TDR Targets

Basic information

Technical information

TDR Targets ID: 1470157
Name: 1-[(4-fluorophenyl)methyl]indole-3-carbaldehy de
MW: 253.271 | Formula: C16H12FNO
H donors: 0 H acceptors: 1 LogP: 3.16 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=Cc1cn(c2c1cccc2)Cc1ccc(cc1)F
InChi: 1S/C16H12FNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10-11H,9H2
InChiKey: NZBLQHFUUZBVFC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[(4-fluorophenyl)methyl]-3-indolecarboxaldehyde
1-(4-fluorobenzyl)indole-3-carbaldehyde
ZINC00336018
SBB009344
AN-648/13413003
MLS000709271
SMR000289938
1-(4-Fluoro-benzyl)-1H-indole-3-carbaldehyde
BAS 01856335

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Starlite/ChEMBL	No references
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase		No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Trypanosoma brucei gambiense	ATP-dependent phosphofructokinase,6-phospho-1-fructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma congolense	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	hypothetical protein	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania mexicana	6-phospho-1-fructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma japonicum	ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania donovani	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C)	Get druggable targets OG5_126758	All targets in OG5_126758
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania major	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus granulosus	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania infantum	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	6 phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Trichomonas vaginalis	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Leishmania braziliensis	ATP-dependent phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Loa Loa (eye worm)	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	Get druggable targets OG5_126758	All targets in OG5_126758
Schistosoma mansoni	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	6-phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Entamoeba histolytica	phosphofructokinase, putative	Get druggable targets OG5_126758	All targets in OG5_126758
Brugia malayi	phosphofructokinase	Get druggable targets OG5_126758	All targets in OG5_126758
Candida albicans	phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C)	Get druggable targets OG5_126758	All targets in OG5_126758
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	pyruvate kinase	0.0017	0.0079	0.0159
Schistosoma mansoni	nAChR subunit	0.0018	0.0097	0.0195
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0109	0.0109
Echinococcus multilocularis	ubiquitin specific protease 41	0.0039	0.0347	0.0347
Echinococcus granulosus	pyruvate kinase	0.0032	0.0263	0.0511
Brugia malayi	DNA topoisomerase III	0.0022	0.0147	0.0355
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0001	0.0001
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0112	0.1195	0.1775
Plasmodium falciparum	DNA topoisomerase 3, putative	0.0022	0.0147	0.0209
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0022	0.0147	0.0279
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0568	0.6524	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0097	0.0236
Echinococcus multilocularis	glycine receptor subunit beta	0.0018	0.0097	0.0097
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0015	0.0063	0.0037
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0263	0.0635
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0676	0.1635
Schistosoma mansoni	nAChR subunit	0.0018	0.0097	0.0195
Schistosoma mansoni	heat shock protein	0.0014	0.0045	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1083	0.2618
Brugia malayi	hypothetical protein	0.0043	0.0394	0.0952
Schistosoma mansoni	nAChR subunit	0.0018	0.0097	0.0195
Entamoeba histolytica	hypothetical protein	0.0043	0.0394	0.0538
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.142	0.2122
Brugia malayi	MH2 domain containing protein	0.001	0.0001	0.0002
Brugia malayi	jmjC domain containing protein	0.0015	0.0063	0.0153
Loa Loa (eye worm)	Smad1	0.001	0.0001	0.0002
Echinococcus granulosus	dnaJ subfamily B	0.0436	0.4988	0.9712
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0035	0.03	0.0394
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0231	0.0231
Schistosoma mansoni	pyruvate dehydrogenase	0.0014	0.0045	0.0091
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0363	0.4134	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0022	0.0142	0.0343
Onchocerca volvulus		0.0018	0.0097	0.0236
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0231	0.0384
Loa Loa (eye worm)	DNA topoisomerase III beta-1	0.0022	0.0147	0.0355
Plasmodium vivax	6-phosphofructokinase, putative	0.0035	0.03	0.0526
Onchocerca volvulus		0.0058	0.0567	0.1371
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0676	0.1355
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0018	0.0097	0.0236
Brugia malayi	RNA binding protein	0.0068	0.0676	0.1635
