Detailed information for compound 1471646

Basic information

Technical information
  • TDR Targets ID: 1471646
  • Name: N-[2-[2-(2-bromo-4-chlorophenoxy)ethoxy]ethyl ]butan-2-amine
  • MW: 350.679 | Formula: C14H21BrClNO2
  • H donors: 1 H acceptors: 0 LogP: 3.96 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(NCCOCCOc1ccc(cc1Br)Cl)C
  • InChi: 1S/C14H21BrClNO2/c1-3-11(2)17-6-7-18-8-9-19-14-5-4-12(16)10-13(14)15/h4-5,10-11,17H,3,6-9H2,1-2H3
  • InChiKey: FHEMKPMORHQQQS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[2-(2-bromo-4-chloro-phenoxy)ethoxy]ethyl]butan-2-amine
  • 2-[2-(2-bromo-4-chloro-phenoxy)ethoxy]ethyl-sec-butyl-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0057 0.039 0.0867
Schistosoma mansoni nuclear receptor nhr-48 0.0129 0.1756 0.2553
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0144 0.205 0.2981
Echinococcus multilocularis insulin receptor 0.0052 0.0289 0.0419
Loa Loa (eye worm) hypothetical protein 0.0169 0.2533 0.2533
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0273 0.4502 0.6887
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0273 0.4502 0.6545
Brugia malayi Carboxylesterase family protein 0.0216 0.342 0.342
Brugia malayi nuclear receptor NHR-67 0.0129 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.0054 0.0341 0.0341
Loa Loa (eye worm) carboxylesterase 0.0216 0.342 0.342
Loa Loa (eye worm) norepinephrine transporter 0.0262 0.4297 0.4297
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0044 0.0152 0.5
Loa Loa (eye worm) hypothetical protein 0.0273 0.4502 0.4502
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.1681 0.2444
Loa Loa (eye worm) hypothetical protein 0.0216 0.342 0.342
Onchocerca volvulus Bile acid receptor homolog 0.0273 0.4502 1
Schistosoma mansoni nuclear hormone receptor 0.0129 0.1756 0.2553
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0262 0.4297 0.4297
Loa Loa (eye worm) hypothetical protein 0.0044 0.0152 0.0152
Onchocerca volvulus 0.0262 0.4297 0.9544
Echinococcus granulosus RUN 0.006 0.0442 0.0676
Echinococcus multilocularis peroxidasin 0.0057 0.039 0.0567
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0045 0.0153 0.0153
Echinococcus granulosus Ankyrin 0.0045 0.016 0.0245
Echinococcus multilocularis acetylcholinesterase 0.0216 0.342 0.4973
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0052 0.0289 0.0441
Loa Loa (eye worm) hypothetical protein 0.0144 0.205 0.205
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0144 0.205 0.3136
Echinococcus granulosus pikachurin 0.005 0.0255 0.039
Echinococcus multilocularis thyroid hormone receptor alpha 0.0398 0.6878 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0152 0.0152
Echinococcus granulosus mitogen activated protein kinase 11 0.0136 0.1905 0.2913
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0273 0.4502 0.6545
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0044 0.0152 0.0221
Brugia malayi nuclear hormone receptor 0.0273 0.4502 0.4502
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0273 0.4502 0.6545
Plasmodium vivax multidomain scavenger receptor, putative 0.006 0.0442 1
Mycobacterium ulcerans glutaminase 0.0266 0.4366 1
Schistosoma mansoni laminin gamma-3 chain 0.0068 0.0606 0.0881
Echinococcus granulosus intermediate filament protein 0.0055 0.0361 0.0552
Brugia malayi hypothetical protein 0.0137 0.1911 0.1911
Onchocerca volvulus Netrin receptor homolog 0.0045 0.0153 0.0339
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Echinococcus granulosus sodium and chloride dependent glycine 0.0044 0.0152 0.0233
Onchocerca volvulus 0.006 0.0442 0.0981
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Echinococcus multilocularis slit 2 protein 0.0068 0.0606 0.0881
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0044 0.0152 0.0221
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0144 0.205 0.205
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0045 0.0153 0.0234
Brugia malayi P38 map kinase family protein 2 0.0136 0.1905 0.1905
Entamoeba histolytica hypothetical protein 0.0072 0.0671 1
Onchocerca volvulus 0.0057 0.039 0.0867
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0052 0.0289 0.0419
Brugia malayi Blistered cuticle protein 3 0.0057 0.039 0.039
Echinococcus multilocularis nuclear receptor nhr 48 0.0129 0.1756 0.2553
Echinococcus granulosus insulin receptor 0.0052 0.0289 0.0441
Loa Loa (eye worm) hypothetical protein 0.0044 0.0152 0.0152
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0044 0.0152 0.0233
Schistosoma mansoni tyrosine kinase 0.0052 0.0289 0.0419
