238 0.0764 0.083
Echinococcus granulosus tyrosine protein kinase HCK 0.016 0.0387 0.0378
Echinococcus multilocularis cyclin dependent kinase 1 0.0218 0.0666 0.0798
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0528 0.2167 0.216
Trichomonas vaginalis CMGC family protein kinase 0.0183 0.05 0.2539
Entamoeba histolytica protein kinase, putative 0.0147 0.0326 0.1614
Trypanosoma brucei cdc2-related kinase 1 0.0218 0.0666 0.3351
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0275 0.0943 0.4764
Schistosoma mansoni tyrosine kinase 0.0261 0.0877 0.1594
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0235 0.075 0.7937
Trichomonas vaginalis AGC family protein kinase 0.0238 0.0764 0.388
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0238 0.0764 0.0917
Leishmania major protein kinase, putative 0.0097 0.0082 0.0371
Schistosoma mansoni protein kinase 0.0115 0.0168 0.0305
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0275 0.0943 0.4764
Schistosoma mansoni kinase 0.0397 0.1533 0.2787
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0143 0.0302 0.1692
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0145 0.0311 0.1542
Echinococcus granulosus serine:threonine protein kinase 3 0.0513 0.2098 0.2091
Echinococcus multilocularis raf serine:threonine protein kinase 0.0137 0.0273 0.0321
Brugia malayi Tyrosine-protein kinase abl-1 0.0256 0.0853 0.0926
Toxoplasma gondii AGC kinase 0.012 0.019 0.1047
Leishmania major casein kinase, putative 0.0115 0.0168 0.0809
Schistosoma mansoni protein kinase 0.0097 0.0082 0.0149
Schistosoma mansoni serine/threonine protein kinase 0.0314 0.1132 0.2058
Trypanosoma brucei casein kinase I, isoform 2 0.0115 0.0168 0.0809
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.019 0.022
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0225 0.0701 0.3563
Schistosoma mansoni serine/threonine protein kinase 0.0175 0.046 0.0836
Echinococcus multilocularis mitogen activated protein kinase 11 0.0304 0.1084 0.1307
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.0745 0.1355
Loa Loa (eye worm) hypothetical protein 0.0101 0.0101 0.011
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0147 0.0326 0.0384
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Schistosoma mansoni ephrin receptor 0.0201 0.0583 0.1059
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Brugia malayi phosphoinositide-dependent protein kinase I 0.0138 0.0278 0.0302
Schistosoma mansoni hypothetical protein 0.0096 0.0074 0.0135
Loa Loa (eye worm) TK/EPH protein kinase 0.0238 0.0765 0.0831
Loa Loa (eye worm) hypothetical protein 0.0297 0.1051 0.1142
Schistosoma mansoni serine/threonine protein kinase 0.0376 0.1433 0.2605
Loa Loa (eye worm) hypothetical protein 0.0163 0.0398 0.0433
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0599 0.2511 0.2504
Toxoplasma gondii AGC kinase 0.0439 0.1739 1
Plasmodium vivax glycogen synthase kinase 3, putative 0.0183 0.05 0.5256
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Onchocerca volvulus 0.0175 0.0458 0.0886
Brugia malayi casein kinase I 0.0115 0.0168 0.0182
Brugia malayi Sex muscle abnormal protein 5 0.0101 0.0101 0.011
Trypanosoma brucei rac serine-threonine kinase, putative 0.0451 0.1796 0.9119
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.0764 0.1389
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.013 0.024 0.0281
Echinococcus granulosus casein kinase I delta 0.0115 0.0168 0.0159
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0147 0.0326 0.0384
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0168 0.0306
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0314 0.1132 0.123
Onchocerca volvulus 0.012 0.0192 0.0367
Echinococcus multilocularis casein kinase I alpha 0.0115 0.0168 0.0193
Loa Loa (eye worm) hypothetical protein 0.0177 0.0467 0.0508
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0376 0.1433 0.2787
Leishmania major protein kinase A catalytic subunit isoform 2 0.012 0.019 0.0924
Echinococcus granulosus serine:threonine protein kinase 0.0161 0.039 0.0381
Trypanosoma cruzi cdc2-related kinase 1 0.0218 0.0666 0.3382
Brugia malayi Hr1 repeat family protein 0.0238 0.0764 0.083
Loa Loa (eye worm) hypothetical protein 0.012 0.0192 0.0209
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.013 0.024 0.0231
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0225 0.0701 0.3533
Brugia malayi MAP kinase sur-1 0.0143 0.0302 0.0328
Trichomonas vaginalis CMGC family protein kinase 0.0178 0.0472 0.2397
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.012 0.019 0.0924
Trichomonas vaginalis AGC family protein kinase 0.0451 0.1796 0.9123
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0302 0.1533
Loa Loa (eye worm) hypothetical protein 0.0371 0.1407 0.1528
Trypanosoma brucei polo-like protein kinase 0.0487 0.1969 1
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0114 0.0163 0.0177
Echinococcus granulosus cyclin dependent kinase 1 0.0218 0.0666 0.0657
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0282 0.0977 0.1061
Entamoeba histolytica protein kinase, putative 0.0225 0.0701 0.3533
Echinococcus granulosus aurora kinase A 0.0275 0.0943 0.0934
Echinococcus granulosus roundabout 2 0.0242 0.0784 0.0776
Leishmania major protein kinase, putative 0.0275 0.0943 0.4764
Onchocerca volvulus 0.1041 0.4652 0.9063
Echinococcus multilocularis ephrin type A receptor 4 A 0.0201 0.0583 0.0697
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0487 0.1969 0.2138
Loa Loa (eye worm) hypothetical protein 0.0114 0.0162 0.0176
Brugia malayi cell division control protein 2 homolog 0.0218 0.0666 0.0723
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0101 0.0101 0.0184
Echinococcus multilocularis Immunoglobulin 0.0162 0.0396 0.047
Echinococcus granulosus protein kinase shaggy 0.0183 0.05 0.0491
Trichomonas vaginalis STE family protein kinase 0.0255 0.0846 0.4296
Schistosoma mansoni hypothetical protein 0.0206 0.0608 0.1105
Brugia malayi Protein kinase c protein 2 0.0195 0.0555 0.0602
Echinococcus multilocularis cyclin dependent kinase 5 0.0218 0.0666 0.0798
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0183 0.05 0.2836
Trichomonas vaginalis CAMK family protein kinase 0.0487 0.1969 1
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0255 0.0846 0.4836
