TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 386.251 | Formula: C16H8F6N4O
H donors: 2 H acceptors: 2 LogP: 3.87 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=c1cc([nH]c2n1nc(c2c1c[nH]c2c1cccc2)C(F)(F)F)C(F)(F)F
InChi: 1S/C16H8F6N4O/c17-15(18,19)10-5-11(27)26-14(24-10)12(13(25-26)16(20,21)22)8-6-23-9-4-2-1-3-7(8)9/h1-6,23-24H
InChiKey: DUPYDQMGLWCHFK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	zeta tubulin, putative	0.0114	0.2099	0.2099
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0114	0.2099	1
Schistosoma mansoni	tubulin subunit alpha	0.0361	0.754	0.754
Leishmania major	beta tubulin	0.0473	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0149	0.2861	0.2861
Trypanosoma cruzi	epsilon tubulin, putative	0.0263	0.5373	0.5373
Leishmania major	beta tubulin	0.0473	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.037	0.037
Entamoeba histolytica	hypothetical protein	0.0036	0.037	0.037
Echinococcus granulosus	tubulin alpha 3 chain	0.0361	0.754	0.754
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.037	0.037
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Leishmania major	DNA polymerase eta, putative	0.0044	0.0562	0.0562
Leishmania major	beta tubulin	0.0473	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0361	0.754	0.754
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0007	0.0007
Leishmania major	beta tubulin	0.0473	1	1
Loa Loa (eye worm)	hypothetical protein	0.0212	0.4265	0.4265
Brugia malayi	isocitrate dehydrogenase	0.0031	0.0278	0.0278
Trichomonas vaginalis	tubulin beta chain, putative	0.0149	0.2861	0.2861
Echinococcus multilocularis	Tubulin beta 2C chain	0.0473	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.0114	0.2099	0.2099
Trypanosoma brucei	alpha tubulin	0.0361	0.754	0.754
Toxoplasma gondii	alpha-tubulin I, putative	0.0361	0.754	0.754
Brugia malayi	Tubulin beta chain	0.0114	0.2099	0.2099
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0031	0.0278	0.0278
Trypanosoma cruzi	tubulin gamma chain	0.0263	0.5373	0.5373
Mycobacterium ulcerans	cell division protein FtsZ	0.0114	0.2099	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0149	0.2861	0.2861
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0114	0.2099	0.2099
Echinococcus granulosus	Tubulin beta 2C chain	0.0473	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Leishmania major	beta tubulin	0.0473	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0684	0.0684
Trypanosoma brucei	tubulin delta chain	0.0114	0.2099	0.2099
Onchocerca volvulus		0.0149	0.2861	0.5
Leishmania major	beta tubulin	0.0473	1	1
Trypanosoma brucei	zeta tubulin	0.0114	0.2099	0.2099
Echinococcus granulosus	Tubulin alpha 1 chain	0.0361	0.754	0.754
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Echinococcus granulosus	tubulin alpha 1C chain	0.0361	0.754	0.754
Echinococcus granulosus	Tubulin beta 2C chain	0.0473	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0562	0.0562
Trypanosoma brucei	alpha tubulin	0.0361	0.754	0.754
Echinococcus granulosus	tubulin alpha chain	0.0361	0.754	0.754
Plasmodium falciparum	alpha tubulin 2	0.0361	0.754	0.754
Echinococcus granulosus	tubulin beta 1 chain	0.0473	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0361	0.754	0.754
Echinococcus granulosus	tubulin alpha 3 chain	0.0361	0.754	0.754
Loa Loa (eye worm)	transcription factor SMAD2	0.0238	0.4817	0.4817
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0114	0.2099	0.2099
Trichomonas vaginalis	tubulin, putative	0.0473	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0361	0.754	0.754
Entamoeba histolytica	tubulin family protein	0.0473	1	1
Leishmania major	beta tubulin	0.0473	1	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.0278	0.0278
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0007	0.0007
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0007	0.0032
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0361	0.754	0.754
Echinococcus granulosus	tubulin alpha chain	0.0361	0.754	0.754
Trichomonas vaginalis	tubulin beta chain, putative	0.0361	0.754	0.754
Echinococcus granulosus	tubulin alpha chain	0.0361	0.754	0.754
