Detailed information for compound 1493758

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 640.555 | Formula: C29H39Cl2N5O7
  • H donors: 6 H acceptors: 8 LogP: 3.71 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 3
  • SMILES: CN([C@@H]1C(=C(C(=O)N)C(=O)[C@@]2([C@H]1C[C@@H]1Cc3c(Cl)nc(c(c3C(=O)C1=C2O)O)NCC(CN1CCCC1)(C)C)O)O)C.Cl
  • InChi: 1S/C29H38ClN5O7.ClH/c1-28(2,12-35-7-5-6-8-35)11-32-27-22(38)17-14(25(30)33-27)9-13-10-15-19(34(3)4)21(37)18(26(31)41)24(40)29(15,42)23(39)16(13)20(17)36;/h13,15,19,37-39,42H,5-12H2,1-4H3,(H2,31,41)(H,32,33);1H/t13-,15-,19-,29-;/m0./s1
  • InChiKey: PSBUQJHVDZPVSD-NVWOTOIASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii cytochrome p450 superfamily protein 0.0015 0.0081 0.0125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0443 0.0486
Entamoeba histolytica hypothetical protein 0.0036 0.0343 0.2959
Echinococcus granulosus zinc finger protein Ran binding 0.0155 0.1818 0.1995
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0129 0.0273
Brugia malayi YY1-associated factor 2 0.0155 0.1818 0.3429
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0091 0.0172
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1382 0.2607
Loa Loa (eye worm) hypothetical protein 0.0155 0.1818 0.3429
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0421 0.0794
Loa Loa (eye worm) hypothetical protein 0.0155 0.1818 0.3429
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0129 0.4371
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0137 0.0647
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0544 0.2914
Loa Loa (eye worm) hypothetical protein 0.0011 0.0031 0.0058
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0343 0.0376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0047 0.0088
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0137 0.0649
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0091 0.0172
Brugia malayi MH2 domain containing protein 0.012 0.1382 0.2607
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0137 0.1095
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0031 0.0058
Schistosoma mansoni zinc finger protein 0.0155 0.1818 0.3429
Schistosoma mansoni fusion 0.0155 0.1818 0.3429
Loa Loa (eye worm) hypothetical protein 0.0109 0.1244 0.2346
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0137 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0031 0.0058
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0011 0.0031 0.0034
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0435 0.5303 0.5303
Echinococcus multilocularis serine protein kinase ATM 0.0027 0.0227 0.0227
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0421 0.0462
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0137 0.0258
Trypanosoma cruzi cytochrome P450, putative 0.0052 0.0544 0.2914
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0435 0.5303 1
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0155 0.1818 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0137 0.0508
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0011 0.0031 0.014
Brugia malayi CHE-14 protein 0.0042 0.0421 0.0794
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0137 0.0137
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0137 0.0258
Schistosoma mansoni hypothetical protein 0.0435 0.5303 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0081 0.0153
Schistosoma mansoni hypothetical protein 0.0041 0.0402 0.0758
Echinococcus multilocularis 0.0015 0.0081 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0103 0.2006
Schistosoma mansoni cytochrome P450 0.0015 0.0081 0.0153
Schistosoma mansoni hypothetical protein 0.0036 0.0343 0.0646
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0343 0.0646
Brugia malayi SWIB/MDM2 domain containing protein 0.0435 0.5303 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0031 0.0058
Echinococcus multilocularis SWI:SNF matrix associated 0.0435 0.5303 0.5303
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.019 0.2345
Echinococcus multilocularis zinc finger protein Ran binding 0.0155 0.1818 0.1818
Echinococcus multilocularis ring and YY1 binding protein 0.0155 0.1818 0.1818
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0129 0.0026
Trypanosoma cruzi WLM domain containing protein, putative 0.0155 0.1818 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0129 0.0214
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0015 0.0081 0.0196
Echinococcus granulosus serine protein kinase ATM 0.0027 0.0227 0.0249
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.001 0.002 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0115 0.0217
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0103 0.2006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0137 0.0647
Entamoeba histolytica hypothetical protein 0.0036 0.0343 0.2959
Toxoplasma gondii exonuclease III APE 0.0019 0.0129 0.0214
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.019 0.2345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Echinococcus multilocularis GPCR, family 2 0.0016 0.0091 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0012 0.0047 0.0059
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0141 0.0346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0011 0.0031 0.0031
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0141 0.0238
Brugia malayi hypothetical protein 0.0036 0.0343 0.0646
Brugia malayi follicle stimulating hormone receptor 0.0224 0.2674 0.5043
