Detailed information for compound 1454337

Basic information

Technical information
  • TDR Targets ID: 1454337
  • Name: 2-(2-chlorophenoxy)-N-[2-[(7-methyl-4-oxopyri do[1,2-a]pyrimidin-2-yl)methoxy]phenyl]acetam ide
  • MW: 449.886 | Formula: C24H20ClN3O4
  • H donors: 1 H acceptors: 2 LogP: 3.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1OCc1cc(=O)n2c(n1)ccc(c2)C)COc1ccccc1Cl
  • InChi: 1S/C24H20ClN3O4/c1-16-10-11-22-26-17(12-24(30)28(22)13-16)14-31-21-9-5-3-7-19(21)27-23(29)15-32-20-8-4-2-6-18(20)25/h2-13H,14-15H2,1H3,(H,27,29)
  • InChiKey: WLVOFEDVTLRQSR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-(2-chlorophenoxy)-N-[2-[(7-methyl-4-oxo-pyrido[1,2-a]pyrimidin-2-yl)methoxy]phenyl]acetamide
  • 2-(2-chlorophenoxy)-N-[2-[(7-methyl-4-oxo-2-pyrido[1,2-a]pyrimidinyl)methoxy]phenyl]acetamide
  • 2-(2-chlorophenoxy)-N-[2-[(4-keto-7-methyl-pyrido[1,2-a]pyrimidin-2-yl)methoxy]phenyl]acetamide
  • 2-(2-chlorophenoxy)-N-[2-[(7-methyl-4-oxo-pyrido[1,2-a]pyrimidin-2-yl)methoxy]phenyl]ethanamide
  • G756-1328
  • NCGC00133803-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0037 0.0082
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0028 0.0067
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0039 0.0039
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0152 0.0167 0.0392
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0088 0.0091 0.9015
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0003 0.0003
Brugia malayi jmjC domain containing protein 0.0035 0.0028 0.0063
Mycobacterium tuberculosis Conserved protein 0.0096 0.0101 0.0227
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0088 0.0091 0.0218
Trichomonas vaginalis PIKK family atypical protein kinase 0.0057 0.0055 0.1011
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0071 0.0071 0.0071
Toxoplasma gondii exonuclease III APE 0.004 0.0034 0.0065
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0223 0.0251 0.0251
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0058 0.0058
Echinococcus granulosus neuropeptide s receptor 0.0544 0.0632 0.0632
Toxoplasma gondii CBS family protein 0.0096 0.0101 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0091 0.1687
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0223 0.0251 0.06
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0223 0.0251 0.0251
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0011 0.002
Echinococcus granulosus lamin 0.0026 0.0019 0.0019
Mycobacterium tuberculosis Probable hydrolase 0.0223 0.0251 0.0586
Schistosoma mansoni hypothetical protein 0.048 0.0555 0.0555
Trichomonas vaginalis penicillin-binding protein, putative 0.0223 0.0251 0.4656
Brugia malayi nuclear receptor NHR-88 0.002 0.0011 0.002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0099 0.0105 0.0217
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0223 0.0251 0.06
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0031
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0096 0.0101 0.0161
Brugia malayi CBS domain containing protein 0.0096 0.0101 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0091 0.1687
Schistosoma mansoni cpg binding protein 0.0034 0.0027 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.005 0.0911
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0011 0.0011
Loa Loa (eye worm) phosphatidylinositol 3 0.0088 0.0091 0.0218
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0011 0.0011
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0152 0.0167 0.0167
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0152 0.0167 1
Leishmania major hypothetical protein, conserved 0.0096 0.0101 0.0208
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0037 0.0037
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0013 0.0013
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.3539 0.4176 1
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1521 0.1788 0.4278
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0036 0.0036
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0029 0.0022 0.0036
Leishmania major hypothetical protein, conserved 0.0223 0.0251 0.0568
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0036 0.0085
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0034 0.0065
Echinococcus multilocularis microtubule associated protein 2 0.8462 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0029 0.0022 0.0022
Trypanosoma cruzi chloride channel protein, putative 0.0096 0.0101 0.0241
Schistosoma mansoni microtubule-associated protein tau 0.8462 1 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0059 0.0059
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0023 0.0036
Echinococcus multilocularis apoptotic protease activating factor 1 0.0072 0.0073 0.0073
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0034 0.0066
Plasmodium falciparum protein MAM3, putative 0.0096 0.0101 0.023
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0015 0.003
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0028 0.0028
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0011 0.0011
Mycobacterium ulcerans transcriptional regulator 0.0096 0.0101 0.0224
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0031
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0037 0.0087
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0037 0.0177
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0039 0.3388
Brugia malayi hypothetical protein 0.0022 0.0013 0.0027
Echinococcus granulosus lysine specific demethylase 5A 0.0131 0.0143 0.0143
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.01 0.01
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0059 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.01 0.01
Loa Loa (eye worm) acetyltransferase 0.014 0.0154 0.0367
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Echinococcus granulosus GPCR family 2 0.0033 0.0026 0.0026
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.0143 0.0341
