TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 271.397 | Formula: C18H25NO
H donors: 2 H acceptors: 1 LogP: 3.58 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Nc1ccc2c(c1)[C@H]1CC[C@]3([C@H]([C@@H]1CC2)CCC3O)C
InChi: 1S/C18H25NO/c1-18-9-8-13-14(16(18)6-7-17(18)20)5-3-11-2-4-12(19)10-15(11)13/h2,4,10,13-14,16-17,20H,3,5-9,19H2,1H3/t13-,14+,16-,17?,18-/m0/s1
InChiKey: UJZXODRFSBQSSL-URZDDQNSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Estrogen sulfotransferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sulfotransferase domain containing protein	Estrogen sulfotransferase	295 aa	273 aa	27.8 %
Loa Loa (eye worm)	sulfotransferase domain-containing protein	Estrogen sulfotransferase	295 aa	269 aa	29.7 %
Mycobacterium ulcerans	glycolipid sulfotransferase	Estrogen sulfotransferase	295 aa	275 aa	22.2 %
Mycobacterium ulcerans	glycolipid sulfotransferase	Estrogen sulfotransferase	295 aa	305 aa	20.0 %
Mycobacterium tuberculosis	Glycolipid sulfotransferase	Estrogen sulfotransferase	295 aa	285 aa	21.4 %
Onchocerca volvulus		Estrogen sulfotransferase	295 aa	273 aa	28.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	prenyl decaprenyl diphosphate synthase	0.0155	0.1075	0.0867
Brugia malayi	Variant SH3 domain containing protein	0.0078	0.0248	0.0021
Entamoeba histolytica	hexokinase 2	0.008	0.0274	0.0546
Schistosoma mansoni	nck2/grb4	0.0154	0.1062	0.0855
Brugia malayi	Carboxylesterase family protein	0.0986	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Echinococcus granulosus	tyrosine protein kinase Blk	0.01	0.0483	0.0261
Trypanosoma cruzi	farnesyl pyrophosphate synthase, putative	0.0536	0.517	0.768
Brugia malayi	SH2 domain containing protein	0.0078	0.0248	0.0021
Brugia malayi	SH2 domain containing protein	0.0078	0.0248	0.0021
Onchocerca volvulus		0.0078	0.0248	0.0213
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0175	0.1297	0.1094
Brugia malayi	map kinase activated protein kinase protein 2	0.0422	0.3939	0.3798
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Loa Loa (eye worm)	hexokinase	0.008	0.0274	0.0274
Loa Loa (eye worm)	polyprenyl synthetase	0.0536	0.517	0.517
Plasmodium falciparum	V-type H(+)-translocating pyrophosphatase, putative	0.0675	0.6663	1
Echinococcus granulosus	tyrosine protein kinase shark	0.01	0.0483	0.0261
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0175	0.1297	0.1094
Brugia malayi	Tensin	0.0078	0.0248	0.0021
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0422	0.3939	0.3939
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0167	0.1202	0.0997
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0175	0.1297	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Loa Loa (eye worm)	TK protein kinase	0.01	0.0483	0.0483
Onchocerca volvulus		0.01	0.0483	0.2619
Echinococcus granulosus	c src tyrosine kinase	0.0175	0.1297	0.1094
Echinococcus granulosus	tyrosine protein kinase Srms	0.01	0.0483	0.0261
Entamoeba histolytica	protein kinase, putative	0.0079	0.026	0.0381
Echinococcus multilocularis	N chimaerin	0.0078	0.0248	0.0021
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.01	0.0483	0.3012
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Schistosoma mansoni	tyrosine kinase	0.0175	0.1297	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0227	0.0227
Brugia malayi	protein-tyrosine kinase	0.01	0.0483	0.0261
Onchocerca volvulus		0.0167	0.1202	1
Brugia malayi	Carboxylesterase family protein	0.0167	0.1202	0.0997
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0154	0.1062	0.0855
Onchocerca volvulus		0.0167	0.1202	1
Trypanosoma cruzi	vacuolar-type proton translocating pyrophosphatase 1	0.0675	0.6663	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0078	0.0248	0.0021
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0175	0.1297	0.1094
Loa Loa (eye worm)	hexokinase	0.008	0.0274	0.0274
Trypanosoma cruzi	hexokinase, putative	0.008	0.0274	0.0072
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.01	0.0483	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Echinococcus granulosus	neuroligin	0.0167	0.1202	0.0997