Onchocerca volvulus 0.0273 0.4502 1
Schistosoma mansoni tyrosine kinase 0.0162 0.2384 0.3466
Echinococcus multilocularis mitogen activated protein kinase 14 0.0136 0.1905 0.2769
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0527 0.0806
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.3564 1
Loa Loa (eye worm) hypothetical protein 0.0273 0.4502 0.4502
Schistosoma mansoni netrin receptor unc5 0.0045 0.0153 0.0222
Echinococcus granulosus death domain containing protein 0.0045 0.0153 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0273 0.4502 0.4502
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Loa Loa (eye worm) TK/INSR protein kinase 0.0052 0.0289 0.0289
Echinococcus granulosus epidermal growth factor receptor 0.0162 0.2384 0.3646
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0527 0.0766
Brugia malayi Death domain containing protein 0.0045 0.0153 0.0153
Schistosoma mansoni tyrosine kinase 0.0086 0.0942 0.1369
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0273 0.4502 0.6545
Brugia malayi intermediate filament protein 0.0055 0.0361 0.0361
Brugia malayi Cytochrome P450 family protein 0.0054 0.0339 0.0339
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0144 0.205 0.2981
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.039 0.039
Toxoplasma gondii hypothetical protein 0.0044 0.0152 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.0361 0.0361
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0361 0.0361
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0174 0.2624 0.3814
Schistosoma mansoni nuclear hormone receptor 0.0273 0.4502 0.6545
Brugia malayi nuclear receptor RXR 0.0144 0.205 0.205
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0129 0.1756 0.2553
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0273 0.4502 0.4502
Brugia malayi Animal haem peroxidase family protein 0.0057 0.039 0.039
Brugia malayi Animal haem peroxidase family protein 0.0057 0.039 0.039
Echinococcus multilocularis serotonin transporter 0.0262 0.4297 0.6247
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0273 0.4502 0.4502
Echinococcus multilocularis epidermal growth factor receptor 0.0162 0.2384 0.3466
Loa Loa (eye worm) steroid hormone receptor 0.0273 0.4502 0.4502
Echinococcus granulosus Polycystic kidney disease protein 0.006 0.0442 0.0676
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0228 0.3651 0.5307
Loa Loa (eye worm) hypothetical protein 0.0068 0.0606 0.0606
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0044 0.0152 0.0221
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0144 0.205 0.2981
Schistosoma mansoni hypothetical protein 0.005 0.0262 0.0381
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0339 0.0339
Onchocerca volvulus 0.0129 0.1756 0.3901
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0262 0.4297 0.6247
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Plasmodium falciparum LCCL domain-containing protein 0.006 0.0442 1
Schistosoma mansoni ankyrin 23/unc44 0.0045 0.0153 0.0222
Schistosoma mansoni cell polarity protein 0.005 0.0255 0.0371
Brugia malayi nuclear receptor NHR-88 0.0273 0.4502 0.4502
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0273 0.4502 0.4502
Onchocerca volvulus Peroxidasin homolog 0.0057 0.039 0.0867
Loa Loa (eye worm) hypothetical protein 0.0262 0.4297 0.4297
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0273 0.4502 0.4502
Loa Loa (eye worm) solute carrier family 6 member 4 0.0262 0.4297 0.4297
Loa Loa (eye worm) hypothetical protein 0.005 0.0255 0.0255
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0044 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.006 0.0442 0.0442
Brugia malayi Steroid receptor seven-up type 2 0.0273 0.4502 0.4502
Schistosoma mansoni tyrosine kinase 0.0086 0.0942 0.1369
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0129 0.1756 0.3901
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0044 0.0152 0.0152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0273 0.4502 0.6545
Onchocerca volvulus 0.0055 0.0361 0.0801
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0153 0.0153
Echinococcus multilocularis epidermal growth factor receptor 0.0087 0.0959 0.1394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0273 0.4502 0.4502
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0671 0.0976
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.005 0.0255 0.0371
Echinococcus multilocularis sodium and chloride dependent glycine 0.0044 0.0152 0.0221