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0443 0.0836
Leishmania major cytochrome p450-like protein 0.0052 0.0544 0.2665
Leishmania major hypothetical protein, conserved 0.0155 0.1818 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.018 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0047 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0443 0.0836
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.114 0.215
Onchocerca volvulus 0.0155 0.1818 0.3185
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0137 0.0318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0443 0.0836
Leishmania major hypothetical protein, conserved 0.0155 0.1818 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.002 0.0137 0.0321
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.1121 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.1121 0.1121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0137 0.015
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0544 0.1026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0031 0.0058
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0141 0.0267
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0137 0.0647
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0155 0.1818 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.1648 0.1648
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0141 0.0674
Schistosoma mansoni ap endonuclease 0.0019 0.0129 0.0243
Schistosoma mansoni hypothetical protein 0.0041 0.0402 0.0758
Toxoplasma gondii FATC domain-containing protein 0.0027 0.0227 0.04
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.019 0.1577
Schistosoma mansoni hypothetical protein 0.0034 0.0319 0.0602
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0224 0.2674 0.5043
Echinococcus multilocularis expressed conserved protein 0.0093 0.1047 0.1047
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0141 0.0051
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0129 0.0243
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0052 0.0544 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0115 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.1818 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.019 0.0625
Brugia malayi Cytochrome P450 family protein 0.0052 0.0544 0.1026
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0141 0.0535
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1382 0.2607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0141 0.0267
Brugia malayi Cytochrome P450 family protein 0.0015 0.0081 0.0153
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0137 0.0318
Brugia malayi brahma associated protein 60 kDa 0.0435 0.5303 1
Entamoeba histolytica recQ family DNA helicase 0.001 0.002 0.0043
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0141 0.0155
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0091 0.0091
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0137 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0443 0.0836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.1818 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0027 0.0227 0.0428
Echinococcus multilocularis bloom syndrome protein 0.002 0.0141 0.0141
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0103 0.2006
Schistosoma mansoni hypothetical protein 0.0041 0.0402 0.0758
Schistosoma mansoni hypothetical protein 0.0435 0.5303 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0091 0.0172
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0227 0.115
Onchocerca volvulus 0.0109 0.1244 0.2061
Schistosoma mansoni cellular tumor antigen P53 0.0109 0.1244 0.2346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Loa Loa (eye worm) hypothetical protein 0.0042 0.0421 0.0794
Giardia lamblia GTOR 0.0019 0.0137 0.6159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0081 0.0153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0115 0.0217
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0516 0.0972
Toxoplasma gondii ran binding protein 0.0155 0.1818 0.341
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0155 0.1818 0.3185
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0141 0.0238
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0137 0.0258
Schistosoma mansoni hypothetical protein 0.0155 0.1818 0.3429
Loa Loa (eye worm) hypothetical protein 0.0155 0.1818 0.3429
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0155 0.1818 0.3429
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0129 0.0603
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0435 0.5303 1
Chlamydia trachomatis SWIB complex protein 0.0435 0.5303 1
Leishmania major hypothetical protein, conserved 0.0155 0.1818 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0137 0.0229
Loa Loa (eye worm) cytochrome P450 0.0015 0.0081 0.0153
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0343 0.0343
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0137 0.0318
Schistosoma mansoni ap endonuclease 0.0019 0.0129 0.0243
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0155 0.1818 0.1818
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.1121 0.123
Entamoeba histolytica protein kinase rad3, putative 0.0011 0.0031 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0137 0.0137
Echinococcus multilocularis SWI:SNF matrix associated 0.0435 0.5303 0.5303
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.019 1
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0155 0.1818 0.341
