TDR Targets

Basic information

Technical information

TDR Targets ID: 1400983
Name: N-(2,4-dimethoxyphenyl)-N'-(pyridin-2-ylmethy l)bicyclo[2.2.1]hept-2-ene-5,6-dicarboxamide
MW: 407.462 | Formula: C23H25N3O4
H donors: 2 H acceptors: 3 LogP: 1.81 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(OC)ccc1NC(=O)C1C2C=CC(C1C(=O)NCc1ccccn1)C2
InChi: 1S/C23H25N3O4/c1-29-17-8-9-18(19(12-17)30-2)26-23(28)21-15-7-6-14(11-15)20(21)22(27)25-13-16-5-3-4-10-24-16/h3-10,12,14-15,20-21H,11,13H2,1-2H3,(H,25,27)(H,26,28)
InChiKey: LEZRGZQBGYDUTI-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-(2,4-dimethoxyphenyl)-N'-(2-pyridylmethyl)bicyclo[2.2.1]hept-2-ene-5,6-dicarboxamide
Oprea1_460712
Bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid 2-[(2,4-dimethoxy-phenyl)-amide] 3-[(pyridin-2-ylmethyl)-amide]
ASN 03326403
MLS000120911
SMR000118315

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0026	0.0091	0.318
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0146	0.0623
Schistosoma mansoni	threonyl-tRNA synthetase	0.001	0.0003	0.0012
Loa Loa (eye worm)	63kd antigen	0.0015	0.0029	0.012
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0135	0.0677	0.8704
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0146	0.1845
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0282	0.1209
Schistosoma mansoni	amine GPCR	0.001	0.0001	0.0006
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.001	0.0001	0.0006
Toxoplasma gondii	glycyl-tRNA synthetase	0.0025	0.0083	0.0121
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0093	0.0451	0.3676
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0012	0.0015	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0085	0.036
Brugia malayi	hypothetical protein	0.0043	0.0181	0.0781
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0048	0.0045
Schistosoma mansoni	amine GPCR	0.001	0.0001	0.0006
Plasmodium vivax	replication protein A1, large subunit, putative	0.0012	0.0015	0.0012
Trypanosoma brucei	histidyl-tRNA synthetase	0.0015	0.003	0.0346
Onchocerca volvulus	Putative transporter	0.0062	0.0282	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0013	0.0018	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0013	0.0018	0.0268
Echinococcus multilocularis	prolyl tRNA synthetase, mitochondrial	0.001	0.0003	0.0006
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0048	0.0201
Brugia malayi	major facilitator superfamily protein	0.0062	0.0282	0.1219
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0062	0.0282	0.2253
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0146	0.0623
Plasmodium vivax	metacaspase 1, putative	0.0018	0.0049	0.0046
Echinococcus multilocularis	Seryl tRNA Synthetase	0.001	0.0003	0.0006
Echinococcus granulosus	solute carrier family 22	0.0062	0.0282	0.1214
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0456	0.1969
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0684	0.879
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0098	0.0478	0.6134
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0282	0.1219
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0135	0.0678	0.1016
Giardia lamblia	Hexose transporter	0.0062	0.0282	0.4257
Loa Loa (eye worm)	glycyl-tRNA synthetase	0.0025	0.0083	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.001	0.0001	0.0006
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0048	0.0584
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0085	0.1059
Echinococcus granulosus	solute carrier family 22	0.0062	0.0282	0.1214
Echinococcus granulosus	solute carrier family 22	0.0062	0.0282	0.1214
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.01	0.0426
Trypanosoma cruzi	replication Factor A 28 kDa subunit, putative	0.0012	0.0015	0.0154
Brugia malayi	intermediate filament protein	0.0026	0.0091	0.0392
Schistosoma mansoni	amine GPCR	0.001	0.0001	0.0006
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0148	0.0145
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0062	0.0282	0.2253
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0098	0.0478	0.2054
Trichomonas vaginalis	glycyl-tRNA synthetase, putative	0.0015	0.003	0.0116
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0048	0.0201
Entamoeba histolytica	protein kinase, putative	0.0135	0.0677	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0439	0.2317	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0001	0.0006
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0031	0.0119	0.1774
Brugia malayi	Dopamine receptor protein 2	0.001	0.0001	0.0006
Onchocerca volvulus		0.0062	0.0282	1
Onchocerca volvulus		0.0062	0.0282	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0061	0.0281	0.3592
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0083	0.0398	0.3229
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0144	0.0727	0.3139
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0136	0.0684	0.879
Trypanosoma cruzi	Replication factor A protein 1	0.0012	0.0015	0.0154
Giardia lamblia	Prolyl-tRNA synthetase	0.0132	0.066	1
Loa Loa (eye worm)	seryl-tRNA synthetase	0.001	0.0003	0.0006
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0061	0.0281	0.3592
Echinococcus granulosus	6 phosphofructokinase	0.0117	0.0578	0.249
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0025	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0059
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0146	0.1103
Brugia malayi	hypothetical protein	0.0062	0.0282	0.1219
Echinococcus granulosus	Threonyl tRNA synthetase C	0.0025	0.0083	0.0351
Entamoeba histolytica	phosphofructokinase, putative	0.0117	0.0578	0.8529
Trypanosoma brucei	Metacaspase-4	0.0018	0.0049	0.0596
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0154	0.0778	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.001	0.0001	0.0006
Trichomonas vaginalis	glucose transporter, putative	0.0062	0.0282	0.1209
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0029	0.0126
Schistosoma mansoni	replication factor A 1 rfa1	0.0012	0.0015	0.0063
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0091	0.0392
Trypanosoma cruzi	histidyl-tRNA synthetase	0.0015	0.003	0.0346
Trypanosoma cruzi	hexose transporter	0.0136	0.0684	0.879
Onchocerca volvulus		0.0062	0.0282	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0146	0.1103
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0094	0.0456	0.1965
Brugia malayi	G-protein coupled receptor	0.001	0.0001	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0136	0.0684	0.2943
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0015	0.003	0.0346
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0282	0.1209
Leishmania major	replication Factor A 28 kDa subunit, putative	0.0012	0.0015	0.0154
Brugia malayi	Sars1 protein	0.001	0.0003	0.0012
Schistosoma mansoni	biogenic amine (5HT) receptor	0.001	0.0001	0.0006
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0025	0.0083	0.1033
Toxoplasma gondii	YbaK/proline-tRNA ligase associated domain-containing protein	0.0022	0.0067	0.0097
Toxoplasma gondii	aspartate-tRNA ligase	0.0015	0.0029	0.004
