Detailed information for compound 1550856

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 896.122 | Formula: C51H69N5O9
  • H donors: 5 H acceptors: 6 LogP: 5.97 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC[C@@H]([C@@H](C(=O)OC)NC(=O)[C@@]1(O)[C@H](O)[C@]2(CC)C=CCN3[C@@H]2[C@@]2([C@@]1(C)N(C)c1c2cc(c(c1)OC)[C@]1(C[C@H]2CN(CCc4c1[nH]c1c4cccc1)C[C@](C2)(O)CC)C(=O)OC)CC3)C
  • InChi: 1S/C51H69N5O9/c1-10-30(4)39(41(57)64-8)53-44(59)51(62)43(58)48(12-3)19-15-21-56-23-20-50(42(48)56)34-24-35(38(63-7)25-37(34)54(6)46(50,51)5)49(45(60)65-9)27-31-26-47(61,11-2)29-55(28-31)22-18-33-32-16-13-14-17-36(32)52-40(33)49/h13-17,19,24-25,30-31,39,42-43,52,58,61-62H,10-12,18,20-23,26-29H2,1-9H3,(H,53,59)/t30-,31-,39-,42-,43+,46+,47-,48+,49-,50+,51-/m0/s1
  • InChiKey: LWLYAINNZOAUPM-GGKUUYBASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.1133 0.2313
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0029 0.0384 0.0784
Schistosoma mansoni hypothetical protein 0.0028 0.0369 0.0624
Brugia malayi RNase H family protein 0.0043 0.0679 0.2192
Brugia malayi Protein kinase domain containing protein 0.0037 0.0551 0.178
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0065 0.1133 0.2313
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0028 0.0369 0.0754
Brugia malayi Tyrosine-protein kinase abl-1 0.0065 0.1133 0.3657
Brugia malayi SH2 domain containing protein 0.0029 0.0384 0.124
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0794 0.2564
Echinococcus multilocularis NCK adaptor protein 0.0057 0.0965 0.1971
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Brugia malayi SH2 domain containing protein 0.0037 0.0551 0.178
Schistosoma mansoni shc transforming protein 0.0029 0.0384 0.0649
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Brugia malayi beta-lactamase family protein 0.0036 0.0535 0.1726
Echinococcus multilocularis tyrosine kinase 0.0037 0.0551 0.1126
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0291 0.011
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0055 0.0922 0.0753
Echinococcus multilocularis signal transduction protein lnk realted 0.0029 0.0384 0.0784
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.4558 1
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0029 0.0384 0.124
Echinococcus granulosus SHC transforming protein 3 0.0029 0.0384 0.0784
Echinococcus multilocularis endophilin A3 0.0028 0.0369 0.0754
Brugia malayi STAT protein, DNA binding domain containing protein 0.0029 0.0384 0.124
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0369 0.019
Echinococcus granulosus c src tyrosine kinase 0.0065 0.1133 0.2313
Echinococcus multilocularis cpg binding protein 0.003 0.0418 0.0853
Schistosoma mansoni cpg binding protein 0.003 0.0418 0.0706
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.1133 0.2313
Entamoeba histolytica SH2 domain containing protein 0.0029 0.0384 0.0205
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0029 0.0384 0.0205
Echinococcus multilocularis tyrosine protein kinase shark 0.0037 0.0551 0.1126
Echinococcus granulosus SH2 domain containing adapter protein F 0.0029 0.0384 0.0784
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0679 0.0506
Echinococcus granulosus glycogen phosphorylase 0.0107 0.1987 0.4058
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0029 0.0384 0.0784
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0535 0.0359
Treponema pallidum ribonuclease H (rnhA) 0.0043 0.0679 0.1991
Echinococcus granulosus tyrosine protein kinase Srms 0.0037 0.0551 0.1126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0711 0.1202
Brugia malayi thymidylate kinase 0.014 0.2676 0.8641
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Loa Loa (eye worm) hypothetical protein 0.0036 0.0535 0.1726
Brugia malayi SH2 domain containing protein 0.0029 0.0384 0.124
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0182 0.0589
Schistosoma mansoni SH2A 0.0029 0.0384 0.0649
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.016 0.3097 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0057 0.0965 0.3117
