Detailed information for compound 1430746

Basic information

Technical information
  • TDR Targets ID: 1430746
  • Name: 2-[methyl-[(2-methylphenyl)methyl]amino]-N-[2 -(phenoxy)phenyl]acetamide
  • MW: 360.449 | Formula: C23H24N2O2
  • H donors: 1 H acceptors: 1 LogP: 4.55 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1Oc1ccccc1)CN(Cc1ccccc1C)C
  • InChi: 1S/C23H24N2O2/c1-18-10-6-7-11-19(18)16-25(2)17-23(26)24-21-14-8-9-15-22(21)27-20-12-4-3-5-13-20/h3-15H,16-17H2,1-2H3,(H,24,26)
  • InChiKey: NVSCOFLDQQZRNN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[methyl-(2-methylbenzyl)amino]-N-[2-(phenoxy)phenyl]acetamide
  • 2-[methyl-[(2-methylphenyl)methyl]amino]-N-[2-(phenoxy)phenyl]ethanamide
  • MLS000335566
  • SMR000253320
  • T5246129

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 4 Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0466 0.0505
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0296 0.4254
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0177 0.0197
Onchocerca volvulus 0.0287 0.2964 0.2953
Brugia malayi beta-lactamase family protein 0.0035 0.0177 0.0203
Brugia malayi PHD-finger family protein 0.0035 0.0176 0.0202
Echinococcus granulosus jumonji domain containing 1A 0.0037 0.0194 0.0217
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1354 0.1516
Brugia malayi F/Y-rich N-terminus family protein 0.0045 0.0289 0.0346
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0199 0.0223
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0831 0.093
Schistosoma mansoni phd finger protein 0.0042 0.0255 0.0267
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0177 0.0203
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0176 0.1912
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0083
Schistosoma mansoni cpg binding protein 0.0076 0.063 0.0688
Loa Loa (eye worm) RNA binding protein 0.0061 0.0466 0.0718
Toxoplasma gondii hypothetical protein 0.0025 0.0058 0.0326
Echinococcus multilocularis snurportin 1 0.0607 0.6499 0.7275
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0194 0.0298
Echinococcus multilocularis liprin alpha 2 0.0024 0.0054 0.006
Brugia malayi Shank2E 0.0024 0.0054 0.0047
Mycobacterium tuberculosis Hypothetical protein 0.0734 0.7905 1
Schistosoma mansoni chromobox protein 0.0189 0.1875 0.2084
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.0668 0.0731
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.0668 0.0826
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0092 0.0802 0.0898
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0211 0.2117 0.237
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0176 0.0197
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0061 0.0465 0.3949
Echinococcus multilocularis jumonji domain containing 1A 0.0037 0.0194 0.0217
Schistosoma mansoni jumonji/arid domain-containing protein 0.0206 0.2066 0.2299
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0021 0.0024
Echinococcus multilocularis phd:f box containing protein 0.0037 0.0194 0.0217
Schistosoma mansoni myst-related protein 0.0022 0.0027 0.0012
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.0668 0.1028
Onchocerca volvulus Tankyrase homolog 0.0024 0.0054 0.0037
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0429 0.066
Echinococcus multilocularis polycomb protein SCMH1 0.0255 0.2602 0.2913
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0048 0.0321 0.0342
Echinococcus multilocularis Sterile alpha motif SAM 0.0024 0.0054 0.006
Echinococcus multilocularis cpg binding protein 0.0076 0.063 0.0705
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0024 0.0054 0.0041
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0199 0.0223
Echinococcus multilocularis peregrin 0.0035 0.0176 0.0197
Brugia malayi mbt repeat family protein 0.0265 0.2716 0.3423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1354 0.1501
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0024 0.0054 0.0505
Mycobacterium tuberculosis Conserved hypothetical protein 0.0734 0.7905 1
Giardia lamblia PHD finger protein 15 0.0035 0.0176 0.0196
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0369 0.3864 0.4316
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0272
Loa Loa (eye worm) AIDA-1b 0.0024 0.0054 0.0083
Schistosoma mansoni cpg binding protein 0.0076 0.063 0.0688
Loa Loa (eye worm) hypothetical protein 0.003 0.0115 0.0177
Trichomonas vaginalis esterase, putative 0.0035 0.0177 0.0197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0054 0.0042
Echinococcus multilocularis Sterile alpha motif type 0.0024 0.0054 0.006
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2198 0.2185
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0024 0.0054 0.0042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.258 0.3971
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0466 0.057
