Detailed information for compound 1411497

Basic information

Technical information
  • TDR Targets ID: 1411497
  • Name: 3,4-dihydro-1H-isoquinolin-2-yl-[5-(4-fluorop henyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyri midin-3-yl]methanone
  • MW: 440.393 | Formula: C23H16F4N4O
  • H donors: 0 H acceptors: 3 LogP: 4 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1cc(n2c(n1)c(cn2)C(=O)N1CCc2c(C1)cccc2)C(F)(F)F
  • InChi: 1S/C23H16F4N4O/c24-17-7-5-15(6-8-17)19-11-20(23(25,26)27)31-21(29-19)18(12-28-31)22(32)30-10-9-14-3-1-2-4-16(14)13-30/h1-8,11-12H,9-10,13H2
  • InChiKey: VMXZOIDJCAZIOO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dihydro-1H-isoquinolin-2-yl-[5-(4-fluorophenyl)-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinyl]methanone
  • STK341018

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0461 0.1811
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.4153 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0147 0.0135
Entamoeba histolytica hypothetical protein 0.0042 0.0468 0.1127
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0461 0.0814
Onchocerca volvulus 0.002 0.0147 0.0118
Schistosoma mansoni cytochrome P450 0.0011 0.0013 0.0013
Onchocerca volvulus 0.0091 0.1173 0.119
Brugia malayi jmjC domain containing protein 0.0062 0.075 0.1068
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0034 0.0034
Echinococcus multilocularis bloom syndrome protein 0.002 0.0148 0.0136
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0034 0.0034
Echinococcus multilocularis geminin 0.0205 0.2818 0.2809
Giardia lamblia DINP protein human, muc B family 0.0021 0.0167 0.0083
Loa Loa (eye worm) hypothetical protein 0.0032 0.0314 0.0485
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.0222
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0034 0.0021
Brugia malayi cytochrome P450 0.0011 0.0013 0.0004
Schistosoma mansoni microtubule-associated protein tau 0.0701 1 1
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0088 0.0326
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0062 0.0757 0.0757
Echinococcus multilocularis microtubule associated protein 2 0.0701 1 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0062 0.0757 0.383
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0148 0.0568
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0134 0.0201
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0468 0.1859
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0034 0.0034
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0011 0.0013 0.0037
Echinococcus granulosus cpg binding protein 0.0037 0.0388 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0468 0.0832
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0134 0.048
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0088 0.0326
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0088 0.0088
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0006 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0461 0.1817
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0468 0.1127
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0129
Echinococcus multilocularis RUN 0.002 0.0147 0.0135
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0148 0.0589
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0461 0.1817
Trypanosoma brucei unspecified product 0.0035 0.0364 0.1431
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0034 0.0021
Loa Loa (eye worm) runx1 0.0056 0.0674 0.105
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0034 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0606 0.1176
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0964 0.1507
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4153 1
Toxoplasma gondii RNA-directed DNA polymerase 0.0184 0.2519 1
Brugia malayi ShTK domain containing protein 0.0091 0.1173 0.1677
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0461 0.1817
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0461 0.1817
Brugia malayi jmjC domain containing protein 0.0016 0.0088 0.0111
Entamoeba histolytica recQ family helicase, putative 0.002 0.0148 0.0358
Onchocerca volvulus 0.002 0.0147 0.0118
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.1173 0.1677
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0044
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0606 0.2389
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0101 0.0386
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0148 0.0199
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.00000000018881
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.007 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0964 0.0964
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0134 0.0516
Schistosoma mansoni coup transcription factor 0.0012 0.0034 0.0034
Leishmania major DNA polymerase kappa, putative 0.0021 0.0167 0.0613
Leishmania major telomerase reverse transcriptase, putative 0.0184 0.2519 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.007 0.0058
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0088 0.0129
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0088 0.0129
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0044
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0148 0.054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0034 0.0044
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0142 0.0543
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0006 0.0006
Brugia malayi Cytochrome P450 family protein 0.005 0.0574 0.0813
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0088 0.0333
Loa Loa (eye worm) hypothetical protein 0.005 0.0584 0.0909
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0062 0.0757 0.1078
Schistosoma mansoni rab6-interacting 0.002 0.0147 0.0147
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0606 0.0594
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0034 0.0021
Loa Loa (eye worm) doublecortin family protein 0.002 0.0147 0.0222
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0808 0.3208
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0606 0.2406
Loa Loa (eye worm) hypothetical protein 0.0091 0.1173 0.1834
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0606 0.0594
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.075 0.075
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0147 0.0135
Loa Loa (eye worm) RNA binding protein 0.0076 0.0964 0.1507
