Detailed information for compound 1550368

Basic information

Technical information
  • TDR Targets ID: 1550368
  • Name: N-[[1-[(1-ethylpyrazol-4-yl)methyl]piperidin- 3-yl]methyl]quinoline-8-sulfonamide
  • MW: 413.536 | Formula: C21H27N5O2S
  • H donors: 1 H acceptors: 4 LogP: 2.04 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1ncc(c1)CN1CCCC(C1)CNS(=O)(=O)c1cccc2c1nccc2
  • InChi: 1S/C21H27N5O2S/c1-2-26-16-18(12-23-26)15-25-11-5-6-17(14-25)13-24-29(27,28)20-9-3-7-19-8-4-10-22-21(19)20/h3-4,7-10,12,16-17,24H,2,5-6,11,13-15H2,1H3
  • InChiKey: PORQYVPYFBHFFW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[1-[(1-ethylpyrazol-4-yl)methyl]-3-piperidyl]methyl]quinoline-8-sulfonamide
  • N-[[1-[(1-ethyl-4-pyrazolyl)methyl]-3-piperidinyl]methyl]-8-quinolinesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0064 0.037 0.0751
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0208 0.0341
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0219 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0124 0.5
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0075 0.0448 0.1214
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.022 0.0607
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0124 0.4913
Echinococcus granulosus zinc finger protein 0.0023 0.0068 0.0347
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0138 0.0918 0.2515
Onchocerca volvulus 0.0138 0.0918 0.2311
Loa Loa (eye worm) hypothetical protein 0.0278 0.1945 0.5357
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0075 0.0448 0.1238
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0106 0.0265
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0138 0.0918 0.2535
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0219 0.036
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0138 0.0918 0.1507
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1373 1 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Toxoplasma gondii ABC1 family protein 0.0043 0.0219 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0138 0.0918 0.4722
Loa Loa (eye worm) hypothetical protein 0.0075 0.0448 0.1214
Schistosoma mansoni survival motor neuron protein 0.005 0.0268 0.074
Onchocerca volvulus 0.0075 0.0448 0.0975
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0249 0.0687
Loa Loa (eye worm) hypothetical protein 0.0075 0.0448 0.1214
Echinococcus multilocularis survival motor neuron protein 1 0.0245 0.1706 0.2799
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0138 0.0918 0.2535
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0506 0.3623 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0138 0.0918 0.2515
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0219 1
Echinococcus multilocularis lamin 0.0028 0.0106 0.0173
Brugia malayi intermediate filament protein 0.0028 0.0106 0.0265
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0093 0.0153
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0208 0.1069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0249 0.0687
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0046 0.0127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0249 0.0409
Loa Loa (eye worm) hypothetical protein 0.0075 0.0448 0.1214
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0219 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0208 0.1071
Brugia malayi beta-lactamase family protein 0.0043 0.0219 0.058
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.004 0.0193 0.0507
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0064 0.037 0.0995
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0138 0.0918 0.2515
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0278 0.1945 1
Loa Loa (eye worm) ACC-1 protein 0.0138 0.0918 0.2515
Brugia malayi hypothetical protein 0.0064 0.037 0.0995
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0219 1
Onchocerca volvulus 0.005 0.0268 0.0462
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0124 0.4913
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0138 0.0918 0.2515
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.037 0.0995
Echinococcus granulosus glycine receptor subunit alpha 1 0.0138 0.0918 0.4722
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.004 0.0193 0.0507
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0138 0.0918 0.1507
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0064 0.037 0.0995
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.058
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.037 0.102
Schistosoma mansoni hypothetical protein 0.0042 0.0208 0.0575
Schistosoma mansoni nAChR subunit 0.0064 0.037 0.102
Schistosoma mansoni nAChR subunit 0.0138 0.0918 0.2535
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0278 0.1945 0.5357
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0138 0.0918 0.2535
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0448 0.1214
Loa Loa (eye worm) hypothetical protein 0.0075 0.0448 0.1214
Schistosoma mansoni acetylcholine receptor subunit beta 0.0064 0.037 0.102
Loa Loa (eye worm) hypothetical protein 0.005 0.0266 0.0708
Brugia malayi beta-lactamase 0.0043 0.0219 0.058
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0208 0.0342
Schistosoma mansoni nAChR subunit 0.0138 0.0918 0.2535
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0046 0.0127
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.037 0.0995
Loa Loa (eye worm) ACC-1 protein 0.0138 0.0918 0.2515
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0064 0.037 0.0995
Onchocerca volvulus 0.0064 0.037 0.0751
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0918 0.2515
Loa Loa (eye worm) hypothetical protein 0.0045 0.0229 0.0606
Brugia malayi Cation transporter family protein 0.0138 0.0918 0.2515
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0138 0.0918 0.2515
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0278 0.1945 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0506 0.3623 1