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0078	0.0248	0.0021
Echinococcus multilocularis	SH2 motif	0.0078	0.0248	0.0021
Brugia malayi	SH2 domain containing protein	0.01	0.0483	0.0261
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0078	0.0248	0.0021
Echinococcus granulosus	decaprenyl diphosphate synthase subunit 1	0.0155	0.1075	0.0867
Brugia malayi	SH2 domain containing protein	0.0078	0.0248	0.0021
Schistosoma mansoni	hypothetical protein	0.0078	0.0248	0.0021
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0078	0.0248	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Echinococcus multilocularis	SH2 motif	0.0078	0.0248	0.0021
Schistosoma mansoni	tyrosine kinase	0.0175	0.1297	0.1094
Brugia malayi	Protein kinase domain containing protein	0.01	0.0483	0.0261
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0167	0.1202	0.1972
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1202	0.1202
Plasmodium vivax	geranylgeranyl pyrophosphate synthase	0.0536	0.517	0.7663
Brugia malayi	Sex muscle abnormal protein 5	0.0154	0.1062	0.0855
Onchocerca volvulus		0.01	0.0483	0.2619
Echinococcus multilocularis	signal transduction protein lnk realted	0.0078	0.0248	0.0021
Schistosoma mansoni	hexokinase	0.008	0.0274	0.0047
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0175	0.1297	0.1094
Schistosoma mansoni	tyrosine kinase	0.0175	0.1297	0.1094
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0175	0.1297	0.1094
Onchocerca volvulus		0.0078	0.0248	0.0213
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0248	0.0021
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.01	0.0483	0.0261
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.01	0.0483	0.0261
Onchocerca volvulus		0.0077	0.0239	0.0119
Schistosoma mansoni	adapter molecule crk	0.0154	0.1062	0.0855
Echinococcus granulosus	tensin	0.0078	0.0248	0.0021
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0248	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0227	0.0227
Schistosoma mansoni	BC026374 protein (S09 family)	0.0167	0.1202	0.0997
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Schistosoma mansoni	tyrosine kinase	0.01	0.0483	0.0261
Schistosoma mansoni	growth factor receptor-bound protein	0.0154	0.1062	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Plasmodium vivax	V-type H(+)-translocating pyrophosphatase, putative	0.0675	0.6663	1
Onchocerca volvulus		0.008	0.0274	0.0475
Loa Loa (eye worm)	protein kinase C and casein kinase substrate in neurons protein 2	0.0076	0.0227	0.0227
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0078	0.0248	0.0021
Schistosoma mansoni	glutathione synthetase	0.0155	0.1075	0.0867
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0227	0.0227
Schistosoma mansoni	gliotactin	0.0167	0.1202	0.0997
Loa Loa (eye worm)	SH2 domain-containing protein	0.0078	0.0248	0.0248
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0078	0.0248	0.0021
Echinococcus multilocularis	tensin	0.0078	0.0248	0.0021
Echinococcus granulosus	farnesyl pyrophosphate synthase	0.0536	0.517	0.5057
Schistosoma mansoni	tyrosine kinase	0.01	0.0483	0.0261
Echinococcus multilocularis	tyrosine protein kinase Blk	0.01	0.0483	0.0261
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0175	0.1297	0.1094
Echinococcus multilocularis	tensin	0.0078	0.0248	0.0021
Trypanosoma cruzi	farnesyl pyrophosphate synthase	0.0536	0.517	0.768
Loa Loa (eye worm)	carboxylesterase	0.0167	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0986	1	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0078	0.0248	0.0021
Onchocerca volvulus		0.0167	0.1202	1
Schistosoma mansoni	tensin	0.0078	0.0248	0.0021
Giardia lamblia	Farnesyl diphosphate synthase	0.0536	0.517	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.0462	0.024
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0227	0.0227
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0167	0.1202	0.0997
Schistosoma mansoni	hypothetical protein	0.0078	0.0248	0.0021
Onchocerca volvulus		0.0078	0.0248	0.0213