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0094	0.0456	0.197
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0282	0.1209
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0119	0.0117
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0061	0.0281	0.1208
Giardia lamblia	Lysyl-tRNA synthetase	0.0098	0.0478	0.7233
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0478	0.2058
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0062	0.0282	0.4863
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0135	0.0677	0.2918
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0119	0.0504
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Trypanosoma cruzi	hexose transporter, putative	0.0136	0.0684	0.879
Leishmania major	replication factor A, 51kDa subunit, putative	0.0012	0.0015	0.0154
Echinococcus granulosus	tumor protein p63	0.0408	0.215	0.9278
Echinococcus granulosus	asparaginyl tRNA synthetase cytoplasmic	0.0015	0.0029	0.012
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0267	0.1149
Schistosoma mansoni	seryl-tRNA synthetase	0.001	0.0003	0.0012
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0062	0.0282	0.361
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0132	0.066	0.2848
Leishmania major	lysyl-tRNA synthetase, putative	0.0098	0.0478	0.6134
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0136	0.0684	0.879
Schistosoma mansoni	opsin-like receptor	0.001	0.0001	0.0006
Brugia malayi	Cell death protein 3 precursor	0.0061	0.028	0.121
Plasmodium vivax	hypothetical protein, conserved	0.0018	0.0049	0.0046
Trichomonas vaginalis	sugar transport protein, putative	0.0062	0.0282	0.1209
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0049	0.02
Trypanosoma cruzi	glucose transporter, putative	0.0062	0.0282	0.361
Schistosoma mansoni	histidyl-tRNA synthetase	0.0015	0.003	0.0127
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0093	0.0451	0.3676
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0146	0.0623
Onchocerca volvulus		0.0062	0.0282	1
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0012	0.0015	0.0154
Plasmodium falciparum	nucleic acid binding protein, putative	0.0012	0.0015	0.0012
Toxoplasma gondii	histidyl-tRNA synthetase (HisRS), putative	0.0015	0.003	0.004
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Schistosoma mansoni	ap endonuclease	0.0018	0.0048	0.0207
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0282	0.1214
Wolbachia endosymbiont of Brugia malayi	prolyl-tRNA synthetase	0.0025	0.0083	0.286
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.0018	0.0023
Echinococcus granulosus	histone acetyltransferase KAT2B	0.014	0.0706	0.3041
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0439	0.2317	1
Plasmodium falciparum	aspartate--tRNA ligase	0.0015	0.0029	0.0026
Schistosoma mansoni	opsin-like receptor	0.001	0.0001	0.0006
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0267	0.1154
Trypanosoma cruzi	glycyl-tRNA synthetase, putative	0.0015	0.003	0.0346
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0268	0.1158
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0088	0.0375
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.001	0.0001	0.0006
Schistosoma mansoni	myosin xvIII	0.001	0.0001	0.0006
Leishmania major	aspartyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Trypanosoma brucei	metacaspase MCA3	0.0018	0.0049	0.0596
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0135	0.0678	0.0675
Wolbachia endosymbiont of Brugia malayi	histidyl-tRNA synthetase	0.0015	0.003	0.0958
Plasmodium falciparum	asparagine--tRNA ligase	0.0015	0.0029	0.0026
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0178	0.0758
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0135	0.0678	0.0675
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0018	0.0199
Leishmania major	hypothetical protein, conserved	0.0062	0.0282	0.361
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0146	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0049	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0132	0.066	0.2844
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0146	0.1103
Schistosoma mansoni	hypothetical protein	0.0169	0.0859	0.3707
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0684	0.879
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0146	0.1103
Schistosoma mansoni	6-phosphofructokinase	0.0117	0.0578	0.2494
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0267	0.3416
Onchocerca volvulus		0.0062	0.0282	1
Echinococcus multilocularis	geminin	0.0169	0.0859	0.3703
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0135	0.0677	0.2918
Trypanosoma brucei	metacaspase MCA2	0.0018	0.0049	0.0596
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0061	0.0281	0.3592
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0439	0.2317	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0061	0.0281	0.3592
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0684	0.879
Trichomonas vaginalis	sugar transporter, putative	0.0136	0.0684	0.2943
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0031	0.0119	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0132	0.066	0.2844
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0013	0.0018	0.0199
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0018	0.0049	0.0206
Plasmodium falciparum	glycine--tRNA ligase	0.0015	0.003	0.0027
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0029	0.0126
Brugia malayi	sulfakinin receptor protein	0.001	0.0001	0.0006
Echinococcus multilocularis	6 phosphofructokinase	0.0117	0.0578	0.249
Trypanosoma brucei	aspartyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0025	0.0083	0.1033
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0091	0.0386
Echinococcus granulosus	mitogen activated protein kinase	0.0061	0.0281	0.1208
Brugia malayi	Serotonin receptor	0.001	0.0001	0.0006
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.0018	0.0023
Plasmodium vivax	proline--tRNA ligase, putative	0.0154	0.0778	0.0775
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trypanosoma cruzi	hexose transporter, putative	0.0074	0.0351	0.4494
Schistosoma mansoni	hypothetical protein	0.001	0.0001	0.0006
Onchocerca volvulus		0.006	0.0272	0.9615
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0018	0.0071
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0136	0.0684	0.879
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0013	0.0018	0.0268
Plasmodium falciparum	protein kinase 7	0.1241	0.6641	0.664
Plasmodium falciparum	hexose transporter	0.0439	0.2317	0.2315
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0031	0.0119	0.2027
Trypanosoma cruzi	hexose transporter, putative	0.0136	0.0684	0.879
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0136	0.0684	0.879
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.001	0.0038
Brugia malayi	RE15519p	0.001	0.0001	0.0006
Schistosoma mansoni	sugar transporter	0.0062	0.0282	0.1219
Echinococcus granulosus	mitogen activated protein kinase 3	0.0061	0.0281	0.1208
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0146	0.1103
