Detailed information for compound 1482026

Basic information

Technical information
  • TDR Targets ID: 1482026
  • Name: 4-chloro-N-[2-methyl-1-[4-(phenylmethyl)piper azin-1-yl]propan-2-yl]benzenesulfonamide
  • MW: 421.984 | Formula: C21H28ClN3O2S
  • H donors: 1 H acceptors: 2 LogP: 3.48 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)NC(CN1CCN(CC1)Cc1ccccc1)(C)C
  • InChi: 1S/C21H28ClN3O2S/c1-21(2,23-28(26,27)20-10-8-19(22)9-11-20)17-25-14-12-24(13-15-25)16-18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3
  • InChiKey: LNFPVLUKRXBVRI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-N-[1,1-dimethyl-2-[4-(phenylmethyl)piperazin-1-yl]ethyl]benzenesulfonamide
  • 4-chloro-N-[1,1-dimethyl-2-[4-(phenylmethyl)-1-piperazinyl]ethyl]benzenesulfonamide
  • N-[2-[4-(benzyl)piperazin-1-yl]-1,1-dimethyl-ethyl]-4-chloro-benzenesulfonamide
  • MLS000775250
  • SMR000368362
  • T0502-7678

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.4169 0.4167
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0486 0.1067
Schistosoma mansoni protein kinase 0.002 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1335 1
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0299 0.0417
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0064 0.0067
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0299 0.1969
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.0972 0.7188
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0328 0.0325
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Brugia malayi neuropeptide F receptor 0.0049 0.0328 0.0672
Onchocerca volvulus 0.0146 0.1329 0.2893
Echinococcus granulosus dnaJ subfamily B 0.0419 0.4169 0.582
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0046 0.0299 0.1969
Echinococcus multilocularis GPCR, family 3, C terminal 0.0035 0.0179 0.0175
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0184 0.108
Echinococcus granulosus serotonin receptor 0.0049 0.0328 0.0454
Brugia malayi AKH receptor 0.0049 0.0328 0.0672
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0487 0.0719
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0043 0.0266 0.0262
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0438 0.0607
Loa Loa (eye worm) AGC/PKA protein kinase 0.0043 0.0266 0.058
Echinococcus granulosus L aminoadipate semialdehyde 0.0085 0.07 0.0974
Onchocerca volvulus 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.0453 0.453 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2927 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0328 0.0454
Brugia malayi Sugar transporter family protein 0.0208 0.1982 0.4342
Schistosoma mansoni serine/threonine protein kinase 0.0146 0.1329 0.1856
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0328 0.0459
Echinococcus granulosus neuropeptide FF receptor 2 0.0049 0.0328 0.0454
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0026 0.005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0468 0.0465
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.012 0.0167
Brugia malayi hypothetical protein 0.0029 0.012 0.0209
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus multilocularis glutamate receptor 2 0.002 0.0026 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0328 0.0459
Schistosoma mansoni hypothetical protein 0.0049 0.0328 0.0459
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0328 0.0325
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Trypanosoma cruzi hexose transporter, putative 0.0029 0.012 0.0994
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0278 0.0384
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0443 0.442 0.9757
Brugia malayi G-protein coupled receptor 0.0049 0.0328 0.0672
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0487 0.0472
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Echinococcus granulosus alpha 1A adrenergic receptor 0.0049 0.0328 0.0454
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0217 0.0347
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus granulosus metabotropic glutamate receptor 5 0.0265 0.2571 0.3587
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0328 0.0459
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0043 0.0266 0.0343
Echinococcus granulosus peptide allatostatin:somatostatin 0.0049 0.0328 0.0454
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0062 0.0465 0.0462
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0181 0.0248
Onchocerca volvulus 0.0029 0.012 0.0209
Schistosoma mansoni tar DNA-binding protein 0.0062 0.046 0.0643
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0049 0.0328 0.0718
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0328 0.0325
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.0026 0.0022
Schistosoma mansoni amine GPCR 0.0049 0.0328 0.0459
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0487 0.4874
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0049 0.0328 0.0718
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0039 0.0217 0.0298
Brugia malayi putative neuropeptide receptor 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus multilocularis lysyl tRNA synthetase 0.0046 0.0299 0.0295
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0972 0.2141
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.005
Schistosoma mansoni metabotropic glutamate receptor 0.0105 0.0907 0.1266
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0309 0.2992
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0217 0.1203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0217 0.2022
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0972 0.3037
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0972 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0309 0.0976
Brugia malayi Sugar transporter family protein 0.0029 0.012 0.0209
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0092 0.0311
Onchocerca volvulus 0.0029 0.0121 0.0211
Schistosoma mansoni opsin-like receptor 0.0049 0.0328 0.0459
Trypanosoma cruzi hexose transporter 0.0065 0.0487 0.4874
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0035 0.007
Schistosoma mansoni hypothetical protein 0.004 0.023 0.0321
Echinococcus granulosus dro:myosuppressin receptor 0.0049 0.0328 0.0454
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0064 0.015
Echinococcus granulosus tyrosine kinase 0.002 0.0026 0.0031
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0972 0.3263
Toxoplasma gondii lysine-tRNA ligase 0.0046 0.0299 0.0399
Echinococcus multilocularis receptor type guanylyl cyclase 0.002 0.0026 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0328 0.0325
Plasmodium falciparum mitogen-activated protein kinase 2 0.0337 0.3324 0.364
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0399
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.2927 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0328 0.0454