Brugia malayi Protein kinase domain containing protein 0.012 0.0192 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0487 0.1969 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0218 0.0666 0.3796
Trypanosoma cruzi Protein kinase B 0.0247 0.0807 0.41
Brugia malayi Tyrosine-protein kinase abl-1 0.0148 0.0329 0.0358
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0278 0.1414
Schistosoma mansoni tyrosine kinase 0.1216 0.5501 1
Echinococcus granulosus tyrosine protein kinase Fps85D 0.012 0.0192 0.0183
Toxoplasma gondii CMGC kinase, CK2 family 0.0178 0.0472 0.2674
Echinococcus multilocularis dual specificity 0.0225 0.0701 0.0841
Schistosoma mansoni serine/threonine protein kinase 0.0487 0.1969 0.3579
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0439 0.1739 0.1889
Entamoeba histolytica protein kinase, putative 0.0238 0.0764 0.3851
Echinococcus granulosus Protein kinase C brain isozyme 0.0399 0.1544 0.1536
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0418 0.1637 0.1778
Plasmodium falciparum glycogen synthase kinase 3 0.0183 0.05 0.5256
Leishmania major protein kinase A catalytic subunit isoform 1 0.012 0.019 0.0924
Brugia malayi RhoGAP domain containing protein 0.013 0.024 0.0261
Loa Loa (eye worm) TK/EGFR protein kinase 0.1216 0.5501 0.5974
Echinococcus multilocularis nervana 2 0.0201 0.0586 0.0701
Loa Loa (eye worm) hypothetical protein 0.0255 0.0846 0.0918
Echinococcus multilocularis myosin iiia 0.0145 0.0311 0.0367
Onchocerca volvulus Matrix metalloproteinase homolog 0.0322 0.117 0.2275
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0081 0.0004 0.002
Plasmodium falciparum protein kinase 5 0.0218 0.0666 0.7034
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Brugia malayi Protein kinase domain containing protein 0.0393 0.1516 0.1647
Mycobacterium ulcerans hydrolase 0.0177 0.0467 0.5
Brugia malayi Protein kinase domain containing protein 0.0376 0.1433 0.1557
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.045 0.1792 0.2167
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0261 0.0877 0.1054
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0302 0.1533
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1305 0.5934 0.6444
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Schistosoma mansoni protein kinase 0.0101 0.01 0.0183
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0261 0.0877 0.1054
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.0666 0.121
Echinococcus multilocularis protein kinase c epsilon type 0.0314 0.1132 0.1365
Trypanosoma cruzi casein kinase, putative 0.0115 0.0168 0.0852
Trichomonas vaginalis CAMK family protein kinase 0.0234 0.0744 0.3781
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0201 0.0586 0.0701
Schistosoma mansoni serine/threonine protein kinase 0.0289 0.101 0.1835
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0235 0.075 0.0742
Echinococcus multilocularis mitogen activated protein kinase 0.0143 0.0302 0.0356
Giardia lamblia Kinase, NEK 0.0255 0.0846 0.4269
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0599 0.2511 0.2727
Trichomonas vaginalis CAMK family protein kinase 0.0487 0.1969 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0115 0.0168 0.0159
Trypanosoma cruzi cdc2-related kinase 3 0.0218 0.0666 0.3382
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.012 0.019 0.0967
Plasmodium falciparum serine/threonine protein kinase, putative 0.0275 0.0943 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0218 0.0666 0.0798
Echinococcus granulosus epidermal growth factor receptor 0.077 0.3341 0.3335
Echinococcus granulosus RNA directed DNA polymerase 0.0085 0.0023 0.0013
Brugia malayi hypothetical protein 0.012 0.0192 0.0209
Echinococcus multilocularis calcium activated potassium channel 0.0129 0.0238 0.0278
Onchocerca volvulus 0.0297 0.1051 0.2042
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0275 0.0943 0.4764
Entamoeba histolytica protein kinase domain containing protein 0.0097 0.0082 0.0371
Giardia lamblia Kinase, CMGC MAPK 0.0143 0.0302 0.1493
Echinococcus granulosus mitogen activated protein kinase 0.0143 0.0302 0.0293
Schistosoma mansoni serine/threonine protein kinase 0.0418 0.1637 0.2975
Trichomonas vaginalis AGC family protein kinase 0.0275 0.0943 0.4788
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0162 0.0396 0.047
Brugia malayi Protein kinase domain containing protein 0.03 0.1066 0.1157
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.012 0.019 0.0967
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0082 0.0009 0.0047
Echinococcus multilocularis tyrosine protein kinase Blk 0.0217 0.0661 0.0792
Echinococcus granulosus epidermal growth factor receptor 0.1216 0.5501 0.5497
Brugia malayi Kinase associated domain 1 family protein 0.0096 0.0074 0.0081
Schistosoma mansoni protein kinase 0.0178 0.0472 0.0858
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0183 0.05 0.0543
Schistosoma mansoni tyrosine kinase 0.0131 0.0244 0.0443
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0289 0.101 0.1216
Trypanosoma brucei protein kinase, putative 0.0143 0.0302 0.1493
Schistosoma mansoni serine/threonine protein kinase 0.0529 0.2175 0.3954
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Schistosoma mansoni protein kinase 0.043 0.1696 0.3082
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0275 0.0943 0.1135
Entamoeba histolytica protein kinase, putative 0.0451 0.1796 0.9119
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0217 0.0661 0.0652
Trichomonas vaginalis CK1 family protein kinase 0.0115 0.0168 0.0852
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0099 0.0092 0.0083
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0143 0.0302 0.1493
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0217 0.0661 0.0792
Schistosoma mansoni protein kinase 0.0147 0.0326 0.0592
Schistosoma mansoni serine/threonine kinase 0.0129 0.0238 0.0433
Onchocerca volvulus 0.0248 0.0813 0.1578
Echinococcus granulosus ephrin type A receptor 4 A 0.0201 0.0583 0.0574
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0238 0.0433
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0802 0.3497 0.4239
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Trypanosoma cruzi aurora B kinase, putative 0.0275 0.0943 0.4788
Schistosoma mansoni ste20-related kinase 0.0403 0.1562 0.2839