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0114	0.2099	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Entamoeba histolytica	hypothetical protein	0.0036	0.037	0.037
Loa Loa (eye worm)	tubulin beta-2A chain	0.0473	1	1
Trypanosoma brucei	epsilon tubulin	0.0263	0.5373	0.5373
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0141	0.0141
Schistosoma mansoni	tubulin subunit beta	0.0473	1	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0238	0.4817	0.4817
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0336	0.0336
Echinococcus granulosus	Tubulin beta 2C chain	0.0473	1	1
Echinococcus granulosus	tubulin subunit TubB	0.0361	0.754	0.754
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Giardia lamblia	Beta tubulin	0.0473	1	1
Echinococcus multilocularis	beta tubulin	0.0473	1	1
Giardia lamblia	Epsilon tubulin	0.0114	0.2099	0.2099
Trypanosoma cruzi	tubulin delta chain	0.0114	0.2099	0.2099
Echinococcus granulosus	tubulin beta 4A class IVa	0.0473	1	1
Giardia lamblia	Gamma tubulin	0.0263	0.5373	0.5373
Schistosoma mansoni	tubulin subunit alpha	0.0114	0.2099	0.2099
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Echinococcus multilocularis	tubulin alpha 1C chain	0.0361	0.754	0.754
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Trypanosoma brucei	beta tubulin	0.0473	1	1
Echinococcus granulosus	beta tubulin	0.0473	1	1
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0007	0.0007
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0361	0.754	0.754
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0007	0.0007
Trichomonas vaginalis	tubulin beta chain, putative	0.0361	0.754	0.754
Brugia malayi	MH2 domain containing protein	0.0238	0.4817	0.4817
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Echinococcus granulosus	Tubulin alpha 1 chain	0.0361	0.754	0.754
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.0278	0.0278
Toxoplasma gondii	beta-tubulin, putative	0.0473	1	1
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0007	0.0032
Echinococcus granulosus	alpha tubulin	0.0361	0.754	0.754
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Leishmania major	delta tubulin, putative	0.0114	0.2099	0.2099
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0031	0.0278	0.0278
Echinococcus multilocularis	tubulin gamma 1 chain	0.0263	0.5373	0.5373
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.0278	0.0278
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0361	0.754	0.754
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0141	0.0141
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.0278	0.0278
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Echinococcus granulosus	dna polymerase eta	0.0044	0.0562	0.0562
Echinococcus multilocularis	tubulin subunit beta	0.0473	1	1
Echinococcus multilocularis	tubulin epsilon chain	0.0263	0.5373	0.5373
Leishmania major	beta tubulin	0.0473	1	1
Schistosoma mansoni	hypothetical protein	0.0337	0.7011	0.7011
Plasmodium vivax	tubulin alpha chain, putative	0.0361	0.754	0.754
Entamoeba histolytica	tubulin alpha-1 chain	0.0361	0.754	0.754
Brugia malayi	Tubulin alpha-2 chain	0.0361	0.754	0.754
Echinococcus granulosus	Tubulin beta 2C chain	0.0473	1	1
Loa Loa (eye worm)	hypothetical protein	0.0361	0.754	0.754
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0141	0.0141
Echinococcus granulosus	tubulin delta chain	0.0114	0.2099	0.2099
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0007	0.0032
Loa Loa (eye worm)	tubulin alpha 2	0.0098	0.1752	0.1752
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0361	0.754	0.754
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0361	0.754	0.754
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0684	0.0684
Echinococcus multilocularis	tubulin beta 1 chain	0.0473	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0361	0.754	0.754
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.0278	0.0278
Echinococcus multilocularis	Tubulin beta 2C chain	0.0473	1	1
Leishmania major	beta tubulin	0.0473	1	1
Trypanosoma brucei	epsilon tubulin	0.0263	0.5373	0.5373
Trichomonas vaginalis	tubulin beta chain, putative	0.0361	0.754	0.754