Loa Loa (eye worm) hypothetical protein 0.0045 0.0287 0.0626
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0833 0.1163
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0148 0.0142
Onchocerca volvulus 0.0085 0.07 0.1497
Onchocerca volvulus 0.0049 0.0328 0.0672
Echinococcus multilocularis neuropeptide receptor A26 0.0049 0.0328 0.0325
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Schistosoma mansoni tar DNA-binding protein 0.0062 0.046 0.0643
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0128 0.3268
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0049 0.0328 0.0459
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0487 0.0719
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0573 0.578
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.1982 0.1979
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0281 0.0388
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Trypanosoma brucei glucose transporter, putative 0.0065 0.0487 0.4657
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0128 0.0028
Schistosoma mansoni glucose transport protein 0.0208 0.1982 0.2767
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0817 0.0814
Onchocerca volvulus Neuropeptide F receptor homolog 0.0049 0.0328 0.0672
Brugia malayi hypothetical protein 0.0029 0.012 0.0209
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0309 0.0629
Loa Loa (eye worm) hypothetical protein 0.0041 0.0245 0.0535
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0256 0.0352
Loa Loa (eye worm) hypothetical protein 0.0039 0.0217 0.0472
Brugia malayi Serotonin receptor 0.0049 0.0328 0.0672
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0328 0.0454
Echinococcus multilocularis g-protein coupled receptor 0.0049 0.0328 0.0325
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0328 0.0325
Schistosoma mansoni tar DNA-binding protein 0.0062 0.046 0.0643
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0573 0.5602
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0049 0.0328 0.0325
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0328 0.0459
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0328 0.0454
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0082 0.0174
Onchocerca volvulus 0.0049 0.0328 0.0672
Echinococcus granulosus neuropeptide receptor A26 0.0049 0.0328 0.0454
Echinococcus multilocularis serotonin receptor 0.0049 0.0328 0.0325
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0217 0.0214
Schistosoma mansoni opsin-like receptor 0.0049 0.0328 0.0459
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0043 0.0266 0.2535
Echinococcus multilocularis somatostatin receptor 0.0049 0.0328 0.0325
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0062 0.0465 0.3156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0281 0.0392
Leishmania major protein kinase, putative 0.0065 0.0486 0.4866
Loa Loa (eye worm) hypothetical protein 0.0085 0.07 0.154
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0328 0.0325
Schistosoma mansoni hypothetical protein 0.0035 0.0181 0.0253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0328 0.0459
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Brugia malayi GnHR receptor homolog 0.0049 0.0328 0.0672
Loa Loa (eye worm) AGC/PKA protein kinase 0.0043 0.0266 0.058
Onchocerca volvulus 0.0029 0.012 0.0209
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.005
Echinococcus multilocularis General substrate transporter 0.0179 0.1677 0.1674
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0487 0.4657
Toxoplasma gondii sugar transporter ST3 0.0029 0.012 0.0095
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0972 0.3263
Echinococcus multilocularis G protein coupled receptor 139 0.0049 0.0328 0.0325
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0128 0.0352
Brugia malayi G-protein coupled receptor 0.0049 0.0328 0.0672
Brugia malayi Cam kinase protein 1 0.0065 0.0486 0.1023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0328 0.0459
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0487 0.1309
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0487 0.4657
Echinococcus multilocularis tar DNA binding protein 0.0062 0.046 0.0457
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0164 0.0785
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0309 0.1926
Loa Loa (eye worm) runx1 0.0057 0.0407 0.0891
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.0972 0.3219
Giardia lamblia PHD finger protein 15 0.0032 0.0148 0.01
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0043 0.0266 0.2535
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0128 0.0028
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0278 0.0275
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0299 0.0638
Schistosoma mansoni amine GPCR 0.0049 0.0328 0.0459
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Brugia malayi Sugar transporter family protein 0.0029 0.012 0.0209
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.1982 0.2764
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0309 0.2047
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0043 0.0266 0.0262
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0043 0.0266 0.0533
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0049 0.0328 0.0672
Brugia malayi ORL1-like opioid receptor 0.0049 0.0328 0.0672
Brugia malayi major facilitator superfamily protein 0.0029 0.012 0.0209
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0184 0.5485
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0309 0.2992
Brugia malayi G protein-coupled receptor 0.0049 0.0328 0.0672
Echinococcus granulosus tachykinin peptides receptor 99D 0.0049 0.0328 0.0454
Schistosoma mansoni hypothetical protein 0.0049 0.0328 0.0459
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0328 0.0718
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0043 0.0266 0.0366
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0004 0.0005
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.0573 0.578
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0085 0.07 0.0978
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0573 0.578
Schistosoma mansoni sugar transporter 0.0029 0.012 0.0167
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0905 0.1259
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0128 0.0028
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0486 0.1023
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0817 0.2729
Onchocerca volvulus 0.0029 0.012 0.0209
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0164 0.0785
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0309 0.2047
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.002 0.0026 0.0022
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0245 0.0338
