Detailed information for compound 1420717

Basic information

Technical information
  • TDR Targets ID: 1420717
  • Name: N-(4-fluorophenyl)-1-benzofuran-2-carboxamide
  • MW: 255.244 | Formula: C15H10FNO2
  • H donors: 1 H acceptors: 1 LogP: 3.59 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)NC(=O)c1cc2c(o1)cccc2
  • InChi: 1S/C15H10FNO2/c16-11-5-7-12(8-6-11)17-15(18)14-9-10-3-1-2-4-13(10)19-14/h1-9H,(H,17,18)
  • InChiKey: FEUYULCIWUILDN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(4-fluorophenyl)benzofuran-2-carboxamide
  • N-(4-fluorophenyl)-2-benzofurancarboxamide
  • Oprea1_451362
  • BAS 00713043
  • Benzofuran-2-carboxylic acid (4-fluoro-phenyl)-amide
  • ST5185492
  • AG-690/37123081
  • ZINC00133052
  • Oprea1_204396

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens Niemann-Pick disease, type C1 Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica Niemann-Pick C1 protein, putative Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus Niemann Pick C1 protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Candida albicans potential membrane protein similar to S. cerevisiae NCR1 (YPL006W) and human NPC1 late endosomal protein involved in sterol home Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum Niemann-Pick C1 protein precursor, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi Niemann-Pick C1 protein precursor Get druggable targets OG5_128206 All targets in OG5_128206
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni niemann-pick C1 (NPC1) Get druggable targets OG5_128206 All targets in OG5_128206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_128206 All targets in OG5_128206
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K07003 Niemann Pick type C1, putative Get druggable targets OG5_128206 All targets in OG5_128206
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128206 All targets in OG5_128206
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0381 0.3822
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0059 0.0365
Onchocerca volvulus 0.0012 0.0059 0.0977
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0154 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.002 0.0043
Loa Loa (eye worm) patched family protein 0.0007 0.0008 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0381 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0154 0.391
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0059 0.0512
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0059 0.0112
Loa Loa (eye worm) HMP-2 protein 0.0059 0.0537 0.465
Loa Loa (eye worm) hypothetical protein 0.0021 0.0154 0.1329
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Echinococcus multilocularis protein patched 0.0051 0.0458 0.0458
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.002 0.0201
Entamoeba histolytica hypothetical protein 0.0043 0.038 0.3171
Trichomonas vaginalis esterase, putative 0.0043 0.0381 0.3822
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0142 0.048
Trypanosoma cruzi hypothetical protein, conserved 0.0067 0.0619 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.002 0.0174
Toxoplasma gondii ABC1 family protein 0.0043 0.0381 0.6102
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Echinococcus multilocularis expressed conserved protein 0.0067 0.0619 0.0619
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Schistosoma mansoni hypothetical protein 0.0043 0.038 0.2346
Loa Loa (eye worm) hypothetical protein 0.0021 0.0154 0.1329
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0142 0.048
Brugia malayi hypothetical protein 0.0043 0.038 0.329
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0059 0.0112
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0174
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0119 0.1156 1
Toxoplasma gondii propionate-CoA ligase 0.0008 0.002 0.0201
Brugia malayi nuclear hormone receptor 0.0012 0.0059 0.0512
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0059 0.0059
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0458 0.0871
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.3293
Loa Loa (eye worm) oxidoreductase 0.0008 0.002 0.0174
Onchocerca volvulus 0.0043 0.0381 0.7093
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Entamoeba histolytica hypothetical protein 0.01 0.0963 0.8305
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0059 0.0112
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Echinococcus multilocularis proteasome assembly chaperone 2 0.01 0.0963 0.0963
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0257 0.6561
Mycobacterium ulcerans hypothetical protein 0.0031 0.0257 0.6561
Entamoeba histolytica hypothetical protein 0.0043 0.038 0.3171
Brugia malayi hypothetical protein 0.0067 0.0619 0.5354
Loa Loa (eye worm) hypothetical protein 0.0021 0.0154 0.1329
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0059 0.0512
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0059 0.0112
Echinococcus granulosus beta catenin 0.0059 0.0537 0.1021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0228 0.0791
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0381 0.3822
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0059 0.0059
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0228 0.5766
Schistosoma mansoni hypothetical protein 0.0143 0.1403 0.8655
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1973
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Echinococcus multilocularis expressed conserved protein 0.0164 0.1621 0.1621
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0059 0.0977
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.168 0.168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0512
Onchocerca volvulus 0.0043 0.0381 0.7093
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0059 0.0365
Brugia malayi Patched related family protein 12 0.0007 0.0008 0.0068
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0059 0.0059
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0228 0.5766
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0512
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0059 0.0059
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0059 0.0512
Brugia malayi protein C24B5.3 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0062 0.0576 0.4985
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0059 0.0512
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0154 0.3703
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0381 0.0724
Onchocerca volvulus 0.0043 0.0381 0.7093
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.038 0.2346
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0059 0.0112
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0043