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0088 0.0348
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0148 0.0136
Schistosoma mansoni lozenge 0.0056 0.0674 0.0674
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0116 0.0104
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0148 0.0136
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.1956 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.1173 0.1834
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.1956 1
Loa Loa (eye worm) RecQ helicase 0.002 0.0148 0.0225
Echinococcus granulosus bloom syndrome protein 0.002 0.0148 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4153 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0148 0.0589
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0964 0.0964
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.007 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0034 0.0044
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0134 0.0178
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0461 0.0449
Loa Loa (eye worm) CYP4Cod1 0.002 0.0142 0.0214
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0034 0.0034
Schistosoma mansoni cpg binding protein 0.0037 0.0388 0.0388
Loa Loa (eye worm) tyrosinase 1 0.0091 0.1173 0.1834
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0134 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.075 0.117
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0006 0.0022
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0757 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0034 0.0034
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0669 0.0657
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0034 0.0021
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0148 0.0575
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0468 0.1565
Schistosoma mansoni hypothetical protein 0.0205 0.2818 0.2818
Echinococcus multilocularis 0.0011 0.0013 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.075 0.075
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0606 0.1176
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0034 0.0034
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0034 0.0021
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.7005 0.7001
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0088 0.0075
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0034 0.0034
Onchocerca volvulus 0.0091 0.1173 0.119
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4153 1
Schistosoma mansoni ap endonuclease 0.0019 0.0134 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0461 0.1811
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0964 0.0964
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0012 0.0011
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0606 0.2366
Echinococcus multilocularis dna polymerase eta 0.0015 0.007 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0034 0.0021
Schistosoma mansoni loxhd1 0.002 0.0147 0.0147
Brugia malayi polk-prov protein 0.0032 0.0314 0.0438
Schistosoma mansoni rab6-interacting 0.002 0.0147 0.0147
Brugia malayi Telomerase reverse transcriptase 0.0489 0.694 1
Brugia malayi beta-NAC-like protein 0.0042 0.0468 0.066
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0964 0.1376
Echinococcus granulosus transcription factor btf3 0.0042 0.0468 0.0456
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.007 0.0101
Brugia malayi ecdysteroid receptor 0.0012 0.0034 0.0034
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0088 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0461 0.1817
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0468 0.184
Onchocerca volvulus 0.045 0.6367 0.662
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0606 0.0606
Mycobacterium tuberculosis Conserved hypothetical protein 0.0015 0.007 0.0292
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0034 0.0034
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0147 0.0135
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0359 0.0555
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0034 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0134 0.0509
Loa Loa (eye worm) hypothetical protein 0.045 0.6367 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0167 0.0613
Schistosoma mansoni lipoxygenase 0.002 0.0147 0.0147
Brugia malayi RNA binding protein 0.0076 0.0964 0.1376
Schistosoma mansoni hypothetical protein 0.002 0.0147 0.0147
Brugia malayi nuclear hormone receptor 0.0012 0.0034 0.0034
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0134 0.062
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0468 0.1859
Echinococcus granulosus phd:f box containing protein 0.0016 0.0088 0.0075
Trypanosoma brucei protein kinase, putative 0.0052 0.0606 0.2395
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0148 0.0136
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0034 0.0034
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0461 0.0814
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0964 0.0964
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4153 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0461 0.1817
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0088 0.0075
Brugia malayi hypothetical protein 0.045 0.6367 0.9174
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0088 0.0075
Plasmodium falciparum telomerase reverse transcriptase 0.0184 0.2519 1
Giardia lamblia Telomerase catalytic subunit 0.0184 0.2519 0.5934
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0606 0.2389
Brugia malayi Doublecortin family protein 0.002 0.0147 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0147 0.0222
Onchocerca volvulus 0.0035 0.0359 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0034 0.0044
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0669 0.0657
Brugia malayi TAR-binding protein 0.0076 0.0964 0.1376
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0101 0.0386
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0091 0.1173 0.1677
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0062 0.0757 0.0746
Schistosoma mansoni ap endonuclease 0.0019 0.0134 0.0134
Onchocerca volvulus 0.0091 0.1173 0.119
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0648
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0088 0.0088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4153 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0148 0.025
