Detailed information for compound 1413079

Basic information

Technical information
  • TDR Targets ID: 1413079
  • Name: 3-(methyl-phenylsulfamoyl)-N-(5-prop-2-enylsu lfanyl-1,3,4-thiadiazol-2-yl)benzamide
  • MW: 446.566 | Formula: C19H18N4O3S3
  • H donors: 1 H acceptors: 5 LogP: 3.73 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCSc1nnc(s1)NC(=O)c1cccc(c1)S(=O)(=O)N(c1ccccc1)C
  • InChi: 1S/C19H18N4O3S3/c1-3-12-27-19-22-21-18(28-19)20-17(24)14-8-7-11-16(13-14)29(25,26)23(2)15-9-5-4-6-10-15/h3-11,13H,1,12H2,2H3,(H,20,21,24)
  • InChiKey: CTDRRYIPQMAFJO-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(5-allylsulfanyl-1,3,4-thiadiazol-2-yl)-3-(methyl-phenyl-sulfamoyl)benzamide
  • N-[5-(allylthio)-1,3,4-thiadiazol-2-yl]-3-(methyl-phenylsulfamoyl)benzamide
  • N-[5-(allylthio)-1,3,4-thiadiazol-2-yl]-3-(methyl-phenyl-sulfamoyl)benzamide
  • 3-(methyl-phenyl-sulfamoyl)-N-(5-prop-2-enylsulfanyl-1,3,4-thiadiazol-2-yl)benzamide
  • ZINC02639339
  • T5270789
  • MLS000393843
  • SMR000247901

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0179 0.1924 0.1826
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0662 0.0549
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0054 0.0381 0.0264
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.008 0.0708 0.0627
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2408 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.3472 0.5923
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0179 0.1924 0.2957
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0662 0.1182
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0477 0.56 1
Giardia lamblia GTOR 0.0477 0.56 1
Loa Loa (eye worm) hypothetical protein 0.0307 0.351 0.4026
Loa Loa (eye worm) intermediate filament protein 0.0033 0.012 0.0138
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0381 0.0264
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0381 0.0437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0429 0.5012 0.4951
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0429 0.5012 0.8872
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0429 0.5012 0.4951
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0095 0.089 0.0779
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0662 0.0549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0381 0.4417 0.7733
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0477 0.56 0.5547
Brugia malayi FAT domain containing protein 0.0094 0.0879 0.157
Entamoeba histolytica hypothetical protein 0.0134 0.137 0.1896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.2531 0.412
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0095 0.089 0.0976
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0452 0.5293 0.9412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0381 0.4417 0.7733
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0134 0.137 0.2446
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0134 0.137 0.1265
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0095 0.089 0.0976
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0662 0.0549
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0669 0.0552
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0452 0.5293 0.9412
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0429 0.5012 0.8872
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0429 0.5012 0.4951
Brugia malayi TAR-binding protein 0.0076 0.0662 0.1182
Schistosoma mansoni survival motor neuron protein 0.0058 0.0437 0.0321
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0271 0.306 0.5134
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0054 0.0381 0.0264
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0228 0.2531 0.412
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0477 0.56 1
Leishmania major cathepsin L-like protease 0.0077 0.0669 0.0552
Schistosoma mansoni hypothetical protein 0.0094 0.0879 0.0768
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0179 0.1924 0.2957
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.3476 0.593
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0054 0.0381 0.0264
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0307 0.351 0.6267
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0477 0.56 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Leishmania major phosphatidylinositol 3-kinase, putative 0.0228 0.2531 0.412
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0477 0.56 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.56 1
Trypanosoma cruzi hypothetical protein, conserved 0.009 0.0834 0.0869
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0095 0.089 0.0976
Loa Loa (eye worm) hypothetical protein 0.0145 0.1502 0.1723
Echinococcus multilocularis 0.0054 0.0381 0.0264
Loa Loa (eye worm) hypothetical protein 0.0148 0.1544 0.1771
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3242 0.3159
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0669 0.0552
Leishmania major cathepsin L-like protease 0.0077 0.0669 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0271 0.306 0.5134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.3714 0.6387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0307 0.351 0.3431
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0207 0.2266 0.3613
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Onchocerca volvulus 0.0054 0.0381 0.1138
Leishmania major cathepsin L-like protease 0.0077 0.0669 0.0552
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.04 0.4659 0.8197
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0452 0.5293 0.9452
Loa Loa (eye worm) phosphatidylinositol 3 0.0477 0.56 0.6423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0383 0.4439 0.7776