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0972 0.1358
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0328 0.0459
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0043 0.0266 0.0366
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0049 0.0328 0.0718
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0184 0.0134
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0181 0.0345
Echinococcus multilocularis solute carrier family 22 0.0029 0.012 0.0116
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0245 0.0535
Onchocerca volvulus 0.0049 0.0328 0.0672
Echinococcus granulosus g-protein coupled receptor 0.0049 0.0328 0.0454
Loa Loa (eye worm) hypothetical protein 0.0125 0.1119 0.2465
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.012 0.0209
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0184 0.0134
Giardia lamblia Kinase, AGC PKA 0.0043 0.0266 0.052
Plasmodium falciparum lysine--tRNA ligase 0.0046 0.0299 0.0262
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0183 0.1656
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0328 0.0718
Onchocerca volvulus Poor gastrulation protein homolog 0.0035 0.0179 0.0339
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.0972 0.7146
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.012 0.0095
Echinococcus granulosus sex peptide receptor 0.0049 0.0328 0.0454
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0217 0.0214
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Echinococcus granulosus GPCR family 2 0.0035 0.0181 0.0248
Schistosoma mansoni amine GPCR 0.0049 0.0328 0.0459
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0487 0.0472
Mycobacterium ulcerans hypothetical protein 0.0047 0.0309 0.2047
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0281 0.0388
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0486 0.0483
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0266 0.0371
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0128 0.0028
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0073 0.0102
Loa Loa (eye worm) hypothetical protein 0.0453 0.453 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.0026 0.0031
Brugia malayi hypothetical protein 0.0029 0.012 0.0209
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.7161 0.716
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0328 0.0325
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0111 0.0972 0.2101
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0128 0.0028
Entamoeba histolytica protein kinase, putative 0.0065 0.0486 0.1588
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0309 0.0629
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0328 0.0325
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0328 0.0325
Echinococcus granulosus tar DNA binding protein 0.0062 0.046 0.0638
Toxoplasma gondii AGC kinase 0.0043 0.0266 0.0343
Brugia malayi lysyl-tRNA synthetase 0.0046 0.0299 0.0606
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0049 0.0328 0.0325
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Plasmodium falciparum proline--tRNA ligase 0.0073 0.0573 0.0568
Onchocerca volvulus 0.0029 0.012 0.0209
Echinococcus multilocularis orexin receptor type 2 0.0049 0.0328 0.0325
Echinococcus multilocularis allatostatin A receptor 0.0049 0.0328 0.0325
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.046 0.1009
Onchocerca volvulus 0.0049 0.0328 0.0672
Schistosoma mansoni DNA polymerase eta 0.0039 0.0217 0.0303
Loa Loa (eye worm) hypothetical protein 0.0043 0.0266 0.058
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0049 0.0328 0.0454
Schistosoma mansoni glutamate receptor NMDA 0.002 0.0026 0.0036
Loa Loa (eye worm) hypothetical protein 0.0265 0.2571 0.5673
Schistosoma mansoni biogenic amine receptor 0.0049 0.0328 0.0459
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0486 0.0675
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0148 0.0207
Onchocerca volvulus 0.0029 0.012 0.0209
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0486 0.4649
Echinococcus granulosus General substrate transporter 0.0179 0.1677 0.2338
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0035 0.0179 0.0339
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0208 0.1982 0.1979
Leishmania major protein kinase A catalytic subunit 0.0043 0.0266 0.2535
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Echinococcus multilocularis L aminoadipate semialdehyde 0.0085 0.07 0.0697
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.005
Schistosoma mansoni hypothetical protein 0.0049 0.0328 0.0459
Brugia malayi Tachykinin-like peptides receptor 99D 0.0049 0.0328 0.0672
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0328 0.0454
Schistosoma mansoni neuropeptide receptor 0.0049 0.0328 0.0459
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0328 0.0454
Schistosoma mansoni hypothetical protein 0.0035 0.0181 0.0253
Echinococcus granulosus solute carrier family 22 0.0029 0.012 0.0163
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.0972 0.7146
Echinococcus multilocularis GPCR, family 2 0.0035 0.0181 0.0178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0281 0.0392
Loa Loa (eye worm) G-protein coupled receptor 0.0049 0.0328 0.0718
Brugia malayi CHE-14 protein 0.0041 0.0245 0.0487
Echinococcus multilocularis dna polymerase eta 0.0039 0.0217 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus granulosus microtubule associated protein 2 0.0706 0.7161 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0465 0.065
Plasmodium vivax lysine--tRNA ligase, putative 0.0046 0.0299 0.0262
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.005
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.012 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.1982 0.6634
Loa Loa (eye worm) hypothetical protein 0.0072 0.0568 0.1248
Echinococcus multilocularis protein patched 0.0041 0.0245 0.0242
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0046 0.0299 0.2584
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0049 0.0328 0.0325
Trypanosoma brucei unspecified product 0.0027 0.0092 0.0311
Loa Loa (eye worm) hypothetical protein 0.0125 0.1119 0.2465
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0328 0.0325
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.012 0.0163
Trypanosoma brucei glucose transporter, putative 0.0065 0.0487 0.4657
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0309 0.2047
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0055 0.0389 0.0852
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0309 0.2047
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0046 0.0299 0.2885
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0128 0.0028
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0486 0.0483
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Schistosoma mansoni hypothetical protein 0.0419 0.4169 0.5822