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0044 0.0152 0.0221
Loa Loa (eye worm) blistered cuticle protein 3 0.0057 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Schistosoma mansoni sodium-dependent amino acid transporter 0.0044 0.0152 0.0221
Brugia malayi Uncoordinated protein 44 0.0045 0.0153 0.0153
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0045 0.0153 0.0222
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0273 0.4502 0.4502
Schistosoma mansoni thyroid hormone receptor 0.0398 0.6878 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0044 0.0152 0.0233
Echinococcus multilocularis geminin 0.0165 0.2442 0.3551
Brugia malayi hypothetical protein 0.006 0.0442 0.0442
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0442 0.0642
Schistosoma mansoni hypothetical protein 0.006 0.0442 0.0642
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Onchocerca volvulus 0.0055 0.0361 0.0801
Loa Loa (eye worm) hypothetical protein 0.0216 0.342 0.342
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0273 0.4502 0.4502
Loa Loa (eye worm) hypothetical protein 0.0044 0.0152 0.0152
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0273 0.4502 0.6887
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0044 0.0152 0.0221
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0671 0.0976
Onchocerca volvulus Protein ultraspiracle homolog 0.0273 0.4502 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0273 0.4502 0.6545
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0273 0.4502 0.6545
Schistosoma mansoni hypothetical protein 0.0072 0.0671 0.0976
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0273 0.4502 1
Loa Loa (eye worm) hypothetical protein 0.0477 0.8393 0.8393
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0273 0.4502 0.6887
Entamoeba histolytica hypothetical protein 0.0072 0.0671 1
Echinococcus granulosus lamin dm0 0.0055 0.0361 0.0552
Schistosoma mansoni hypothetical protein 0.0045 0.0153 0.0222
Loa Loa (eye worm) hypothetical protein 0.0144 0.205 0.205
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0129 0.1756 0.2553
Echinococcus granulosus slit 2 protein 0.0068 0.0606 0.0927
Echinococcus granulosus acetylcholinesterase 0.0216 0.342 0.5232
Brugia malayi hypothetical protein 0.0129 0.1756 0.1756
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0129 0.1756 0.2553
Schistosoma mansoni sodium/chloride dependent transporter 0.0262 0.4297 0.6247
Echinococcus granulosus netrin receptor unc 5 0.0045 0.0153 0.0234
Loa Loa (eye worm) doublecortin family protein 0.006 0.0442 0.0442
Brugia malayi conserved hypotetical protein 0.0129 0.1756 0.1756
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0361 0.0361
Schistosoma mansoni nuclear hormone receptor 0.0129 0.1756 0.2553
Schistosoma mansoni thyroid hormone receptor 0.0398 0.6878 1
Echinococcus granulosus neurogenic locus notch protein 0.005 0.0255 0.039
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0044 0.0152 0.0233
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Brugia malayi hypothetical protein 0.0057 0.039 0.039
Brugia malayi hypothetical protein 0.006 0.0442 0.0442
Onchocerca volvulus Chorion peroxidase homolog 0.0057 0.039 0.0867
Schistosoma mansoni tyrosine kinase 0.0087 0.0959 0.1394
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0273 0.4502 0.4502
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0136 0.1905 1
Schistosoma mansoni rab6-interacting 0.006 0.0442 0.0642
Echinococcus granulosus jun protein 0.0174 0.2624 0.4013
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Echinococcus granulosus peroxidasin 0.0057 0.039 0.0597
Brugia malayi hypothetical protein 0.0144 0.205 0.205
Loa Loa (eye worm) hypothetical protein 0.0273 0.4502 0.4502
Echinococcus multilocularis mitogen activated protein kinase 14 0.0136 0.1905 0.2769
Brugia malayi Animal haem peroxidase family protein 0.0057 0.039 0.039
Echinococcus multilocularis Ankyrin 0.0045 0.016 0.0232
Treponema pallidum sodium- and chloride- dependent transporter 0.0262 0.4297 0.5
Loa Loa (eye worm) hypothetical protein 0.0262 0.4297 0.4297
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.039 0.039
Brugia malayi nuclear hormone receptor family member odr-7 0.0129 0.1756 0.1756
Brugia malayi EGF-like domain containing protein 0.0068 0.0606 0.0606
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0012 0.0018
Loa Loa (eye worm) glutaminase 0.0266 0.4366 0.4366
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0273 0.4502 0.4502
Echinococcus granulosus Nuclear hormone receptor HR96 0.0129 0.1756 0.2687