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.03	0.0394
Brugia malayi	follicle stimulating hormone receptor	0.0226	0.2533	0.6127
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0009	0.0018
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0018	0.0097	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1083	0.2618
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0257	0.2886	0.7819
Schistosoma mansoni	nAChR subunit	0.0018	0.0097	0.0195
Mycobacterium tuberculosis	DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0428	0.4895	1
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.0035	0.03	0.0394
Echinococcus multilocularis	cpg binding protein	0.0032	0.0264	0.0264
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0018	0.0097	0.0097
Schistosoma mansoni	nAChR subunit	0.0018	0.0097	0.0195
Entamoeba histolytica	DNA topoisomerase II, putative	0.0279	0.3147	0.4787
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0743	0.0743
Trichomonas vaginalis	pyruvate kinase, putative	0.0032	0.0263	0.0335
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0743	0.1921
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0063	0.0153
Schistosoma mansoni	nAChR subunit	0.0018	0.0097	0.0195
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.3224	0.6278
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0231	0.0231
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0018	0.0097	0.0236
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0743	0.1439
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0035	0.03	0.0526
Schistosoma mansoni	pyruvate kinase	0.0032	0.0263	0.0526
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.0022	0.0147	0.0209
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0257	0.2886	0.7819
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0368	0.0498
Echinococcus granulosus	6 phosphofructokinase	0.0131	0.142	0.2766
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0039	0.0347	0.0831
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1571	0.38
Echinococcus multilocularis	Smad4	0.001	0.0001	0.0001
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0363	0.4134	0.8432
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.142	0.2848
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.142	0.3435
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0018	0.0097	0.0097
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0363	0.4134	0.6311
Schistosoma mansoni	DNA topoisomerase II	0.0279	0.3147	0.6309
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0098	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0263	0.0635
Trichomonas vaginalis	set domain proteins, putative	0.023	0.2574	0.3902
Plasmodium vivax	DNA topoisomerase II, putative	0.0279	0.3147	0.6396
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0195	0.0473
Toxoplasma gondii	exonuclease III APE	0.0018	0.0098	0.0109
Schistosoma mansoni	endoplasmin	0.0014	0.0045	0.0091
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.03	0.0394
Mycobacterium ulcerans	pyruvate kinase	0.0032	0.0263	0.0448
Trypanosoma brucei	pyruvate kinase 1, putative	0.0032	0.0263	0.0598
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0347	0.0347
Trypanosoma brucei	pyruvate kinase 1	0.0032	0.0263	0.0598
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0098	0.0146
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0222	0.2479	0.5019
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0018	0.0097	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0263	0.0263
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0001	0.0001
Entamoeba histolytica	pyruvate kinase, putative	0.0022	0.0149	0.0159
Toxoplasma gondii	pyruvate kinase PyKII	0.0017	0.0079	0.007
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0001	0.0001
Onchocerca volvulus	Putative nachr subunit	0.0018	0.0097	0.0236
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.03	0.0394
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0097	0.0236
Chlamydia trachomatis	DNA topoisomerase I	0.0022	0.0147	0.0209
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0098	0.0109
Echinococcus multilocularis	lamin dm0	0.0055	0.0527	0.0527
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0676	0.1635
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0098	0.0238
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0328	0.0583
Echinococcus multilocularis	pyruvate kinase	0.0025	0.0183	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0527	0.1275
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0098	0.0109
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0035	0.03	0.0526
Schistosoma mansoni	endoplasmin	0.0014	0.0045	0.0091
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0022	0.0147	0.0279
Schistosoma mansoni	hypothetical protein	0.0058	0.0567	0.1136
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.142	0.2122
Giardia lamblia	Pyruvate kinase	0.0032	0.0263	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Echinococcus granulosus	smad	0.001	0.0001	0.0001
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.0022	0.0147	0.0279
Brugia malayi	MH1 domain containing protein	0.001	0.0001	0.0002