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0245 0.0338
Onchocerca volvulus 0.0049 0.0328 0.0672
Echinococcus granulosus orexin receptor type 2 0.0049 0.0328 0.0454
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0217 0.1203
Schistosoma mansoni cpg binding protein 0.0033 0.0159 0.0222
Loa Loa (eye worm) phosphofructokinase 0.0111 0.0972 0.2141
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.012 0.0994
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0128 0.0288
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0328 0.0459
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0049 0.0328 0.0459
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0487 0.0472
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0198 0.0194
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0128 0.0071
Onchocerca volvulus 0.0029 0.012 0.0209
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0487 0.0719
Echinococcus granulosus neuropeptide receptor 0.0049 0.0328 0.0454
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0073 0.0097
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0328 0.0459
Brugia malayi RNA binding protein 0.0062 0.046 0.0964
Echinococcus granulosus zinc finger protein 0.0022 0.0041 0.0053
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0062 0.0465 0.123
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0076 0.0606 0.1331
Loa Loa (eye worm) sugar transporter 0.0029 0.012 0.0258
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.0042 0.0249 0.0543
Trypanosoma brucei sugar transporter, putative 0.0029 0.012 0.0613
Onchocerca volvulus 0.0049 0.0328 0.0672
Brugia malayi sulfakinin receptor protein 0.0049 0.0328 0.0672
Echinococcus multilocularis neuropeptide receptor 0.0049 0.0328 0.0325
Echinococcus granulosus dna polymerase eta 0.0039 0.0217 0.0299
Onchocerca volvulus 0.0049 0.0328 0.0672
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0328 0.0325
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Onchocerca volvulus 0.0029 0.012 0.0209
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.2927 1
Trichomonas vaginalis AGC family protein kinase 0.0043 0.0266 0.052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0468 0.0649
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0328 0.0459
Plasmodium falciparum protein kinase 6 0.0885 0.9018 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0049 0.0328 0.0454
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0486 0.0483
Onchocerca volvulus 0.0029 0.012 0.0209
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0049 0.0328 0.0325
Brugia malayi Protein kinase domain containing protein 0.0443 0.442 0.9756
Schistosoma mansoni amine GPCR 0.0049 0.0328 0.0459
Echinococcus multilocularis Protein lozenge 0.0057 0.0407 0.0403
Trypanosoma brucei glucose transporter, putative 0.0065 0.0487 0.4657
Echinococcus granulosus atrial natriuretic peptide receptor 0.002 0.0026 0.0031
Loa Loa (eye worm) hypothetical protein 0.0062 0.0465 0.102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0328 0.0459
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0256 0.0357
Echinococcus multilocularis rho associated protein kinase 0.0146 0.1329 0.1326
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0217 0.1684
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0164 0.0785
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0328 0.0459
Schistosoma mansoni biogenic amine receptor 0.0049 0.0328 0.0459
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0502 0.1102
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0049 0.0328 0.0672
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0128 0.0108
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.042 0.0605
Trypanosoma brucei glucose transporter, putative 0.0065 0.0487 0.4657
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0487 0.0472
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0064 0.015
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0245 0.0242
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0487 0.0472
Trypanosoma brucei glucose transporter, putative 0.0065 0.0487 0.4657
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.1982 0.2764
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Schistosoma mansoni tyrosine kinase 0.002 0.0026 0.0036
Brugia malayi CXXC zinc finger family protein 0.0029 0.0121 0.0211
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Schistosoma mansoni alpha-1 adrenergic receptor 0.0049 0.0328 0.0459
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0064 0.0761
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Entamoeba histolytica PH domain containing protein kinase, putative 0.0043 0.0266 0.0827
Brugia malayi Dopamine receptor protein 2 0.0049 0.0328 0.0672
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0217 0.2022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0464 0.0648
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0184 0.0944
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0487 0.4874
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0217 0.2022
Trypanosoma brucei glucose transporter 2A 0.0065 0.0487 0.4657
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0039 0.0217 0.0213
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0049 0.0328 0.0325
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0328 0.0454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0281 0.0392
Leishmania major glucose transporter, lmgt3 0.0065 0.0487 0.4874
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0972 0.3037
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0043 0.0266 0.2219
Onchocerca volvulus Alhambra homolog 0.0032 0.0148 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Echinococcus granulosus peregrin 0.0034 0.0173 0.0237
Brugia malayi 6-phosphofructokinase 0.0111 0.0972 0.2101
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0062 0.0465 0.1515
Echinococcus multilocularis solute carrier family 22 0.0029 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0281 0.0277
Echinococcus multilocularis cpg binding protein 0.0033 0.0159 0.0155
Echinococcus granulosus 7tm_1 domain containing protein 0.0049 0.0328 0.0454
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0049 0.0328 0.0672
Onchocerca volvulus 0.0047 0.0309 0.0629
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0438 0.0434
Onchocerca volvulus 0.0141 0.128 0.2784
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0486 0.1306
Echinococcus granulosus solute carrier family 22 0.0029 0.012 0.0163
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0049 0.0328 0.0459
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.0573 0.0865
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Trypanosoma brucei glucose transporter, putative 0.0065 0.0487 0.4657
