Detailed information for compound 1442701

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 343.74 | Formula: C17H11ClFN3O2
  • H donors: 2 H acceptors: 3 LogP: 3.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1nc2ccccc2c(c1)C(=O)NNC(=O)c1ccccc1F
  • InChi: 1S/C17H11ClFN3O2/c18-15-9-12(10-5-2-4-8-14(10)20-15)17(24)22-21-16(23)11-6-1-3-7-13(11)19/h1-9H,(H,21,23)(H,22,24)
  • InChiKey: WIOGTFBUACOWSE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tubulin alpha 0.0047 0.0093 0.0101
Loa Loa (eye worm) tubulin alpha chain 0.0087 0.0245 0.1788
Echinococcus multilocularis multidrug resistance protein 1 0.0032 0.0036 0.0039
Trypanosoma brucei beta tubulin 0.0047 0.0093 0.0312
Brugia malayi ABC transporter family protein 0.0025 0.0011 0.0003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0042 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0448 0.3326
Echinococcus multilocularis geminin 0.0338 0.1193 0.1294
Plasmodium vivax tubulin gamma chain, putative 0.0047 0.0093 0.0312
Echinococcus multilocularis Tubulin alpha 1 chain 0.0087 0.0245 0.0266
Loa Loa (eye worm) hypothetical protein 0.0071 0.0186 0.1341
Entamoeba histolytica P-glycoprotein-2 0.0032 0.0036 0.0462
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0036 0.1453
Echinococcus granulosus Tubulin alpha 1 chain 0.0087 0.0245 0.2052
Toxoplasma gondii kinesin motor domain-containing protein 0.0026 0.0015 0.0015
Echinococcus multilocularis Niemann Pick C1 protein 0.0287 0.1 0.1085
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0036 0.1453
Schistosoma mansoni amine oxidase 0.0188 0.0627 0.4679
Echinococcus multilocularis multidrug resistance protein 1 0.0032 0.0036 0.0039
Toxoplasma gondii histone lysine-specific demethylase 0.0188 0.0627 0.2348
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Echinococcus multilocularis tubulin beta 1 chain 0.0047 0.0093 0.0101
Plasmodium falciparum alpha tubulin 2 0.0087 0.0245 0.0891
Loa Loa (eye worm) hypothetical protein 0.0188 0.0627 0.4678
Echinococcus multilocularis Tubulin beta 2C chain 0.0047 0.0093 0.0101
Trypanosoma brucei alpha tubulin 0.0087 0.0245 0.0891
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0448 0.3325
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0186 0.0202
Trichomonas vaginalis tubulin alpha chain, putative 0.0026 0.0016 0.0672
Echinococcus granulosus beta tubulin 0.0047 0.0093 0.0781
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0186 0.0191
Echinococcus granulosus tubulin alpha chain 0.0087 0.0245 0.2052
Loa Loa (eye worm) tyrosinase 1 0.0374 0.1329 1
Schistosoma mansoni hypothetical protein 0.0033 0.0042 0.0252
Echinococcus granulosus Protein patched homolog 1 0.0086 0.0242 0.2027
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0036 0.1453
Echinococcus granulosus Niemann Pick C1 protein 0.0287 0.1 0.8383
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0009 0.0061
Plasmodium falciparum importin beta, putative 0.0029 0.0025 0.0052
Echinococcus granulosus geminin 0.0338 0.1193 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0188 0.0627 0.0666
Echinococcus granulosus Tubulin alpha 1 chain 0.0087 0.0245 0.2052
Echinococcus granulosus lysine specific histone demethylase 1A 0.0188 0.0627 0.5251
Brugia malayi beta-lactamase family protein 0.0071 0.0186 0.0248
Echinococcus multilocularis Tubulin alpha 1 chain 0.0087 0.0245 0.0266
Echinococcus multilocularis tubulin alpha chain 0.0087 0.0245 0.0266
Schistosoma mansoni tyrosine kinase 0.0095 0.0273 0.2006
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0036 0.0039
Giardia lamblia Beta tubulin 0.0047 0.0093 0.0298
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0186 0.0191
Echinococcus granulosus tubulin alpha 3 chain 0.0087 0.0245 0.2052
Brugia malayi Importin beta-1 subunit 0.0029 0.0025 0.0023
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0036 0.1453
Echinococcus granulosus kinesin family 1 0.0202 0.0678 0.5678
Trichomonas vaginalis tubulin epsilon chain, putative 0.0047 0.0093 0.3806
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0188 0.0627 0.4679
Trichomonas vaginalis tubulin beta chain, putative 0.0047 0.0093 0.3806
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0011 0.0026
Plasmodium vivax hypothetical protein, conserved 0.0188 0.0627 0.2348
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0188 0.0627 0.2348
Brugia malayi hypothetical protein 0.0025 0.0011 0.0004
Toxoplasma gondii beta tubulin 0.0047 0.0093 0.0312
Echinococcus multilocularis tubulin alpha chain 0.0087 0.0245 0.0266
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0036 0.0298
Toxoplasma gondii beta-1 tubulin, putative 0.0047 0.0093 0.0312
Onchocerca volvulus 0.0026 0.0016 0.0008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0186 0.0177