Onchocerca volvulus 0.0044 0.0152 0.0338
Schistosoma mansoni tyrosine kinase 0.0087 0.0959 0.1394
Brugia malayi Nuclear hormone receptor-like 1 0.0144 0.205 0.205
Echinococcus multilocularis mitogen activated protein kinase 11 0.0136 0.1905 0.2769
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Schistosoma mansoni jun-related protein 0.0142 0.2002 0.291
Loa Loa (eye worm) hypothetical protein 0.0273 0.4502 0.4502
Loa Loa (eye worm) hypothetical protein 0.0262 0.4297 0.4297
Schistosoma mansoni nuclear receptor 0.0129 0.1756 0.2553
Schistosoma mansoni tyrosine kinase 0.0086 0.0942 0.1369
Loa Loa (eye worm) hypothetical protein 0.0045 0.016 0.016
Echinococcus granulosus nuclear factor of activated T cells 5 0.0228 0.3649 0.5581
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0044 0.0152 0.0221
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.039 0.039
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0044 0.0152 0.0221
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0273 0.4502 0.6545
Loa Loa (eye worm) hypothetical protein 0.0273 0.4502 0.4502
Echinococcus granulosus lamin 0.0055 0.0361 0.0552
Schistosoma mansoni lipoxygenase 0.0228 0.3651 0.5307
Brugia malayi nuclear receptor RXR 0.0129 0.1756 0.1756
Echinococcus multilocularis sodium and chloride dependent glycine 0.0044 0.0152 0.0221
Brugia malayi tailless protein 0.0129 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.0477 0.8393 0.8393
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Brugia malayi nuclear hormone receptor 0.0129 0.1756 0.1756
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0136 0.1905 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.1681 0.2571
Brugia malayi Animal haem peroxidase family protein 0.0057 0.039 0.039
Echinococcus multilocularis ecdysone induced protein 78C 0.0273 0.4502 0.6545
Trichomonas vaginalis glutaminase, putative 0.0266 0.4366 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0273 0.4502 0.6545
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0273 0.4502 0.6545
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0129 0.1756 0.3901
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0044 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0044 0.0152 0.0152
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0527 0.0527
Schistosoma mansoni sodium/chloride dependent transporter 0.0044 0.0152 0.0221
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0.0152 0.5
Onchocerca volvulus Dual oxidase homolog 0.0057 0.039 0.0867
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Onchocerca volvulus Peroxidase homolog 0.0057 0.039 0.0867
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0136 0.1905 0.1905
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0136 0.1905 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0129 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.0144 0.205 0.205
Echinococcus multilocularis netrin receptor unc 5 0.0045 0.0153 0.0222
Schistosoma mansoni polycystin 1-related 0.006 0.0442 0.0642
Echinococcus multilocularis mitogen activated protein kinase 11 0.0136 0.1905 0.2769
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0273 0.4502 0.6887
Echinococcus multilocularis carboxylesterase 5A 0.0216 0.342 0.4973
Loa Loa (eye worm) glutaminase 2 0.0266 0.4366 0.4366
Onchocerca volvulus 0.0044 0.0152 0.0338
Brugia malayi steroid hormone receptor 0.0273 0.4502 0.4502
Echinococcus multilocularis musashi 0.0055 0.0361 0.0524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0273 0.4502 0.4502
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Echinococcus granulosus epidermal growth factor receptor 0.0087 0.0959 0.1467
Schistosoma mansoni sodium/chloride dependent transporter 0.0045 0.0162 0.0235
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0044 0.0152 0.0152
Schistosoma mansoni peroxidasin 0.0057 0.039 0.0567
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0136 0.1905 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Brugia malayi laminin-like protein K08C7.3 precursor 0.005 0.0255 0.0255
Brugia malayi Animal haem peroxidase family protein 0.0057 0.039 0.039
Brugia malayi glutaminase DH11.1 0.0266 0.4366 0.4366
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0129 0.1756 0.1756
Echinococcus granulosus mitogen activated protein kinase 14 0.0136 0.1905 0.2913
Echinococcus granulosus retinoic acid receptor rxr beta a 0.038 0.6537 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0044 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Brugia malayi ecdysteroid receptor 0.0273 0.4502 0.4502