Echinococcus granulosus tyrosine protein kinase ABL1 0.036 0.1355 0.1347
Schistosoma mansoni tyrosine kinase 0.077 0.3341 0.6073
Trichomonas vaginalis CAMK family protein kinase 0.0487 0.1969 1
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0082 0.0009 0.001
Trichomonas vaginalis CMGC family protein kinase 0.0178 0.0472 0.2397
Echinococcus granulosus rho-associated protein kinase 1 0.066 0.2807 0.28
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Loa Loa (eye worm) matrix metalloproteinase 0.0145 0.0314 0.0341
Loa Loa (eye worm) hypothetical protein 0.012 0.019 0.0207
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0488 0.1976 0.239
Loa Loa (eye worm) hypothetical protein 0.0237 0.0759 0.0825
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0487 0.1969 0.1961
Echinococcus granulosus tyrosine protein kinase Fyn 0.0261 0.0877 0.0868
Schistosoma mansoni protein kinase 0.043 0.1696 0.3082
Onchocerca volvulus 0.0206 0.0608 0.1178
Brugia malayi Protein kinase domain containing protein 0.0225 0.0701 0.0762
Echinococcus multilocularis rac serine:threonine kinase 0.0247 0.0807 0.097
Loa Loa (eye worm) TK protein kinase 0.0217 0.0661 0.0718
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0393 0.1516 0.1508
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0304 0.1084 0.5486
Echinococcus multilocularis nervana 2 0.0201 0.0586 0.0701
Echinococcus multilocularis roundabout 2 0.0242 0.0784 0.0942
Brugia malayi Stress-activated protein kinase jnk-1 0.0529 0.2175 0.2362
Echinococcus granulosus N chimaerin 0.013 0.024 0.0231
Onchocerca volvulus Matrilysin homolog 0.0145 0.0314 0.0605
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0393 0.1516 0.1647
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.012 0.019 0.0924
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0399 0.1544 0.1865
Leishmania major casein kinase II, putative 0.0178 0.0472 0.2361
Onchocerca volvulus 0.012 0.0192 0.0367
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0218 0.0666 0.0723
Echinococcus granulosus tyrosine protein kinase Fyn 0.0261 0.0877 0.0868
Toxoplasma gondii casein kinase I 0.0115 0.0168 0.0916
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0666 0.3382
Echinococcus granulosus tyrosine protein kinase shark 0.012 0.0192 0.0183
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0261 0.0877 0.1054
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0225 0.0701 0.0762
Echinococcus multilocularis insulin receptor 0.0797 0.3472 0.4208
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.012 0.019 0.0207
Schistosoma mansoni tyrosine kinase 0.0165 0.0408 0.0742
Brugia malayi p70 ribosomal S6 kinase beta 0.0439 0.1739 0.1889
Echinococcus multilocularis mitogen activated protein kinase 14 0.0304 0.1084 0.1307
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0115 0.0168 0.0193
Echinococcus granulosus NCK adaptor protein 0.0101 0.0101 0.0092
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.012 0.019 0.0967
Schistosoma mansoni serine/threonine protein kinase 0.012 0.019 0.0346
Echinococcus multilocularis tyrosine protein kinase shark 0.012 0.0192 0.0222
Leishmania major protein kinase A catalytic subunit 0.012 0.019 0.0924
Trypanosoma cruzi casein kinase, putative 0.0115 0.0168 0.0852
Loa Loa (eye worm) hypothetical protein 0.0082 0.0009 0.001
Brugia malayi Matrixin family protein 0.0351 0.1311 0.1424
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0418 0.1637 0.1629
Entamoeba histolytica p21-activated kinase 0.0159 0.0383 0.1905
Brugia malayi Matrixin family protein 0.0145 0.0314 0.0341
Echinococcus granulosus cyclin dependent kinase 0.0218 0.0666 0.0657
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0143 0.0302 0.1493
Schistosoma mansoni vav2 0.0142 0.0297 0.054
Schistosoma mansoni growth factor receptor-bound protein 0.0101 0.0101 0.0184
Trypanosoma cruzi cdc2-related kinase 3 0.0218 0.0666 0.3382
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0178 0.0472 0.4956
Brugia malayi P38 map kinase family protein 2 0.0304 0.1084 0.1177
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0599 0.2511 0.3041
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0487 0.1969 0.2382
Echinococcus granulosus dual specificity testis-specific protein kinase 0.043 0.1696 0.1688
Trichomonas vaginalis AGC family protein kinase 0.0451 0.1796 0.9123
Schistosoma mansoni serine/threonine protein kinase 0.0143 0.0302 0.0549
Echinococcus multilocularis dual specificity testis specific protein kinase 0.043 0.1696 0.205
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0143 0.0302 0.1493
Onchocerca volvulus Serine\/threonine kinase homolog 0.0487 0.1969 0.3831
Echinococcus granulosus serine/threonine protein kinase 0.0247 0.0807 0.0799
Brugia malayi Immunoglobulin I-set domain containing protein 0.0524 0.2149 0.2334
Brugia malayi Casein kinase II, alpha chain 0.0178 0.0472 0.0512
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0261 0.0877 0.0868
Brugia malayi Protein kinase domain containing protein 0.0218 0.0666 0.0723
Brugia malayi serine/threonine kinase 12 0.0275 0.0943 0.1024
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0201 0.0586 0.0578
Entamoeba histolytica serine/threonine protein kinase, putative 0.0487 0.1969 1
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0144 0.0309 0.03
Trichomonas vaginalis AGC family protein kinase 0.012 0.019 0.0967
Giardia lamblia Kinase, CMGC GSK 0.0183 0.05 0.2504
Entamoeba histolytica protein kinase , putative 0.0275 0.0943 0.4764
Schistosoma mansoni serine/threonine protein kinase 0.0115 0.0168 0.0305
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0097 0.0082 0.0421
Echinococcus multilocularis neuroglian 0.0198 0.057 0.0681
Echinococcus multilocularis cyclin dependent kinase 0.0218 0.0666 0.0798
Entamoeba histolytica protein kinase 2, putative 0.0235 0.075 0.3781
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0529 0.2175 0.2362
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Loa Loa (eye worm) hypothetical protein 0.0145 0.0314 0.0341
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.0745 0.1355
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0393 0.1516 0.1831
Echinococcus multilocularis mitogen activated protein kinase 11 0.0304 0.1084 0.1307
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0177 0.0467 0.5
