Detailed information for compound 1391018

Basic information

Technical information
  • TDR Targets ID: 1391018
  • Name: N-(3-imidazol-1-ylpropyl)-3,5-dimethoxybenzam ide
  • MW: 289.33 | Formula: C15H19N3O3
  • H donors: 1 H acceptors: 2 LogP: 1.22 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)cc(c1)C(=O)NCCCn1cncc1
  • InChi: 1S/C15H19N3O3/c1-20-13-8-12(9-14(10-13)21-2)15(19)17-4-3-6-18-7-5-16-11-18/h5,7-11H,3-4,6H2,1-2H3,(H,17,19)
  • InChiKey: GSQLEAKXJONDKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-imidazol-1-ylpropyl)-3,5-dimethoxy-benzamide
  • N-[3-(1-imidazolyl)propyl]-3,5-dimethoxybenzamide
  • ASN 12270926
  • N-(3-Imidazol-1-yl-propyl)-3,5-dimethoxy-benzamide
  • MLS001208619
  • SMR000504391

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0155 0.0326
Mycobacterium tuberculosis Conserved hypothetical protein 0.0056 0.0299 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0114 0.0226
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0708 1
Trypanosoma brucei unspecified product 0.0039 0.0179 0.2316
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0439 0.3058
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0049 0.0342
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0019 0.0113
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0439 0.1123
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0301 0.1999 0.4049
Echinococcus multilocularis pyruvate kinase 0.0018 0.0037 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0151 0.0316
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0168 0.1078 0.3011
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0155 0.1972
Onchocerca volvulus 0.0076 0.0439 0.258
Schistosoma mansoni DNA helicase recq5 0.0021 0.0056 0.0037
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0037 0.0383
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0227 0.3015
Giardia lamblia Pyruvate kinase 0.0035 0.0155 0.0326
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0506 0.3421 0.9932
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0049 0.0061
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0708 0.4918
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0049 0.0656
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0016 0.0019 0.0013
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0439 0.3043
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0708 0.1653
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0214 0.0195
Loa Loa (eye worm) hypothetical protein 0.0076 0.0439 0.3043
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0032 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0197 0.0426
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0127 0.2379
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0439 0.1008
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0439 0.6097
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0103 0.0129
Echinococcus multilocularis pyruvate kinase 0.0035 0.0155 0.0149
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0127 0.0258
Chlamydia trachomatis transglycolase/transpeptidase 0.0356 0.2382 0.4807
Brugia malayi major facilitator superfamily protein 0.0016 0.0019 0.0136
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0151 0.1912
Onchocerca volvulus 0.0044 0.0214 0.1194
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.4185 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0493 0.688
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0063 0.0347 0.0964
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0013
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0017 0.0098
Mycobacterium ulcerans lipase LipD 0.0076 0.0439 0.0858
Echinococcus granulosus pyruvate kinase 0.0018 0.0037 0.003
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.033 0.0324
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0049 0.0042
Loa Loa (eye worm) hypothetical protein 0.0076 0.0439 0.3043
Brugia malayi beta-NAC-like protein 0.0035 0.0151 0.1052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Loa Loa (eye worm) hypothetical protein 0.0021 0.0056 0.0372
Treponema pallidum fructose-bisphosphate aldolase 0.0616 0.4185 0.6872
Brugia malayi Pre-SET motif family protein 0.0032 0.013 0.0909
Loa Loa (eye worm) hypothetical protein 0.0076 0.0439 0.3043
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0127 0.2379
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0049 0.0656
Echinococcus granulosus intermediate filament protein 0.0028 0.0109 0.0102
Plasmodium falciparum thioredoxin reductase 0.005 0.0258 0.5285
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0156 0.0327
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0056 0.0089
Plasmodium falciparum thioredoxin reductase 0.0017 0.0032 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0493 0.688
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0393 0.274
Loa Loa (eye worm) hypothetical protein 0.0032 0.0135 0.0922
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0056 0.0018
Loa Loa (eye worm) hypothetical protein 0.0081 0.0471 0.3266
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0056 0.0089
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0049 0.043
Onchocerca volvulus 0.0076 0.0439 0.258
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0155 0.0835
Brugia malayi hypothetical protein 0.0016 0.0019 0.0136
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0439 0.1234
Echinococcus multilocularis neuropeptide s receptor 0.0489 0.3303 0.3298
Brugia malayi Flap endonuclease-1 0.0028 0.0103 0.0714
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0127 0.2379
Brugia malayi intermediate filament protein 0.0028 0.0109 0.0756
Echinococcus granulosus lamin dm0 0.0028 0.0109 0.0102
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0155 0.1061
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0059 0.0116
Echinococcus multilocularis dna polymerase kappa 0.0084 0.0493 0.0487
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0059 0.0243