Trichomonas vaginalis esterase, putative 0.0043 0.0219 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.037 0.102
Brugia malayi hypothetical protein 0.0064 0.037 0.0995
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0046 0.0236
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0219 0.1128
Loa Loa (eye worm) hypothetical protein 0.0442 0.3153 0.8699
Echinococcus multilocularis glycine receptor subunit beta 0.0138 0.0918 0.1507
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.058
Brugia malayi Cation transporter family protein 0.0506 0.3623 1
Schistosoma mansoni nAChR subunit 0.0138 0.0918 0.2535
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1373 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0138 0.0918 0.4722
Loa Loa (eye worm) hypothetical protein 0.0048 0.0249 0.0662
Brugia malayi Bromodomain containing protein 0.0045 0.0228 0.0605
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0077 0.0185
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0315
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0046 0.0075
Schistosoma mansoni hypothetical protein 0.0018 0.0031 0.0085
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.037 0.19
Loa Loa (eye worm) LGC-31 protein 0.0138 0.0918 0.2515
Onchocerca volvulus 0.0138 0.0918 0.2311
Loa Loa (eye worm) hypothetical protein 0.0075 0.0448 0.1214
Echinococcus granulosus nAChR subunit 0.0075 0.0448 0.2305
Brugia malayi PHD-finger family protein 0.0029 0.0113 0.0286
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Schistosoma mansoni nAChR subunit 0.0138 0.0918 0.2535
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0278 0.1945 0.3192
Schistosoma mansoni bromodomain containing protein 0.0074 0.0443 0.1222
Schistosoma mansoni lamin 0.0028 0.0106 0.0291
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0138 0.0918 0.4722
Echinococcus granulosus glycine receptor subunit beta 0.0138 0.0918 0.4722
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0249 0.0662
Brugia malayi Bromodomain containing protein 0.0087 0.0543 0.1477
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0278 0.1945 0.3192
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0138 0.0918 0.2515
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0046 0.0127
Schistosoma mansoni hypothetical protein 0.0024 0.0077 0.0212
Schistosoma mansoni zinc finger protein 0.0023 0.0068 0.0187
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0219 1
Mycobacterium ulcerans transcriptional regulator 0.1373 1 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.104 0.2853
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.058
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0106 0.0265
Loa Loa (eye worm) hypothetical protein 0.0155 0.104 0.2853
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0051 0.0114
Schistosoma mansoni nAChR subunit 0.0138 0.0918 0.2535
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0219 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0046 0.0075
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0138 0.0918 0.1507
Onchocerca volvulus 0.0043 0.0219 0.0324
Schistosoma mansoni voltage-gated potassium channel 0.0044 0.022 0.0607
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0138 0.0918 0.2515
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0138 0.0918 0.2515
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0918 0.2515
Leishmania major hypothetical protein, conserved 0.0043 0.0219 1
Onchocerca volvulus 0.0506 0.3623 1
Brugia malayi Muscleblind-like protein 0.0155 0.104 0.2853
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0138 0.0918 0.4722
Brugia malayi beta-lactamase family protein 0.0043 0.0219 0.058
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0075 0.0448 0.1214
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0138 0.0918 0.1507
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0138 0.0918 0.2515
Onchocerca volvulus 0.0138 0.0918 0.2311
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0138 0.0918 0.2515
Loa Loa (eye worm) hypothetical protein 0.0082 0.0507 0.1375
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.037 0.0606
Echinococcus multilocularis zinc finger protein 0.0023 0.0068 0.0111
Echinococcus granulosus muscleblind protein 0.0155 0.104 0.5349
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0219 1
Loa Loa (eye worm) hypothetical protein 0.0506 0.3623 1
Mycobacterium ulcerans TetR family transcriptional regulator 0.1373 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.058
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0448 0.1214
Loa Loa (eye worm) hypothetical protein 0.0075 0.0448 0.1214
Loa Loa (eye worm) hypothetical protein 0.0506 0.3623 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0138 0.0918 0.2535
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Echinococcus granulosus intermediate filament protein 0.0028 0.0106 0.0542
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0219 0.0606
Brugia malayi excitatory GABA receptor EXP-1A 0.0138 0.0918 0.2515
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0046 0.0127
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0278 0.1945 0.5357
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0138 0.0918 0.1507
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0219 0.058
Onchocerca volvulus Putative nachr subunit 0.0278 0.1945 0.523
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0412 0.2118
Brugia malayi hypothetical protein 0.0064 0.037 0.0995
Leishmania major hypothetical protein, conserved 0.003 0.0124 0.4913
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0918 0.2515
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0278 0.1945 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0138 0.0918 0.4722
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0412 0.0676
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Brugia malayi hypothetical protein 0.0245 0.1706 0.4694
Echinococcus granulosus potassium voltage gated channel subfamily H 0.004 0.0193 0.0992
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0093 0.0257