Echinococcus granulosus	lamin	0.0055	0.0527	0.1027
Brugia malayi	TAR-binding protein	0.0068	0.0676	0.1635
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0676	0.0676
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0098	0.0109
Echinococcus multilocularis	nAChR subunit	0.0018	0.0097	0.0097
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0363	0.4134	0.6311
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0244	0.059
Schistosoma mansoni	smad1 5 8 and	0.001	0.0001	0.0001
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0328	0.0436
Entamoeba histolytica	hypothetical protein	0.0043	0.0394	0.0538
Echinococcus multilocularis	glycine receptor subunit beta	0.0018	0.0097	0.0097
Trypanosoma brucei	DNA topoisomerase III, putative	0.0022	0.0147	0.0279
Schistosoma mansoni	hypothetical protein	0.0166	0.1821	0.3651
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0097	0.0097
Echinococcus granulosus	DNA topoisomerase 3 beta 1	0.0022	0.0147	0.0286
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0231	0.0464
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0018	0.0097	0.0097
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0018	0.0097	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0363	0.4134	0.6311
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.0617	0.1179
Echinococcus multilocularis	smad	0.001	0.0001	0.0001
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0676	0.1355
Echinococcus granulosus	pyruvate kinase	0.0032	0.0263	0.0511
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0097	0.0236
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0014	0.0045	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Leishmania major	DNA topoisomerase III, putative	0.0022	0.0147	0.0279
Onchocerca volvulus		0.0018	0.0097	0.0236
Echinococcus multilocularis	6 phosphofructokinase	0.0131	0.142	0.142
Loa Loa (eye worm)	intermediate filament protein	0.0055	0.0527	0.1275
Schistosoma mansoni	hypothetical protein	0.0166	0.1821	0.3651
Schistosoma mansoni	heat shock protein	0.0014	0.0045	0.0091
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0368	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Schistosoma mansoni	6-phosphofructokinase	0.0131	0.142	0.2848
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0015	0.0063	0.005
Brugia malayi	intermediate filament protein	0.0055	0.0527	0.1275
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0131	0.142	0.2835
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0001	0.0002
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0676	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0367	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3224	0.7798
Echinococcus granulosus	lamin dm0	0.0055	0.0527	0.1027
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.03	0.0394
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0112	0.1195	0.3166
Echinococcus granulosus	glycine receptor subunit beta	0.0018	0.0097	0.019
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0039	0.0347	0.084
Mycobacterium leprae	Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0121	0.1305	0.4087
Toxoplasma gondii	6-phosphofructokinase	0.0035	0.03	0.0526
Plasmodium falciparum	pyruvate kinase 2	0.0017	0.0079	0.007
Loa Loa (eye worm)	acetyltransferase	0.014	0.1526	0.369
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.014	0.1526	0.3059
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0263	0.0635
Onchocerca volvulus		0.003	0.0231	0.056
Schistosoma mansoni	lamin	0.0055	0.0527	0.1057
Plasmodium vivax	DNA topoisomerase 3, putative	0.0022	0.0147	0.0209
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0098	0.0109
Echinococcus granulosus	pyruvate kinase	0.0017	0.0079	0.0154
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0097	0.0236
Leishmania major	hypothetical protein, conserved	0.0112	0.1195	0.3166
Leishmania major	pyruvate kinase	0.0032	0.0263	0.0598
Plasmodium vivax	pyruvate kinase, putative	0.0032	0.0263	0.0448
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0018	0.0097	0.0236
Onchocerca volvulus	Putative DNA topoisomerase 2, mitochondrial	0.0218	0.2434	0.5888
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0063	0.0153
Trypanosoma cruzi	DNA topoisomerase III, putative	0.0022	0.0147	0.0279
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0324	0.3678	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0097	0.0236
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0018	0.0097	0.0236
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0098	0.0082
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0347	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0572	0.1146
Schistosoma mansoni	phosphatidylserine receptor	0.0015	0.0063	0.0127
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0015	0.0063	0.0037
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0018	0.0097	0.019
Schistosoma mansoni	lamin	0.0055	0.0527	0.1057
Loa Loa (eye worm)	hypothetical protein	0.006	0.059	0.1426
Mycobacterium ulcerans	DNA gyrase subunit A	0.0428	0.4895	1
Treponema pallidum	DNA topoisomerase I (topA)	0.0022	0.0147	0.0157
