TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 352.462 | Formula: C20H30F2N2O
H donors: 1 H acceptors: 1 LogP: 3.93 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N[C@@H]([C@@H]1CC[C@H](CC1)N(C(=O)C(C)(C)C)C)Cc1cc(F)ccc1F
InChi: 1S/C20H30F2N2O/c1-20(2,3)19(25)24(4)16-8-5-13(6-9-16)18(23)12-14-11-15(21)7-10-17(14)22/h7,10-11,13,16,18H,5-6,8-9,12,23H2,1-4H3/t13-,16-,18-/m1/s1
InChiKey: XUVZILXTMHUZNS-MZMPZRCHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dipeptidyl-peptidase 9	Starlite/ChEMBL	References
Homo sapiens	dipeptidyl-peptidase 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania infantum	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_128614	All targets in OG5_128614
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	Dipeptidyl peptidase 9	Get druggable targets OG5_129743	All targets in OG5_129743
Leishmania braziliensis	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	Get druggable targets OG5_128614	All targets in OG5_128614
Trypanosoma brucei gambiense	dipeptidyl-peptidase 8-like serine protease	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma japonicum	ko:K01278 dipeptidyl-peptidase 4, putative	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus multilocularis	Dipeptidyl peptidase 9	Get druggable targets OG5_129743	All targets in OG5_129743
Loa Loa (eye worm)	prolyl oligopeptidase	Get druggable targets OG5_128614	All targets in OG5_128614
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129743	All targets in OG5_129743
Candida albicans	dipeptidyl aminopeptidase B	Get druggable targets OG5_128614	All targets in OG5_128614
Schistosoma japonicum	ko:K08656 dipeptidyl-peptidase 9, putative	Get druggable targets OG5_129743	All targets in OG5_129743
Brugia malayi	prolyl oligopeptidase family protein	Get druggable targets OG5_129743	All targets in OG5_129743
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	Get druggable targets OG5_129743	All targets in OG5_129743
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	Get druggable targets OG5_128614	All targets in OG5_128614
Leishmania donovani	serine peptidase, Clan SC, Family S9B	Get druggable targets OG5_129743	All targets in OG5_129743

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0208	0.7092	1
Echinococcus multilocularis	roundabout 2	0.0089	0.2266	0.2266
Brugia malayi	Fibronectin type III domain containing protein	0.0058	0.101	0.101
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0058	0.101	0.101
Loa Loa (eye worm)	lethal protein 805	0.0058	0.101	0.101
Brugia malayi	Protein-tyrosine phosphatase	0.0058	0.101	0.101
Brugia malayi	hypothetical protein	0.0106	0.2956	0.2956
Onchocerca volvulus		0.0058	0.101	0.101
Echinococcus multilocularis	anosmin 1	0.0058	0.101	0.101
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0073	0.1631	0.1631
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0058	0.101	0.101
Schistosoma mansoni	protein tyrosine phosphatase	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0089	0.2266	0.2266
Echinococcus multilocularis	neuroglian	0.0063	0.1222	0.1222
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0058	0.101	0.101
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0208	0.7092	1
Onchocerca volvulus		0.0058	0.101	0.101
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0089	0.2266	0.2266
Echinococcus granulosus	contactin	0.0089	0.2266	0.2266
Brugia malayi	Fibronectin type III domain containing protein	0.0106	0.2956	0.2956
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2956	0.2956
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0058	0.101	0.1424
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0058	0.101	0.101
Brugia malayi	Fibronectin type III domain containing protein	0.0058	0.101	0.101
Echinococcus multilocularis	Immunoglobulin	0.0048	0.06	0.06
Echinococcus granulosus	roundabout 2	0.0089	0.2266	0.2266
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0073	0.1631	0.1631
Echinococcus multilocularis	titin	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0058	0.101	0.101
Onchocerca volvulus		0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Schistosoma mansoni	hypothetical protein	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0108	0.3018	0.3018
Schistosoma mansoni	titin	0.0073	0.1631	0.1631
Brugia malayi	Fibronectin type III domain containing protein	0.0058	0.101	0.101
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0208	0.7092	1
Brugia malayi	protein unc-22	0.0073	0.1631	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1631	0.1631
Echinococcus multilocularis	anosmin 1	0.0058	0.101	0.101
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0058	0.101	0.1424
Echinococcus granulosus	roundabout 2	0.0137	0.4212	0.4212
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0089	0.2266	0.2266
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0073	0.1631	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0048	0.06	0.06
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0048	0.06	0.06