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.033 0.0636
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.013 0.0111
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0227 0.3015
Schistosoma mansoni rotamase 0.0035 0.0156 0.0136
Echinococcus granulosus neuropeptide receptor A26 0.0489 0.3303 0.3298
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0056 0.0089
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0439 0.1008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0439 0.0421
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0032 0.018
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0393 0.2724
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0059 0.041
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0151 0.2915
Echinococcus granulosus dna polymerase eta 0.0083 0.0485 0.0478
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0258
Loa Loa (eye worm) sugar transporter 0.0016 0.0019 0.0113
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0439 0.9293
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.013 0.2458
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0056 0.0393
Echinococcus granulosus transcription factor Dp 1 0.004 0.0191 0.0184
Echinococcus multilocularis chromobox protein 1 0.0073 0.042 0.0414
Echinococcus granulosus pyruvate kinase 0.0018 0.0037 0.003
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.015 0.1894
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0393 0.0387
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0227 0.3015
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0056 0.0819
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0439 0.6097
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0056 0.005
Leishmania major DNA polymerase kappa, putative 0.0017 0.0032 0.0183
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0127 0.2379
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0218 0.0478
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0049 0.0042
Echinococcus granulosus bloom syndrome protein 0.0021 0.0056 0.005
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0032 0.0025
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0103 0.0096
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0155 0.0326
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0056 0.0537
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0103 0.0199
Leishmania major trypanothione reductase 0.005 0.0258 0.3467
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0155 0.0399
Schistosoma mansoni transcription factor btf3 0.0035 0.0151 0.0132
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0032 0.018
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0115 0.0708 1
Echinococcus granulosus expressed protein 0.0035 0.0156 0.0149
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0013
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0218 0.1223
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.018 0.1163 0.3261
Echinococcus granulosus pyruvate kinase 0.0018 0.0037 0.003
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.015 0.1894
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0708 0.1593
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0171 0.1101 0.3179
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0463 0.3122 0.9121
Loa Loa (eye worm) hypothetical protein 0.0024 0.0082 0.0547
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0081 0.0471 0.3281
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0151 0.1032
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0032 0.018
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0471 1
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0258 0.0251
Leishmania major DNA polymerase eta, putative 0.0083 0.0485 0.6762
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0358 0.2395 0.4858
Brugia malayi SET domain containing protein 0.0013 0.0003 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0493 0.688
Echinococcus multilocularis chromobox protein 1 0.0073 0.042 0.0414
Brugia malayi Heterochromatin protein 1 0.0073 0.042 0.2926
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.015 0.1894
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0103 0.0693
Echinococcus multilocularis lamin dm0 0.0028 0.0109 0.0102
Mycobacterium ulcerans hypothetical protein 0.0017 0.0032 0.0026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.4185 1
Echinococcus multilocularis pyruvate kinase 0.0018 0.0037 0.003
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0056 0.0393
Brugia malayi hypothetical protein 0.0016 0.0019 0.0136
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0393 0.5433
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0049 0.032
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0032 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0493 0.688
Onchocerca volvulus 0.0076 0.0439 0.258
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0103 0.0199
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0082 0.0079
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0439 0.1234
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.018
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0708 0.069
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0226 0.3001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0493 0.688
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.033 0.0324
Brugia malayi glutathione reductase 0.005 0.0258 0.1798
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.013 0.0111
Brugia malayi polk-prov protein 0.0045 0.0226 0.1574
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0049 0.006
Echinococcus granulosus chromobox protein 1 0.0073 0.042 0.0414
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0509 0.3444 1
Onchocerca volvulus 0.0028 0.0109 0.0548
Brugia malayi beta-lactamase family protein 0.0076 0.0439 0.3058
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0032 0.0183
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0019 0.0113
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0439 0.1234