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0146	0.0623
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0067	0.0832
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0684	0.879
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Schistosoma mansoni	biogenic amine (5HT) receptor	0.001	0.0001	0.0006
Onchocerca volvulus		0.0062	0.0282	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0098	0.0478	0.2058
Treponema pallidum	aspartyl-tRNA synthetase	0.0015	0.0029	0.046
Giardia lamblia	Threonyl-tRNA synthetase	0.0025	0.0083	0.1217
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0135	0.0677	0.2918
Entamoeba histolytica	threonyl-tRNA synthetase, putative	0.0025	0.0083	0.1186
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Onchocerca volvulus		0.0062	0.0282	1
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0684	0.879
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0083	0.0398	0.5947
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Schistosoma mansoni	lamin	0.0026	0.0091	0.0391
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0117	0.0578	0.7424
Trypanosoma brucei	Aminoacyl-tRNA editing domain containing protein, putative	0.0022	0.0067	0.0832
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0018	0.0067
Toxoplasma gondii	phosphofructokinase PFKII	0.0031	0.0119	0.0176
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0085	0.1059
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0146	0.0618
Loa Loa (eye worm)	replication factor A 73 kDa subunit	0.0012	0.0015	0.0058
Plasmodium vivax	lysine--tRNA ligase, putative	0.0098	0.0478	0.0475
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0146	0.2486
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0132	0.066	0.2844
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0135	0.0677	0.2918
Echinococcus multilocularis	caspase	0.0018	0.0049	0.0206
Brugia malayi	glutathione reductase	0.0037	0.0148	0.0637
Loa Loa (eye worm)	histidyl-tRNA synthetase	0.0015	0.003	0.0122
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Echinococcus multilocularis	musashi	0.0026	0.0091	0.0386
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0048	0.0689
Trypanosoma brucei	metacaspase 5, putative	0.0018	0.0049	0.0596
Schistosoma mansoni	hypothetical protein	0.001	0.0001	0.0006
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.1203	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0117	0.0578	0.2485
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0018	0.0073
Schistosoma mansoni	protein kinase	0.0135	0.0677	0.2922
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0146	0.0623
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0282	0.1214
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Echinococcus multilocularis	General substrate transporter	0.0377	0.1984	0.8562
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0049	0.02
Brugia malayi	Dopamine receptor protein 1	0.001	0.0001	0.0006
Schistosoma mansoni	sugar transporter	0.0062	0.0282	0.1219
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0135	0.0677	0.2918
Toxoplasma gondii	OB-fold nucleic acid binding domain-containing protein	0.0012	0.0015	0.0018
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0029	0.0126
Giardia lamblia	Kinase, CMGC MAPK	0.0061	0.0281	0.4236
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0132	0.066	0.2848
Toxoplasma gondii	sugar transporter ST1	0.0062	0.0282	0.0421
Schistosoma mansoni	adenoreceptor	0.001	0.0001	0.0006
Echinococcus granulosus	histidyl tRNA synthetase	0.0015	0.003	0.0122
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0047	0.02	0.3437
Loa Loa (eye worm)	hypothetical protein	0.006	0.0272	0.1167
Mycobacterium ulcerans	lipase LipD	0.0036	0.0146	0.2486
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0029	0.0126
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0012	0.0015	0.0063
Schistosoma mansoni	amine GPCR	0.001	0.0001	0.0006
Leishmania major	glucose transporter, lmgt2	0.0136	0.0684	0.879
Trichomonas vaginalis	glucose transporter, putative	0.0136	0.0684	0.2943
Echinococcus granulosus	glycyl tRNA synthetase	0.0025	0.0083	0.0351
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0013	0.0018	0.0199
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0117	0.0578	1
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0146	0.0623
Onchocerca volvulus		0.0036	0.0146	0.5136
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0012	0.0015	0.0052
Giardia lamblia	Glycyl-tRNA synthetase	0.0025	0.0083	0.1217
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0146	0.1845
Schistosoma mansoni	sugar transporter	0.0062	0.0282	0.1219
Echinococcus multilocularis	Threonyl tRNA synthetase, C	0.0025	0.0083	0.0351
Brugia malayi	hypothetical protein	0.0039	0.0158	0.068
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0132	0.066	0.2848
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0135	0.0677	0.2918
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0029	0.0126
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0119	0.0504
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0684	0.879
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0159	0.232
Echinococcus granulosus	lamin	0.0026	0.0091	0.0386
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0015	0.0029	0.012
Onchocerca volvulus		0.0062	0.0282	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0062	0.0282	0.1214
Schistosoma mansoni	neuropeptide receptor	0.001	0.0001	0.0006
Trypanosoma brucei	sugar transporter, putative	0.0062	0.0282	0.361
Schistosoma mansoni	hypothetical protein	0.0169	0.0859	0.3707
Plasmodium falciparum	metacaspase 1	0.0018	0.0049	0.0046
Brugia malayi	Melatonin receptor type 1A	0.001	0.0001	0.0006
Leishmania major	aspartyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Entamoeba histolytica	hypothetical protein	0.0039	0.0158	0.2295
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0119	0.0504
Schistosoma mansoni	cpg binding protein	0.0029	0.0109	0.0468
Schistosoma mansoni	histamine h1 receptor	0.001	0.0001	0.0006
Leishmania major	protein kinase, putative	0.0135	0.0677	0.8704
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0013	0.0018	0.0199
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0013	0.0018	0.0015
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0022	0.0067	0.0832
Echinococcus granulosus	apoptotic protease activating factor 1	0.0043	0.0181	0.0776
Leishmania major	histidyl-tRNA synthetase, putative	0.0015	0.003	0.0346
Loa Loa (eye worm)	sugar transporter	0.0439	0.2317	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trypanosoma cruzi	trypanothione reductase, putative	0.0013	0.0018	0.0199
Loa Loa (eye worm)	aspartyl-tRNA synthetase	0.0015	0.0029	0.012
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0267	0.4602
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0146	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Trichomonas vaginalis	interferon-induced, double-stranded RNA-activated protein kinase, putative	0.0015	0.003	0.0116
Toxoplasma gondii	facilitative glucose transporter GT1	0.0439	0.2317	0.3486
