Detailed information for compound 1416814

Basic information

Technical information
  • TDR Targets ID: 1416814
  • Name: 2-[5-(4-methylphenyl)-4-oxothieno[2,3-d]pyrim idin-3-yl]acetonitrile
  • MW: 281.332 | Formula: C15H11N3OS
  • H donors: 0 H acceptors: 2 LogP: 2.68 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CCn1cnc2c(c1=O)c(cs2)c1ccc(cc1)C
  • InChi: 1S/C15H11N3OS/c1-10-2-4-11(5-3-10)12-8-20-14-13(12)15(19)18(7-6-16)9-17-14/h2-5,8-9H,7H2,1H3
  • InChiKey: ILGDIZUFDLDPCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[5-(4-methylphenyl)-4-oxo-thieno[2,3-d]pyrimidin-3-yl]acetonitrile
  • 2-[5-(4-methylphenyl)-4-oxo-3-thieno[2,3-d]pyrimidinyl]acetonitrile
  • 2-[4-keto-5-(4-methylphenyl)thieno[2,3-d]pyrimidin-3-yl]acetonitrile
  • 2-[5-(4-methylphenyl)-4-oxo-thieno[2,3-d]pyrimidin-3-yl]ethanenitrile
  • SMR000289658
  • Oprea1_282188
  • T5600179
  • (4-Oxo-5-p-tolyl-4H-thieno[2,3-d]pyrimidin-3-yl)-acetonitrile
  • BAS 03754368
  • ZINC00098487
  • MLS000708891

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0069 0.0069
Echinococcus multilocularis GPCR, family 2 0.0049 0.088 0.088
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0063 0.0063
Onchocerca volvulus 0.001 0.0063 0.0119
Onchocerca volvulus 0.001 0.0069 0.013
Schistosoma mansoni cpg binding protein 0.0035 0.0579 0.0579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0063 0.0063
Echinococcus granulosus g protein coupled receptor 0.001 0.0063 0.0063
Schistosoma mansoni biogenic amine receptor 0.001 0.0063 0.0063
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0063 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0063 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0118 0.0118
Echinococcus granulosus son of sevenless 1 0.0007 0.0012 0.0012
Onchocerca volvulus 0.001 0.0063 0.0119
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.2939 0.2939
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0063 0.0063
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0063 0.0119
Brugia malayi nuclear receptor NHR-88 0.0012 0.0118 0.0223
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0001
Brugia malayi DIX domain containing protein 0.001 0.0069 0.013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0226 0.0226
Onchocerca volvulus 0.0035 0.0579 0.1089
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0063 0.0063
Brugia malayi CXXC zinc finger family protein 0.0035 0.0579 0.1089
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0118 0.0118
Echinococcus granulosus orexin receptor type 2 0.001 0.0063 0.0063
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0118 0.0223
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0118 0.0223
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0226 0.1409
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0069 0.0069
Echinococcus granulosus Smad4 0.0009 0.0046 0.0046
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.088 0.088
Brugia malayi G-protein coupled receptor 0.001 0.0063 0.0119
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0118 0.0118
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0012 0.0012
Schistosoma mansoni smad1 5 8 and 0.0009 0.0046 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0156 0.3067 0.5766
Brugia malayi Melatonin receptor type 1A 0.001 0.0063 0.0119
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0063 0.0119
Echinococcus granulosus neuropeptide receptor 0.001 0.0063 0.0063
Brugia malayi GnHR receptor homolog 0.001 0.0063 0.0119
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0455 0.9201 1
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Brugia malayi isocitrate dehydrogenase 0.0017 0.0226 0.0425
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.2939 0.2939
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0012 0.0013
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0063 0.0063
Echinococcus granulosus neuropeptide receptor 0.001 0.0063 0.0063
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0063 0.0119
Echinococcus granulosus tar DNA binding protein 0.0129 0.2516 0.2516
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0118 0.0118
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0118 0.0223
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0063 0.0119
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0063 0.0063
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0118 0.0223
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1372 0.1372
Echinococcus multilocularis g protein coupled receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0063 0.0119
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0226 0.0226
Schistosoma mansoni dishevelled 0.001 0.0069 0.0069
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0063 0.0119
Schistosoma mansoni dep domain containing protein 0.001 0.0069 0.0069
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.2939 0.2939
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0063 0.0063
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0118 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.0032
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0063 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni smad 0.0009 0.0046 0.0046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1372 0.0221
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.1533 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0063 0.0063
Echinococcus granulosus g-protein coupled receptor 0.001 0.0063 0.0063
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0065 0.1195 0.108
Loa Loa (eye worm) hypothetical protein 0.0081 0.1533 0.2882
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0063 0.0119
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0063 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0063 0.0063
Brugia malayi RNA binding protein 0.0129 0.2516 0.473
Onchocerca volvulus 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.0032
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.088 0.1655
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0118 0.0223
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0069 0.013
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0063 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0063 0.0063