Loa Loa (eye worm) hypothetical protein 0.002 0.0046 0.01
Loa Loa (eye worm) hypothetical protein 0.0245 0.1706 0.4694
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0046 0.0236
Onchocerca volvulus 0.0043 0.0219 0.0324
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0124 0.4913
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0278 0.1945 0.3192
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0064 0.037 0.0606
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0918 0.2515
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Onchocerca volvulus 0.0043 0.0219 0.0324
Echinococcus granulosus glycine receptor subunit beta 0.0138 0.0918 0.4722
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0249 0.128
Echinococcus multilocularis musashi 0.0028 0.0106 0.0173
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Schistosoma mansoni intermediate filament proteins 0.0028 0.0106 0.0291
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0219 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Echinococcus granulosus lamin dm0 0.0028 0.0106 0.0542
Brugia malayi follicle stimulating hormone receptor 0.024 0.1669 0.4591
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Loa Loa (eye worm) acetylcholine receptor protein 0.0064 0.037 0.0995
Echinococcus multilocularis lamin dm0 0.0028 0.0106 0.0173
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0138 0.0918 0.4722
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0138 0.0918 0.2515
Loa Loa (eye worm) hypothetical protein 0.0035 0.0154 0.04
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.037 0.0995
Brugia malayi hypothetical protein 0.003 0.0124 0.0315
Loa Loa (eye worm) GABA receptor subunit 0.0075 0.0448 0.1214
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Entamoeba histolytica hypothetical protein 0.0075 0.0448 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0249 0.0662
Schistosoma mansoni nAChR subunit 0.0138 0.0918 0.2535
Echinococcus multilocularis glycine receptor subunit beta 0.0138 0.0918 0.1507
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0138 0.0918 0.2515
Schistosoma mansoni zinc finger protein 0.0018 0.0031 0.0085
Brugia malayi hypothetical protein 0.0042 0.0208 0.0549
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1944 0.1763
Schistosoma mansoni neurotransmitter gated ion channel 0.0075 0.0448 0.1238
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0138 0.0918 0.1507
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0918 0.2515
Echinococcus multilocularis muscleblind protein 1 0.0155 0.104 0.1708
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0219 1
Echinococcus multilocularis nAChR subunit 0.0075 0.0448 0.0736
Echinococcus granulosus nAChR subunit 0.0138 0.0918 0.4722
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0138 0.0918 0.4722
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0093 0.0478
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0254
Loa Loa (eye worm) hypothetical protein 0.0075 0.0448 0.1214
Onchocerca volvulus 0.0506 0.3623 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0138 0.0918 0.2515
Echinococcus multilocularis muscleblind protein 0.0155 0.104 0.1708
Loa Loa (eye worm) hypothetical protein 0.0028 0.0106 0.0265
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.004 0.0193 0.0317
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0249 0.0409
Schistosoma mansoni nAChR subunit 0.0138 0.0918 0.2535
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0268 0.0714
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.037 0.0995
Echinococcus multilocularis nAChR subunit 0.0138 0.0918 0.1507
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0124 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0138 0.0918 0.2515
Schistosoma mansoni lamin 0.0028 0.0106 0.0291
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0075 0.0448 0.1238
Loa Loa (eye worm) beta-lactamase 0.0043 0.0219 0.058
Loa Loa (eye worm) hypothetical protein 0.0043 0.0219 0.058
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Schistosoma mansoni hypothetical protein 0.005 0.0268 0.074
Schistosoma mansoni nAChR subunit 0.0064 0.037 0.102
Onchocerca volvulus 0.0064 0.037 0.0751
Onchocerca volvulus 0.0506 0.3623 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0219 0.058
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0208 0.0575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0249 0.0687
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0842 0.6093 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Brugia malayi hypothetical protein 0.0064 0.037 0.0995
Echinococcus granulosus lamin 0.0028 0.0106 0.0542
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0106 0.0265
Loa Loa (eye worm) hypothetical protein 0.0075 0.0448 0.1214
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.1669 0.4591
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0219 0.0606
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0064 0.037 0.0606
Brugia malayi hypothetical protein 0.0064 0.037 0.0995
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0064 0.037 0.19
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0064 0.037 0.0995
Brugia malayi hypothetical protein 0.002 0.0044 0.0095
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Echinococcus granulosus survival motor neuron protein 1 0.0245 0.1706 0.8769
Brugia malayi Cation transporter family protein 0.0138 0.0918 0.2515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0249 0.128
Onchocerca volvulus 0.0075 0.0448 0.0975
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0138 0.0918 0.2515
Loa Loa (eye worm) hypothetical protein 0.0064 0.037 0.0995
Loa Loa (eye worm) hypothetical protein 0.0138 0.0918 0.2515
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0138 0.0918 0.1507
Schistosoma mansoni acetylcholine receptor-related 0.0064 0.037 0.102

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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