TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 980.134 | Formula: C42H69N21O7
H donors: 7 H acceptors: 11 LogP: -4.92 Rotable bonds: 31
Rule of 5 violations (Lipinski): 4
SMILES: C#CCOCCOCCOCCNc1nc(nc(n1)N1CCN(CC1)C(=O)[C@@H](n1nnc(c1)[C@H](CC(=O)N)N)CC(=O)N)N1CCN(CC1)C(=O)[C@@H](n1nnc(c1)C([C@H](CC)C)N)CCCN=C(N)N
InChi: 1S/C42H69N21O7/c1-4-18-68-20-22-70-23-21-69-19-9-50-40-51-41(60-14-10-58(11-15-60)37(66)32(7-6-8-49-39(47)48)62-27-31(55-57-62)36(46)28(3)5-2)53-42(52-40)61-16-12-59(13-17-61)38(67)33(25-35(45)65)63-26-30(54-56-63)29(43)24-34(44)64/h1,26-29,32-33,36H,5-25,43,46H2,2-3H3,(H2,44,64)(H2,45,65)(H4,47,48,49)(H,50,51,52,53)/t28-,29-,32-,33-,36?/m0/s1
InChiKey: HGJKLPRDFDYLBF-SWSMJBPJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	snurportin 1		No references
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	polymerase (DNA directed) iota	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.004	0.0701	0.106
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.0777
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0404	0.0527
Plasmodium vivax	proline--tRNA ligase, putative	0.004	0.0701	0.0701
Toxoplasma gondii	sugar transporter ST1	0.0016	0.0201	0.0305
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0459	0.2038
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.0582	1
Trypanosoma brucei	chrX additional, unordered contigs	0.0007	0.0018	0.0253
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0018	0.0023
Echinococcus multilocularis	translational activator gcn1	0.0007	0.0004	0.0005
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.0777
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0701	1
Giardia lamblia	Sugar-proton symporter	0.0016	0.0201	0.346
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Plasmodium vivax	DNA repair protein REV1, putative	0.0007	0.0018	0.0018
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0318	0.5469
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0399	0.0603
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0399	0.1769
Echinococcus multilocularis	snurportin 1	0.0372	0.768	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0035	0.0597	0.0903
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0598	0.8529
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0598	0.0778
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0022	0.0318	0.8951
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0404	0.5771
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0356	0.892
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.8651
Trichomonas vaginalis	hypothetical protein	0.0007	0.0004	0.0018
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Onchocerca volvulus		0.0016	0.0201	0.5
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Toxoplasma gondii	sugar transporter ST3	0.0016	0.0201	0.0305
Plasmodium falciparum	transportin	0.0007	0.0004	0.0004
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.2253	1
Brugia malayi	Sugar transporter family protein	0.0016	0.0201	0.0894
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0399	0.0519
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0606	0.8651
Brugia malayi	hypothetical protein	0.0016	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Schistosoma mansoni	hypothetical protein	0.0372	0.768	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0701	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0201	0.5052
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0404	0.0612
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0356	0.0463
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Mycobacterium ulcerans	hypothetical protein	0.0007	0.0018	0.0445
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Onchocerca volvulus		0.0016	0.0201	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Entamoeba histolytica	HEAT repeat domain containing protein	0.0007	0.0004	0.0069
Plasmodium vivax	hexose transporter	0.0114	0.2253	0.2253
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0404	0.0404
Giardia lamblia	DNA damage repair protein	0.0007	0.0018	0.0305
Toxoplasma gondii	HEAT repeat-containing protein	0.0007	0.0004	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0262
Echinococcus granulosus	translational activator gcn1	0.0007	0.0004	0.0005
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.1769
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0459	0.6554
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Echinococcus multilocularis	calcium dependent protein kinase	0.0033	0.0552	0.0718
Trypanosoma brucei	DNA polymerase kappa, putative	0.0007	0.0018	0.0253
Onchocerca volvulus		0.0016	0.0201	0.5
Plasmodium falciparum	hexose transporter	0.0114	0.2253	0.2253
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.5689
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.5689
Brugia malayi	major facilitator superfamily protein	0.0016	0.0201	0.0894
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0184	0.3724	0.5632
Mycobacterium ulcerans	DNA polymerase IV	0.0023	0.0356	0.892
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.0777
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.768	1
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0201	0.0262
Trypanosoma cruzi	hexose transporter	0.0035	0.0606	0.8651
Echinococcus multilocularis	General substrate transporter	0.0098	0.1918	0.2497
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0262
Chlamydia trachomatis	proline--tRNA ligase	0.0012	0.0119	0.2978
Brugia malayi	kap beta 3 protein	0.0007	0.0004	0.0018
Schistosoma mansoni	ran	0.0026	0.0404	0.0527
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.0582	0.2583
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0023	0.0356	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Echinococcus granulosus	transportin 1	0.0007	0.0004	0.0005
