Detailed information for compound 1394751

Basic information

Technical information
  • TDR Targets ID: 1394751
  • Name: 4-[methyl-(4-methylphenyl)sulfonylamino]-N-(2 -phenylethyl)benzamide
  • MW: 408.513 | Formula: C23H24N2O3S
  • H donors: 1 H acceptors: 3 LogP: 4.23 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)N(c1ccc(cc1)C(=O)NCCc1ccccc1)C
  • InChi: 1S/C23H24N2O3S/c1-18-8-14-22(15-9-18)29(27,28)25(2)21-12-10-20(11-13-21)23(26)24-17-16-19-6-4-3-5-7-19/h3-15H,16-17H2,1-2H3,(H,24,26)
  • InChiKey: KVXIKLGTJAXYIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[methyl-(4-methylphenyl)sulfonyl-amino]-N-(2-phenylethyl)benzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.016 0.1115
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.025 0.0392
Brugia malayi P21-Rho-binding domain containing protein 0.0151 0.0753 0.0753
Brugia malayi Protein kinase domain containing protein 0.004 0.0121 0.0121
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0185 0.1464
Schistosoma mansoni hypothetical protein 0.0041 0.0126 0.1417
Brugia malayi Kinase associated domain 1 family protein 0.0034 0.0088 0.0088
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0157 0.0786 0.086
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0144 0.071 0.071
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0381 0.4286
Trichomonas vaginalis STE family protein kinase 0.0157 0.0786 1
Echinococcus multilocularis calcium activated potassium channel 0.004 0.0121 0.0132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0139 0.0152
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0121 0.1356
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0121 0.1356
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.025 0.2394
Giardia lamblia Kinase, CMGC CDK 0.0144 0.071 0.8791
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0232 0.0232
Brugia malayi Protein kinase domain containing protein 0.0144 0.071 0.071
Echinococcus granulosus mitogen activated protein kinase 0.0063 0.025 0.0274
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0144 0.071 0.0777
Trichomonas vaginalis STE family protein kinase 0.0157 0.0786 1
Plasmodium falciparum glycogen synthase kinase 3 0.006 0.0232 0.1295
Giardia lamblia Kinase, CMGC MAPK 0.0063 0.025 0.1438
Giardia lamblia Kinase, CMGC GSK 0.006 0.0232 0.1138
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0151 0.0753 0.0824
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.025 0.2815
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0181 0.1405
Entamoeba histolytica hypothetical protein 0.0151 0.0753 0.9491
Entamoeba histolytica p21-activated kinase 0.0157 0.0786 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0063 0.025 0.0392
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0235 0.0235
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0157 0.0786 0.086
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0086 0.0381 0.0417
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0185 0.0202
Entamoeba histolytica cell division protein kinase 2, putative 0.0144 0.071 0.8831
Brugia malayi intracellular kinase 0.006 0.0232 0.0232
Brugia malayi Protein kinase domain 0.0157 0.0786 0.0786
Loa Loa (eye worm) hypothetical protein 0.0051 0.0185 0.0185
Entamoeba histolytica protein kinase, putative 0.0157 0.0786 1
Echinococcus multilocularis serine:threonine protein kinase 0.0051 0.0185 0.0202
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0232 0.143
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0861 0.0943
Loa Loa (eye worm) hypothetical protein 0.0151 0.0753 0.0753
Echinococcus granulosus PAK box P21 Rho binding 0.0151 0.0753 0.0824
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.025 0.2394
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0144 0.071 1
Schistosoma mansoni chromobox protein 0.0084 0.0371 0.4173
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.071 0.8926
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0139 0.1564
Brugia malayi P21-Rho-binding domain containing protein 0.0151 0.0753 0.0753
Plasmodium vivax protein kinase Crk2 0.0144 0.071 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.0677 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.0151 0.0753 0.9533
Entamoeba histolytica protein kinase, putative 0.0157 0.0786 1
Echinococcus multilocularis protein kinase shaggy 0.006 0.0232 0.0253