Loa Loa (eye worm)	LGC-31 protein	0.0018	0.0097	0.0236
Chlamydia trachomatis	DNA gyrase subunit B	0.0176	0.1948	0.3923
Leishmania major	DNA topoisomerase III, putative	0.0022	0.0147	0.0279
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.03	0.0394
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0394	0.0394
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0347	0.0676
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0328	0.0436
Brugia malayi	excitatory GABA receptor EXP-1A	0.0018	0.0097	0.0236
Mycobacterium leprae	Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase)	0.0077	0.079	0.2415
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0257	0.2886	0.7819
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0018	0.0097	0.0097
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0018	0.0097	0.0236
Echinococcus multilocularis	phd:f box containing protein	0.0015	0.0063	0.0063
Echinococcus granulosus	geminin	0.0166	0.1821	0.3546
Echinococcus granulosus	lysine specific demethylase 5A	0.0059	0.0572	0.1113
Onchocerca volvulus		0.0055	0.0527	0.1275
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0098	0.0082
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0097	0.0236
Onchocerca volvulus		0.0018	0.0097	0.0236
Giardia lamblia	DNA topoisomerase III	0.0022	0.0147	0.0157
Schistosoma mansoni	hypothetical protein	0.0019	0.0109	0.0218
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0018	0.0097	0.0195
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0017	0.0084	0.0084
Wolbachia endosymbiont of Brugia malayi	DNA gyrase subunit A	0.0428	0.4895	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0184	0.0444
Schistosoma mansoni	smad	0.001	0.0001	0.0001
Schistosoma mansoni	intermediate filament proteins	0.0055	0.0527	0.1057
Schistosoma mansoni	jumonji domain containing protein	0.0057	0.0551	0.1105
Echinococcus granulosus	intermediate filament protein	0.0055	0.0527	0.1027
Echinococcus multilocularis	musashi	0.0055	0.0527	0.0527
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0098	0.0082
Onchocerca volvulus	Pyruvate kinase homolog	0.0032	0.0263	0.0635
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0251	0.2825	0.5731
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0063	0.0153
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0032	0.0263	0.0705
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0059	0.0572	0.1146
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0195	0.0381
Schistosoma mansoni	jumonji domain containing protein	0.0015	0.0063	0.0127
Loa Loa (eye worm)	pyruvate kinase-PB	0.0022	0.0149	0.0359
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0568	0.6524	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0039	0.0347	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0186	0.2062	0.4987
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0045	0.0109
Echinococcus multilocularis	JmjC domain containing protein 4	0.0015	0.0063	0.0063
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0112	0.1195	0.1775
Brugia malayi	Pre-SET motif family protein	0.003	0.0231	0.056
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0018	0.0097	0.0236
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1571	0.38
Mycobacterium ulcerans	6-phosphofructokinase	0.0131	0.142	0.2835
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0279	0.3147	0.7612
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0279	0.3147	0.6396
Echinococcus multilocularis	lamin	0.0055	0.0527	0.0527
Giardia lamblia	DNA topoisomerase III	0.0022	0.0147	0.0157
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0277	0.3129	0.6358
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0676	0.1355
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0018	0.0097	0.0236
Brugia malayi	MH1 domain containing protein	0.001	0.0001	0.0002
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.1195	0.3166
Echinococcus granulosus	JmjC domain containing protein 4	0.0015	0.0063	0.0123
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0018	0.0097	0.019
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0229	0.0555
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0367	0.0888
Echinococcus multilocularis	DNA topoisomerase 3 beta 1	0.0022	0.0147	0.0147
Brugia malayi	Pre-SET motif family protein	0.0202	0.2248	0.5438
Onchocerca volvulus		0.0018	0.0097	0.0236
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0063	0.005
Onchocerca volvulus		0.0018	0.0097	0.0236
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.017	0.1875	0.3773
Echinococcus multilocularis	heat shock protein 90	0.0014	0.0045	0.0045
Loa Loa (eye worm)	ACC-1 protein	0.0018	0.0097	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Echinococcus granulosus	heat shock protein	0.0014	0.0045	0.0088
Brugia malayi	Cation transporter family protein	0.0018	0.0097	0.0236
Schistosoma mansoni	hypothetical protein	0.0043	0.0394	0.0789
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0568	0.6524	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0363	0.4134	0.6311
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0258	0.0625
