Detailed information for compound 1453582

Basic information

Technical information
  • TDR Targets ID: 1453582
  • Name: 1-thiophen-2-ylsulfonylpyrazole
  • MW: 214.265 | Formula: C7H6N2O2S2
  • H donors: 0 H acceptors: 3 LogP: 1.48 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S(=O)(c1cccs1)n1cccn1
  • InChi: 1S/C7H6N2O2S2/c10-13(11,7-3-1-6-12-7)9-5-2-4-8-9/h1-6H
  • InChiKey: ISGASCAITPUQMX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-thienylsulfonyl)pyrazole
  • BAS 08205917
  • ChemDiv2_002590
  • SMR000014829
  • 1-(Thiophene-2-sulfonyl)-1H-pyrazole
  • MLS000030604

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens pyruvate kinase, muscle Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus granulosus pyruvate kinase pyruvate kinase, muscle 605 aa 521 aa 34.9 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii pyruvate kinase PyKII 0.0021 0.005 0.1876
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0052 0.0375
Echinococcus multilocularis expressed protein 0.0037 0.0126 0.0126
Entamoeba histolytica hypothetical protein 0.0026 0.0074 0.015
Echinococcus granulosus expressed protein 0.0037 0.0126 0.0126
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0144 0.572
Schistosoma mansoni hypothetical protein 0.0447 0.2097 0.2097
Echinococcus granulosus cpg binding protein 0.0035 0.012 0.012
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0144 0.0137
Brugia malayi hypothetical protein 0.0165 0.0744 0.0737
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0074 0.0529
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0122 0.6488
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0074 0.2502
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0052 0.2641
Loa Loa (eye worm) hypothetical protein 0.0045 0.0165 0.0122
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0074 0.3821
Mycobacterium leprae cell division protein FtsZ 0.03 0.139 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0387 0.0387
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0144 0.0662
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0000077891
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0144 0.0662
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0139 0.0139
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0052 0.0052
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1484 1
Echinococcus multilocularis cpg binding protein 0.0035 0.012 0.012
Echinococcus granulosus pyruvate kinase 0.0021 0.005 0.005
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0144 0.0662
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.07 0.5037
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0052 0.2641
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.004 0.004
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0144 0.0468
Loa Loa (eye worm) glutaminase 2 0.0299 0.1385 0.1349
Echinococcus multilocularis pyruvate kinase 0.004 0.0144 0.0144
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0122 0.6488
Treponema pallidum cell division protein FtsZ 0.03 0.139 0.9363
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1484 1
Giardia lamblia Pyruvate kinase 0.004 0.0144 0.0656
Echinococcus multilocularis dnaJ subfamily B 0.0447 0.2097 0.2097
Echinococcus granulosus pyruvate kinase 0.004 0.0144 0.0144
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0144 0.7703
Giardia lamblia DINP protein human, muc B family 0.0021 0.0052 0.0015
Trypanosoma brucei pyruvate kinase 1 0.004 0.0144 0.7703
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Loa Loa (eye worm) hypothetical protein 0.0091 0.0385 0.0344
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0052 0.0052
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0052 0.0351
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0074 0.3821
Plasmodium falciparum pyruvate kinase 0.004 0.0144 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Schistosoma mansoni DNA polymerase eta 0.0049 0.0186 0.0186
Onchocerca volvulus 0.0091 0.0387 0.4447
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0074 0.0529
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Echinococcus multilocularis pyruvate kinase 0.0021 0.005 0.005
Schistosoma mansoni pyruvate kinase 0.0021 0.005 0.005
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0144 0.0971
Loa Loa (eye worm) hypothetical protein 0.0165 0.0744 0.0704
Echinococcus multilocularis pyruvate kinase 0.0021 0.005 0.005
Schistosoma mansoni zinc finger protein 0.0023 0.0062 0.0062
Schistosoma mansoni cpg binding protein 0.0035 0.012 0.012
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0102 0.0058
Echinococcus multilocularis dna polymerase eta 0.0049 0.0186 0.0186
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0086 0.0042
Leishmania major DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Leishmania major pyruvate kinase 0.004 0.0144 0.7703
Leishmania major DNA polymerase eta, putative 0.0049 0.0186 1
Leishmania major hypothetical protein, conserved 0.0017 0.0031 0.1486
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0074 0.0529