Onchocerca volvulus Huntingtin homolog 0.0125 0.1119 0.2428
Schistosoma mansoni myosin xvIII 0.0049 0.0328 0.0459
Schistosoma mansoni hypothetical protein 0.0049 0.0328 0.0459
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0043 0.0266 0.2535
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0309 0.2047
Onchocerca volvulus Huntingtin homolog 0.0125 0.1119 0.2428
Echinococcus multilocularis protein dispatched 1 0.0047 0.0306 0.0303
Loa Loa (eye worm) TAR-binding protein 0.0062 0.046 0.1009
Echinococcus multilocularis zinc finger protein 0.0022 0.0041 0.0038
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0073 0.0069
Brugia malayi Receptor family ligand binding region containing protein 0.0055 0.0389 0.0807
Schistosoma mansoni hypothetical protein 0.0021 0.0035 0.0049
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0487 0.0472
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0181 0.0393
Echinococcus multilocularis nmda type glutamate receptor 0.002 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus granulosus cpg binding protein 0.0033 0.0159 0.0217
Echinococcus granulosus G protein coupled receptor 139 0.0049 0.0328 0.0454
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0486 0.0675
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.012 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0328 0.0325
Loa Loa (eye worm) glutamate receptor 0.0215 0.2054 0.453
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.012 0.0116
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Loa Loa (eye worm) hypothetical protein 0.0062 0.0465 0.102
Echinococcus granulosus glutamate receptor 2 0.002 0.0026 0.0031
Plasmodium falciparum hexose transporter 0.0208 0.1982 0.2142
Brugia malayi PHD-finger family protein 0.0032 0.0148 0.0271
Onchocerca volvulus 0.0453 0.453 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0885 0.9018 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.1982 0.2764
Schistosoma mansoni adenoreceptor 0.0049 0.0328 0.0459
Plasmodium vivax hexose transporter 0.0208 0.1982 0.2142
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0245 0.0447
Loa Loa (eye worm) hypothetical protein 0.0035 0.0179 0.0387
Giardia lamblia DINP protein human, muc B family 0.0039 0.0217 0.0347
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1335 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0905 0.0902
Echinococcus granulosus neuropeptide s receptor 0.0049 0.0328 0.0454
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0128 0.0071
Entamoeba histolytica hypothetical protein 0.0046 0.0299 0.0941
Brugia malayi hypothetical protein 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.005
Schistosoma mansoni sugar transporter 0.0029 0.012 0.0167
Schistosoma mansoni bromodomain containing protein 0.0066 0.0506 0.0707
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0265 0.2571 0.2569
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0487 0.1309
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Brugia malayi Dopamine receptor 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.0055 0.0389 0.0852
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2927 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.1248 0.1244
Loa Loa (eye worm) hypothetical protein 0.0111 0.0972 0.214
Leishmania major protein kinase A catalytic subunit isoform 1 0.0043 0.0266 0.2535
Onchocerca volvulus 0.0049 0.0328 0.0672
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0217 0.1335
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0972 0.1358
Schistosoma mansoni hypothetical protein 0.0032 0.0148 0.0207
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.012 0.0209
Brugia malayi Bromodomain containing protein 0.0039 0.0223 0.0438
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0972 0.3037
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0043 0.0266 0.2219
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0181 0.0178
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0266 0.0371
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0049 0.0328 0.0672
Echinococcus multilocularis expressed conserved protein 0.0091 0.0757 0.0753
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.2927 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1335 1
Trypanosoma brucei unspecified product 0.0027 0.0092 0.0311
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0049 0.0328 0.0325
Brugia malayi Dopamine receptor protein 1 0.0049 0.0328 0.0672
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0181 0.0178
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0218 0.0215
Echinococcus granulosus g protein coupled receptor 0.0049 0.0328 0.0454
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Echinococcus granulosus receptor type guanylyl cyclase 0.002 0.0026 0.0031
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0217 0.0303
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0208 0.1982 0.2764
Plasmodium falciparum protein kinase 7 0.0589 0.5944 0.6567
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0217 0.0303
Entamoeba histolytica hypothetical protein 0.0024 0.0064 0.0132
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0217 0.066
Onchocerca volvulus 0.0049 0.0328 0.0672
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0049 0.0328 0.0459
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0309 0.0629
Loa Loa (eye worm) hypothetical protein 0.0032 0.0148 0.0319
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Onchocerca volvulus 0.0049 0.0328 0.0672
Schistosoma mansoni hypothetical protein 0.004 0.023 0.0321
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0043 0.0266 0.0225
Echinococcus multilocularis sex peptide receptor 0.0049 0.0328 0.0325
Echinococcus multilocularis G-protein coupled receptor, putative 0.0049 0.0328 0.0325
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Schistosoma mansoni tyrosine kinase 0.002 0.0026 0.0036
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0085 0.07 0.1497
Schistosoma mansoni hypothetical protein 0.0208 0.1982 0.2767
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0486 0.0679
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.012 0.0613
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0399
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0487 0.4874
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0328 0.0325
Loa Loa (eye worm) hypothetical protein 0.0051 0.0343 0.0751
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0049 0.0328 0.0459
Schistosoma mansoni sugar transporter 0.0029 0.012 0.0167
Schistosoma mansoni neuropeptide F-like receptor 0.0049 0.0328 0.0459
Echinococcus multilocularis serotonin receptor 0.0049 0.0328 0.0325
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0486 0.0483
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0486 0.0675