Echinococcus multilocularis	hexokinase	0.008	0.0274	0.0047
Echinococcus granulosus	N chimaerin	0.0078	0.0248	0.0021
Trypanosoma brucei	Pyrophosphate-energized vacuolar membrane proton pump 1	0.0675	0.6663	1
Brugia malayi	Variant SH3 domain containing protein	0.0078	0.0248	0.0021
Echinococcus multilocularis	NCK adaptor protein	0.0154	0.1062	0.0855
Leishmania major	farnesyl pyrophosphate synthase	0.0536	0.517	0.768
Loa Loa (eye worm)	hypothetical protein	0.0986	1	1
Onchocerca volvulus		0.0078	0.0248	0.0213
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0167	0.1202	0.031
Echinococcus granulosus	growth factor receptor bound protein 2	0.0154	0.1062	0.0855
Schistosoma mansoni	tensin	0.0078	0.0248	0.0021
Echinococcus granulosus	hexokinase	0.008	0.0274	0.0047
Echinococcus granulosus	carboxylesterase 5A	0.0986	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0078	0.0248	0.0021
Echinococcus multilocularis	carboxylesterase 5A	0.0986	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0078	0.0248	0.0248
Echinococcus granulosus	SHC transforming protein 3	0.0078	0.0248	0.0021
Loa Loa (eye worm)	p53BP2	0.0076	0.0227	0.0227
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0078	0.0248	0.0021
Trypanosoma cruzi	hexokinase, putative	0.008	0.0274	0.0072
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0175	0.1297	0.1094
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0986	1	1
Schistosoma mansoni	farnesyl pyrophosphate synthase	0.0536	0.517	0.5057
Echinococcus multilocularis	neuroligin	0.0167	0.1202	0.0997
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0078	0.0248	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Schistosoma mansoni	serine/threonine protein kinase	0.0422	0.3939	0.3798
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0154	0.1062	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0227	0.0227
Brugia malayi	SH2 domain containing protein	0.0078	0.0248	0.0021
Echinococcus granulosus	hexokinase	0.008	0.0274	0.0047
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.0155	0.1075	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0175	0.1297	0.1094
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0078	0.0248	0.0213
Mycobacterium ulcerans	carboxylesterase, LipT	0.0167	0.1202	0.031
Trypanosoma cruzi	solanesyl-diphosphate synthase	0.0155	0.1075	0.1317
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0175	0.1297	0.1094
Mycobacterium leprae	PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE)	0.0155	0.1075	0.5
Echinococcus granulosus	acetylcholinesterase	0.0986	1	1
Trypanosoma brucei	Pyrophosphate-energized vacuolar membrane proton pump 2, putative	0.0675	0.6663	1
Echinococcus multilocularis	tyrosine kinase	0.01	0.0483	0.0261
Loa Loa (eye worm)	carboxylesterase	0.0986	1	1
Echinococcus granulosus	SH2 motif	0.0078	0.0248	0.0021
Onchocerca volvulus		0.01	0.0483	0.2619
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Entamoeba histolytica	SH2 domain containing protein	0.0078	0.0248	0.0245
Schistosoma mansoni	GTPase activating protein	0.0078	0.0248	0.0021
Brugia malayi	Protein kinase domain containing protein	0.01	0.0483	0.0261
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0177	0.1308	0.1106
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0078	0.0248	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Echinococcus multilocularis		0.0078	0.0248	0.0021
Loa Loa (eye worm)	SH2 domain-containing protein	0.0078	0.0248	0.0248
Treponema pallidum	octaprenyl-diphosphate synthase	0.0235	0.1935	1
Entamoeba histolytica	bifunctional short chain isoprenyl diphosphate synthase, putative	0.0155	0.1075	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1062	0.1062
Echinococcus granulosus	hypothetical protein	0.0078	0.0248	0.0021
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0078	0.0248	0.0021
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0167	0.1202	0.0997
Chlamydia trachomatis	geranylgeranyl pyrophosphate synthase	0.0155	0.1075	0.5
Brugia malayi	Protein kinase domain containing protein	0.01	0.0483	0.0261