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0019 0.0136
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0032 0.0025
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0032 0.0183
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0258 0.0251
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0032 0.0025
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0056 0.0819
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.013 0.0124
Loa Loa (eye worm) sugar transporter 0.0016 0.0019 0.0113
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0702 0.2006
Schistosoma mansoni hypothetical protein 0.0346 0.2308 0.2293
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0151 0.0316
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0049 0.043
Brugia malayi beta-lactamase family protein 0.0076 0.0439 0.3058
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0155 0.0835
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0032 0.0274
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0032 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.018
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0127 0.0194
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0393 0.5433
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0151 0.2915
Entamoeba histolytica hypothetical protein 0.0035 0.0151 0.0247
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0493 0.688
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0032 0.0274
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0191 0.0184
Trypanosoma brucei DNA polymerase IV, putative 0.0077 0.0445 0.6181
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0084 0.0493 0.1137
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0032 0.018
Mycobacterium tuberculosis Conserved protein 0.0076 0.0439 0.1234
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0218 0.2882
Trypanosoma brucei trypanothione reductase 0.005 0.0258 0.3467
Giardia lamblia DINP protein human, muc B family 0.0063 0.0347 0.0787
Brugia malayi ImpB/MucB/SamB family protein 0.0056 0.0299 0.2083
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0439 0.1008
Onchocerca volvulus 0.025 0.1646 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0393 0.0387
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.008 0.1344
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0471 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Trypanosoma brucei unspecified product 0.0077 0.0445 0.6181
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0056 0.005
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0019 0.0013
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.033 0.0636
Trypanosoma brucei DNA polymerase kappa, putative 0.0063 0.0347 0.4761
Trichomonas vaginalis DNA polymerase eta, putative 0.0084 0.0493 0.1137
Echinococcus granulosus flap endonuclease 1 0.0028 0.0103 0.0096
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0032 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.013 0.0111
Giardia lamblia Pyruvate kinase 0.0018 0.0037 0.0042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.018
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0056 0.0537
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0032 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0439 0.1008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.018
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0056 0.005
Plasmodium vivax SET domain protein, putative 0.0032 0.013 0.2458
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.4185 1
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0708 0.1653
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0155 0.0835
Plasmodium falciparum glutathione reductase 0.005 0.0258 0.5285
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.022 0.1436 1
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0358 0.2395 0.6984
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0155 0.1972
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0151 0.0316
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.079 0.2265
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0463 0.3122 0.9049
Echinococcus granulosus Solute carrier family 22 5 0.1093 0.7492 0.749
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0063 0.0347 0.4761
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0156 0.1083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0032 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.018
Brugia malayi major facilitator superfamily protein 0.0016 0.0019 0.0136
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0032 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0493 0.688
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0056 0.0819
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0702 0.2006
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0056 0.0819
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0155 0.1972
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0127 0.2379
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0302 0.2087
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0049 0.043
Leishmania major hypothetical protein, conserved 0.0076 0.0439 0.6097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.018
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.079 0.2265
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0439 0.0433
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.042 0.291
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0168 0.1078 0.3112
Treponema pallidum hypothetical protein 0.0168 0.1078 0.1731
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0109 0.0736
Loa Loa (eye worm) hypothetical protein 0.0083 0.0485 0.3362
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.0493 0.0969
Toxoplasma gondii ABC1 family protein 0.0076 0.0439 0.9293
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0032 0.0183
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0151 0.2915
Mycobacterium ulcerans hypothetical protein 0.0021 0.0059 0.0081