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0058	0.101	0.101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2266	0.2266
Schistosoma mansoni	ephrin receptor	0.0075	0.1702	0.1702
Brugia malayi	RNA, U transporter 1	0.0059	0.1063	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Echinococcus multilocularis	anosmin 1	0.0058	0.101	0.101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0081	0.1927	0.1927
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0208	0.7092	0.7092
Echinococcus granulosus	Fibronectin type III	0.0058	0.101	0.101
Schistosoma mansoni	cell adhesion molecule	0.0073	0.1631	0.1631
Echinococcus granulosus	Netrin receptor DCC	0.0058	0.101	0.101
Brugia malayi	hypothetical protein	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Onchocerca volvulus		0.0058	0.101	0.101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0073	0.1631	0.1631
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0058	0.101	0.101
Onchocerca volvulus		0.0073	0.1631	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2956	0.2956
Brugia malayi	SPRY domain containing protein	0.0058	0.101	0.101
Brugia malayi	myotactin form B	0.0058	0.101	0.101
Echinococcus granulosus	anosmin 1	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0106	0.2956	0.2956
Schistosoma mansoni	cell adhesion molecule	0.0073	0.1631	0.1631
Onchocerca volvulus		0.0073	0.1631	0.1631
Echinococcus multilocularis	roundabout 2	0.0089	0.2266	0.2266
Schistosoma mansoni	hypothetical protein	0.0073	0.1631	0.1631
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0058	0.101	0.101
Schistosoma mansoni	hypothetical protein	0.0223	0.7697	0.7697
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0073	0.1631	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Schistosoma mansoni	factor for adipocyte differentiation	0.0058	0.101	0.101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0073	0.1631	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1856	0.1856
Schistosoma mansoni	hypothetical protein	0.0058	0.101	0.101
Loa Loa (eye worm)	CAMK protein kinase	0.0073	0.1631	0.1631
Schistosoma mansoni	nephrin	0.0089	0.2266	0.2266
Brugia malayi	hypothetical protein	0.0108	0.3018	0.3018
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0058	0.101	0.101
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0058	0.101	0.1424
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0058	0.101	0.101
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0089	0.2266	0.2266
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0058	0.101	0.101
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0208	0.7092	0.7092
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0073	0.1631	0.1631
Schistosoma mansoni	tripartite motif protein trim9	0.0058	0.101	0.101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106	0.2956	0.2956
Leishmania major	hypothetical protein, conserved	0.0058	0.101	0.1424
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0058	0.101	0.101
Echinococcus granulosus	titin	0.0073	0.1631	0.1631
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0208	0.7092	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0073	0.1631	0.1631
Schistosoma mansoni	factor for adipocyte differentiation	0.0058	0.101	0.101
Brugia malayi	prolyl oligopeptidase family protein	0.0208	0.7092	0.7092
Echinococcus granulosus	cell adhesion molecule	0.0058	0.101	0.101
Echinococcus granulosus	roundabout 2	0.0089	0.2266	0.2266
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0074	0.1644	0.1644
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0073	0.1631	0.1631
Schistosoma mansoni	hemicentin	0.0073	0.1631	0.1631
Schistosoma mansoni	myosin-binding protein-related	0.0073	0.1631	0.1631
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0089	0.2266	0.2266
Schistosoma mansoni	vesicular amine transporter	0.0048	0.06	0.06
Echinococcus granulosus	G1Y162 protein	0.0058	0.101	0.101
Brugia malayi	myotactin form A	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0064	0.1235	0.1235
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0048	0.06	0.06
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0208	0.7092	1
Echinococcus multilocularis	neuroglian	0.0089	0.2266	0.2266
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1856	0.1856
Onchocerca volvulus		0.0058	0.101	0.101
Echinococcus granulosus	Immunoglobulin	0.0048	0.06	0.06
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0073	0.1631	0.1631
Schistosoma mansoni	serine/threonine protein kinase	0.0073	0.1631	0.1631
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0073	0.1631	0.1631
Schistosoma mansoni	factor for adipocyte differentiation	0.0058	0.101	0.101
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0073	0.1631	0.1631
Brugia malayi	Lethal protein 805	0.0058	0.101	0.101
Echinococcus granulosus	nephrin	0.0073	0.1631	0.1631
Echinococcus multilocularis	Fibronectin, type III	0.0058	0.101	0.101
Echinococcus granulosus	defective proboscis extension response	0.0048	0.06	0.06
