Detailed information for compound 1549060

Basic information

Technical information
  • TDR Targets ID: 1549060
  • Name: T5587486
  • MW: 366.905 | Formula: C18H23ClN2O2S
  • H donors: 0 H acceptors: 2 LogP: 3.58 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCN(C(C1)c1ccccc1)S(=O)(=O)c1ccc(cc1)C.Cl
  • InChi: 1S/C18H22N2O2S.ClH/c1-15-8-10-17(11-9-15)23(21,22)20-13-12-19(2)14-18(20)16-6-4-3-5-7-16;/h3-11,18H,12-14H2,1-2H3;1H
  • InChiKey: DYWJYUZDIJZPTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0737 1 1
Leishmania major hypothetical protein, conserved 0.0058 0.0564 0.0818
Plasmodium vivax importin-beta 2, putative 0.0035 0.0248 0.3474
Schistosoma mansoni carbonic anhydrase 0.0243 0.3138 0.3083
Mycobacterium ulcerans molybdopterin biosynthesis-like protein MoeZ 0.0058 0.0564 1
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0058 0.0564 0.0564
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0449 0.5995 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0449 0.5995 0.5963
Leishmania major hypothetical protein, conserved 0.0058 0.0564 0.0818
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0737 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0564 0.0564
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0075
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0045
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0026 0.0124 0.0045
Trypanosoma cruzi As/Sb Reductase, putative 0.0058 0.0564 0.0818
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0026 0.0124 0.0145
Leishmania major hypothetical protein, conserved 0.0058 0.0564 0.0818
Entamoeba histolytica hypothetical protein, conserved 0.0058 0.0564 0.0488
Schistosoma mansoni tyrosine kinase 0.0122 0.1456 0.1388
Giardia lamblia Dual specificity phosphatase Cdc25, putative 0.0058 0.0564 1
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0026 0.0124 0.0045
Mycobacterium leprae Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) 0.0058 0.0564 0.5
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.012 0.012
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0026 0.0124 0.0075
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0737 1 1
Entamoeba histolytica hypothetical protein 0.0058 0.0564 0.0488
Schistosoma mansoni ubiquitin-activating enzyme E1C 0.0058 0.0564 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0564 0.0564
Echinococcus granulosus epidermal growth factor receptor 0.0055 0.0534 0.0534
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0026 0.0124 0.0075
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0026 0.0124 0.0075
Trichomonas vaginalis Phage shock protein E precursor, putative 0.0058 0.0564 0.0564
Mycobacterium leprae Conserved hypothetical protein 0.0058 0.0564 0.5
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0026 0.0124 0.0075
Entamoeba histolytica rodhanase-like domain containing protein 0.0737 1 1
Leishmania major hypothetical protein, unknown function 0.0058 0.0564 0.0818
Mycobacterium tuberculosis Possible transcriptional regulatory protein (possibly ArsR-family) 0.0058 0.0564 1
Schistosoma mansoni hypothetical protein 0.0058 0.0564 0.0488
Echinococcus multilocularis tRNA 2 selenouridine synthase 0.0058 0.0564 0.0564
Chlamydia trachomatis hypothetical protein 0.0058 0.0564 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0687 0.0687
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.008 0.008
Schistosoma mansoni carbonic anhydrase-related 0.0243 0.3138 0.3083
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Brugia malayi RNA, U transporter 1 0.0099 0.1139 0.1068
Echinococcus granulosus carbonic anhydrase II 0.0449 0.5995 0.5995
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.012 0.0132
Trichomonas vaginalis thiosulfate sulfertansferase, putative 0.0058 0.0564 0.0564
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.0058 0.0564 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0737 1 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0075
Plasmodium vivax rhodanese like protein, putative 0.0058 0.0564 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0122 0.1456 0.1456
Loa Loa (eye worm) hypothetical protein 0.0058 0.0564 0.0564
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0737 1 1
Echinococcus granulosus carbonic anhydrase 0.0243 0.3138 0.3138
Echinococcus multilocularis insulin receptor 0.0122 0.1456 0.1456
Giardia lamblia Hypothetical protein 0.0058 0.0564 1
Schistosoma mansoni tyrosine kinase 0.0054 0.052 0.0444
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0737 1 1
