Detailed information for compound 1391832

Basic information

Technical information
  • TDR Targets ID: 1391832
  • Name: 3,4-dimethyl-2-(morpholin-4-ylmethyl)-6-(1-ph enylethyl)phenol
  • MW: 325.445 | Formula: C21H27NO2
  • H donors: 1 H acceptors: 1 LogP: 4.01 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1c(C)cc(c(c1CN1CCOCC1)O)C(c1ccccc1)C
  • InChi: 1S/C21H27NO2/c1-15-13-19(17(3)18-7-5-4-6-8-18)21(23)20(16(15)2)14-22-9-11-24-12-10-22/h4-8,13,17,23H,9-12,14H2,1-3H3
  • InChiKey: DHODRICJAWWBRG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dimethyl-2-(morpholinomethyl)-6-(1-phenylethyl)phenol
  • MLS000064176
  • SMR000076114
  • A3385/0143609
  • 3,4-dimethyl-2-(4-morpholinylmethyl)-6-(1-phenylethyl)phenol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens mucolipin 3 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) mucolipin 1 Get druggable targets OG5_129484 All targets in OG5_129484
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus mucolipin 3 Get druggable targets OG5_129484 All targets in OG5_129484
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum expressed protein Get druggable targets OG5_129484 All targets in OG5_129484
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni mucolipin Get druggable targets OG5_129484 All targets in OG5_129484
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Coelomocyte uptake defective protein 5 Get druggable targets OG5_129484 All targets in OG5_129484
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis mucolipin 3 Get druggable targets OG5_129484 All targets in OG5_129484
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04994 mucolipin 3, putative Get druggable targets OG5_129484 All targets in OG5_129484
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni mucolipin Get druggable targets OG5_129484 All targets in OG5_129484
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0943 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0669 0.699 0.6949
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0389 0.3921 0.3837
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0146 0.0146
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0136 0.0048
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0655 0.0655
Onchocerca volvulus 0.0091 0.0655 0.2248
Giardia lamblia Transcriptional regulator, Sir2 family 0.0389 0.3921 0.3921
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0365 0.0365
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0088 0.0088
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0147 0.1271 0.3074
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0077 0.0502 0.0371
Giardia lamblia Sirtuin type 2 0.0242 0.2312 0.2312
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0943 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0051 0.0216 0.0552
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Schistosoma mansoni tyrosinase precursor 0.0091 0.0655 0.0655
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0146 0.0059
Loa Loa (eye worm) sirtuin 4 0.0242 0.2312 0.2312
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0317 0.0317
Brugia malayi Coelomocyte uptake defective protein 5 0.0079 0.0521 0.0521
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0088 0.0088
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0586 0.6083 0.6048
Schistosoma mansoni inositol monophosphatase 0.0045 0.0146 0.0146
Schistosoma mansoni mucolipin 0.0079 0.0521 0.0521
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.006 0.0317 0.0317
Schistosoma mansoni chromatin regulatory protein sir2 0.0389 0.3921 0.3921
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1814 0.1814
Treponema pallidum NADH oxidase 0.0051 0.0216 0.5
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0088 0.0088
Brugia malayi PXA domain containing protein 0.0039 0.0088 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0263 0.0263
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0389 0.3921 0.3867
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0655 0.0655
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0088 0.0088
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0297 0.2913 0.2913
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0943 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0452 0.0452
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0317 0.0317
Mycobacterium tuberculosis Probable oxidoreductase 0.0373 0.3749 0.9551
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0336 0.3338 0.8477
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.578 0.578
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0146 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0242 0.2312 0.5896
Entamoeba histolytica serine/threonine protein kinase, putative 0.0297 0.2913 0.285
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0099 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Leishmania major silent information regulator 2, putative 0.0943 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0263 0.0263
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0389 0.3921 0.3867
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0136 0.0048
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0586 0.6083 0.6048
Echinococcus granulosus thioredoxin glutathione reductase 0.0147 0.1271 0.1271
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0072 0.0072
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0088 0.0088
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0051 0.0216 0.0082
Onchocerca volvulus Serine\/threonine kinase homolog 0.0297 0.2913 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.078 0.078
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0077 0.0502 0.1063
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0077 0.0502 0.0618
Loa Loa (eye worm) hypothetical protein 0.0344 0.3428 0.3428
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0088 0.0088
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0051 0.0216 0.0082
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0549 0.0549
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0136 0.0136