Plasmodium falciparum	DNA topoisomerase 2	0.0279	0.3147	0.6396
Echinococcus multilocularis	pyruvate kinase	0.0032	0.0263	0.0263
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0363	0.4134	0.6311
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0279	0.3147	0.6128
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0032	0.0263	0.0598
Schistosoma mansoni	cpg binding protein	0.0031	0.0244	0.0489
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0347	0.0466
Leishmania major	DNA topoisomerase ii	0.0257	0.2886	0.7819
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0149	0.0359
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0568	0.6524	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0018	0.0097	0.019
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0743	0.1439
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0079	0.0079
Schistosoma mansoni	ap endonuclease	0.0018	0.0098	0.0197
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0097	0.0195
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0018	0.0097	0.0236
Wolbachia endosymbiont of Brugia malayi	topoisomerase IA, TopA	0.0022	0.0147	0.0209
Schistosoma mansoni	ap endonuclease	0.0018	0.0098	0.0197
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0109	0.0211
Echinococcus granulosus	nAChR subunit	0.0018	0.0097	0.019
Echinococcus multilocularis	geminin	0.0166	0.1821	0.1821
Entamoeba histolytica	hypothetical protein	0.0043	0.0394	0.0538
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0098	0.0146
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0097	0.019
Giardia lamblia	Fructose-bisphosphate aldolase	0.0568	0.6524	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0039	0.0347	0.0696
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0568	0.6524	1
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0008	0.0019
Loa Loa (eye worm)	phosphofructokinase	0.0131	0.142	0.3435
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0097	0.0236
Mycobacterium leprae	Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) (	0.0022	0.0147	0.0329
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.142	0.2122
Trypanosoma brucei	DNA topoisomerase III, putative	0.0022	0.0147	0.0279
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0279	0.3147	0.4787
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0098	0.0098
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0018	0.0097	0.0236
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0363	0.4134	0.6311
Echinococcus granulosus	glycine receptor subunit beta	0.0018	0.0097	0.019
Plasmodium vivax	DNA gyrase subunit A, putative	0.0428	0.4895	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0059	0.0572	0.1383
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0001	0.0001
Chlamydia trachomatis	DNA gyrase subunit A	0.0428	0.4895	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.142	0.2122
Schistosoma mansoni	cpg binding protein	0.0032	0.0264	0.053
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0257	0.2886	0.7819
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0018	0.0097	0.019
Trichomonas vaginalis	pyruvate kinase, putative	0.0032	0.0263	0.0335
Brugia malayi	MH2 domain containing protein	0.0144	0.1571	0.38
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0022	0.0147	0.0294
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0018	0.0097	0.019
Loa Loa (eye worm)	TOPoisomerase family member	0.0279	0.3147	0.7612
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0109	0.0109
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0001	0.0001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0231	0.0464
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0097	0.0236
Leishmania major	hypothetical protein, conserved	0.0015	0.0063	0.005
Trypanosoma cruzi	DNA topoisomerase IA, putative	0.0022	0.0147	0.0279
Brugia malayi	GRF zinc finger family protein	0.0022	0.0147	0.0355
Echinococcus multilocularis	neuropeptide s receptor	0.0449	0.5135	0.5135
Echinococcus granulosus	phd:f box containing protein	0.0015	0.0063	0.0123
Echinococcus granulosus	pyruvate kinase	0.0017	0.0079	0.0154
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0394	0.0767
Brugia malayi	Cation transporter family protein	0.0018	0.0097	0.0236
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0097	0.0097
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0063	0.0153
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0743	0.1439
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0032	0.0263	0.0448
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0263	0.0635
Plasmodium falciparum	DNA gyrase subunit A	0.0428	0.4895	1
Onchocerca volvulus	Huntingtin homolog	0.0249	0.28	0.6773
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0097	0.019
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0009	0.0009
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0098	0.0082
Onchocerca volvulus		0.0022	0.0147	0.0355
Brugia malayi	Probable DNA topoisomerase II	0.0279	0.3147	0.7612
Echinococcus granulosus	Smad4	0.001	0.0001	0.0001
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0363	0.4134	0.6311