Wolbachia endosymbiont of Brugia malayi	threonyl-tRNA synthetase	0.0025	0.0083	0.286
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0148	0.1118
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0018	0.0199
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0061	0.0281	0.0419
Schistosoma mansoni	neuropeptide receptor	0.001	0.0001	0.0006
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0267	0.2127
Plasmodium falciparum	lysine--tRNA ligase	0.0098	0.0478	0.0475
Schistosoma mansoni	ap endonuclease	0.0018	0.0048	0.0207
Onchocerca volvulus		0.0062	0.0282	1
Brugia malayi	Sugar transporter family protein	0.0062	0.0282	0.1219
Plasmodium falciparum	glutathione reductase	0.0013	0.0018	0.0015
Brugia malayi	probable proline-trna synthetase - fission yeast, putative	0.0025	0.0083	0.0357
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.001	0.0001	0.0006
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.001	0.0038
Entamoeba histolytica	hypothetical protein	0.0098	0.0478	0.7048
Brugia malayi	Sugar transporter family protein	0.0062	0.0282	0.1219
Brugia malayi	major facilitator superfamily protein	0.0062	0.0282	0.1219
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0135	0.0677	0.2918
Schistosoma mansoni	growth hormone secretagogue receptor	0.001	0.0001	0.0006
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0048	0.0787
Schistosoma mansoni	hypothetical protein	0.0011	0.001	0.0044
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0135	0.0677	0.2918
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.015	0.0643
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0062	0.0282	0.1214
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0178	0.0264
Trichomonas vaginalis	sugar transporter, putative	0.0136	0.0684	0.2943
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0049	0.02
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0154	0.0778	1
Schistosoma mansoni	protein kinase	0.0135	0.0677	0.2922
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.0281	0.1203
Schistosoma mansoni	caspase-7 (C14 family)	0.0018	0.0049	0.0211
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0049	0.02
Schistosoma mansoni	caspase-3 (C14 family)	0.0018	0.0049	0.0211
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0018	0.0049	0.007
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0031	0.0119	0.0176
Plasmodium falciparum	histidine--tRNA ligase, putative	0.0015	0.003	0.0027
Echinococcus granulosus	cpg binding protein	0.0029	0.0109	0.0463
Schistosoma mansoni	serine/threonine protein kinase	0.0061	0.0281	0.1213
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0527	0.2268
Schistosoma mansoni	glucose transport protein	0.0439	0.2317	1
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Loa Loa (eye worm)	Sars1 protein	0.001	0.0003	0.0006
Trichomonas vaginalis	myo-inositol transporter, putative	0.0062	0.0282	0.1209
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0085	0.0082
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0018	0.0199
Entamoeba histolytica	phosphofructokinase, putative	0.0117	0.0578	0.8529
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0154	0.0778	1
Schistosoma mansoni	cpg binding protein	0.0028	0.01	0.0431
Echinococcus granulosus	caspase 2	0.0061	0.028	0.1205
Onchocerca volvulus	Putative replication factor A 73 kDa subunit	0.0012	0.0015	0.0475
Chlamydia trachomatis	proline--tRNA ligase	0.0047	0.02	0.416
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0117	0.0578	0.7424
Brugia malayi	follicle stimulating hormone receptor	0.001	0.0001	0.0006
Leishmania major	hypothetical protein, conserved	0.0025	0.0085	0.1059
Giardia lamblia	Hypothetical protein	0.0012	0.0015	0.0182
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Schistosoma mansoni	serine/threonine protein kinase	0.0135	0.0677	0.2922
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0159	0.2381
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0018	0.0199
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0018	0.0049	0.0212
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.001	0.0001	0.0006
Treponema pallidum	threonyl-tRNA synthetase	0.0025	0.0083	0.1391
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0015	0.0059
Loa Loa (eye worm)	sugar transporter	0.0062	0.0282	0.1214
Schistosoma mansoni	neuropeptide F-like receptor	0.001	0.0001	0.0006
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0178	0.0758
Schistosoma mansoni	biogenic amine receptor	0.001	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Loa Loa (eye worm)	6-phosphofructokinase	0.0117	0.0578	0.249
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0018	0.0199
Schistosoma mansoni	hypothetical protein	0.0439	0.2317	1
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0048	0.0196
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0013	0.0018	0.0015
Brugia malayi	hypothetical protein	0.0016	0.0037	0.0159
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0146	0.0618
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.06	0.2585
Brugia malayi	Dopamine receptor	0.001	0.0001	0.0006
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0119	0.0504
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0098	0.0478	0.8263
Chlamydia trachomatis	aspartate--tRNA(Asp/Asn) ligase	0.0015	0.0029	0.0557
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.0401	0.3252
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0025	0.0083	0.1391
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0282	0.1219
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0098	0.0478	0.6134
Plasmodium falciparum	threonine--tRNA ligase	0.0025	0.0083	0.008
Echinococcus granulosus	General substrate transporter	0.0377	0.1984	0.8562
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Trypanosoma cruzi	metacaspase 5, putative	0.0018	0.0049	0.0596
Schistosoma mansoni	amine GPCR	0.001	0.0001	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trypanosoma brucei	glucose transporter 1E	0.0136	0.0684	0.879
Echinococcus granulosus	geminin	0.0169	0.0859	0.3703
Plasmodium falciparum	replication protein A1, large subunit	0.0012	0.0015	0.0012
Trypanosoma cruzi	hypothetical protein, conserved	0.0012	0.0015	0.0154
Echinococcus multilocularis	histidyl tRNA synthetase	0.0015	0.003	0.0122
Brugia malayi	Serotonin receptor	0.001	0.0001	0.0006
Giardia lamblia	Asparaginyl-tRNA synthetase	0.0015	0.0029	0.0403
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.071	0.3778	0.3776
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0146	0.0143
Entamoeba histolytica	histidyl-tRNA synthetase, putative	0.0015	0.003	0.0397
Onchocerca volvulus		0.0062	0.0282	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0083	0.0398	0.3229
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0018	0.0079
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0154	0.0778	0.1167
Plasmodium vivax	glycine--tRNA ligase, putative	0.0025	0.0083	0.008
Trypanosoma cruzi	Aminoacyl-tRNA editing domain containing protein, putative	0.0022	0.0067	0.0832