Entamoeba histolytica protein kinase, putative 0.0029 0.0384 0.0205
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0057 0.0965 0.1632
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0525 0.1174
Schistosoma mansoni tensin-related 0.0029 0.0384 0.0649
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Leishmania major thymidine kinase, putative 0.0495 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0369 0.019
Echinococcus multilocularis thymidine kinase 0.0247 0.4896 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0369 0.019
Schistosoma mansoni tyrosine kinase 0.0065 0.1133 0.1915
Brugia malayi beta-lactamase family protein 0.0036 0.0535 0.1726
Trypanosoma brucei hypothetical protein, conserved 0.005 0.0818 0.0647
Schistosoma mansoni hypothetical protein 0.0015 0.0106 0.018
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0535 0.0805
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0028 0.0369 0.0624
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0106 0.0343
Brugia malayi SH2 domain containing protein 0.0029 0.0384 0.124
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0535 0.0805
Schistosoma mansoni inositol monophosphatase 0.0036 0.0525 0.0887
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0065 0.1133 0.2313
Loa Loa (eye worm) hypothetical protein 0.0024 0.0291 0.0939
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.016 0.3097 0.6661
Brugia malayi SH3 domain containing protein 0.0028 0.0369 0.1192
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0525 0.1372
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0029 0.0384 0.124
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0037 0.0551 0.1126
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0369 0.1192
Brugia malayi SH2 domain containing protein 0.0029 0.0384 0.124
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.1987 0.4058
Entamoeba histolytica Thymidylate kinase, putative 0.014 0.2676 0.254
Schistosoma mansoni thyroid hormone receptor 0.0138 0.264 0.4464
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0029 0.0384 0.124
Schistosoma mansoni thymidylate kinase 0.014 0.2676 0.4525
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0916 0.2518
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0525 0.1072
Entamoeba histolytica hypothetical protein 0.0028 0.0369 0.019
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0028 0.0369 0.0754
Brugia malayi hypothetical protein 0.0037 0.0551 0.178
Brugia malayi beta-lactamase 0.0036 0.0535 0.1726
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.1192
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0028 0.0369 0.0754
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.016 0.3097 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0384 0.1238
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0525 0.0349
Mycobacterium ulcerans hypothetical protein 0.0036 0.0535 0.1208
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0065 0.1133 0.2313
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0369 0.019
Loa Loa (eye worm) p53BP2 0.0028 0.0369 0.1192
Schistosoma mansoni tyrosine kinase 0.0065 0.1133 0.1915
Schistosoma mansoni tyrosine kinase 0.0065 0.1133 0.1915
Trichomonas vaginalis thymidine kinase, putative 0.0495 1 1
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0028 0.0369 0.019
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.1987 0.1838
Mycobacterium tuberculosis Conserved protein 0.0036 0.0535 0.0805
Echinococcus granulosus hypothetical protein 0.0029 0.0384 0.0784
Schistosoma mansoni glycogen phosphorylase 0.0046 0.0739 0.1249
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0065 0.1133 0.2313
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0065 0.1133 0.2313
Onchocerca volvulus 0.0029 0.0384 0.124
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0065 0.1133 0.1915
Leishmania major hypothetical protein, conserved 0.0036 0.0535 0.0359
Schistosoma mansoni hypothetical protein 0.0011 0.0014 0.0023
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0128 0.2428 0.496
Echinococcus multilocularis intersectin 2 0.0028 0.0369 0.0754