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0012 0.0022
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0045 0.0045
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.1533 1
Plasmodium vivax ornithine aminotransferase, putative 0.0065 0.1195 0.7415
Schistosoma mansoni tar DNA-binding protein 0.0129 0.2516 0.2516
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0118 0.0223
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0069 0.0069
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.001 0.0063 0.0063
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Echinococcus multilocularis serotonin receptor 0.001 0.0063 0.0063
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.013
Schistosoma mansoni biogenic amine receptor 0.001 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.0032
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0069 0.0069
Onchocerca volvulus 0.001 0.0063 0.0119
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0007 0.0012 0.0022
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1372 0.8772
Schistosoma mansoni hypothetical protein 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0007 0.0012 0.0012
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0226 0.1409
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0049 0.088 0.088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0118 0.0223
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0579 0.1089
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus fmrfamide receptor 0.001 0.0063 0.0063
Plasmodium falciparum ornithine aminotransferase 0.0065 0.1195 0.7415
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.088 0.088
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.088 0.088
Schistosoma mansoni hypothetical protein 0.0494 1 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0063 0.0063
Echinococcus granulosus GPCR family 2 0.0049 0.088 0.088
Brugia malayi Latrophilin receptor protein 2 0.0049 0.088 0.1655
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0063 0.0063
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0118 0.0118
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.088 0.1655
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0088 0.0166
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0118 0.0223
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0065 0.1195 0.108
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Brugia malayi Dopamine receptor protein 2 0.001 0.0063 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.0032
Echinococcus multilocularis fmrfamide receptor 0.001 0.0063 0.0063
Echinococcus multilocularis somatostatin receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0001
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0063 0.0063
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0045 0.0045
Brugia malayi AKH receptor 0.001 0.0063 0.0119
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0063 0.0063
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0069 0.0069
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0226 0.0226
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0063 0.0063
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0118 0.0118
Brugia malayi ORL1-like opioid receptor 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus smad 0.0009 0.0046 0.0046
Onchocerca volvulus 0.0012 0.0118 0.0223
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0063 0.0063
Schistosoma mansoni amine GPCR 0.001 0.0063 0.0063
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0118 0.0118
Schistosoma mansoni opsin-like receptor 0.001 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0049 0.088 0.088
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Onchocerca volvulus 0.001 0.0063 0.0119
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0063 0.0119
Schistosoma mansoni cpg binding protein 0.0037 0.062 0.062
Schistosoma mansoni adenoreceptor 0.001 0.0063 0.0063
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0007 0.0012 0.0013
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0118 0.0118
Schistosoma mansoni regulator of G protein signaling 0.001 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.2474 0.4652
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.0032
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0046 0.0046
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0012 0.0012
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Brugia malayi MH2 domain containing protein 0.0009 0.0046 0.0086
Schistosoma mansoni neuropeptide receptor 0.001 0.0063 0.0063
Schistosoma mansoni neuropeptide receptor 0.001 0.0063 0.0063
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0118 0.0118
Echinococcus multilocularis ras GTP exchange factor 0.0007 0.0012 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0063 0.0063
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0063 0.0063
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.2055 0.3863
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1372 0.1372
Brugia malayi Calcitonin receptor-like protein seb-1 0.0156 0.3067 0.5766
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0118 0.0118
Schistosoma mansoni amine GPCR 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1372 0.0221
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0063 0.0063
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0046 0.0046
Echinococcus granulosus neuropeptide s receptor 0.001 0.0063 0.0063
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0012 0.0012
Onchocerca volvulus 0.001 0.0063 0.0119
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0063 0.0063
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0063 0.0063
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0065 0.1195 0.108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0049 0.088 0.088
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0069 0.013
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Loa Loa (eye worm) TAR-binding protein 0.0129 0.2516 0.473
Onchocerca volvulus 0.001 0.0063 0.0119
Echinococcus multilocularis ornithine aminotransferase 0.0065 0.1195 0.1195
Echinococcus granulosus ornithine aminotransferase 0.0065 0.1195 0.1195