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0146	0.1103
Mycobacterium ulcerans	hypothetical protein	0.0022	0.0067	0.1121
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0049	0.02
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0029	0.0126
Brugia malayi	G-protein coupled receptor	0.001	0.0001	0.0006
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0091	0.0391
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0018	0.0324
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0456	0.1965
Trypanosoma brucei	Replication factor A protein 1	0.0012	0.0015	0.0154
Echinococcus multilocularis	asparaginyl tRNA synthetase	0.0015	0.0029	0.012
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.0281	0.1203
Brugia malayi	hypothetical protein	0.0062	0.0282	0.1219
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0083	0.0351
Echinococcus multilocularis	seryl tRNA synthetase, mitochondrial	0.001	0.0003	0.0006
Plasmodium falciparum	thioredoxin reductase	0.0013	0.0018	0.0015
Schistosoma mansoni	opsin-like receptor	0.001	0.0001	0.0006
Leishmania major	glycyl tRNA synthetase, putative	0.0015	0.003	0.0346
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0048	0.0196
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0091	0.0386
Plasmodium vivax	asparagine--tRNA ligase, putative	0.0015	0.0029	0.0026
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.001	0.0001	0.0006
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0025	0.0083	0.0121
Toxoplasma gondii	anticodon binding domain-containing protein	0.0015	0.003	0.004
Schistosoma mansoni	6-phosphofructokinase	0.0117	0.0578	0.2494
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0132	0.066	0.9744
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0049	0.02
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0159	0.0157
Schistosoma mansoni	biogenic amine receptor	0.001	0.0001	0.0006
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0135	0.0678	0.0675
Echinococcus granulosus	caspase	0.0018	0.0049	0.0206
Trypanosoma brucei	trypanothione reductase	0.0037	0.0148	0.1868
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0146	0.0623
Brugia malayi	MH2 domain containing protein	0.0121	0.06	0.259
Brugia malayi	phosphofructokinase	0.0117	0.0578	0.2494
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0148	0.0631
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0061	0.0281	0.1208
Toxoplasma gondii	ABC1 family protein	0.0036	0.0146	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0049	0.02
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.001	0.0001	0.0006
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0018	0.0199
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0135	0.0678	0.1016
Brugia malayi	6-phosphofructokinase	0.0117	0.0578	0.2494
Loa Loa (eye worm)	acetyltransferase	0.0144	0.0727	0.3135
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0146	0.1845
Echinococcus multilocularis	mitogen activated protein kinase	0.0061	0.0281	0.1208
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.001	0.0001	0.0006
Echinococcus multilocularis	lamin	0.0026	0.0091	0.0386
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0146	0.0618
Brugia malayi	Tachykinin-like peptides receptor 99D	0.001	0.0001	0.0006
Entamoeba histolytica	aspartyl-tRNA synthetase, putative	0.0015	0.0029	0.0392
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0146	0.2486
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0025	0.0083	0.0346
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0085	0.0082
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0048	0.0584
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0158	0.068
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0049	0.0596
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.0401	0.3252
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0146	0.2486
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0146	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Schistosoma mansoni	lysyl-tRNA synthetase	0.0098	0.0478	0.2063
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0117	0.0578	0.873
Trichomonas vaginalis	replication factor A 1, rfa1, putative	0.0012	0.0015	0.0052
Toxoplasma gondii	sugar transporter ST3	0.0062	0.0282	0.0421
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0135	0.0677	0.2918
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0018	0.055
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0018	0.0199
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0049	0.02
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0067	0.0279
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0025	0.0083	0.1391
Treponema pallidum	NADH oxidase	0.0013	0.0018	0.0268
Wolbachia endosymbiont of Brugia malayi	aspartyl-tRNA synthetase	0.0015	0.0029	0.0946
Brugia malayi	hypothetical protein	0.0025	0.0085	0.0366
Onchocerca volvulus		0.0062	0.0282	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0677	0.2918
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Brugia malayi	CXXC zinc finger family protein	0.0028	0.01	0.0431
Giardia lamblia	Aspartyl-tRNA synthetase	0.0015	0.0029	0.0403
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0146	0.1103
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0158	0.0674
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0049	0.0596
Mycobacterium leprae	conserved hypothetical protein	0.0022	0.0067	0.0815
Echinococcus granulosus	solute carrier family 22	0.0062	0.0282	0.1214
Echinococcus granulosus	calcium dependent protein kinase	0.0126	0.063	0.2713
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0684	0.2943
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0062	0.0282	0.1219
Toxoplasma gondii	replication factor-a protein 1 (rpa1) subfamily protein	0.0012	0.0015	0.0018
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.001	0.0001	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0282	0.1209
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Chlamydia trachomatis	histidine--tRNA ligase	0.0015	0.003	0.0564
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.001	0.0001	0.0006
Schistosoma mansoni	hypothetical protein	0.0043	0.0181	0.0781
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Echinococcus multilocularis	lamin dm0	0.0026	0.0091	0.0386
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0048	0.0584
Leishmania major	hypothetical protein, conserved	0.0036	0.0146	0.1845
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0031	0.0119	0.1729
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Trypanosoma cruzi	hexose transporter, putative	0.0062	0.0282	0.361
Plasmodium vivax	threonine--tRNA ligase, putative	0.0025	0.0083	0.008
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0049	0.0596
Brugia malayi	replication factor A 73 kDa subunit	0.0012	0.0015	0.0064
Echinococcus granulosus	asparaginyl tRNA synthetase, cytoplasmic	0.0015	0.0029	0.012
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0048	0.0201
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trichomonas vaginalis	phosphofructokinase, putative	0.0117	0.0578	0.2485
