Detailed information for compound 1436499

Basic information

Technical information
  • TDR Targets ID: 1436499
  • Name: 3-methyl-2-oxo-N-(3,4,5-trimethoxyphenyl)-1,3 -benzoxazole-6-sulfonamide
  • MW: 394.399 | Formula: C17H18N2O7S
  • H donors: 1 H acceptors: 3 LogP: 1.76 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)NS(=O)(=O)c1ccc2c(c1)oc(=O)n2C
  • InChi: 1S/C17H18N2O7S/c1-19-12-6-5-11(9-13(12)26-17(19)20)27(21,22)18-10-7-14(23-2)16(25-4)15(8-10)24-3/h5-9,18H,1-4H3
  • InChiKey: ZMKACOXQJRACQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-keto-3-methyl-N-(3,4,5-trimethoxyphenyl)-1,3-benzoxazole-6-sulfonamide
  • SMR000095231
  • ZINC02323677
  • MLS000118288

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0127 0.0388
Loa Loa (eye worm) glutathione reductase 0.0069 0.0603 0.1727
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0127 0.0388
Loa Loa (eye worm) hypothetical protein 0.0148 0.1414 0.4051
Trypanosoma brucei prolyl endopeptidase 0.013 0.1227 1
Entamoeba histolytica hypothetical protein, conserved 0.0329 0.3284 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2818 1
Brugia malayi hypothetical protein 0.0134 0.127 0.3866
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0014 0.0041
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0058 0.0346
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0398 0.3151
Brugia malayi Thioredoxin reductase 0.0069 0.0603 0.1836
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0058 0.0176
Brugia malayi MH2 domain containing protein 0.0117 0.1091 0.3322
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0365
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0135 0.098
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.2818 1
Mycobacterium ulcerans lipase LipD 0.0075 0.0657 0.4409
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0039
Onchocerca volvulus Peroxidase homolog 0.0255 0.2523 0.7682
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0058 0.0346
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0657 0.1881
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0129 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0127 0.0388
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0127 0.0388
Echinococcus multilocularis transcription factor Dp 1 0.0042 0.0321 0.0321
Schistosoma mansoni apoferritin-2 0.0026 0.0154 0.0469
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0398 0.1362
Echinococcus multilocularis expressed protein 0.0026 0.0154 0.0154
Entamoeba histolytica hypothetical protein, conserved 0.0014 0.0027 0.0034
Schistosoma mansoni hypothetical protein 0.0058 0.0488 0.1486
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0135 0.098
Plasmodium falciparum glutathione reductase 0.0069 0.0603 1
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0657 0.1213
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.042 0.3333
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0127 0.0388
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0014 0.0027 0.0092
Brugia malayi hypothetical protein 0.0043 0.0335 0.102
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0.0027 0.0034
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0014 0.0027 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0657 0.2286
Trypanosoma brucei trypanothione reductase 0.0069 0.0603 0.4845
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0127 0.0365
Brugia malayi glutathione reductase 0.0069 0.0603 0.1836
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0014 0.0027 0.0034
Schistosoma mansoni hypothetical protein 0.0072 0.0633 0.1927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0293 0.0989
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.2818 0.8575
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0014 0.0027 0.0092
Onchocerca volvulus 0.0023 0.0127 0.0388
Toxoplasma gondii thioredoxin reductase 0.0069 0.0603 0.4798
Brugia malayi Animal haem peroxidase family protein 0.0255 0.2523 0.7682
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.042 0.3333
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0083 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0267 0.0894
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0398 0.3151
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0398 0.0398
Plasmodium falciparum thioredoxin reductase 0.0024 0.0135 0.1869
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0293 0.2291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0323 0.1095
Toxoplasma gondii prolyl endopeptidase 0.013 0.1227 1
Toxoplasma gondii NADPH-glutathione reductase 0.0024 0.0135 0.0897
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0657 0.1213
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0293 0.2291
Schistosoma mansoni thyroid hormone receptor 0.0162 0.1558 0.4744
Brugia malayi beta-lactamase 0.0075 0.0657 0.2
Onchocerca volvulus Peroxidasin homolog 0.0255 0.2523 0.7682
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0014 0.0027 0.0092
Echinococcus multilocularis geminin 0.0186 0.1812 0.1812
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0014 0.0027 0.0027
Mycobacterium tuberculosis Probable peptidase 0.0052 0.042 0.0712
Schistosoma mansoni ferritin light chain 0.0026 0.0154 0.0469
Mycobacterium ulcerans hypothetical protein 0.0075 0.0657 0.4409
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0189 0.0617
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0293 0.2291
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.042 0.3333
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0024 0.0135 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0398 0.1362
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0127 0.0365
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0014 0.0027 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0058 0.015
Mycobacterium tuberculosis Conserved protein 0.0075 0.0657 0.1213
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0014 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0014 0.0041
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0039
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0154 0.0149
Loa Loa (eye worm) animal heme peroxidase 0.0255 0.2523 0.7226
Loa Loa (eye worm) hypothetical protein 0.0075 0.0657 0.1881
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0024 0.0135 0.0108
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0232 0.0706
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0058 0.0058