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Loa Loa (eye worm) glutathione reductase 0.005 0.0258 0.1779
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0702 0.1899
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0019 0.0136
Trichomonas vaginalis rotamase, putative 0.0034 0.015 0.0313
Brugia malayi Sugar transporter family protein 0.0016 0.0019 0.0136
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0258
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0723 0.4922 1
Echinococcus multilocularis expressed protein 0.0035 0.0156 0.0149
Mycobacterium tuberculosis Conserved protein 0.0076 0.0439 0.1234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Loa Loa (eye worm) 6-phosphofructokinase 0.0115 0.0708 0.4918
Echinococcus granulosus pyruvate kinase 0.0035 0.0155 0.0149
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0032 0.0013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0393 0.5433
Echinococcus granulosus chromobox protein 1 0.0073 0.042 0.0414
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0393 0.5433
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0032 0.0278
Onchocerca volvulus 0.0032 0.0135 0.0712
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0439 0.0858
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0258 0.5285
Mycobacterium tuberculosis Probable reductase 0.0114 0.0702 0.2006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0059 0.0389
Schistosoma mansoni pyruvate kinase 0.0018 0.0037 0.0017
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.033 0.4517
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0103 0.184
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0439 0.6097
Echinococcus multilocularis neuropeptide receptor A26 0.0489 0.3303 0.3298
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0025
Loa Loa (eye worm) hypothetical protein 0.0041 0.0197 0.1351
Loa Loa (eye worm) hypothetical protein 0.0028 0.0109 0.0736
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.018 0.1163 0.3361
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Toxoplasma gondii exonuclease III APE 0.002 0.0049 0.0656
Leishmania major DNA damage repair protein, putative 0.0017 0.0032 0.0183
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0506 0.3421 0.6956
Loa Loa (eye worm) phosphofructokinase 0.0115 0.0708 0.4918
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0155 0.1081
Echinococcus multilocularis pyruvate kinase 0.0035 0.0155 0.0149
Loa Loa (eye worm) RecQ helicase 0.0021 0.0056 0.0372
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0032 0.0274
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0439 0.1234
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0032 0.0274
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.033 0.0914
Plasmodium falciparum glutathione reductase 0.0017 0.0032 0.0274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.4185 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0127 0.0157
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0258
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0151 0.1912
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Schistosoma mansoni ap endonuclease 0.002 0.0049 0.003
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0258
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0032 0.0025
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.079 0.2265
Schistosoma mansoni lamin 0.0028 0.0109 0.0089
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0155 0.1061
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0493 0.688
Mycobacterium ulcerans DNA polymerase IV 0.0084 0.0493 0.0969
Trichomonas vaginalis conserved hypothetical protein 0.0509 0.3444 0.8221
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0151 0.0247
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0049 0.0071
Brugia malayi phosphofructokinase 0.0115 0.0708 0.493
Mycobacterium ulcerans hypothetical protein 0.0076 0.0439 0.0858
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0506 0.3421 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0032 0.018
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0463 0.3122 0.6345
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0049 0.0071
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0056 0.0372
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.013 0.0124
Echinococcus multilocularis dna polymerase eta 0.0083 0.0485 0.0478
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0122 0.0116
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.079 0.216
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0056 0.005
Toxoplasma gondii endonuclease IV APN 0.0081 0.0471 1
Treponema pallidum penicillin-binding protein (pbp-1) 0.0723 0.4922 0.8091
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0017 0.012
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0032 0.018
Treponema pallidum penicillin-binding protein (pbp-3) 0.0889 0.6075 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0056 0.0299 0.028
Schistosoma mansoni ap endonuclease 0.002 0.0049 0.003
Giardia lamblia DNA damage repair protein 0.0017 0.0032 0.003
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0151 0.1912
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0439 0.1008
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0032 0.003
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0103 0.1207
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0439 0.1234
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0019 0.0013
Mycobacterium ulcerans epimerase 0.0021 0.0059 0.0081
Echinococcus multilocularis musashi 0.0028 0.0109 0.0102
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0049 0.043
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0019 0.0013
Loa Loa (eye worm) hypothetical protein 0.0076 0.0439 0.3043
Mycobacterium leprae Probable lipase LipE 0.0076 0.0439 0.1123
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0168 0.1078 0.2165
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0115 0.0708 0.1917