Onchocerca volvulus		0.0062	0.0282	1
Onchocerca volvulus		0.0028	0.01	0.3506
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0018	0.0071
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0119	0.0117
Echinococcus granulosus	lysyl tRNA synthetase	0.0098	0.0478	0.2058
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0117	0.0578	0.474
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.0401	0.3252
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0018	0.055
Leishmania major	glucose transporter, lmgt1	0.0136	0.0684	0.879
Leishmania major	myo-inositol/proton symporter (MIT)	0.0062	0.0282	0.361
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0132	0.066	0.2844
Brugia malayi	acetyltransferase, GNAT family protein	0.0144	0.0727	0.3139
Leishmania major	hypothetical protein, conserved	0.0022	0.0067	0.0832
Schistosoma mansoni	neuropeptide f receptor 76f	0.001	0.0001	0.0006
Schistosoma mansoni	glucose transport protein	0.0439	0.2317	1
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0029	0.0126
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Plasmodium vivax	hexose transporter	0.0439	0.2317	0.2315
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.0281	0.1203
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0178	0.0176
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0158	0.0674
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0048	0.1618
Trypanosoma cruzi	hypothetical protein, conserved	0.0022	0.0067	0.0832
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0132	0.066	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0013	0.0018	0.0199
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.06	0.2585
Schistosoma mansoni	biogenic amine receptor	0.001	0.0001	0.0006
Toxoplasma gondii	exonuclease III APE	0.0018	0.0048	0.0068
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Echinococcus granulosus	seryl tRNA synthetase mitochondrial	0.001	0.0003	0.0006
Brugia malayi	neuropeptide F receptor	0.001	0.0001	0.0006
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0146	0.0618
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0456	0.1965
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.001	0.0001	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Schistosoma mansoni	neuropeptide receptor	0.001	0.0001	0.0006
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0135	0.0678	0.1016
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0025	0.0083	0.0573
Echinococcus multilocularis	asparaginyl tRNA synthetase, cytoplasmic	0.0015	0.0029	0.012
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0048	0.0207
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0132	0.066	0.2839
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0025	0.0083	0.1033
Echinococcus granulosus	prolyl tRNA synthetase mitochondrial	0.001	0.0003	0.0006
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0135	0.0678	0.0675
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0135	0.0677	0.2918
Loa Loa (eye worm)	threonyl-tRNA synthetase	0.0025	0.0083	0.0351
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Echinococcus granulosus	intermediate filament protein	0.0026	0.0091	0.0386
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0086	0.0413	0.1772
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0012	0.0015	0.0154
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0061	0.0281	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Schistosoma mansoni	neuropeptide F-like receptor	0.001	0.0001	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0085	0.1059
Entamoeba histolytica	hypothetical protein	0.0039	0.0158	0.2295
Brugia malayi	Cam kinase protein 1	0.0135	0.0677	0.2922
Trichomonas vaginalis	esterase, putative	0.0036	0.0146	0.0618
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0054	0.0241	0.1035
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0048	0.0671
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.015	0.0643
Leishmania major	hypothetical protein, conserved	0.0022	0.0067	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0018	0.0071
Echinococcus multilocularis	replication protein A 70 kDa DNA binding	0.0012	0.0015	0.0058
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0272	0.1172
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0439	0.2317	1
Leishmania major	trypanothione reductase	0.0037	0.0148	0.1868
Onchocerca volvulus		0.0062	0.0282	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0253	0.0378
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0154	0.0778	1
Plasmodium vivax	6-phosphofructokinase, putative	0.0031	0.0119	0.0117
Trypanosoma brucei	metacaspase	0.0018	0.0049	0.0596
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0062	0.0282	0.1214
Echinococcus granulosus	lamin dm0	0.0026	0.0091	0.0386
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0146	0.1103
Mycobacterium tuberculosis	Probable reductase	0.0084	0.0401	0.3252
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Plasmodium vivax	histidine--tRNA ligase, putative	0.0015	0.003	0.0027
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0439	0.2317	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0439	0.2317	1
Brugia malayi	Major Facilitator Superfamily protein	0.0062	0.0282	0.1219
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0144	0.0727	0.3135
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0684	0.879
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0119	0.2453
Brugia malayi	hypothetical protein	0.0062	0.0282	0.1219
Trichomonas vaginalis	CMGC family protein kinase	0.0061	0.0281	0.1203
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0031	0.0119	0.0117
Schistosoma mansoni	caspase-7 (C14 family)	0.0061	0.028	0.121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0001	0.0006
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0146	0.0623
Schistosoma mansoni	hypothetical protein	0.001	0.0001	0.0006
Schistosoma mansoni	sugar transporter	0.0062	0.0282	0.1219
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0001	0.0006
Schistosoma mansoni	alpha-1 adrenergic receptor	0.001	0.0001	0.0006
Brugia malayi	threonyl-tRNA synthetase, cytoplasmic	0.0025	0.0083	0.0357
Echinococcus multilocularis	caspase 2	0.0061	0.028	0.1205
Brugia malayi	Aspartyl-tRNA synthetase	0.0015	0.0029	0.0126
Trichomonas vaginalis	conserved hypothetical protein	0.0136	0.0684	0.2943
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0439	0.2317	1
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0062	0.0282	0.1214
Trypanosoma cruzi	metacaspase 5, putative	0.0018	0.0049	0.0596
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0132	0.066	0.2848
Treponema pallidum	asparaginyl-tRNA synthetase	0.0015	0.0029	0.046
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0148	0.1868
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0018	0.0049	0.0206
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0098	0.0478	0.8263
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.001	0.0001	0.0006
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0148	0.0631