Echinococcus granulosus GPCR family 2 0.0016 0.0091 0.01
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Trypanosoma cruzi hypothetical protein, conserved 0.0155 0.1818 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0137 0.0647
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0016 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0091 0.0172
Plasmodium vivax hypothetical protein, conserved 0.0435 0.5303 1
Chlamydia trachomatis DNA topoisomerase I 0.0435 0.5303 1
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0141 1
Entamoeba histolytica hypothetical protein 0.0036 0.0343 0.2959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0115 0.0189
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0155 0.1818 0.3429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0129 0.1025
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0141 0.0267
Trypanosoma brucei cytochrome P450, putative 0.0052 0.0544 0.2809
Loa Loa (eye worm) hypothetical protein 0.005 0.0516 0.0972
Loa Loa (eye worm) hypothetical protein 0.002 0.0141 0.0267
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0018 0.0115 0.0217
Schistosoma mansoni DNA helicase recq5 0.002 0.0141 0.0267
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0155 0.1818 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0137 0.0318
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0421 0.0462
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0155 0.1818 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.019 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0047 0.0088
Echinococcus granulosus ring and YY1 binding protein 0.0155 0.1818 0.1995
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0358
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.002 0.0038
Mycobacterium ulcerans hypothetical protein 0.0024 0.019 0.2345
Trypanosoma brucei hypothetical protein, conserved 0.0155 0.1818 1
Echinococcus granulosus SWI:SNF matrix associated 0.0435 0.5303 0.5819
Brugia malayi AMP-binding enzyme family protein 0.0024 0.019 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.019 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0227 0.0428
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0137 0.1095
Loa Loa (eye worm) CYP4Cod1 0.0052 0.0544 0.1026
Trypanosoma cruzi WLM domain containing protein, putative 0.0155 0.1818 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0495 0.0495
Schistosoma mansoni RNA binding protein 0.0155 0.1818 0.3429
Echinococcus granulosus expressed conserved protein 0.0093 0.1047 0.1149
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0137 0.0258
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0129 0.0243
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0027 0.0227 0.1018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0358
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0141 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Loa Loa (eye worm) hypothetical protein 0.0037 0.0357 0.0674
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0027 0.0227 0.0428
Loa Loa (eye worm) hypothetical protein 0.0155 0.1818 0.3429
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0443 0.0443
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0155 0.1818 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0435 0.5303 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0091 0.01
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0435 0.5303 1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0141 0.0141
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.019 0.2345
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0115 0.3117
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0141 0.0267
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.002 0.0009
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0172
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0155 0.1818 0.1818
Entamoeba histolytica hypothetical protein 0.0027 0.0227 0.1912
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.019 1
Brugia malayi brahma associated protein 60 kDa 0.0435 0.5303 1
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0435 0.5303 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0015 0.0081 0.034
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0544 0.1026
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0141 0.0267
Brugia malayi AMP-binding enzyme family protein 0.0024 0.019 0.0358
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0435 0.5303 0.5819
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0129 0.0141
Entamoeba histolytica recQ family helicase, putative 0.002 0.0141 0.1138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.019 0.2345
Onchocerca volvulus 0.0155 0.1818 0.3185
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0172
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0141 0.0267
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.1648 0.1808
Schistosoma mansoni hypothetical protein 0.0435 0.5303 1
Echinococcus granulosus bloom syndrome protein 0.002 0.0141 0.0155
Loa Loa (eye worm) brahma associated protein 0.0435 0.5303 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.018 0.0891
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0137 0.0318
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0129 0.0464
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.019 0.2345
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0155 0.1818 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0129 0.1024