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0598	0.0904
Leishmania major	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0404	0.1795
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0035	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0356	0.0463
Schistosoma mansoni	serine/threonine protein kinase	0.0035	0.0597	0.0777
Onchocerca volvulus		0.0016	0.0201	0.5
Trypanosoma brucei	sugar transporter, putative	0.0016	0.0201	0.2874
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0356	0.5075
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0356	0.0463
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0035	0.0597	0.0597
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0459	0.6554
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0035	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0582	0.0758
Onchocerca volvulus		0.0016	0.0201	0.5
Trypanosoma cruzi	DNA polymerase eta, putative	0.0007	0.0018	0.0253
Giardia lamblia	DINP protein human, muc B family	0.0023	0.0356	0.611
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0262
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0035	0.0597	0.0597
Plasmodium falciparum	importin beta, putative	0.0035	0.0598	0.0598
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0035	0.0597	0.0777
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.027	0.386
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.0777
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0026	0.0404	0.0404
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.2934
Trypanosoma brucei	DNA polymerase kappa, putative	0.0007	0.0018	0.0253
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.0777
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0114	0.2253	0.2934
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Onchocerca volvulus		0.0016	0.0201	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0262
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.8651
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0356	0.0463
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0356	0.0463
Entamoeba histolytica	Ran family GTPase	0.0026	0.0404	0.6776
Toxoplasma gondii	protein kinase, putative	0.0321	0.6612	1
Trypanosoma cruzi	hexose transporter, putative	0.0016	0.0201	0.2874
Trypanosoma brucei	hypothetical protein, conserved	0.0007	0.0018	0.0253
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0356	0.1578
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0399	1
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0399	1
Trypanosoma brucei	hypothetical protein, conserved	0.0007	0.0018	0.0253
Trypanosoma cruzi	sugar transporter, putative	0.0016	0.0201	0.2874
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0894
Plasmodium falciparum	DNA repair protein REV1, putative	0.0007	0.0018	0.0018
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0262
Schistosoma mansoni	glucose transport protein	0.0114	0.2253	0.2934
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0016	0.0201	0.0894
Trichomonas vaginalis	DNA polymerase eta, putative	0.0023	0.0356	0.1578
Schistosoma mansoni	DNA polymerase IV / kappa	0.0007	0.0018	0.0023
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0201	0.0262
Schistosoma mansoni	protein kinase	0.0035	0.0597	0.0777
Onchocerca volvulus		0.0016	0.0201	0.5
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0035	0.0597	0.8517
Trypanosoma brucei	glucose transporter 1E	0.0035	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.8651
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0262
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0201	0.0262
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0399	0.0399
Loa Loa (eye worm)	kap beta 3 protein	0.0007	0.0004	0.0005
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Loa Loa (eye worm)	sugar transporter	0.0114	0.2253	0.2934
Entamoeba histolytica	protein kinase, putative	0.0035	0.0597	1
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0356	0.0463
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0482	1	1
Brugia malayi	RNA, U transporter 1	0.0099	0.1947	0.8641
Trypanosoma cruzi	hypothetical protein, conserved	0.0007	0.0018	0.0253
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0204	0.2905
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.2934
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0459	0.2038
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0035	0.0597	0.0777
Leishmania major	DNA polymerase kappa, putative	0.0007	0.0018	0.0253
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0201	0.5052
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0009	0.005	0.071
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0016	0.0201	0.0201
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.2934
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0007	0.0018	0.0027
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Echinococcus granulosus	importin 5	0.0007	0.0004	0.0005
Leishmania major	protein kinase, putative	0.0035	0.0597	0.8517
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0606	0.8651
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.0606	0.8651
Schistosoma mansoni	importin beta-1	0.0035	0.0598	0.0778
Echinococcus granulosus	General substrate transporter	0.0098	0.1918	0.2497
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0582	0.0758
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.8651
Leishmania major	glucose transporter, lmgt2	0.0035	0.0606	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0201	0.0894
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0022	0.0318	0.8951
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0701	1
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0201	0.0894
Trypanosoma brucei	unspecified product	0.0016	0.0204	0.2905
