Detailed information for compound 142679

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 549.595 | Formula: C28H27N3O7S
  • H donors: 3 H acceptors: 7 LogP: 4.56 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C1NC(=O)C(S1)Cc1ccc(cc1)OC[C@@H]1CCCN1c1ccc2c(n1)cccc2.OC(=O)/C=C\C(=O)O
  • InChi: 1S/C24H23N3O3S.C4H4O4/c28-23-21(31-24(29)26-23)14-16-7-10-19(11-8-16)30-15-18-5-3-13-27(18)22-12-9-17-4-1-2-6-20(17)25-22;5-3(6)1-2-4(7)8/h1-2,4,6-12,18,21H,3,5,13-15H2,(H,26,28,29);1-2H,(H,5,6)(H,7,8)/b;2-1-/t18-,21?;/m0./s1
  • InChiKey: KNLAOHQNTRJBLS-VUOUBCMLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0011 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Loa Loa (eye worm) hypothetical protein 0.0163 0.0317 0.046
Echinococcus multilocularis Glutaredoxin protein 5 0.0017 0.0018 0.0039
Schistosoma mansoni 60S ribosomal protein L21 0.0048 0.0081 0.0094
Brugia malayi neuropeptide F receptor 0.006 0.0105 0.0103
Schistosoma mansoni growth hormone secretagogue receptor 0.006 0.0105 0.0123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0086 0.018
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0111 0.0211 0.025
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.002 0.0024 0.0032
Entamoeba histolytica protein kinase, putative 0.0031 0.0048 0.0527
Toxoplasma gondii selenide, water dikinase 0.0013 0.0011 0.0285
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0015 0.0162
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.006 0.0105 0.0257
Echinococcus granulosus short transient receptor potential channel 6 0.0044 0.0073 0.0177
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.277 0.5642 0.5641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0005 0.0051
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0044 0.0073 0.0071
Loa Loa (eye worm) hypothetical protein 0.2924 0.5957 0.8687
Echinococcus multilocularis allatostatin A receptor 0.006 0.0105 0.0257
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0044 0.0073 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0086 0.018
Brugia malayi Protein kinase domain containing protein 0.0031 0.0048 0.0046
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.0092 0.0107
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.0073 0.0177
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0073 0.2559
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0011 0.0285
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0044 0.0073 0.0177
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.005 0.0086 0.01
Echinococcus multilocularis voltage dependent calcium channel 0.0044 0.0073 0.0177
Loa Loa (eye worm) hypothetical protein 0.0103 0.0195 0.0281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0086 0.018
Brugia malayi Serotonin receptor 0.006 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus multilocularis stromal cell derived factor 2 0.0434 0.0869 0.2155
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.006 0.0105 0.0151
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0044 0.0073 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.0159 0.0187
Echinococcus granulosus hypothetical protein 0.006 0.0105 0.0257
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0434 0.0869 0.1035
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0017 0.0018 0.0039
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.0073 0.0177
Entamoeba histolytica MIR domain protein 0.0434 0.0869 1
Onchocerca volvulus 0.0084 0.0155 0.1679
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0024 0.0026
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Trypanosoma brucei cyclin 2 0.0009 0.0003 0.0006
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0049 0.0084 0.0204
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0044 0.0073 0.0177
Trichomonas vaginalis AGC family protein kinase 0.002 0.0024 0.0268
Echinococcus granulosus g protein coupled receptor 0.006 0.0105 0.0257
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.003 0.0328
Echinococcus granulosus shaker cognate 0.0044 0.0073 0.0177
Onchocerca volvulus 0.0018 0.0021 0.0118
Plasmodium falciparum ferrodoxin reductase-like protein 0.0013 0.0011 0.0285
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0013 0.0011 0.0113
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0044 0.0073 0.0085
Schistosoma mansoni transient receptor potential channel 4 0.0044 0.0073 0.0085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0011 0.0116
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.0073 0.0177
Echinococcus multilocularis G protein coupled receptor 139 0.006 0.0105 0.0257
Trichomonas vaginalis CMGC family protein kinase 0.0016 0.0016 0.0177
Loa Loa (eye worm) hypothetical protein 0.1308 0.2655 0.387
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0044 0.0073 0.0071
Schistosoma mansoni neuropeptide f receptor 76f 0.006 0.0105 0.0123
Brugia malayi Serotonin/octopamine receptor family protein 7 0.006 0.0105 0.0103
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0011 0.0113
Echinococcus multilocularis serotonin receptor 0.006 0.0105 0.0257
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0105 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0013 0.0137
Trichomonas vaginalis AGC family protein kinase 0.0031 0.0048 0.0539
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0003 0.0029
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.006 0.0105 0.0123
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0049 0.0084 0.0204
Brugia malayi Transient-receptor-potential like protein 0.0044 0.0073 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0105 0.0257
Echinococcus granulosus orexin receptor type 2 0.006 0.0105 0.0257
Mycobacterium tuberculosis Probable oxidoreductase 0.005 0.0086 0.2803
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0044 0.0073 0.0177
Loa Loa (eye worm) hypothetical protein 0.0163 0.0317 0.046
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0105 0.0257
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0086 0.018
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0011 0.0022
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0013 0.0011 0.0009
Loa Loa (eye worm) thioredoxin reductase 0.0144 0.0278 0.0402
Brugia malayi glutamate synthase 0.0013 0.0011 0.0009
Leishmania major hypothetical protein, conserved 0.0013 0.0011 0.0033
Brugia malayi Protein kinase domain containing protein 0.002 0.0024 0.0022
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0044 0.0073 0.0177
Echinococcus multilocularis potassium large conductance calcium activated 0.0044 0.0073 0.0177
Trichomonas vaginalis CMGC family protein kinase 0.0016 0.0016 0.0177
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus granulosus somatostatin receptor 0.006 0.0105 0.0257
