TDR Targets

Basic information

Technical information

TDR Targets ID: 1388101
Name: 1-(2,3-dihydro-1,4-benzodioxin-7-ylsulfonyl)p iperazine
MW: 284.331 | Formula: C12H16N2O4S
H donors: 1 H acceptors: 2 LogP: 0.13 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=S(=O)(c1ccc2c(c1)OCCO2)N1CCNCC1
InChi: 1S/C12H16N2O4S/c15-19(16,14-5-3-13-4-6-14)10-1-2-11-12(9-10)18-8-7-17-11/h1-2,9,13H,3-8H2
InChiKey: DHDNZVYHASSKPF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

T0514-7038
Oprea1_597343

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	PHD-finger family protein	0.0026	0.0164	0.0181
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.064	0.0632
Trypanosoma cruzi	target of rapamycin kinase 3	0.0037	0.035	0.0874
Entamoeba histolytica	glycogen phosphorylase, putative	0.0543	0.8611	1
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0009	0.0021
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0009	0.0021
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0089	0.0093
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0038	0.0353	0.0344
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0089	0.0222
Echinococcus multilocularis	concentrative Na+ nucleoside cotransporter	0.034	0.5296	0.5292
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0543	0.8611	1
Schistosoma mansoni	thymidylate kinase	0.0075	0.0969	0.1125
Echinococcus granulosus	concentrative Na nucleoside cotransporter	0.034	0.5296	0.5292
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.054	0.0532
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0047	0.0507	0.049
Leishmania major	cytidine deaminase-like protein	0.0053	0.0606	0.1514
Loa Loa (eye worm)	hypothetical protein	0.004	0.0394	0.0449
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0089	0.0837
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0394	0.0358
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.031	0.0259
Trypanosoma brucei	thymidylate kinase, putative	0.0075	0.0969	0.2419
Trypanosoma cruzi	cytidine deaminase-like protein, putative	0.0053	0.0606	0.1514
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0543	0.8611	1
Entamoeba histolytica	cytidine deaminase, putative	0.0053	0.0606	0.0607
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0987	0.1147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0254	0.0193
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0235	0.3575	0.3517
Onchocerca volvulus		0.0053	0.0606	0.0428
Echinococcus granulosus	solute carrier family 28	0.034	0.5296	0.5292
Trypanosoma cruzi	thymidylate kinase, putative	0.0075	0.0969	0.2419
Trichomonas vaginalis	thymidine kinase, putative	0.0261	0.4005	0.4596
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0245	0.3739	0.4336
Leishmania major	hypothetical protein, conserved	0.003	0.0221	0.0553
Echinococcus granulosus	thymidylate kinase	0.0075	0.0969	0.0961
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0089	0.0222
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0009	0.0021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0193	0.0122
Schistosoma mansoni	bromodomain containing protein	0.0066	0.082	0.0953
Loa Loa (eye worm)	hypothetical protein	0.0049	0.054	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0468	0.0534
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.003	0.0221	0.0553
Giardia lamblia	Glycogen phosphorylase	0.0543	0.8611	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0235	0.3575	0.409
Schistosoma mansoni	hypothetical protein	0.0022	0.0091	0.0106
Entamoeba histolytica	thymidine kinase, putative	0.0261	0.4005	0.4596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.031	0.0259
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0987	0.1138
Schistosoma mansoni	glycogen phosphorylase	0.0235	0.3575	0.4151
Brugia malayi	Bromodomain containing protein	0.004	0.0393	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0076
Mycobacterium ulcerans	cytidine deaminase	0.0053	0.0606	0.0522
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0235	0.3575	0.3569
Treponema pallidum	thymidylate kinase (tmk)	0.0075	0.0969	1
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.003	0.0221	0.0553
Echinococcus multilocularis	thymidine phosphorylase	0.0629	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0987	0.1138
Brugia malayi	RNA binding protein	0.0076	0.0987	0.1138
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.0629	1	1
Brugia malayi	hypothetical protein	0.0038	0.0354	0.0401
Echinococcus multilocularis	sodium:nucleoside cotransporter 2	0.0222	0.3363	0.3357
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0047	0.0507	0.0579
Schistosoma mansoni	ap endonuclease	0.0021	0.0089	0.0103
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.064	0.0734
Echinococcus granulosus	Glycosyl transferase family 35	0.0543	0.8611	0.861
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0987	0.098
Entamoeba histolytica	glycogen phosphorylase, putative	0.0543	0.8611	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.064	0.0743
Entamoeba histolytica	hypothetical protein	0.0038	0.0354	0.031
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0089	0.008
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0047	0.0507	0.0588
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0987	0.098
Trichomonas vaginalis	thymidylate kinase, putative	0.0075	0.0969	0.1033
Giardia lamblia	Cytidine deaminase	0.0053	0.0606	0.0607
Schistosoma mansoni	hypothetical protein	0.0051	0.0563	0.0654
Chlamydia trachomatis	glycogen phosphorylase	0.0543	0.8611	1
Brugia malayi	Pre-SET motif family protein	0.0031	0.0249	0.0279