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0232 0.0232
Onchocerca volvulus Peroxidasin homolog 0.0255 0.2523 0.7682
Echinococcus granulosus protein cereblon 0.0329 0.3284 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0024 0.0135 0.0386
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0344 0.1048
Onchocerca volvulus Prolyl endopeptidase homolog 0.013 0.1227 0.3737
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0398 0.3151
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0365
Loa Loa (eye worm) animal heme peroxidase 0.0255 0.2523 0.7226
Brugia malayi ecdysteroid receptor 0.0023 0.0127 0.0388
Brugia malayi hypothetical protein 0.0148 0.1414 0.4307
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0027 0.0082
Schistosoma mansoni survival motor neuron protein 0.0058 0.0488 0.1486
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0127 0.0388
Trypanosoma cruzi oligopeptidase b 0.0052 0.042 0.3333
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0657 0.1213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0127 0.0365
Onchocerca volvulus 0.0075 0.0657 0.2
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0127 0.0388
Brugia malayi Animal haem peroxidase family protein 0.0255 0.2523 0.7682
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0344 0.0985
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0636 0.5123
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0477 0.4808 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0398 0.1139
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0024 0.0135 0.098
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0127 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0293 0.0989
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0657 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0127 0.0388
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0657 0.1213
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0014 0.0027 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0267 0.0894
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0335 0.102
Loa Loa (eye worm) hypothetical protein 0.0106 0.0978 0.2803
Brugia malayi hypothetical protein 0.0012 0.0014 0.0041
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0027 0.0077
Echinococcus multilocularis GPCR, family 2 0.0033 0.0232 0.0232
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2818 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0657 0.1881
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0657 0.2286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0162 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0267 0.0894
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0344 0.1048
Echinococcus multilocularis peroxidasin 0.0255 0.2523 0.2523
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0014 0.0027 0.0082
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0014 0.0027 0.0082
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2836 0.2836
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0083 0.0557
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0024 0.0135 0.1869
Schistosoma mansoni peroxidasin 0.0255 0.2523 0.7682
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0024 0.0135 0.1709
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0083 0.0896
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0657 0.2
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0.0027 0.0034
Brugia malayi prolyl oligopeptidase family protein 0.013 0.1227 0.3737
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0657 0.529
Trypanosoma cruzi prolyl endopeptidase 0.013 0.1227 1
Brugia malayi nuclear receptor RXR 0.0012 0.0014 0.0041
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0657 0.2
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0027 0.0092
Onchocerca volvulus Peroxidase homolog 0.0255 0.2523 0.7682
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0024 0.0135 0.0897
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0127 0.0388
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0058 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0127 0.0388
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0027 0.0082
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0077
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0127 0.0388
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0127 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0398 0.1362
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.013 0.1227 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0127 0.0388
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0127 0.0127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0344 0.0344
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0398 0.1211
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0024 0.0135 0.098
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0129 0.0403
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0344 0.1048
Schistosoma mansoni ferritin 0.0026 0.0154 0.0469
Loa Loa (eye worm) hypothetical protein 0.013 0.1227 0.3515
Echinococcus multilocularis prolyl endopeptidase 0.013 0.1227 0.1227
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0083 0.0083
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0014 0.0039
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0014 0.0027 0.0082
Entamoeba histolytica prolyl oligopeptidase family protein 0.0014 0.0027 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0162 0.0523
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0127 0.0127
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0024 0.0135 0.041
Loa Loa (eye worm) blistered cuticle protein 3 0.0255 0.2523 0.7226
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0398 0.3151
Echinococcus multilocularis protein cereblon 0.0329 0.3284 0.3284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0162 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0189 0.0617
Brugia malayi Animal haem peroxidase family protein 0.0255 0.2523 0.7682
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0127 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0218 0.0722
Onchocerca volvulus 0.0255 0.2523 0.7682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0162 0.0521
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Echinococcus granulosus bloom syndrome protein 0.0023 0.0129 0.0392
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0335 0.102