Echinococcus multilocularis 0.005 0.0258 0.0375
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0044 0.0152 0.0221
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0273 0.4502 0.6545
Schistosoma mansoni steroid hormone receptor ad4bp 0.0273 0.4502 0.6545
Echinococcus granulosus Nuclear hormone receptor HR96 0.0129 0.1756 0.2687
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0442 0.0676
Loa Loa (eye worm) hypothetical protein 0.0045 0.0153 0.0153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0129 0.1756 0.2687
Loa Loa (eye worm) hypothetical protein 0.0044 0.0152 0.0152
Onchocerca volvulus 0.0137 0.1911 0.4245
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0527 0.0527
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0228 0.3649 0.5305
Loa Loa (eye worm) hypothetical protein 0.0273 0.4502 0.4502
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0.0152 0.5
Loa Loa (eye worm) acetylcholinesterase 1 0.0216 0.342 0.342
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0273 0.4502 0.4502
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0236 0.3792 0.5512
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0129 0.1756 0.2553
Echinococcus multilocularis Polycystic kidney disease protein 0.006 0.0442 0.0642
Brugia malayi nuclear receptor NHR-88 0.0129 0.1756 0.1756
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0044 0.0152 0.0152
Brugia malayi hypothetical protein 0.0144 0.205 0.205
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Onchocerca volvulus Peroxidasin homolog 0.0057 0.039 0.0867
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0044 0.0152 0.5
Schistosoma mansoni coup transcription factor 0.0273 0.4502 0.6545
Schistosoma mansoni hypothetical protein 0.0125 0.1681 0.2444
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0527 0.0766
Schistosoma mansoni nuclear receptor 0.0129 0.1756 0.2553
Echinococcus multilocularis acetylcholinesterase 0.0216 0.342 0.4973
Echinococcus granulosus acetylcholinesterase 0.0216 0.342 0.5232
Brugia malayi Nuclear hormone receptor E75 0.0129 0.1756 0.1756
Echinococcus multilocularis pikachurin 0.005 0.0255 0.0371
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0044 0.0152 0.0233
Brugia malayi Peroxidasin 0.0057 0.039 0.039
Brugia malayi nuclear hormone receptor family member nhr-6 0.0129 0.1756 0.1756
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0273 0.4502 0.6887
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0129 0.1756 0.2553
Loa Loa (eye worm) TK/EGFR protein kinase 0.0162 0.2384 0.2384
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0129 0.1756 0.2687
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0273 0.4502 0.4502
Schistosoma mansoni tyrosine kinase 0.0052 0.0289 0.0419
Schistosoma mansoni intermediate filament proteins 0.0055 0.0361 0.0524
Echinococcus granulosus thyroid hormone receptor alpha 0.0129 0.1756 0.2687
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0129 0.1756 0.2553
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0087 0.0959 0.1467
Brugia malayi Protein kinase domain containing protein 0.0052 0.0289 0.0289
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0273 0.4502 0.4502
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0273 0.4502 0.4502
Brugia malayi orphan nuclear receptor NR2E1 0.0129 0.1756 0.1756
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0012 0.0019
Loa Loa (eye worm) serotonin transporter b 0.0262 0.4297 0.4297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0273 0.4502 0.4502
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Brugia malayi Doublecortin family protein 0.006 0.0442 0.0442
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0671 0.1027
Brugia malayi Nuclear hormone receptor E75 0.0129 0.1756 0.1756
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0273 0.4502 0.4502
Loa Loa (eye worm) hypothetical protein 0.0144 0.205 0.205
Schistosoma mansoni hypothetical protein 0.0165 0.2442 0.3551
Schistosoma mansoni RAR-like nuclear receptor 0.0273 0.4502 0.6545
Schistosoma mansoni retinoic acid receptor RXR 0.038 0.6537 0.9504
Brugia malayi Serotonin receptor 0.0527 0.9343 0.9343
Schistosoma mansoni peroxidasin 0.0057 0.039 0.0567
Echinococcus granulosus nuclear receptor nhr 48 0.0129 0.1756 0.2687
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Schistosoma mansoni slit 0.0068 0.0606 0.0881
Echinococcus granulosus sodium and chloride dependent glycine 0.0044 0.0152 0.0233