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Trypanosoma brucei	Importin-beta N-terminal domain/HEAT-like repeat, putative	0.0007	0.0004	0.0059
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0404	0.5771
Brugia malayi	major facilitator superfamily protein	0.0016	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0606	0.269
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.2934
Brugia malayi	polk-prov protein	0.0007	0.0018	0.0079
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0035	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0598	0.8529
Trypanosoma brucei	DNA damage repair protein, putative	0.0007	0.0018	0.0253
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0262
Schistosoma mansoni	hypothetical protein	0.0114	0.2253	0.2934
Onchocerca volvulus	Putative transporter	0.0016	0.0201	0.5
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0262
Brugia malayi	hypothetical protein	0.0016	0.0201	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.2934
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0399	0.5689
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0606	0.269
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.0582	1
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0582	0.0758
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0606	0.8651
Loa Loa (eye worm)	sugar transporter	0.0016	0.0201	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Echinococcus multilocularis	importin 5	0.0007	0.0004	0.0005
Plasmodium vivax	transportin, putative	0.0007	0.0004	0.0004
Onchocerca volvulus		0.0016	0.0201	0.5
Echinococcus granulosus	dna polymerase eta	0.0023	0.0356	0.0463
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0201	0.5052
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0023	0.0356	0.5958
Giardia lamblia	Hexose transporter	0.0016	0.0201	0.346
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0012	0.0119	0.2978
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0119	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0597	0.0777
Plasmodium falciparum	protein kinase 7	0.0321	0.6612	0.6612
Entamoeba histolytica	protein kinase, putative	0.0035	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0035	0.0597	0.0597
Schistosoma mansoni	glucose transport protein	0.0114	0.2253	0.2934
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0598	0.0778
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0399	0.0519
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0333	0.1477
Brugia malayi	Sugar transporter family protein	0.0016	0.0201	0.0894
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.8651
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0582	0.0758
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0399	0.0519
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0404	0.5771
Brugia malayi	Sugar transporter family protein	0.0114	0.2253	1
Entamoeba histolytica	hypothetical protein	0.0028	0.0459	0.7695
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0023	0.0356	0.5075
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0035	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Loa Loa (eye worm)	importin-beta domain-containing protein	0.0007	0.0004	0.0005
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0598	0.0778
Trypanosoma cruzi	hypothetical protein, conserved	0.0007	0.0018	0.0253
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0035	0.0597	0.0777
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0399	1
Leishmania major	DNA damage repair protein, putative	0.0007	0.0018	0.0253
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0.0201	0.2874
Mycobacterium ulcerans	sugar transporter	0.0016	0.0201	0.5052
Schistosoma mansoni	importin-beta 2	0.0007	0.0004	0.0005
Toxoplasma gondii	facilitative glucose transporter GT1	0.0114	0.2253	0.3408
Schistosoma mansoni	protein kinase	0.0035	0.0597	0.0777
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0035	0.0597	0.0903
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.016	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trypanosoma brucei	unspecified product	0.0023	0.0356	0.5075
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0894
Toxoplasma gondii	sugar transporter ST2	0.0016	0.0201	0.0305
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0404	0.0527
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.004	0.0701	1
Trypanosoma cruzi	DNA damage repair protein, putative	0.0007	0.0018	0.0253
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0.0201	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Leishmania major	hypothetical protein, conserved	0.0016	0.0201	0.2874
Plasmodium falciparum	proline--tRNA ligase	0.004	0.0701	0.0701
Leishmania major	DNA polymerase eta, putative	0.0023	0.0356	0.5075
Onchocerca volvulus		0.0016	0.0201	0.5
Brugia malayi	Cam kinase protein 1	0.0035	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0606	0.269
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0184	0.3724	0.3724
Schistosoma mansoni	glucose transport protein	0.0114	0.2253	0.2934
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0356	0.0463
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0201	0.0894
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0356	0.5075
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0598	0.0598
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0606	0.269
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0016	0.0201	1
Echinococcus granulosus	snurportin 1	0.0372	0.768	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0184	0.3724	0.3724
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0035	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Onchocerca volvulus		0.0016	0.0201	0.5
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0399	0.0399
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0035	0.0597	0.2648