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.1156 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0154 0.1329
Brugia malayi Armadillo/beta-catenin-like repeat family protein 0.0059 0.0537 0.465
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0059 0.0512
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0059 0.0512
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.002 0.0043
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0059 0.0112
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0512
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0228 0.5766
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0008 0.002 0.0174
Schistosoma mansoni hypothetical protein 0.0164 0.1621 1
Brugia malayi beta-lactamase family protein 0.0043 0.0381 0.3293
Brugia malayi hypothetical protein 0.0007 0.0008 0.0068
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0228 0.5766
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) patched family protein 0.0007 0.0008 0.0068
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0228 0.183
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0059 0.0059
Brugia malayi AMP-binding enzyme family protein 0.0008 0.002 0.0174
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0059 0.0365
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0059 0.0512
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0381 0.134
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0381 0.134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0059 0.0512
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.002 0.0174
Brugia malayi steroid hormone receptor 0.0012 0.0059 0.0512
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0059 0.0512
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0059 0.0059
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0043
Onchocerca volvulus 0.0008 0.002 0.0234
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0059 0.0365
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0228 0.183
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.002 0.002
Mycobacterium tuberculosis Conserved protein 0.0043 0.0381 0.134
Brugia malayi CHE-14 protein 0.0051 0.0458 0.3964
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0381 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0059 0.0512
Mycobacterium ulcerans beta-lactamase 0.0043 0.0381 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0154 0.0523
Brugia malayi AMP-binding enzyme family protein 0.0008 0.002 0.0174
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0381 0.3293
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.002 0.0174
Onchocerca volvulus 0.0029 0.0228 0.4189
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0381 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0381 0.6022
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0228 0.1973
Entamoeba histolytica hypothetical protein 0.0043 0.038 0.3171
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.1156 0.1156
Echinococcus multilocularis protein dispatched 1 0.0058 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Echinococcus granulosus proteasome assembly chaperone 2 0.01 0.0963 0.1831
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0228 0.5766
Mycobacterium ulcerans lipase LipD 0.0043 0.0381 1
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.002 0.0043
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0228 0.0791
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.3293
Mycobacterium leprae Probable lipase LipE 0.0043 0.0381 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0458 0.4644
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0059 0.0059
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0228 0.5766
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0059 0.0512
Brugia malayi Patched protein homolog 1 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0512
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0458 0.0458
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0059 0.0112
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1973
Schistosoma mansoni patched 1 0.0051 0.0458 0.2826
Schistosoma mansoni hypothetical protein 0.0031 0.0257 0.1583
Schistosoma mansoni hypothetical protein 0.01 0.0963 0.5942
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0381 0.3293
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0059 0.0512
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0059 0.0365
Mycobacterium tuberculosis Conserved protein 0.0043 0.0381 0.134
Echinococcus multilocularis expressed conserved protein 0.0112 0.1082 0.1082
Echinococcus granulosus hypothetical protein 0.0143 0.1403 0.2667
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0381 0.6022
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0381 0.134
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0059 0.0512
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0458 0.0871
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0154 0.5
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0381 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0381 0.3822
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.002 0.0201
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0142 0.048
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0381 0.134
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.002 0.0043
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0059 0.0365
Brugia malayi AMP-binding enzyme family protein 0.0008 0.002 0.0174
Schistosoma mansoni coup transcription factor 0.0012 0.0059 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0059 0.0512
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.002 0.0174
Trichomonas vaginalis hypothetical protein 0.01 0.0963 1
Brugia malayi beta-lactamase family protein 0.0043 0.0381 0.3293
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0512
Onchocerca volvulus 0.0008 0.002 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0059 0.0512
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0059 0.0512
Mycobacterium tuberculosis Conserved hypothetical protein 0.0031 0.0257 0.0894
Onchocerca volvulus 0.0008 0.002 0.0234
Mycobacterium ulcerans hypothetical protein 0.0043 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0512
Echinococcus granulosus protein pangolin J 0.0145 0.1427 0.2712
Loa Loa (eye worm) hypothetical protein 0.0051 0.0458 0.3964
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Brugia malayi hypothetical protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0228 0.5766
Brugia malayi Patched related family protein 10 0.0007 0.0008 0.0068
Echinococcus granulosus expressed conserved protein 0.0067 0.0619 0.1176
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0228 0.5766