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.005 0.0086 0.0265
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0105 0.0123
Echinococcus granulosus glutamate synthase 0.0013 0.0011 0.0022
Leishmania major NADH dehydrogenase, putative 0.0013 0.0011 0.0033
Toxoplasma gondii thioredoxin reductase 0.0144 0.0278 1
Schistosoma mansoni hypothetical protein 0.006 0.0105 0.0123
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.0073 0.0177
Schistosoma mansoni myosin xvIII 0.006 0.0105 0.0123
Echinococcus granulosus serine threonine protein kinase nrc 0.0017 0.0019 0.0041
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.006 0.0105 0.0123
Echinococcus granulosus sex peptide receptor 0.006 0.0105 0.0257
Brugia malayi G protein-coupled receptor 0.006 0.0105 0.0103
Schistosoma mansoni opsin-like receptor 0.006 0.0105 0.0123
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0011 0.0113
Echinococcus multilocularis serotonin receptor 0.006 0.0105 0.0257
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0011 0.0113
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0082 0.0151 0.0218
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0009 0.0001 0.0002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.005 0.0086 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0053 0.0092 0.0223
Loa Loa (eye worm) hypothetical protein 0.1979 0.4026 0.587
Brugia malayi Dopamine receptor 0.006 0.0105 0.0103
Echinococcus granulosus alpha 1A adrenergic receptor 0.006 0.0105 0.0257
Trichomonas vaginalis mannosyltransferase 1, putative 0.0434 0.0869 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0003 0.0029
Brugia malayi gonadotropin-releasing hormone receptor 2 0.006 0.0105 0.0103
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0082 0.0151 0.0371
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0105 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0011 0.0116
Brugia malayi G-protein coupled receptor 0.006 0.0105 0.0103
Trypanosoma brucei cdc2-related kinase 1 0.0016 0.0016 0.0034
Leishmania major hypothetical protein, conserved 0.0013 0.0011 0.0033
Trichomonas vaginalis AGC family protein kinase 0.002 0.0024 0.0268
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0016 0.0016 0.0021
Echinococcus granulosus two pore calcium channel protein 1 0.0044 0.0073 0.0177
Echinococcus granulosus 7TM GPCR rhodopsin 0.006 0.0105 0.0257
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.002 0.0024 0.0055
Echinococcus multilocularis orexin receptor type 2 0.006 0.0105 0.0257
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0011 0.0023
Trypanosoma brucei NADH dehydrogenase 0.0013 0.0011 0.0023
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0061 0.0108 0.0227
Schistosoma mansoni biogenic amine receptor 0.006 0.0105 0.0123
Brugia malayi Melatonin receptor type 1A 0.006 0.0105 0.0103
Echinococcus granulosus dro:myosuppressin receptor 0.006 0.0105 0.0257
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0013 0.0011 0.0023
Schistosoma mansoni amine GPCR 0.006 0.0105 0.0123
Schistosoma mansoni transient receptor potential channel 0.0044 0.0073 0.0085
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0105 0.0257
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0105 0.0257
Echinococcus multilocularis g protein coupled receptor 0.006 0.0105 0.0257
Trichomonas vaginalis 1-phosphatidylinositol phosphodiesterase, putative 0.0018 0.0021 0.0229
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0044 0.0073 0.0177
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0013 0.0011 0.0022
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0011 0.0113
Echinococcus granulosus voltage dependent calcium channel 0.0044 0.0073 0.0177
Leishmania major hypothetical protein, conserved 0.0013 0.0011 0.0033
Giardia lamblia Kinase, CMGC CDK 0.0016 0.0016 0.0745
Leishmania major hypothetical protein, conserved 0.1589 0.323 1
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0105 0.0257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.002 0.0224
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0013 0.0011 0.0022
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Echinococcus multilocularis calcium activated potassium channel 0.0044 0.0074 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0086 0.018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0072 0.0102
Trypanosoma cruzi CYC2-like cyclin, putative 0.0009 0.0003 0.0006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.006 0.0105 0.0257
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0049 0.0084 0.0098
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0013 0.0011 0.0022
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.002 0.0043
Plasmodium falciparum protein kinase 5 0.0016 0.0016 0.0488
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.0073 0.0177
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0105 0.0257
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0044 0.0073 0.2559
Leishmania major phospholipase c-like protein 0.0061 0.0108 0.0334
Schistosoma mansoni inositol 145-trisphosphate receptor 0.2924 0.5957 0.7105
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0044 0.0073 0.0177
Loa Loa (eye worm) follicle stimulating hormone receptor 0.006 0.0105 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0003 0.0029
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0105 0.0257
Giardia lamblia NADH oxidase lateral transfer candidate 0.005 0.0086 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0044 0.0073 0.0085
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.006 0.0105 0.0257
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0044 0.0073 0.0177
Brugia malayi Cyclic-nucleotide gated cation channel 0.0049 0.0084 0.0082
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0017 0.0019 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0007 0.0076
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.005 0.0086 0.3008
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0044 0.0073 0.0177
Loa Loa (eye worm) voltage-gated calcium channel 0.0044 0.0073 0.0104
Echinococcus granulosus calcium activated potassium channel 0.0044 0.0074 0.018
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.006 0.0105 0.0123
Echinococcus multilocularis cytohesin 1 0.0113 0.0215 0.0529
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.006 0.0105 0.0257
Trypanosoma cruzi CYC2-like cyclin 4, putative 0.0009 0.0003 0.0006
Schistosoma mansoni phospholipase C beta 0.0101 0.019 0.0224
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Brugia malayi larval opioid receptor 0.006 0.0105 0.0103
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0013 0.0011 0.0023
