Detailed information for compound 1478093

Basic information

Technical information
  • TDR Targets ID: 1478093
  • Name: ethyl 1-(5-methyl-3-phenyl1,2-oxazole-4-carbo nyl)piperidine-4-carboxylate
  • MW: 342.389 | Formula: C19H22N2O4
  • H donors: 0 H acceptors: 3 LogP: 2.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1CCN(CC1)C(=O)c1c(C)onc1c1ccccc1
  • InChi: 1S/C19H22N2O4/c1-3-24-19(23)15-9-11-21(12-10-15)18(22)16-13(2)25-20-17(16)14-7-5-4-6-8-14/h4-8,15H,3,9-12H2,1-2H3
  • InChiKey: YPQLHSXFEAWIPG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 1-(5-methyl-3-phenyl-isoxazole-4-carbonyl)piperidine-4-carboxylate
  • 1-[(5-methyl-3-phenyl-4-isoxazolyl)-oxomethyl]-4-piperidinecarboxylic acid ethyl ester
  • 1-(5-methyl-3-phenyl-isoxazole-4-carbonyl)isonipecotic acid ethyl ester
  • ethyl 1-[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]piperidine-4-carboxylate
  • Oprea1_771361
  • MLS000712267
  • SMR000282034
  • Oprea1_553440
  • Maybridge3_002198
  • STK018062
  • IDI1_013585
  • ZINC00153496
  • BAS 03589442