Schistosoma mansoni biogenic amine receptor 0.001 0.0063 0.0063
Echinococcus granulosus somatostatin receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.013
Onchocerca volvulus 0.001 0.0063 0.0119
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0118 0.0118
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0118 0.0223
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0223
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0226 0.0425
Brugia malayi Pax transcription factor protein 2 0.0266 0.5319 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0063 0.0063
Trichomonas vaginalis helicase, putative 0.0008 0.0029 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0118 0.0223
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0085 0.016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0223
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0118 0.0118
Onchocerca volvulus 0.001 0.0063 0.0119
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0007 0.0005 0.0005
Brugia malayi Serotonin receptor 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0069 0.013
Echinococcus granulosus cpg binding protein 0.0037 0.062 0.062
Brugia malayi larval opioid receptor 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.0107 0.2055 0.3863
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0007 0.0012 0.0012
Schistosoma mansoni amine GPCR 0.001 0.0063 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0118 0.0223
Echinococcus multilocularis smad 0.0009 0.0046 0.0046
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0063 0.0119
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.1533 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0615 0.0615
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0455 0.9201 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0118 0.0118
Mycobacterium tuberculosis Probable aminotransferase 0.0455 0.9201 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0063 0.0063
Schistosoma mansoni dishevelled 0.001 0.0069 0.0069
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0069 0.013
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0118 0.0118
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0063 0.0063
Echinococcus granulosus Protein son of sevenless 0.0007 0.0012 0.0012
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0063 0.0063
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0223
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0046 0.0086
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0118 0.0118
Brugia malayi N-terminal motif family protein 0.0007 0.0012 0.0022
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.2474 0.4652
Echinococcus granulosus allatostatin A receptor 0.001 0.0063 0.0063
Brugia malayi RasGEF domain containing protein 0.0007 0.0012 0.0022
Echinococcus granulosus Aminotransferase class III 0.0065 0.1195 0.1195
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0065 0.1195 0.2246
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.2939 0.2939
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0063 0.0119
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0069 0.0069
Schistosoma mansoni tar DNA-binding protein 0.0129 0.2516 0.2516
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0156 0.3067 0.5766
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Brugia malayi Dopamine receptor 0.001 0.0063 0.0119
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0063 0.0063
Schistosoma mansoni amine GPCR 0.001 0.0063 0.0063
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0063 0.0063
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0046 0.0046
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1372 0.1372
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Brugia malayi Dopamine receptor protein 1 0.001 0.0063 0.0119
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Brugia malayi RE15519p 0.001 0.0063 0.0119
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0063 0.0119
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0118 0.0118
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0007 0.0012 0.0012
Onchocerca volvulus 0.001 0.0063 0.0119
Schistosoma mansoni Smad4 0.0009 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0049 0.088 0.088
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0063 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0063 0.0063
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0063 0.0063
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0226 0.107
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0063 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.0049 0.088 0.1655
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni opsin-like receptor 0.001 0.0063 0.0063
Brugia malayi neuropeptide F receptor 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0199 0.3957 0.7439
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0012 0.0012
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Echinococcus multilocularis Aminotransferase class III 0.0065 0.1195 0.1195
Onchocerca volvulus 0.0266 0.5319 1
Leishmania major hypothetical protein, conserved 0.0081 0.1533 1
Echinococcus multilocularis son of sevenless 1 0.0007 0.0012 0.0012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0226 0.0226
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0012 0.0012
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0063 0.0063
Echinococcus multilocularis tar DNA binding protein 0.0129 0.2516 0.2516
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1372 0.8903
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0063 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.2939 0.5526
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0118 0.0223
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0069 0.0069
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0065 0.1195 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0063 0.0063
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0063 0.0063
Brugia malayi MH1 domain containing protein 0.0009 0.0046 0.0086
Brugia malayi sulfakinin receptor protein 0.001 0.0063 0.0119
Echinococcus multilocularis allatostatin A receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0063 0.0063