Echinococcus multilocularis GPCR, family 2 0.0015 0.0106 0.0217
Echinococcus multilocularis SH2 domain containing protein 7 0.0029 0.0384 0.0784
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0369 0.019
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0535 0.0359
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0291 0.011
Brugia malayi hypothetical protein 0.0029 0.0384 0.124
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0369 0.1192
Loa Loa (eye worm) hypothetical protein 0.0033 0.0476 0.1536
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0525 0.0349
Brugia malayi Protein kinase domain containing protein 0.0037 0.0551 0.178
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0384 0.124
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0182 0.0589
Loa Loa (eye worm) hypothetical protein 0.0037 0.0551 0.178
Onchocerca volvulus Putative cortactin 0.0028 0.0369 0.1192
Trypanosoma brucei ribonuclease H1 0.0043 0.0679 0.0506
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.1192
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.016 0.3097 0.2969
Schistosoma mansoni thymidylate kinase 0.014 0.2676 0.4525
Onchocerca volvulus Glycogen phosphorylase homolog 0.0107 0.1987 0.6415
Onchocerca volvulus 0.0029 0.0384 0.124
Loa Loa (eye worm) hypothetical protein 0.0036 0.0535 0.1726
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0065 0.1133 0.2313
Loa Loa (eye worm) hypothetical protein 0.0036 0.0535 0.1726
Echinococcus multilocularis tensin 0.0029 0.0384 0.0784
Loa Loa (eye worm) inositol-1 0.0036 0.0525 0.1694
Loa Loa (eye worm) hypothetical protein 0.0049 0.0794 0.2564
Entamoeba histolytica hypothetical protein 0.0028 0.0369 0.019
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0028 0.0369 0.1192
Schistosoma mansoni hypothetical protein 0.0053 0.0873 0.1476
Schistosoma mansoni tensin-related 0.0029 0.0384 0.0649
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0028 0.0369 0.019
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0447 0.0606
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0535 0.0805
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.005 0.0818 0.0647
Schistosoma mansoni nck2/grb4 0.0057 0.0965 0.1632
Brugia malayi tRNA modification GTPase TrmE family protein 0.0029 0.0384 0.124
Echinococcus multilocularis SH2 motif 0.0029 0.0384 0.0784
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0476 0.1536
Mycobacterium leprae Probable lipase LipE 0.0036 0.0535 0.0329
Echinococcus granulosus fch and double sh3 domains protein 2 0.0028 0.0369 0.0754
Trichomonas vaginalis p67phox protein, putative 0.0028 0.0369 0.019
Echinococcus multilocularis SHC transforming protein 3 0.0029 0.0384 0.0784
Schistosoma mansoni dreadlocks/dock 0.0028 0.0369 0.0624
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0291 0.0372
Onchocerca volvulus 0.0037 0.0551 0.178
Brugia malayi Inositol-1 0.0036 0.0525 0.1694
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0076 0.1362 0.1202
Onchocerca volvulus 0.0037 0.0551 0.178
Echinococcus granulosus ribonuclease H1 0.0043 0.0679 0.1387
Brugia malayi SH2 domain containing protein 0.0029 0.0384 0.124
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.1133 0.2313
Echinococcus granulosus growth factor receptor bound protein 2 0.0057 0.0965 0.1971
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0065 0.1133 0.2313
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0065 0.1133 0.2313
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0028 0.0369 0.0754
Schistosoma mansoni tyrosine kinase 0.0037 0.0551 0.0932
Schistosoma mansoni thyroid hormone receptor 0.0138 0.264 0.4464
Brugia malayi Fes/CIP4 homology domain containing protein 0.0028 0.0369 0.1192
Echinococcus multilocularis transfer RNA-Ile 0.0247 0.4896 1
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0128 0.2428 0.496
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Onchocerca volvulus 0.0028 0.0369 0.1192
Schistosoma mansoni eps8-related protein 0.0028 0.0369 0.0624
Plasmodium vivax thymidylate kinase, putative 0.014 0.2676 0.8556
