Detailed information for compound 1431468

Basic information

Technical information
  • TDR Targets ID: 1431468
  • Name: Oprea1_860251
  • MW: 387.476 | Formula: C18H17N3O3S2
  • H donors: 1 H acceptors: 2 LogP: 2.99 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1c(SCC(=O)N)nc2c(c1=O)c1CCCc1s2
  • InChi: 1S/C18H17N3O3S2/c1-24-11-7-5-10(6-8-11)21-17(23)15-12-3-2-4-13(12)26-16(15)20-18(21)25-9-14(19)22/h5-8H,2-4,9H2,1H3,(H2,19,22)
  • InChiKey: SVZFJEZAAXBGLD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ChemDiv1_006074
  • MLS000687612
  • SMR000283388
  • BAS 02287520
  • ZINC00755319
  • STOCK1S-89060
  • Oprea1_765214

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ran, putative 0.0026 0.0067 0.0418
Echinococcus granulosus importin subunit beta 1 0.0035 0.012 0.0264
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0864 0.6328
Echinococcus multilocularis 0.0123 0.0629 0.1385
Echinococcus granulosus geminin 0.0169 0.0893 0.1965
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.006 0.0137
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0058 0.0353
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Echinococcus granulosus snurportin 1 0.0372 0.206 0.4534
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0019 0.0064
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0024 0.0804
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0281 0.0619
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0024 0.0105
Toxoplasma gondii target of rapamycin (TOR), putative 0.0017 0.002 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0723 0.1591
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0017 0.002 0.016
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0123 0.0629 0.1385
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.0534 0.8207
Echinococcus multilocularis cpg binding protein 0.006 0.0263 0.0578
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0402 0.8269
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0608 0.1338
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.002 0.0044
Brugia malayi MH2 domain containing protein 0.0119 0.0605 0.4413
Loa Loa (eye worm) hypothetical protein 0.0123 0.0629 0.302
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.002 0.0572
Schistosoma mansoni hypothetical protein 0.0047 0.0188 0.0414
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0161 0.0354
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.006 0.08
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.002 0.0048
Schistosoma mansoni ap endonuclease 0.0018 0.0024 0.0053
Leishmania major GTP-binding protein, putative 0.0026 0.0067 0.0918
Leishmania major hypothetical protein, conserved 0.0024 0.006 0.08
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.002 0.016
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0588 0.0622
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0281 0.1322
Schistosoma mansoni cpg binding protein 0.006 0.0263 0.0578
Schistosoma mansoni hypothetical protein 0.0169 0.0893 0.1965
Echinococcus granulosus insulin receptor 0.0054 0.0233 0.0513
Loa Loa (eye worm) hypothetical protein 0.0123 0.0629 0.302
Giardia lamblia GTOR 0.0017 0.002 0.1654
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0123 0.0629 0.1385
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0067 0.3291
Trypanosoma cruzi target of rapamycin kinase 3 0.0017 0.002 0.016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.052 0.055
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0281 0.0619
Plasmodium falciparum glutathione reductase 0.0046 0.0183 0.0477
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0179 0.0824
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0723 0.1591
Schistosoma mansoni tyrosine kinase 0.0091 0.0441 0.0971
Schistosoma mansoni tyrosine kinase 0.0054 0.0233 0.0513
Brugia malayi glutathione reductase 0.0046 0.0183 0.1283
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0024 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0864 0.6328
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0183 0.0402
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0038 0.0454
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0067 0.0918
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0123 0.0629 0.1385
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.012 0.0536
Leishmania major trypanothione reductase 0.0046 0.0183 0.2791
Mycobacterium tuberculosis Probable reductase 0.0104 0.052 0.055
Loa Loa (eye worm) glutathione reductase 0.0046 0.0183 0.0843
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.006 0.0775
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0024 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0281 0.0619
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0011 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Schistosoma mansoni cpg binding protein 0.006 0.0263 0.0578
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0915 0.6706
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0024 0.0224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0011 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0179 0.0394
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.1359 1
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0402 0.8269
Schistosoma mansoni tyrosine kinase 0.0092 0.0447 0.0983
Mycobacterium ulcerans monoamine oxidase 0.0123 0.0629 0.0619
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0011 0.0001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0011 0.0009
Schistosoma mansoni amine oxidase 0.0123 0.0629 0.1385
Echinococcus granulosus epidermal growth factor receptor 0.0092 0.0447 0.0983
Schistosoma mansoni tyrosine kinase 0.0054 0.0233 0.0513
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0058 0.0743
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0011 0.0033
Plasmodium vivax hypothetical protein, conserved 0.0123 0.0629 0.1709
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.012 0.1719