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0831 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1144 0.1252
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.0668 1
Trichomonas vaginalis cgi-62, putative 0.0024 0.0054 0.0041
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.1144 1
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0042
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1163 0.1286
Onchocerca volvulus 0.0048 0.0321 0.0305
Schistosoma mansoni phosphatidylserine receptor 0.0037 0.0194 0.0199
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0272
Schistosoma mansoni polyhomeotic 0.0024 0.0054 0.0042
Brugia malayi beta-lactamase family protein 0.0035 0.0177 0.0203
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0177 0.2401
Onchocerca volvulus 0.0024 0.0054 0.0037
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0177 0.0272
Loa Loa (eye worm) hypothetical protein 0.0094 0.0831 0.1279
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0471 0.0528
Brugia malayi RNA binding protein 0.0061 0.0466 0.057
Echinococcus granulosus SAM and MBT domain containing protein 0.0369 0.3864 0.4326
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0083
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.1144 0.1252
Plasmodium vivax JmjC domain containing protein 0.0058 0.043 0.5047
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0177 0.018
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0211 0.2117 0.237
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0024 0.0054 0.006
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0037 0.0194 0.0199
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0831 0.0847
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0471 0.0419
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0298
Brugia malayi jmjC domain containing protein 0.0248 0.2531 0.3188
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.0668 0.5762
Schistosoma mansoni sex comb on midleg homolog 0.0255 0.2602 0.29
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0176 0.1379
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0831 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0177 0.0198
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0314 0.3254 0.3643
Schistosoma mansoni hypothetical protein 0.0035 0.0176 0.0179
Echinococcus granulosus importin subunit beta 1 0.0057 0.0415 0.0465
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0024 0.0054 0.0041
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0047 0.0309 0.2558
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0037 0.0194 0.1536
Loa Loa (eye worm) hypothetical protein 0.0037 0.0199 0.0307
Brugia malayi hypothetical protein 0.0024 0.0054 0.0047
Schistosoma mansoni DNAj-like protein 0.0024 0.0054 0.0042
Plasmodium vivax protein kinase, putative 0.0024 0.0054 0.0403
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0466 0.0718
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0415 0.6092
Onchocerca volvulus 0.0024 0.0054 0.0037
Loa Loa (eye worm) hypothetical protein 0.0057 0.0415 0.0639
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0466 0.0505
Brugia malayi Pre-SET motif family protein 0.0037 0.0199 0.0232
Leishmania major importin beta-1 subunit, putative 0.0046 0.0296 0.2451
Brugia malayi bicaudal-C 0.0024 0.0054 0.0047
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0831 1
Plasmodium vivax SET domain protein, putative 0.0037 0.0199 0.2201
Echinococcus granulosus geminin 0.0177 0.1744 0.1952
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0471 0.0381
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0296 0.0349
Loa Loa (eye worm) mbt repeat family protein 0.0265 0.2716 0.418
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0314 0.3254 0.3643
Echinococcus granulosus liprin alpha 2 0.0024 0.0054 0.006
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0033
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0177 0.0197
Brugia malayi coiled-coil like protein 1 0.0024 0.0054 0.0047
Schistosoma mansoni hypothetical protein 0.0822 0.8873 0.9934
Schistosoma mansoni hypothetical protein 0.0827 0.8932 1
Schistosoma mansoni ran 0.0021 0.0021 0.0005
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0415 0.6092
Brugia malayi N-terminal motif family protein 0.0218 0.2198 0.2765
Plasmodium falciparum phd finger protein, putative 0.0035 0.0176 0.1912
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0831 1
Schistosoma mansoni hypothetical protein 0.0177 0.1744 0.1938
Echinococcus granulosus tar DNA binding protein 0.0061 0.0466 0.0522
Schistosoma mansoni protein phosphatase 2C 0.0037 0.0194 0.0199
Loa Loa (eye worm) CHromoDomain protein family member 0.0029 0.011 0.0169
Brugia malayi Pre-SET motif family protein 0.0253 0.258 0.325
Echinococcus multilocularis lysine specific demethylase 6a 0.0037 0.0194 0.0217
Leishmania major hypothetical protein, conserved 0.0035 0.0177 0.1384