Echinococcus multilocularis neuropeptide receptor 0.006 0.0105 0.0257
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus granulosus stromal cell derived factor 2 0.0434 0.0869 0.2155
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.005 0.0086 0.3008
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0013 0.0011 0.0285
Echinococcus multilocularis fmrfamide receptor 0.006 0.0105 0.0257
Plasmodium falciparum thioredoxin reductase 0.005 0.0086 0.3008
Schistosoma mansoni hypothetical protein 0.006 0.0105 0.0123
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0011 0.0023
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0044 0.0073 0.0177
Schistosoma mansoni inositol 145-trisphosphate receptor 0.4112 0.8384 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0013 0.0011 0.0022
Echinococcus multilocularis hyperpolarization activated cyclic 0.0049 0.0084 0.0204
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0105 0.0123
Echinococcus granulosus hyperpolarization activated cyclic 0.0049 0.0084 0.0204
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0017 0.0019 0.0573
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0011 0.0285
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0044 0.0073 0.0071
Loa Loa (eye worm) hypothetical protein 0.0077 0.014 0.0202
Trypanosoma brucei CYC2-like cyclin, putative 0.0009 0.0003 0.0006
Loa Loa (eye worm) glutathione reductase 0.0144 0.0278 0.0402
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.005 0.0086 1
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.003 0.0071
Echinococcus granulosus voltage gated hydrogen channel 1 0.0044 0.0073 0.0177
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0105 0.0151
Trichomonas vaginalis apoptosis inducing factor, putative 0.0013 0.0011 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0011 0.0116
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.2336 0.4757 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0044 0.0073 0.0177
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0014 0.0013 0.0027
Echinococcus multilocularis neuropeptide FF receptor 2 0.006 0.0105 0.0257
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0011 0.0113
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.002 0.0043
Trypanosoma brucei glycosylphosphatidylinositol-specific phospholipase C 0.0018 0.0021 0.0044
Loa Loa (eye worm) hypothetical protein 0.0187 0.0366 0.0531
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Echinococcus multilocularis cyclin dependent kinase 0.0016 0.0016 0.0035
Echinococcus granulosus tachykinin peptides receptor 99D 0.006 0.0105 0.0257
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0007 0.0006
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0044 0.0073 0.0071
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.0073 0.0177
Echinococcus multilocularis somatostatin receptor 0.006 0.0105 0.0257
Onchocerca volvulus 0.006 0.0105 0.1104
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Schistosoma mansoni hypothetical protein 0.0013 0.0011 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0105 0.0257
Echinococcus granulosus potassium large conductance calcium activated 0.0044 0.0073 0.0177
Echinococcus granulosus thioredoxin glutathione reductase 0.0144 0.0278 0.0686
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0082 0.0151 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0011 0.0116
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus granulosus neuropeptide receptor 0.006 0.0105 0.0257
Onchocerca volvulus 0.006 0.0105 0.1104
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0013 0.0011 0.0285
Echinococcus multilocularis neuropeptide s receptor 0.006 0.0105 0.0257
Echinococcus multilocularis cyclin dependent kinase 5 0.0016 0.0016 0.0035
Loa Loa (eye worm) Plcb4 protein 0.0101 0.019 0.0273
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0013 0.0011 0.0113
Onchocerca volvulus 0.006 0.0105 0.1104
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0105 0.0123
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.005 0.0086 0.018
Echinococcus granulosus neuropeptide receptor 0.006 0.0105 0.0257
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0044 0.0073 0.0085
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0105 0.0123
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.0073 0.0177
Echinococcus multilocularis cyclin dependent kinase 1 0.0016 0.0016 0.0035
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0105 0.0257
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0105 0.0257
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.0073 0.0177
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni glutamate synthase 0.0013 0.0011 0.001
Echinococcus multilocularis G-protein coupled receptor, putative 0.006 0.0105 0.0257
Onchocerca volvulus 0.006 0.0105 0.1104
Plasmodium falciparum glutathione reductase 0.0144 0.0278 1
Brugia malayi Serotonin receptor 0.006 0.0105 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0105 0.0257
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.005 0.0086 0.3008
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.006 0.0105 0.0151
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0144 0.0278 1
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Loa Loa (eye worm) voltage-gated potassium channel 0.0044 0.0073 0.0104
Loa Loa (eye worm) hypothetical protein 0.1308 0.2655 0.387
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.2336 0.4757 1
Schistosoma mansoni amine GPCR 0.006 0.0105 0.0123
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.002 0.0063
Schistosoma mansoni voltage-gated cation channel 0.0044 0.0073 0.0085
Brugia malayi phospholipase C homolog 0.0076 0.0138 0.0136
Echinococcus granulosus g protein coupled receptor 0.006 0.0105 0.0257
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.0021 0.0027
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0017 0.0019 0.0039
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0084 0.0098
Loa Loa (eye worm) programmed cell death 8 0.0013 0.0011 0.0013
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0012 0.0007 0.0008
Echinococcus multilocularis ryanodine receptor 44f 0.1538 0.3126 0.7763
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0105 0.0257
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.005 0.0086 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.006 0.0105 0.0123
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0105 0.0257
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0044 0.0073 0.0728
Brugia malayi putative neuropeptide receptor NPR1 0.006 0.0105 0.0103
Echinococcus granulosus Glutaredoxin protein 5 0.0017 0.0018 0.0039
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0044 0.0073 0.0071