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.0016
Brugia malayi Nuclear hormone receptor E75 0.002 0.0011 0.002
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.3539 0.4176 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0011 0.0011
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0023 0.0053
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0152 0.0167 0.0366
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0034 0.0065
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0013 0.0027
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.1617 0.1901 0.4534
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0059 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0037 0.0082
Brugia malayi chloride channel protein 7 0.0096 0.0101 0.0237
Mycobacterium ulcerans hypothetical protein 0.0096 0.0101 0.0224
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0037 0.0037
Brugia malayi hypothetical protein 0.0072 0.0073 0.017
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.3539 0.4176 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0035 0.0028 0.0051
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.01 0.0235
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0096 0.0101 0.0226
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0192 0.0215 0.0513
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0087
Leishmania major CBS domain protein, conserved 0.0096 0.0101 0.0208
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0072 0.0137
Schistosoma mansoni ap endonuclease 0.004 0.0034 0.0034
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0046 0.0108
Loa Loa (eye worm) hypothetical protein 0.0096 0.0101 0.0241
Schistosoma mansoni cellular tumor antigen P53 0.0192 0.0215 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0043 0.0799
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0096 0.0101 0.0227
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0028 0.0067
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0129 0.0141 0.0141
Brugia malayi CHE-14 protein 0.0041 0.0036 0.0081
Echinococcus multilocularis muscleblind protein 1 0.0175 0.0195 0.0195
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0037 0.0177
Brugia malayi hypothetical protein 0.002 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.01 0.01
Schistosoma mansoni caspase-7 (C14 family) 0.0072 0.0073 0.0073
Mycobacterium tuberculosis Conserved protein 0.0096 0.0101 0.0227
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0058 0.0058
Leishmania major hypothetical protein, conserved 0.0035 0.0028 0.0033
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0003 0.0003
Brugia malayi nuclear receptor NHR-88 0.0041 0.0037 0.0082
Echinococcus multilocularis tumor protein p63 0.1311 0.1538 0.1538
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0007 0.0012
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0088 0.0091 0.0091
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0034 0.0629
Loa Loa (eye worm) hypothetical protein 0.0152 0.0167 0.0399
Trypanosoma brucei GMP reductase 0.3539 0.4176 1
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0096 0.0101 0.0226
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0072 0.0156
Loa Loa (eye worm) hypothetical protein 0.0175 0.0195 0.0465
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0059 0.0135
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0015 0.0812
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0022 0.0406
Brugia malayi hypothetical protein 0.0022 0.0013 0.0027
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0149 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0044 0.08
Onchocerca volvulus 0.0223 0.0251 0.138
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0096 0.0101 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0057 0.1052
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0029 0.0022 0.0018
Echinococcus granulosus H:Cl exchange transporter 7 0.0096 0.0101 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0065 0.1193
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0096 0.0101 0.0208
Loa Loa (eye worm) loechrig isoform VII 0.0096 0.0101 0.0241
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0096 0.0101 0.0161
Leishmania major inosine-5-monophosphate dehydrogenase 0.3539 0.4176 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0004 0.0009
Schistosoma mansoni cpg binding protein 0.0036 0.003 0.003
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0037 0.0037
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0018 0.0009 0.0005
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0015 0.0016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0026 0.0062
Loa Loa (eye worm) hypothetical protein 0.0071 0.0071 0.0169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0065 0.1193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0022 0.0406
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0099 0.0105 0.0236
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Onchocerca volvulus 0.0096 0.0101 0.0539
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0044 0.08
Onchocerca volvulus 0.0041 0.0037 0.0177
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0409 0.0472 0.1129
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0011 0.0011
Trichomonas vaginalis esterase, putative 0.0223 0.0251 0.4656
Brugia malayi ancient conserved domain protein 2 0.0096 0.0101 0.0237
Loa Loa (eye worm) hypothetical protein 0.005 0.0047 0.0111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.01 0.01
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0022 0.0406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0022 0.0406
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0039 0.0074
Brugia malayi beta-lactamase family protein 0.0223 0.0251 0.0596
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0029 0.0022 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0071 0.0071