Onchocerca volvulus 0.0058 0.0429 0.0413
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0831 0.0847
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0054 0.0042
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0176 0.0197
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1354 0.1516
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0024 0.0054 0.0505
Echinococcus multilocularis dnaJ subfamily B 0.0827 0.8932 1
Schistosoma mansoni hypothetical protein 0.0177 0.1744 0.1938
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0171 0.0191
Echinococcus multilocularis SAM and MBT domain containing protein 0.0369 0.3864 0.4326
Echinococcus granulosus transcription factor Dp 1 0.0046 0.0297 0.0333
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0024 0.0054 0.006
Mycobacterium leprae Probable lipase LipE 0.0035 0.0177 0.0039
Onchocerca volvulus 0.0024 0.0054 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.1354 0.1696
Schistosoma mansoni Protein aveugle 0.0024 0.0054 0.0042
Brugia malayi CXXC zinc finger family protein 0.0058 0.0429 0.0523
Brugia malayi AIDA-1b 0.0024 0.0054 0.0047
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0668 1
Echinococcus granulosus cpg binding protein 0.0076 0.063 0.0705
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.0668 0.0748
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0466 0.0505
Echinococcus granulosus histone acetyltransferase myst3 0.0042 0.0255 0.0285
Echinococcus granulosus Transglutaminase 0.0734 0.7905 0.8849
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0147 0.1548
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0147 0.1548
Loa Loa (eye worm) MBCTL1 0.0092 0.0802 0.1234
Schistosoma mansoni lip-related protein (liprin) alpha 0.0024 0.0054 0.0042
Onchocerca volvulus 0.0035 0.0177 0.016
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0415 0.0465
Echinococcus granulosus phd:f box containing protein 0.0037 0.0194 0.0217
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0024 0.0054 0.006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0177 0.0198
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0668 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0092 0.0802 0.0881
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0083
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.0668 0.0748
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0296 0.0349
Mycobacterium tuberculosis Long conserved protein 0.0734 0.7905 1
Toxoplasma gondii hypothetical protein 0.0033 0.0147 0.1116
Trichomonas vaginalis set domain proteins, putative 0.0287 0.2964 0.3733
Schistosoma mansoni jumonji domain containing protein 0.0187 0.1855 0.2062
Schistosoma mansoni hypothetical protein 0.0734 0.7905 0.8847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1354 0.1501
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1144 0.1265
Brugia malayi CHD4 protein 0.0029 0.011 0.0118
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0471 0.0381
Brugia malayi beta-lactamase 0.0035 0.0177 0.0203
Mycobacterium ulcerans transglutaminase family protein 0.0734 0.7905 1
Brugia malayi jmjC domain containing protein 0.0037 0.0194 0.0225
Brugia malayi PHD-finger family protein 0.003 0.0115 0.0125
Brugia malayi Thioredoxin family protein 0.0734 0.7905 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.2198 0.3382
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0415 0.351
Entamoeba histolytica hypothetical protein 0.0046 0.0296 0.4254
Loa Loa (eye worm) hypothetical protein 0.0037 0.0194 0.0298
Schistosoma mansoni jumonji/arid domain-containing protein 0.0206 0.2066 0.2299
Schistosoma mansoni hypothetical protein 0.0314 0.3254 0.3631
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0083
Onchocerca volvulus 0.0035 0.0177 0.016
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0177 0.2401
Echinococcus multilocularis geminin 0.0177 0.1744 0.1952
Brugia malayi Sphingomyelin synthase-related 1 0.0024 0.0054 0.0047
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0024 0.0054 0.006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0271
Trypanosoma cruzi Kinesin-13 5, putative 0.0024 0.0054 0.0505
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.0297 0.0333
Plasmodium falciparum importin beta, putative 0.0057 0.0415 0.4867
Brugia malayi jmjC domain containing protein 0.0037 0.0194 0.0225
Echinococcus granulosus liprin alpha 2 0.0024 0.0054 0.006
Echinococcus granulosus snurportin 1 0.0607 0.6499 0.7275
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.1354 0.2084
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0029 0.011 0.0123
Echinococcus granulosus pdz domain containing protein 0.0024 0.0054 0.006
Brugia malayi Bromodomain containing protein 0.0035 0.0176 0.0202
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0272
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0024 0.0054 0.0083