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0616 0.4185 1
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0439 0.0858
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0032 0.0274
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0049 0.0087
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0103 0.1207
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0258 0.1779
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0056 0.005
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0032 0.0036
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0032 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0197 0.0426
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0708 0.1653
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0049 0.0028
Chlamydia trachomatis transglycolase/transpeptidase 0.0723 0.4922 1
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0081 0.0471 0.1218
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0155 0.3006
Brugia malayi ImpB/MucB/SamB family protein 0.0083 0.0485 0.3377
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.015 0.2886
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0493 0.688
Trypanosoma brucei unspecified product 0.0039 0.0179 0.2316
Loa Loa (eye worm) beta-lactamase 0.0076 0.0439 0.3043
Brugia malayi 6-phosphofructokinase 0.0115 0.0708 0.493
Schistosoma mansoni pyruvate kinase 0.0035 0.0155 0.0136
Schistosoma mansoni chromobox protein 0.0073 0.042 0.0401
Schistosoma mansoni chromobox protein 0.0073 0.042 0.0401
Brugia malayi Sugar transporter family protein 0.0016 0.0019 0.0136
Loa Loa (eye worm) hypothetical protein 0.0076 0.0439 0.3043
Plasmodium vivax glutathione reductase, putative 0.005 0.0258 0.5285
Brugia malayi Thioredoxin reductase 0.005 0.0258 0.1798
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0109 0.0736
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0393 0.0833
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.015 0.1894
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.0485 0.6762
Leishmania major ATP-dependent phosphofructokinase 0.0115 0.0708 1
Echinococcus granulosus geminin 0.0346 0.2308 0.2302
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0049 0.0071
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0439 0.1234
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0115 0.0708 0.2024
Mycobacterium ulcerans beta-lactamase 0.0076 0.0439 0.0858
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0155 0.0285
Schistosoma mansoni DNA polymerase eta 0.0083 0.0485 0.0466
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0218 0.4394
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0708 0.1593
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0127 0.0188
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0616 0.4185 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0127 0.0258
Trichomonas vaginalis rotamase, putative 0.0035 0.0156 0.0327
Schistosoma mansoni 6-phosphofructokinase 0.0115 0.0708 0.069
Treponema pallidum penicillin-binding protein (pbp-2) 0.0509 0.3444 0.5646
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0155 0.1972
Mycobacterium ulcerans 6-phosphofructokinase 0.0115 0.0708 0.1408
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Mycobacterium ulcerans endonuclease IV 0.0081 0.0471 0.0924
Chlamydia trachomatis pyruvate kinase 0.0035 0.0155 0.0252
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0032 0.018
Trichomonas vaginalis chromobox protein, putative 0.0073 0.042 0.0962
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.033 0.2301
Echinococcus granulosus pyruvate kinase 0.0035 0.0155 0.0149
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0258 0.0702
Schistosoma mansoni hypothetical protein 0.0346 0.2308 0.2293
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0439 0.0433
Schistosoma mansoni lamin 0.0028 0.0109 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0493 0.688
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0358 0.2395 0.6902
Loa Loa (eye worm) hypothetical protein 0.0032 0.013 0.0888
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0037 0.0383
Giardia lamblia Fructose-bisphosphate aldolase 0.0616 0.4185 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.4185 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0702 0.2006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0084 0.0493 0.688
Brugia malayi 6-phosphofructokinase 0.0115 0.0708 0.493
Brugia malayi beta-lactamase 0.0076 0.0439 0.3058
Echinococcus multilocularis geminin 0.0346 0.2308 0.2302
Entamoeba histolytica phosphofructokinase, putative 0.0115 0.0708 0.1593
Loa Loa (eye worm) hypothetical protein 0.0035 0.0155 0.1061
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0439 0.0421
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0218 0.0478
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.033 0.0312
Trichomonas vaginalis phosphofructokinase, putative 0.0115 0.0708 0.1653
Loa Loa (eye worm) hypothetical protein 0.0045 0.0226 0.1555
Trichomonas vaginalis esterase, putative 0.0076 0.0439 0.1008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0032 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0114 0.0226
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0439 0.1234
Echinococcus granulosus dna polymerase kappa 0.0084 0.0493 0.0487
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0056 0.0299 0.028
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0721 0.4909 1
Brugia malayi hypothetical protein 0.0016 0.0019 0.0136
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0155 0.3006
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0155 0.1061
Echinococcus granulosus neuropeptide s receptor 0.0489 0.3303 0.3298
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0032 0.0012
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0081 0.0471 0.1328
Echinococcus multilocularis pyruvate kinase 0.0018 0.0037 0.003
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Entamoeba histolytica deoxycytidyl transferase, putative 0.0056 0.0299 0.0605
