Detailed information for compound 1451506

Basic information

Technical information
  • TDR Targets ID: 1451506
  • Name: 2-tert-butylsulfanyl-6-hydroxy-3H-pyrimidin-4 -one
  • MW: 200.258 | Formula: C8H12N2O2S
  • H donors: 2 H acceptors: 4 LogP: 1.99 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Sc1nc(O)cc(n1)O)(C)C
  • InChi: 1S/C8H12N2O2S/c1-8(2,3)13-7-9-5(11)4-6(12)10-7/h4H,1-3H3,(H2,9,10,11,12)
  • InChiKey: YGWGHZWZKSCWIQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(tert-butylthio)-6-hydroxy-3H-pyrimidin-4-one
  • MLS000039862
  • STOCK3S-93814
  • SMR000058025

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus smad 0.005 0.0092 0.0458
Loa Loa (eye worm) hypothetical protein 0.0123 0.0592 0.0566
Brugia malayi Calcitonin receptor-like protein seb-1 0.0902 0.5978 0.5972
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0071 0.0234 0.4328
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0624 0.1527
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0902 0.5978 0.5966
Mycobacterium ulcerans Type I modular polyketide synthase 0.0073 0.0249 0.4065
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0073 0.025 0.0223
Loa Loa (eye worm) Smad1 0.005 0.0092 0.0065
Brugia malayi hypothetical protein 0.0073 0.025 0.0236
Loa Loa (eye worm) hypothetical protein 0.1484 1 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0078 0.0281 0.481
Brugia malayi RasGEF domain containing protein 0.0052 0.0105 0.0091
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0052 0.0105 0.0531
Loa Loa (eye worm) hypothetical protein 0.0073 0.025 0.0223
Echinococcus multilocularis mothers against decapentaplegic 5 0.005 0.0092 0.0458
Echinococcus multilocularis GPCR, family 2 0.0285 0.1717 1
Schistosoma mansoni ras GTP exchange factor 0.0052 0.0105 0.0227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0069 0.0319
Loa Loa (eye worm) fatty acid synthase 0.0072 0.0243 0.0216
Mycobacterium ulcerans polyketide synthase 0.0078 0.0281 0.481
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0068 0.0216 0.395
Trichomonas vaginalis ras GTP exchange factor, putative 0.0052 0.0105 0.5
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0052 0.0105 0.0227
Brugia malayi N-terminal motif family protein 0.0052 0.0105 0.0091
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0078 0.0281 0.533
Loa Loa (eye worm) RasGEF domain-containing protein 0.0052 0.0105 0.0077
Schistosoma mansoni dishevelled 0.0073 0.025 0.059
Brugia malayi Choline O-acetyltransferase 0.0045 0.0055 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0068 0.0216 0.0202
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0069 0.0096
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0045 0.0055 0.0028
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0052 0.0105 0.0531
Loa Loa (eye worm) hypothetical protein 0.0045 0.0055 0.0028
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0045 0.0055 0.0241
Echinococcus multilocularis ras GTP exchange factor 0.0052 0.0105 0.0531
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0068 0.0216 0.0189
Mycobacterium leprae Polyketide synthase Pks13 0.0109 0.0499 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0073 0.0249 0.4659
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0069 0.0319
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0059 0.0151 0.172
Echinococcus granulosus TGF beta signal transducer SmadC 0.005 0.0092 0.0458
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0052 0.0105 0.0358
Brugia malayi Choline O-acetyltransferase 0.0045 0.0055 0.0041
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0078 0.0281 0.481
Schistosoma mansoni TGF-beta signal transducer Smad2 0.005 0.0092 0.0195
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0624 0.3578
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0073 0.025 0.0195
Echinococcus multilocularis segment polarity protein dishevelled 0.0073 0.025 0.1382
Echinococcus granulosus GPCR family 2 0.0285 0.1717 1
Echinococcus multilocularis choline O acetyltransferase 0.0045 0.0055 0.0241
Trypanosoma cruzi hypothetical protein 0.0052 0.0105 0.0358
Schistosoma mansoni hypothetical protein 0.0285 0.1717 0.4266
Loa Loa (eye worm) hypothetical protein 0.0285 0.1717 0.1694
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0073 0.0249 0.4659
Brugia malayi TAR-binding protein 0.0127 0.0624 0.061
Brugia malayi hypothetical protein 0.0073 0.025 0.0236
Echinococcus multilocularis smad 0.005 0.0092 0.0458
Onchocerca volvulus 0.0127 0.0623 0.0571
Brugia malayi MH1 domain containing protein 0.005 0.0092 0.0078
Echinococcus granulosus segment polarity protein dishevelled 0.0073 0.025 0.1382
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0069 0.0136
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0069 0.2447
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0078 0.0281 0.481
Onchocerca volvulus 0.0073 0.025 0.0195
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0285 0.1717 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0073 0.025 0.0236
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0069 0.0613
Loa Loa (eye worm) hypothetical protein 0.0617 0.4006 0.3989
Entamoeba histolytica hypothetical protein 0.0052 0.0105 1
Echinococcus multilocularis Protein son of sevenless 0.0052 0.0105 0.0531