Schistosoma mansoni ubiquitin-activating enzyme E1 0.0058 0.0564 0.0488
Trichomonas vaginalis Phage shock protein E precursor, putative 0.0058 0.0564 0.0564
Trichomonas vaginalis cdc25a, putative 0.0058 0.0564 0.0564
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0243 0.3138 0.3083
Leishmania major importin beta-1 subunit, putative 0.0028 0.0156 0.013
Mycobacterium ulcerans thiosulfate sulfurtransferase SseA 0.0058 0.0564 1
Echinococcus granulosus snurportin 1 0.0372 0.4927 0.4927
Echinococcus granulosus insulin receptor 0.0122 0.1456 0.1456
Echinococcus multilocularis carbonic anhydrase 0.0243 0.3138 0.3138
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0248 0.0284
Echinococcus multilocularis epidermal growth factor receptor 0.0055 0.0534 0.0534
Echinococcus multilocularis heat shock protein 67b2 0.0058 0.0564 0.0564
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0156 0.0156
Trypanosoma brucei carbonic anhydrase-like protein 0.0449 0.5995 1
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0026 0.0124 0.0124
Brugia malayi Protein kinase domain containing protein 0.0067 0.07 0.0626
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0737 1 1
Entamoeba histolytica rodhanase-like domain containing protein 0.0737 1 1
Trypanosoma brucei mercaptopyruvate sulfurtransferase, putative 0.0058 0.0564 0.0818
Echinococcus multilocularis Rhodanese 0.0058 0.0564 0.0564
Entamoeba histolytica rodhanase-like domain containing protein 0.0058 0.0564 0.0488
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Echinococcus granulosus carbonic anhydrase 0.0243 0.3138 0.3138
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0058 0.0564 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0564 0.0564
Schistosoma mansoni tyrosine kinase 0.0054 0.052 0.0444
Trichomonas vaginalis cdc25c, putative 0.0737 1 1
Schistosoma mansoni ran 0.0026 0.012 0.0041
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0018 0.0013 0.0013
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0564 0.0818
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0248 0.0248
Entamoeba histolytica hypothetical protein 0.0028 0.0156 0.0077
Schistosoma mansoni tyrosine kinase 0.0055 0.0534 0.0458
Toxoplasma gondii rhodanese family domain-containing protein 0.0058 0.0564 0.1583
Giardia lamblia Thiosulfate sulfurtransferase 0.0058 0.0564 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0124
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0156 0.0156
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0449 0.5995 0.5963
Echinococcus multilocularis carbonic anhydrase II 0.0449 0.5995 0.5995
Schistosoma mansoni hypothetical protein 0.0058 0.0564 0.0488
Echinococcus multilocularis centrosomal protein of 41 kDa 0.0058 0.0564 0.0564
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0045
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0026 0.0124 0.0045
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0026 0.0124 0.0918
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0026 0.0124 0.0045
Loa Loa (eye worm) hypothetical protein 0.0058 0.0564 0.0564
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0058 0.0564 0.0564
Schistosoma mansoni carbonic anhydrase-related 0.0243 0.3138 0.3083
Schistosoma mansoni ran 0.0026 0.012 0.0041
Entamoeba histolytica Ran family GTPase 0.0026 0.012 0.0041
Toxoplasma gondii hypothetical protein 0.0243 0.3138 1
Schistosoma mansoni hypothetical protein 0.0372 0.4927 0.4886
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.008 0.008
Schistosoma mansoni tyrosine kinase 0.0055 0.0534 0.0458
Plasmodium falciparum importin beta, putative 0.0035 0.0248 0.055
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.008 0.008
Leishmania major hypothetical protein, conserved 0.0058 0.0564 0.0818
Loa Loa (eye worm) hypothetical protein 0.0058 0.0564 0.0564
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0124
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0243 0.3138 0.3138
Giardia lamblia Hypothetical protein 0.0058 0.0564 1
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0026 0.0124 0.0145
Loa Loa (eye worm) hypothetical protein 0.0243 0.3138 0.3138
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0248 0.0284
Entamoeba histolytica rodhanase-like domain containing protein 0.0058 0.0564 0.0488
Mycobacterium leprae PROBABLE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOEB1 (MPT-SYNTHASE SULFURYLASE) (MOLYBDOPTERIN SYNTHASE SULPHURYLASE) 0.0058 0.0564 0.5
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran 0.0058 0.0564 1