Schistosoma mansoni adapter molecule crk 0.0057 0.0965 0.1632
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0535 0.1726
Loa Loa (eye worm) thyroid receptor interactor 0.0028 0.0369 0.1192
Brugia malayi Guanylate kinase family protein 0.0028 0.0369 0.1192
Echinococcus granulosus tensin 0.0029 0.0384 0.0784
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0028 0.0369 0.0754
Leishmania major hypothetical protein, conserved 0.0024 0.0291 0.011
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0525 0.1174
Onchocerca volvulus Putative thymidylate kinase 0.014 0.2676 0.8641
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0369 0.1192
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0711 0.1453
Entamoeba histolytica BAR/SH3 domain containing protein 0.0028 0.0369 0.019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0535 0.1092
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0182 0.0373
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0055 0.0922 0.0753
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0535 0.0805
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0525 0.0349
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.1192
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0065 0.1133 0.2313
Echinococcus granulosus Spectrin alpha actinin 0.0028 0.0369 0.0754
Echinococcus granulosus tyrosine kinase 0.0037 0.0551 0.1126
Schistosoma mansoni hypothetical protein 0.0297 0.5914 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0535 0.1208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0711 0.1453
Brugia malayi Sex muscle abnormal protein 5 0.0057 0.0965 0.3117
Entamoeba histolytica glycogenphosphorylase, putative 0.0046 0.0739 0.0567
Echinococcus multilocularis growth factor receptor bound protein 2 0.0057 0.0965 0.1971
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0711 0.1202
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0525 0.0349
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0029 0.0384 0.0784
Onchocerca volvulus 0.0028 0.0369 0.1192
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0029 0.0384 0.124
Echinococcus multilocularis N chimaerin 0.0029 0.0384 0.0784
Echinococcus multilocularis glycogen phosphorylase 0.0107 0.1987 0.4058
Entamoeba histolytica glycogen phosphorylase, putative 0.0107 0.1987 0.1838
Loa Loa (eye worm) hypothetical protein 0.0036 0.0535 0.1726
Schistosoma mansoni run and tbc1 domain containing 0.0028 0.0369 0.0624
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0525 0.0349
Echinococcus multilocularis thymidylate kinase 0.014 0.2676 0.5466
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0065 0.1133 0.2313
Echinococcus granulosus Glycosyl transferase family 35 0.0107 0.1987 0.4058
Onchocerca volvulus 0.0028 0.0369 0.1192
Schistosoma mansoni ap endonuclease 0.0019 0.0182 0.0309
Echinococcus granulosus suppressor of cytokine signaling 7 0.0029 0.0384 0.0784
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0029 0.0384 0.0784
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0182 0.0373
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0369 0.1192
Schistosoma mansoni tensin 0.0029 0.0384 0.0649
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0029 0.0384 0.0649
Schistosoma mansoni glycogen phosphorylase 0.0107 0.1987 0.3359
Leishmania major hypothetical protein, conserved 0.0055 0.0922 0.0753
Entamoeba histolytica unconventional myosin IB 0.0028 0.0369 0.019
Echinococcus granulosus thymidylate kinase 0.014 0.2676 0.5466
Brugia malayi CXXC zinc finger family protein 0.0029 0.0384 0.1238
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0046 0.0739 0.1908
Echinococcus granulosus SH2 motif 0.0029 0.0384 0.0784
Schistosoma mansoni hypothetical protein 0.0029 0.0384 0.0649
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0046 0.0739 0.1271
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0037 0.0551 0.1126
Brugia malayi Spectrin alpha chain 0.0028 0.0369 0.1192
Trypanosoma cruzi thymidine kinase, putative 0.0495 1 1
Schistosoma mansoni tensin 0.0029 0.0384 0.0649