Brugia malayi Dopamine receptor protein 2 0.006 0.0105 0.0103
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0105 0.0257
Loa Loa (eye worm) hypothetical protein 0.3365 0.6858 1
Trypanosoma cruzi trypanothione reductase, putative 0.0144 0.0278 0.0584
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.002 0.0043
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0086 1
Brugia malayi ion channel NompC 0.0044 0.0073 0.0071
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0044 0.0073 0.0177
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0082 0.0151 0.0371
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.003 0.0034
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0002 0.0013
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus granulosus voltage gated potassium channel 0.0044 0.0073 0.0177
Schistosoma mansoni amine GPCR 0.006 0.0105 0.0123
Trichomonas vaginalis mercuric reductase, putative 0.005 0.0086 0.0975
Loa Loa (eye worm) hypothetical protein 0.0053 0.0092 0.0131
Echinococcus multilocularis glutamate synthase 0.0013 0.0011 0.0022
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Brugia malayi p70 ribosomal S6 kinase beta 0.0026 0.0036 0.0034
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0105 0.0257
Schistosoma mansoni neuropeptide receptor 0.006 0.0105 0.0123
Loa Loa (eye worm) ryanodine receptor 0.0747 0.151 0.22
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0011 0.0023
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.006 0.0105 0.0257
Brugia malayi Thioredoxin reductase 0.0144 0.0278 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0013 0.0137
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0044 0.0073 0.0177
Echinococcus granulosus ryanodine receptor 44f 0.1538 0.3126 0.7763
Brugia malayi cation channel family protein 0.0044 0.0073 0.0071
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0011 0.0023
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0086 0.018
Echinococcus multilocularis serine threonine protein kinase 0.0012 0.0007 0.0013
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0044 0.0073 0.0177
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.005 0.0086 0.3008
Plasmodium falciparum glutathione reductase 0.005 0.0086 0.3008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0013 0.0137
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus multilocularis voltage gated potassium channel 0.0053 0.0092 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0011 0.0116
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0086 0.018
Echinococcus multilocularis nervana 2 0.0017 0.0018 0.0039
Echinococcus granulosus TRP transient receptor potential channel 0.0044 0.0073 0.0177
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.0073 0.0177
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0017 0.0019 0.0573
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.0073 0.0177
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0013 0.0011 0.0022
Echinococcus multilocularis transient receptor potential gamma protein 0.0044 0.0073 0.0177
Schistosoma mansoni disulfide oxidoreductase 0.0013 0.0011 0.001
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0007 0.0006
Brugia malayi GnHR receptor homolog 0.006 0.0105 0.0103
Onchocerca volvulus 0.0044 0.0073 0.0728
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.006 0.0105 0.0257
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0044 0.0073 0.0177
Echinococcus multilocularis g protein coupled receptor 0.006 0.0105 0.0257
Echinococcus granulosus sodium channel protein 0.0044 0.0073 0.0177
Echinococcus granulosus cyclin dependent kinase 1 0.0016 0.0016 0.0035
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.005 0.0086 0.018
Trichomonas vaginalis AGC family protein kinase 0.002 0.0024 0.0268
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.005 0.0086 0.2803
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0084 0.0098
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0101 0.019 0.0188
Loa Loa (eye worm) AGC/AKT protein kinase 0.0031 0.0048 0.0067
Echinococcus granulosus voltage dependent calcium channel 0.0044 0.0073 0.0177
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0013 0.0011 0.0023
Trichomonas vaginalis AGC family protein kinase 0.0031 0.0048 0.0539
Trichomonas vaginalis glutamate synthase, putative 0.0013 0.0011 0.0113
Schistosoma mansoni biogenic amine (dopamine) receptor 0.006 0.0105 0.0123
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.006 0.0105 0.0123
Toxoplasma gondii target of rapamycin (TOR), putative 0.0013 0.0011 0.0294
Loa Loa (eye worm) TYRA-2 protein 0.006 0.0105 0.0151
Echinococcus multilocularis shaker cognate 0.0044 0.0073 0.0177
Leishmania major trypanothione reductase 0.0144 0.0278 0.086
Leishmania major inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0163 0.0317 0.0983
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Brugia malayi phosphoinositide-dependent protein kinase I 0.002 0.0024 0.0022
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.006 0.0105 0.0151
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.0073 0.0085
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0044 0.0073 0.0177
Toxoplasma gondii hypothetical protein 0.0044 0.0073 0.2559
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0011 0.0023
Schistosoma mansoni amine GPCR 0.006 0.0105 0.0123
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.002 0.0212
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0011 0.0023
Brugia malayi neuropeptide F receptor 0.006 0.0105 0.0103
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.0073 0.0177
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0049 0.0084 0.096
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0014 0.0013 0.004
Echinococcus multilocularis ryanodine receptor 44f 0.1979 0.4026 1
Trichomonas vaginalis AGC family protein kinase 0.0031 0.0048 0.0539
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.005 0.0086 0.0208
Echinococcus granulosus serotonin receptor 0.006 0.0105 0.0257
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0058 0.0103 0.0317
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus granulosus protein kinase C gamma type 0.0012 0.0007 0.0013
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.006 0.0105 0.0257
Mycobacterium ulcerans flavoprotein disulfide reductase 0.005 0.0086 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.005 0.0086 0.3008
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0016 0.0016 0.0035
Brugia malayi AKH receptor 0.006 0.0105 0.0103
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0011 0.0009
Toxoplasma gondii transporter, cation channel family protein 0.0044 0.0073 0.2559