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Schistosoma mansoni hypothetical protein 0.0243 0.3138 0.3083
Leishmania major GTP-binding protein, putative 0.0026 0.012 0.0068
Entamoeba histolytica hypothetical protein 0.0058 0.0564 0.0488
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0026 0.0124 0.0075
Leishmania major 3-mercaptopyruvate sulfurtransferase 0.0058 0.0564 0.0818
Echinococcus multilocularis carbonic anhydrase 0.0243 0.3138 0.3138
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0737 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0058 0.0564 0.0488
Brugia malayi Importin beta-1 subunit 0.0035 0.0248 0.017
Plasmodium falciparum carbonic anhydrase 0.0243 0.3138 1
Brugia malayi Furin-like cysteine rich region family protein 0.0055 0.0534 0.0458
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase SseB 0.0058 0.0564 1
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Loa Loa (eye worm) hypothetical protein 0.0679 0.9201 0.9201
Loa Loa (eye worm) hypothetical protein 0.0737 1 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.3138 0.3138
Brugia malayi RIKEN cDNA 4930451A13 0.0058 0.0564 0.0488
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0026 0.0124 0.0145
Treponema pallidum glyceraldehyde 3-phosphate dehydrogenase (gap) 0.0026 0.0124 1
Trypanosoma brucei rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.012 0.0837
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0918
Brugia malayi Rhodanese-like domain containing protein 0.0058 0.0564 0.0488
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) 0.0058 0.0564 1
Schistosoma mansoni hypothetical protein 0.0058 0.0564 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0564 0.0564
Brugia malayi MoeZ/MoeB domain containing protein 0.0058 0.0564 0.0488
Trichomonas vaginalis ran, putative 0.0026 0.012 0.012
Brugia malayi Rhodanese-like domain containing protein 0.0058 0.0564 0.0488
Mycobacterium tuberculosis Probable thiosulfate sulfurtransferase CysA3 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran 0.0058 0.0564 1
Schistosoma mansoni importin beta-1 0.0035 0.0248 0.017
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0737 1 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0075
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0156 0.013
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0026 0.0124 0.0075
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0449 0.5995 0.5995
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0055 0.0534 0.0534
Brugia malayi Rhodanese-like domain containing protein 0.0737 1 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0679 0.9201 0.9201
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0026 0.0124 0.0124
Echinococcus granulosus heat shock protein 67b2 0.0058 0.0564 0.0564
Echinococcus granulosus epidermal growth factor receptor 0.0055 0.0534 0.0534
Loa Loa (eye worm) TK/EGFR protein kinase 0.0055 0.0534 0.0534
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0156 0.0156
Leishmania major hypothetical protein, conserved 0.0058 0.0564 0.0818
Echinococcus granulosus carbonic anhydrase 0.0243 0.3138 0.3138
Trichomonas vaginalis cdc25b, putative 0.0737 1 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0122 0.1456 0.1456
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0045
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.012 0.0041
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0026 0.0124 0.0075
Loa Loa (eye worm) TK/INSR protein kinase 0.0122 0.1456 0.1456
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0243 0.3138 0.3083
Echinococcus multilocularis epidermal growth factor receptor 0.0055 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0035 0.0248 0.0248
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Schistosoma mansoni hypothetical protein 0.0058 0.0564 0.0488
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0449 0.5995 1
Mycobacterium ulcerans hypothetical protein 0.0058 0.0564 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0124
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0058 0.0564 0.0564
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.012 0.012
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0449 0.5995 0.5963
Schistosoma mansoni tyrosine kinase 0.0055 0.0534 0.0458
Mycobacterium ulcerans thiosulfate sulfurtransferase, CysA2 0.0058 0.0564 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0243 0.3138 0.3083
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0026 0.0124 0.0124
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.012 0.0068