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0127 0.0388
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0135 0.098
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0058 0.0166
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2818 1
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0027 0.0092
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0024 0.0135 0.0108
Loa Loa (eye worm) hypothetical protein 0.0075 0.0657 0.1881
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.0978 0.2803
Echinococcus granulosus GPCR family 2 0.0033 0.0232 0.0706
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0657 0.2286
Loa Loa (eye worm) beta-lactamase 0.0075 0.0657 0.1881
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2818 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0232 0.0706
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0127 0.0388
Trypanosoma brucei oligopeptidase b 0.0052 0.042 0.3333
Loa Loa (eye worm) animal heme peroxidase 0.0255 0.2523 0.7226
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0027 0.0082
Loa Loa (eye worm) hypothetical protein 0.0072 0.0633 0.1813
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0135 0.098
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0154 0.0163
Brugia malayi Animal haem peroxidase family protein 0.0255 0.2523 0.7682
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0127 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0365
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0657 0.2286
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0657 0.4409
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0083 0.0557
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.0978 0.298
Schistosoma mansoni thyroid hormone receptor 0.0162 0.1558 0.4744
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0014 0.0027 0.0027
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0398 0.1168
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0083 0.0557
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0052 0.042 0.2407
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0365
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Loa Loa (eye worm) hypothetical protein 0.0349 0.3491 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0232 0.0706
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0154 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0039
Schistosoma mansoni hypothetical protein 0.0186 0.1812 0.5517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0162 0.0521
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0099 0.1257
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0154 0.0149
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0069 0.0603 0.1099
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0154 0.0163
Echinococcus multilocularis thioredoxin glutathione reductase 0.0069 0.0603 0.0603
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0127 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0344 0.1048
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.2818 1
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.0977
Brugia malayi hypothetical protein 0.0329 0.3284 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0127 0.0365
Mycobacterium tuberculosis Probable oxidoreductase 0.0024 0.0135 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0127 0.0388
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.0977
Echinococcus granulosus prolyl endopeptidase 0.013 0.1227 0.3737
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0127 0.0388
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0014 0.0027 0.0092
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0083 0.047
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0058 0.0346
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0127 0.0365
Onchocerca volvulus 0.0075 0.0657 0.2
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0232 0.0664
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0127 0.0388
Brugia malayi Peroxidasin 0.0255 0.2523 0.7682
Onchocerca volvulus 0.0255 0.2523 0.7682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0058 0.015
Schistosoma mansoni hypothetical protein 0.0033 0.0232 0.0706
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0135 0.098
Brugia malayi beta-lactamase family protein 0.0075 0.0657 0.2
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0398 0.1211
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0636 0.5123
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0127 0.0388
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0018 0.0069 0.0209
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0657 1
Brugia malayi prolyl oligopeptidase family protein 0.0014 0.0027 0.0082
Brugia malayi nuclear receptor NHR-88 0.0023 0.0127 0.0388
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.013 0.1227 0.3737
Schistosoma mansoni hypothetical protein 0.0033 0.0232 0.0706
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0657 0.2286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0344 0.0344
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0398 0.3151
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.042 0.3333
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0014 0.0027 0.0082
Schistosoma mansoni hypothetical protein 0.0186 0.1812 0.5517
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0024 0.0135 0.0135
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0127 0.0127
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0232 0.0706
Echinococcus granulosus Dipeptidyl peptidase 9 0.0014 0.0027 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2818 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0073 0.0636 0.1938
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0014 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0014 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0267 0.0894
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0398 0.3151
Onchocerca volvulus Huntingtin homolog 0.0148 0.1414 0.4307
Leishmania major hypothetical protein, conserved 0.0075 0.0657 0.529
Loa Loa (eye worm) hypothetical protein 0.0075 0.0657 0.1881
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0058 0.015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0127 0.0388
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0058 0.015
Onchocerca volvulus 0.0255 0.2523 0.7682
Onchocerca volvulus Dual oxidase homolog 0.0255 0.2523 0.7682