Schistosoma mansoni hypothetical protein 0.0072 0.0073 0.0073
Loa Loa (eye worm) IMP dehydrogenase 1 0.3539 0.4176 1
Toxoplasma gondii hypothetical protein 0.0056 0.0054 0.0113
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0017 0.0007 0.0016
Plasmodium falciparum JmjC domain-containing protein, putative 0.0035 0.0028 0.0051
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0037 0.0681
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.0143 0.0143
Schistosoma mansoni intermediate filament proteins 0.0026 0.0019 0.0019
Loa Loa (eye worm) GMP reductase 0.1521 0.1788 0.4281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0065 0.1193
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0067
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0087
Echinococcus multilocularis lamin dm0 0.0026 0.0019 0.0019
Trypanosoma cruzi chloride channel protein, putative 0.0096 0.0101 0.0241
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0026
Echinococcus multilocularis GPCR, family 2 0.0033 0.0026 0.0026
Loa Loa (eye worm) inositol-1 0.0043 0.0039 0.0092
Onchocerca volvulus 0.0059 0.0058 0.0295
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0026 0.0057
Onchocerca volvulus 0.0072 0.0073 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.005 0.0911
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0026 0.0026
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0023 0.0037
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.007 0.007 0.0133
Brugia malayi tailless protein 0.002 0.0011 0.002
Brugia malayi ecdysteroid receptor 0.0041 0.0037 0.0082
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0037 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.007 0.1293
Schistosoma mansoni patched 1 0.0041 0.0036 0.0036
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0036 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0037 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0058 0.0058
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0037 0.0037
Onchocerca volvulus 0.0023 0.0015 0.0054
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0002 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0049 0.1131
Mycobacterium tuberculosis Probable lipase LipD 0.0223 0.0251 0.0586
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0035 0.0028 0.0067
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0053
Echinococcus granulosus peptidase Clp S14 family 0.0099 0.0105 0.0105
Brugia malayi jmjC domain containing protein 0.0035 0.0028 0.0063
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0096 0.0101 0.0101
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0026 0.0026
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0096 0.0101 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0015 0.0812
Leishmania major phosphatidylinositol 3-kinase, putative 0.0029 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0031
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.3539 0.4176 1
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0028 0.0028
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0071 0.0071
Schistosoma mansoni zinc finger protein 0.002 0.0011 0.0011
Echinococcus multilocularis serine protein kinase ATM 0.0017 0.0007 0.0007
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0011 0.002
Toxoplasma gondii CBS domain-containing protein 0.0096 0.0101 0.0226
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0096 0.0101 0.0226
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0011 0.0011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Brugia malayi jmjC domain containing protein 0.0035 0.0028 0.0063
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0088 0.0091 0.0218
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0026 0.0026
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0013 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0065 0.1193
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0037 0.0037
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0036 0.0031 0.0056
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0149 0.0149
Echinococcus granulosus apoptotic protease activating factor 1 0.0072 0.0073 0.0073
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0096 0.0101 0.0101
Onchocerca volvulus 0.0026 0.0019 0.0076
Trypanosoma cruzi chloride channel protein, putative 0.0096 0.0101 0.0241
Echinococcus granulosus phd:f box containing protein 0.0035 0.0028 0.0028
Echinococcus multilocularis musashi 0.0026 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0031
Schistosoma mansoni lamin 0.0026 0.0019 0.0019
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0058 0.0058
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0037 0.0082
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0072 0.0072
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0027 0.0064
Trichomonas vaginalis set domain proteins, putative 0.0466 0.0539 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1922 0.2262 0.5409
Loa Loa (eye worm) hypothetical protein 0.0223 0.0251 0.06
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0015 0.0812
Toxoplasma gondii ABC1 family protein 0.0223 0.0251 0.0585
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0039 0.0712
Toxoplasma gondii IMP dehydrogenas 0.3539 0.4176 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0036 0.0668
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0087
Onchocerca volvulus 0.002 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0103 0.011 0.0262
Brugia malayi nuclear receptor RXR 0.0022 0.0013 0.0027
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0152 0.0167 0.0167
Echinococcus multilocularis cpg binding protein 0.0036 0.003 0.003
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0037 0.0082
Onchocerca volvulus 0.0466 0.0539 0.2994
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0037 0.0037
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0088 0.0091 0.0202