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax importin-beta 2, putative 0.0035 0.0125 0.0205
Toxoplasma gondii hypothetical protein 0.0134 0.1148 0.2547
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0607 0.6049 1
Echinococcus multilocularis prolyl endopeptidase 0.042 0.4109 0.4109
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0591 0.5148
Loa Loa (eye worm) hypothetical protein 0.0023 0.0008 0.0008
Brugia malayi Pre-SET motif family protein 0.0026 0.0034 0.0034
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.1148 0.1148
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0458 0.4507 1
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0134 0.1148 1
Echinococcus granulosus acylamino acid releasing enzyme 0.0134 0.1148 0.1148
Loa Loa (eye worm) transcription factor SMAD2 0.0104 0.0841 0.0841
Echinococcus granulosus lamin dm0 0.0023 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0034 0.0034
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0607 0.6049 1
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0227 0.2117 0.3455
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0034 0.0034
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0227 0.2117 0.5
Giardia lamblia Alanyl dipeptidyl peptidase 0.0134 0.1148 1
Loa Loa (eye worm) hypothetical protein 0.0282 0.269 0.269
Trypanosoma brucei prolyl endopeptidase 0.042 0.4109 0.6793
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0607 0.6049 0.6049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0181 0.1642 0.1642
Echinococcus granulosus intermediate filament protein 0.0023 0.0008 0.0008
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0591 0.5148
Trypanosoma cruzi oligopeptidase b 0.0227 0.2117 0.3499
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0057 0.0301
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0125 0.0207
Onchocerca volvulus Prolyl endopeptidase homolog 0.042 0.4109 0.4105
Plasmodium vivax hypothetical protein, conserved 0.0134 0.1148 0.1874
Trichomonas vaginalis set domain proteins, putative 0.0206 0.1901 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0104 0.0841 0.0841
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0614 0.6127 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0125 0.0125
Brugia malayi MH2 domain containing protein 0.0104 0.0841 0.0841
Loa Loa (eye worm) intermediate filament protein 0.0023 0.0008 0.0008
Brugia malayi intermediate filament protein 0.0023 0.0008 0.0008
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0023 0.0008 0.0008
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0125 0.0278
Plasmodium falciparum importin beta, putative 0.0035 0.0125 0.0205
Trypanosoma cruzi hypothetical protein, conserved 0.0134 0.1148 0.1898
Leishmania major importin beta-1 subunit, putative 0.0028 0.0057 0.0095
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0614 0.6127 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0034 0.0034
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0227 0.2117 0.3499
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0607 0.6049 1
Brugia malayi Intermediate filament tail domain containing protein 0.0023 0.0008 0.0008
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0614 0.6127 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0134 0.1148 0.1898
Entamoeba histolytica prolyl oligopeptidase family protein 0.0134 0.1148 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0042 0.02 0.02
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0286 0.2726 0.445
Onchocerca volvulus 0.0026 0.0034 0.0026
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0607 0.6049 0.6049
Schistosoma mansoni hypothetical protein 0.0148 0.1293 0.1293
Loa Loa (eye worm) hypothetical protein 0.0324 0.3124 0.3124
Loa Loa (eye worm) hypothetical protein 0.0134 0.1148 0.1148
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0028 0.0057 0.0498
Mycobacterium tuberculosis Probable peptidase 0.0227 0.2117 0.3455
Plasmodium vivax SET domain protein, putative 0.0026 0.0034 0.0056
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0034 0.0076
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0134 0.1148 0.1148
Brugia malayi prolyl oligopeptidase family protein 0.042 0.4109 0.4109
Echinococcus granulosus geminin 0.0148 0.1293 0.1293
Echinococcus granulosus survival motor neuron protein 1 0.0206 0.1897 0.1897
Schistosoma mansoni importin beta-1 0.0035 0.0125 0.0125
Onchocerca volvulus 0.0206 0.1901 0.1895
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.042 0.4109 0.4109
Loa Loa (eye worm) hypothetical protein 0.0206 0.1897 0.1897
Echinococcus granulosus snurportin 1 0.0372 0.3614 0.3614
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0057 0.0301
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0607 0.6049 1
Schistosoma mansoni hypothetical protein 0.0148 0.1293 0.1293
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0034 0.0034
Trypanosoma brucei prolyl oligopeptidase, putative 0.0227 0.2117 0.3499
Loa Loa (eye worm) hypothetical protein 0.042 0.4109 0.4109
Trichomonas vaginalis conserved hypothetical protein 0.0134 0.1148 0.6039
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0134 0.1148 0.2547
Trypanosoma cruzi prolyl endopeptidase 0.042 0.4109 0.6793
Loa Loa (eye worm) hypothetical protein 0.0035 0.0125 0.0125
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0134 0.1148 0.1148
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0227 0.2117 0.3499
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0057 0.0095
Entamoeba histolytica prolyl oligopeptidase family protein 0.0134 0.1148 1
Loa Loa (eye worm) prolyl oligopeptidase 0.0134 0.1148 0.1148
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0988 1 1
Schistosoma mansoni hypothetical protein 0.0372 0.3614 0.3614
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0227 0.2117 0.3499
Brugia malayi Pre-SET motif family protein 0.0181 0.1642 0.1642
Leishmania major oligopeptidase b 0.0227 0.2117 0.3499
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0614 0.6127 0.5
Echinococcus multilocularis lamin dm0 0.0023 0.0008 0.0008
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0591 0.5148
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0614 0.6127 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.042 0.4109 0.6793
Brugia malayi prolyl oligopeptidase family protein 0.0607 0.6049 0.6049
Schistosoma mansoni hypothetical protein 0.0042 0.02 0.02
Echinococcus multilocularis survival motor neuron protein 1 0.0206 0.1897 0.1897
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0227 0.2117 0.3455
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0614 0.6127 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0125 0.0125
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0057 0.0301
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0134 0.1148 0.6039
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.042 0.4109 0.4109
Brugia malayi RNA, U transporter 1 0.0099 0.079 0.079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0034 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0034 0.0034
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0988 1 1
Echinococcus multilocularis musashi 0.0023 0.0008 0.0008
Schistosoma mansoni lamin 0.0023 0.0008 0.0008
Toxoplasma gondii prolyl endopeptidase 0.042 0.4109 0.9117
Brugia malayi prolyl oligopeptidase family protein 0.0134 0.1148 0.1148
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0607 0.6049 1
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0614 0.6127 1
Giardia lamblia Alanyl dipeptidyl peptidase 0.0134 0.1148 1
Echinococcus granulosus prolyl endopeptidase 0.042 0.4109 0.4109
Brugia malayi hypothetical protein 0.0206 0.1897 0.1897
Trypanosoma brucei oligopeptidase b 0.0227 0.2117 0.3499
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0591 0.5148
Brugia malayi hypothetical protein 0.0324 0.3124 0.3124
Echinococcus multilocularis snurportin 1 0.0372 0.3614 0.3614
Entamoeba histolytica prolyl oligopeptidase family protein 0.0134 0.1148 1
Echinococcus multilocularis acylamino acid releasing enzyme 0.0134 0.1148 0.1148
Schistosoma mansoni intermediate filament proteins 0.0023 0.0008 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0034 0.0034
Echinococcus granulosus Dipeptidyl peptidase 9 0.0607 0.6049 0.6049
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0125 0.0207
Onchocerca volvulus 0.0042 0.02 0.0192
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0614 0.6127 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0988 1 1
Echinococcus multilocularis geminin 0.0148 0.1293 0.1293
Loa Loa (eye worm) prolyl oligopeptidase 0.0988 1 1
Schistosoma mansoni survival motor neuron protein 0.0042 0.02 0.02
Trypanosoma cruzi oligopeptidase b 0.0227 0.2117 0.3499
Echinococcus multilocularis lamin 0.0023 0.0008 0.0008
Entamoeba histolytica hypothetical protein, conserved 0.0134 0.1148 1
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0988 1 1
Plasmodium falciparum peptidase, putative 0.0134 0.1148 0.1874
Trypanosoma cruzi hypothetical protein, conserved 0.0134 0.1148 0.1898
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0134 0.1148 0.6039
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.3614 0.3614
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0227 0.2117 0.3499
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0134 0.1148 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0025 0.0024 0.0024
Echinococcus granulosus lamin 0.0023 0.0008 0.0008
Brugia malayi Importin beta-1 subunit 0.0035 0.0125 0.0125
Entamoeba histolytica fatty acid elongase, putative 0.008 0.0591 0.5148
Schistosoma mansoni lamin 0.0023 0.0008 0.0008

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1122 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.