Schistosoma mansoni apoferritin-2 0.0026 0.0154 0.0469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0162 0.0521
Echinococcus granulosus geminin 0.0186 0.1812 0.5517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0293 0.0989
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0192 0.0628
Brugia malayi hypothetical protein 0.0255 0.2523 0.7682
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.005 0.037
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0398 0.1168
Trypanosoma cruzi trypanothione reductase, putative 0.0069 0.0603 0.4845
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0657 0.2
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2818 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0058 0.0346
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Loa Loa (eye worm) hypothetical protein 0.0075 0.0657 0.1881
Mycobacterium tuberculosis Conserved protein 0.0075 0.0657 0.1213
Trichomonas vaginalis ferritin, putative 0.0026 0.0154 0.0492
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2818 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0398 0.1211
Schistosoma mansoni ferritin 0.0026 0.0154 0.0469
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.2818 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1091 0.3125
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0127 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0267 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0024 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0127 0.0365
Brugia malayi follicle stimulating hormone receptor 0.0255 0.2518 0.7668
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0024 0.0135 0.1869
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0365
Onchocerca volvulus Chorion peroxidase homolog 0.0255 0.2523 0.7682
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0083 0.0239
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0024 0.0135 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0127 0.0365
Trichomonas vaginalis mercuric reductase, putative 0.0024 0.0135 0.0424
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0127 0.0388
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0073 0.0636 0.1823
Plasmodium falciparum thioredoxin reductase 0.0069 0.0603 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0232 0.0232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0127 0.0127
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0127 0.0388
Schistosoma mansoni hypothetical protein 0.0329 0.3284 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0344 0.1048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0039
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0058 0.0346
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0083 0.047
Echinococcus multilocularis acylamino acid releasing enzyme 0.0014 0.0027 0.0027
Echinococcus granulosus ferritin 0.0026 0.0154 0.0469
Onchocerca volvulus Protein cereblon homolog 0.0329 0.3284 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0127 0.0388
Brugia malayi steroid hormone receptor 0.0023 0.0127 0.0388
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0344 0.1048
Loa Loa (eye worm) hypothetical protein 0.0019 0.008 0.0228
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0657 0.529
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2836 0.8635
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0024 0.0135 0.041
Trichomonas vaginalis esterase, putative 0.0075 0.0657 0.2286
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0127 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0162 0.0523
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0657 0.1213
Brugia malayi isocitrate dehydrogenase 0.0019 0.0083 0.0254
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0058 0.0176
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0657 0.1213
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0024 0.0135 0.1709
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0129 0.0129
Brugia malayi nuclear hormone receptor 0.0023 0.0127 0.0388
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0083 0.0557
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0014 0.0027 0.0082
Brugia malayi Blistered cuticle protein 3 0.0255 0.2523 0.7682
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1091 0.3125
Loa Loa (eye worm) hypothetical protein 0.0075 0.0657 0.1881
Brugia malayi Animal haem peroxidase family protein 0.0255 0.2523 0.7682
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0083 0.0083
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0127 0.0388
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0127 0.0388
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0024 0.0135 0.098
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0127 0.0127
Schistosoma mansoni coup transcription factor 0.0023 0.0127 0.0388
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0058 0.0346
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0633 0.1927
Loa Loa (eye worm) RecQ helicase 0.0023 0.0129 0.0369
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0365
Loa Loa (eye worm) animal heme peroxidase 0.0255 0.2523 0.7226
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0073 0.0636 0.1938
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0018 0.0069 0.0209
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0127 0.0388
Schistosoma mansoni ferritin light chain 0.0026 0.0154 0.0469
Plasmodium vivax glutathione reductase, putative 0.0069 0.0603 0.9144
Plasmodium vivax thioredoxin reductase, putative 0.0069 0.0603 0.9144
Brugia malayi beta-lactamase family protein 0.0075 0.0657 0.2
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0127 0.0388
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0024 0.0135 0.098
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0073 0.0636 0.5123
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0083 0.0083
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0024 0.0135 0.098
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.042 0.3333
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.013 0.1227 0.3737
Plasmodium falciparum glutathione reductase 0.0024 0.0135 0.1869
Schistosoma mansoni hypothetical protein 0.0139 0.1317 0.401
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0329 0.3284 0.9406
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0129 0.0403
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0657 0.2