Echinococcus granulosus c src tyrosine kinase 0.0165 0.0408 0.0399
Loa Loa (eye worm) hypothetical protein 0.0191 0.0538 0.0584
Echinococcus granulosus protein kinase C gamma type 0.0326 0.1189 0.118
Plasmodium vivax casein kinase 1, putative 0.0115 0.0168 0.1698
Toxoplasma gondii AGC kinase 0.012 0.019 0.1047
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0278 0.1414
Schistosoma mansoni atypical protein kinase C 0.0502 0.2043 0.3713
Giardia lamblia Kinase, AGC PKA 0.012 0.019 0.0924
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0153 0.0354 0.0419
Onchocerca volvulus 0.0115 0.0168 0.0319
Echinococcus multilocularis casein kinase I alpha 0.0115 0.0168 0.0193
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0082 0.0009 0.0047
Entamoeba histolytica protein kinase, putative 0.0115 0.0168 0.0811
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0145 0.0311 0.1582
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0121 0.02 0.0217
Onchocerca volvulus 0.066 0.2807 0.5465
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0289 0.101 0.1096
Trichomonas vaginalis STE family protein kinase 0.0101 0.01 0.051
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0129 0.0238 0.0258
Brugia malayi Temporarily assigned gene name protein 59 0.0276 0.095 0.1032
Echinococcus multilocularis epidermal growth factor receptor 0.1216 0.5501 0.6675
Brugia malayi Protein kinase domain containing protein 0.0238 0.0764 0.083
Echinococcus multilocularis tyrosine protein kinase HCK 0.016 0.0387 0.0459
Entamoeba histolytica PH domain containing protein kinase, putative 0.0131 0.0247 0.1216
Loa Loa (eye worm) matrixin family protein 0.0351 0.1311 0.1424
Loa Loa (eye worm) TK/ABL protein kinase 0.036 0.1355 0.1472
Echinococcus multilocularis mitogen activated protein kinase 14 0.0304 0.1084 0.1307
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0304 0.1084 0.5507
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0143 0.0302 0.1533
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0488 0.1976 0.239
Echinococcus granulosus serine threonine protein kinase nrc 0.0235 0.075 0.0742
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.077 0.3341 0.3335
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0225 0.0701 0.3563
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.019 0.022
Brugia malayi putative serine/threonine kinase SADA gamma 0.0082 0.0009 0.001
Brugia malayi Matrixin family protein 0.0145 0.0314 0.0341
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0143 0.0302 0.1533
Brugia malayi Variant SH3 domain containing protein 0.0101 0.0101 0.011
Brugia malayi Matrixin family protein 0.0145 0.0314 0.0341
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Echinococcus granulosus Glutaredoxin protein 5 0.0201 0.0586 0.0578
Echinococcus granulosus casein kinase I delta 0.0115 0.0168 0.0159
Loa Loa (eye worm) hypothetical protein 0.0161 0.039 0.0423
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0218 0.0666 0.0657
Brugia malayi protein kinase C3,putative 0.0285 0.099 0.1076
Echinococcus multilocularis tyrosine protein kinase Abl 0.0256 0.0853 0.1025
Giardia lamblia Kinase, AGC PKA 0.0235 0.075 0.3781
Loa Loa (eye worm) hypothetical protein 0.0167 0.0421 0.0457
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0235 0.075 0.09
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0376 0.1433 0.1425
Trichomonas vaginalis CMGC family protein kinase 0.0178 0.0472 0.2397
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0853 0.155
Brugia malayi ephrin receptor 1 precursor 0.0128 0.0231 0.0251
Entamoeba histolytica protein kinase, putative 0.009 0.0049 0.0202
Loa Loa (eye worm) hypothetical protein 0.0096 0.0074 0.0081
Entamoeba histolytica casein kinase 1, putative 0.0115 0.0168 0.0809
Loa Loa (eye worm) hypothetical protein 0.0085 0.0023 0.0025
Echinococcus multilocularis serine threonine protein kinase 0.0326 0.1189 0.1433
Onchocerca volvulus Matrilysin homolog 0.0322 0.117 0.2275
Trichomonas vaginalis CMGC family protein kinase 0.0183 0.05 0.2539
Schistosoma mansoni tyrosine kinase 0.0488 0.1976 0.3591
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0218 0.0666 0.3351
Echinococcus granulosus fibroblast growth factor receptor 4 0.0488 0.1976 0.1968
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0261 0.0877 0.1054
Trichomonas vaginalis AGC family protein kinase 0.0275 0.0943 0.4788
Brugia malayi hypothetical protein 0.0167 0.0421 0.0457
Echinococcus granulosus tyrosine protein kinase Lyn 0.0295 0.1041 0.1032
Giardia lamblia Kinase, AGC AKT 0.0214 0.0648 0.3259
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0147 0.0326 0.0384
Trypanosoma brucei aurora B kinase 0.0275 0.0943 0.4764
Loa Loa (eye worm) AUR protein kinase 0.0275 0.0943 0.1024
Trypanosoma cruzi casein kinase, putative 0.0115 0.0168 0.0852
Echinococcus granulosus activin receptor type 0.0097 0.0082 0.0073
Trichomonas vaginalis AGC family protein kinase 0.0238 0.0764 0.388
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Echinococcus multilocularis serine:threonine protein kinase 0.0161 0.039 0.0462
Trichomonas vaginalis STE family protein kinase 0.0147 0.0326 0.1653
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0275 0.0943 0.0934
Brugia malayi SRC-1 0.0261 0.0877 0.0952
Schistosoma mansoni serine/threonine protein kinase 0.066 0.2807 0.5103
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Onchocerca volvulus 0.012 0.0192 0.0367
Loa Loa (eye worm) AGC/NDR protein kinase 0.0238 0.0764 0.083
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1981 0.9208 1
Brugia malayi Protein kinase domain containing protein 0.012 0.0192 0.0209
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Loa Loa (eye worm) hypothetical protein 0.0145 0.0314 0.0341
Trypanosoma cruzi polo-like protein kinase, putative 0.0487 0.1969 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0115 0.0168 0.0193
Trypanosoma cruzi polo-like protein kinase, putative 0.0487 0.1969 1
Schistosoma mansoni serine/threonine protein kinase 0.0399 0.1544 0.2806
Echinococcus granulosus tyrosine protein kinase Src64B 0.0261 0.0877 0.0868
Loa Loa (eye worm) hypothetical protein 0.0167 0.0421 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.039 0.1979
Brugia malayi Hemopexin family protein 0.0206 0.0608 0.066
Onchocerca volvulus 0.026 0.087 0.169