Echinococcus multilocularis beta LACTamase domain containing family member 0.0223 0.0251 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0065 0.1193
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0037 0.0037
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0002 0.0002
Schistosoma mansoni chloride channel protein 0.0096 0.0101 0.0101
Brugia malayi FAT domain containing protein 0.0013 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0026
Brugia malayi ecdysone receptor 0.002 0.0011 0.002
Leishmania major hypothetical protein, conserved 0.003 0.0023 0.0019
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0059 0.0058 0.0137
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0018
Mycobacterium ulcerans hypothetical protein 0.0184 0.0205 0.0473
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0011 0.0011
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0037 0.0082
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0037 0.0177
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0036 0.007
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0072 0.0072
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0033 0.0064
Treponema pallidum Mg2+ transport protein (mgtE) 0.0096 0.0101 0.5044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0037 0.0082
Loa Loa (eye worm) hypothetical protein 0.0042 0.0037 0.0088
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0049 0.0046 0.0108
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0096 0.0101 0.0101
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0088 0.0091 0.0202
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.007 0.1293
Schistosoma mansoni jumonji domain containing protein 0.0129 0.0141 0.0141
Mycobacterium leprae conserved hypothetical protein 0.0096 0.0101 0.0208
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.0031 0.0031
Echinococcus multilocularis peptidase Clp (S14 family) 0.0099 0.0105 0.0105
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0007 0.0016
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Brugia malayi ancient conserved domain protein 4 0.0096 0.0101 0.0237
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.0167 0.0382
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0037 0.0082
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0011 0.0011
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.007 0.0071 0.6813
Plasmodium vivax SET domain protein, putative 0.0059 0.0058 0.0123
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.3443 0.4062 1
Entamoeba histolytica hypothetical protein 0.007 0.0071 0.6813
Leishmania major chloride channel protein, putative 0.0096 0.0101 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.01 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0088 0.0091 0.1687
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.0167 0.0383
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0036 0.0668
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.3539 0.4176 1
Mycobacterium leprae Probable lipase LipE 0.0223 0.0251 0.0568
Loa Loa (eye worm) hypothetical protein 0.0175 0.0195 0.0465
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0044
Echinococcus granulosus dnaJ subfamily B 0.048 0.0555 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0009 0.0166
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0026
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0052 0.0049 0.0102
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0059 0.0105
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0049 0.09
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0033 0.0026 0.0026
Mycobacterium leprae conserved hypothetical protein 0.0223 0.0251 0.0568
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0011 0.0011
Brugia malayi CXXC zinc finger family protein 0.0034 0.0027 0.006
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0039 0.0712
Brugia malayi conserved hypotetical protein 0.002 0.0011 0.002
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.0031 0.0031
Echinococcus multilocularis protein dispatched 1 0.0047 0.0043 0.0043
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0154 0.0363
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0034 0.0064
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0034 0.0065
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0023 0.0036
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1423 0.1672 0.3994
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0037 0.0037
Echinococcus multilocularis lamin 0.0026 0.0019 0.0019
Toxoplasma gondii target of rapamycin (TOR), putative 0.0065 0.0065 0.0138
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.011 0.0257
Echinococcus granulosus lamin dm0 0.0026 0.0019 0.0019
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0028 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.006 0.0058 0.0139
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0032 0.2699
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0029 0.0022 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0036 0.066
Brugia malayi Pre-SET motif family protein 0.0059 0.0058 0.0133
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0034
Giardia lamblia GTOR 0.0088 0.0091 0.8558
Schistosoma mansoni thyroid hormone receptor 0.0411 0.0474 0.0474
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0072 0.0153
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0037 0.0037
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.01 1
Echinococcus multilocularis protein patched 0.0041 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0034
Onchocerca volvulus 0.002 0.0011 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0184 0.0205 0.0476
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0096 0.0101 0.5869
Brugia malayi nuclear receptor NHR-67 0.002 0.0011 0.002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0013 0.0013
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0037 0.0037
