Detailed information for compound 1391832

Basic information

Technical information
  • TDR Targets ID: 1391832
  • Name: 3,4-dimethyl-2-(morpholin-4-ylmethyl)-6-(1-ph enylethyl)phenol
  • MW: 325.445 | Formula: C21H27NO2
  • H donors: 1 H acceptors: 1 LogP: 4.01 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1c(C)cc(c(c1CN1CCOCC1)O)C(c1ccccc1)C
  • InChi: 1S/C21H27NO2/c1-15-13-19(17(3)18-7-5-4-6-8-18)21(23)20(16(15)2)14-22-9-11-24-12-10-22/h4-8,13,17,23H,9-12,14H2,1-3H3
  • InChiKey: DHODRICJAWWBRG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dimethyl-2-(morpholinomethyl)-6-(1-phenylethyl)phenol
  • MLS000064176
  • SMR000076114
  • A3385/0143609
  • 3,4-dimethyl-2-(4-morpholinylmethyl)-6-(1-phenylethyl)phenol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens mucolipin 3 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum expressed protein Get druggable targets OG5_129484 All targets in OG5_129484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus mucolipin 3 Get druggable targets OG5_129484 All targets in OG5_129484
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04994 mucolipin 3, putative Get druggable targets OG5_129484 All targets in OG5_129484
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis mucolipin 3 Get druggable targets OG5_129484 All targets in OG5_129484
Schistosoma mansoni mucolipin Get druggable targets OG5_129484 All targets in OG5_129484
Schistosoma mansoni mucolipin Get druggable targets OG5_129484 All targets in OG5_129484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) mucolipin 1 Get druggable targets OG5_129484 All targets in OG5_129484
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Coelomocyte uptake defective protein 5 Get druggable targets OG5_129484 All targets in OG5_129484
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni inositol monophosphatase 0.0045 0.0146 0.0146
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0051 0.0216 0.0317
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.078 0.078
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0147 0.1271 0.3074
Plasmodium vivax hypothetical protein, conserved 0.0242 0.2312 0.5896
Toxoplasma gondii NADPH-glutathione reductase 0.0051 0.0216 0.0552
Loa Loa (eye worm) hypothetical protein 0.0041 0.0103 0.0103
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0136 0.0048
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0389 0.3921 1
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0216 0.0082
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0655 0.0655
Entamoeba histolytica serine/threonine protein kinase, putative 0.0297 0.2913 0.285
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0088 0.0088
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0586 0.6083 0.6083
Schistosoma mansoni alpha-glucosidase 0.0169 0.1514 0.1514
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0389 0.3921 0.3867
Echinococcus multilocularis thioredoxin glutathione reductase 0.0147 0.1271 0.1271
Brugia malayi transcriptional regulator, Sir2 family protein 0.0242 0.2312 0.2312
Echinococcus multilocularis chromobox protein 1 0.0073 0.0452 0.0452
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0088 0.0088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0146 0.0011
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0051 0.0216 0.0082
Loa Loa (eye worm) glutaminase 2 0.0569 0.5898 0.5898
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0099 0.0099
Echinococcus multilocularis chromatin regulatory protein sir2 0.0943 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0297 0.2913 1
Echinococcus granulosus neuropeptide s receptor 0.0558 0.578 0.578
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Loa Loa (eye worm) hypothetical protein 0.0054 0.0245 0.0245
Giardia lamblia Transcriptional regulator, Sir2 family 0.0389 0.3921 0.3921
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0389 0.3921 0.3837
Brugia malayi chromobox protein homolog 3 0.0041 0.0103 0.0103
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0088 0.0088
Echinococcus granulosus Regulator of G protein signaling 20 0.0039 0.0088 0.0088
Brugia malayi Inositol-1 0.0045 0.0146 0.0146
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0136 0.0048
Toxoplasma gondii thioredoxin reductase 0.0147 0.1271 0.3241
Leishmania major sir2-family protein-like protein 0.0242 0.2312 0.2206
Echinococcus multilocularis Regulator of G protein signaling 20 0.0039 0.0088 0.0088
Trypanosoma cruzi trypanothione reductase, putative 0.0147 0.1271 0.1151
Mycobacterium ulcerans Sir2-like regulatory protein 0.0242 0.2312 0.3766
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0242 0.2312 0.5896
Brugia malayi jmjC domain containing protein 0.0102 0.078 0.078
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Echinococcus multilocularis citrate lyase subunit beta protein 0.0077 0.0502 0.0502
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0297 0.2913 0.2913
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0336 0.3338 0.8876