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.075 0.0739
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0722 0.071
Echinococcus granulosus tumor protein p63 0.0343 0.4824 0.4817
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0364 0.1431
Schistosoma mansoni polycystin 1-related 0.002 0.0147 0.0147
Schistosoma mansoni DNA polymerase eta 0.0015 0.007 0.007
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0314 0.1233
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0034 0.0034
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0606 0.2389
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0034 0.0034
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0142 0.0214
Echinococcus granulosus tar DNA binding protein 0.0076 0.0964 0.0953
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0142 0.0663
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0148 0.025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0757 0.383
Brugia malayi jmjC domain containing protein 0.0016 0.0088 0.0111
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0034 0.0034
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0088 0.0348
Leishmania major basic transcription factor 3a, putative 0.0042 0.0468 0.1816
Brugia malayi MAP kinase sur-1 0.0052 0.0606 0.086
Schistosoma mansoni hypothetical protein 0.0011 0.0013 0.0013
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0142 0.0214
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0147 0.0135
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0964 0.0964
Loa Loa (eye worm) hypothetical protein 0.0091 0.1173 0.1834
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0088 0.0075
Echinococcus multilocularis Protein lozenge 0.0056 0.0674 0.0662
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0034 0.0034
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0034 0.0021
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0584 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0468 0.0832
Schistosoma mansoni jumonji domain containing protein 0.006 0.0722 0.0722
Brugia malayi jmjC domain containing protein 0.006 0.0722 0.1026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0134 0.0121
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0088 0.0075
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0606 0.1176
Entamoeba histolytica deoxycytidyl transferase, putative 0.0015 0.007 0.0168
Echinococcus multilocularis cpg binding protein 0.0037 0.0388 0.0376
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0088 0.0129
Trypanosoma brucei telomerase reverse transcriptase 0.0184 0.2519 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0034 0.0021
Brugia malayi CXXC zinc finger family protein 0.0035 0.0359 0.0503
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0461 0.1817
Trypanosoma brucei cytochrome P450, putative 0.002 0.0142 0.0549
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0034 0.0034
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.0574 0.0894
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.4153 1
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0148 0.0199
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.4153 1
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0468 0.1846
Echinococcus granulosus RUN 0.002 0.0147 0.0135
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0088 0.0088
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0148 0.0225
Schistosoma mansoni hypothetical protein 0.0494 0.7005 0.7005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0034 0.0034
Schistosoma mansoni transcription factor btf3 0.0042 0.0468 0.0468
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0673 0.9602 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0134 0.053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0034 0.0034
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0606 0.1176
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0013 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4153 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0015 0.007 0.0256
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0148 0.0037
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0606 0.0594
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.1956 1
Schistosoma mansoni hypothetical protein 0.0205 0.2818 0.2818
Schistosoma mansoni lipoxygenase 0.0056 0.0669 0.0669
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0088 0.0075
Brugia malayi Common central domain of tyrosinase family protein 0.0091 0.1173 0.1677
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0148 0.0136
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.4153 1
Schistosoma mansoni tyrosinase precursor 0.0091 0.1173 0.1173
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0142 0.0543
Brugia malayi steroid hormone receptor 0.0012 0.0034 0.0034
Onchocerca volvulus 0.005 0.0584 0.0575
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0148 0.0037
Schistosoma mansoni DNA helicase recq5 0.002 0.0148 0.0148
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0461 0.1817
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0134 0.0121
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0034 0.0021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0034 0.0034
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0964 0.0953
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0184 0.2519 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0017 0.0101 0.0386
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0722 0.071
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0034 0.0021
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0034 0.0034
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.1173 0.1677
Loa Loa (eye worm) hypothetical protein 0.0015 0.007 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0314 0.1233
Loa Loa (eye worm) hypothetical protein 0.002 0.0148 0.0225
Echinococcus granulosus geminin 0.0205 0.2818 0.2809
Echinococcus granulosus dna polymerase kappa 0.0042 0.0461 0.0449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0034 0.0044
Echinococcus granulosus dna polymerase eta 0.0015 0.007 0.0058
Brugia malayi hypothetical protein 0.002 0.0147 0.0197
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0147 0.0584
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0034 0.0034
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0088 0.0088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0134 0.0509