Onchocerca volvulus 0.0035 0.0177 0.016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0199 0.0205
Brugia malayi hypothetical protein 0.0024 0.0054 0.0047
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0021 0.0006
Echinococcus multilocularis chromobox protein 2 0.0189 0.1875 0.2099
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0177 0.2401
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0466 0.0505
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0054 0.0042
Leishmania major hypothetical protein, conserved 0.0037 0.0194 0.1536
Mycobacterium tuberculosis Conserved hypothetical protein 0.0734 0.7905 1
Schistosoma mansoni Protein aveugle 0.0024 0.0054 0.0042
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0177 0.1919
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0591 0.0909
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0083
Onchocerca volvulus 0.0024 0.0054 0.0037
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0499 0.531 0.5944
Echinococcus granulosus peregrin 0.0035 0.0176 0.0197
Mycobacterium ulcerans hypothetical protein 0.0734 0.7905 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0831 0.093
Brugia malayi RNA, U transporter 1 0.0162 0.1575 0.1975
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0831 0.7211
Onchocerca volvulus 0.0024 0.0054 0.0037
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0037 0.0194 0.2665
Giardia lamblia Transglutaminase/protease, putative 0.0734 0.7905 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0199 0.0223
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0831 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0466 0.0505
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0831 0.5
Echinococcus multilocularis liprin alpha 2 0.0024 0.0054 0.006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.1144 0.1281
Loa Loa (eye worm) hypothetical protein 0.0086 0.0736 0.1132
Brugia malayi jmjC domain containing protein 0.0037 0.0194 0.0225
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0092 0.0802 0.0996
Mycobacterium ulcerans hypothetical protein 0.0734 0.7905 1
Toxoplasma gondii PLU-1 family protein 0.0042 0.0252 0.2057
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0329 0.0368
Brugia malayi cask-interacting protein 2 0.0024 0.0054 0.0047
Schistosoma mansoni phd/f-box containing protein 0.0037 0.0194 0.0199
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0083
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0037 0.0194 0.2665
Echinococcus granulosus sphingomyelin synthase protein 1 0.0024 0.0054 0.006
Echinococcus multilocularis histone acetyltransferase myst3 0.0042 0.0255 0.0285
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.1018 0.8874
Schistosoma mansoni spingomyelin synthetase-related 0.0024 0.0054 0.0042
Echinococcus multilocularis JmjC domain containing protein 4 0.0037 0.0194 0.0217
Echinococcus multilocularis histone acetyltransferase MYST2 0.0092 0.0802 0.0898
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0054 0.0042
Onchocerca volvulus 0.0289 0.2984 0.2972
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0054 0.0042
Trypanosoma cruzi hypothetical protein 0.0024 0.0054 0.0505
Schistosoma mansoni hypothetical protein 0.0024 0.0054 0.0042
Echinococcus granulosus Sterile alpha motif type 0.0024 0.0054 0.006
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0024 0.0054 0.0047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0054 0.0042
Onchocerca volvulus Alhambra homolog 0.0035 0.0176 0.016
Schistosoma mansoni importin beta-1 0.0057 0.0415 0.0447
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1144 0.1252
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0024 0.0054 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.1354 0.1516
Trichomonas vaginalis peptide N-glycanase, putative 0.0734 0.7905 1
Loa Loa (eye worm) hypothetical protein 0.0438 0.463 0.7125
Brugia malayi jmjC domain containing protein 0.0211 0.2117 0.2663
Loa Loa (eye worm) beta-lactamase 0.0035 0.0177 0.0272
Giardia lamblia Hypothetical protein 0.0734 0.7905 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0029 0.011 0.0123
Echinococcus granulosus lysine specific demethylase 6a 0.0037 0.0194 0.0217
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0176 0.1379
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0021 0.0024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.8568 0.9592
Loa Loa (eye worm) tnks protein 0.0024 0.0054 0.0083
Brugia malayi mbt repeat family protein 0.0438 0.463 0.5849
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0037 0.0194 0.2665
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0466 0.0522
Echinococcus multilocularis polyhomeotic protein 2 0.0024 0.0054 0.006
Schistosoma mansoni ran 0.0021 0.0021 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0177 0.018
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0831 0.7211