Schistosoma mansoni transient receptor potential channel 0.0044 0.0073 0.0085
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus multilocularis g-protein coupled receptor 0.006 0.0105 0.0257
Schistosoma mansoni voltage-gated potassium channel 0.0053 0.0092 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0105 0.0123
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0013 0.0011 0.0022
Echinococcus granulosus neuropeptide FF receptor 2 0.006 0.0105 0.0257
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0105 0.0151
Trichomonas vaginalis glutathione reductase, putative 0.005 0.0086 0.0975
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.002 0.0224
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0011 0.0023
Brugia malayi glutathione reductase 0.0144 0.0278 0.0276
Brugia malayi Variant SH3 domain containing protein 0.0052 0.0089 0.0087
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0011 0.0113
Trichomonas vaginalis AGC family protein kinase 0.0031 0.0048 0.0539
Brugia malayi Protein kinase domain containing protein 0.0016 0.0016 0.0014
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.0073 0.0085
Echinococcus multilocularis nervana 2 0.0017 0.0018 0.0039
Onchocerca volvulus 0.006 0.0105 0.1104
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0043 0.0072 0.2509
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0747 0.151 0.1799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0105 0.0123
Entamoeba histolytica protein kinase, putative 0.0026 0.0036 0.0391
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0105 0.0257
Schistosoma mansoni transient receptor potential channel 0.0044 0.0073 0.0085
Schistosoma mansoni vesicular amine transporter 0.0044 0.0073 0.0085
Echinococcus granulosus g protein coupled receptor 0.006 0.0105 0.0257
Trypanosoma cruzi CYC2-like cyclin 6, putative 0.0009 0.0003 0.0006
Trypanosoma brucei rac serine-threonine kinase, putative 0.0031 0.0048 0.01
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0002 0.0013
Loa Loa (eye worm) voltage-gated potassium channel 0.0044 0.0073 0.0104
Echinococcus multilocularis g protein coupled receptor 0.006 0.0105 0.0257
Brugia malayi Tachykinin-like peptides receptor 99D 0.006 0.0105 0.0103
Onchocerca volvulus 0.006 0.0105 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0003 0.0029
Echinococcus granulosus cyclin dependent kinase 0.0016 0.0016 0.0035
Schistosoma mansoni glutamate synthase 0.0013 0.0011 0.001
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0011 0.0113
Onchocerca volvulus 0.0434 0.0869 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0044 0.0073 0.0177
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0099 0.0185 0.0183
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus multilocularis sodium leak channel non selective protein 0.0044 0.0073 0.0177
Echinococcus granulosus peptide allatostatin:somatostatin 0.006 0.0105 0.0257
Brugia malayi cell division control protein 2 homolog 0.0016 0.0016 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.002 0.0224
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0061 0.0108 0.0227
Onchocerca volvulus 0.006 0.0105 0.1104
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.006 0.0105 0.0123
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0013 0.0011 0.0113
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.0073 0.0177
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.002 0.0043
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus multilocularis neuropeptide Y receptor 0.006 0.0105 0.0257
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.005 0.0086 0.018
Schistosoma mansoni voltage-gated potassium channel 0.0086 0.0159 0.0187
Giardia lamblia GTOR 0.0018 0.002 0.129
Plasmodium vivax protein kinase Crk2 0.0016 0.0016 0.0488
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.006 0.0105 0.0257
Echinococcus granulosus Protein kinase C brain isozyme 0.0012 0.0007 0.0013
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0037 0.0059 0.0057
Schistosoma mansoni histamine h1 receptor 0.006 0.0105 0.0123
Toxoplasma gondii transporter, cation channel family protein 0.0044 0.0073 0.2559
Echinococcus multilocularis protein kinase c epsilon type 0.0012 0.0007 0.0013
Echinococcus granulosus g-protein coupled receptor 0.006 0.0105 0.0257
Echinococcus multilocularis two pore calcium channel protein 2 0.0044 0.0073 0.0177
Brugia malayi ORL1-like opioid receptor 0.006 0.0105 0.0103
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0044 0.0073 0.0071
Plasmodium vivax glutathione reductase, putative 0.0144 0.0278 1
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0113 0.0215 0.0254
Echinococcus multilocularis neuropeptide receptor A26 0.006 0.0105 0.0257
Echinococcus granulosus neuropeptide s receptor 0.006 0.0105 0.0257
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0013 0.0011 0.0013
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0084 0.0098
Schistosoma mansoni phospholipase C beta 0.0018 0.0021 0.0022
Brugia malayi voltage-dependent calcium channel 0.0044 0.0073 0.0071
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.012
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0086 0.0265
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0016 0.0016 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0006 0.0054
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.006 0.0105 0.0151
Loa Loa (eye worm) G-protein coupled receptor 0.006 0.0105 0.0151
Onchocerca volvulus 0.006 0.0105 0.1104
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0105 0.0257
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus multilocularis transfer RNA-Gly 0.0044 0.0073 0.0177
Onchocerca volvulus 0.006 0.0105 0.1104
Onchocerca volvulus 0.0118 0.0225 0.2501
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.006 0.0105 0.0103
Echinococcus multilocularis cyclin dependent kinase 1 0.0016 0.0016 0.0035
Giardia lamblia Kinase, AGC PKA 0.0017 0.0019 0.1056
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0076 0.0138 0.0163
Loa Loa (eye worm) cytohesin 3 0.0113 0.0215 0.0311
Loa Loa (eye worm) hypothetical protein 0.0163 0.0317 0.046
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0105 0.0123
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0049 0.0084 0.0204
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.002 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0011 0.0116
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0013 0.0011 0.0009
Echinococcus granulosus fmrfamide receptor 0.006 0.0105 0.0257
Brugia malayi G-protein coupled receptor 0.006 0.0105 0.0103
Schistosoma mansoni neuropeptide F-like receptor 0.006 0.0105 0.0123
Echinococcus granulosus transient receptor potential gamma protein 0.0044 0.0073 0.0177