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0282 0.2367
Loa Loa (eye worm) TAR-binding protein 0.013 0.0406 0.3009
Echinococcus multilocularis hypothetical protein 0.0087 0.0245 0.0266
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0036 0.0039
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0186 0.0177
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0036 0.1453
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0042 0.025
Schistosoma mansoni tar DNA-binding protein 0.013 0.0406 0.301
Echinococcus granulosus Niemann Pick C1 protein 0.0201 0.0675 0.5655
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0641 0.2336 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0036 0.1453
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Echinococcus multilocularis 0.0092 0.0262 0.0284
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0036 0.1453
Schistosoma mansoni tubulin subunit beta 0.0047 0.0093 0.0642
Echinococcus granulosus epidermal growth factor receptor 0.0296 0.1034 0.8662
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0187 0.025
Mycobacterium ulcerans dehydrogenase 0.0188 0.0627 0.0618
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0201 0.0675 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0087 0.0245 0.0266
Echinococcus granulosus lysine specific histone demethylase 1A 0.0188 0.0627 0.5251
Trypanosoma cruzi UDP-galactopyranose mutase 0.0188 0.0627 0.2368
Echinococcus multilocularis peroxisome assembly protein 26 0.0087 0.0245 0.0266
Trichomonas vaginalis abcb9, putative 0.0032 0.0036 0.1453
Mycobacterium ulcerans beta-lactamase 0.0071 0.0186 0.0177
Loa Loa (eye worm) hypothetical protein 0.0374 0.1329 1
Echinococcus granulosus tubulin gamma 1 chain 0.0047 0.0093 0.0781
Loa Loa (eye worm) hypothetical protein 0.0032 0.0036 0.0204
Loa Loa (eye worm) tubulin alpha 2 0.004 0.0068 0.045
Giardia lamblia Telomerase catalytic subunit 0.0719 0.2631 1
Leishmania major telomerase reverse transcriptase, putative 0.0719 0.2631 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.0627 0.4678
Chlamydia trachomatis protoporphyrinogen oxidase 0.0188 0.0627 0.2569
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Brugia malayi Furin-like cysteine rich region family protein 0.0296 0.1034 0.1437
Trichomonas vaginalis abcb9, putative 0.0032 0.0036 0.1453
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0036 0.1453
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0406 0.3009
Giardia lamblia Beta tubulin 0.0047 0.0093 0.0298
Loa Loa (eye worm) hypothetical protein 0.0033 0.0042 0.025
Brugia malayi SWIRM domain containing protein 0.0188 0.0627 0.0866
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0159 0.1329
Brugia malayi tubulin alpha chain - mouse 0.0087 0.0245 0.0331
Loa Loa (eye worm) hypothetical protein 0.0188 0.0627 0.4678
Brugia malayi tubulin alpha-2 chain 0.0087 0.0245 0.0331
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0186 0.1558
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0188 0.0627 0.4679
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0188 0.0627 0.2348
Trypanosoma brucei ABC transporter, putative 0.0029 0.0028 0.0062
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0029 0.0028 0.0088
Schistosoma mansoni alpha tubulin 0.0087 0.0245 0.179
Mycobacterium tuberculosis Conserved protein 0.0071 0.0186 0.0191
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0282 0.2074
Schistosoma mansoni tubulin subunit beta 0.0047 0.0093 0.0642
Echinococcus multilocularis tubulin alpha 1C chain 0.0087 0.0245 0.0266
Brugia malayi alpha-tubulin 0.0087 0.0245 0.0331
Echinococcus granulosus tubulin alpha 1C chain 0.0087 0.0245 0.2052
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0641 0.2336 0.2508
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0204 0.0687 0.5133
Loa Loa (eye worm) tubulin alpha-3 chain 0.006 0.0145 0.1031
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0026 0.0016 0.0672
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0053 0.0441
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0053 0.0057
Schistosoma mansoni hypothetical protein 0.0175 0.0579 0.4317
Entamoeba histolytica P-glycoprotein-2 0.0032 0.0036 0.0462
Plasmodium falciparum tubulin gamma chain 0.0047 0.0093 0.0312
Mycobacterium tuberculosis Conserved hypothetical protein 0.0188 0.0627 0.0666
Toxoplasma gondii alpha tubulin TUBA1 0.0087 0.0245 0.0891
Trichomonas vaginalis tubulin alpha chain, putative 0.0026 0.0016 0.0672
Trypanosoma brucei ATP-binding cassette protein, putative 0.0029 0.0028 0.0062
Echinococcus multilocularis insulin receptor 0.0095 0.0273 0.0297
Loa Loa (eye worm) hypothetical protein 0.0201 0.0675 0.5044
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0036 0.1453
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0005 0.0188