Schistosoma mansoni	tensin-related	0.0078	0.0248	0.0021
Echinococcus granulosus	geranylgeranyl pyrophosphate synthase	0.0235	0.1935	0.1747
Schistosoma mansoni	tyrosine kinase	0.0175	0.1297	0.1094
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.0155	0.1075	0.1254
Echinococcus multilocularis	geranylgeranyl pyrophosphate synthase	0.0235	0.1935	0.1747
Loa Loa (eye worm)	polyprenyl synthetase	0.0155	0.1075	0.1075
Entamoeba histolytica	geranylgeranyl pyrophosphate synthetase, putative	0.0155	0.1075	1
Entamoeba histolytica	hexokinase 1	0.008	0.0274	0.0546
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.01	0.0483	0.0261
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.0536	0.517	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0167	0.1202	0.0997
Schistosoma mansoni	signal transduction protein lnk-related	0.0078	0.0248	0.0021
Leishmania major	hexokinase, putative	0.008	0.0274	0.0072
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0078	0.0248	0.0021
Schistosoma mansoni	geranylgeranyl pyrophosphate synthase	0.0235	0.1935	0.1747
Brugia malayi	hypothetical protein	0.01	0.0483	0.0261
Brugia malayi	Protein kinase domain containing protein	0.01	0.0483	0.0261
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.0536	0.517	1
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0078	0.0248	0.0021
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0078	0.0248	0.0213
Echinococcus multilocularis	acetylcholinesterase	0.0986	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0078	0.0248	0.0021
Echinococcus multilocularis	hexokinase	0.008	0.0274	0.0047
Plasmodium falciparum	geranylgeranyl pyrophosphate synthase, putative	0.0536	0.517	0.7663
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0078	0.0248	0.0248
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0078	0.0248	0.0021
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0155	0.1075	0.1317
Brugia malayi	SRC-1	0.0175	0.1297	0.1094
Echinococcus granulosus	signal transduction protein lnk realted	0.0078	0.0248	0.0021
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0175	0.1297	0.1094
Onchocerca volvulus		0.0167	0.1202	1
Loa Loa (eye worm)	acetylcholinesterase 1	0.0986	1	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0079	0.026	0.0381
Echinococcus granulosus	tyrosine kinase	0.01	0.0483	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Loa Loa (eye worm)	STAT protein	0.0078	0.0248	0.0248
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0422	0.3939	0.3798
Brugia malayi	Carboxylesterase family protein	0.0167	0.1202	0.0997
Trypanosoma cruzi	polyprenyl synthase, putative	0.0235	0.1935	0.2654
Toxoplasma gondii	polyprenyl synthetase superfamily protein	0.0536	0.517	0.7663
Trichomonas vaginalis	spcc417.12 protein, putative	0.0167	0.1202	0.1972
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0175	0.1297	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1202	0.1202
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0078	0.0248	0.0021
Trichomonas vaginalis	geranylgeranyl diphosphate synthase, putative	0.0536	0.517	1
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1202	0.1202
Brugia malayi	Variant SH3 domain containing protein	0.0154	0.1062	0.0855
Trypanosoma cruzi	Vacuolar proton pyrophosphatase 1, putative	0.0675	0.6663	1
Brugia malayi	hexokinase	0.008	0.0274	0.0047
Echinococcus granulosus	tyrosine kinase	0.01	0.0483	0.0261
Echinococcus multilocularis	hexokinase type 2	0.008	0.0274	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0227	0.0227
Loa Loa (eye worm)	carboxylesterase	0.0167	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0167	0.1202	0.0997
Leishmania major	vacuolar-type proton translocating pyrophosphatase 1, putative	0.0675	0.6663	1
Schistosoma mansoni	shc transforming protein	0.0078	0.0248	0.0021
Loa Loa (eye worm)	protein-tyrosine kinase	0.0076	0.0227	0.0227
Echinococcus multilocularis	SHC transforming protein 3	0.0078	0.0248	0.0021
Echinococcus granulosus	hexokinase type 2	0.008	0.0274	0.0047
Loa Loa (eye worm)	TK/ABL protein kinase	0.01	0.0483	0.0483