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Brugia malayi phosphofructokinase 0.0111 0.0972 0.2101
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0062 0.0465 0.0976
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2927 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0217 0.0425
Schistosoma mansoni glucose transport protein 0.0208 0.1982 0.2767
Onchocerca volvulus 0.0029 0.012 0.0209
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0181 0.0345
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0195 0.1844 0.4035
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0487 0.4874
Schistosoma mansoni lozenge 0.0057 0.0407 0.0568
Brugia malayi G protein-coupled receptor F59B2.13 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0328 0.0454
Onchocerca volvulus 0.0029 0.012 0.0209
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0049 0.0328 0.0459
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0309 0.0976
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0281 0.0277
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0217 0.1684
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0049 0.0328 0.0325
Leishmania major glucose transporter, lmgt2 0.0065 0.0487 0.4874
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0328 0.0454
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0328 0.0325
Loa Loa (eye worm) sugar transporter 0.0208 0.1982 0.437
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0181 0.0248
Onchocerca volvulus 0.0029 0.012 0.0209
Brugia malayi PHD-finger family protein 0.0027 0.0098 0.016
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0026 0.005
Schistosoma mansoni neuropeptide receptor 0.0049 0.0328 0.0459
Echinococcus granulosus somatostatin receptor 0.0049 0.0328 0.0454
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0309 0.2047
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0606 0.1288
Echinococcus granulosus nmda type glutamate receptor 0.002 0.0026 0.0031
Loa Loa (eye worm) melatonin receptor type 1A 0.0049 0.0328 0.0718
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0681 0.0951
Echinococcus multilocularis peregrin 0.0034 0.0173 0.017
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.012 0.0116
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.012 1
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0043 0.0266 0.0262
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0245 0.2361 0.3297
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0328 0.0454
Onchocerca volvulus 0.0049 0.0328 0.0672
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0487 0.1309
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.1982 0.1979
Loa Loa (eye worm) hypothetical protein 0.0055 0.0386 0.0844
Trypanosoma cruzi sugar transporter, putative 0.0029 0.012 0.0994
Echinococcus granulosus expressed conserved protein 0.0091 0.0757 0.1052
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.1248 0.1738
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.012 0.0438
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0328 0.0454
Schistosoma mansoni protein kinase 0.0065 0.0486 0.0679
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0328 0.0459
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0487 0.1309
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0266 0.0371
Schistosoma mansoni hypothetical protein 0.0035 0.0181 0.0253
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0337 0.3324 0.5544
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.012 0.0582
Echinococcus granulosus 7TM GPCR rhodopsin 0.0049 0.0328 0.0454
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.0972 0.0969
Brugia malayi major facilitator superfamily protein 0.0029 0.012 0.0209
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0328 0.0325
Schistosoma mansoni neuropeptide receptor 0.0049 0.0328 0.0459
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0064 0.0406
Echinococcus granulosus rho-associated protein kinase 1 0.0146 0.1329 0.1852
Echinococcus multilocularis neuropeptide Y receptor 0.0049 0.0328 0.0325
Schistosoma mansoni protein kinase 0.0065 0.0486 0.0679
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus granulosus neuropeptide Y receptor 0.0049 0.0328 0.0454
Trypanosoma brucei glucose transporter, putative 0.0065 0.0487 0.4657
Loa Loa (eye worm) hypothetical protein 0.0047 0.0309 0.0675
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0062 0.0465 0.065
Brugia malayi jmjC domain containing protein 0.0042 0.0256 0.051
Echinococcus multilocularis glutamate receptor 2 0.002 0.0026 0.0022
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0309 0.1926
Trypanosoma brucei glucose transporter 1E 0.0065 0.0487 0.4657
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.0972 1
Echinococcus granulosus hypothetical protein 0.0049 0.0328 0.0454
Schistosoma mansoni zinc finger protein 0.0022 0.0041 0.0057
Trypanosoma cruzi glucose transporter, putative 0.0029 0.012 0.0994
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Leishmania major lysyl-tRNA synthetase, putative 0.0046 0.0299 0.2885
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0256 0.0557
Echinococcus multilocularis fmrfamide receptor 0.0049 0.0328 0.0325
Schistosoma mansoni hypothetical protein 0.004 0.023 0.0321
Echinococcus multilocularis neuropeptide s receptor 0.0049 0.0328 0.0325
Onchocerca volvulus 0.0029 0.012 0.0209
Echinococcus granulosus neuropeptides capa receptor 0.0049 0.0328 0.0454
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0217 0.2022
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0049 0.0328 0.0459
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.012 0.0582
Onchocerca volvulus 0.0049 0.0328 0.0672
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0148 0.0202
Brugia malayi TAR-binding protein 0.0062 0.046 0.0964
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0148 0.0144
Onchocerca volvulus 0.0029 0.012 0.0209
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0217 0.2022
Schistosoma mansoni growth hormone secretagogue receptor 0.0049 0.0328 0.0459
Brugia malayi RE15519p 0.0049 0.0328 0.0672
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0309 0.2992
Leishmania major glucose transporter, lmgt1 0.0065 0.0487 0.4874
Onchocerca volvulus Putative transporter 0.0029 0.012 0.0209
Brugia malayi metabotropic glutamate receptor type 2 0.0105 0.0907 0.1955
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0049 0.0328 0.0459
Echinococcus multilocularis neuropeptides capa receptor 0.0049 0.0328 0.0325
Echinococcus granulosus solute carrier family 22 0.0029 0.012 0.0163
Echinococcus multilocularis tyrosine kinase 0.002 0.0026 0.0022
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0128 0.3268
Trypanosoma brucei glucose transporter, putative 0.0065 0.0487 0.4657