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.01 0.0237
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0052 0.0049 0.0083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0037 0.0037
Echinococcus granulosus expressed conserved protein 0.009 0.0094 0.0094
Schistosoma mansoni fkbp-rapamycin associated protein 0.0017 0.0007 0.0007
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.007 0.0071 0.6813
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0088 0.0091 0.0184
Loa Loa (eye worm) hypothetical protein 0.0223 0.0251 0.06
Brugia malayi CLC chloride channel protein 0.0096 0.0101 0.0237
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0223 0.0251 0.0586
Trypanosoma cruzi chloride channel protein, putative 0.0096 0.0101 0.0241
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0042
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0096 0.0101 0.0227
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0049 0.0116
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0041 0.0037 0.0071
Echinococcus granulosus caspase 2 0.0072 0.0073 0.0073
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0183 0.0404
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0028 0.0028
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1521 0.1788 0.4278
Mycobacterium ulcerans hypothetical protein 0.0096 0.0101 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.007 0.1293
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0037 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.01 0.0233
Schistosoma mansoni hypothetical protein 0.0039 0.0034 0.0034
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0013 0.0013
Brugia malayi hypothetical protein 0.003 0.0023 0.0049
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0369 0.0424 0.0424
Brugia malayi jmjC domain containing protein 0.0035 0.0028 0.0063
Echinococcus multilocularis neuropeptide s receptor 0.0544 0.0632 0.0632
Chlamydia trachomatis Mg++ transporter 0.0096 0.0101 0.5869
Onchocerca volvulus 0.0223 0.0251 0.138
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0018
Mycobacterium tuberculosis Probable esterase LipL 0.0223 0.0251 0.0586
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0011 0.0011
Echinococcus granulosus H:Cl exchange transporter 4 0.0096 0.0101 0.0101
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0088 0.0091 0.9015
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0011 0.0031
Loa Loa (eye worm) DR-78 0.002 0.0011 0.0025
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0052 0.0049 0.0102
Mycobacterium ulcerans cystathionine beta-synthase 0.0096 0.0101 0.0224
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0059 0.0122
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0036 0.007
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0023 0.0053
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0036 0.0036
Echinococcus granulosus neuropeptide receptor A26 0.0544 0.0632 0.0632
Echinococcus multilocularis muscleblind protein 0.0175 0.0195 0.0195
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0011 0.0031
Chlamydia trachomatis CBS domain-containing protein 0.0096 0.0101 0.5869
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0039 0.0712
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0034 0.0081
Onchocerca volvulus Cell death protein 3 homolog 0.0072 0.0073 0.0382
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0037 0.0082
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0096 0.0101 0.0101
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0037 0.0037
Schistosoma mansoni nuclear receptor 0.002 0.0011 0.0011
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0026 0.0057
Schistosoma mansoni hypothetical protein 0.0369 0.0424 0.0424
Schistosoma mansoni coup transcription factor 0.0041 0.0037 0.0037
Echinococcus granulosus beta LACTamase domain containing family member 0.0223 0.0251 0.0251
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0223 0.0251 0.0586
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0023 0.0037
Mycobacterium tuberculosis Conserved protein 0.0223 0.0251 0.0586
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0026 0.0062
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0039 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0022 0.0406
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0019 0.0044
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0013 0.0013
Loa Loa (eye worm) chloride channel 3 0.0096 0.0101 0.0241
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0072 0.0073 0.0174
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0037 0.0088
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0028 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0007 0.0124
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0152 0.0167 0.032
Brugia malayi jmjC domain containing protein 0.0131 0.0143 0.0337
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0037 0.0037
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0039 0.0092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0004
Toxoplasma gondii CBS domain-containing protein 0.0096 0.0101 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0076 0.1405
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0037 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0037 0.0082
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0096 0.0101 0.0101
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.0143 0.0143
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0029 0.0022 0.0052
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0037 0.0088
Brugia malayi nuclear hormone receptor 0.0041 0.0037 0.0082
Trypanosoma brucei target of rapamycin kinase 3, putative 0.007 0.007 0.0151
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0096 0.0101 0.0101
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.0401 0.0958
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0087