Plasmodium vivax thioredoxin reductase, putative 0.0144 0.0278 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0081 0.0094
Echinococcus multilocularis tachykinin peptides receptor 99D 0.006 0.0105 0.0257
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0105 0.0257
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Brugia malayi G protein-coupled receptor F59B2.13 0.006 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0105 0.0123
Echinococcus multilocularis voltage dependent calcium channel 0.0044 0.0073 0.0177
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.006 0.0105 0.1104
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0013 0.0011 0.0023
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0049 0.0084 0.012
Toxoplasma gondii hypothetical protein 0.0044 0.0073 0.2559
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0053 0.0092 0.009
Echinococcus multilocularis short transient receptor potential channel 6 0.0044 0.0073 0.0177
Onchocerca volvulus 0.006 0.0105 0.1104
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0044 0.0073 0.0177
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0043 0.0072 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0006 0.0054
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0013 0.0011 0.01
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0044 0.0073 0.0177
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0003 0.0022
Giardia lamblia Kinase, CMGC CDK 0.0016 0.0016 0.0745
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.005 0.0086 0.018
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0105 0.0257
Brugia malayi putative neuropeptide receptor 0.006 0.0105 0.0103
Onchocerca volvulus 0.006 0.0105 0.1104
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.0073 0.0085
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.002 0.0022
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0163 0.0317 0.0667
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0044 0.0073 0.0071
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0105 0.0257
Trypanosoma cruzi target of rapamycin kinase 3 0.0014 0.0013 0.0027
Schistosoma mansoni hypothetical protein 0.006 0.0105 0.0123
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0013 0.0011 0.0022
Loa Loa (eye worm) calcium channel 0.0044 0.0073 0.0104
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0016 0.0016 0.0021
Schistosoma mansoni neuropeptide receptor 0.006 0.0105 0.0123
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus multilocularis hyperpolarization activated cyclic 0.0049 0.0084 0.0204
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0105 0.0257
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0044 0.0073 0.0177
Echinococcus granulosus voltage gated potassium channel 0.0053 0.0092 0.0223
Echinococcus granulosus neuropeptide Y receptor 0.006 0.0105 0.0257
Echinococcus multilocularis potassium voltage gated channel protein 0.0044 0.0073 0.0177
Brugia malayi follicle stimulating hormone receptor 0.006 0.0105 0.0103
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.0073 0.0177
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0002 0.0013
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.006 0.0105 0.0123
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0011 0.0033
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0044 0.0073 0.0085
Trypanosoma cruzi cdc2-related kinase 3 0.0016 0.0016 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0011 0.0023
Schistosoma mansoni amine GPCR 0.006 0.0105 0.0123
Echinococcus granulosus nervana 2 0.0017 0.0018 0.0039
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0049 0.0084 0.0204
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0044 0.0073 0.0177
Schistosoma mansoni opsin-like receptor 0.006 0.0105 0.0123
Toxoplasma gondii transporter, cation channel family protein 0.0044 0.0073 0.2559
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0062 0.07
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0105 0.0257
Trypanosoma cruzi Protein kinase B 0.0023 0.003 0.0064
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0171 0.0333 0.07
Trichomonas vaginalis CMGC family protein kinase 0.0016 0.0016 0.0177
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0013 0.0011 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0007 0.0006
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.002 0.0024 0.0055
Plasmodium vivax ferrodoxin reductase, putative 0.0013 0.0011 0.0285
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.005 0.0086 0.018
Echinococcus granulosus protein kinase c epsilon type 0.0012 0.0007 0.0013
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.005 0.0086 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0017 0.0019 0.0041
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.002 0.0046
Entamoeba histolytica disulphide oxidoreductase, putative 0.0013 0.0011 0.01
Treponema pallidum NADH oxidase 0.005 0.0086 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.006 0.0105 0.0103
Leishmania major acetoin dehydrogenase e3 component-like protein 0.005 0.0086 0.0265
Echinococcus multilocularis sodium channel protein 0.0044 0.0073 0.0177
Entamoeba histolytica protein kinase, putative 0.002 0.0024 0.0255
Trichomonas vaginalis AGC family protein kinase 0.0015 0.0014 0.0149
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0011 0.001
Echinococcus granulosus two pore calcium channel protein 2 0.0044 0.0073 0.0177
Echinococcus multilocularis sex peptide receptor 0.006 0.0105 0.0257
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0105 0.0257
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.0073 0.0177
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.002 0.0063
Schistosoma mansoni hypothetical protein 0.006 0.0105 0.0123
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0013 0.0137
Echinococcus multilocularis rhodopsin orphan GPCR 0.006 0.0105 0.0257
Onchocerca volvulus 0.006 0.0105 0.1104
Echinococcus multilocularis neuropeptides capa receptor 0.006 0.0105 0.0257
Trichomonas vaginalis AGC family protein kinase 0.0031 0.0048 0.0539
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus granulosus tm gpcr rhodopsin 0.006 0.0105 0.0257
Plasmodium vivax phospholipase C-like, putative 0.0043 0.0072 0.2509
Trypanosoma brucei trypanothione reductase 0.0144 0.0278 0.0584
Echinococcus granulosus neuropeptides capa receptor 0.006 0.0105 0.0257
Schistosoma mansoni biogenic amine receptor 0.006 0.0105 0.0123
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0049 0.0084 0.012
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Schistosoma mansoni opsin-like receptor 0.006 0.0105 0.0123
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0049 0.0084 0.096
Schistosoma mansoni glutamate synthase 0.0013 0.0011 0.001