Echinococcus multilocularis activin receptor type 0.0097 0.0082 0.0088
Schistosoma mansoni tyrosine kinase 0.0797 0.3472 0.6311
Plasmodium vivax unspecified product 0.0178 0.0472 0.4956
Brugia malayi Protein kinase domain containing protein 0.0362 0.1365 0.1482
Entamoeba histolytica protein kinase domain containing protein 0.0275 0.0943 0.4764
Onchocerca volvulus 0.012 0.0192 0.0367
Trichomonas vaginalis CMGC family protein kinase 0.0178 0.0472 0.2397
Echinococcus granulosus neuroglian 0.0198 0.057 0.0561
Schistosoma mansoni tyrosine kinase 0.0138 0.0282 0.0512
Echinococcus multilocularis serine:threonine protein kinase 0.0161 0.039 0.0462
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.0666 0.121
Loa Loa (eye worm) TK/INSR protein kinase 0.0797 0.3472 0.377
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0086 0.0027 0.0017
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0289 0.101 0.1001
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0162 0.0396 0.072
Trichomonas vaginalis AGC family protein kinase 0.0451 0.1796 0.9123
Brugia malayi serine/threonine-protein kinase plk-2 0.0487 0.1969 0.2138
Entamoeba histolytica protein kinase, putative 0.0115 0.0168 0.0811
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0261 0.0877 0.1054
Loa Loa (eye worm) hypothetical protein 0.0248 0.0813 0.0883
Echinococcus multilocularis N chimaerin 0.013 0.024 0.0281
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0666 0.3382
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.012 0.019 0.0924
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0115 0.0168 0.0182
Loa Loa (eye worm) hypothetical protein 0.0191 0.0538 0.0584
Brugia malayi STE20-like kinase MST 0.0513 0.2098 0.2279
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0183 0.05 0.0543
Onchocerca volvulus 0.0183 0.05 0.0967
Echinococcus multilocularis RNA directed DNA polymerase 0.0085 0.0023 0.0016
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0183 0.05 0.0491
Schistosoma mansoni tyrosine kinase 0.0165 0.0408 0.0742
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.012 0.019 0.1941
Giardia lamblia Kinase, CMGC CK2 0.0178 0.0472 0.2361
Onchocerca volvulus 0.0626 0.2643 0.5146
Schistosoma mansoni hypothetical protein 0.0096 0.0074 0.0135
Loa Loa (eye worm) TK/FER protein kinase 0.012 0.0192 0.0209
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0304 0.1084 0.5486
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0282 0.0977 0.1061
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.0701 0.1275
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.012 0.019 0.0181
Plasmodium falciparum casein kinase 1 0.0115 0.0168 0.1698
Brugia malayi serine/threonine protein kinase 6 0.0275 0.0943 0.1024
Loa Loa (eye worm) hypothetical protein 0.0297 0.1051 0.1142
Echinococcus granulosus mitogen activated protein kinase 3 0.0143 0.0302 0.0293
Schistosoma mansoni serine/threonine-protein kinase 0.0247 0.0807 0.1467
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0513 0.2098 0.2279
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0235 0.075 0.381
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.046 0.1841 0.2
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0247 0.0807 0.41
Schistosoma mansoni tyrosine kinase 0.0707 0.3034 0.5515
Echinococcus multilocularis casein kinase I alpha 0.0115 0.0168 0.0193
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0255 0.0846 0.8961
Schistosoma mansoni serine/threonine protein kinase 0.0275 0.0943 0.1714
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0138 0.0278 0.0327
Trichomonas vaginalis CAMK family protein kinase 0.0129 0.0238 0.1209
Entamoeba histolytica protein kinase, putative 0.0225 0.0701 0.3533
Giardia lamblia Kinase, CMGC CDK 0.0218 0.0666 0.3351
Brugia malayi serine/threonine-protein kinase 6 0.0275 0.0943 0.1024
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0304 0.1084 0.1177
Loa Loa (eye worm) hypothetical protein 0.0237 0.0759 0.0824
Schistosoma mansoni nck2/grb4 0.0101 0.0101 0.0184
Echinococcus multilocularis c src tyrosine kinase 0.0165 0.0408 0.0485
Schistosoma mansoni vesicular amine transporter 0.0162 0.0396 0.072
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0138 0.0278 0.0302
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0487 0.1969 1
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Trypanosoma cruzi casein kinase, putative 0.0115 0.0168 0.0852
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0256 0.0853 0.1025
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0138 0.0278 0.0302
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0302 0.1533
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0214 0.0648 0.0704
Loa Loa (eye worm) matrixin family protein 0.0322 0.117 0.1271
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0261 0.0877 0.1054
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0115 0.0168 0.0182
Echinococcus granulosus tyrosine kinase 0.012 0.0192 0.0183
Loa Loa (eye worm) hypothetical protein 0.0167 0.0421 0.0457
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0261 0.0877 0.1054
Brugia malayi Fibronectin type III domain containing protein 0.0167 0.0421 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Echinococcus multilocularis rho associated protein kinase 0.066 0.2807 0.34
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0618 0.2606 0.283
Echinococcus multilocularis 0.0355 0.1331 0.1607
Loa Loa (eye worm) hypothetical protein 0.0155 0.0363 0.0394
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0162 0.0396 0.072
Entamoeba histolytica PH domain containing protein kinase, putative 0.0247 0.0807 0.4072
Entamoeba histolytica protein kinase, putative 0.016 0.0387 0.1927
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0183 0.05 0.2504
Echinococcus granulosus casein kinase i 0.0115 0.0168 0.0159
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0226 0.0705 0.355
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Brugia malayi Protein kinase domain 0.0147 0.0326 0.0354
Onchocerca volvulus 0.0145 0.0314 0.0605
Loa Loa (eye worm) hypothetical protein 0.0184 0.0502 0.0545
Brugia malayi Protein kinase domain containing protein 0.0797 0.3472 0.377
Trichomonas vaginalis CAMK family protein kinase 0.0487 0.1969 1
Schistosoma mansoni nephrin 0.0203 0.0595 0.1081