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.031	0.0259
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.064	0.0743
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0047	0.0507	0.049
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.064	0.0632
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0354	0.0345
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0354	0.0411
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0047	0.0507	0.1265
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0249	0.0289
Leishmania major	thymidylate kinase-like protein	0.0075	0.0969	0.2419
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.054	0.0627
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.031	0.0259
Giardia lamblia	CDC8	0.0075	0.0969	0.1033
Echinococcus multilocularis	survival motor neuron protein 1	0.0248	0.3781	0.3776
Trichomonas vaginalis	thymidine kinase, putative	0.0261	0.4005	0.4596
Mycobacterium ulcerans	thymidine phosphorylase	0.0629	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0987	0.1147
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0089	0.008
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0075	0.0969	1
Plasmodium vivax	thymidylate kinase, putative	0.0075	0.0969	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0198	0.0127
Trypanosoma brucei	thymidine kinase	0.0261	0.4005	1
Trypanosoma brucei	thymidylate kinase, putative	0.0075	0.0969	0.2419
Mycobacterium tuberculosis	Probable anthranilate phosphoribosyltransferase TrpD	0.0177	0.2635	0.2629
Loa Loa (eye worm)	glycogen phosphorylase	0.0543	0.8611	1
Echinococcus multilocularis	geminin	0.0539	0.8533	0.8532
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.002	0.0058	0.0144
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0354	0.0345
Echinococcus granulosus	fetal alzheimer antigen falz	0.0024	0.0124	0.0115
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.035	0.0306
Trypanosoma cruzi	thymidylate kinase, putative	0.0075	0.0969	0.2419
Schistosoma mansoni	glycogen phosphorylase	0.0543	0.8611	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0047	0.0507	0.1265
Entamoeba histolytica	hypothetical protein	0.0038	0.0354	0.031
Giardia lamblia	Thymidine kinase	0.0261	0.4005	0.4596
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0076
Giardia lamblia	GTOR	0.0047	0.0507	0.049
Loa Loa (eye worm)	PHD-finger family protein	0.0022	0.0091	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0248	0.3781	0.4385
Trichomonas vaginalis	thymidine kinase, putative	0.0261	0.4005	0.4596
Onchocerca volvulus		0.0248	0.3788	0.4232
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.0759	0.0751
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0009	0.0021
Schistosoma mansoni	hypothetical protein	0.0038	0.0354	0.0411
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0089	0.0837
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0075
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.031	0.0259
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.0177	0.2635	0.2569
Brugia malayi	thymidylate kinase	0.0075	0.0969	0.1116
Trypanosoma cruzi	thymidine kinase, putative	0.0261	0.4005	1
Entamoeba histolytica	Thymidylate kinase, putative	0.0075	0.0969	0.1033
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0435	0.0496
Mycobacterium tuberculosis	Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase)	0.0053	0.0606	0.0598
Echinococcus granulosus	zinc finger protein	0.0021	0.0073	0.0065
Schistosoma mansoni	hypothetical protein	0.0054	0.0623	0.0723
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.023	0.0222
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.0759	0.0751
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0047	0.0507	0.1265
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0237	0.0174
Entamoeba histolytica	glycogen phosphorylase, putative	0.0235	0.3575	0.409
Loa Loa (eye worm)	thymidylate kinase	0.0075	0.0969	0.1116
Onchocerca volvulus		0.0053	0.0606	0.0428
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.064	0.0734
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0047	0.0507	0.1265
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.064	0.0743
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0507	0.049
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0249	0.024
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0507	0.049
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.035	0.0306
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0024	0.0124	0.0144
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0009	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0198	0.0127
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0009	0.0021
Echinococcus multilocularis	cytidine deaminase	0.0053	0.0606	0.0598
Trichomonas vaginalis	thymidylate kinase, putative	0.0075	0.0969	0.1033
Schistosoma mansoni	glycogen phosphorylase	0.0543	0.8611	1
Echinococcus granulosus	geminin	0.0539	0.8533	0.8532
Echinococcus multilocularis	thymidylate kinase	0.0075	0.0969	0.0961
Schistosoma mansoni	thymidylate kinase	0.0075	0.0969	0.1125
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0987	0.1138
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0047	0.0507	0.0499
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0947	0.1091
Echinococcus multilocularis	solute carrier family 28	0.034	0.5296	0.5292
Toxoplasma gondii	thymidylate kinase	0.0075	0.0969	1
Toxoplasma gondii	cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein	0.0053	0.0606	0.6224
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.035	0.0306
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0076