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0328 0.0454
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0226 0.1273
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0281 0.0566
Trypanosoma brucei unspecified product 0.0039 0.0217 0.1684
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0092 0.0311
Schistosoma mansoni amine GPCR 0.0049 0.0328 0.0459
Schistosoma mansoni lysyl-tRNA synthetase 0.0046 0.0299 0.0417
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.005
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0049 0.0328 0.0325
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0148 0.0142
Loa Loa (eye worm) RGC/RGC protein kinase 0.002 0.0026 0.005
Leishmania major DNA polymerase eta, putative 0.0039 0.0217 0.2022
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0217 0.0347
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0164 0.0785
Echinococcus granulosus fmrfamide receptor 0.0049 0.0328 0.0454
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.012 0.0438
Schistosoma mansoni hypothetical protein 0.0035 0.0179 0.025
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.7161 1
Mycobacterium ulcerans sugar transporter 0.0029 0.012 0.0582
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0035 0.0179 0.0339
Schistosoma mansoni cpg binding protein 0.0033 0.0159 0.0222
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0309 0.1926
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0043 0.0266 0.2535
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0208 0.1982 0.1979
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0049 0.0328 0.0459
Echinococcus granulosus GPCR family 3 C terminal 0.0035 0.0179 0.0245
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0049 0.0328 0.0454
Brugia malayi neuropeptide F receptor 0.0049 0.0328 0.0672
Schistosoma mansoni protein kinase 0.0065 0.0486 0.0679
Loa Loa (eye worm) hypothetical protein 0.0047 0.0309 0.0675
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0487 0.1309
Schistosoma mansoni sugar transporter 0.0029 0.012 0.0167
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2927 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.0026 0.0022
Leishmania major protein kinase A catalytic subunit isoform 2 0.0043 0.0266 0.2535
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0486 0.0675
Chlamydia trachomatis lysine--tRNA ligase 0.0046 0.0299 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2927 1
Brugia malayi hypothetical protein 0.0125 0.1119 0.2428
Echinococcus multilocularis solute carrier family 22 0.0029 0.012 0.0116
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.012 0.0209
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0217 0.1684
Echinococcus granulosus glutamate receptor 2 0.002 0.0026 0.0031
Onchocerca volvulus 0.0049 0.0328 0.0672
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0487 0.0472
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.2927 1
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0128 0.0108
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0049 0.0328 0.0718
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.046 0.0964
Onchocerca volvulus 0.0029 0.012 0.0209
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0049 0.0328 0.0454
Loa Loa (eye worm) hypothetical protein 0.0065 0.0486 0.1067
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0217 0.0299
Toxoplasma gondii AGC kinase 0.0043 0.0266 0.0343
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0148 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0049 0.0328 0.0672
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0121 0.026
Loa Loa (eye worm) glutamate receptor 0.0085 0.0696 0.153
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.0972 0.1354
Onchocerca volvulus 0.0049 0.0328 0.0672
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0239 0.0425
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0128 0.0028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0299 0.0653
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.012 0.0163
Echinococcus multilocularis g protein coupled receptor 0.0049 0.0328 0.0325
Schistosoma mansoni tar DNA-binding protein 0.0062 0.046 0.0643
Onchocerca volvulus 0.0029 0.012 0.0209
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0309 0.1926
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Brugia malayi Metabotropic glutamate receptor precursor. 0.0215 0.2054 0.4503
Echinococcus granulosus g protein coupled receptor 0.0049 0.0328 0.0454
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0328 0.0325
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0309 0.2047
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0128 0.0028
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.0573 0.578
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Echinococcus multilocularis neuropeptide FF receptor 2 0.0049 0.0328 0.0325
Schistosoma mansoni hypothetical protein 0.0076 0.0606 0.0846
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.012 0.0582
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.002 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0062 0.0465 0.0976
Echinococcus granulosus dna polymerase kappa 0.0039 0.0217 0.0299
Leishmania major DNA polymerase kappa, putative 0.0039 0.0217 0.2022
Echinococcus granulosus rhodopsin orphan GPCR 0.0049 0.0328 0.0454
Brugia malayi follicle stimulating hormone receptor 0.0049 0.0328 0.0672
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0337 0.3324 0.364
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0328 0.0454
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.002 0.0026 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0487 0.1309
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0111 0.0972 0.214
Toxoplasma gondii facilitative glucose transporter GT1 0.0208 0.1982 0.3261
Schistosoma mansoni patched 1 0.0041 0.0245 0.0343
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0043 0.0266 0.0366
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0046 0.0299 0.1846
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.005
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Brugia malayi Bromodomain containing protein 0.0034 0.0173 0.0327
Onchocerca volvulus 0.0029 0.012 0.0209
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0972 0.3263
Schistosoma mansoni hypothetical protein 0.004 0.023 0.0321
Echinococcus granulosus solute carrier family 22 0.0029 0.012 0.0163
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0972 0.3037
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0043 0.0266 0.2219
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Schistosoma mansoni neuropeptide f receptor 76f 0.0049 0.0328 0.0459
Echinococcus multilocularis dro:myosuppressin receptor 0.0049 0.0328 0.0325
Schistosoma mansoni metabotropic glutamate receptor 0.018 0.1691 0.2361