Schistosoma mansoni	tubulin subunit beta	0.0473	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0114	0.2099	0.2099
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0007	0.0032
Trichomonas vaginalis	tubulin beta chain, putative	0.0361	0.754	0.754
Loa Loa (eye worm)	tubulin alpha chain	0.0361	0.754	0.754
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0361	0.754	0.754
Leishmania major	beta tubulin	0.0473	1	1
Trypanosoma brucei	tubulin gamma chain	0.0263	0.5373	0.5373
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0007	0.0007
Plasmodium vivax	tubulin alpha chain, putative	0.0361	0.754	0.754
Brugia malayi	Tubulin alpha chain	0.0114	0.2099	0.2099
Entamoeba histolytica	tubulin gamma chain	0.0263	0.5373	0.5373
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Echinococcus multilocularis	tubulin alpha	0.0263	0.5373	0.5373
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.0278	0.0278
Echinococcus multilocularis	Tubulin beta 2C chain	0.0473	1	1
Giardia lamblia	Alpha-tubulin	0.0361	0.754	0.754
Giardia lamblia	Alpha-tubulin	0.0361	0.754	0.754
Echinococcus granulosus	beta tubulin	0.0473	1	1
Schistosoma mansoni	alpha tubulin	0.0361	0.754	0.754
Leishmania major	beta tubulin	0.0473	1	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0007	0.0007
Giardia lamblia	Beta tubulin	0.0473	1	1
Treponema pallidum	cell division protein FtsZ	0.0114	0.2099	1
Trypanosoma cruzi	alpha tubulin, putative	0.0361	0.754	0.754
Trichomonas vaginalis	tubulin, putative	0.0114	0.2099	0.2099
Plasmodium vivax	tubulin gamma chain, putative	0.0263	0.5373	0.5373
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.2099	0.2099
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0336	0.0336
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.0562	0.0562
Trichomonas vaginalis	conserved hypothetical protein	0.0114	0.2099	0.2099
Plasmodium falciparum	tubulin gamma chain	0.0263	0.5373	0.5373
Brugia malayi	alpha-tubulin	0.0361	0.754	0.754
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0141	0.0141
Trypanosoma brucei	beta tubulin	0.0473	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0473	1	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0361	0.754	0.754
Trypanosoma brucei	alpha tubulin	0.0361	0.754	0.754
Plasmodium falciparum	alpha tubulin 1	0.0361	0.754	0.754
Loa Loa (eye worm)	tubulin beta-1 chain	0.0473	1	1
Schistosoma mansoni	tubulin subunit beta	0.0473	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0361	0.754	0.754
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Leishmania major	gamma-tubulin	0.0263	0.5373	0.5373
Echinococcus multilocularis	beta tubulin	0.0473	1	1
Loa Loa (eye worm)	tubulin gamma chain	0.0263	0.5373	0.5373
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0141	0.0141
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.037	0.037
Echinococcus granulosus	tubulin gamma 1 chain	0.0263	0.5373	0.5373
Trypanosoma brucei	alpha tubulin	0.0361	0.754	0.754
Plasmodium falciparum	tubulin delta chain, putative	0.0114	0.2099	0.2099
Trypanosoma brucei	beta tubulin	0.0473	1	1
Plasmodium vivax	delta tubulin, putative	0.0114	0.2099	0.2099
Toxoplasma gondii	alpha tubulin TUBA1	0.0361	0.754	0.754
Echinococcus granulosus	Tubulin beta 2C chain	0.0473	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0361	0.754	0.754
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0247	0.5027	0.5027
Echinococcus granulosus	tubulin alpha	0.0263	0.5373	0.5373
Echinococcus multilocularis	tubulin delta chain	0.0114	0.2099	0.2099
Schistosoma mansoni	tubulin subunit epsilon	0.0263	0.5373	0.5373
Loa Loa (eye worm)	BEN-1 protein	0.0473	1	1
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Loa Loa (eye worm)	hypothetical protein	0.005	0.0684	0.0684
Loa Loa (eye worm)	tubulin alpha 2	0.0247	0.5027	0.5027
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0007	0.0007
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0031	0.0278	0.1325
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0684	0.0684
Trypanosoma brucei	unspecified product	0.0019	0.0007	0.0007
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.0278	0.0278
Echinococcus multilocularis	Tubulin beta 2C chain	0.0473	1	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0031	0.0278	0.0278