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0226 0.3001
Plasmodium falciparum pyruvate kinase 0.0035 0.0155 0.3006
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0393 0.0375
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0032 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0493 0.688
Echinococcus multilocularis transcription factor btf3 0.0035 0.0151 0.0144
Leishmania major DNA polymerase eta, putative 0.0044 0.0218 0.2882
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0032 0.0183
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0509 0.3444 0.7003
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0103 0.184
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0258 0.3467
Schistosoma mansoni intermediate filament proteins 0.0028 0.0109 0.0089
Mycobacterium tuberculosis Conserved protein 0.0076 0.0439 0.1234
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0156 0.1063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Echinococcus multilocularis microtubule associated protein 2 0.1455 1 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0082 0.0547
Trichomonas vaginalis chromobox protein, putative 0.0073 0.042 0.0962
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0056 0.0393
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0115 0.0708 0.1119
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0032 0.018
Trichomonas vaginalis set domain proteins, putative 0.025 0.1646 0.3906
Echinococcus multilocularis pyruvate kinase 0.0028 0.0104 0.0097
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Echinococcus multilocularis lamin 0.0028 0.0109 0.0102
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0103 0.1207
Schistosoma mansoni flap endonuclease-1 0.0025 0.0084 0.0065
Echinococcus multilocularis 6 phosphofructokinase 0.0115 0.0708 0.0702
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Chlamydia trachomatis endonuclease IV 0.0081 0.0471 0.0898
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0702 0.2006
Trypanosoma brucei DNA polymerase kappa, putative 0.0084 0.0493 0.688
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0702 0.2006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.013 0.0124
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0301 0.1999 0.5732
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0013
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0486 0.3281 0.9588
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0056 0.0537
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0032 0.0183
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0056 0.0299 0.0292
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0032 0.0183
Plasmodium falciparum flap endonuclease 1 0.0028 0.0103 0.184
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0109 0.0756
Echinococcus granulosus lamin 0.0028 0.0109 0.0102
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0155 0.0278
Leishmania major pyruvate kinase 0.0035 0.0155 0.1972
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0127 0.0194
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0127 0.2379
Echinococcus multilocularis solute carrier family 22 0.0016 0.0019 0.0013
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0019 0.0013
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Brugia malayi Sugar transporter family protein 0.0016 0.0019 0.0136
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0032 0.0183
Leishmania major basic transcription factor 3a, putative 0.0035 0.0151 0.1912
Echinococcus granulosus solute carrier family 22 0.0016 0.0019 0.0013
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0019 0.0013
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0056 0.0299 0.0292
Leishmania major DNA polymerase kappa, putative 0.0063 0.0347 0.4761
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0493 0.688
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0019 0.0136
Trypanosoma brucei DNA polymerase eta, putative 0.0083 0.0485 0.6762
Loa Loa (eye worm) hypothetical protein 0.0028 0.0105 0.0711
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0127 0.0258
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.015 0.0244
Schistosoma mansoni pyruvate kinase 0.0035 0.0155 0.0136
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0032 0.0274
Leishmania major pyruvate kinase 0.0035 0.0155 0.1972
Trypanosoma brucei DNA polymerase IV, putative 0.0084 0.0493 0.688
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.4185 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0197 0.109
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0301 0.1999 0.582
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0037 0.0383
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.4185 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0032 0.0025
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0059 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0616 0.4185 1
Toxoplasma gondii thioredoxin reductase 0.005 0.0258 0.5285
Loa Loa (eye worm) hypothetical protein 0.0076 0.0439 0.3043
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0056 0.0299 0.2065
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0127 0.2379
Echinococcus granulosus transcription factor btf3 0.0035 0.0151 0.0144
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0113
Schistosoma mansoni DNA helicase recq1 0.0021 0.0056 0.0037
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0155 0.1081
Brugia malayi chromobox protein homolog 3 0.0041 0.0197 0.1371
Schistosoma mansoni microtubule-associated protein tau 0.1455 1 1
Onchocerca volvulus 0.0028 0.0109 0.0548
Brugia malayi Pre-SET motif family protein 0.022 0.1436 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0032 0.0183
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0056 0.0089
Echinococcus granulosus 6 phosphofructokinase 0.0115 0.0708 0.0702

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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