Trypanosoma cruzi cdc2-related kinase 1 0.0218 0.0666 0.3382
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0256 0.0853 0.1025
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.0162 0.0821
Echinococcus granulosus mitogen activated protein kinase 11 0.0304 0.1084 0.1076
Echinococcus granulosus tyrosine protein kinase Blk 0.0217 0.0661 0.0652
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0145 0.0311 0.1542
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0234 0.0745 0.0895
Trichomonas vaginalis AGC family protein kinase 0.0451 0.1796 0.9123
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0177 0.0467 0.0508
Entamoeba histolytica casein kinase, putative 0.0115 0.0168 0.0809
Echinococcus granulosus dual specificity 0.0225 0.0701 0.0693
Echinococcus granulosus protein kinase c iota type 0.0489 0.1979 0.1972
Schistosoma mansoni serine/threonine protein kinase 0.0399 0.1544 0.2806
Loa Loa (eye worm) AUR protein kinase 0.0275 0.0943 0.1024
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.019 0.022
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0256 0.0853 0.0844
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0261 0.0877 0.1054
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0528 0.2167 0.2623
Schistosoma mansoni tyrosine kinase 0.0797 0.3472 0.6311
Echinococcus multilocularis hypothetical protein 0.0096 0.0074 0.0079
Trichomonas vaginalis AGC family protein kinase 0.0451 0.1796 0.9123
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0165 0.0408 0.0742
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0235 0.075 0.7937
Echinococcus multilocularis serine:threonine protein kinase 3 0.0513 0.2098 0.2539
Entamoeba histolytica protein kinase, putative 0.0439 0.1739 0.8828
Schistosoma mansoni tyrosine kinase 0.0304 0.1081 0.1965
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0115 0.0168 0.0159
Entamoeba histolytica cell division protein kinase 2, putative 0.0218 0.0666 0.3351
Trichomonas vaginalis AGC family protein kinase 0.0275 0.0943 0.4788
Entamoeba histolytica protein kinase, putative 0.0113 0.0158 0.0757
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.013 0.024 0.0437
Entamoeba histolytica casein kinase, putative 0.0178 0.0472 0.2361
Entamoeba histolytica cell division protein kinase 2, putative 0.0218 0.0666 0.3351
Echinococcus granulosus twitchin 0.0232 0.0733 0.0725
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0238 0.0764 0.0755
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0488 0.1976 0.1968
Schistosoma mansoni tyrosine kinase 0.077 0.3341 0.6073
Entamoeba histolytica protein kinase domain containing protein 0.0225 0.0701 0.3533
Giardia lamblia Kinase, NEK 0.0255 0.0846 0.4269
Giardia lamblia Kinase, PLK 0.0487 0.1969 1
Brugia malayi Variant SH3 domain containing protein 0.0101 0.0101 0.011
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0238 0.0764 0.0917
Schistosoma mansoni protein kinase C mu 0.0282 0.0977 0.1776
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0261 0.0877 0.1054
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0204 0.06 0.3048
Trichomonas vaginalis AGC family protein kinase 0.0451 0.1796 0.9123
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0238 0.0764 0.083
Schistosoma mansoni serine/threonine-protein kinase 0.0247 0.0807 0.1467
Echinococcus granulosus casein kinase I alpha 0.0115 0.0168 0.0159
Schistosoma mansoni tyrosine kinase 0.0707 0.3034 0.5515
Entamoeba histolytica protein kinase, putative 0.0451 0.1796 0.9119
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.012 0.019 0.0967
Echinococcus granulosus casein kinase I alpha 0.0115 0.0168 0.0159
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0256 0.0853 0.0844
Entamoeba histolytica protein kinase domain containing protein 0.0183 0.05 0.2504
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0278 0.0506
Echinococcus granulosus myotubularin protein 13 0.0085 0.0023 0.0014
Echinococcus multilocularis PAK box P21 Rho binding 0.0101 0.01 0.0111
Echinococcus multilocularis serine:threonine protein kinase N2 0.0238 0.0764 0.0917
Loa Loa (eye worm) TK protein kinase 0.016 0.0387 0.042
Trichomonas vaginalis CAMK family protein kinase 0.0487 0.1969 1
Giardia lamblia Kinase, CMGC CDK 0.0218 0.0666 0.3351
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Loa Loa (eye worm) hypothetical protein 0.0175 0.0458 0.0498
Schistosoma mansoni serine/threonine kinase 0.0238 0.0764 0.1389
Trichomonas vaginalis AGC family protein kinase 0.0451 0.1796 0.9123
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0144 0.0309 0.0364
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0218 0.0666 0.3351
Trypanosoma brucei protein kinase, putative 0.0183 0.05 0.2504
Loa Loa (eye worm) hypothetical protein 0.026 0.087 0.0945
Brugia malayi intracellular kinase 0.0183 0.05 0.0543
Entamoeba histolytica protein kinase, putative 0.0113 0.0158 0.0757
Entamoeba histolytica protein kinase, putative 0.0275 0.0943 0.4764
Giardia lamblia Kinase, CMGC GSK 0.0183 0.05 0.2504
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.013 0.024 0.0437
Echinococcus multilocularis NCK adaptor protein 0.0101 0.0101 0.0112
Brugia malayi SH2 domain containing protein 0.012 0.0192 0.0209
Entamoeba histolytica protein kinase, putative 0.0138 0.0278 0.1374
Echinococcus granulosus tyrosine protein kinase Srms 0.012 0.0192 0.0183
Brugia malayi Protein kinase domain containing protein 0.0129 0.0238 0.0258
Echinococcus multilocularis epidermal growth factor receptor 0.077 0.3341 0.4049
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0304 0.1084 0.5507
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0161 0.039 0.0423
Echinococcus granulosus cyclin dependent kinase 5 0.0218 0.0666 0.0657
Echinococcus multilocularis casein kinase I delta 0.0115 0.0168 0.0193
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0218 0.0666 0.0723
Brugia malayi protein kinase C II. 0.0314 0.1132 0.123
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0201 0.0586 0.0577
Echinococcus granulosus defective proboscis extension response 0.0162 0.0396 0.0387
Onchocerca volvulus 0.0137 0.0276 0.053
Loa Loa (eye worm) RhoGAP domain-containing protein 0.013 0.024 0.0261
Onchocerca volvulus 0.012 0.0192 0.0367
Entamoeba histolytica protein kinase domain containing protein 0.0183 0.05 0.2504