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0051 0.0216 0.0122
Mycobacterium ulcerans glutaminase 0.0569 0.5898 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Loa Loa (eye worm) transcriptional regulator 0.0242 0.2312 0.2312
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0068 0.0068
Loa Loa (eye worm) glutathione reductase 0.0147 0.1271 0.1271
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.578 0.578
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0051 0.0216 0.0552
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0082
Loa Loa (eye worm) RNA binding protein 0.0065 0.0373 0.0373
Trypanosoma cruzi polo-like protein kinase, putative 0.0297 0.2913 0.2816
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0242 0.2312 0.2312
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0655 0.0655
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0943 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0586 0.6083 0.6083
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Brugia malayi RNA binding protein 0.0065 0.0373 0.0373
Onchocerca volvulus 0.0091 0.0655 0.2248
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0091 0.0655 0.0655
Trypanosoma cruzi hypothetical protein, conserved 0.0669 0.699 0.6949
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0373 0.0373
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0389 0.3921 0.3867
Loa Loa (eye worm) thioredoxin reductase 0.0147 0.1271 0.1271
Schistosoma mansoni mucolipin 0.0072 0.0448 0.0448
Schistosoma mansoni chromatin regulatory protein sir2 0.0943 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0051 0.0216 0.0122
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.2913 0.2913
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0099 0.0099
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0452 0.0367
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0099 0.0099
Giardia lamblia Hypothetical protein 0.0943 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0088 0.0088
Leishmania major sir2-family protein-like protein 0.0242 0.2312 0.2206
Brugia malayi transcriptional regulator, Sir2 family protein 0.0242 0.2312 0.2312
Schistosoma mansoni chromatin regulatory protein sir2 0.0242 0.2312 0.2312
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0216
Loa Loa (eye worm) tyrosinase 1 0.0091 0.0655 0.0655
Brugia malayi Common central domain of tyrosinase family protein 0.0091 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0146 0.0059
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0263 0.0263
Trypanosoma brucei SIR2-like protein 4, putative 0.0242 0.2312 0.2206
Leishmania major trypanothione reductase 0.0147 0.1271 0.1151
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0586 0.6083 0.6083
Loa Loa (eye worm) glutaminase 0.0569 0.5898 0.5898
Schistosoma mansoni alpha-glucosidase 0.0169 0.1514 0.1514
Plasmodium vivax glutathione reductase, putative 0.0147 0.1271 0.3241
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0586 0.6083 0.6048
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0373 0.3749 0.9551
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0297 0.2913 0.2913
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0146 0.0011
Trypanosoma brucei trypanothione reductase 0.0147 0.1271 0.1151
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0146 0.0146
Echinococcus granulosus citrate lyase subunit beta protein 0.0077 0.0502 0.0502
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0077 0.0502 0.0618
Echinococcus multilocularis mucolipin 3 0.0079 0.0521 0.0521
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0136 0.0048
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0452 0.0367
Echinococcus multilocularis citrate lyase subunit beta protein 0.0077 0.0502 0.0502
Toxoplasma gondii thioredoxin reductase 0.0147 0.1271 0.3241
Loa Loa (eye worm) transcriptional regulator 0.0943 1 1
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0088 0.0088
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0077 0.0502 0.0417
Brugia malayi jmjC domain containing protein 0.0038 0.0072 0.0072
Mycobacterium tuberculosis Probable reductase 0.0336 0.3338 0.8477
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0077 0.0502 0.0618
Toxoplasma gondii histone deacetylase SIR2-like 0.0242 0.2312 0.5896
Echinococcus multilocularis chromobox protein 1 0.0073 0.0452 0.0452
Giardia lamblia NADH oxidase lateral transfer candidate 0.0051 0.0216 0.0216
Loa Loa (eye worm) hypothetical protein 0.0586 0.6083 0.6083
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0077 0.0502 0.0371
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0146 0.0059
Trichomonas vaginalis mercuric reductase, putative 0.0051 0.0216 0.0129
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0099 0.0099
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0077 0.0502 0.0371
Loa Loa (eye worm) glutaminase 2 0.0569 0.5898 0.5898
Schistosoma mansoni hypothetical protein 0.0205 0.1901 0.1901
Loa Loa (eye worm) hypothetical protein 0.0041 0.0103 0.0103
Mycobacterium ulcerans hypothetical protein 0.0077 0.0502 0.0618
Plasmodium falciparum thioredoxin reductase 0.0051 0.0216 0.0552
Schistosoma mansoni chromatin regulatory protein sir2 0.0242 0.2312 0.2312
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0297 0.2913 0.2913
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0336 0.3338 0.8876
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0068 0.0068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0136 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1269 0.1191
Brugia malayi TAR-binding protein 0.0065 0.0373 0.0373
Leishmania major hypothetical protein, conserved 0.0669 0.699 0.6949
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0136 0.0048
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0586 0.6083 0.6083
Brugia malayi Thioredoxin reductase 0.0147 0.1271 0.1271
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0242 0.2312 0.2312
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1814 0.1814
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0088 0.0088
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0134 0.0134