Loa Loa (eye worm) cytochrome P450 0.0011 0.0013 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0034 0.0034
Plasmodium vivax telomerase reverse transcriptase, putative 0.0184 0.2519 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0644 0.1003
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0034 0.0034
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0461 0.2304
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0468 0.0832
Brugia malayi hypothetical protein 0.002 0.0147 0.0197
Entamoeba histolytica recQ family DNA helicase 0.001 0.0006 0.0014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0034 0.0021
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.007 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0461 0.1817
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.1173 0.1834
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0034 0.0034
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0013 0.003
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.007 0.0086
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0606 0.0594
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0922 0.0922
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0606 0.1176
Brugia malayi Cytochrome P450 family protein 0.002 0.0142 0.019
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0147 0.0135
Plasmodium vivax JmjC domain containing protein 0.0016 0.0088 0.0348
Brugia malayi jmjC domain containing protein 0.0016 0.0088 0.0111
Trypanosoma brucei DNA polymerase eta, putative 0.0015 0.007 0.0263
Schistosoma mansoni tyrosinase precursor 0.0091 0.1173 0.1173
Leishmania major hypothetical protein, conserved 0.0016 0.0088 0.0297
Toxoplasma gondii exonuclease III APE 0.0019 0.0134 0.053
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.007 0.007
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0088 0.0075
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0134 0.0322
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0147 0.0244
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0044
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0134 0.062
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0148 0.0199
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0184 0.2519 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0134 0.0189
Brugia malayi nuclear receptor NHR-88 0.0012 0.0034 0.0034
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0011 0.002 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0034 0.0021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0034 0.0021
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0034 0.0021
Echinococcus granulosus dnaJ subfamily B 0.0494 0.7005 0.7001
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0606 0.0944
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0034 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0034 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0461 0.2304
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0606 0.2389
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.1173 0.1677
Onchocerca volvulus 0.0091 0.1173 0.119
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0134 0.0309
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4153 1
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0468 0.0727
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0129
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0722 0.071
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0044
Loa Loa (eye worm) hypothetical protein 0.045 0.6367 1
Leishmania major cytochrome p450-like protein 0.002 0.0142 0.0514
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0461 0.1817
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0034 0.0021
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0116 0.0104
Brugia malayi Cytochrome P450 family protein 0.0011 0.0013 0.0004
Leishmania major DNA polymerase eta, putative 0.0015 0.007 0.0226
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0034 0.0021
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0034 0.0044
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0034 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.4153 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0044
Echinococcus multilocularis transcription factor btf3 0.0042 0.0468 0.0456
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0461 0.1811
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0011 0.0013 0.003
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0011 0.0013 0.003
Brugia malayi Cytochrome P450 family protein 0.002 0.0142 0.019
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0964 0.1507
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0044
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0062 0.0757 0.2969
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0044
Schistosoma mansoni cpg binding protein 0.0037 0.0388 0.0388
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0606 0.2366
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0034 0.0034
Brugia malayi jmjC domain containing protein 0.0016 0.0088 0.0111
Schistosoma mansoni cpg binding protein 0.0035 0.0359 0.0359
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0461 0.1817
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0147 0.0135
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0148 0.0037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0088 0.0129
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0148 0.0037
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0034 0.0034
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0167 0.0791
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0013 0.0001
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0468 0.184
Schistosoma mansoni DNA helicase recq1 0.002 0.0148 0.0148
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0606 0.2395
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0062 0.0757 0.383
Echinococcus multilocularis tumor protein p63 0.0343 0.4824 0.4817
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0034 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0461 0.1811

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 12.088 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) = 36.962 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 60.1198 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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