Trypanosoma brucei cdc2-related kinase 3 0.0144 0.071 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0063 0.025 0.0392
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0889 0.0889
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0121 0.0551
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0181 0.1405
Echinococcus multilocularis cyclin dependent kinase 1 0.0144 0.071 0.0777
Loa Loa (eye worm) CMGC/GSK protein kinase 0.006 0.0232 0.0232
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0181 0.6067
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0232 0.2128
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0889 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0371 0.411
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5474 0.599
Echinococcus granulosus chromobox protein 1 0.0084 0.0371 0.0406
Schistosoma mansoni hypothetical protein 0.0043 0.0139 0.1564
Loa Loa (eye worm) hypothetical protein 0.0034 0.0088 0.0088
Schistosoma mansoni protein kinase 0.0157 0.0786 0.8835
Echinococcus granulosus calcium activated potassium channel 0.004 0.0121 0.0132
Echinococcus granulosus cyclin dependent kinase 5 0.0144 0.071 0.0777
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0185 0.1464
Schistosoma mansoni hypothetical protein 0.0151 0.0753 0.8465
Echinococcus granulosus protein kinase shaggy 0.006 0.0232 0.0253
Schistosoma mansoni hypothetical protein 0.0034 0.0088 0.0986
Trichomonas vaginalis STE family protein kinase 0.0157 0.0786 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0144 0.071 1
Echinococcus multilocularis mitogen activated protein kinase 0.0063 0.025 0.0274
Trypanosoma cruzi cdc2-related kinase 1 0.0144 0.071 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0063 0.025 0.0274
Entamoeba histolytica protein kinase domain containing protein 0.006 0.0232 0.143
Loa Loa (eye worm) hypothetical protein 0.0047 0.016 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.0753 0.8465
Echinococcus multilocularis PAK box P21 Rho binding 0.0151 0.0753 0.0824
Echinococcus multilocularis cyclin dependent kinase 0.0144 0.071 0.0777
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.071 0.7985
Echinococcus granulosus chromobox protein 1 0.0084 0.0371 0.0406
Echinococcus granulosus serine:threonine protein kinase 0.0051 0.0185 0.0202
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0157 0.0786 0.086
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.025 0.2394
Echinococcus multilocularis cyclin dependent kinase 5 0.0144 0.071 0.0777
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0889 0.0973
Trypanosoma cruzi cdc2-related kinase 1 0.0144 0.071 1
Entamoeba histolytica protein kinase, putative 0.0157 0.0786 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0144 0.071 0.8831
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0235 0.0235
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0157 0.0786 0.086
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.004 0.0121 0.0121
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.006 0.0232 0.0253
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0063 0.025 0.0392
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0144 0.071 0.071
Schistosoma mansoni chromobox protein 0.0084 0.0371 0.4173
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0151 0.0753 0.0824
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0371 0.411
Schistosoma mansoni protein kinase 0.0151 0.0753 0.8465
Echinococcus multilocularis chromobox protein 1 0.0084 0.0371 0.0406
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.071 0.8926
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0051 0.0185 0.0185
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0144 0.071 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0063 0.025 0.025
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.006 0.0232 0.2604
Trypanosoma brucei cdc2-related kinase 1 0.0144 0.071 1
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0086 0.0381 0.0417
Entamoeba histolytica hypothetical protein 0.0151 0.0753 0.9491
Echinococcus granulosus cyclin dependent kinase 1 0.0144 0.071 0.0777
Schistosoma mansoni hypothetical protein 0.0151 0.0753 0.8465
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0157 0.0786 0.086
Trypanosoma cruzi cdc2-related kinase 3 0.0144 0.071 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0063 0.025 0.0392
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0139 0.0152