Trichomonas vaginalis tubulin epsilon chain, putative 0.0087 0.0245 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0032 0.0036 0.1453
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Entamoeba histolytica P-glycoprotein-2, putative 0.0032 0.0036 0.0462
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.1638 0.1755
Echinococcus granulosus sterol regulatory element binding protein 0.0086 0.0242 0.2027
Echinococcus multilocularis Niemann Pick C1 protein 0.0201 0.0675 0.0732
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0029 0.0028 0.0088
Brugia malayi CHE-14 protein 0.0086 0.0242 0.0327
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0036 0.1453
Trichomonas vaginalis taga, putative 0.0032 0.0036 0.1453
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0025 0.0052
Trypanosoma brucei telomerase reverse transcriptase 0.0719 0.2631 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.0627 0.4678
Loa Loa (eye worm) hypothetical protein 0.0106 0.0315 0.232
Toxoplasma gondii ABC1 family protein 0.0071 0.0186 0.0666
Mycobacterium ulcerans lipase LipD 0.0071 0.0186 0.0177
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0036 0.1453
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Trypanosoma brucei tubulin gamma chain 0.0047 0.0093 0.0312
Echinococcus multilocularis sterol regulatory element binding protein 0.0086 0.0242 0.0262
Echinococcus multilocularis GPCR, family 2 0.0033 0.0042 0.0045
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0032 0.0036 0.0118
Loa Loa (eye worm) BEN-1 protein 0.0047 0.0093 0.064
Schistosoma mansoni tyrosine kinase 0.0296 0.1034 0.776
Echinococcus multilocularis tubulin alpha 3 chain 0.0087 0.0245 0.0266
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0448 0.0486
Trypanosoma brucei alpha tubulin 0.0087 0.0245 0.0891
Echinococcus multilocularis kinesin family 1 0.0202 0.0678 0.0735
Mycobacterium tuberculosis Conserved protein 0.0071 0.0186 0.0191
Giardia lamblia Gamma tubulin 0.0047 0.0093 0.0298
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0042 0.0045
Plasmodium vivax tubulin epsilon chain, putative 0.0047 0.0093 0.0312
Echinococcus multilocularis 0.0188 0.0627 0.0679
Brugia malayi hypothetical protein 0.0188 0.0627 0.0866
Schistosoma mansoni tyrosinase precursor 0.0374 0.1329 1
Entamoeba histolytica tubulin family protein 0.0047 0.0093 0.1322
Onchocerca volvulus 0.0374 0.1329 0.1342
Plasmodium falciparum alpha tubulin 1 0.0087 0.0245 0.0891
Echinococcus granulosus Tubulin beta 2C chain 0.0047 0.0093 0.0781
Trichomonas vaginalis tubulin beta chain, putative 0.0087 0.0245 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0036 0.0039
Schistosoma mansoni tar DNA-binding protein 0.013 0.0406 0.301
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0374 0.1329 0.1852
Toxoplasma gondii beta-tubulin, putative 0.0047 0.0093 0.0312
Schistosoma mansoni tar DNA-binding protein 0.013 0.0406 0.301
Echinococcus granulosus tubulin alpha 3 chain 0.0087 0.0245 0.2052
Loa Loa (eye worm) alpha-tubulin 0.0087 0.0245 0.1788
Loa Loa (eye worm) hypothetical protein 0.0188 0.0627 0.4678
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0067 0.0168 0.1207
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0036 0.1453
Schistosoma mansoni transient receptor potential channel 0.0064 0.0159 0.1136
Brugia malayi Niemann-Pick C1 protein precursor 0.0201 0.0675 0.0934
Schistosoma mansoni hypothetical protein 0.0033 0.0042 0.0252
Entamoeba histolytica tubulin alpha-1 chain 0.0087 0.0245 0.3585
Schistosoma mansoni tubulin subunit alpha 0.0087 0.0245 0.179
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0032 0.0036 0.0204
Trichomonas vaginalis tubulin gamma chain, putative 0.0047 0.0093 0.3806
Echinococcus granulosus tubulin alpha chain 0.0087 0.0245 0.2052
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0032 0.0036 0.0029
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0186 0.0191
Giardia lamblia ABC transporter 0.0029 0.0025 0.0038
Loa Loa (eye worm) ShTK domain-containing protein 0.0374 0.1329 1
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0186 0.0191
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0231 0.3374
Mycobacterium ulcerans oxidoreductase 0.0188 0.0627 0.0618
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0056 0.0473
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0332
Giardia lamblia Alpha-tubulin 0.0087 0.0245 0.0878
Brugia malayi Common central domain of tyrosinase family protein 0.0374 0.1329 0.1852
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0641 0.2336 0.5
Trypanosoma cruzi alpha tubulin, putative 0.0087 0.0245 0.0915
Brugia malayi TAR-binding protein 0.013 0.0406 0.0557
Toxoplasma gondii alpha-tubulin I, putative 0.0087 0.0245 0.0891
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0448 0.3326