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0273 0.4502 0.6887
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Loa Loa (eye worm) nuclear hormone receptor 0.0129 0.1756 0.1756
Echinococcus multilocularis FTZ F1 alpha 0.0273 0.4502 0.6545
Schistosoma mansoni lamin 0.0055 0.0361 0.0524
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.005 0.0255 0.0255
Brugia malayi bZIP transcription factor family protein 0.0174 0.2624 0.2624
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0273 0.4502 0.6545
Loa Loa (eye worm) animal heme peroxidase 0.0057 0.039 0.039
Echinococcus multilocularis RUN 0.006 0.0442 0.0642
Schistosoma mansoni zinc finger protein 0.0129 0.1756 0.2553
Onchocerca volvulus 0.0057 0.039 0.0867
Schistosoma mansoni rab6-interacting 0.006 0.0442 0.0642
Brugia malayi hypothetical protein 0.0044 0.0152 0.0152
Brugia malayi photoreceptor-specific nuclear receptor 0.0273 0.4502 0.4502
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Onchocerca volvulus Peroxidase homolog 0.0057 0.039 0.0867
Onchocerca volvulus 0.0044 0.0152 0.0338
Echinococcus multilocularis lamin 0.0055 0.0361 0.0524
Loa Loa (eye worm) hypothetical protein 0.005 0.0255 0.0255
Brugia malayi Carboxylesterase family protein 0.0216 0.342 0.342
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.0442 0.0642
Onchocerca volvulus 0.0129 0.1756 0.3901
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.0442 0.0676
Echinococcus multilocularis lamin dm0 0.0055 0.0361 0.0524
Brugia malayi Furin-like cysteine rich region family protein 0.0162 0.2384 0.2384
Loa Loa (eye worm) hypothetical protein 0.0273 0.4502 0.4502
Brugia malayi laminin alpha chain 0.005 0.0255 0.0255
Echinococcus multilocularis neurogenic locus notch protein 0.005 0.0255 0.0371
Brugia malayi hypothetical protein 0.0129 0.1756 0.1756
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0273 0.4502 0.4502
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0228 0.3651 0.5584
Brugia malayi ecdysone receptor 0.0129 0.1756 0.1756
Onchocerca volvulus 0.006 0.0442 0.0981
Schistosoma mansoni glutaminase 0.0266 0.4366 0.6348
Loa Loa (eye worm) hypothetical protein 0.0057 0.039 0.039
Loa Loa (eye worm) abnormal epIthelia family member 0.005 0.0255 0.0255
Echinococcus multilocularis jun protein 0.0174 0.2624 0.3814
Entamoeba histolytica hypothetical protein 0.0072 0.0671 1
Echinococcus granulosus geminin 0.0165 0.2442 0.3736
Loa Loa (eye worm) hypothetical protein 0.0144 0.205 0.205
Brugia malayi Nuclear hormone receptor-like 1 0.0144 0.205 0.205
Schistosoma mansoni hypothetical protein 0.0165 0.2442 0.3551
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0174 0.2624 0.4013
Loa Loa (eye worm) DR-78 0.0129 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.0561 1 1
Echinococcus granulosus serotonin transporter 0.0262 0.4297 0.6573
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0216 0.342 0.4973
Loa Loa (eye worm) hypothetical protein 0.006 0.0442 0.0442
Schistosoma mansoni loxhd1 0.006 0.0442 0.0642
Echinococcus granulosus ecdysone induced protein 78C 0.0273 0.4502 0.6887
Echinococcus granulosus carboxylesterase 5A 0.0216 0.342 0.5232
Toxoplasma gondii hypothetical protein 0.0044 0.0152 0.5
Schistosoma mansoni hypothetical protein 0.0142 0.2002 0.291
Brugia malayi Protein kinase domain containing protein 0.0045 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0129 0.1756 0.1756
Entamoeba histolytica hypothetical protein 0.0072 0.0671 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0152 0.0152
Echinococcus granulosus FTZ F1 alpha 0.0273 0.4502 0.6887
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0044 0.0152 0.0221
Brugia malayi hypothetical protein 0.0072 0.0671 0.0671
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0045 0.016 0.0232
Schistosoma mansoni lipoxygenase 0.0121 0.1603 0.2331
Loa Loa (eye worm) hypothetical protein 0.0273 0.4502 0.4502
Schistosoma mansoni lamin 0.0055 0.0361 0.0524
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0044 0.0152 0.0221
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0361 0.0361
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0044 0.0152 0.0221
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0273 0.4502 0.4502
Brugia malayi Nuclear hormone receptor-like 1 0.0273 0.4502 0.4502
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0273 0.4502 0.4502
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0129 0.1756 0.1756

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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