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0535 0.0805
Trypanosoma brucei thymidylate kinase, putative 0.014 0.2676 0.254
Echinococcus granulosus tyrosine protein kinase Src64B 0.0065 0.1133 0.2313
Trichomonas vaginalis thymidine kinase, putative 0.0495 1 1
Onchocerca volvulus Ribonuclease H1 homolog 0.0043 0.0679 0.2192
Schistosoma mansoni phosphoglucomutase 0.0043 0.0679 0.1148
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0369 0.019
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0014 0.0028
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0028 0.0369 0.0754
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.1133 0.2313
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0535 0.0359
Treponema pallidum thymidylate kinase (tmk) 0.014 0.2676 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.1192
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0525 0.0349
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0535 0.0359
Onchocerca volvulus 0.0029 0.0384 0.124
Trypanosoma brucei ingi protein (ORF1) 0.005 0.0818 0.0647
Giardia lamblia Ribonuclease H 0.0043 0.0679 0.0506
Onchocerca volvulus 0.0037 0.0551 0.178
Schistosoma mansoni thymidine kinase 0.0247 0.4896 0.8278
Brugia malayi SH2 domain containing protein 0.0037 0.0551 0.178
Brugia malayi hypothetical protein 0.0016 0.0113 0.0364
Echinococcus granulosus tyrosine protein kinase Src42A 0.0029 0.0384 0.0784
Brugia malayi Protein kinase domain containing protein 0.0037 0.0551 0.178
Schistosoma mansoni cpg binding protein 0.0029 0.0384 0.0649
Onchocerca volvulus 0.0036 0.0535 0.1726
Onchocerca volvulus 0.0028 0.0369 0.1192
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0065 0.1133 0.2313
Echinococcus multilocularis c src tyrosine kinase 0.0065 0.1133 0.2313
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0291 0.0372
Echinococcus granulosus nostrin 0.0028 0.0369 0.0754
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0028 0.0369 0.0624
Echinococcus granulosus N chimaerin 0.0029 0.0384 0.0784
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0029 0.0384 0.0784
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.1192
Schistosoma mansoni tyrosine kinase 0.0065 0.1133 0.1915
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Mycobacterium tuberculosis Conserved protein 0.0036 0.0535 0.0805
Trypanosoma brucei ingi protein (ORF1) 0.005 0.0818 0.0647
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0535 0.0359
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0028 0.0369 0.0754
Echinococcus multilocularis tyrosine protein kinase Blk 0.0037 0.0551 0.1126
Echinococcus multilocularis thyroid hormone receptor alpha 0.0138 0.264 0.5393
Echinococcus granulosus expressed protein 0.0028 0.0369 0.0754
Echinococcus multilocularis nostrin 0.0028 0.0369 0.0754
Entamoeba histolytica hypothetical protein 0.0028 0.0369 0.019
Echinococcus granulosus thymidine kinase 0.0247 0.4896 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.0551 0.178
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Onchocerca volvulus 0.0028 0.0369 0.1192
Mycobacterium ulcerans beta-lactamase 0.0036 0.0535 0.1208
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0029 0.0384 0.124
Mycobacterium ulcerans thymidylate synthase 0.016 0.3097 1
Schistosoma mansoni glycogen phosphorylase 0.0107 0.1987 0.3359
Brugia malayi thymidylate synthase 0.016 0.3097 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.1192
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Plasmodium falciparum thymidylate kinase 0.014 0.2676 0.8556
Echinococcus multilocularis ribonuclease H1 0.0043 0.0679 0.1387
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0535 0.0359
Entamoeba histolytica hypothetical protein 0.0028 0.0369 0.019
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0037 0.0551 0.1126
Trichomonas vaginalis esterase, putative 0.0036 0.0535 0.0359
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0029 0.0384 0.0649
Entamoeba histolytica hypothetical protein 0.0028 0.0369 0.019
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0029 0.0384 0.0784