Plasmodium vivax glutathione reductase, putative 0.0147 0.1271 0.3241
Echinococcus granulosus expressed protein 0.0766 0.805 0.805
Schistosoma mansoni alpha-glucosidase 0.0169 0.1514 0.1514
Brugia malayi regulator of G-protein signaling rgs-7 0.0039 0.0088 0.0088
Brugia malayi TAR-binding protein 0.0065 0.0373 0.0373
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0088 0.0088
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0586 0.6083 0.6048
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0136 0.0136
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0373 0.3749 0.9551
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0263 0.0263
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0051 0.0216 0.0552
Onchocerca volvulus 0.0091 0.0655 0.2248
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0389 0.3921 0.3837
Echinococcus granulosus geminin 0.0205 0.1901 0.1901
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0072 0.0072
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0317 0.0317
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0072 0.0072
Brugia malayi Thioredoxin reductase 0.0147 0.1271 0.1271
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Mycobacterium ulcerans hypothetical protein 0.0077 0.0502 0.0618
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0389 0.3921 0.3867
Loa Loa (eye worm) hypothetical protein 0.0091 0.0655 0.0655
Trypanosoma brucei trypanothione reductase 0.0147 0.1271 0.1151
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0099 0.0099
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0146 0.0059
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0077 0.0502 0.1063
Onchocerca volvulus 0.0091 0.0655 0.2248
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0452 0.0367
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0216 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0146 0.0059
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.578 0.578
Brugia malayi Heterochromatin protein 1 0.0073 0.0452 0.0452
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0242 0.2312 0.2244
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0452 0.0452
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0263 0.0263
Schistosoma mansoni tyrosinase precursor 0.0091 0.0655 0.0655
Plasmodium vivax thioredoxin reductase, putative 0.0147 0.1271 0.3241
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0088 0.0088
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0051 0.0216 0.0082
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0146 0.0059
Echinococcus granulosus thioredoxin glutathione reductase 0.0147 0.1271 0.1271
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0655 0.0655
Plasmodium falciparum glutathione reductase 0.0147 0.1271 0.3241
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.1814 0.1814
Loa Loa (eye worm) hypothetical protein 0.0091 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.0205 0.1901 0.1901
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0136 0.0347
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0146 0.0146
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0943 1 1
Schistosoma mansoni chromobox protein 0.0073 0.0452 0.0452
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0051 0.0216 0.0552
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0103 0.0354
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0051 0.0216 0.0552
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0136 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0263 0.0263
Loa Loa (eye worm) tyrosinase 1 0.0091 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Giardia lamblia Sirtuin type 2 0.0242 0.2312 0.2312
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0655 0.0655
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0051 0.0216 0.0216
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0263 0.0263
Mycobacterium ulcerans NAD-dependent deacetylase 0.0389 0.3921 0.6563
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0136 0.0048
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0137 0.047
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0077 0.0502 0.0371
Mycobacterium ulcerans glutaminase 0.0569 0.5898 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0082
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0336 0.3338 0.8477
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0099 0.0099
Schistosoma mansoni chromatin regulatory protein sir2 0.0943 1 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0297 0.2913 0.2913
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0146 0.0011
Loa Loa (eye worm) hypothetical protein 0.0041 0.0108 0.0108
Loa Loa (eye worm) inositol-1 0.0045 0.0146 0.0146
Trypanosoma brucei polo-like protein kinase 0.0297 0.2913 0.2816
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0242 0.2312 0.2312
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0077 0.0502 0.0371
Brugia malayi Regulator of G protein signaling domain containing protein 0.0039 0.0088 0.0088