Schistosoma mansoni hypothetical protein 0.0039 0.0034 0.0034
Schistosoma mansoni cpg binding protein 0.0036 0.003 0.003
Mycobacterium ulcerans beta-lactamase 0.0223 0.0251 0.0584
Brugia malayi Inositol-1 0.0043 0.0039 0.0088
Mycobacterium ulcerans hypothetical protein 0.0023 0.0015 0.0016
Mycobacterium tuberculosis Probable lipase LipE 0.0223 0.0251 0.0586
Trypanosoma cruzi GMP reductase 0.3539 0.4176 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0223 0.0251 0.0584
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0096 0.0101 0.0227
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0017 0.0007 0.0007
Schistosoma mansoni thyroid hormone receptor 0.0411 0.0474 0.0474
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0034 0.0629
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.0167 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0034 0.0081
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0011 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0037 0.0082
Brugia malayi Nuclear hormone receptor E75 0.002 0.0011 0.002
Schistosoma mansoni nuclear hormone receptor 0.002 0.0011 0.0011
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0039 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0223 0.0251 0.4656
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0029 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0016
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.007 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0015 0.0277
Trichomonas vaginalis D-aminoacylase, putative 0.0223 0.0251 0.4656
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0096 0.0101 0.0161
Brugia malayi Voltage gated chloride channel family protein 0.0096 0.0101 0.0237
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0013 0.0003 0.0003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0072 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0044 0.08
Onchocerca volvulus 0.0223 0.0251 0.138
Brugia malayi Probable ClpP-like protease 0.0152 0.0167 0.0395
Leishmania major guanosine monophosphate reductase 0.3539 0.4176 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0005
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0034 0.0034
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0096 0.0101 0.0227
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.011 0.0262
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0034 0.0047
Schistosoma mansoni chloride channel protein 0.0096 0.0101 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.0251 0.06
Mycobacterium ulcerans esterase/lipase LipP 0.0223 0.0251 0.0584
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0088 0.0091 0.0091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0037 0.0037
Echinococcus multilocularis thyroid hormone receptor alpha 0.0411 0.0474 0.0474
Mycobacterium tuberculosis Conserved protein 0.0223 0.0251 0.0586
Loa Loa (eye worm) hypothetical protein 0.0223 0.0251 0.06
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0096 0.0101 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0037 0.0037
Brugia malayi Cell death protein 3 precursor 0.0072 0.0073 0.017
Echinococcus granulosus tumor protein p63 0.1311 0.1538 0.1538
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0037 0.0054
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.3539 0.4176 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0037 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0034 0.0034
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0129 0.0141 0.0141
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.0251 0.06
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0029 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.002
Schistosoma mansoni hypothetical protein 0.0039 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0042
Schistosoma mansoni ap endonuclease 0.004 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0096 0.0101 0.0241
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0008 0.0003
Brugia malayi loechrig isoform VII 0.0096 0.0101 0.0237
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.3443 0.4062 1
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0034 0.0077
Loa Loa (eye worm) hypothetical protein 0.0095 0.01 0.024
Loa Loa (eye worm) phosphatidylinositol 3 0.0029 0.0022 0.0052
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0349 0.0401 0.0944
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0028 0.0028
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0049 0.0046 0.0092
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0032 0.006
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0096 0.0101 0.0227
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.3539 0.4176 0.4176
Echinococcus granulosus cpg binding protein 0.0036 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0037 0.0082
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0152 0.0167 1
Loa Loa (eye worm) beta-lactamase 0.0223 0.0251 0.06
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.007 0.1293
Loa Loa (eye worm) hypothetical protein 0.0072 0.0073 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0223 0.0251 0.4656
Trypanosoma brucei hypothetical protein, conserved 0.0223 0.0251 0.0585
Loa Loa (eye worm) hypothetical protein 0.0096 0.0101 0.0241
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0067
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0015 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0011 0.0011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0072 0.0153
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0015 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0009 0.0021
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0149 0.0149
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0096 0.0101 0.0226
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0087
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0096 0.0101 0.0101