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0035	0.03	0.0526
Schistosoma mansoni	hypothetical protein	0.0019	0.0109	0.0218
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0676	0.1316
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0394	0.0789
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0218	0.2434	0.5888
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Schistosoma mansoni	nAChR subunit	0.0018	0.0097	0.0195
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0743	0.1439
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0039	0.0347	0.0466
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.0022	0.0147	0.0157
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0098	0.0082
Brugia malayi	Intermediate filament tail domain containing protein	0.0055	0.0527	0.1275
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0244	0.059
Onchocerca volvulus	Huntingtin homolog	0.0249	0.28	0.6773
Toxoplasma gondii	DNA gyrase/topoisomerase IV, A subunit domain-containing protein	0.0428	0.4895	1
Mycobacterium ulcerans	DNA gyrase subunit B	0.0222	0.2479	0.5019
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0263	0.0635
Leishmania major	DNA topoisomerase 1A	0.0022	0.0147	0.0279
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0568	0.6524	1
Brugia malayi	hypothetical protein	0.0249	0.28	0.6773
Echinococcus granulosus	DNA topoisomerase 3 alpha	0.0022	0.0147	0.0286
Onchocerca volvulus		0.0031	0.0244	0.059
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0035	0.03	0.0394
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0131	0.142	0.446
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0018	0.0097	0.019
Brugia malayi	jmjC domain containing protein	0.0059	0.0572	0.1383
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0222	0.2479	0.5019
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0743	0.149
Chlamydia trachomatis	DNA gyrase subunit B	0.0222	0.2479	0.5019
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0324	0.3678	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0211	0.0411
Entamoeba histolytica	DNA topoisomerase III, putative	0.0022	0.0147	0.0157
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0055	0.0527	0.1275
Trichomonas vaginalis	phosphofructokinase, putative	0.0131	0.142	0.2122
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0347	0.0831
Echinococcus granulosus	ubiquitin specific protease 41	0.0039	0.0347	0.0676
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0057	0.0551	0.1073
Leishmania major	pyruvate kinase	0.0032	0.0263	0.0598
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0676	0.1635
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0057	0.0551	0.0551
Brugia malayi	heat shock protein 90	0.0014	0.0045	0.0109
Plasmodium falciparum	DNA gyrase subunit B	0.0222	0.2479	0.5019
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.059	0.1426
Chlamydia trachomatis	fructose-6-phosphate phosphotransferase	0.0035	0.03	0.0526
Brugia malayi	MH2 domain containing protein	0.001	0.0001	0.0002
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.014	0.1526	0.1526
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0015	0.0063	0.005
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0231	0.0464
Brugia malayi	phosphofructokinase	0.0131	0.142	0.3435
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.142	0.3785
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0229	0.0555
Plasmodium vivax	6-phosphofructokinase, putative	0.0035	0.03	0.0526
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0568	0.6524	1
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0222	0.2479	0.3757
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0098	0.0238
Echinococcus granulosus	jumonji domain containing 1A	0.0015	0.0063	0.0123
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0018	0.0097	0.019
Loa Loa (eye worm)	ACC-1 protein	0.0018	0.0097	0.0236
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0039	0.0347	0.0696
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0018	0.0097	0.019
Schistosoma mansoni	Smad4	0.001	0.0001	0.0001
Schistosoma mansoni	hypothetical protein	0.0019	0.0109	0.0218
Plasmodium vivax	pyruvate kinase 2, putative	0.0017	0.0079	0.007
Echinococcus granulosus	neuropeptide receptor A26	0.0449	0.5135	1
Chlamydia trachomatis	DNA gyrase subunit A	0.0093	0.0977	0.1921
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0015	0.0063	0.0037
Plasmodium vivax	JmjC domain containing protein	0.0015	0.0063	0.0037
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0277	0.3129	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0743	0.149
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0279	0.3147	0.3147
Loa Loa (eye worm)	histone methyltransferase	0.0011	0.0009	0.0022
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.0658	0.1319
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0063	0.0153
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0098	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Brugia malayi	DNA topoisomerase III beta-1	0.0022	0.0147	0.0355
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.059	0.1426