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1372 0.1372
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0118 0.0223
Schistosoma mansoni smad1 5 8 and 0.0009 0.0046 0.0046
Onchocerca volvulus 0.001 0.0063 0.0119
Echinococcus multilocularis fmrfamide receptor 0.001 0.0063 0.0063
Brugia malayi Serotonin receptor 0.001 0.0063 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0063 0.0063
Echinococcus granulosus sex peptide receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0046 0.0086
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.088 0.088
Loa Loa (eye worm) RNA binding protein 0.0129 0.2516 0.473
Schistosoma mansoni hypothetical protein 0.0107 0.2055 0.2055
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0118 0.0223
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0455 0.9201 1
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0 0.0001
Schistosoma mansoni hypothetical protein 0.001 0.0063 0.0063
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0118 0.0223
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0226 0.0226
Brugia malayi RasGEF domain containing protein 0.0007 0.0012 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0088 0.0088
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0118 0.0223
Loa Loa (eye worm) hypothetical protein 0.001 0.0069 0.013
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0615 0.0615
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0063 0.0063
Brugia malayi hypothetical protein 0.0006 0 0.0001
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.2939 0.5526
Loa Loa (eye worm) hypothetical protein 0.0006 0 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.0032
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0266 0.5319 1
Schistosoma mansoni myosin xvIII 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.2939 0.2939
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0065 0.1195 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0118 0.0118
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0063 0.0063
Echinococcus multilocularis g protein coupled receptor 0.001 0.0063 0.0063
Echinococcus granulosus g protein coupled receptor 0.001 0.0063 0.0063
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.1533 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1372 0.1277
Brugia malayi follicle stimulating hormone receptor 0.001 0.0063 0.0119
Brugia malayi N-terminal motif family protein 0.0199 0.3957 0.7439
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.2939 0.2939
Brugia malayi RasGEF domain containing protein 0.0007 0.0012 0.0022
Brugia malayi hypothetical protein 0.0052 0.0943 0.1772
Brugia malayi TAR-binding protein 0.0129 0.2516 0.473
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0223
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0455 0.9201 1
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0007 0.0012 1
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0063 0.0063
Echinococcus granulosus hypothetical protein 0.001 0.0063 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0129 0.2516 0.2516
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0069 0.0069
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0063 0.0063
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0029 0.0032
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0046 0.0046
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0063 0.0063
Echinococcus multilocularis serotonin receptor 0.001 0.0063 0.0063
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0223
Schistosoma mansoni neuropeptide receptor 0.001 0.0063 0.0063
Onchocerca volvulus 0.001 0.0063 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.0032
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0063 0.0063
Brugia malayi N-terminal motif family protein 0.0007 0.0012 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0063 0.0063
Onchocerca volvulus 0.001 0.0063 0.0119
Mycobacterium ulcerans hypothetical protein 0.0455 0.9201 1
Schistosoma mansoni hypothetical protein 0.0036 0.0615 0.0615
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0118 0.0118
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0069 0.0069
Brugia malayi ecdysteroid receptor 0.0012 0.0118 0.0223
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0118 0.0118
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0006 0 0.0001
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 0.3957 0.7439
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0063 0.0063
Brugia malayi hypothetical protein 0.001 0.0069 0.013
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0012 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0118 0.0223
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0045
Onchocerca volvulus 0.001 0.0063 0.0119
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Brugia malayi Smad1 0.0009 0.0046 0.0086
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0007 0.0012 0.0013
Echinococcus multilocularis ornithine aminotransferase 0.0065 0.1195 0.1195
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0069 0.0069
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0063 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0063 0.0063
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0063 0.0063
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0118 0.0223
Onchocerca volvulus 0.001 0.0063 0.0119
Echinococcus multilocularis neuropeptide receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0156 0.3067 0.5766
Onchocerca volvulus 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.2516 0.473
Brugia malayi MH2 domain containing protein 0.0127 0.2474 0.4652
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0065 0.1195 0.7692
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0063 0.0119
Brugia malayi hypothetical protein 0.0081 0.1533 0.2882
Brugia malayi G-protein coupled receptor 0.001 0.0063 0.0119
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.1533 1
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0063 0.0063
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.0032
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0118 0.0118
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1372 0.0221