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0516 0.0972
Loa Loa (eye worm) hypothetical protein 0.0034 0.0319 0.0602
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.019 0.2345
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0129 0.0243
Onchocerca volvulus 0.0155 0.1818 0.3185
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0129 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0435 0.5303 1
Brugia malayi cytochrome P450 0.0015 0.0081 0.0153
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0081 0.0089
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0155 0.1818 0.3429
Loa Loa (eye worm) hypothetical protein 0.0155 0.1818 0.3429
Onchocerca volvulus 0.0155 0.1818 0.3185
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.019 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Schistosoma mansoni patched 1 0.0042 0.0421 0.0794
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0081 0.034
Schistosoma mansoni brg-1 associated factor 0.0435 0.5303 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0011 0.0031 0.0059
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.019 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0011 0.0031 0.0058
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0155 0.1818 0.3429
Loa Loa (eye worm) hypothetical protein 0.0052 0.0539 0.1017
Loa Loa (eye worm) RecQ helicase 0.002 0.0141 0.0267
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0137 0.0508
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0155 0.1818 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0115 0.0731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0031 0.0058
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0443 0.0443
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0137 0.0258
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0421 0.0421
Entamoeba histolytica hypothetical protein 0.0036 0.0343 0.2959
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0319 0.0602
Echinococcus multilocularis protein patched 0.0042 0.0421 0.0421
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0141 0.0051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0443 0.0836
Echinococcus granulosus tumor protein p63 0.0742 0.9113 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0516 0.0972
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.1121 0.2115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0115 0.0217
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0141 0.0141
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0091 0.01
Onchocerca volvulus 0.0435 0.5303 1
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0155 0.1818 0.3283
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0031 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0443 0.0486
Schistosoma mansoni hypothetical protein 0.0016 0.0091 0.0172
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0137 0.0508
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0137 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0129 1
Schistosoma mansoni TRABID protein (C64 family) 0.0155 0.1818 0.3429
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0103 0.2006
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0137 0.0508
Brugia malayi Cytochrome P450 family protein 0.0052 0.0544 0.1026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0011 0.0031 0.0058
Schistosoma mansoni hypothetical protein 0.0015 0.0081 0.0153
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.019 0.2345
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.019 0.1577
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0015 0.0081 0.034
Schistosoma mansoni DNA helicase recq1 0.002 0.0141 0.0267
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0129 0.0243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0011 0.0031 0.0058
Trypanosoma brucei hypothetical protein, conserved 0.0155 0.1818 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0155 0.1818 0.1995
Brugia malayi AMP-binding enzyme family protein 0.0024 0.019 0.0358
Echinococcus granulosus Zinc finger RanBP2 type 0.0155 0.1818 0.1995
Loa Loa (eye worm) hypothetical protein 0.0099 0.1121 0.2115
Loa Loa (eye worm) hypothetical protein 0.0024 0.019 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0129 0.5
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.019 0.1577
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0435 0.5303 1
Schistosoma mansoni hypothetical protein 0.0041 0.0402 0.0758
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0421 0.0794
Leishmania major hypothetical protein, conserved 0.0155 0.1818 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0435 0.5303 0.5303
Echinococcus multilocularis tumor protein p63 0.0742 0.9113 0.9113
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0141 0.0155
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0091 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0137 0.0258
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0137 0.0647
Leishmania major hypothetical protein, conserved 0.0155 0.1818 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 2 ug ml-1 Antibacterial activity against Escherichia coli ATCC 25922 by CLSI M07-A8 method ChEMBL. 21302930
MIC (functional) = 8 ug ml-1 Antibacterial activity against tetracycline-resistant Escherichia coli isolate 155 harboring tet(A) gene by CLSI M07-A8 method ChEMBL. 21302930

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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