Mycobacterium leprae Probable lipase LipE 0.0071 0.0186 0.2867
Brugia malayi ShTK domain containing protein 0.0374 0.1329 0.1852
Echinococcus granulosus GPCR family 2 0.0033 0.0042 0.035
Loa Loa (eye worm) tubulin alpha 2 0.0067 0.0168 0.1207
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0641 0.2336 0.8876
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.0312 0.2299
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0231 0.3374
Echinococcus granulosus tubulin subunit beta 0.0047 0.0093 0.0781
Brugia malayi Telomerase reverse transcriptase 0.1913 0.7139 1
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0028 0.0019
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0025 0.0052
Loa Loa (eye worm) tubulin alpha 2 0.0067 0.0168 0.1207
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0186 0.0666
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0047 0.0093 0.0312
Plasmodium vivax tubulin beta chain, putative 0.0047 0.0093 0.0312
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Entamoeba histolytica hypothetical protein 0.0037 0.0056 0.0773
Brugia malayi RNA, U transporter 1 0.0082 0.0226 0.0304
Plasmodium falciparum tubulin epsilon chain, putative 0.0047 0.0093 0.0312
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0095 0.0273 0.2291
Schistosoma mansoni tyrosinase precursor 0.0374 0.1329 1
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Echinococcus granulosus beta tubulin 0.0047 0.0093 0.0781
Loa Loa (eye worm) TK/EGFR protein kinase 0.0296 0.1034 0.776
Loa Loa (eye worm) kinesin-like protein KLP2 0.0026 0.0015 0.005
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0188 0.0627 0.0679
Echinococcus multilocularis tubulin alpha chain 0.0087 0.0245 0.0266
Brugia malayi Tubulin gamma chain 0.0047 0.0093 0.0119
Plasmodium falciparum ABC transporter G family member 2 0.0029 0.0028 0.0062
Brugia malayi Protein kinase domain containing protein 0.0095 0.0273 0.0371
Echinococcus multilocularis tubulin subunit beta 0.0047 0.0093 0.0101
Schistosoma mansoni ABC transporter 0.0025 0.0011 0.0019
Echinococcus granulosus peroxisome assembly protein 26 0.0087 0.0245 0.2052
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0036 0.0298
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0186 0.7589
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0448 0.0616
Toxoplasma gondii RNA-directed DNA polymerase 0.0719 0.2631 1
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0448 0.3326
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0188 0.0627 0.2348
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Loa Loa (eye worm) hypothetical protein 0.0029 0.0025 0.0125
Trypanosoma brucei epsilon tubulin 0.0047 0.0093 0.0312
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0036 0.0298
Schistosoma mansoni tubulin subunit beta 0.0047 0.0093 0.0642
Echinococcus granulosus tubulin alpha 1C chain 0.0087 0.0245 0.2052
Plasmodium vivax ABC transporter G family member 2, putative 0.0029 0.0028 0.0062
Brugia malayi beta-lactamase family protein 0.0071 0.0186 0.0248
Loa Loa (eye worm) alpha-tubulin 0.0087 0.0245 0.1788
Schistosoma mansoni multidrug resistance protein 0.0032 0.0036 0.0205
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0186 0.1343
Echinococcus granulosus epidermal growth factor receptor 0.0159 0.0517 0.433
Echinococcus multilocularis tubulin epsilon chain 0.0047 0.0093 0.0101
Brugia malayi beta-lactamase 0.0071 0.0186 0.0248
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0087 0.0245 1
Echinococcus granulosus tubulin alpha 0.0047 0.0093 0.0781
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0188 0.0627 1
Giardia lamblia Beta tubulin 0.0047 0.0093 0.0298
Loa Loa (eye worm) hypothetical protein 0.0105 0.0312 0.2299
Schistosoma mansoni hypothetical protein 0.0338 0.1193 0.8969
Loa Loa (eye worm) hypothetical protein 0.0061 0.0146 0.1042
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0036 0.1453
Trichomonas vaginalis tubulin epsilon chain, putative 0.0087 0.0245 1
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0036 0.1453
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Schistosoma mansoni transient receptor potential channel 0.0064 0.0159 0.1136
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0036 0.1453
Loa Loa (eye worm) hypothetical protein 0.0032 0.0036 0.0204
Schistosoma mansoni hypothetical protein 0.0083 0.023 0.1678
Trypanosoma brucei beta tubulin 0.0047 0.0093 0.0312
Loa Loa (eye worm) hypothetical protein 0.0188 0.0627 0.4678
Echinococcus multilocularis Tubulin beta 2C chain 0.0047 0.0093 0.0101
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2464 0.9221 1
Trypanosoma cruzi epsilon tubulin, putative 0.0047 0.0093 0.0337
Entamoeba histolytica P-glycoprotein-5 0.0032 0.0036 0.0462
