Detailed information for compound 1475595

Basic information

Technical information
  • TDR Targets ID: 1475595
  • Name: N-[(2,4-dichlorophenyl)methyl]-4-phenylbutan- 2-amine
  • MW: 308.245 | Formula: C17H19Cl2N
  • H donors: 1 H acceptors: 0 LogP: 5.29 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCc1ccccc1)NCc1ccc(cc1Cl)Cl
  • InChi: 1S/C17H19Cl2N/c1-13(7-8-14-5-3-2-4-6-14)20-12-15-9-10-16(18)11-17(15)19/h2-6,9-11,13,20H,7-8,12H2,1H3
  • InChiKey: OTNJFCYELHWUEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2,4-dichlorophenyl)methyl]-4-phenyl-butan-2-amine
  • (2,4-dichlorobenzyl)-(1-methyl-3-phenyl-propyl)amine
  • STK147578

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.002 0.002
Trypanosoma brucei ISWI complex protein 0.0015 0.0014 0.0516
Onchocerca volvulus Cathepsin F homolog 0.0017 0.002 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.002 1
Brugia malayi Cytochrome P450 family protein 0.0012 0.0004 0.005
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.0252
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0048 0.2397
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.077 0.077
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0048 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.002 0.0252
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.002 0.002
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.002 0.0084
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.0252
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0863
Loa Loa (eye worm) cysteine protease 0.0017 0.002 0.0252
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.006
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0012 0.0147
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0038 0.0038
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.002 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0165 0.8925
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.002 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0048 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0203 0.2634
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Schistosoma mansoni lamin 0.0027 0.0056 0.0234
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0472 0.0472
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.0252
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Onchocerca volvulus Cathepsin L homolog 0.0017 0.002 0.1039
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0167 0.0541 0.2277
Schistosoma mansoni hypothetical protein 0.0067 0.0195 0.082
Schistosoma mansoni hypothetical protein 0.0047 0.0126 0.0532
Leishmania major cathepsin L-like protease 0.0064 0.0185 1
Echinococcus multilocularis musashi 0.0027 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0147 0.0472 0.6129
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.006
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.002 0.002
Brugia malayi intermediate filament protein 0.0027 0.0056 0.0716
Brugia malayi MH2 domain containing protein 0.0117 0.037 0.4796
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0048 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0048 0.2397
Echinococcus multilocularis lamin 0.0027 0.0056 0.0056
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0863
Brugia malayi PHD-finger family protein 0.0024 0.0047 0.0598
Brugia malayi bZIP transcription factor family protein 0.0083 0.0249 0.3223
Brugia malayi hypothetical protein 0.0025 0.0048 0.0611
Onchocerca volvulus 0.0017 0.002 0.1039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.002 0.0083
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0126 0.1634
Brugia malayi Bromodomain containing protein 0.0038 0.0092 0.1193
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0248
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Schistosoma mansoni hypothetical protein 0.0015 0.0014 0.0057
Brugia malayi hypothetical protein 0.0065 0.0187 0.2421
Echinococcus multilocularis muscleblind protein 0.0147 0.0472 0.0472
Schistosoma mansoni survival motor neuron protein 0.0047 0.0126 0.0532
Echinococcus multilocularis cysteine protease 0.0017 0.002 0.002
Onchocerca volvulus 0.0017 0.002 0.1039
Echinococcus multilocularis jun protein 0.0083 0.0249 0.0249
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.002 0.002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0166 0.0166
Schistosoma mansoni zinc finger protein 0.0015 0.0014 0.0057
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.002 0.0252
Onchocerca volvulus 0.0017 0.002 0.1039
Onchocerca volvulus 0.0017 0.002 0.1039
Leishmania major cathepsin L-like protease 0.0064 0.0185 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.002 0.002
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0022 0.0276
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.037 0.4796
Echinococcus granulosus intermediate filament protein 0.0027 0.0056 0.0056
Brugia malayi Cytochrome P450 family protein 0.0012 0.0004 0.005
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0185 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0101 0.1301
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0056 0.0716
Onchocerca volvulus 0.0017 0.002 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0012 0.0147
Brugia malayi Muscleblind-like protein 0.0147 0.0472 0.6129
Onchocerca volvulus 0.0017 0.002 0.1039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.002 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Schistosoma mansoni hypothetical protein 0.0167 0.0541 0.2277
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.2375 0.2375
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0863
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0032 0.0408
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 1
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.077 0.077
Onchocerca volvulus 0.0027 0.0056 0.2959