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0606	0.269
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0356	1
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0262
Leishmania major	hypothetical protein, conserved	0.0007	0.0004	0.0059
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0356	0.1578
Trypanosoma brucei	unspecified product	0.0016	0.0204	0.2905
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0016	0.0201	0.5664
Leishmania major	glucose transporter, lmgt1	0.0035	0.0606	0.8651
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0606	0.8651
Onchocerca volvulus		0.0016	0.0201	0.5
Trichomonas vaginalis	ran, putative	0.0026	0.0404	0.1795
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0204	0.2905
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0399	0.0519
Trypanosoma cruzi	DNA polymerase eta, putative	0.0023	0.0356	0.5075
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0606	0.8651
Trypanosoma brucei	glucose transporter 2A	0.0035	0.0606	0.8651
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.2934
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0399	0.6849
Trypanosoma cruzi	DNA damage repair protein, putative	0.0007	0.0018	0.0253
Schistosoma mansoni	glucose transporter	0.0016	0.0201	0.0262
Leishmania major	GTP-binding protein, putative	0.0026	0.0404	0.5771
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.0582	0.2583
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0023	0.0356	0.1578
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0606	0.8651
Trypanosoma brucei	DNA damage repair protein, putative	0.0007	0.0018	0.0253
Onchocerca volvulus		0.0016	0.0201	0.5
Leishmania major	glucose transporter, lmgt3	0.0035	0.0606	0.8651
Trypanosoma cruzi	glucose transporter, putative	0.0016	0.0201	0.2874
Toxoplasma gondii	BRCA1 C Terminus (BRCT) domain-containing protein	0.0007	0.0018	0.0027
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.0404	0.6948
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0582	0.0758
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0007	0.0018	0.0027
Schistosoma mansoni	sugar transporter	0.0016	0.0201	0.0262
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Schistosoma mansoni	ran	0.0026	0.0404	0.0527
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.0777
Trichomonas vaginalis	sugar transport protein, putative	0.0016	0.0201	0.0894
Onchocerca volvulus		0.0016	0.0201	0.5
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0035	0.0597	0.0597
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0356	0.5075
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0356	0.5075
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0201	0.0262
Brugia malayi	hypothetical protein	0.0016	0.0201	0.0894
Onchocerca volvulus		0.0016	0.0201	0.5
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0356	0.0463
Trypanosoma brucei	DNA polymerase kappa, putative	0.0016	0.0204	0.2905
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0201	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0448	0.0583
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0201	0.0262
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0035	0.0597	0.0777
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0356	0.0463
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0399	0.0519
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0404	0.0527
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0606	0.8651
Entamoeba histolytica	hypothetical protein	0.0025	0.0399	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0016	0.0201	0.0894
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0399	0.6849
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Echinococcus multilocularis	transportin 1	0.0007	0.0004	0.0005
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0114	0.2253	0.2934
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0606	0.269
Plasmodium vivax	sugar transporter, putative	0.0016	0.0201	0.0201
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.0582	0.9752
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0606	0.269
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0356	0.0463
Schistosoma mansoni	protein kinase	0.0035	0.0597	0.0777
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.0582	0.2583
Brugia malayi	Importin beta-1 subunit	0.0035	0.0598	0.2652
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0016	0.0201	0.5664
Leishmania major	DNA polymerase eta, putative	0.0007	0.0018	0.0253
Onchocerca volvulus		0.0016	0.0201	0.5
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0201	0.0262
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0582	0.0758
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0023	0.0356	0.5075
Trichomonas vaginalis	CAMK family protein kinase	0.0035	0.0597	0.2648
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0035	0.0597	0.0903
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0459	0.2038
Toxoplasma gondii	HEAT repeat-containing protein	0.0007	0.0004	0.0006
Onchocerca volvulus		0.0016	0.0201	0.5
Trichomonas vaginalis	myo-inositol transporter, putative	0.0016	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0016	0.0201	0.0262
Echinococcus granulosus	calcium dependent protein kinase	0.0033	0.0552	0.0718
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0.0201	0.2874
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.004	0.0701	1
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0201	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0201	0.0262

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 20 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182]	ChEMBL.	No reference
Potency (functional)	7.3078 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	23.0999 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1718129

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1487084