Loa Loa (eye worm) tubulin alpha chain 0.0087 0.0245 0.1788
Echinococcus multilocularis protoporphyrinogen oxidase 0.0188 0.0627 0.0679
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Schistosoma mansoni tubulin subunit alpha 0.0087 0.0245 0.179
Trichomonas vaginalis tubulin alpha chain, putative 0.0026 0.0016 0.0672
Loa Loa (eye worm) hypothetical protein 0.0071 0.0186 0.1341
Loa Loa (eye worm) beta-tubulin 0.0047 0.0093 0.064
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0186 0.7589
Schistosoma mansoni tar DNA-binding protein 0.013 0.0406 0.301
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0406 0.0557
Brugia malayi Tubulin beta-1 chain 0.0047 0.0093 0.0119
Trypanosoma brucei alpha tubulin 0.0087 0.0245 0.0891
Onchocerca volvulus 0.0374 0.1329 0.1342
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0641 0.2336 0.233
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0036 0.0298
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0005 0.0188
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0032 0.0036 0.1453
Echinococcus multilocularis epidermal growth factor receptor 0.0159 0.0517 0.056
Entamoeba histolytica hypothetical protein 0.0037 0.0056 0.0773
Plasmodium vivax multidrug resistance protein 1, putative 0.0032 0.0036 0.0092
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0025 0.0052
Echinococcus multilocularis tar DNA binding protein 0.013 0.0406 0.044
Echinococcus granulosus Tubulin beta 2C chain 0.0047 0.0093 0.0781
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0186 0.1341
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0029 0.0028 0.0146
Mycobacterium ulcerans hypothetical protein 0.0071 0.0186 0.0177
Plasmodium falciparum tubulin beta chain 0.0047 0.0093 0.0312
Plasmodium vivax tubulin alpha chain, putative 0.0087 0.0245 0.0891
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0028 0.0019
Loa Loa (eye worm) multidrug resistance protein 3 0.0032 0.0036 0.0204
Trypanosoma cruzi UDP-galactopyranose mutase 0.0188 0.0627 0.2368
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0186 0.7589
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Schistosoma mansoni hypothetical protein 0.0072 0.0187 0.1352
Echinococcus granulosus tubulin alpha chain 0.0087 0.0245 0.2052
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0374 0.1329 0.1852
Leishmania major UDP-galactopyranose mutase 0.0188 0.0627 0.2368
Echinococcus multilocularis expressed conserved protein 0.0189 0.0629 0.0682
Echinococcus multilocularis snurportin 1 0.0307 0.1077 0.1168
Brugia malayi amine oxidase, flavin-containing family protein 0.0188 0.0627 0.0866
Onchocerca volvulus 0.0188 0.0627 0.0628
Brugia malayi Tubulin beta chain 0.0026 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0097 0.0282 0.2073
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0641 0.2336 0.233
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0009 0.0061
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0036 0.1453
Echinococcus granulosus tar DNA binding protein 0.013 0.0406 0.3403
Onchocerca volvulus 0.0374 0.1329 0.1342
Trichomonas vaginalis tubulin epsilon chain, putative 0.0047 0.0093 0.3806
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0032 0.0036 0.0092
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.267 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0005 0.0188
Trypanosoma brucei alpha tubulin 0.0087 0.0245 0.0891
Loa Loa (eye worm) ABC transporter 0.0025 0.0011 0.0018
Trichomonas vaginalis esterase, putative 0.0071 0.0186 0.7589
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.2631 0.9853 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0047 0.0093 0.064
Trichomonas vaginalis abcb9, putative 0.0032 0.0036 0.1453
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0028 0.0233
Schistosoma mansoni tubulin subunit alpha 0.0087 0.0245 0.179
Trichomonas vaginalis tubulin, putative 0.0047 0.0093 0.3806
Schistosoma mansoni alpha tubulin 0.0087 0.0245 0.179
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0036 0.0039
Echinococcus granulosus Tubulin beta 2C chain 0.0047 0.0093 0.0781
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0095 0.0273 0.0297
Loa Loa (eye worm) hypothetical protein 0.0086 0.0242 0.1766
Trichomonas vaginalis tubulin alpha chain, putative 0.0047 0.0093 0.3806
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0231 0.3374
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.0312 0.0426
Schistosoma mansoni tyrosine kinase 0.0095 0.0273 0.2006
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0028 0.003
Schistosoma mansoni multidrug resistance protein 0.0032 0.0036 0.0205
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0448 0.0486
Schistosoma mansoni multidrug resistance protein 0.0032 0.0036 0.0205