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0263 0.0263
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0216 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0051 0.0216 0.0552
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0137 0.047
Echinococcus multilocularis thioredoxin glutathione reductase 0.0147 0.1271 0.1271
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0137 0.0049
Plasmodium falciparum glutathione reductase 0.0147 0.1271 0.3241
Brugia malayi Heterochromatin protein 1 0.0073 0.0452 0.0452
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0242 0.2312 0.2312
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0099 0.0099
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0051 0.0216 0.0216
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0088 0.0088
Echinococcus multilocularis expressed protein 0.0766 0.805 0.805
Onchocerca volvulus 0.0032 0.0007 0.0023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1814 0.1814
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0082
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0373 0.0373
Schistosoma mansoni chromatin regulatory protein sir2 0.0943 1 1
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0088 0.0088
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0051 0.0216 0.0552
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0072 0.0072
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0072 0.0072
Echinococcus granulosus tar DNA binding protein 0.0065 0.0373 0.0373
Mycobacterium ulcerans Sir2-like regulatory protein 0.0242 0.2312 0.3766
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0389 0.3921 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0245 0.0245
Schistosoma mansoni chromatin regulatory protein sir2 0.0943 1 1
Onchocerca volvulus 0.0114 0.0905 0.3106
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0373 0.0373
Schistosoma mansoni chromobox protein 0.0073 0.0452 0.0452
Mycobacterium tuberculosis Probable dehydrogenase 0.0336 0.3338 0.8477
Toxoplasma gondii histone deacetylase SIR2 0.0389 0.3921 1
Trypanosoma brucei polo-like protein kinase 0.0297 0.2913 0.2816
Brugia malayi PXA domain containing protein 0.0039 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0108
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0072 0.0072
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0943 1 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0216 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0586 0.6083 0.6083
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0216 0.0082
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0088 0.0088
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0088 0.0088
Schistosoma mansoni hypothetical protein 0.0041 0.0108 0.0108
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0263 0.0263
Trichomonas vaginalis glutathione reductase, putative 0.0051 0.0216 0.0129
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Onchocerca volvulus 0.0091 0.0655 0.2248
Plasmodium falciparum glutathione reductase 0.0051 0.0216 0.0552
Schistosoma mansoni inositol monophosphatase 0.0045 0.0146 0.0146
Plasmodium falciparum thioredoxin reductase 0.0147 0.1271 0.3241
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0943 1 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0242 0.2312 0.2244
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0136 0.0048
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1814 0.1814
Trypanosoma cruzi hypothetical protein, conserved 0.0669 0.699 0.6949
Brugia malayi chromobox protein homolog 3 0.0041 0.0103 0.0103
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0088 0.0088
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0336 0.3338 0.8477
Schistosoma mansoni glutaminase 0.0569 0.5898 0.5898
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0216
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0088 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0072 0.0072
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0336 0.3338 0.8477
Plasmodium vivax NAD-dependent deacetylase, putative 0.0389 0.3921 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0051 0.0216 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0242 0.2312 0.5896
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0389 0.3921 0.3867
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0943 1 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0146 0.0059
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0146 0.0373
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0099 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Onchocerca volvulus 0.0091 0.0655 0.2248
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0655 0.0655
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0088 0.0088
Echinococcus granulosus chromatin regulatory protein sir2 0.0943 1 1
Loa Loa (eye worm) transcriptional regulator 0.0242 0.2312 0.2312
Echinococcus multilocularis chromobox protein 1 0.0073 0.0452 0.0452
Schistosoma mansoni alpha glucosidase 0.0044 0.0136 0.0136
Brugia malayi jmjC domain containing protein 0.0102 0.078 0.078
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Schistosoma mansoni chromobox protein 0.0073 0.0452 0.0452
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0099 0.0099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0263 0.0263
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0242 0.2312 0.2244
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0088 0.0088
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0147 0.1266 0.3206
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0242 0.2312 0.2244
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0263 0.0263
Schistosoma mansoni alpha-glucosidase 0.0169 0.1514 0.1514
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0088 0.0088
Trypanosoma cruzi polo-like protein kinase, putative 0.0297 0.2913 0.2816
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0134 0.0134
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0051 0.0216 0.0082
Schistosoma mansoni hypothetical protein 0.0205 0.1901 0.1901