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0708 0.0627
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0095 0.089 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1544 0.1771
Loa Loa (eye worm) phosphatidylinositol kinase 0.0054 0.0381 0.0437
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.0381 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0669 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.1542 0.2224
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0662 0.076
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0179 0.1924 0.2957
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.012 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.3256 0.5509
Echinococcus multilocularis geminin 0.0205 0.2243 0.2149
Entamoeba histolytica protein kinase rad3, putative 0.0134 0.137 0.1896
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0095 0.089 0.1263
Schistosoma mansoni hypothetical protein 0.0058 0.0437 0.0321
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.024 0.2674 0.4394
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0452 0.5293 0.9412
Brugia malayi intermediate filament protein 0.0033 0.012 0.0215
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0309 0.3527 0.3449
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0477 0.56 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0113 0.0129
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0095 0.089 0.159
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0134 0.137 0.1265
Brugia malayi N-terminal motif family protein 0.0218 0.2408 0.43
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0381 0.068
Loa Loa (eye worm) hypothetical protein 0.0094 0.0879 0.1009
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0381 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.032 0.3666 0.6294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.3476 0.593
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0095 0.089 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.2531 0.412
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0381 0.0437
Trichomonas vaginalis conserved hypothetical protein 0.0094 0.0879 0.0956
Trichomonas vaginalis PIKK family atypical protein kinase 0.0381 0.4417 0.7733
Brugia malayi hypothetical protein 0.0148 0.1544 0.2757
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0095 0.089 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.137 0.1896
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0095 0.089 0.0976
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0477 0.56 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.3472 0.5923
Leishmania major hypothetical protein, conserved 0.0144 0.1496 0.2137
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0368 0.4259 0.7431
Loa Loa (eye worm) hypothetical protein 0.0033 0.012 0.0138
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0813 0.9752 0.9749
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0134 0.137 0.1265
Onchocerca volvulus 0.0054 0.0381 0.1138
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0307 0.351 0.3431
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0095 0.089 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.4655 0.819
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0662 0.0549
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0662 0.076
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0323 0.3708 0.6374
Trichomonas vaginalis PIKK family atypical protein kinase 0.0177 0.1899 0.291
Echinococcus multilocularis Zinc finger, PHD finger 0.0095 0.089 0.0779
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0586 0.0394
Loa Loa (eye worm) hypothetical protein 0.0043 0.0248 0.0284
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0095 0.089 0.0976
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0429 0.5012 0.8949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.3476 0.593
Schistosoma mansoni hypothetical protein 0.0205 0.2243 0.2149
Loa Loa (eye worm) hypothetical protein 0.0218 0.2408 0.2762
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0452 0.5293 0.9412
Echinococcus granulosus geminin 0.0205 0.2243 0.2149
Trypanosoma brucei target of rapamycin kinase 3, putative 0.04 0.4659 0.8197
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0134 0.137 0.1896
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0095 0.089 0.0976
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0813 0.9752 0.9749
Schistosoma mansoni fkbp-rapamycin associated protein 0.0134 0.137 0.1265
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0094 0.0879 0.0768
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0095 0.089 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.3476 0.593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.3472 0.5923
Leishmania major phosphatidylinositol 3-kinase, putative 0.0095 0.089 0.0976
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.4655 0.819
Loa Loa (eye worm) hypothetical protein 0.0134 0.137 0.1571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.2531 0.412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.56 1
Brugia malayi RNA binding protein 0.0076 0.0662 0.1182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0324 0.3714 0.6387
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3242 0.3159
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0477 0.56 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Mycobacterium leprae conserved hypothetical protein 0.0054 0.0381 0.5
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0125 0.1262 0.1689
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0095 0.089 0.0779
Loa Loa (eye worm) phosphatidylinositol 3 0.0729 0.8718 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0134 0.137 0.1896