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.002 0.0024 0.0032
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0044 0.0073 0.0227
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.0062 0.07
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.006 0.0105 0.0257
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0053 0.0092 0.0223
Schistosoma mansoni two-pore calcium channel 0.0044 0.0073 0.0085
Schistosoma mansoni alpha-1 adrenergic receptor 0.006 0.0105 0.0123
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0021 0.0019
Plasmodium falciparum thioredoxin reductase 0.0144 0.0278 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0012 0.0007 0.0013
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0011 0.0285
Entamoeba histolytica protein kinase 2, putative 0.0017 0.0019 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0003 0.0029
Onchocerca volvulus 0.006 0.0105 0.1104
Loa Loa (eye worm) voltage-dependent calcium channel 0.0044 0.0073 0.0104
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.006 0.0105 0.0257
Echinococcus multilocularis potassium voltage gated channel protein 0.0044 0.0073 0.0177
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.0073 0.0085
Entamoeba histolytica protein kinase, putative 0.0031 0.0048 0.0527
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0052 0.0089 0.0127
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0044 0.0073 0.0071
Schistosoma mansoni neuropeptide receptor 0.006 0.0105 0.0123
Leishmania major hypothetical protein, conserved 0.0018 0.0021 0.0064
Onchocerca volvulus Neuropeptide F receptor homolog 0.006 0.0105 0.1104
Trichomonas vaginalis 1-phosphatidylinositol phosphodiesterase, putative 0.0018 0.0021 0.0229
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0105 0.0123
Leishmania major CYC2-like cyclin, putative 0.0009 0.0003 0.0009
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0013 0.0011 0.0285
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0084 0.0155 0.5522
Schistosoma mansoni adenoreceptor 0.006 0.0105 0.0123
Schistosoma mansoni voltage-gated ion channel 0.0044 0.0073 0.0085
Onchocerca volvulus 0.006 0.0105 0.1104
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Schistosoma mansoni sulfide quinone reductase 0.0013 0.0011 0.001
Brugia malayi phospholipase C homolog 0.0028 0.004 0.0038
Trypanosoma cruzi cdc2-related kinase 1 0.0016 0.0016 0.0034
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.006 0.0105 0.0257
Onchocerca volvulus 0.006 0.0105 0.1104
Onchocerca volvulus 0.006 0.0105 0.1104
Echinococcus multilocularis voltage gated potassium channel 0.0044 0.0073 0.0177
Schistosoma mansoni biogenic amine (5HT) receptor 0.006 0.0105 0.0123
Loa Loa (eye worm) MIR domain-containing protein 0.0434 0.0869 0.1265
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.006 0.0105 0.0257
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.005 0.0086 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0008 0.0085
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0044 0.0073 0.0154
Echinococcus granulosus thyrotropin releasing hormone receptor 0.006 0.0105 0.0257
Echinococcus granulosus short transient receptor potential channel 6 0.0044 0.0073 0.0177
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0011 0.0022
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0013 0.0011 0.01
Onchocerca volvulus 0.006 0.0105 0.1104
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0044 0.0073 0.0071
Brugia malayi hypothetical protein 0.0044 0.0073 0.0071
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Trypanosoma cruzi NADH dehydrogenase, putative 0.0013 0.0011 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0011 0.0116
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0037 0.0059 0.0057
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0049 0.0084 0.0098
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.006 0.0105 0.0123
Echinococcus granulosus biogenic amine 5HT receptor 0.006 0.0105 0.0257
Brugia malayi RE15519p 0.006 0.0105 0.0103
Echinococcus granulosus nervana 2 0.0017 0.0018 0.0039
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0043 0.0072 0.0223
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.005 0.0086 0.2803
Leishmania major dihydrolipoamide dehydrogenase, putative 0.005 0.0086 0.0265
Echinococcus granulosus potassium voltage gated channel protein 0.0044 0.0073 0.0177
Brugia malayi MIR domain containing protein 0.0434 0.0869 0.0868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0006 0.0054
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0044 0.0073 0.0071
Echinococcus granulosus hyperpolarization activated cyclic 0.0049 0.0084 0.0204
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Echinococcus multilocularis dro:myosuppressin receptor 0.006 0.0105 0.0257
Echinococcus multilocularis potassium voltage gated channel protein 0.0044 0.0073 0.0177
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0044 0.0073 0.0177
Echinococcus granulosus neuropeptide receptor A26 0.006 0.0105 0.0257
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.002 0.0212
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0013 0.0011 0.0022
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0013 0.0011 0.0285
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.005 0.0086 0.0208
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0016 0.0017
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.002 0.0027
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0049 0.0084 0.0204
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0013 0.0011 0.0113
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0049 0.0084 0.0204
Echinococcus granulosus transient receptor potential cation channel 0.0044 0.0073 0.0177
Schistosoma mansoni calcium-activated potassium channel 0.0044 0.0073 0.0085
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0105 0.0257
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0044 0.0073 0.0085
Schistosoma mansoni ryanodine receptor related 0.277 0.5642 0.6729
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0017 0.0018 0.0039
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.005 0.0086 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0016 0.0016 0.0488
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.003 0.0071
Toxoplasma gondii AGC kinase 0.0026 0.0036 0.1201
Brugia malayi Dopamine receptor protein 1 0.006 0.0105 0.0103
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0105 0.0123
Echinococcus granulosus sodium leak channel non selective protein 0.0044 0.0073 0.0177
Loa Loa (eye worm) hypothetical protein 0.0084 0.0155 0.0223
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Leishmania major hypothetical protein, unknown function 0.0044 0.0073 0.0227