Brugia malayi chromobox protein homolog 3 0.0047 0.016 0.016
Brugia malayi Heterochromatin protein 1 0.0084 0.0371 0.0371
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.016 0.1115
Giardia lamblia Kinase, CMGC CDK 0.0144 0.071 0.8791
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.025 0.2394
Echinococcus multilocularis cyclin dependent kinase 1 0.0144 0.071 0.0777
Trichomonas vaginalis STE family protein kinase 0.0157 0.0786 1
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0086 0.0381 0.0417
Trichomonas vaginalis STE family protein kinase 0.0157 0.0786 1
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0151 0.0753 0.0824
Trichomonas vaginalis CMGC family protein kinase 0.0144 0.071 0.8926
Loa Loa (eye worm) hypothetical protein 0.006 0.0235 0.0235
Plasmodium vivax glycogen synthase kinase 3, putative 0.006 0.0232 0.089
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0121 0.1356
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.025 0.0392
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0151 0.0753 0.8465
Echinococcus granulosus cyclin dependent kinase 0.0144 0.071 0.0777
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0126 0.0126
Schistosoma mansoni serine/threonine kinase 0.004 0.0121 0.1356
Loa Loa (eye worm) hypothetical protein 0.0041 0.0126 0.0126
Brugia malayi MAP kinase sur-1 0.0063 0.025 0.025
Schistosoma mansoni protein kinase 0.0157 0.0786 0.8835
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.1622 0.9139 1
Entamoeba histolytica protein kinase, putative 0.0157 0.0786 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0144 0.071 0.071
Entamoeba histolytica protein kinase, putative 0.006 0.0232 0.143
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.1773 1 1
Plasmodium falciparum protein kinase 5 0.0144 0.071 1
Loa Loa (eye worm) acetyltransferase 0.0175 0.0889 0.0889
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0232 0.2128
Onchocerca volvulus 0.006 0.0232 1
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.1622 0.9139 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0185 0.1464
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.016 0.033
Echinococcus multilocularis mitogen activated protein kinase 3 0.0063 0.025 0.0274
Echinococcus multilocularis PAK box P21 Rho binding 0.0157 0.0786 0.086
Loa Loa (eye worm) hypothetical protein 0.0037 0.0102 0.0102
Trypanosoma brucei protein kinase, putative 0.0063 0.025 0.0392
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.006 0.0232 0.089
Schistosoma mansoni tyrosine kinase 0.0151 0.0753 0.8465
Echinococcus multilocularis chromobox protein 1 0.0084 0.0371 0.0406
Echinococcus granulosus glycogen synthase kinase 3 beta 0.006 0.0232 0.0253
Brugia malayi WH1 domain containing protein 0.0151 0.0753 0.0753
Giardia lamblia Kinase, STE STE20 0.0157 0.0786 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0235 0.0235
Echinococcus multilocularis hypothetical protein 0.0034 0.0088 0.0096
Trypanosoma cruzi cdc2-related kinase 3 0.0144 0.071 1
Schistosoma mansoni hypothetical protein 0.0034 0.0088 0.0986
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0151 0.0753 0.0753
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0371 0.0371
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0063 0.025 0.1247
Schistosoma mansoni protein kinase 0.0157 0.0786 0.8835
Echinococcus granulosus serine:threonine protein kinase 0.0051 0.0185 0.0202
Brugia malayi Protein kinase domain containing protein 0.0051 0.0185 0.0185
Giardia lamblia Kinase, CMGC GSK 0.006 0.0232 0.1138
Schistosoma mansoni serine/threonine protein kinase 0.0086 0.0381 0.4286
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0086 0.0381 0.0417
Brugia malayi cell division control protein 2 homolog 0.0144 0.071 0.071
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0063 0.025 0.0392
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.071 0.7985
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.016 0.4489
Schistosoma mansoni hypothetical protein 0.0151 0.0753 0.8465
Brugia malayi hypothetical protein 0.0043 0.0139 0.0139
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0157 0.0786 0.086
Echinococcus multilocularis serine:threonine protein kinase 0.0051 0.0185 0.0202

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3489 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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