Brugia malayi	Sugar transporter family protein	0.0439	0.2317	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0117	0.0578	0.249
Schistosoma mansoni	hypothetical protein	0.0039	0.0158	0.068
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0148	0.0145
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0025	0.0083	0.1055
Entamoeba histolytica	hypothetical protein	0.0039	0.0158	0.2295
Brugia malayi	putative neuropeptide receptor	0.001	0.0001	0.0006
Trypanosoma brucei	glucose transporter 2A	0.0136	0.0684	0.879
Brugia malayi	glycyl-tRNA synthetase	0.0025	0.0083	0.0357
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0135	0.0678	0.0675
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0135	0.0678	0.0675
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0049	0.02
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0067	0.0442
Mycobacterium tuberculosis	Probable oxidoreductase	0.0093	0.0451	0.3676
Schistosoma mansoni	hypothetical protein	0.0012	0.0015	0.0063
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0025	0.0103
Mycobacterium ulcerans	integral membrane transport protein	0.0062	0.0282	0.4863
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0135	0.0678	0.0675
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0001	0.0006
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0018	0.0073
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0018	0.0199
Echinococcus multilocularis	aspartyl tRNA synthetase, cytoplasmic	0.0015	0.0029	0.012
Echinococcus granulosus	Seryl tRNA Synthetase	0.001	0.0003	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0146	0.0623
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.001	0.0001	0.0006
Trypanosoma cruzi	metacaspase, putative	0.0018	0.0049	0.0596
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0146	0.0623
Brugia malayi	beta-lactamase	0.0036	0.0146	0.0629
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0018	0.0049	0.007
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.0401	0.3252
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0098	0.0478	0.7182
Trypanosoma cruzi	asparaginyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Mycobacterium ulcerans	aspartyl-tRNA synthetase	0.0015	0.0029	0.046
Entamoeba histolytica	asparaginyl-tRNA synthetase, putative	0.0015	0.0029	0.0392
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0062	0.0282	0.4863
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0267	0.4602
Trypanosoma cruzi	sugar transporter, putative	0.0062	0.0282	0.361
Onchocerca volvulus		0.0062	0.0282	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0018	0.0199
Plasmodium vivax	asparagine--tRNA ligase, putative	0.0015	0.0029	0.0026
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0146	0.2486
Brugia malayi	Thioredoxin reductase	0.0037	0.0148	0.0637
Leishmania major	ATP-dependent phosphofructokinase	0.0117	0.0578	0.7424
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0456	0.1969
Echinococcus granulosus	caspase 8	0.0018	0.0049	0.0206
Trypanosoma cruzi	hexose transporter, putative	0.0136	0.0684	0.879
Brugia malayi	putative neuropeptide receptor NPR1	0.001	0.0001	0.0006
Brugia malayi	GnHR receptor homolog	0.001	0.0001	0.0006
Mycobacterium ulcerans	6-phosphofructokinase	0.0117	0.0578	1
Brugia malayi	seryl-tRNA synthetase, mitochondrial precursor, putative	0.001	0.0003	0.0012
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0084	0.0401	0.5989
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0178	0.0764
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0048	0.0787
Plasmodium vivax	sugar transporter, putative	0.0062	0.0282	0.028
Plasmodium falciparum	metacaspase-like protein	0.0018	0.0049	0.0046
Leishmania major	glucose transporter, lmgt3	0.0136	0.0684	0.879
Brugia malayi	AKH receptor	0.001	0.0001	0.0006
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0094	0.0456	0.1965
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0031	0.0119	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Mycobacterium ulcerans	histidyl-tRNA synthetase	0.0015	0.003	0.0466
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0048	0.0584
Echinococcus multilocularis	tumor protein p63	0.0408	0.215	0.9278
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0062	0.0282	0.1214
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0439	0.2317	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0146	0.0629
Onchocerca volvulus		0.0062	0.0282	1
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0148	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0091	0.0386
Toxoplasma gondii	protein kinase, putative	0.1241	0.6641	1
Entamoeba histolytica	hypothetical protein	0.0012	0.0015	0.0177
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0094	0.0456	0.1965
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0048	0.028
Brugia malayi	ORL1-like opioid receptor	0.001	0.0001	0.0006
Schistosoma mansoni	prolyl-tRNA synthetase	0.001	0.0003	0.0012
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0146	0.2031
Entamoeba histolytica	phosphofructokinase, putative	0.0117	0.0578	0.8529
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0001	0.0006
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0061	0.0281	0.3592
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0001	0.0006
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0146	0.0629
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0049	0.02
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0282	0.1214
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0267	0.4602
Echinococcus multilocularis	solute carrier family 22	0.0062	0.0282	0.1214
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0013	0.0018	0.0015
Schistosoma mansoni	seryl-tRNA synthetase	0.001	0.0003	0.0012
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0119	0.0504
Schistosoma mansoni	histidyl-tRNA synthetase	0.0015	0.003	0.0127
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0146	0.2031
Loa Loa (eye worm)	phosphofructokinase	0.0117	0.0578	0.249
Mycobacterium ulcerans	sugar transporter	0.0062	0.0282	0.4863
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.001	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0267	0.0399
Schistosoma mansoni	lysyl-tRNA synthetase	0.0098	0.0478	0.2063
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0062	0.0282	1
Brugia malayi	neuropeptide F receptor	0.001	0.0001	0.0006
Brugia malayi	beta-lactamase family protein	0.0036	0.0146	0.0629
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0093	0.0451	0.677
Toxoplasma gondii	transporter, major facilitator family protein	0.0062	0.0282	0.0421
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0048	0.0045
Schistosoma mansoni	glucose transport protein	0.0439	0.2317	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0085	0.0124
Onchocerca volvulus		0.0062	0.0282	1
Chlamydia trachomatis	threonine--tRNA ligase	0.0025	0.0083	0.1683
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0018	0.0199
Trypanosoma brucei	asparaginyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0013	0.0018	0.0029