Schistosoma mansoni hypothetical protein 0.0083 0.023 0.1678
Loa Loa (eye worm) hypothetical protein 0.0071 0.0186 0.1341
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0028 0.0019
Trypanosoma brucei beta tubulin 0.0047 0.0093 0.0312
Brugia malayi Tubulin alpha chain 0.0087 0.0245 0.0331
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0032 0.0036 0.0039
Loa Loa (eye worm) ShTK domain-containing protein 0.0374 0.1329 1
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0186 0.2867
Entamoeba histolytica P-glycoprotein 5, putative 0.0032 0.0036 0.0462
Loa Loa (eye worm) tubulin alpha-2 chain 0.0087 0.0245 0.1788
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0186 0.0248
Schistosoma mansoni hypothetical protein 0.0033 0.0042 0.0252
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0028 0.003
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0641 0.2336 0.8876
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0231 0.3374
Echinococcus granulosus Tubulin alpha 1 chain 0.0087 0.0245 0.2052
Onchocerca volvulus 0.0071 0.0186 0.018
Schistosoma mansoni tyrosine kinase 0.0159 0.0517 0.3847
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0186 0.0191
Entamoeba histolytica P-glyco protein 6, putative 0.0032 0.0036 0.0462
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0056 0.0363
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Loa Loa (eye worm) tubulin beta-4 chain 0.0047 0.0093 0.064
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Schistosoma mansoni tyrosine kinase 0.0159 0.0517 0.3847
Echinococcus granulosus tubulin alpha chain 0.0087 0.0245 0.2052
Brugia malayi Tubulin alpha-2 chain 0.0087 0.0245 0.0331
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0086 0.0242 0.1766
Schistosoma mansoni tubulin subunit epsilon 0.0047 0.0093 0.0642
Echinococcus multilocularis epidermal growth factor receptor 0.0296 0.1034 0.1121
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0042 0.035
Plasmodium vivax hypothetical protein, conserved 0.0188 0.0627 0.2348
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0032 0.0036 0.1453
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Schistosoma mansoni hypothetical protein 0.0083 0.023 0.1678
Loa Loa (eye worm) tubulin beta-1 chain 0.0047 0.0093 0.064
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.0159 0.1329
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0188 0.0627 0.2348
Echinococcus granulosus tubulin beta 1 chain 0.0047 0.0093 0.0781
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0719 0.2631 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0186 0.0191
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0047 0.0093 0.0101
Brugia malayi beta-tubulin, identical 0.0047 0.0093 0.0119
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0029 0.0028 0.0062
Onchocerca volvulus 0.0374 0.1329 0.1342
Echinococcus granulosus insulin receptor 0.0095 0.0273 0.2291
Schistosoma mansoni hypothetical protein 0.0037 0.0056 0.0363
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0025 0.0027
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Loa Loa (eye worm) RNA binding protein 0.013 0.0406 0.3009
Brugia malayi Tubulin alpha-2 chain 0.0087 0.0245 0.0331
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0719 0.2631 1
Trypanosoma cruzi beta tubulin, putative 0.0047 0.0093 0.0337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0448 0.3753
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0186 0.0666
Echinococcus granulosus expressed conserved protein 0.0189 0.0629 0.527
Leishmania major gamma-tubulin 0.0047 0.0093 0.0337
Schistosoma mansoni transient receptor potential channel 0.0097 0.0282 0.2074
Schistosoma mansoni alpha tubulin 0.0087 0.0245 0.179
Loa Loa (eye worm) tubulin gamma chain 0.0047 0.0093 0.064
Echinococcus multilocularis tubulin subunit TubB 0.0087 0.0245 0.0266
Loa Loa (eye worm) hypothetical protein 0.0087 0.0245 0.1788
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Entamoeba histolytica tubulin alpha chain, putative 0.0087 0.0245 0.3585
Loa Loa (eye worm) hypothetical protein 0.0031 0.0033 0.0184
Entamoeba histolytica tubulin family protein 0.0047 0.0093 0.1322
Plasmodium vivax telomerase reverse transcriptase, putative 0.0719 0.2631 1
Leishmania major hypothetical protein, conserved 0.0025 0.0011 0.0026
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0186 0.069
Loa Loa (eye worm) BEN-1 protein 0.0047 0.0093 0.064
Echinococcus multilocularis Tubulin alpha 1 chain 0.0087 0.0245 0.0266
Trichomonas vaginalis tubulin beta chain, putative 0.0087 0.0245 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0009 0.0016
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0029 0.0028 0.0088
Trichomonas vaginalis tubulin beta chain, putative 0.0087 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0021