Schistosoma mansoni hypothetical protein 0.0091 0.0385 0.0385
Brugia malayi ImpB/MucB/SamB family protein 0.0049 0.0186 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Echinococcus multilocularis pyruvate kinase 0.0032 0.0103 0.0103
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1484 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0139 0.0139
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0091 0.0385 0.0385
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.03 0.139 1
Echinococcus multilocularis pyruvate kinase 0.0021 0.005 0.005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0052 0.0009
Schistosoma mansoni pyruvate kinase 0.004 0.0144 0.0144
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0052 0.0045
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0634 0.2992 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0044 0.0044
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0144 0.1037
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0144 0.1037
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0052 0.0161
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1484 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0021 0.0911
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0074 0.0529
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0091 0.0385 0.0385
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0052 0.2641
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0021 0.0911
Plasmodium vivax pyruvate kinase, putative 0.004 0.0144 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.0102 0.0095
Echinococcus granulosus pyruvate kinase 0.004 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0017 0.0031 0.0031
Trypanosoma brucei ISWI complex protein 0.0017 0.0031 0.1486
Loa Loa (eye worm) glutaminase 0.0299 0.1385 0.1349
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0078 0.0078
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0052 0.0161
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0052 0.0052
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0387 0.0387
Trypanosoma brucei DNA polymerase eta, putative 0.0049 0.0186 1
Schistosoma mansoni hypothetical protein 0.0091 0.0385 0.0385
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.07 0.5037
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Trypanosoma cruzi DNA polymerase eta, putative 0.0049 0.0186 0.0608
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0086 0.0234
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0078 0.0078
Loa Loa (eye worm) pyruvate kinase 0.004 0.0144 0.0101
Echinococcus multilocularis zinc finger protein 0.0023 0.0062 0.0062
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0144 0.0137
Brugia malayi Bromodomain containing protein 0.0042 0.0152 0.0145
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0273 0.0273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1484 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0074 0.2502
Trypanosoma cruzi ISWI complex protein 0.0017 0.0031 0.009
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0091 0.0385 0.0385
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0052 0.0375
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0249 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0387 0.0345
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1484 1
Schistosoma mansoni protein kinase 0.2096 1 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0074 0.2837
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0387 0.0387
Brugia malayi Cell division protein ftsZ 0.0148 0.0661 0.0654
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.004 0.004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.1484 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0086 0.0042
Giardia lamblia Fructose-bisphosphate aldolase 0.032 0.1484 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.027 0.027
Trypanosoma brucei DNA polymerase kappa, putative 0.0015 0.0021 0.0911
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.07 0.5037
Loa Loa (eye worm) STE/STE11/ASK protein kinase 0.0634 0.2992 0.2966
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0122 0.0394
Leishmania major DNA polymerase eta, putative 0.0034 0.0116 0.6155
Brugia malayi PHD-finger family protein 0.0029 0.009 0.0083
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0052 0.0052
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0074 0.0496
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0273 0.0273
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0122 0.0394
Schistosoma mansoni apoptosis regulator bax 0.0091 0.0385 0.0385
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.004 0.004
Loa Loa (eye worm) apoptosis regulator protein 0.0091 0.0385 0.0344
Schistosoma mansoni bromodomain containing protein 0.0071 0.0291 0.0291
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0074 0.0529
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0122 0.4817
Echinococcus granulosus dna polymerase eta 0.0049 0.0186 0.0186