Schistosoma mansoni mucolipin 0.0072 0.0448 0.0448
Loa Loa (eye worm) mucolipin 1 0.0079 0.0521 0.0521
Schistosoma mansoni tyrosinase precursor 0.0091 0.0655 0.0655
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0103 0.0015
Schistosoma mansoni glutaminase 0.0569 0.5898 0.5898
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.578 0.578
Plasmodium falciparum thioredoxin reductase 0.0147 0.1271 0.3241
Mycobacterium tuberculosis Conserved protein 0.0077 0.0502 0.1063
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0336 0.3338 0.8477
Trichomonas vaginalis mercuric reductase, putative 0.0051 0.0216 0.0129
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0242 0.2312 0.2244
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0389 0.3921 1
Trichomonas vaginalis glutathione reductase, putative 0.0051 0.0216 0.0129
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0549 0.0549
Loa Loa (eye worm) transcriptional regulator 0.0943 1 1
Leishmania major silent information regulator 2, putative 0.0943 1 1
Echinococcus multilocularis axis inhibition protein axin 0.0039 0.0088 0.0088
Onchocerca volvulus 0.0032 0.0007 0.0023
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0051 0.0216 0.0122
Mycobacterium tuberculosis Probable reductase 0.0336 0.3338 0.8477
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0655 0.0655
Treponema pallidum NADH oxidase 0.0051 0.0216 0.5
Loa Loa (eye worm) glutaminase 0.0569 0.5898 0.5898
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0216
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0242 0.2312 0.2244
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0051 0.0216 0.0082
Plasmodium vivax NAD-dependent deacetylase, putative 0.0389 0.3921 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0088 0.0088
Schistosoma mansoni mucolipin 0.0079 0.0521 0.0521
Brugia malayi PXA domain containing protein 0.0039 0.0088 0.0088
Loa Loa (eye worm) RNA binding protein 0.0065 0.0373 0.0373
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0263 0.0263
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0077 0.0502 0.0371
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0077 0.0502 0.0417
Loa Loa (eye worm) glutathione reductase 0.0147 0.1271 0.1271
Schistosoma mansoni hypothetical protein 0.0041 0.0108 0.0108
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0136 0.0048
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1814 0.1814
Loa Loa (eye worm) transcriptional regulator 0.0242 0.2312 0.2312
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0136 0.0136
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0242 0.2312 0.2312
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.078 0.078
Schistosoma mansoni chromatin regulatory protein sir2 0.0242 0.2312 0.2312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0263 0.0263
Mycobacterium ulcerans hypothetical protein 0.0077 0.0502 0.0618
Brugia malayi regulator of G-protein signaling egl-10 0.0039 0.0088 0.0088
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0452 0.0367
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0943 1 1
Schistosoma mansoni hypothetical protein 0.0205 0.1901 0.1901
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0373 0.0373
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0099 0.0099
Toxoplasma gondii histone deacetylase SIR2-like 0.0242 0.2312 0.5896
Echinococcus multilocularis chromobox protein 1 0.0073 0.0452 0.0452
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0136 0.0048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0317 0.0317
Loa Loa (eye worm) PXA domain-containing protein 0.0039 0.0088 0.0088
Echinococcus multilocularis regulator of G protein signaling 0.0039 0.0088 0.0088
Brugia malayi transcriptional regulator, Sir2 family protein 0.0242 0.2312 0.2312
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0051 0.0216 0.0122
Loa Loa (eye worm) hypothetical protein 0.0344 0.3428 0.3428
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0068 0.0068
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0317 0.0317
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1269 0.1191
Giardia lamblia NADH oxidase lateral transfer candidate 0.0051 0.0216 0.0216
Echinococcus multilocularis expressed protein 0.0766 0.805 0.805
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0099 0.0099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Loa Loa (eye worm) thioredoxin reductase 0.0147 0.1271 0.1271
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0051 0.0216 0.0552
Brugia malayi serine/threonine-protein kinase plk-2 0.0297 0.2913 0.2913
Loa Loa (eye worm) transcriptional regulator 0.0242 0.2312 0.2312
Trypanosoma cruzi hypothetical protein, conserved 0.0669 0.699 0.6949
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0146 0.0146
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0586 0.6083 0.6048
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0137 0.0049
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0039 0.0088 0.0088
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0317 0.0317