Schistosoma mansoni	alpha tubulin	0.0361	0.754	0.754
Trypanosoma brucei	beta tubulin	0.0263	0.5373	0.5373
Loa Loa (eye worm)	tubulin beta chain	0.0114	0.2099	0.2099
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0007	0.0007
Leishmania major	zeta tubulin, putative	0.0114	0.2099	0.2099
Echinococcus multilocularis	tubulin alpha chain	0.0361	0.754	0.754
Echinococcus multilocularis	hypothetical protein	0.0361	0.754	0.754
Loa Loa (eye worm)	BEN-1 protein	0.0473	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0361	0.754	0.754
Schistosoma mansoni	tubulin subunit alpha	0.0361	0.754	0.754
Loa Loa (eye worm)	tubulin alpha 2	0.0247	0.5027	0.5027
Echinococcus multilocularis	Tubulin beta 2C chain	0.0473	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0263	0.5373	0.5373
Trichomonas vaginalis	tubulin, putative	0.0149	0.2861	0.2861
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0031	0.0278	0.0278
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0149	0.2861	0.2861
Schistosoma mansoni	tubulin subunit beta	0.0114	0.2099	0.2099
Leishmania major	beta tubulin	0.0473	1	1
Brugia malayi	Isocitrate dehydrogenase	0.0031	0.0278	0.0278
Echinococcus granulosus	tubulin alpha chain	0.0361	0.754	0.754
Plasmodium falciparum	tubulin beta chain	0.0473	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0263	0.5373	0.5373
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0212	0.4265	0.4265
Brugia malayi	Tubulin gamma chain	0.0263	0.5373	0.5373
Schistosoma mansoni	tubulin subunit beta	0.0473	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0473	1	1
Trypanosoma cruzi	zeta tubulin, putative	0.0114	0.2099	0.2099
Leishmania major	hypothetical protein, conserved	0.0025	0.0141	0.0141
Toxoplasma gondii	beta tubulin	0.0473	1	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0473	1	1
Echinococcus multilocularis	dna polymerase eta	0.0044	0.0562	0.0562
Leishmania major	beta tubulin	0.0473	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0361	0.754	0.754
Leishmania major	DNA polymerase eta, putative	0.0031	0.0272	0.0272
Entamoeba histolytica	hypothetical protein	0.0036	0.037	0.037
Schistosoma mansoni	hypothetical protein	0.0036	0.037	0.037
Plasmodium vivax	tubulin beta chain, putative	0.0473	1	1
Brugia malayi	Cell division protein ftsZ	0.0114	0.2099	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0247	0.5027	0.5027
Schistosoma mansoni	tubulin subunit gamma	0.0263	0.5373	0.5373
Loa Loa (eye worm)	tubulin beta chain	0.0473	1	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0361	0.754	0.754
Echinococcus multilocularis	tubulin alpha chain	0.0361	0.754	0.754
Schistosoma mansoni	DNA polymerase eta	0.0044	0.0562	0.0562
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0031	0.0278	0.0278
Echinococcus multilocularis	isocitrate dehydrogenase	0.0031	0.0278	0.0278
Trypanosoma brucei	epsilon tubulin	0.0263	0.5373	0.5373
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0473	1	1
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Leishmania major	beta tubulin	0.0473	1	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0007	0.0007
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0007	0.0007
Giardia lamblia	Beta tubulin	0.0473	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0247	0.5027	0.5027
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0007	0.0007
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0141	0.0141
Plasmodium vivax	tubulin epsilon chain, putative	0.0263	0.5373	0.5373
Trichomonas vaginalis	tubulin gamma chain, putative	0.0263	0.5373	0.5373
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Trypanosoma brucei	beta tubulin	0.0473	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0263	0.5373	0.5373
Leishmania major	beta tubulin	0.0473	1	1
Loa Loa (eye worm)	beta-tubulin	0.0473	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0361	0.754	0.754
Brugia malayi	hypothetical protein	0.0036	0.037	0.037
Echinococcus multilocularis	tubulin alpha chain	0.0361	0.754	0.754
Trypanosoma cruzi	zeta tubulin, putative	0.0114	0.2099	0.2099
Brugia malayi	tubulin alpha-2 chain	0.0361	0.754	0.754