Loa Loa (eye worm) hypothetical protein 0.0033 0.0232 0.0664
Schistosoma mansoni hypothetical protein 0.0033 0.0232 0.0706
Leishmania major trypanothione reductase 0.0069 0.0603 0.4845
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0024 0.0135 0.041
Trypanosoma cruzi oligopeptidase b 0.0052 0.042 0.3333
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0014 0.0027 0.0092
Loa Loa (eye worm) hypothetical protein 0.0014 0.0027 0.0077
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.0977
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0127 0.0388
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0073 0.0636 0.0636
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0073 0.0636 0.1938
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0127 0.0388
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0083 0.0254
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0083 0.098
Brugia malayi hypothetical protein 0.0012 0.0014 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0657 0.529
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0135 0.098
Loa Loa (eye worm) hypothetical protein 0.0286 0.2836 0.8122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0293 0.0989
Trichomonas vaginalis glutathione reductase, putative 0.0024 0.0135 0.0424
Giardia lamblia GTOR 0.0049 0.0398 0.1328
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0078 0.0237
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0154 0.0072
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0127 0.0388
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0335 0.0335
Schistosoma mansoni hypothetical protein 0.0043 0.0335 0.102
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0014 0.0014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0488 0.1486
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0073 0.0636 0.1899
Schistosoma mansoni ferritin 0.0026 0.0154 0.0469
Onchocerca volvulus 0.0058 0.0488 0.1486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0058 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0267 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0127 0.0365
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0139 0.1317 0.1317
Echinococcus granulosus thioredoxin glutathione reductase 0.0069 0.0603 0.1836
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0083 0.0083
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0127 0.0388
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0014 0.0027 0.004
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.0978 0.298
Schistosoma mansoni hypothetical protein 0.0033 0.0232 0.0706
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0073 0.0636 0.5123
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.042 0.2407
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0135 0.098
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0083 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0293 0.0989
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.042 0.0712
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0048 0.0178
Toxoplasma gondii ABC1 family protein 0.0075 0.0657 0.5247
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0024 0.0135 0.098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0229 0.0761
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0657 0.4409
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0135 0.098
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0021 0.0099 0.0684
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.1558 0.1558
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0116 0.1087 0.2123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0135 0.098
Entamoeba histolytica hypothetical protein 0.0043 0.0335 0.0977
Mycobacterium leprae Probable lipase LipE 0.0075 0.0657 0.4409
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1319 1
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0657 0.4409
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.2818 0.8575
Loa Loa (eye worm) prolyl oligopeptidase 0.0014 0.0027 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0192 0.0628
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0127 0.0388
Echinococcus granulosus peroxidasin 0.0255 0.2523 0.7682
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0255 0.2518 0.7213
Brugia malayi hypothetical protein 0.0286 0.2836 0.8635
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0127 0.0388
Mycobacterium ulcerans beta-lactamase 0.0075 0.0657 0.4409
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0192 0.0628
Loa Loa (eye worm) hypothetical protein 0.0023 0.0127 0.0365
Loa Loa (eye worm) hypothetical protein 0.0148 0.1414 0.4051
Onchocerca volvulus Huntingtin homolog 0.0148 0.1414 0.4307
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0657 0.1213
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0014 0.0027 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0267 0.0894
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0024 0.0135 0.098
Schistosoma mansoni ferritin 0.0026 0.0154 0.0469
Schistosoma mansoni peroxidasin 0.0255 0.2523 0.7682
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0267 0.1996
Onchocerca volvulus 0.0075 0.0657 0.2
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1319 0.2615
Loa Loa (eye worm) thioredoxin reductase 0.0069 0.0603 0.1727
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0083 0.0557
Echinococcus granulosus acylamino acid releasing enzyme 0.0014 0.0027 0.0082
Echinococcus granulosus expressed protein 0.0026 0.0154 0.0469
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1319 1
Loa Loa (eye worm) hypothetical protein 0.0255 0.2523 0.7226
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0139 0.1317 0.401
Echinococcus granulosus transcription factor Dp 1 0.0042 0.0321 0.0976
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0154 0.0163
Echinococcus multilocularis ferritin 0.0026 0.0154 0.0154
Mycobacterium tuberculosis Conserved protein 0.0075 0.0657 0.1213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0127 0.0127
Leishmania major oligopeptidase b 0.0052 0.042 0.3333
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0024 0.0135 0.098
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0128 0.0926
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0127 0.0388

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 11.5821 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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