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0136 0.0136
Giardia lamblia Kinase, PLK 0.0297 0.2913 0.2913
Trypanosoma cruzi trypanothione reductase, putative 0.0147 0.1271 0.1151
Mycobacterium ulcerans hypothetical protein 0.0077 0.0502 0.0618
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0389 0.3921 0.3837
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0389 0.3921 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0088 0.0088
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0088 0.0088
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0242 0.2312 0.2312
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Brugia malayi NAD-dependent deacetylase SIRT1 0.0586 0.6083 0.6083
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0389 0.3921 0.3837
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0263 0.0263
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0051 0.0216 0.0317
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0088 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0103 0.0015
Schistosoma mansoni tyrosinase precursor 0.0091 0.0655 0.0655
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0088 0.0088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0146 0.0011
Brugia malayi Inositol-1 0.0045 0.0146 0.0146
Loa Loa (eye worm) mucolipin 1 0.0079 0.0521 0.0521
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0088 0.0088
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0051 0.0216 0.0082
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0586 0.6083 0.6048
Echinococcus granulosus chromobox protein 1 0.0073 0.0452 0.0452
Brugia malayi hypothetical protein 0.0039 0.0088 0.0088
Echinococcus granulosus chromobox protein 1 0.0073 0.0452 0.0452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0103 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Loa Loa (eye worm) hypothetical protein 0.0091 0.0655 0.0655
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0943 1 1
Echinococcus granulosus neuropeptide s receptor 0.0558 0.578 0.578
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Echinococcus granulosus expressed protein 0.0766 0.805 0.805
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0943 1 1
Brugia malayi glutathione reductase 0.0147 0.1271 0.1271
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.078 0.078
Loa Loa (eye worm) inositol-1 0.0045 0.0146 0.0146
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0373 0.3749 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0136 0.0347
Echinococcus granulosus mucolipin 3 0.0079 0.0521 0.0521
Echinococcus multilocularis chromatin regulatory protein sir2 0.0943 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0136 0.0048
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.578 0.578
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0336 0.3338 0.8477
Toxoplasma gondii NADPH-glutathione reductase 0.0051 0.0216 0.0552
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0091 0.0655 0.0655
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0088 0.0088
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0389 0.3921 0.3837
Entamoeba histolytica hypothetical protein, conserved 0.0242 0.2312 0.2244
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0136 0.0136
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Brugia malayi transcriptional regulator, Sir2 family protein 0.0242 0.2312 0.2312
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0297 0.2913 0.2816
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0099 0.0099
Brugia malayi serine/threonine-protein kinase plk-2 0.0297 0.2913 0.2913
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Brugia malayi hypothetical protein 0.0039 0.0088 0.0088
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0137 0.0049
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0655 0.0655
Echinococcus granulosus geminin 0.0205 0.1901 0.1901
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0373 0.0373
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0216 0.0082
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0088 0.0088
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0088 0.0088
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0373 0.3749 0.9551
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0317 0.0317
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0051 0.0216 0.0552
Plasmodium vivax thioredoxin reductase, putative 0.0147 0.1271 0.3241
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1269 0.1191
Trichomonas vaginalis glutaminase, putative 0.0569 0.5898 0.5861
Mycobacterium tuberculosis Conserved protein 0.0077 0.0502 0.1063
Brugia malayi ShTK domain containing protein 0.0091 0.0655 0.0655
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0088 0.0088
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0122
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0146 0.0011
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0088 0.0088
Echinococcus multilocularis geminin 0.0205 0.1901 0.1901
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1814 0.1814
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0216 0.0082
Mycobacterium ulcerans NAD-dependent deacetylase 0.0389 0.3921 0.6563
Brugia malayi glutaminase DH11.1 0.0569 0.5898 0.5898
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0088 0.0088
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0088 0.0088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0103 0.0354
Schistosoma mansoni kinase 0.0151 0.1312 0.1312

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.07 um PUBCHEM_BIOASSAY: Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3). (Class of assay: confirmatory) [Related pubchem assays: 1526, 1424, 1448 ] ChEMBL. No reference
EC50 (functional) > 29.9 um PUBCHEM_BIOASSAY: Fluorescence counterscreen assay for TRPML3 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1). (Class of assay: confirmatory) [Related pubchem assays: 1526, 1424, 1448 ] ChEMBL. No reference
IC50 (functional) 100 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2239 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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