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0108 0.0108
Echinococcus granulosus tar DNA binding protein 0.0065 0.0373 0.0373
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0242 0.2312 0.2312
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0216 0.0082
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Brugia malayi glutaminase DH11.1 0.0569 0.5898 0.5898
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0077 0.0502 0.0618
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0373 0.3749 1
Echinococcus granulosus chromobox protein 1 0.0073 0.0452 0.0452
Onchocerca volvulus 0.0091 0.0655 0.2248
Brugia malayi Coelomocyte uptake defective protein 5 0.0079 0.0521 0.0521
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0077 0.0502 0.0618
Brugia malayi hypothetical protein 0.0039 0.0088 0.0088
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0216
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0039 0.0088 0.0088
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0216
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0336 0.3338 0.8477
Brugia malayi hypothetical protein 0.0039 0.0088 0.0088
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0134 0.0134
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0586 0.6083 0.6083
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0088 0.0088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0088 0.0088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0051 0.0216 0.5
Echinococcus multilocularis regulator of G protein signaling 3 0.0039 0.0088 0.0088
Loa Loa (eye worm) RGS-3 protein 0.0039 0.0088 0.0088
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.1814 0.1814
Schistosoma mansoni kinase 0.0151 0.1312 0.1312
Mycobacterium tuberculosis Probable dehydrogenase 0.0336 0.3338 0.8477
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.578 0.578
Trypanosoma brucei hypothetical protein, conserved 0.0669 0.699 0.6949
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0146 0.0059
Leishmania major trypanothione reductase 0.0147 0.1271 0.1151
Echinococcus granulosus citrate lyase subunit beta protein 0.0077 0.0502 0.0502
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0051 0.0216 1
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0147 0.1266 0.3206
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0297 0.2913 0.2816
Schistosoma mansoni alpha glucosidase 0.0044 0.0136 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0943 1 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0389 0.3921 0.3837
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0943 1 1
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0134 0.0134
Schistosoma mansoni chromatin regulatory protein sir2 0.0943 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0263 0.0263
Schistosoma mansoni inositol monophosphatase 0.0045 0.0146 0.0146
Brugia malayi NAD-dependent deacetylase SIRT1 0.0586 0.6083 0.6083
Schistosoma mansoni chromatin regulatory protein sir2 0.0242 0.2312 0.2312
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0136 0.0048
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0122
Schistosoma mansoni chromobox protein 0.0073 0.0452 0.0452
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Brugia malayi ShTK domain containing protein 0.0091 0.0655 0.0655
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0072 0.0072
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0039 0.0088 0.0088
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0389 0.3921 0.3867
Mycobacterium tuberculosis Probable oxidoreductase 0.0373 0.3749 0.9551
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0077 0.0502 0.0618
Entamoeba histolytica hypothetical protein, conserved 0.0242 0.2312 0.2244
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0373 0.0373
Leishmania major hypothetical protein, conserved 0.0669 0.699 0.6949
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0943 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0586 0.6083 0.6083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0099 0.0099
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0373 0.0373
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1269 0.1191
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0373 0.0373
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0146 0.0011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0051 0.0216 0.0082
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0943 1 1
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0088 0.0088
Toxoplasma gondii histone deacetylase SIR2 0.0389 0.3921 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0091 0.0655 0.0655
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0373 0.3749 0.9551
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0072 0.0072
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0297 0.2913 0.2913
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0373 0.0373
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0389 0.3921 0.3867
