Detailed information for compound 1430610

Basic information

Technical information
  • TDR Targets ID: 1430610
  • Name: MLS000105082
  • MW: 255.355 | Formula: C8H17NO4S2
  • H donors: 0 H acceptors: 4 LogP: -0.18 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)C1CCS(=O)(=O)C1)CC
  • InChi: 1S/C8H17NO4S2/c1-3-9(4-2)15(12,13)8-5-6-14(10,11)7-8/h8H,3-7H2,1-2H3
  • InChiKey: JCVYBNNWFCKBBI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000055011
  • Maybridge3_000568
  • IDI1_011955
  • 1,1-Dioxo-tetrahydro-1lambda*6*-thiophene-3-sulfonic acid diethylamide
  • BAS 00102286
  • ST065286

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cytochrome P450, putative 0.002 0.0271 0.0306
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0159 0.3753 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0271 0.0271
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0647 0.0647
Echinococcus multilocularis SWI:SNF matrix associated 0.0159 0.3753 0.3753
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.1192 0.1571
Onchocerca volvulus 0.0057 0.1192 0.2645
Leishmania major hypothetical protein, conserved 0.0057 0.1192 0.1571
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0892 0.2278
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0647 0.8232
Loa Loa (eye worm) CYP4Cod1 0.002 0.0271 0.0496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1158 0.1158
Trypanosoma cruzi WLM domain containing protein, putative 0.0057 0.1192 0.1571
Schistosoma mansoni rab6-interacting 0.002 0.0271 0.0224
Schistosoma mansoni cpg binding protein 0.0029 0.0496 0.045
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.1071 0.1406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1158 0.1158
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0892 0.5
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0057 0.1192 0.1571
Echinococcus granulosus Zinc finger RanBP2 type 0.0057 0.1192 0.1192
Echinococcus multilocularis 0.0011 0.0048 0.0048
Schistosoma mansoni RNA binding protein 0.0057 0.1192 0.1149
Echinococcus multilocularis zinc finger protein Ran binding 0.0057 0.1192 0.1192
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0647 0.1182
Echinococcus multilocularis SWI:SNF matrix associated 0.0159 0.3753 0.3753
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0271 0.0271
Schistosoma mansoni cpg binding protein 0.003 0.0537 0.0491
Loa Loa (eye worm) inositol-1 0.0045 0.0892 0.163
Leishmania major hypothetical protein, conserved 0.0035 0.0647 0.0823
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.13 0.1258
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0839 0.1087
Brugia malayi hypothetical protein 0.002 0.0271 0.041
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.335 0.4537
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1158 0.1158
Echinococcus granulosus ring and YY1 binding protein 0.0057 0.1192 0.1192
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0159 0.3753 1
Leishmania major hypothetical protein, conserved 0.0057 0.1192 0.1571
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0892 0.0892
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.1003 0.0959
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1158 0.2116
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0647 0.0823
Schistosoma mansoni hypothetical protein 0.0159 0.3753 0.3722
Schistosoma mansoni zinc finger protein 0.0057 0.1192 0.1149
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0647 0.108
Brugia malayi beta-lactamase 0.0035 0.0647 0.1104
Schistosoma mansoni hypothetical protein 0.0159 0.3753 0.3722
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0647 0.0823
Loa Loa (eye worm) hypothetical protein 0.0035 0.0647 0.1182
Loa Loa (eye worm) hypothetical protein 0.0057 0.1192 0.2178
Schistosoma mansoni inositol monophosphatase 0.0045 0.0892 0.0848
Onchocerca volvulus 0.0035 0.0647 0.108
Plasmodium vivax hypothetical protein, conserved 0.0159 0.3753 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.335 0.4537
Loa Loa (eye worm) hypothetical protein 0.0035 0.0647 0.1182
Mycobacterium ulcerans beta-lactamase 0.0035 0.0647 0.1616
Onchocerca volvulus 0.0035 0.0647 0.108
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.1192 0.1571
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0775 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.7326 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0271 0.0602
Echinococcus multilocularis RUN 0.002 0.0271 0.0271
Mycobacterium tuberculosis Conserved protein 0.0035 0.0647 0.1134
Brugia malayi Cytochrome P450 family protein 0.002 0.0271 0.0411
Leishmania major hypothetical protein, conserved 0.0057 0.1192 0.1571
Brugia malayi YY1-associated factor 2 0.0057 0.1192 0.2108
Brugia malayi SWIB/MDM2 domain containing protein 0.0159 0.3753 0.6829
Schistosoma mansoni brg-1 associated factor 0.0159 0.3753 0.3722