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0058	0.101	0.101
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0141	0.4364	1
Echinococcus multilocularis	snurportin 1	0.0223	0.7697	0.7697
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0089	0.2266	0.2266
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.01	0.2728	0.2728
Echinococcus multilocularis	Immunoglobulin	0.0048	0.06	0.06
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0089	0.2266	0.2266
Schistosoma mansoni	neuroglian	0.0089	0.2266	0.2266
Echinococcus granulosus	titin	0.0073	0.1631	0.1631
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0089	0.2266	0.2266
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Onchocerca volvulus		0.0073	0.1631	0.1631
Schistosoma mansoni	cell adhesion molecule	0.0089	0.2266	0.2266
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0081	0.1927	0.1927
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0089	0.2266	0.2266
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2266	0.2266
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0058	0.101	0.101
Echinococcus multilocularis	Netrin receptor DCC	0.0058	0.101	0.101
Echinococcus multilocularis	cell adhesion molecule	0.0058	0.101	0.101
Onchocerca volvulus		0.0058	0.101	0.101
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0074	0.1644	0.1644
Echinococcus granulosus	anosmin 1	0.0058	0.101	0.101
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0058	0.101	0.101
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0089	0.2266	0.2266
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0223	0.7697	0.7697
Trypanosoma cruzi	hypothetical protein, conserved	0.0058	0.101	0.1424
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0058	0.101	0.101
Schistosoma mansoni	titin	0.0058	0.101	0.101
Brugia malayi	Fibronectin type III domain containing protein	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0048	0.06	0.06
Echinococcus granulosus	twitchin	0.0063	0.1222	0.1222
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0075	0.1702	0.1702
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0058	0.101	0.101
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0058	0.101	0.101
Echinococcus multilocularis	roundabout 2	0.0137	0.4212	0.4212
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0048	0.06	0.06
Echinococcus granulosus	Netrin receptor DCC	0.0058	0.101	0.101
Echinococcus multilocularis	titin	0.0073	0.1631	0.1631
Loa Loa (eye worm)	hypothetical protein	0.0073	0.1631	0.1631
Echinococcus granulosus	EG95	0.0058	0.101	0.101
Loa Loa (eye worm)	projectin	0.0073	0.1631	0.1631
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0064	0.1235	0.1235
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Echinococcus granulosus	neuroglian	0.0089	0.2266	0.2266
Onchocerca volvulus		0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0058	0.101	0.101
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0058	0.101	0.101
Brugia malayi	Lethal protein 805	0.0058	0.101	0.101
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0075	0.1702	0.1702
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0058	0.101	0.101
Echinococcus granulosus	snurportin 1	0.0223	0.7697	0.7697
Loa Loa (eye worm)	UNCoordinated family member	0.0058	0.101	0.101
Schistosoma mansoni	tyrosine kinase	0.0048	0.0602	0.0602
Echinococcus multilocularis	transfer RNA-Phe	0.0073	0.1631	0.1631
Onchocerca volvulus		0.0058	0.101	0.101
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0074	0.1644	0.1644
Echinococcus granulosus	usherin	0.0058	0.101	0.101
Onchocerca volvulus		0.0058	0.101	0.101
Schistosoma mansoni	titin	0.0073	0.1631	0.1631
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0074	0.1644	0.1644
Echinococcus granulosus	anosmin 1	0.0058	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0048	0.06	0.06
Onchocerca volvulus		0.0058	0.101	0.101
Schistosoma mansoni	cell adhesion molecule	0.0089	0.2266	0.2266
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0058	0.101	0.101
Echinococcus multilocularis	Netrin receptor DCC	0.0058	0.101	0.101
Schistosoma mansoni	nephrin	0.0121	0.3577	0.3577
Brugia malayi	Fibronectin type III domain containing protein	0.0058	0.101	0.101
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0208	0.7092	0.7092
Echinococcus multilocularis	usherin	0.0058	0.101	0.101
Schistosoma mansoni	cell adhesion molecule	0.0122	0.359	0.359
Loa Loa (eye worm)	myotactin form A	0.0058	0.101	0.101
Echinococcus granulosus	neuroglian	0.0063	0.1222	0.1222
Onchocerca volvulus		0.0058	0.101	0.101

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.11 uM	Inhibition of DPP4	ChEMBL.	21320777
IC50 (binding)	= 16 uM	Inhibition of DPP9	ChEMBL.	21320777
IC50 (binding)	> 35 uM	Inhibition of FAP	ChEMBL.	21320777
IC50 (binding)	= 50 uM	Inhibition of DPP8	ChEMBL.	21320777
IC50 (binding)	= 81 uM	Inhibition of QPP	ChEMBL.	21320777

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1683101

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1506683