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0017	0.0084	0.0163
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0109	0.0263
Loa Loa (eye worm)	jmjC domain-containing protein	0.0015	0.0063	0.0153
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0676	0.1635
Echinococcus granulosus	pyruvate kinase	0.0017	0.0079	0.0154
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0231	0.0451
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0014	0.0045	0.0045
Brugia malayi	Cytochrome P450 family protein	0.0022	0.0142	0.0343
Brugia malayi	hypothetical protein	0.0286	0.3224	0.7798
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0018	0.0097	0.0097
Brugia malayi	jmjC domain containing protein	0.0057	0.0551	0.1333
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0098	0.0146
Onchocerca volvulus		0.023	0.2574	0.6225
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0568	0.6524	1
Loa Loa (eye worm)	endoplasmin	0.0014	0.0045	0.0109
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0018	0.0097	0.0236
Plasmodium vivax	SET domain protein, putative	0.003	0.0231	0.0384
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0039	0.0347	0.0676
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0109	0.0263
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0743	0.1447
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0109	0.0263
Treponema pallidum	DNA gyrase, subunit A (gyrA)	0.0428	0.4895	0.7485
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Brugia malayi	Smad1	0.001	0.0001	0.0002
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0035	0.03	0.0394
Leishmania major	ATP-dependent phosphofructokinase	0.0131	0.142	0.3785
Chlamydia trachomatis	pyruvate kinase	0.0032	0.0263	0.0448
Onchocerca volvulus		0.0055	0.0527	0.1275
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0018	0.0097	0.0236
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0039	0.0347	0.0466
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0032	0.0263	0.0635
Schistosoma mansoni	hypothetical protein	0.0041	0.0367	0.0736
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0014	0.0045	0.0045
Brugia malayi	6-phosphofructokinase	0.0131	0.142	0.3435
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0097	0.0195
Echinococcus multilocularis	pyruvate kinase	0.0017	0.0079	0.0079
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0231	0.0464
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0363	0.4134	1
Schistosoma mansoni	phd/f-box containing protein	0.0015	0.0063	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0258	0.0625
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0368	0.0666
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0568	0.6524	1
Echinococcus granulosus	lysine specific demethylase 6a	0.0015	0.0063	0.0123
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0567	0.1136
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0131	0.142	0.3785
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0018	0.0097	0.0195
Mycobacterium ulcerans	DNA topoisomerase I	0.0022	0.0147	0.0209
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0039	0.0347	0.0466
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0676	0.1355
Entamoeba histolytica	hypothetical protein	0.0043	0.0394	0.0538
Trichomonas vaginalis	phosphofructokinase, putative	0.0035	0.03	0.0394
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0277	0.3129	0.6358
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0743	0.1439
Loa Loa (eye worm)	hypothetical protein	0.003	0.0231	0.056
Loa Loa (eye worm)	hypothetical protein	0.0249	0.28	0.6773
Trypanosoma brucei	DNA topoisomerase ii	0.0324	0.3678	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.059	0.1426
Schistosoma mansoni	smad1 5 8 and	0.001	0.0001	0.0001
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0226	0.2533	0.6127
Plasmodium vivax	DNA gyrase subunit B, putative	0.0222	0.2479	0.5019
Echinococcus multilocularis	dnaJ subfamily B	0.0436	0.4988	0.4988
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0568	0.6524	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.2062	0.4987
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0018	0.0097	0.0195
Trypanosoma brucei	DNA topoisomerase IA, putative	0.0022	0.0147	0.0279
Echinococcus granulosus	GPCR family 2	0.0019	0.0109	0.0211
Trypanosoma cruzi	hypothetical protein, conserved	0.0112	0.1195	0.3166
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0363	0.4134	0.6311
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0136	0.148	0.2881
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0258	0.0625
Brugia malayi	Cation transporter family protein	0.0018	0.0097	0.0236
Echinococcus multilocularis	lysine specific demethylase 5A	0.0057	0.0551	0.0551
Onchocerca volvulus		0.0363	0.4134	1
Echinococcus granulosus	cpg binding protein	0.0032	0.0264	0.0515
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0041	0.0368	0.0666
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0039	0.0347	0.0347
Echinococcus granulosus	heat shock protein 90	0.0014	0.0045	0.0088