Echinococcus granulosus	glycogen phosphorylase	0.0543	0.8611	0.861
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0193	0.0122
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.064	0.0632
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0075	0.0969	0.0961
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0543	0.8611	1
Trypanosoma cruzi	thymidine kinase, putative	0.0261	0.4005	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0987	0.1147
Echinococcus multilocularis	zinc finger protein	0.0021	0.0073	0.0065
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0018	0.003	0.0021
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0075
Onchocerca volvulus	Putative thymidylate kinase	0.0075	0.0969	0.0861
Trichomonas vaginalis	set domain proteins, putative	0.0248	0.3788	0.4341
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0543	0.8611	0.861
Brugia malayi	Pre-SET motif family protein	0.0218	0.3296	0.3822
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.054	0.0532
Entamoeba histolytica	glycogenphosphorylase, putative	0.0235	0.3575	0.409
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0563	0.0645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0047	0.0507	0.049
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.003	0.0035
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0024	0.0124	0.0115
Schistosoma mansoni	hypothetical protein	0.0539	0.8533	0.991
Plasmodium falciparum	thymidylate kinase	0.0075	0.0969	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0198	0.0127
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0153	0.0075
Onchocerca volvulus		0.0051	0.0563	0.0376
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.004	0.0037
Brugia malayi	cytidine deaminase, identical	0.0053	0.0606	0.0695
Entamoeba histolytica	hypothetical protein	0.0038	0.0354	0.031
Brugia malayi	follicle stimulating hormone receptor	0.0245	0.3739	0.4336
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0089	0.0093
Schistosoma mansoni	ap endonuclease	0.0021	0.0089	0.0103
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0037	0.035	0.0874
Plasmodium vivax	SET domain protein, putative	0.0031	0.0249	0.2501
Leishmania major	thymidine kinase, putative	0.0261	0.4005	1
Echinococcus granulosus	glycogen phosphorylase	0.0543	0.8611	0.861
Trypanosoma cruzi	cytidine deaminase-like protein	0.0053	0.0606	0.1514
Brugia malayi	TAR-binding protein	0.0076	0.0987	0.1138
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0563	0.0654
Schistosoma mansoni	zinc finger protein	0.0021	0.0073	0.0085
Echinococcus granulosus	Na+ dependent nucleoside transporter	0.034	0.5296	0.5292
Entamoeba histolytica	hypothetical protein	0.0038	0.0354	0.031
Brugia malayi	Bromodomain containing protein	0.0079	0.1021	0.1176
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0035	0.031	0.3137
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0249	0.0289
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0047	0.0507	0.0499
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0038	0.0353	0.0344
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0089	0.008
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0987	0.1147
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0987	0.1138
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0089	0.0222
Trichomonas vaginalis	cytidine deaminase, putative	0.0053	0.0606	0.0607
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0089	0.0222
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0177	0.2635	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0037	0.035	0.0874
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.064	0.0632
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0018	0.003	0.0035
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.031	0.0259
Echinococcus multilocularis	glycogen phosphorylase	0.0543	0.8611	0.861
Schistosoma mansoni	hypothetical protein	0.0075	0.0969	0.1125
Mycobacterium ulcerans	thymidylate kinase	0.0075	0.0969	0.0888
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0047	0.0507	0.1265
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0022	0.0102	0.0254
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.031	0.0259
Brugia malayi	carbohydrate phosphorylase	0.0543	0.8611	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0218	0.3296	0.3822
Loa Loa (eye worm)	phosphatidylinositol 3	0.0047	0.0507	0.0579
Echinococcus multilocularis	glycogen phosphorylase	0.0543	0.8611	0.861
Toxoplasma gondii	exonuclease III APE	0.0021	0.0089	0.0837
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.054	0.0627
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0047	0.0507	0.1265
Trypanosoma brucei	cytidine deaminase	0.0053	0.0606	0.1514
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.035	0.0306
Trichomonas vaginalis	cytidine deaminase, putative	0.0053	0.0606	0.0607
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0987	0.1147
Echinococcus granulosus	survival motor neuron protein 1	0.0248	0.3781	0.3776
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0075	0.0969	0.1788
Echinococcus granulosus	cytidine deaminase	0.0053	0.0606	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.035	0.0306
Brugia malayi	hypothetical protein	0.0248	0.3781	0.4385
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0018	0.003	0.0021
Schistosoma mansoni	hypothetical protein	0.0539	0.8533	0.991
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0249	0.2501

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.122 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1533290

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1388101