Schistosoma mansoni hypothetical protein 0.004 0.0152 0.0334
Plasmodium falciparum thioredoxin reductase 0.0016 0.0011 0.0002
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0011 0.0009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.0768 0.3698
Loa Loa (eye worm) hypothetical protein 0.0051 0.0215 0.0999
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0402 0.8269
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0188 0.0867
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0017 0.002 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Brugia malayi RNA binding protein 0.0063 0.0281 0.2011
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0011 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0024 0.0224
Plasmodium falciparum importin beta, putative 0.0035 0.012 0.0303
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.0768 0.5623
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0067 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.052 0.055
Echinococcus multilocularis insulin receptor 0.0054 0.0233 0.0513
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0123 0.0629 0.1709
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0024 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0629 0.302
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.175 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Schistosoma mansoni hypothetical protein 0.0169 0.0893 0.1965
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0058 0.0767
Brugia malayi Thioredoxin reductase 0.0046 0.0183 0.1283
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0017 0.002 0.016
Loa Loa (eye worm) hypothetical protein 0.0021 0.0038 0.0137
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.002 0.0044
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0011 0.0009
Leishmania major UDP-galactopyranose mutase 0.0123 0.0629 1
Plasmodium falciparum glutathione reductase 0.0016 0.0011 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0092 0.0447 0.0983
Echinococcus multilocularis 0.0053 0.0223 0.0491
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.002 0.0048
Loa Loa (eye worm) TK/INSR protein kinase 0.0054 0.0233 0.1087
Schistosoma mansoni tyrosine kinase 0.0091 0.0441 0.0971
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0281 0.0619
Plasmodium vivax glutathione reductase, putative 0.0046 0.0183 0.0477
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0024 0.0099
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.002 0.0163
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0645 0.3634 0.3627
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0482 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0017 0.002 0.0044
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0067 0.089
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0188 0.0414
Plasmodium vivax importin-beta 2, putative 0.0035 0.012 0.0303
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.006 0.2865
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0017 0.002 0.0572
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0058 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0864 0.6328
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.052 0.055
Brugia malayi hypothetical protein 0.0024 0.006 0.0369
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.006 0.0137
Echinococcus multilocularis geminin 0.0169 0.0893 0.1965
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0188 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Echinococcus granulosus GPCR family 2 0.0047 0.0188 0.0414
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.012 0.6355
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.001 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0179 0.0394
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0024 0.0099
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0017 0.002 0.0044
Echinococcus multilocularis GPCR, family 2 0.0047 0.0188 0.0414
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0281 0.0619
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0054 0.0233 0.0513
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.002 0.016
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0188 0.0414
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0179 0.0394
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0011 0.0009
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0183 0.2791
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0011 0.0009
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.052 0.055
Trypanosoma cruzi UDP-galactopyranose mutase 0.0123 0.0629 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0082 0.1161
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0864 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0864 0.6328
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0281 0.2011
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0183 0.0186
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0011 0.0009
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.006 0.08
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Echinococcus granulosus dnaJ subfamily B 0.0803 0.4544 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0011 0.0002
Loa Loa (eye worm) hypothetical protein 0.0047 0.0188 0.0867
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0022
Schistosoma mansoni hypothetical protein 0.0803 0.4544 1
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.05 0.3631
Plasmodium vivax hypothetical protein, conserved 0.0123 0.0629 0.1709
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0082 0.0529
Chlamydia trachomatis protoporphyrinogen oxidase 0.0123 0.0629 0.1707
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0244 0.1141
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0082 0.0529
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0011 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Schistosoma mansoni hypothetical protein 0.004 0.0152 0.0334
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0011 0.0006