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0131	0.142	0.2122
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0098	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0249	0.28	0.6773
Treponema pallidum	fructose-bisphosphate aldolase	0.0568	0.6524	1
Entamoeba histolytica	DNA topoisomerase III, putative	0.0022	0.0147	0.0157
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0279	0.3147	0.7612
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0035	0.03	0.0526
Loa Loa (eye worm)	pyruvate kinase	0.0032	0.0263	0.0635
Brugia malayi	jmjC domain containing protein	0.0015	0.0063	0.0153
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0032	0.0263	0.0635
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0097	0.0097
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0039	0.0347	0.0831
Echinococcus granulosus	neuropeptide s receptor	0.0449	0.5135	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0567	0.1371
Toxoplasma gondii	DNA topoisomerase family protein	0.0022	0.0147	0.0209
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0368	0.0498
Onchocerca volvulus		0.0018	0.0097	0.0236
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0018	0.0097	0.0195
Giardia lamblia	Pyruvate kinase	0.0017	0.0079	0.0052
Echinococcus multilocularis	neuropeptide receptor A26	0.0449	0.5135	0.5135
Toxoplasma gondii	phosphofructokinase PFKII	0.0035	0.03	0.0526
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.3224	0.3224
Schistosoma mansoni	hypothetical protein	0.0436	0.4988	1
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.142	0.2122
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Plasmodium falciparum	pyruvate kinase	0.0032	0.0263	0.0448
Toxoplasma gondii	pyruvate kinase PyK1	0.0032	0.0263	0.0448
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0195	0.0195
Schistosoma mansoni	prokaryotic DNA topoisomerase	0.0022	0.0147	0.0294
Loa Loa (eye worm)	DNA topoisomerase III	0.0022	0.0147	0.0355
Brugia malayi	6-phosphofructokinase	0.0131	0.142	0.3435
Brugia malayi	acetyltransferase, GNAT family protein	0.014	0.1526	0.369
Brugia malayi	kinase, mitochondrial precursor	0.0014	0.0045	0.0109
Schistosoma mansoni	smad1 5 8 and	0.001	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0516	0.1247
Schistosoma mansoni	cpg binding protein	0.0032	0.0264	0.053
Schistosoma mansoni	protein phosphatase 2C	0.0015	0.0063	0.0127
Echinococcus multilocularis	lysine specific demethylase 6a	0.0015	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0347	0.084
Brugia malayi	Endoplasmin precursor	0.0014	0.0045	0.0109
Brugia malayi	jmjC domain containing protein	0.0015	0.0063	0.0153
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0015	0.0063	0.0127
Echinococcus multilocularis	heat shock protein	0.0014	0.0045	0.0045
Brugia malayi	jmjC domain containing protein	0.0015	0.0063	0.0153
Trichomonas vaginalis	prokaryotic DNA topoisomerase, putative	0.0022	0.0147	0.0157
Echinococcus multilocularis	rho GTPase activating protein 20	0.0022	0.0147	0.0147
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0109	0.0263
Schistosoma mansoni	pyruvate kinase	0.0032	0.0263	0.0526
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0032	0.0263	0.0598
Schistosoma mansoni	hypothetical protein	0.0019	0.0109	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0001	0.0002
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0018	0.0097	0.0236
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0018	0.0097	0.019
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0041	0.0368	0.0666
Leishmania major	mitochondrial DNA topoisomerase II	0.0324	0.3678	1
Loa Loa (eye worm)	heat shock protein 90	0.0014	0.0045	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0184	0.0444
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0097	0.0236
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0363	0.4134	0.6311
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2248	0.5438
Entamoeba histolytica	phosphofructokinase, putative	0.0131	0.142	0.2122
Onchocerca volvulus	DNA topoisomerase 2 homolog	0.0218	0.2434	0.5888
Loa Loa (eye worm)	6-phosphofructokinase	0.0131	0.142	0.3435
Echinococcus multilocularis	jumonji domain containing 1A	0.0015	0.0063	0.0063
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0018	0.0097	0.0097
Giardia lamblia	DNA topoisomerase II	0.0265	0.2987	0.4541
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0109	0.0109
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0109	0.0211

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.1 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 0.1259 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 0.3548 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.7079 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	0.8275 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.9955 uM	PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	25.929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	= 89.1251 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	125.8925 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1586862

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1470157