Mycobacterium ulcerans hypothetical protein 0.0035 0.0647 0.1616
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0839 0.1087
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.7326 1
Echinococcus granulosus RUN 0.002 0.0271 0.0271
Mycobacterium leprae Probable lipase LipE 0.0035 0.0647 0.8232
Mycobacterium tuberculosis Conserved protein 0.0035 0.0647 0.1134
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0775 0.1377
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0647 0.1134
Loa Loa (eye worm) hypothetical protein 0.0049 0.1003 0.1832
Toxoplasma gondii ran binding protein 0.0057 0.1192 0.3087
Schistosoma mansoni TRABID protein (C64 family) 0.0057 0.1192 0.1149
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0647 0.1134
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.2725 0.2725
Brugia malayi follicle stimulating hormone receptor 0.0228 0.5473 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0647 0.1134
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1138 0.2941
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0647 0.1134
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0271 0.0271
Trypanosoma cruzi WLM domain containing protein, putative 0.0057 0.1192 0.1571
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.1192 0.1571
Echinococcus multilocularis SWI:SNF matrix associated 0.0159 0.3753 0.3753
Echinococcus granulosus cpg binding protein 0.003 0.0537 0.0537
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0159 0.3753 0.3753
Leishmania major hypothetical protein, conserved 0.0057 0.1192 0.1571
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0892 0.116
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0271 0.0271
Echinococcus granulosus tumor protein p63 0.0335 0.8145 0.8145
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0057 0.1192 0.1571
Loa Loa (eye worm) hypothetical protein 0.002 0.0271 0.0495
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0496 0.0906
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.1192 0.1571
Loa Loa (eye worm) hypothetical protein 0.0057 0.1192 0.2178
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0048 0.0048
Toxoplasma gondii hypothetical protein 0.0049 0.0995 0.2557
Schistosoma mansoni lipoxygenase 0.0118 0.2725 0.269
Loa Loa (eye worm) cytochrome P450 0.0011 0.0048 0.0088
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0647 0.1134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1158 0.1158
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0892 0.2278
Chlamydia trachomatis SWIB complex protein 0.0159 0.3753 0.5
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0159 0.3753 1
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0271 0.0306
Brugia malayi beta-lactamase family protein 0.0035 0.0647 0.1104
Loa Loa (eye worm) hypothetical protein 0.0035 0.0647 0.1182
Schistosoma mansoni cpg binding protein 0.003 0.0537 0.0491
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0271 0.0306
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0057 0.1192 0.1192
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1158 0.1115
Onchocerca volvulus 0.0035 0.0647 0.108
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0159 0.3753 1
Schistosoma mansoni hypothetical protein 0.0057 0.1192 0.1149
Mycobacterium ulcerans hypothetical protein 0.0159 0.3754 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.2725 0.2725
Schistosoma mansoni polycystin 1-related 0.002 0.0271 0.0224
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0057 0.1192 0.1571
Brugia malayi brahma associated protein 60 kDa 0.0159 0.3753 0.6829
Chlamydia trachomatis DNA topoisomerase I 0.0159 0.3753 0.5
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Leishmania major hypothetical protein, conserved 0.0057 0.1192 0.1571
Mycobacterium ulcerans lipase LipD 0.0035 0.0647 0.1616
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0647 0.0602
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0647 0.1104
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0057 0.1192 0.2108
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0839 0.1087
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0647 0.1616
Onchocerca volvulus 0.0049 0.1003 0.2102
Onchocerca volvulus 0.0029 0.0496 0.0646
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.3754 0.7016
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0271 0.0271
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0057 0.1192 0.1192
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0647 0.0647
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0057 0.1192 0.1571
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0892 0.079
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0647 0.0602
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0647 0.1616
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0892 0.079