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0802 0.3497 0.3491
Loa Loa (eye worm) hypothetical protein 0.0162 0.0396 0.043
Brugia malayi Protein kinase domain containing protein 0.0451 0.1796 0.1951
Brugia malayi serine/threonine-protein kinase PAK 7 0.046 0.1841 0.2
Trichomonas vaginalis AGC family protein kinase 0.0275 0.0943 0.4788
Entamoeba histolytica hypothetical protein 0.0225 0.0701 0.3533
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0097 0.0082 0.0417
Schistosoma mansoni serine/threonine protein kinase 0.0599 0.2511 0.4564
Plasmodium falciparum casein kinase 2, alpha subunit 0.0178 0.0472 0.4956
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.012 0.0192 0.0222
Loa Loa (eye worm) hypothetical protein 0.0297 0.1051 0.1142
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0209 0.0622 0.0675
Trichomonas vaginalis AGC family protein kinase 0.025 0.0821 0.417
Schistosoma mansoni growth factor receptor-bound protein 0.0101 0.0101 0.0184
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0225 0.0701 0.3533
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0138 0.0278 0.0269
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0238 0.0433
Brugia malayi protein-tyrosine kinase 0.0217 0.0661 0.0718
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0145 0.0314 0.0571
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0101 0.0101 0.011
Brugia malayi Variant SH3 domain containing protein 0.013 0.024 0.0261
Trypanosoma cruzi casein kinase, putative 0.0115 0.0168 0.0852
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0143 0.0302 0.1533
Trichomonas vaginalis CAMK family protein kinase 0.0487 0.1969 1
Schistosoma mansoni cell adhesion molecule 0.0206 0.0611 0.1111
Leishmania major protein kinase, putative 0.0145 0.0311 0.1542
Echinococcus granulosus calcium activated potassium channel 0.0129 0.0238 0.0229
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0218 0.0666 0.0723
Schistosoma mansoni tyrosine kinase 0.0707 0.3034 0.5515
Schistosoma mansoni serine/threonine protein kinase 0.0129 0.0238 0.0433
Trypanosoma brucei cdc2-related kinase 3 0.0218 0.0666 0.3351
Echinococcus granulosus tyrosine kinase 0.0217 0.0661 0.0652
Loa Loa (eye worm) hypothetical protein 0.0085 0.0023 0.0025
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0183 0.05 0.0909
Entamoeba histolytica SH2-protein kinase domain containing protein 0.012 0.0192 0.0933
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0086 0.0027 0.0021
Echinococcus multilocularis tyrosine protein kinase ABL1 0.036 0.1355 0.1636
Echinococcus granulosus serine:threonine protein kinase 0.0161 0.039 0.0381
Trichomonas vaginalis CK1 family protein kinase 0.0115 0.0168 0.0852
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0261 0.0877 0.0868
Trichomonas vaginalis STE family protein kinase 0.0145 0.0311 0.1582
Schistosoma mansoni serine/threonine protein kinase 0.012 0.019 0.0346
Giardia lamblia Aurora kinase 0.0275 0.0943 0.4764
Loa Loa (eye worm) AGC/PKA protein kinase 0.012 0.019 0.0207
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0097 0.0082 0.0371
Loa Loa (eye worm) TK protein kinase 0.0524 0.2149 0.2334
Brugia malayi Protein kinase domain containing protein 0.012 0.0192 0.0209
Echinococcus granulosus tyrosine protein kinase Src42A 0.0261 0.0877 0.0868
Echinococcus multilocularis aurora kinase A 0.0275 0.0943 0.1135
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0097 0.0082 0.0417
Echinococcus multilocularis mitogen activated protein kinase 3 0.0143 0.0302 0.0356
Echinococcus multilocularis casein kinase ii subunit alpha 0.0178 0.0472 0.0562
Loa Loa (eye worm) hypothetical protein 0.0162 0.0396 0.043
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Loa Loa (eye worm) AGC/PKN protein kinase 0.0238 0.0764 0.083
Trichomonas vaginalis CAMK family protein kinase 0.0082 0.0009 0.0047
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.012 0.019 0.0181
Echinococcus granulosus tyrosine protein kinase Btk29A 0.045 0.1792 0.1785
Brugia malayi Immunoglobulin I-set domain containing protein 0.1305 0.5934 0.6444
Entamoeba histolytica protein kinase, putative 0.0101 0.01 0.0465
Trichomonas vaginalis CMGC family protein kinase 0.0218 0.0666 0.3382
Onchocerca volvulus 0.012 0.0192 0.0367
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0145 0.0311 0.1582
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0376 0.1433 0.1731
Loa Loa (eye worm) AGC/PKA protein kinase 0.012 0.019 0.0207
Echinococcus multilocularis serine:threonine protein kinase N2 0.0238 0.0764 0.0917
Loa Loa (eye worm) AGC/AKT protein kinase 0.0451 0.1796 0.1951
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0009 0.0017
Trichomonas vaginalis CMGC family protein kinase 0.0178 0.0472 0.2397
Entamoeba histolytica PH domain containing protein kinase, putative 0.0247 0.0807 0.4072
Brugia malayi Protein kinase domain containing protein 0.012 0.0192 0.0209
Giardia lamblia Kinase, CK1 Casein kinase 0.0115 0.0168 0.0809
Loa Loa (eye worm) hypothetical protein 0.0175 0.0458 0.0498
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0115 0.0168 0.0852
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0376 0.1433 0.1557
Brugia malayi casein kinase 1, delta 0.0115 0.0168 0.0182
Trichomonas vaginalis CMGC family protein kinase 0.0178 0.0472 0.2397
Trichomonas vaginalis AGC family protein kinase 0.0238 0.0764 0.388
Loa Loa (eye worm) TK/ROR protein kinase 0.0099 0.0092 0.01
Schistosoma mansoni tyrosine kinase 0.0406 0.1576 0.2865
Echinococcus multilocularis death associated protein kinase 1 0.1781 0.8237 1
Loa Loa (eye worm) hypothetical protein 0.0535 0.2204 0.2394
Echinococcus granulosus raf serine:threonine protein kinase 0.0137 0.0273 0.0264
Entamoeba histolytica protein kinase domain containing protein 0.0178 0.0472 0.2361
Brugia malayi Protein kinase domain containing protein 0.0161 0.039 0.0423
Echinococcus multilocularis protein kinase shaggy 0.0183 0.05 0.0596
Echinococcus granulosus mitogen activated protein kinase 14 0.0304 0.1084 0.1076
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0099 0.0092 0.01
Brugia malayi Furin-like cysteine rich region family protein 0.1216 0.5501 0.5974
Trypanosoma brucei Casein kinase II 0.0178 0.0472 0.2361
Echinococcus granulosus insulin receptor 0.0797 0.3472 0.3466
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0418 0.1637 0.1978