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0078	0.0248	0.0021
Onchocerca volvulus		0.008	0.0274	0.0475
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0422	0.3939	0.3798
Trypanosoma brucei	hexokinase	0.008	0.0274	0.0072
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0076	0.0227	0.0227
Brugia malayi	SH2 domain containing protein	0.01	0.0483	0.0261
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0167	0.1202	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Trypanosoma brucei	hexokinase	0.008	0.0274	0.0072
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0175	0.1297	0.1094
Schistosoma mansoni	acetylcholinesterase	0.0167	0.1202	0.0997
Echinococcus multilocularis	acetylcholinesterase	0.0986	1	1
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Onchocerca volvulus		0.008	0.0274	0.0475
Brugia malayi	hypothetical protein	0.0078	0.0248	0.0021
Echinococcus granulosus	tyrosine protein kinase ABL1	0.01	0.0483	0.0261
Brugia malayi	Carboxylesterase family protein	0.0167	0.1202	0.0997
Onchocerca volvulus		0.0078	0.0248	0.0213
Entamoeba histolytica	geranylgeranyl pyrophosphate synthase, putative	0.0155	0.1075	1
Brugia malayi	SH2 domain containing protein	0.0078	0.0248	0.0021
Trypanosoma cruzi	polyprenyl synthase, putative	0.0235	0.1935	0.2654
Brugia malayi	Protein kinase domain containing protein	0.01	0.0483	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1202	0.1202
Onchocerca volvulus		0.0078	0.0248	0.0213
Onchocerca volvulus		0.01	0.0483	0.2619
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0078	0.0248	0.0021
Loa Loa (eye worm)	SRC-1	0.0175	0.1297	0.1297
Trypanosoma brucei	hexokinase, putative	0.008	0.0274	0.0072
Leishmania major	hexokinase, putative	0.008	0.0274	0.0072
Plasmodium falciparum	V-type K+-independent H+-translocating inorganic pyrophosphatase	0.0675	0.6663	1
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0167	0.1202	0.0997
Brugia malayi	Tyrosine-protein kinase abl-1	0.0175	0.1297	0.1094
Toxoplasma gondii	V-type H(+)-translocating pyrophosphatase VP1	0.0675	0.6663	1
Brugia malayi	Polyprenyl synthetase family protein	0.0536	0.517	0.5057
Onchocerca volvulus		0.0167	0.1202	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.0483	0.0483
Echinococcus multilocularis	prenyl (decaprenyl) diphosphate synthase	0.0155	0.1075	0.0867
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0175	0.1297	0.1094
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0078	0.0248	0.0021
Schistosoma mansoni	vav2	0.0078	0.0248	0.0021
Echinococcus granulosus	BC026374 protein S09 family	0.0167	0.1202	0.0997
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0175	0.1297	0.1094
Echinococcus granulosus	acetylcholinesterase	0.0986	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0154	0.1062	0.1062
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Brugia malayi	RhoGAP domain containing protein	0.0078	0.0248	0.0021
Loa Loa (eye worm)	hexokinase type II	0.008	0.0274	0.0274
Brugia malayi	SH2 domain containing protein	0.0078	0.0248	0.0021
Echinococcus multilocularis	decaprenyl diphosphate synthase subunit 1	0.0155	0.1075	0.0867
Brugia malayi	Variant SH3 domain containing protein	0.0154	0.1062	0.0855
Schistosoma mansoni	tensin	0.0078	0.0248	0.0021
Mycobacterium ulcerans	geranylgeranyl pyrophosphate synthase	0.0536	0.517	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0078	0.0248	0.0021
Loa Loa (eye worm)	TK/FER protein kinase	0.01	0.0483	0.0483
Brugia malayi	Hexokinase family protein	0.008	0.0274	0.0047
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0167	0.1202	0.031
Schistosoma mansoni	tensin-related	0.0078	0.0248	0.0021
Mycobacterium tuberculosis	Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)	0.0536	0.517	1
Loa Loa (eye worm)	guanylate kinase	0.0076	0.0227	0.0227
Trypanosoma cruzi	solanesyl-diphosphate synthase, putative	0.0155	0.1075	0.1317
Leishmania major	solanesyl-diphosphate synthase, putative	0.0155	0.1075	0.1317
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0175	0.1297	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0227	0.0227