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0018	0.0199
Schistosoma mansoni	protein kinase	0.0135	0.0677	0.2922
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0018	0.0078
Onchocerca volvulus	Cell death protein 3 homolog	0.0061	0.028	0.9928
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0025	0.0083	0.1033
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.001	0.0001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0282	0.1214
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0001	0.0006
Trypanosoma brucei	glucose transporter, putative	0.0136	0.0684	0.879
Plasmodium falciparum	mitogen-activated protein kinase 2	0.071	0.3778	0.3776
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0178	0.0264
Entamoeba histolytica	protein kinase, putative	0.0135	0.0677	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0013	0.0018	0.0234
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0094	0.0456	0.1969
Schistosoma mansoni	lamin	0.0026	0.0091	0.0391
Trichomonas vaginalis	phosphofructokinase, putative	0.0117	0.0578	0.2485
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0018	0.0049	0.007
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Echinococcus multilocularis	glycyl tRNA synthetase	0.0025	0.0083	0.0351
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.001	0.0001	0.0006
Schistosoma mansoni	aspartyl-tRNA synthetase	0.0015	0.0029	0.0126
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0012	0.0015	0.0012
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0135	0.0678	0.0675
Onchocerca volvulus		0.0036	0.0146	0.5136
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0282	0.1209
Echinococcus multilocularis	cpg binding protein	0.0029	0.0109	0.0463
Leishmania major	asparaginyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0061	0.0281	0.3592
Plasmodium vivax	aspartate--tRNA ligase, putative	0.0015	0.0029	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0067	0.0279
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0267	0.1149
Echinococcus granulosus	aspartyl tRNA synthetase cytoplasmic	0.0015	0.0029	0.012
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0049	0.02
Plasmodium falciparum	proline--tRNA ligase	0.0154	0.0778	0.0775
Echinococcus multilocularis	caspase 8	0.0018	0.0049	0.0206
Trichomonas vaginalis	glucose transporter, putative	0.0136	0.0684	0.2943
Treponema pallidum	glycyl-tRNA synthetase	0.0015	0.003	0.0466
Onchocerca volvulus		0.0026	0.0091	0.318
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0146	0.1103
Schistosoma mansoni	neuropeptide receptor	0.001	0.0001	0.0006
Echinococcus multilocularis	calcium dependent protein kinase	0.0126	0.063	0.2713
Giardia lamblia	Sugar-proton symporter	0.0062	0.0282	0.4257
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.001	0.0001	0.0006
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0154	0.0778	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0267	0.1154
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0018	0.0049	0.0211
Trichomonas vaginalis	conserved hypothetical protein	0.0018	0.0049	0.02
Brugia malayi	G protein-coupled receptor F59B2.13	0.001	0.0001	0.0006
Toxoplasma gondii	lysine-tRNA ligase	0.0098	0.0478	0.0716
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0146	0.1103
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0181	0.0776
Brugia malayi	lysyl-tRNA synthetase	0.0098	0.0478	0.2063
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0013	0.0018	0.0015
Leishmania major	threonyl-tRNA synthetase, putative	0.0025	0.0083	0.1033
Toxoplasma gondii	sugar transporter ST2	0.0062	0.0282	0.0421
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0148	0.0218
Entamoeba histolytica	glycyl-tRNA synthetase, putative	0.0025	0.0083	0.1186
Onchocerca volvulus		0.0043	0.0181	0.6392
Treponema pallidum	prolyl-tRNA synthetase	0.0047	0.02	0.3437
Schistosoma mansoni	glucose transporter	0.0062	0.0282	0.1219
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0043	0.0181	0.0776
Leishmania major	metacaspase, putative	0.0018	0.0049	0.0596
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0062	0.0282	0.028
Plasmodium falciparum	glutathione reductase	0.0037	0.0148	0.0145
Echinococcus granulosus	synaptic vesicle 2 protein	0.0062	0.0282	0.1214
Brugia malayi	6-phosphofructokinase	0.0117	0.0578	0.2494
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Brugia malayi	hypothetical protein	0.001	0.0001	0.0006
Trichomonas vaginalis	conserved hypothetical protein	0.0439	0.2317	1
Brugia malayi	G protein-coupled receptor	0.001	0.0001	0.0006
Chlamydia trachomatis	lysine--tRNA ligase	0.0098	0.0478	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0018	0.0199
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0049	0.02
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0018	0.0067
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.0401	0.3252
Brugia malayi	larval opioid receptor	0.001	0.0001	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0062	0.0282	0.1209
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.071	0.3778	0.5687
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0135	0.0678	0.0675
Toxoplasma gondii	6-phosphofructokinase	0.0031	0.0119	0.0176
Plasmodium falciparum	asparagine--tRNA ligase	0.0015	0.0029	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0061	0.028	0.1205
Trypanosoma brucei	protein kinase, putative	0.0061	0.0281	0.3592
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0135	0.0677	0.2922
Trypanosoma cruzi	aspartyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Echinococcus granulosus	replication protein A 70 kDa DNA binding	0.0012	0.0015	0.0058
Schistosoma mansoni	cpg binding protein	0.0029	0.0109	0.0468
Trichomonas vaginalis	phosphofructokinase, putative	0.0117	0.0578	0.2485
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0085	0.0082
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0067	0.0279
Schistosoma mansoni	threonyl-tRNA synthetase	0.0015	0.003	0.0127
Onchocerca volvulus		0.0036	0.0146	0.5136
Brugia malayi	MAP kinase sur-1	0.0061	0.0281	0.1213
Trichomonas vaginalis	phosphofructokinase, putative	0.0031	0.0119	0.0504
Schistosoma mansoni	hypothetical protein	0.001	0.0001	0.0006
Trichomonas vaginalis	CAMK family protein kinase	0.0135	0.0677	0.2914
Brugia malayi	Asparaginyl-tRNA synthetase, cytoplasmic	0.0015	0.0029	0.0126
Entamoeba histolytica	hypothetical protein	0.0039	0.0158	0.2295
Leishmania major	lysyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.001	0.0001	0.0006
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0015	0.0029	0.0341
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0049	0.02
Schistosoma mansoni	glycyl-tRNA synthetase	0.0025	0.0083	0.0357
Trichomonas vaginalis	aspartyl/lysyl-tRNA synthetase, putative	0.0015	0.0029	0.0114
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0018	0.0049	0.02

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 1.2589 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	26.6795 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1523500

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1400983