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0002 0.0002
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.3539 0.4176 1
Giardia lamblia Hypothetical protein 0.0096 0.0101 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0065 0.1193
Onchocerca volvulus 0.0034 0.0027 0.0125
Leishmania major mitochondrial DNA polymerase beta 0.0349 0.0401 0.0927
Plasmodium vivax hypothetical protein, conserved 0.0223 0.0251 0.06
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0037 0.0037
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0037 0.0037
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0036 0.0036
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0015 0.0019
Mycobacterium ulcerans hypothetical protein 0.0223 0.0251 0.0584
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0058 0.0058
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0028 0.0028
Plasmodium vivax JmjC domain containing protein 0.0035 0.0028 0.0051
Leishmania major chloride channel protein, putative 0.0096 0.0101 0.0208
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0039 0.0058
Onchocerca volvulus Putative GMP reductase 0.1521 0.1788 1
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0096 0.0101 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0015 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0037 0.0681
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0037 0.0037
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0096 0.0101 0.0101
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1617 0.1901 0.4543
Schistosoma mansoni peptidase Clp (S14 family) 0.0152 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0011 0.002
Schistosoma mansoni inositol monophosphatase 0.0043 0.0039 0.0039
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0152 0.0167 0.0392
Schistosoma mansoni protein kinase subunit gamma 0.0096 0.0101 0.0101
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0099 0.0105 0.0236
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0037 0.0037
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.01 0.01
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0058 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0043 0.0799
Brugia malayi steroid hormone receptor 0.0041 0.0037 0.0082
Onchocerca volvulus 0.0026 0.0019 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0049 0.09
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0011 0.002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0029 0.0022 0.0048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0007 0.0012
Echinococcus granulosus H:Cl exchange transporter 3 0.0096 0.0101 0.0101
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0369 0.0424 0.0424
Mycobacterium tuberculosis Conserved protein 0.0096 0.0101 0.0227
Echinococcus granulosus intermediate filament protein 0.0026 0.0019 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0165 0.0183 0.0437
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0349 0.0401 0.0958
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0072 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0037 0.0082
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0037 0.0037
Brugia malayi intermediate filament protein 0.0026 0.0019 0.004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0223 0.0251 0.0586
Loa Loa (eye worm) hypothetical protein 0.0041 0.0037 0.0087
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0011 0.0025
Trichomonas vaginalis penicillin-binding protein, putative 0.0223 0.0251 0.4656
Brugia malayi hypothetical protein 0.002 0.0011 0.002
Brugia malayi GMP reductase 0.1521 0.1788 0.4278
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0096 0.0101 0.0101
Brugia malayi nuclear receptor RXR 0.002 0.0011 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0037 0.0087
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.3443 0.4062 0.9727
Trypanosoma cruzi GMP reductase 0.3539 0.4176 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0152 0.0167 0.0383
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0096 0.0101 0.0227
Brugia malayi Muscleblind-like protein 0.0175 0.0195 0.0461
Treponema pallidum hemolysin (tlyC) 0.0096 0.0101 0.5044
Echinococcus multilocularis neuropeptide receptor A26 0.0544 0.0632 0.0632
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0015 0.0016
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0091 0.0213
Schistosoma mansoni hypothetical protein 0.007 0.0071 0.0071
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0037 0.0037
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.3539 0.4176 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0037 0.0681
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.01 0.01
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0152 0.0167 0.0382
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0028 0.0028
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.3539 0.4176 0.4176
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0035 0.0028 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0025
Schistosoma mansoni nuclear receptor 0.002 0.0011 0.0011
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0071 0.0071
Mycobacterium ulcerans lipase LipD 0.0223 0.0251 0.0584
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0013 0.0031
Brugia malayi hypothetical protein 0.007 0.0071 0.0164
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0015 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0037 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.007 0.1293
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0096 0.0101 0.0241
Brugia malayi beta-lactamase 0.0223 0.0251 0.0596
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0037 0.0037
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0033 0.0045
Mycobacterium ulcerans hypothetical protein 0.0096 0.0101 0.0224
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.011 0.0257