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0078 0.0281 0.481
Toxoplasma gondii type I fatty acid synthase, putative 0.0052 0.0104 0.3708
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0272 0.9671
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0624 0.0598
Brugia malayi regulator of G-protein signaling egl-10 0.0073 0.025 0.0236
Echinococcus multilocularis Smad4 0.005 0.0092 0.0458
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0069 0.0319
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0138 0.0701 0.0688
Brugia malayi latrophilin 2 splice variant baaae 0.0617 0.4006 0.3997
Loa Loa (eye worm) latrophilin receptor protein 2 0.0285 0.1717 0.1694
Brugia malayi MH2 domain containing protein 0.0738 0.4842 0.4834
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0073 0.0249 0.4065
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0045 0.0055 0.0041
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0052 0.0105 0.0227
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0071 0.0234 0.4328
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0078 0.0281 0.533
Loa Loa (eye worm) hypothetical protein 0.0052 0.0105 0.0077
Brugia malayi RNA binding protein 0.0127 0.0624 0.061
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Mycobacterium ulcerans thioesterase 0.0061 0.0165 0.2064
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0052 0.0105 0.0531
Leishmania major hypothetical protein, conserved 0.0076 0.0272 0.1564
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0069 0.0319
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0285 0.1717 1
Schistosoma mansoni smad 0.005 0.0092 0.0195
Brugia malayi Latrophilin receptor protein 2 0.0285 0.1717 0.1705
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0073 0.025 0.059
Schistosoma mansoni choline o-acyltransferase 0.0045 0.0055 0.0103
Mycobacterium tuberculosis Probable thioesterase TesA 0.0061 0.0165 0.2859
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Loa Loa (eye worm) transcription factor SMAD2 0.0738 0.4842 0.4827
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.006 0.0158 0.2692
Mycobacterium ulcerans polyketide synthase 0.0073 0.0249 0.4065
Brugia malayi DIX domain containing protein 0.0073 0.025 0.0236
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0272 1
Toxoplasma gondii hypothetical protein 0.0073 0.025 0.8896
Loa Loa (eye worm) hypothetical protein 0.0073 0.025 0.0223
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0052 0.0105 0.005
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0052 0.0107 0.1618
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0245 0.1437 1
Schistosoma mansoni choline o-acyltransferase 0.0045 0.0055 0.0103
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0272 0.1564
Trichomonas vaginalis ras GTP exchange factor, putative 0.0052 0.0105 0.5
Schistosoma mansoni dishevelled 0.0073 0.025 0.059
Echinococcus granulosus ras GTP exchange factor 0.0052 0.0105 0.0531
Schistosoma mansoni dep domain containing protein 0.0073 0.025 0.059
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0285 0.1717 0.1705
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0073 0.0249 0.4659
Loa Loa (eye worm) RasGEF domain-containing protein 0.0052 0.0105 0.0077
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0052 0.0105 0.0227
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0245 0.1437 0.8357
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0109 0.0499 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0738 0.4842 0.4827
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Brugia malayi isocitrate dehydrogenase 0.0047 0.0069 0.0054
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0272 1
Echinococcus granulosus segment polarity protein dishevelled 0.0073 0.025 0.1382
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0073 0.0249 0.4065
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0069 0.0613
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0624 0.1527
Mycobacterium ulcerans polyketide synthase Pks13 0.0109 0.0499 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0059 0.0151 0.172
Loa Loa (eye worm) hypothetical protein 0.0431 0.2725 0.2705
Schistosoma mansoni smad1 5 8 and 0.005 0.0092 0.0195
Schistosoma mansoni smad1 5 8 and 0.005 0.0092 0.0195
Brugia malayi hypothetical protein 0.0076 0.0272 0.0258
Schistosoma mansoni Smad4 0.005 0.0092 0.0195
Loa Loa (eye worm) hypothetical protein 0.0073 0.025 0.0223
Loa Loa (eye worm) choline O-acetyltransferase 0.0045 0.0055 0.0028
Brugia malayi MH2 domain containing protein 0.005 0.0092 0.0078
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0073 0.0249 0.0235
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0073 0.0249 0.4065
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0624 0.1527
Echinococcus multilocularis segment polarity protein dishevelled 0.0073 0.025 0.1382
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0245 0.1437 1
Loa Loa (eye worm) DIX domain-containing protein 0.0073 0.025 0.0223
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0061 0.0165 0.2064
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.005 0.0087 0.0183
Onchocerca volvulus Fatty acid synthase homolog 0.0132 0.0654 0.0602
Echinococcus multilocularis regulator of G protein signaling 7 0.0073 0.025 0.1382