Brugia malayi protein kinase C II. 0.0012 0.0007 0.0005
Trypanosoma cruzi cdc2-related kinase 3 0.0016 0.0016 0.0034
Trypanosoma cruzi cdc2-related kinase 1 0.0016 0.0016 0.0034
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.003 0.0064
Echinococcus multilocularis neuropeptide receptor 0.006 0.0105 0.0257
Schistosoma mansoni peptide (allatostatin)-like receptor 0.006 0.0105 0.0123
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0044 0.0073 0.0728
Loa Loa (eye worm) hypothetical protein 0.0044 0.0073 0.0104
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0016 0.0017
Schistosoma mansoni neuropeptide receptor 0.006 0.0105 0.0123
Entamoeba histolytica cell division protein kinase 2, putative 0.0016 0.0016 0.0165
Brugia malayi olfactory channel protein osm-9 0.0044 0.0073 0.0071
Entamoeba histolytica cell division protein kinase 2, putative 0.0016 0.0016 0.0165
Echinococcus multilocularis potassium voltage gated channel protein 0.0044 0.0073 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0005 0.0051
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0103 0.0195 0.0479
Schistosoma mansoni biogenic amine receptor 0.006 0.0105 0.0123
Echinococcus granulosus cyclin dependent kinase 5 0.0016 0.0016 0.0035
Echinococcus granulosus allatostatin A receptor 0.006 0.0105 0.0257
Echinococcus granulosus cytohesin 1 0.0113 0.0215 0.0529
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0016 0.0016 0.005
Brugia malayi Cytohesin 3 0.0113 0.0215 0.0213
Toxoplasma gondii NADPH-glutathione reductase 0.005 0.0086 0.3008
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0013
Trypanosoma brucei cdc2-related kinase 3 0.0016 0.0016 0.0034
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0026 0.0036 0.0049
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0105 0.0123
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0013 0.0137
Schistosoma mansoni rhodopsin-like orphan GPCR 0.006 0.0105 0.0123
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.003 0.0034
Echinococcus multilocularis transient receptor potential cation channel 0.0044 0.0073 0.0177
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.006 0.0105 0.0103
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0013 0.0011 0.01
Brugia malayi sulfakinin receptor protein 0.006 0.0105 0.0103
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.006 0.0105 0.0257
Echinococcus multilocularis thioredoxin glutathione reductase 0.0144 0.0278 0.0686
Onchocerca volvulus 0.0156 0.0303 0.3404
Brugia malayi hypothetical protein 0.006 0.0105 0.0103
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0003 0.0029
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0103 0.0195 0.0479
Trypanosoma cruzi inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0163 0.0317 0.0667
Loa Loa (eye worm) hypothetical protein 0.3314 0.6753 0.9848
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.006 0.0105 0.0257
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0013 0.0011 0.0033
Loa Loa (eye worm) neuropeptide F receptor 0.006 0.0105 0.0151
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.003 0.0328
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0044 0.0073 0.0177
Echinococcus granulosus hypothetical protein 0.0044 0.0073 0.0177
Schistosoma mansoni voltage-dependent calcium channel 0.0044 0.0073 0.0085
Entamoeba histolytica thioredoxin reductase, putative 0.0013 0.0011 0.01
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.0073 0.0085
Loa Loa (eye worm) ion channel NompC 0.0044 0.0073 0.0104
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0044 0.0073 0.0085
Loa Loa (eye worm) melatonin receptor type 1A 0.006 0.0105 0.0151
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0044 0.0073 0.0071
Echinococcus granulosus G protein coupled receptor 139 0.006 0.0105 0.0257
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0049 0.0084 0.0204
Trichomonas vaginalis AGC family protein kinase 0.0031 0.0048 0.0539
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0013 0.0011 0.0285
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0086 0.018
Echinococcus multilocularis fmrfamide receptor 0.006 0.0105 0.0257
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0016 0.0016 0.005
Echinococcus multilocularis biogenic amine (5HT) receptor 0.006 0.0105 0.0257
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.005 0.0086 0.2803
Schistosoma mansoni hypothetical protein 0.0044 0.0073 0.0085
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0044 0.0073 0.0071
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0049 0.0084 0.0098
Loa Loa (eye worm) ryanodine receptor 0.0044 0.0073 0.0104
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0044 0.0073 0.0085
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0013 0.0011 0.0285
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0013 0.0011 0.01
Trichomonas vaginalis AGC family protein kinase 0.0031 0.0048 0.0539
Echinococcus multilocularis two pore calcium channel protein 1 0.0044 0.0073 0.0177
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0013 0.0011 0.0022
Echinococcus granulosus 7tm_1 domain containing protein 0.006 0.0105 0.0257
Echinococcus multilocularis conserved hypothetical protein 0.0044 0.0073 0.0177
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0044 0.0073 0.0177
Loa Loa (eye worm) hypothetical protein 0.006 0.0105 0.0151
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0013 0.0011 0.0023
Echinococcus granulosus ryanodine receptor 44f 0.1979 0.4026 1
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0099 0.0185 0.0267

Activities

Activity type Activity value Assay description Source Reference
Reduction (functional) % Compound was administered at a dose of 30 mg/kg/day to evaluate the percentage reduction in plasma triglyceride(TG) after 6 days of treatment in db/db mice via oral gavage; Not significant. ChEMBL. 10411477
Reduction (functional) % Compound was administered at a dose of 30 mg/kg/day to evaluate the percentage reduction in plasma glucose(PG) after 6 days of treatment in db/db mice via oral gavage; Not significant. ChEMBL. 10411477
Reduction (functional) NA 0 % Compound was administered at a dose of 30 mg/kg/day to evaluate the percentage reduction in plasma glucose(PG) after 6 days of treatment in db/db mice via oral gavage; Not significant. ChEMBL. 10411477
Reduction (functional) NA 0 % Compound was administered at a dose of 30 mg/kg/day to evaluate the percentage reduction in plasma triglyceride(TG) after 6 days of treatment in db/db mice via oral gavage; Not significant. ChEMBL. 10411477

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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