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0037 0.0087
Trypanosoma cruzi target of rapamycin kinase 3 0.007 0.007 0.0167
Schistosoma mansoni hypothetical protein 0.0013 0.0003 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0037 0.0037
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0088 0.0091 0.0091
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0951 0.1113 0.1113
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0028 0.0028
Schistosoma mansoni lamin 0.0026 0.0019 0.0019
Mycobacterium tuberculosis Conserved protein 0.0223 0.0251 0.0586
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.01 0.01
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0037 0.0087
Echinococcus granulosus serine protein kinase ATM 0.0017 0.0007 0.0007
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0015 0.0016
Schistosoma mansoni chloride channel protein 0.0096 0.0101 0.0101
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0037 0.0082
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0017 0.0007 0.0007
Echinococcus multilocularis caspase 2 0.0072 0.0073 0.0073
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0165 0.0183 0.0422
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.3539 0.4176 0.4176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0058 0.0058
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0223 0.0251 0.06
Echinococcus granulosus muscleblind protein 0.0175 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0018
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0035 0.0028 0.0051
Schistosoma mansoni inositol monophosphatase 0.0043 0.0039 0.0039
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0036 0.0036
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0036 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0037 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0007 0.0124
Loa Loa (eye worm) chloride channel protein 7 0.0096 0.0101 0.0241
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0037 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0072 0.0153
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0039 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.005 0.0911
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0037 0.0087
Echinococcus multilocularis lysine specific demethylase 5A 0.0129 0.0141 0.0141
Brugia malayi nuclear hormone receptor 0.002 0.0011 0.002
Schistosoma mansoni hypothetical protein 0.0057 0.0055 0.0055
Echinococcus multilocularis expressed conserved protein 0.009 0.0094 0.0094
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.1922 0.2262 0.5401
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0011 0.0025
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0037 0.0697
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0049 0.0046 0.0108
Brugia malayi Pre-SET motif family protein 0.0409 0.0472 0.1126
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0026 0.0026
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0223 0.0251 0.0596
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0037 0.0037
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0096 0.0101 0.0101
Brugia malayi hypothetical protein 0.0019 0.001 0.0019
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0028 0.0028
Brugia malayi jmjC domain containing protein 0.0129 0.0141 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0044 0.08
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0023 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0031
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0011 0.0011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0039 0.0092
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0034 0.2913
Entamoeba histolytica hypothetical protein 0.007 0.0071 0.6813
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0034 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0007 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.01 0.01
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0037 0.3213
Loa Loa (eye worm) hypothetical protein 0.0223 0.0251 0.06
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0018
Toxoplasma gondii hypothetical protein 0.0052 0.0049 0.0101
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0015 0.0016
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.3539 0.4176 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0059 0.0059
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0019 0.0044
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0004 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0034 0.0081
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0071 0.0165
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0028 0.0067
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0096 0.0101 0.0101
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0088 0.0091 0.0184
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0043 0.0799
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0072 0.0155
Onchocerca volvulus 0.0192 0.0215 0.1175
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0037 0.0084
Brugia malayi beta-lactamase family protein 0.0223 0.0251 0.0596
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0037 0.0037
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0096 0.0101 0.0241
Loa Loa (eye worm) hypothetical protein 0.0023 0.0015 0.0034
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0154 0.0154
Echinococcus multilocularis dnaJ subfamily B 0.048 0.0555 0.0555
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0065 0.1193
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0037 0.0082
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0096 0.0101 1
Schistosoma mansoni hypothetical protein 0.0039 0.0034 0.0034
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0019 0.004

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 141.2538 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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