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0029 0.011 0.0104
Brugia malayi TAR-binding protein 0.0061 0.0466 0.057
Plasmodium vivax importin-beta 2, putative 0.0057 0.0415 0.4867
Echinococcus granulosus dnaJ subfamily B 0.0827 0.8932 1
Trypanosoma cruzi Kinesin-13 5, putative 0.0024 0.0054 0.0505
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.1144 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1144 0.1252
Giardia lamblia Kinesin-13 0.0024 0.0054 0.0041
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0143 0.1367 0.1531
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.1354 0.1516
Mycobacterium leprae Conserved hypothetical protein 0.0734 0.7905 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0177 0.0197
Echinococcus multilocularis lysine specific demethylase 5A 0.0188 0.1865 0.2088
Plasmodium falciparum zinc finger protein, putative 0.0022 0.0027 0.0071
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0466 0.0718
Onchocerca volvulus 0.0024 0.0054 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1144 0.1265
Echinococcus granulosus histone acetyltransferase MYST2 0.0092 0.0802 0.0898
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0199 0.0205
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.0668 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0054 0.0042
Mycobacterium ulcerans putative transglutaminase-like protein 0.0734 0.7905 1
Brugia malayi Probable ClpP-like protease 0.0094 0.0831 0.1033
Brugia malayi Importin beta-1 subunit 0.0057 0.0415 0.0506
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0177 0.0197
Echinococcus multilocularis Transglutaminase 0.0734 0.7905 0.8849
Toxoplasma gondii ABC1 family protein 0.0035 0.0177 0.1384
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0272
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0199 0.0205
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0471 0.0528
Brugia malayi jmjC domain containing protein 0.0037 0.0194 0.0225
Loa Loa (eye worm) hypothetical protein 0.0092 0.0802 0.1234
Loa Loa (eye worm) jmjC domain-containing protein 0.0248 0.2531 0.3895
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0194 0.0298
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0143 0.1367 0.1531
Entamoeba histolytica hypothetical protein 0.0022 0.0027 0.0089
Echinococcus granulosus chromobox protein 2 0.0189 0.1875 0.2099
Echinococcus granulosus polycomb protein SCMH1 0.0255 0.2602 0.2913
Brugia malayi Liprin-alpha 2 0.0024 0.0054 0.0047
Echinococcus granulosus JmjC domain containing protein 4 0.0037 0.0194 0.0217
Plasmodium falciparum JmjC domain-containing protein, putative 0.0058 0.043 0.5047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0054 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0177 0.0197
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0177 0.0039
Schistosoma mansoni hypothetical protein 0.0607 0.6499 0.727
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0054 0.0041
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0092 0.0802 0.0898
Schistosoma mansoni sex comb on midleg homolog 0.0255 0.2602 0.29
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0438 0.463 0.4622
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0194 0.0298
Echinococcus granulosus polyhomeotic protein 2 0.0024 0.0054 0.006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.1144 0.1281
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0272
Schistosoma mansoni cpg binding protein 0.0058 0.0429 0.0463
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0296 0.0349
Loa Loa (eye worm) hypothetical protein 0.0035 0.0177 0.0272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.1354 0.1501
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0088 0.008
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0831 0.5
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0607 0.6499 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0176 0.0179
Echinococcus granulosus lysine specific demethylase 5A 0.0206 0.2066 0.2313
Loa Loa (eye worm) hypothetical protein 0.0024 0.0054 0.0083
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2278 0.2719
Echinococcus granulosus Sterile alpha motif SAM 0.0024 0.0054 0.006
Schistosoma mansoni myst-related protein 0.0022 0.0027 0.0012
Mycobacterium tuberculosis Conserved protein 0.0734 0.7905 1
Schistosoma mansoni jumonji domain containing protein 0.0037 0.0194 0.0199
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0831 0.0914
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0329 0.0368
Echinococcus multilocularis pdz domain containing protein 0.0024 0.0054 0.006
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0176 0.0271
Mycobacterium leprae Conserved hypothetical protein 0.0734 0.7905 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0499 0.531 0.5944

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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