Trypanosoma brucei hypothetical protein, conserved 0.0057 0.1192 0.1571
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0057 0.1192 0.1571
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0057 0.1192 0.1571
Loa Loa (eye worm) cytochrome P450 family protein 0.005 0.102 0.1863
Echinococcus multilocularis dnaJ subfamily B 0.0409 1 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0892 0.5
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0159 0.3753 1
Brugia malayi beta-lactamase family protein 0.0035 0.0647 0.1104
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0839 0.1087
Loa Loa (eye worm) hypothetical protein 0.002 0.0271 0.0495
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0057 0.1192 0.2108
Schistosoma mansoni loxhd1 0.002 0.0271 0.0224
Leishmania major cytochrome p450-like protein 0.002 0.0271 0.0306
Schistosoma mansoni hypothetical protein 0.002 0.0271 0.0224
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0892 0.116
Onchocerca volvulus 0.0159 0.3753 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0892 0.116
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0647 0.1134
Schistosoma mansoni lipoxygenase 0.0082 0.1838 0.1799
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0647 0.0823
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.7326 1
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0271 0.0496
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1158 0.2046
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0057 0.1192 0.2645
Schistosoma mansoni rab6-interacting 0.002 0.0271 0.0224
Loa Loa (eye worm) hypothetical protein 0.0035 0.0647 0.1182
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1158 0.1115
Trichomonas vaginalis conserved hypothetical protein 0.0159 0.3753 1
Brugia malayi Cytochrome P450 family protein 0.002 0.0271 0.0411
Schistosoma mansoni inositol monophosphatase 0.0045 0.0892 0.0848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1158 0.1115
Onchocerca volvulus 0.0057 0.1192 0.2645
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0647 0.1134
Loa Loa (eye worm) doublecortin family protein 0.002 0.0271 0.0495
Toxoplasma gondii ABC1 family protein 0.0035 0.0647 0.1616
Loa Loa (eye worm) brahma associated protein 0.0159 0.3753 0.6857
Echinococcus multilocularis tumor protein p63 0.0335 0.8145 0.8145
Loa Loa (eye worm) hypothetical protein 0.0057 0.1192 0.2178
Echinococcus multilocularis ring and YY1 binding protein 0.0057 0.1192 0.1192
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0057 0.1192 0.2645
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0057 0.1192 0.1571
Brugia malayi hypothetical protein 0.002 0.0271 0.041
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0159 0.3753 0.3753
Brugia malayi Cytochrome P450 family protein 0.005 0.102 0.1791
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0271 0.0271
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0057 0.1192 0.1192
Brugia malayi CXXC zinc finger family protein 0.0029 0.0496 0.0825
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0892 0.079
Loa Loa (eye worm) hypothetical protein 0.0057 0.1192 0.2178
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0892 0.116
Schistosoma mansoni hypothetical protein 0.0159 0.3753 0.3722
Onchocerca volvulus 0.0057 0.1192 0.2645
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0159 0.3753 0.6857
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.7326 1
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0892 0.0892
Brugia malayi Inositol-1 0.0045 0.0892 0.1556
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0271 0.0496
Schistosoma mansoni hypothetical protein 0.0409 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.5473 1
Echinococcus granulosus zinc finger protein Ran binding 0.0057 0.1192 0.1192
Onchocerca volvulus 0.0057 0.1192 0.2645
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0057 0.1192 0.3087
Echinococcus multilocularis cpg binding protein 0.003 0.0537 0.0537
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.5329 1
Schistosoma mansoni fusion 0.0057 0.1192 0.1149
Loa Loa (eye worm) hypothetical protein 0.0057 0.1192 0.2178
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0057 0.1192 0.2108
Loa Loa (eye worm) beta-lactamase 0.0035 0.0647 0.1182
Brugia malayi Doublecortin family protein 0.002 0.0271 0.041
Loa Loa (eye worm) hypothetical protein 0.0035 0.0647 0.1182
Loa Loa (eye worm) hypothetical protein 0.0035 0.0647 0.1182
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0057 0.1192 0.2108
Echinococcus granulosus SWI:SNF matrix associated 0.0159 0.3753 0.3753
Brugia malayi brahma associated protein 60 kDa 0.0159 0.3753 0.6829
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.335 0.4537
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0647 0.1134

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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