Entamoeba histolytica hypothetical protein 0.0058 0.0564 0.0488
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0564 0.0564
Onchocerca volvulus 0.0737 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0243 0.3138 0.3083
Leishmania major As/Sb Reductase 0.0058 0.0564 0.0818
Echinococcus granulosus importin subunit beta 1 0.0035 0.0248 0.0248
Onchocerca volvulus 0.0737 1 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.012 0.0837
Schistosoma mansoni tyrosine kinase 0.0122 0.1456 0.1388
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0026 0.012 0.0068
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0026 0.0124 0.0075
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.012 0.012
Trichomonas vaginalis cdc25c, putative 0.0058 0.0564 0.0564
Wolbachia endosymbiont of Brugia malayi sulfurtransferase 0.0058 0.0564 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.008 0.008
Trypanosoma cruzi mercaptopyruvate sulfurtransferase, putative 0.0058 0.0564 0.0818
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0026 0.0124 0.0124
Mycobacterium tuberculosis Probable molybdenum cofactor biosynthesis protein MoeB2 (MPT-synthase sulfurylase) (molybdopterin synthase sulphurylase) 0.0058 0.0564 1
Echinococcus granulosus Rhodanese 0.0058 0.0564 0.0564
Schistosoma mansoni Centrosomal protein of 41 kDa (Cep41 protein) (Testis-specificprotein A14 protein) 0.0058 0.0564 0.0488
Loa Loa (eye worm) hypothetical protein 0.0243 0.3138 0.3138
Leishmania major carbonic anhydrase-like protein 0.0449 0.5995 1
Plasmodium falciparum mitogen-activated protein kinase phosphatase 1, putative 0.0058 0.0564 0.1583
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0026 0.0124 0.0124
Entamoeba histolytica hypothetical protein 0.0058 0.0564 0.0488
Mycobacterium leprae PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRAN 0.0058 0.0564 0.5
Schistosoma mansoni dual specificity protein phosphatase 0.0058 0.0564 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0564 0.0564
Echinococcus granulosus centrosomal protein of 41 kDa 0.0058 0.0564 0.0564
Loa Loa (eye worm) thiosulfate sulfurtransferase 0.0058 0.0564 0.0564
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0026 0.0124 0.0045
Schistosoma mansoni carbonic anhydrase-related 0.0243 0.3138 0.3083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0564 1
Entamoeba histolytica rodhanase-like domain containing protein 0.0737 1 1
Plasmodium falciparum rhodanese like protein, putative 0.0058 0.0564 0.1583
Trichomonas vaginalis cdc25b, putative 0.0737 1 1
Echinococcus multilocularis carbonic anhydrase 0.0243 0.3138 0.3138
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0026 0.0124 0.0918
Loa Loa (eye worm) carbonic anhydrase 3 0.0449 0.5995 0.5995
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.012 0.0068
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Schistosoma mansoni tyrosine kinase 0.0054 0.052 0.0444
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0449 0.5995 0.5963
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0248 0.055
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0737 1 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0243 0.3138 0.3083
Brugia malayi Protein kinase domain containing protein 0.0122 0.1456 0.1388
Echinococcus granulosus 5'partial|tRNA 2 selenouridine synthase 0.0058 0.0564 0.0564
Entamoeba histolytica rodhanase-like domain containing protein 0.0058 0.0564 0.0488
Mycobacterium tuberculosis Conserved protein 0.0058 0.0564 1
Brugia malayi Thiosulfate sulfurtransferase D2023.5 0.0058 0.0564 0.0488
Trypanosoma cruzi rhodanese-like domain containing protein, putative 0.0058 0.0564 0.0818
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.012 0.0132
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4927 0.4927
Trypanosoma cruzi As/Sb Reductase, putative 0.0058 0.0564 0.0818
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0018 0.0013 0.0013
Mycobacterium ulcerans glyceraldehyde 3-phosphate dehydrogenase Gap 0.0026 0.0124 0.0918
Leishmania major hypothetical protein, conserved 0.0058 0.0564 0.0818
Echinococcus multilocularis snurportin 1 0.0372 0.4927 0.4927
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0564 0.0818
Onchocerca volvulus 0.0737 1 1
Plasmodium vivax mitogen-activated protein kinase phosphatase 1, putative 0.0058 0.0564 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.4654 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.0621 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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