Brugia malayi hypothetical protein 0.0123 0.0629 0.4592
Echinococcus granulosus tar DNA binding protein 0.0063 0.0281 0.0619
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0067 0.0157
Schistosoma mansoni hypothetical protein 0.004 0.0152 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Entamoeba histolytica hypothetical protein 0.0024 0.0058 0.0814
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1359 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Loa Loa (eye worm) RNA binding protein 0.0063 0.0281 0.1322
Loa Loa (eye worm) TK/EGFR protein kinase 0.017 0.0901 0.4345
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0017 0.002 0.016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.002 0.0075
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0024 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1359 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0629 0.302
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0588 0.0622
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.049 0.1079
Brugia malayi CHE-14 protein 0.0042 0.0161 0.1118
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.002 0.0572
Echinococcus multilocularis snurportin 1 0.0372 0.206 0.4534
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0161 0.0354
Echinococcus granulosus cpg binding protein 0.006 0.0263 0.0578
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0482 0.106
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.002 0.0572
Loa Loa (eye worm) hypothetical protein 0.0101 0.05 0.2388
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0605 0.2902
Schistosoma mansoni tyrosine kinase 0.0092 0.0447 0.0983
Echinococcus multilocularis protein patched 0.0042 0.0161 0.0354
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0645 0.3634 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0482 0.23
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0183 0.0843
Brugia malayi isocitrate dehydrogenase 0.0016 0.001 0.0001
Brugia malayi Importin beta-1 subunit 0.0035 0.012 0.0816
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.0047 0.0188 0.0414
Brugia malayi Isocitrate dehydrogenase 0.0016 0.001 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.002 0.0044
Loa Loa (eye worm) histone methyltransferase 0.0017 0.002 0.0047
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0183 0.0477
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.004 0.0152 0.0334
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0588 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Schistosoma mansoni importin beta-1 0.0035 0.012 0.0264
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0482 0.3498
Schistosoma mansoni tyrosine kinase 0.0091 0.0441 0.0971
Echinococcus granulosus expressed conserved protein 0.0092 0.0448 0.0985
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0402 0.8269
Plasmodium falciparum thioredoxin reductase 0.0046 0.0183 0.0477
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0024 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1359 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0864 0.6328
Echinococcus granulosus lysine specific histone demethylase 1A 0.0123 0.0629 0.1385
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0011 0.0009
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0645 0.3634 0.3627
Trypanosoma cruzi UDP-galactopyranose mutase 0.0123 0.0629 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0024 0.0053
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0281 0.1322
Mycobacterium ulcerans oxidoreductase 0.0123 0.0629 0.0619
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.0067 0.0918
Echinococcus multilocularis importin subunit beta 1 0.0035 0.012 0.0264
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0645 0.3634 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.002 0.0163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0011 0.0009
Schistosoma mansoni amine oxidase 0.0123 0.0629 0.1385
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.206 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0195 0.0429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0179 0.0394
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0183 0.0402
Echinococcus granulosus lysine specific histone demethylase 1A 0.0123 0.0629 0.1385
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0864 0.6328
Schistosoma mansoni ran 0.0026 0.0067 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0067 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0011 0.0033
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0123 0.0629 0.1709
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0011 0.0023
Toxoplasma gondii thioredoxin reductase 0.0046 0.0183 0.2704
Entamoeba histolytica hypothetical protein 0.0028 0.0082 0.1343
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0188 0.0414
Schistosoma mansoni patched 1 0.0042 0.0161 0.0354
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0123 0.0629 0.302
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1359 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0024 0.0013
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0067 0.0423
Leishmania major importin beta-1 subunit, putative 0.0028 0.0082 0.1161
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0022
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.002 0.0044
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0067 0.0277
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0011 0.0023
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0645 0.3634 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0161 0.1113
Schistosoma mansoni ran 0.0026 0.0067 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0058 0.0348
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0179 0.1255
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0281 0.0619
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0179 0.0394
Echinococcus multilocularis expressed conserved protein 0.0092 0.0448 0.0985