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0059 0.0512
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Onchocerca volvulus 0.0008 0.002 0.0234
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0059 0.0365
Loa Loa (eye worm) patched family protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.3293
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0059 0.0365
Brugia malayi AMP-binding enzyme family protein 0.0008 0.002 0.0174
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Mycobacterium ulcerans hypothetical protein 0.0031 0.0257 0.6561
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0228 0.183
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Toxoplasma gondii hypothetical protein 0.0067 0.0619 1
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0381 0.134
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.002 0.0043
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.002 0.0038
Mycobacterium ulcerans hypothetical protein 0.0029 0.0228 0.5766
Loa Loa (eye worm) hypothetical protein 0.0021 0.0154 0.1329
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.002 0.0043
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0059 0.0365
Echinococcus granulosus expressed conserved protein 0.0518 0.5261 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0059 0.0512
Brugia malayi ecdysteroid receptor 0.0012 0.0059 0.0512
Schistosoma mansoni hypothetical protein 0.0049 0.0439 0.2709
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0228 0.5766
Loa Loa (eye worm) hypothetical protein 0.0029 0.0228 0.1973
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0059 0.0512
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0059 0.0512
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0381 0.3822
Schistosoma mansoni hypothetical protein 0.0049 0.0439 0.2709
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0059 0.0365
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.3293
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0059 0.0365
Entamoeba histolytica hypothetical protein 0.0043 0.038 0.3171
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0228 0.1973
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0381 0.0381
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0257 0.6561
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0142 0.048
Brugia malayi beta-lactamase 0.0043 0.0381 0.3293
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0458 0.3964
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.1175 0.7245
Schistosoma mansoni beta-catenin 0.0059 0.0537 0.3315
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.038 0.0723
Loa Loa (eye worm) hypothetical protein 0.0012 0.0059 0.0512
Brugia malayi protein C24B5.3 0.0007 0.0008 0.0068
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.002 0.0043
Brugia malayi hypothetical protein 0.0007 0.0008 0.0068
Onchocerca volvulus Cirhin homolog 0.0058 0.0533 1
Schistosoma mansoni hypothetical protein 0.0049 0.0439 0.2709
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.3293
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0059 0.0112
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.168 0.3194
Echinococcus multilocularis beta catenin 0.0059 0.0537 0.0537
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0381 0.134
Brugia malayi Myosin head containing protein 0.0007 0.0008 0.0068
Leishmania major hypothetical protein, conserved 0.0043 0.0381 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0059 0.0512
Brugia malayi hypothetical protein 0.0007 0.0008 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0059 0.0112
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0059 0.0977
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0381 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0228 0.5766
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0228 0.5766
Loa Loa (eye worm) hypothetical protein 0.0043 0.0381 0.3293
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0059 0.0512
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) beta-lactamase 0.0043 0.0381 0.3293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0381 0.2348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0059 0.0059
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Echinococcus granulosus expressed conserved protein 0.0112 0.1082 0.2056
Mycobacterium tuberculosis Conserved alanine and leucine rich protein 0.0031 0.0257 0.0894
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0228 0.1973
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.002 0.033
Schistosoma mansoni hypothetical protein 0.0049 0.0439 0.2709
Mycobacterium tuberculosis Conserved protein 0.0043 0.0381 0.134
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0228 0.5766
Brugia malayi Patched family protein 0.0007 0.0008 0.0068
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.1156 0.2197
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.002 0.0844
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.038 0.038
Echinococcus multilocularis protein pangolin J 0.0145 0.1427 0.1427
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.002 0.0043
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.1156 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0059 0.0365
Brugia malayi nuclear receptor NHR-88 0.0012 0.0059 0.0512
Brugia malayi Patched related family protein 4 0.0007 0.0008 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0059 0.0512
Loa Loa (eye worm) patched family protein 0.0007 0.0008 0.0068
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0381 0.2348
Loa Loa (eye worm) patched family protein 0.0007 0.0008 0.0068
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.002 0.0124
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2789 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0381 0.134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0059 0.0512
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0059 0.0977
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0381 0.3822

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.9528 uM PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8273 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Potentiators of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.3109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.2495 uM PUBCHEM_BIOASSAY: qHTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for NPC1 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.1714 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 5.8584 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.7456 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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