Trichomonas vaginalis tubulin beta chain, putative 0.0087 0.0245 1
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0028 0.0233
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0641 0.2336 0.233
Loa Loa (eye worm) hypothetical protein 0.0067 0.0168 0.1207
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Trichomonas vaginalis tubulin beta chain, putative 0.0087 0.0245 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0047 0.0093 0.0101
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0028 0.003
Loa Loa (eye worm) hypothetical protein 0.0072 0.0187 0.1351
Trichomonas vaginalis tubulin, putative 0.0026 0.0016 0.0672
Loa Loa (eye worm) hypothetical protein 0.006 0.0145 0.1031
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0031 0.0033 0.0277
Brugia malayi ABC transporter family protein 0.0032 0.0036 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0086 0.0242 0.9877
Trichomonas vaginalis tubulin, putative 0.0026 0.0016 0.0672
Trypanosoma cruzi tubulin gamma chain 0.0047 0.0093 0.0337
Trichomonas vaginalis tubulin gamma chain, putative 0.0047 0.0093 0.3806
Brugia malayi Kinesin motor domain containing protein 0.0026 0.0015 0.0009
Onchocerca volvulus 0.0071 0.0186 0.018
Entamoeba histolytica kinesin, putative 0.0026 0.0015 0.016
Echinococcus multilocularis Tubulin beta 2C chain 0.0047 0.0093 0.0101
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0009 0.0061
Leishmania major hypothetical protein, conserved 0.0071 0.0186 0.069
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Trypanosoma brucei alpha tubulin, putative 0.0026 0.0016 0.0019
Plasmodium falciparum multidrug resistance protein 1 0.0032 0.0036 0.0092
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0036 0.1453
Loa Loa (eye worm) beta-lactamase 0.0071 0.0186 0.1341
Brugia malayi hypothetical protein 0.0037 0.0056 0.0067
Onchocerca volvulus 0.0032 0.0036 0.0027
Schistosoma mansoni tubulin subunit gamma 0.0047 0.0093 0.0642
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0036 0.1453
Echinococcus multilocularis beta tubulin 0.0047 0.0093 0.0101
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0042 0.0046
Plasmodium falciparum protoporphyrinogen oxidase 0.0188 0.0627 0.2348
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Plasmodium vivax importin-beta 2, putative 0.0029 0.0025 0.0052
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.027 0.2265
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0448 0.3753
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0032 0.0036 0.1453
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.1077 0.8091
Echinococcus multilocularis ATP binding cassette sub family B 0.0031 0.0033 0.0036
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0036 0.0298
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.006 0.0145 0.5916
Mycobacterium ulcerans monoamine oxidase 0.0188 0.0627 0.0618
Mycobacterium tuberculosis Conserved protein 0.0071 0.0186 0.0191
Leishmania major p-glycoprotein 0.0032 0.0036 0.0118
Echinococcus granulosus tubulin alpha chain 0.0087 0.0245 0.2052
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0011 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0009 0.0016
Echinococcus granulosus tubulin subunit TubB 0.0087 0.0245 0.2052
Echinococcus multilocularis tubulin gamma 1 chain 0.0047 0.0093 0.0101
Schistosoma mansoni tyrosine kinase 0.0157 0.051 0.3799
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0032 0.0036 0.0092
Loa Loa (eye worm) hypothetical protein 0.0033 0.004 0.024
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0036 0.1453
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0186 0.0191
Onchocerca volvulus 0.0071 0.0186 0.018
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0282 0.0306
Giardia lamblia Alpha-tubulin 0.0087 0.0245 0.0878
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Trypanosoma cruzi ABC transporter, putative 0.0029 0.0028 0.0088
Trypanosoma brucei beta tubulin 0.0047 0.0093 0.0312
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0053 0.0062
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0186 0.7589
Plasmodium falciparum kinesin-5 0.0026 0.0015 0.0015
Echinococcus granulosus snurportin 1 0.0307 0.1077 0.9029
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0374 0.1329 0.1852
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0188 0.0627 0.0618
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0159 0.0517 0.433
Echinococcus granulosus Tubulin beta 2C chain 0.0047 0.0093 0.0781
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.2482 0.929 1
Entamoeba histolytica hypothetical protein 0.0037 0.0056 0.0773
Schistosoma mansoni tubulin subunit beta 0.0047 0.0093 0.0642
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0374 0.1329 0.1852