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0361 0.4178 0.746
Echinococcus granulosus serine protein kinase ATM 0.0134 0.137 0.1265
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.012 0.0215
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0179 0.1924 0.2957
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0095 0.089 1
Onchocerca volvulus Huntingtin homolog 0.0148 0.1544 0.6222
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0134 0.137 0.1896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0381 0.4417 0.7733
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0477 0.56 0.5547
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0095 0.089 0.0779
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0398 0.4631 0.8143
Loa Loa (eye worm) RNA binding protein 0.0076 0.0662 0.076
Schistosoma mansoni hypothetical protein 0.0205 0.2243 0.2149
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0177 0.1899 0.291
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0381 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0134 0.137 0.1896
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0437 0.078
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.4655 0.819
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0094 0.0879 0.0768
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0381 0.0264
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0669 0.0552
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0179 0.1924 0.2957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0477 0.56 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0125 0.1262 0.1448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0228 0.2531 0.412
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.4655 0.819
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0223 0.2476 0.4014
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0095 0.089 0.0976
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0271 0.306 0.5134
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0137 0.1415 0.1981
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0179 0.1924 0.3436
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0477 0.56 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0381 0.0437
Loa Loa (eye worm) hypothetical protein 0.0076 0.0659 0.0756
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Brugia malayi hypothetical protein 0.0286 0.3242 0.5788
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0708 0.0627
Toxoplasma gondii FATC domain-containing protein 0.0134 0.137 0.2451
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0381 0.0264
Loa Loa (eye worm) hypothetical protein 0.0043 0.0248 0.0284
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0452 0.5293 0.9412
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0662 0.0549
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0179 0.1924 0.2957
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0477 0.56 0.5547
Loa Loa (eye worm) phosphatidylinositol 3 0.0271 0.306 0.351
Echinococcus granulosus tar DNA binding protein 0.0076 0.0662 0.0549
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0179 0.1924 0.2957
Trypanosoma cruzi target of rapamycin kinase 3 0.04 0.4659 0.8197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.0669 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0381 0.4417 0.7733
Loa Loa (eye worm) hypothetical protein 0.0286 0.3242 0.3718
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0813 0.9752 0.9749
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0309 0.3527 0.3449
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0054 0.0381 0.0264
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0095 0.089 0.1021
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0452 0.5293 0.9412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.3256 0.5509
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0224 0.2486 0.4034
Toxoplasma gondii target of rapamycin (TOR), putative 0.0381 0.4417 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.1322 0.1803
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0054 0.0381 0.0264
Loa Loa (eye worm) hypothetical protein 0.0148 0.1542 0.1768
Trichomonas vaginalis PIKK family atypical protein kinase 0.0381 0.4417 0.7733
Loa Loa (eye worm) hypothetical protein 0.008 0.0708 0.0812
Schistosoma mansoni hypothetical protein 0.0054 0.0381 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.3494 0.5966
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0662 0.0549
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0381 0.068
Onchocerca volvulus Huntingtin homolog 0.0148 0.1544 0.6222
Onchocerca volvulus 0.0058 0.0437 0.1385
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0148 0.1542 0.2876
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0095 0.089 0.0779
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0134 0.137 0.2446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.3256 0.5509
Echinococcus multilocularis serine protein kinase ATM 0.0134 0.137 0.1265
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0477 0.56 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0465 0.0163
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0381 0.0437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0381 0.4417 0.7733
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0323 0.3708 0.6374
Trichomonas vaginalis PIKK family atypical protein kinase 0.04 0.4655 0.819
Entamoeba histolytica hypothetical protein 0.0368 0.4259 0.7431

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.3109 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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