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0038 0.0027
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0487 0.0472
Loa Loa (eye worm) hypothetical protein 0.0029 0.012 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0049 0.0328 0.0325
Echinococcus granulosus allatostatin A receptor 0.0049 0.0328 0.0454
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Schistosoma mansoni neuropeptide receptor 0.0049 0.0328 0.0459
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0399
Toxoplasma gondii protein kinase, putative 0.0589 0.5944 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.046 0.1009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0309 0.0976
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0486 0.1067
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0039 0.0226 0.1273
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0487 0.4657
Brugia malayi putative neuropeptide receptor NPR1 0.0049 0.0328 0.0672
Toxoplasma gondii sugar transporter ST1 0.0029 0.012 0.0095
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.002 0.0026 0.0031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0049 0.0328 0.0718
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Echinococcus granulosus g protein coupled receptor 0.0049 0.0328 0.0454
Plasmodium vivax sugar transporter, putative 0.0029 0.012 0.0062
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0128 0.0071
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0128 0.0108
Brugia malayi jmjC domain containing protein 0.0105 0.0905 0.1951
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0281 0.0613
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.002 0.0026 0.0031
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0043 0.0266 0.0262
Schistosoma mansoni opsin-like receptor 0.0049 0.0328 0.0459
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0217 0.1684
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0049 0.0328 0.0325
Giardia lamblia Prolyl-tRNA synthetase 0.0062 0.0465 0.123
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0148 0.0319
Loa Loa (eye worm) hypothetical protein 0.0035 0.0181 0.0393
Onchocerca volvulus 0.0049 0.0328 0.0672
Schistosoma mansoni hypothetical protein 0.0035 0.0181 0.0253
Brugia malayi hypothetical protein 0.0453 0.453 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0399
Echinococcus multilocularis metabotropic glutamate receptor 2 0.018 0.1691 0.1688
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0217 0.1335
Echinococcus granulosus neuropeptide receptor 0.0049 0.0328 0.0454
Schistosoma mansoni tar DNA-binding protein 0.0062 0.046 0.0643
Schistosoma mansoni cpg binding protein 0.0029 0.0121 0.0169
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0062 0.0465 0.0645
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2927 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0049 0.0328 0.0459
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0055 0.0389 0.0852
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0039 0.0226 0.1273
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0049 0.0328 0.0459
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0487 0.0472
Giardia lamblia Lysyl-tRNA synthetase 0.0046 0.0299 0.0638
Brugia malayi larval opioid receptor 0.0049 0.0328 0.0672
Brugia malayi Bromodomain containing protein 0.0078 0.0631 0.1344
Brugia malayi Serotonin receptor 0.0049 0.0328 0.0672
Leishmania major hypothetical protein, conserved 0.0029 0.012 0.0994
Loa Loa (eye worm) hypothetical protein 0.0047 0.0309 0.0675
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0817 0.1137
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0972 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0184 0.0399
Loa Loa (eye worm) TYRA-2 protein 0.0049 0.0328 0.0718
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0049 0.0328 0.0325
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0092 0.0311
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0217 0.2022
Loa Loa (eye worm) neuropeptide F receptor 0.0049 0.0328 0.0718
Loa Loa (eye worm) hypothetical protein 0.0049 0.0328 0.0718
Schistosoma mansoni biogenic amine receptor 0.0049 0.0328 0.0459
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0217 0.0472
Onchocerca volvulus 0.0049 0.0328 0.0672
Loa Loa (eye worm) hypothetical protein 0.0096 0.0817 0.1798
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0487 0.1309
Echinococcus granulosus metabotropic glutamate receptor 2 0.018 0.1691 0.2357
Echinococcus granulosus lysyl tRNA synthetase 0.0046 0.0299 0.0413
Plasmodium falciparum phd finger protein, putative 0.0032 0.0148 0.0094
Echinococcus granulosus tm gpcr rhodopsin 0.0049 0.0328 0.0454
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0217 0.0425
Echinococcus granulosus biogenic amine 5HT receptor 0.0049 0.0328 0.0454
Toxoplasma gondii sugar transporter ST2 0.0029 0.012 0.0095
Echinococcus multilocularis solute carrier family 22 0.0029 0.012 0.0116
Schistosoma mansoni glucose transport protein 0.0208 0.1982 0.2767
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2927 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0128 0.0071
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.0573 0.0568
Schistosoma mansoni glucose transporter 0.0029 0.012 0.0167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0049 0.0328 0.0325
Echinococcus multilocularis atrial natriuretic peptide receptor 0.002 0.0026 0.0022
Entamoeba histolytica PH domain containing protein kinase, putative 0.0043 0.0266 0.0827
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2927 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0111 0.0972 0.2101
Entamoeba histolytica protein kinase, putative 0.0065 0.0486 0.1588
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.012 0.0258
Brugia malayi 6-phosphofructokinase 0.0111 0.0972 0.2101
Schistosoma mansoni biogenic amine (5HT) receptor 0.0049 0.0328 0.0459
Loa Loa (eye worm) hypothetical protein 0.0051 0.0342 0.0748
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0004 0.0005
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0043 0.0266 0.0225
Brugia malayi Melatonin receptor type 1A 0.0049 0.0328 0.0672
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0198 0.0271
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0817 0.1757
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0972 0.2141
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0256 0.0357
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0217 0.1684
Schistosoma mansoni histamine h1 receptor 0.0049 0.0328 0.0459
Loa Loa (eye worm) hypothetical protein 0.0039 0.0224 0.0487

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3535 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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