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.1814 0.1814
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.1814 0.1814
Schistosoma mansoni axis inhibition protein axin 0.0039 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0586 0.6083 0.6083
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0146 0.0011
Plasmodium falciparum glutathione reductase 0.0051 0.0216 0.0552
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0039 0.0088 0.0088
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0137 0.0049
Brugia malayi RNA binding protein 0.0065 0.0373 0.0373
Schistosoma mansoni chromatin regulatory protein sir2 0.0389 0.3921 0.3921
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0586 0.6083 0.6048
Onchocerca volvulus 0.0091 0.0655 0.2248
Echinococcus granulosus mucolipin 3 0.0079 0.0521 0.0521
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Trypanosoma brucei SIR2-like protein 4, putative 0.0242 0.2312 0.2206
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0146 0.0373
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0068 0.0068
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0099 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.2913 0.2913
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0039 0.0088 0.0088
Loa Loa (eye worm) sirtuin 4 0.0242 0.2312 0.2312
Trypanosoma cruzi polo-like protein kinase, putative 0.0297 0.2913 0.2816
Echinococcus granulosus regulator of G protein signaling 3 0.0039 0.0088 0.0088
Schistosoma mansoni chromatin regulatory protein sir2 0.0943 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0039 0.0088 0.0088
Onchocerca volvulus 0.0114 0.0905 0.3106
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0072 0.0072
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0336 0.3338 0.8477
Echinococcus granulosus chromatin regulatory protein sir2 0.0943 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0051 0.0216 0.0082
Plasmodium falciparum thioredoxin reductase 0.0051 0.0216 0.0552
Echinococcus multilocularis mucolipin 3 0.0079 0.0521 0.0521
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0242 0.2312 0.2312
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Giardia lamblia Hypothetical protein 0.0943 1 1
Brugia malayi glutathione reductase 0.0147 0.1271 0.1271
Echinococcus granulosus chromobox protein 1 0.0073 0.0452 0.0452
Echinococcus multilocularis geminin 0.0205 0.1901 0.1901
Trichomonas vaginalis CAMK family protein kinase 0.0297 0.2913 0.285
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0136 0.0048
Schistosoma mansoni regulator of G protein signaling 0.0039 0.0088 0.0088
Trichomonas vaginalis glutaminase, putative 0.0569 0.5898 0.5861
Loa Loa (eye worm) hypothetical protein 0.0039 0.0088 0.0088
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0051 0.0216 0.0552
Echinococcus granulosus regulator of G protein signaling 7 0.0039 0.0088 0.0088
Echinococcus granulosus axis inhibition protein axin 0.0039 0.0088 0.0088
Brugia malayi PXA domain containing protein 0.0039 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0103 0.0015
Trypanosoma cruzi hypothetical protein, conserved 0.0669 0.699 0.6949
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0051 0.0216 0.0082
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0586 0.6083 0.6083
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0389 0.3921 0.3837
Brugia malayi A-kinase anchor protein 10, precursor 0.0039 0.0088 0.0088
Giardia lamblia Kinase, PLK 0.0297 0.2913 0.2913
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0943 1 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0297 0.2913 0.2816
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0655 0.0655
Brugia malayi Common central domain of tyrosinase family protein 0.0091 0.0655 0.0655
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0365 0.0365
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0586 0.6083 0.6048
Schistosoma mansoni z-protein (S1r protein) 0.0039 0.0088 0.0088
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0943 1 1
Brugia malayi jmjC domain containing protein 0.0038 0.0072 0.0072
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0051 0.0216 0.0082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0263 0.0263
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0136 0.0136

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.07 um PUBCHEM_BIOASSAY: Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3). (Class of assay: confirmatory) [Related pubchem assays: 1526, 1424, 1448 ] ChEMBL. No reference
EC50 (functional) > 29.9 um PUBCHEM_BIOASSAY: Fluorescence counterscreen assay for TRPML3 agonists: dose response cell-based high-throughput screening assay to identify agonists of the transient receptor potential channel N1 (TRPN1). (Class of assay: confirmatory) [Related pubchem assays: 1526, 1424, 1448 ] ChEMBL. No reference
IC50 (functional) 100 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2239 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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