Trypanosoma brucei unspecified product 0.0015 0.0021 0.0911
Loa Loa (eye worm) hypothetical protein 0.0048 0.0183 0.014
Schistosoma mansoni cpg binding protein 0.0035 0.012 0.012
Echinococcus granulosus dna polymerase kappa 0.0021 0.0052 0.0052
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0009 0.0002
Trichomonas vaginalis rotamase, putative 0.0036 0.0122 0.0822
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0144 0.0468
Trichomonas vaginalis glutaminase, putative 0.0299 0.1385 0.9332
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0.0004 0.003
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0126 0.0083
Trypanosoma brucei unspecified product 0.0015 0.0021 0.0911
Leishmania major pyruvate kinase 0.004 0.0144 0.7703
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0126 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Schistosoma mansoni glutaminase 0.0299 0.1385 0.1385
Brugia malayi Cell division protein ftsZ 0.0144 0.0641 0.0635
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0052 0.0351
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0052 0.2641
Loa Loa (eye worm) hypothetical protein 0.0049 0.0186 0.0143
Echinococcus multilocularis pyruvate kinase 0.004 0.0144 0.0144
Chlamydia trachomatis pyruvate kinase 0.004 0.0144 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0091 0.0385 0.0379
Onchocerca volvulus 0.0165 0.0744 1
Loa Loa (eye worm) hypothetical protein 0.2093 0.9985 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0322 0.028
Loa Loa (eye worm) pyruvate kinase 0.004 0.0144 0.0101
Echinococcus granulosus pyruvate kinase 0.0021 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.004 0.0144 0.0101
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Brugia malayi glutaminase DH11.1 0.0299 0.1385 0.1379
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0387 0.038
Echinococcus granulosus zinc finger protein 0.0023 0.0062 0.0062
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0091 0.0385 0.0385
Mycobacterium ulcerans glutaminase 0.0299 0.1385 0.9967
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0144 0.0971
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.032 0.1484 1
Schistosoma mansoni protein kinase 0.2096 1 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.004 0.004
Brugia malayi Bromodomain containing protein 0.0084 0.0353 0.0346
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.2096 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0052 0.0375
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.2096 1 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0634 0.2992 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0126 0.085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0044 0.0044
Schistosoma mansoni pyruvate kinase 0.004 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0631 0.2977 0.295
Trichomonas vaginalis rotamase, putative 0.0037 0.0126 0.085
Trypanosoma cruzi DNA polymerase eta, putative 0.0034 0.0116 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1484 1
Schistosoma mansoni zinc finger protein 0.0017 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Echinococcus granulosus pyruvate kinase 0.0021 0.005 0.005
Mycobacterium ulcerans cell division protein FtsZ 0.03 0.139 1
Schistosoma mansoni hypothetical protein 0.0023 0.0059 0.0059
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0059 0.0016
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0044 0.0044
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0091 0.0385 0.0385
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0052 0.0161
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0052 0.0052
Mycobacterium ulcerans pyruvate kinase 0.004 0.0144 0.1037
Trypanosoma brucei unspecified product 0.0021 0.0052 0.2641
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0044 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Trypanosoma cruzi ISWI complex protein 0.0017 0.0031 0.009
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0122 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0052 0.2641
Schistosoma mansoni rotamase 0.0037 0.0126 0.0126
Treponema pallidum fructose-bisphosphate aldolase 0.032 0.1484 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0074 0.2837
Loa Loa (eye worm) pyruvate kinase 0.004 0.0144 0.0101
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0116 0.457
Schistosoma mansoni hypothetical protein 0.0091 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0042 0.0152 0.0109
Mycobacterium tuberculosis Cell division protein FtsZ 0.03 0.139 1
Echinococcus granulosus dnaJ subfamily B 0.0447 0.2097 0.2097
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0052 0.0161
Schistosoma mansoni cpg binding protein 0.0031 0.0102 0.0102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.032 0.1484 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0052 0.0375

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ] ChEMBL. No reference
Potency (binding) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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