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0529 0.2175 0.2633
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0298 0.1054 0.1144
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0275 0.0943 1
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0289 0.101 0.1096
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0376 0.1433 0.1557
Loa Loa (eye worm) hypothetical protein 0.0158 0.0378 0.041
Echinococcus multilocularis tyrosine protein kinase Srms 0.0217 0.0661 0.0792
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0145 0.0311 0.1542
Schistosoma mansoni protein kinase 0.0275 0.0943 0.1714
Echinococcus multilocularis protein kinase c iota type 0.0489 0.1979 0.2395
Entamoeba histolytica PH domain containing protein kinase, putative 0.0131 0.0247 0.1216
Loa Loa (eye worm) hypothetical protein 0.0145 0.0314 0.0341
Schistosoma mansoni tyrosine kinase 0.012 0.0192 0.0349
Schistosoma mansoni tyrosine kinase 0.0261 0.0877 0.1594
Echinococcus multilocularis tyrosine kinase 0.012 0.0192 0.0222
Brugia malayi C1-like domain containing protein 0.0282 0.0977 0.1061
Echinococcus granulosus c-Jun N-terminal kinases 0.0529 0.2175 0.2168
Schistosoma mansoni serine/threonine protein kinase 0.0256 0.0853 0.155
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0143 0.0302 0.1533
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0183 0.05 0.2539
Trichomonas vaginalis CAMK family protein kinase 0.0234 0.0744 0.3781
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0178 0.0472 0.0512
Plasmodium falciparum NIMA related kinase 1 0.0255 0.0846 0.8961
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0238 0.0764 0.0755
Echinococcus multilocularis myotubularin protein 13 0.0085 0.0023 0.0017
Onchocerca volvulus Tyrosine kinase homolog 0.114 0.5133 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0167 0.0421 0.0457
Echinococcus granulosus serine:threonine protein kinase N2 0.0238 0.0764 0.0755
Loa Loa (eye worm) hypothetical protein 0.0237 0.0759 0.0825
Brugia malayi Protein kinase domain containing protein 0.1981 0.9208 1
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.0764 0.1389
Echinococcus granulosus growth factor receptor bound protein 2 0.0101 0.0101 0.0092
Echinococcus multilocularis Immunoglobulin 0.0162 0.0396 0.047
Trypanosoma cruzi casein kinase II, putative 0.0178 0.0472 0.2397
Giardia lamblia Kinase, STE STE20 0.0147 0.0326 0.1614
Entamoeba histolytica protein kinase, putative 0.0275 0.0943 0.4764
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0376 0.1433 0.1557
Onchocerca volvulus 0.0083 0.0012 0.0016
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0143 0.0302 0.0328
Echinococcus granulosus tyrosine protein kinase Fyn 0.0261 0.0877 0.0868
Echinococcus granulosus nervana 2 0.0201 0.0586 0.0578
Trypanosoma brucei protein kinase, putative 0.0097 0.0082 0.0371
Echinococcus granulosus protein kinase c epsilon type 0.0314 0.1132 0.1124
Giardia lamblia Kinase, STE STE20 0.0145 0.0311 0.1542
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.012 0.019 0.1047
Echinococcus multilocularis casein kinase I delta 0.0115 0.0168 0.0193
Echinococcus multilocularis growth factor receptor bound protein 2 0.0101 0.0101 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0137 0.0273 0.0497
Brugia malayi Protein kinase domain containing protein 0.012 0.0192 0.0209
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0101 0.0101 0.011
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0147 0.0326 0.0317
Plasmodium vivax protein kinase Crk2 0.0218 0.0666 0.7034
Trichomonas vaginalis CK1 family protein kinase 0.0115 0.0168 0.0852
Echinococcus multilocularis casein kinase i 0.0115 0.0168 0.0193
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0147 0.0326 0.0317
Echinococcus granulosus casein kinase ii subunit alpha 0.0178 0.0472 0.0463
Trichomonas vaginalis AGC family protein kinase 0.0138 0.0278 0.1414
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0009 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0393 0.1516 0.2756
Loa Loa (eye worm) hypothetical protein 0.0201 0.0586 0.0636
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0183 0.05 0.0596
Trichomonas vaginalis STE family protein kinase 0.0147 0.0326 0.1653
Trichomonas vaginalis CMGC family protein kinase 0.0143 0.0302 0.1533
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.012 0.019 0.0181
Brugia malayi Protein kinase domain containing protein 0.0138 0.0278 0.0302
Plasmodium falciparum protein kinase, putative 0.0097 0.0082 0.078
Trichomonas vaginalis STE family protein kinase 0.0147 0.0326 0.1653
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0234 0.0745 0.0737
Mycobacterium leprae PROBABLE HYDROLASE 0.0177 0.0467 0.5
Brugia malayi map kinase activated protein kinase protein 2 0.0599 0.2511 0.2727
Schistosoma mansoni serine/threonine protein kinase 0.012 0.019 0.0346
Echinococcus granulosus tyrosine protein kinase Src42A 0.0153 0.0354 0.0345
Loa Loa (eye worm) AUR protein kinase 0.0275 0.0943 0.1024
Trichomonas vaginalis STE family protein kinase 0.0147 0.0326 0.1653
Echinococcus multilocularis Glutaredoxin protein 5 0.0201 0.0586 0.0701
Echinococcus multilocularis serine:threonine protein kinase 38 0.0238 0.0764 0.0917
Echinococcus granulosus NDR protein kinase 0.0238 0.0764 0.0755
Echinococcus granulosus Immunoglobulin 0.0162 0.0396 0.0387
Echinococcus granulosus casein kinase I alpha 0.0115 0.0168 0.0159
Toxoplasma gondii aurora kinase 0.0275 0.0943 0.5396
Brugia malayi Pleckstrin Homology Domain 0.0085 0.0023 0.0025
Giardia lamblia Kinase, NEK 0.0255 0.0846 0.4269
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0085 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.0137 0.0276 0.0299
Schistosoma mansoni protein kinase 0.0147 0.0326 0.0592
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0009 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.0764 0.1389
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.012 0.019 0.022
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0009 0.0017
Entamoeba histolytica SH2-protein kinase domain containing protein 0.009 0.0049 0.0202

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Relaxin Receptor RXFP1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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