Loa Loa (eye worm) hypothetical protein 0.0025 0.0048 0.0611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 1
Echinococcus multilocularis cysteine protease 0.0017 0.002 0.002
Brugia malayi hypothetical protein 0.0232 0.077 1
Loa Loa (eye worm) fibroinase 0.0017 0.002 0.0252
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0137 0.7348
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Brugia malayi hypothetical protein 0.0016 0.0017 0.0214
Leishmania major hypothetical protein, conserved 0.0025 0.0048 0.2397
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.037 0.4796
Leishmania major cysteine peptidase A (CPA) 0.0017 0.002 0.0863
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 1
Entamoeba histolytica cysteine protease, putative 0.0017 0.002 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Onchocerca volvulus 0.0027 0.0056 0.2959
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.002 0.002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.002 0.0083
Loa Loa (eye worm) hypothetical protein 0.0232 0.077 1
Echinococcus granulosus jun protein 0.0083 0.0249 0.0249
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0004 0.005
Echinococcus multilocularis zinc finger protein 0.0019 0.0028 0.0028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Echinococcus granulosus muscleblind protein 0.0147 0.0472 0.0472
Schistosoma mansoni jun-related protein 0.0067 0.0195 0.082
Onchocerca volvulus 0.0047 0.0126 0.6749
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 1
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0004 0.005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.002 0.0252
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0185 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0007 0.0007
Echinococcus granulosus lamin dm0 0.0027 0.0056 0.0056
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.2884 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0056 0.0716
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0084 0.0084
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0004 0.005
Onchocerca volvulus 0.0017 0.002 0.1039
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0038 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0007 0.0007
Echinococcus granulosus microtubule associated protein 2 0.0694 0.2375 0.2375
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0056 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.0249 0.0249
Trypanosoma cruzi ISWI complex protein 0.0015 0.0014 0.0516
Loa Loa (eye worm) hypothetical protein 0.0027 0.0054 0.0694
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.0252
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.0249 0.0249
Echinococcus multilocularis lamin dm0 0.0027 0.0056 0.0056
Echinococcus granulosus lamin 0.0027 0.0056 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.002 0.0863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Leishmania major cathepsin L-like protease 0.0064 0.0185 1
Echinococcus multilocularis thymidine phosphorylase 0.2884 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0084 0.0084
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0056 0.0716
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0048 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.0252
Brugia malayi Cathepsin L-like precursor 0.0017 0.002 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Schistosoma mansoni hypothetical protein 0.002 0.0032 0.0134
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.002 0.002
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.002 0.0083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 1
Trypanosoma cruzi ISWI complex protein 0.0015 0.0014 0.0516
Schistosoma mansoni zinc finger protein 0.0019 0.0028 0.0119
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.002 0.0084
Loa Loa (eye worm) hypothetical protein 0.0038 0.0093 0.1196
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0048 0.2397
Loa Loa (eye worm) ctsf protein 0.0017 0.002 0.0252
Leishmania major hypothetical protein, conserved 0.0015 0.0014 0.0516
Onchocerca volvulus Cathepsin L homolog 0.0017 0.002 0.1039
Echinococcus multilocularis geminin 0.0167 0.0541 0.0541
Mycobacterium ulcerans thymidine phosphorylase 0.2884 1 1
Echinococcus granulosus cathepsin l1 0.0017 0.002 0.002
Leishmania major cathepsin L-like protease 0.0017 0.002 0.0863
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0185 1
Echinococcus granulosus zinc finger protein 0.0019 0.0028 0.0028
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.2375 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.1386
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0814 0.2795 0.2792
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.002 0.0083
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0185 1
Onchocerca volvulus 0.0065 0.0187 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0185 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0038 0.0038
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.002 0.002
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0814 0.2795 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.002 1
Brugia malayi Bromodomain containing protein 0.0074 0.0218 0.2824
Echinococcus granulosus cathepsin l1 0.0011 0.0001 0.0001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 1
Schistosoma mansoni bromodomain containing protein 0.0062 0.0178 0.0748
Echinococcus granulosus geminin 0.0167 0.0541 0.0541
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0056 0.0716
Loa Loa (eye worm) hypothetical protein 0.008 0.0241 0.312
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0082
Loa Loa (eye worm) hypothetical protein 0.0147 0.0472 0.6129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.002 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.002 1
Schistosoma mansoni lamin 0.0027 0.0056 0.0234

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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