Entamoeba histolytica	tubulin alpha chain, putative	0.0361	0.754	0.754
Entamoeba histolytica	tubulin family protein	0.0473	1	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0007	0.0007
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0141	0.0141
Echinococcus multilocularis	tubulin subunit TubB	0.0361	0.754	0.754
Schistosoma mansoni	hypothetical protein	0.0034	0.0336	0.0336
Echinococcus multilocularis	geminin	0.0337	0.7011	0.7011
Trichomonas vaginalis	tubulin beta chain, putative	0.0473	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0361	0.754	0.754
Trypanosoma cruzi	tubulin delta chain	0.0114	0.2099	0.2099
Trichomonas vaginalis	tubulin alpha chain, putative	0.0473	1	1
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0007	0.0007
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0473	1	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0272	0.0272
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0007	0.0007
Brugia malayi	Tubulin beta chain	0.0149	0.2861	0.2861
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Echinococcus multilocularis	peroxisome assembly protein 26	0.0361	0.754	0.754
Trypanosoma cruzi	beta tubulin, putative	0.0473	1	1
Brugia malayi	hypothetical protein	0.0025	0.0141	0.0141
Leishmania major	beta tubulin	0.0473	1	1
Schistosoma mansoni	tubulin subunit beta	0.0473	1	1
Echinococcus granulosus	geminin	0.0337	0.7011	0.7011
Trypanosoma brucei	DNA polymerase eta, putative	0.0044	0.0562	0.0562
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0031	0.0278	0.0278
Leishmania major	beta tubulin	0.0473	1	1
Schistosoma mansoni	alpha tubulin	0.0361	0.754	0.754
Entamoeba histolytica	hypothetical protein	0.0036	0.037	0.037
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Echinococcus multilocularis	tubulin alpha 1C chain	0.0361	0.754	0.754
Trichomonas vaginalis	tubulin gamma chain, putative	0.0114	0.2099	0.2099
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0031	0.0278	0.0278
Echinococcus granulosus	tubulin alpha 1C chain	0.0361	0.754	0.754
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Echinococcus granulosus	tubulin alpha chain	0.0361	0.754	0.754
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0473	1	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Echinococcus granulosus	tubulin subunit beta	0.0473	1	1
Brugia malayi	beta-tubulin, identical	0.0473	1	1
Trichomonas vaginalis	tubulin, putative	0.0149	0.2861	0.2861
Trypanosoma brucei	alpha tubulin, putative	0.0149	0.2861	0.2861
Echinococcus granulosus	tubulin epsilon chain	0.0263	0.5373	0.5373
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0263	0.5373	0.5373
Schistosoma mansoni	tubulin subunit beta	0.0473	1	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0031	0.0278	0.0278
Brugia malayi	Tubulin alpha chain	0.0361	0.754	0.754
Schistosoma mansoni	tubulin subunit alpha	0.0361	0.754	0.754
Leishmania major	epsilon tubulin, putative	0.0263	0.5373	0.5373
Brugia malayi	tubulin alpha chain - mouse	0.0361	0.754	0.754
Trypanosoma cruzi	DNA polymerase eta, putative	0.0031	0.0272	0.0272
Trypanosoma cruzi	DNA polymerase eta, putative	0.0044	0.0562	0.0562
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.0278	0.0278
Schistosoma mansoni	tubulin subunit delta	0.0114	0.2099	0.2099
Leishmania major	beta tubulin	0.0473	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0007	0.0007
Trichomonas vaginalis	tubulin beta chain, putative	0.0361	0.754	0.754
Giardia lamblia	Delta tubulin	0.0114	0.2099	0.2099
Schistosoma mansoni	hypothetical protein	0.0337	0.7011	0.7011
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0007	0.0007
Trichomonas vaginalis	tubulin alpha chain, putative	0.0149	0.2861	0.2861
Trypanosoma cruzi	epsilon tubulin, putative	0.0263	0.5373	0.5373
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0212	0.4265	0.4265
Leishmania major	alpha tubulin	0.0361	0.754	0.754
Mycobacterium leprae	cell division protein FtsZ	0.0114	0.2099	0.5
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0007	0.0007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1689651

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1498267