Schistosoma mansoni smad1 5 8 and 0.0009 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0223
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0065 0.1195 0.1195
Schistosoma mansoni tar DNA-binding protein 0.0129 0.2516 0.2516
Onchocerca volvulus 0.0007 0.0012 0.0022
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.1533 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0088 0.0088
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0118 0.0223
Schistosoma mansoni cpg binding protein 0.0037 0.062 0.062
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni histamine h1 receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0118 0.0223
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0029 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0118 0.0118
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0063 0.0063
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0118 0.0118
Onchocerca volvulus Neuropeptide F receptor homolog 0.001 0.0063 0.0119
Echinococcus granulosus g protein coupled receptor 0.001 0.0063 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0118 0.0223
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0063 0.0063
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0065 0.1195 0.108
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0063 0.0119
Trichomonas vaginalis ras GTP exchange factor, putative 0.0007 0.0012 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0118 0.0223
Echinococcus granulosus ras GTP exchange factor 0.0007 0.0012 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0063 0.0063
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0063 0.0063
Brugia malayi MH2 domain containing protein 0.0009 0.0046 0.0086
Brugia malayi nuclear hormone receptor 0.0012 0.0118 0.0223
Onchocerca volvulus 0.001 0.0063 0.0119
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0012 0.0118 0.0223
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0226 0.0425
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0118 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.0006 0 0.0001
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0063 0.0063
Echinococcus multilocularis orexin receptor type 2 0.001 0.0063 0.0063
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.2939 0.2939
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0007 0.0012 0.0012
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0069 0.0069
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0069 0.013
Echinococcus granulosus serotonin receptor 0.001 0.0063 0.0063
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0118 0.0118
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0226 0.0226
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1377 0.1377
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0063 0.0063
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0063 0.0063
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0063 0.0063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0029 0.0032
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0118 0.0223
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0063 0.0063
Echinococcus multilocularis Protein son of sevenless 0.0007 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.1533 1
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0063 0.0119
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0063 0.0063
Echinococcus multilocularis neuropeptide receptor 0.001 0.0063 0.0063
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.001 0.0063 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0118 0.0223
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0063 0.0063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Brugia malayi hypothetical protein 0.0006 0 0.0001
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0045 0.0045
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0063 0.0063
Echinococcus multilocularis sex peptide receptor 0.001 0.0063 0.0063
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0069 0.013
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Schistosoma mansoni coup transcription factor 0.0012 0.0118 0.0118
Echinococcus multilocularis Smad4 0.0009 0.0046 0.0046
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0063 0.0119
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0226 0.107
Brugia malayi nuclear receptor RXR 0.0006 0 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0022
Brugia malayi putative neuropeptide receptor 0.001 0.0063 0.0119
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0063 0.0063
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0118 0.0223
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Schistosoma mansoni amine GPCR 0.001 0.0063 0.0063
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.2516 0.473
Brugia malayi MH1 domain containing protein 0.0009 0.0046 0.0086
Loa Loa (eye worm) Smad1 0.0009 0.0046 0.0086
Echinococcus multilocularis g protein coupled receptor 0.001 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0029 0.0032
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0063 0.0063
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0063 0.0063
Brugia malayi hypothetical protein 0.001 0.0069 0.013
Brugia malayi neuropeptide F receptor 0.001 0.0063 0.0119
Loa Loa (eye worm) hypothetical protein 0.001 0.0063 0.0119
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1216 0.7835
Schistosoma mansoni opsin-like receptor 0.001 0.0063 0.0063
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0063 0.0119
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0012 1
Echinococcus multilocularis cpg binding protein 0.0037 0.062 0.062
Brugia malayi G protein-coupled receptor 0.001 0.0063 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0118 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0118 0.0223
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0118 0.0118
Brugia malayi hypothetical protein 0.001 0.0063 0.0119
Brugia malayi steroid hormone receptor 0.0012 0.0118 0.0223
Schistosoma mansoni neuropeptide receptor 0.001 0.0063 0.0063
Schistosoma mansoni tar DNA-binding protein 0.0129 0.2516 0.2516
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0063 0.0119

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.