Brugia malayi	SH2 domain containing protein	0.0078	0.0248	0.0021
Trypanosoma brucei	farnesyl pyrophosphate synthase	0.0536	0.517	0.768
Onchocerca volvulus		0.01	0.0483	0.2619
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1202	0.1202
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0154	0.1062	0.1062
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0078	0.0248	0.0021
Echinococcus multilocularis	tyrosine protein kinase shark	0.01	0.0483	0.0261
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0175	0.1297	0.1094
Echinococcus granulosus	para nitrobenzyl esterase	0.0167	0.1202	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Loa Loa (eye worm)	SH2 domain-containing protein	0.0078	0.0248	0.0248
Echinococcus granulosus	hexokinase	0.008	0.0274	0.0047
Brugia malayi	hypothetical protein	0.0167	0.1202	0.0997
Trypanosoma brucei	solanesyl-diphosphate synthase, putative	0.0155	0.1075	0.1317
Plasmodium vivax	octaprenyl pyrophosphate synthase, putative	0.0155	0.1075	0.1254
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.01	0.0483	0.0261
Schistosoma mansoni	trans-prenyltransferase	0.0155	0.1075	0.0867
Plasmodium vivax	vacuolar-type H+ pumping pyrophosphatase, putative	0.0675	0.6663	1
Echinococcus multilocularis	farnesyl pyrophosphate synthase	0.0536	0.517	0.5057
Schistosoma mansoni	suppressor of cytokine signaling	0.0078	0.0248	0.0021
Wolbachia endosymbiont of Brugia malayi	geranylgeranyl pyrophosphate synthase	0.0155	0.1075	0.5
Echinococcus granulosus	expressed conserved protein	0.0078	0.0248	0.0021
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0078	0.0248	0.0021
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0175	0.1297	0.1094
Echinococcus granulosus	NCK adaptor protein	0.0154	0.1062	0.0855
Echinococcus granulosus	SH2 motif	0.0078	0.0248	0.0021
Loa Loa (eye worm)	geranylgeranyl pyrophosphate synthetase	0.0235	0.1935	0.1935
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0227	0.0227
Brugia malayi	Carboxylesterase family protein	0.0167	0.1202	0.0997
Schistosoma mansoni	SH2A	0.0078	0.0248	0.0021
Onchocerca volvulus		0.01	0.0483	0.2619
Trichomonas vaginalis	geranylgeranyl pyrophosphate synthase, putative	0.0536	0.517	1
Echinococcus multilocularis	c src tyrosine kinase	0.0175	0.1297	0.1094
Brugia malayi	Polyprenyl synthetase family protein	0.0155	0.1075	0.0867
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0078	0.0248	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0078	0.0248	0.0248
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0175	0.1297	0.1094
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0167	0.1202	0.0997
Plasmodium falciparum	octaprenyl pyrophosphate synthase	0.0155	0.1075	0.1254
Brugia malayi	geranylgeranyl pyrophosphate synthetase	0.0235	0.1935	0.1747
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0175	0.1297	0.1094
Schistosoma mansoni	growth factor receptor-bound protein	0.0154	0.1062	0.0855
Echinococcus multilocularis	hexokinase	0.008	0.0274	0.0047
Echinococcus granulosus	SH2 domain containing protein 7	0.0078	0.0248	0.0021
Loa Loa (eye worm)	thyroid receptor interactor	0.0076	0.0227	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1202	0.1202
Echinococcus multilocularis	tyrosine protein kinase Srms	0.01	0.0483	0.0261
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0078	0.0248	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0167	0.1202	0.1202
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0078	0.0248	0.0248
Leishmania major	polyprenyl synthase, putative	0.0235	0.1935	0.2654
Echinococcus multilocularis	SH2 domain containing protein 7	0.0078	0.0248	0.0021
Echinococcus multilocularis	SH2 motif	0.0078	0.0248	0.0021
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0167	0.1202	0.031

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 7.51 uM	Compound was tested for inhibition of porcine endometrial estrogen sulfotransferase	ChEMBL.	3457954

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1627689

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1473856