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0159 0.0172
Trypanosoma brucei beta tubulin 0.0047 0.0093 0.0312
Plasmodium vivax tubulin alpha chain, putative 0.0087 0.0245 0.0891
Schistosoma mansoni tar DNA-binding protein 0.013 0.0406 0.301
Loa Loa (eye worm) hypothetical protein 0.0071 0.0186 0.1341
Echinococcus multilocularis protein patched 0.0086 0.0242 0.0262
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0188 0.0627 0.2348
Plasmodium falciparum telomerase reverse transcriptase 0.0719 0.2631 1
Entamoeba histolytica hypothetical protein 0.0037 0.0056 0.0773
Schistosoma mansoni tyrosine kinase 0.0157 0.051 0.3799
Schistosoma mansoni hypothetical protein 0.0338 0.1193 0.8969
Trichomonas vaginalis tubulin beta chain, putative 0.0026 0.0016 0.0672
Trichomonas vaginalis tubulin gamma chain, putative 0.0047 0.0093 0.3806
Trypanosoma brucei epsilon tubulin 0.0047 0.0093 0.0312
Schistosoma mansoni importin beta-1 0.0029 0.0025 0.0127
Plasmodium vivax kinesin-5 0.0026 0.0015 0.0015
Trypanosoma brucei epsilon tubulin 0.0047 0.0093 0.0312
Echinococcus granulosus tubulin epsilon chain 0.0047 0.0093 0.0781
Schistosoma mansoni amine oxidase 0.0188 0.0627 0.4679
Schistosoma mansoni kinesin eg-5 0.0026 0.0015 0.0052
Leishmania major epsilon tubulin, putative 0.0047 0.0093 0.0337
Brugia malayi multidrug resistance protein 3 0.0032 0.0036 0.0038
Echinococcus multilocularis beta tubulin 0.0047 0.0093 0.0101
Echinococcus multilocularis protein dispatched 1 0.0098 0.0288 0.0312
Echinococcus multilocularis tubulin alpha 3 chain 0.0087 0.0245 0.0266
Entamoeba histolytica P-glycoprotein-1 0.0032 0.0036 0.0462
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Entamoeba histolytica tubulin gamma chain 0.0047 0.0093 0.1322
Echinococcus granulosus multidrug resistance protein 1 0.0032 0.0036 0.0298
Loa Loa (eye worm) hypothetical protein 0.0071 0.0186 0.1341
Echinococcus granulosus alpha tubulin 0.0087 0.0245 0.2052
Schistosoma mansoni tubulin subunit beta 0.0047 0.0093 0.0642
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.0159 0.0172
Loa Loa (eye worm) TK/INSR protein kinase 0.0095 0.0273 0.2004
Echinococcus multilocularis tubulin alpha chain 0.0087 0.0245 0.0266
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0028 0.0233
Trichomonas vaginalis tubulin beta chain, putative 0.0087 0.0245 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.0312 0.0426
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0042 0.035
Leishmania major alpha tubulin 0.0087 0.0245 0.0915
Brugia malayi RNA binding protein 0.013 0.0406 0.0557
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0042 0.0046
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0067 0.0168 0.6866
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0032 0.0036 0.0298
Trichomonas vaginalis tubulin alpha chain, putative 0.0047 0.0093 0.3806
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0186 0.7589
Schistosoma mansoni hypothetical protein 0.0307 0.1077 0.8092
Loa Loa (eye worm) hypothetical protein 0.0071 0.0186 0.1341
Schistosoma mansoni hypothetical protein 0.0083 0.023 0.1678
Schistosoma mansoni smdr2 0.0032 0.0036 0.0205
Schistosoma mansoni tyrosine kinase 0.0157 0.051 0.3799
Echinococcus granulosus importin subunit beta 1 0.0029 0.0025 0.0211
Echinococcus multilocularis tubulin alpha chain 0.0087 0.0245 0.0266
Echinococcus granulosus Tubulin beta 2C chain 0.0047 0.0093 0.0781
Schistosoma mansoni patched 1 0.0086 0.0242 0.1767
Schistosoma mansoni hypothetical protein 0.0033 0.0042 0.0252
Leishmania major beta tubulin 0.0047 0.0093 0.0337
Entamoeba histolytica fatty acid elongase, putative 0.0083 0.0231 0.3374
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0186 0.069
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0186 0.1343
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0009 0.0016
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0036 0.1453
Trichomonas vaginalis ABC transporter, putative 0.0032 0.0036 0.1453
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0056 0.0061
Loa Loa (eye worm) hypothetical protein 0.0374 0.1329 1
Loa Loa (eye worm) tubulin beta chain 0.0047 0.0093 0.064
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.027 0.0293
Schistosoma mansoni tubulin subunit beta 0.0047 0.0093 0.0642
Entamoeba histolytica ABC transporter, putative 0.0029 0.0028 0.0345
Trypanosoma cruzi epsilon tubulin, putative 0.0047 0.0093 0.0337
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0032 0.0036 0.1453
Echinococcus granulosus tubulin beta 4A class IVa 0.0047 0.0093 0.0781
Echinococcus multilocularis Tubulin beta 2C chain 0.0047 0.0093 0.0101

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1032 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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