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0624 0.0598
Toxoplasma gondii type I fatty acid synthase, putative 0.0078 0.0281 1
Mycobacterium leprae Probable polyketide synthase Pks1 0.0078 0.0281 0.481
Echinococcus multilocularis TGF beta signal transducer SmadC 0.005 0.0092 0.0458
Echinococcus granulosus regulator of G protein signaling 7 0.0073 0.025 0.1382
Loa Loa (eye worm) hypothetical protein 0.0076 0.0272 0.0245
Mycobacterium ulcerans Type I modular polyketide synthase 0.0073 0.0249 0.4065
Schistosoma mansoni hypothetical protein 0.0285 0.1717 0.4266
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0069 0.0096
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0069 0.0319
Mycobacterium ulcerans thioesterase TesA 0.0061 0.0165 0.2064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0902 0.5978 0.5972
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0272 1
Brugia malayi RasGEF domain containing protein 0.0052 0.0105 0.0091
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0069 0.2447
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0272 0.1564
Brugia malayi Smad1 0.005 0.0092 0.0078
Echinococcus granulosus son of sevenless 1 0.0052 0.0105 0.0531
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0624 0.1527
Schistosoma mansoni smad1 5 8 and 0.005 0.0092 0.0195
Loa Loa (eye worm) MH2 domain-containing protein 0.005 0.0092 0.0065
Brugia malayi N-terminal motif family protein 0.0052 0.0105 0.0091
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0431 0.2725 0.2715
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0245 0.1437 0.8357
Echinococcus granulosus regulator of G protein signaling 7 0.0073 0.025 0.1382
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0069 0.0054
Schistosoma mansoni hypothetical protein 0.0285 0.1717 0.4266
Loa Loa (eye worm) RasGEF domain-containing protein 0.0052 0.0105 0.0077
Schistosoma mansoni z-protein (S1r protein) 0.0073 0.025 0.059
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0624 0.061
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0069 0.0319
Echinococcus granulosus choline O acetyltransferase 0.0045 0.0055 0.0241
Loa Loa (eye worm) hypothetical protein 0.0052 0.0105 0.0077
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0045 0.0055 0.0041
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.1484 1 1
Echinococcus granulosus tar DNA binding protein 0.0127 0.0624 0.3578
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0069 0.0041
Trypanosoma cruzi hypothetical protein 0.0052 0.0105 0.0358
Echinococcus granulosus Pleckstrin G protein interacting region 0.0073 0.025 0.1382
Brugia malayi hypothetical protein 0.0049 0.0085 0.0071
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0052 0.0105 0.0531
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0069 0.0789
Onchocerca volvulus 0.0052 0.0105 0.005
Echinococcus multilocularis son of sevenless 1 0.0052 0.0105 0.0531
Brugia malayi MH2 domain containing protein 0.005 0.0092 0.0078
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0045 0.0055 0.0028
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0245 0.1437 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0047 0.0072 0.2574
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0272 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0073 0.025 0.1382
Brugia malayi MH1 domain containing protein 0.005 0.0092 0.0078
Schistosoma mansoni regulator of G protein signaling 0.0073 0.025 0.059
Loa Loa (eye worm) MH1 domain-containing protein 0.005 0.0092 0.0065
Schistosoma mansoni hypothetical protein 0.0285 0.1717 0.4266
Echinococcus granulosus mothers against decapentaplegic 5 0.005 0.0092 0.0458
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0285 0.1717 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0069 0.0096
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0078 0.0281 0.533
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0052 0.0105 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0059 0.0151 0.172
Mycobacterium ulcerans Type I modular polyketide synthase 0.0073 0.0249 0.4065
Echinococcus granulosus Protein son of sevenless 0.0052 0.0105 0.0531
Loa Loa (eye worm) RNA binding protein 0.0127 0.0624 0.0598
Onchocerca volvulus 0.0068 0.0216 0.0162
Brugia malayi RasGEF domain containing protein 0.0052 0.0105 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0624 0.1527
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0045 0.0055 0.0241
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0073 0.025 0.0236
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0052 0.0105 0.0227
Echinococcus granulosus Smad4 0.005 0.0092 0.0458
Echinococcus multilocularis regulator of G protein signaling 7 0.0073 0.025 0.1382
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Schistosoma mansoni hypothetical protein 0.0617 0.4006 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0285 0.1717 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0109 0.0499 1
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0052 0.0105 0.5
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0052 0.0105 1
Loa Loa (eye worm) hypothetical protein 0.0902 0.5978 0.5966

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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