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0127 0.0649 1
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0123 0.0629 0.1709
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0042 0.0161 0.0734
Loa Loa (eye worm) hypothetical protein 0.0147 0.0768 0.3698
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0054 0.0233 0.0513
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0123 0.0629 0.1709
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0058 0.0127
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0024 0.2368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0915 0.6706
Echinococcus multilocularis epidermal growth factor receptor 0.0092 0.0447 0.0983
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Echinococcus granulosus epidermal growth factor receptor 0.017 0.0901 0.1983
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.0768 0.5623
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0024 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0179 0.0394
Onchocerca volvulus 0.0123 0.0629 0.6216
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0011 0.0033
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0024 0.006 0.0241
Brugia malayi Protein kinase domain containing protein 0.0054 0.0233 0.1654
Schistosoma mansoni ap endonuclease 0.0018 0.0024 0.0053
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0082 0.0529
Mycobacterium tuberculosis Conserved hypothetical protein 0.0123 0.0629 0.0667
Trypanosoma brucei trypanothione reductase 0.0046 0.0183 1
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1359 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0588 0.6167
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0024 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Toxoplasma gondii histone lysine-specific demethylase 0.0123 0.0629 0.969
Brugia malayi SWIRM domain containing protein 0.0123 0.0629 0.4592
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0017 0.002 0.0044
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0011 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0011 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.1359 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.052 0.055
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0161 0.0734
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0188 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0067 0.0147
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0645 0.3634 0.3905
Brugia malayi Furin-like cysteine rich region family protein 0.017 0.0901 0.6607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.002 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0864 0.6328
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.002 0.0044
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0017 0.002 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.002 0.016
Entamoeba histolytica Ran family GTPase 0.0026 0.0067 0.1017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.002 0.0075
Schistosoma mansoni hypothetical protein 0.0047 0.0188 0.0414
Loa Loa (eye worm) hypothetical protein 0.0123 0.0629 0.302
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0067 0.0157
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.1359 0.6577
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0123 0.0629 0.0619
Brugia malayi amine oxidase, flavin-containing family protein 0.0123 0.0629 0.4592
Echinococcus multilocularis epidermal growth factor receptor 0.017 0.0901 0.1983
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0645 0.3634 0.3627
Toxoplasma gondii exonuclease III APE 0.0018 0.0024 0.0218
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.001 0.0022
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.012 0.6355
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.006 0.0137
Echinococcus multilocularis dnaJ subfamily B 0.0803 0.4544 1
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0161 0.0354
Brugia malayi CXXC zinc finger family protein 0.0056 0.0244 0.1736
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0017 0.002 0.016
Schistosoma mansoni tyrosine kinase 0.017 0.0901 0.1983
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0011 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0024 0.0053
Brugia malayi RNA, U transporter 1 0.0099 0.049 0.3557
Schistosoma mansoni cpg binding protein 0.0056 0.0244 0.0537
Schistosoma mansoni hypothetical protein 0.0047 0.0188 0.0414
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0024 0.0038
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0011 0.0002
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1627 0.929 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0605 0.2902
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Mycobacterium ulcerans dehydrogenase 0.0123 0.0629 0.0619
Mycobacterium tuberculosis Possible oxidoreductase 0.0123 0.0629 0.0667
Echinococcus multilocularis protoporphyrinogen oxidase 0.0123 0.0629 0.1385
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0058 0.2748
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0645 0.3634 1
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0123 0.0629 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0011 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Brugia malayi TAR-binding protein 0.0063 0.0281 0.2011
Plasmodium falciparum protoporphyrinogen oxidase 0.0123 0.0629 0.1709
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0179 0.0394
Schistosoma mansoni hypothetical protein 0.0372 0.206 0.4534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.002 0.0069
Entamoeba histolytica fatty acid elongase, putative 0.0084 0.0402 0.8269
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0482 0.106
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0188 0.0414
Schistosoma mansoni hypothetical protein 0.0101 0.05 0.11
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0058 0.0127

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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