Echinococcus granulosus endophilin A3 0.0028 0.0369 0.0754
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0037 0.0551 0.1126
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0535 0.0904
Giardia lamblia Glycogen phosphorylase 0.0107 0.1987 0.1838
Echinococcus multilocularis thymidylate synthase 0.016 0.3097 0.6326
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0525 0.1072
Trichomonas vaginalis ribonuclease H1, putative 0.0043 0.0679 0.0506
Echinococcus granulosus expressed conserved protein 0.0029 0.0384 0.0784
Loa Loa (eye worm) thymidylate kinase 0.014 0.2676 0.8641
Schistosoma mansoni hypothetical protein 0.0128 0.2428 0.4106
Loa Loa (eye worm) hypothetical protein 0.0057 0.0965 0.3117
Schistosoma mansoni hypothetical protein 0.0015 0.0106 0.018
Trichomonas vaginalis thymidylate kinase, putative 0.014 0.2676 0.254
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.1987 0.1838
Trypanosoma brucei RNA helicase, putative 0.0297 0.5914 0.5838
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0369 0.019
Toxoplasma gondii thymidylate kinase 0.014 0.2676 0.8556
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0029 0.0384 0.0784
Leishmania major thymidylate kinase-like protein 0.014 0.2676 0.254
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0029 0.0384 0.0784
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Trichomonas vaginalis glycogen phosphorylase, putative 0.0107 0.1987 0.1838
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0711 0.2296
Mycobacterium ulcerans lipase LipD 0.0036 0.0535 0.1208
Entamoeba histolytica hypothetical protein 0.0028 0.0369 0.019
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.016 0.3097 1
Giardia lamblia Deoxynucleoside kinase 0.0382 0.7682 0.7639
Loa Loa (eye worm) protein-tyrosine kinase 0.0028 0.0369 0.1192
Echinococcus granulosus epidermal growth factor receptor kinase 0.0028 0.0369 0.0754
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.016 0.3097 1
Echinococcus granulosus SH2 motif 0.0029 0.0384 0.0784
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0043 0.0679 0.1991
Echinococcus granulosus intersectin 2 0.0028 0.0369 0.0754
Brugia malayi SRC-1 0.0065 0.1133 0.3657
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1051 0.1777
Echinococcus granulosus GPCR family 2 0.0015 0.0106 0.0217
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0037 0.0551 0.1126
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0711 0.1453
Trichomonas vaginalis thymidine kinase, putative 0.0495 1 1
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0369 0.1192
Echinococcus granulosus tyrosine protein kinase shark 0.0037 0.0551 0.1126
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0535 0.0904
Echinococcus granulosus tyrosine kinase 0.0037 0.0551 0.1126
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.016 0.3097 0.5237
Mycobacterium ulcerans thymidylate kinase 0.014 0.2676 0.8556
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0525 0.0349
Schistosoma mansoni signal transduction protein lnk-related 0.0029 0.0384 0.0649
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.1362 0.1202
Entamoeba histolytica protein kinase, putative 0.0028 0.0369 0.019
Schistosoma mansoni vav2 0.0029 0.0384 0.0649
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0028 0.0369 0.0624
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.1192
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0029 0.0384 0.124
Schistosoma mansoni tensin 0.0029 0.0384 0.0649
Onchocerca volvulus 0.0029 0.0384 0.124
Onchocerca volvulus 0.0029 0.0384 0.1238
Schistosoma mansoni sorting nexin 0.0028 0.0369 0.0624
Brugia malayi carbohydrate phosphorylase 0.0107 0.1987 0.6415
Schistosoma mansoni C-fyn 0.0028 0.0369 0.0624
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0537 0.0907
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0106 0.0343
Trypanosoma cruzi ribonuclease H1, putative 0.0043 0.0679 0.0506
Echinococcus granulosus NCK adaptor protein 0.0057 0.0965 0.1971
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0247 0.4896 1
Echinococcus multilocularis SH2 motif 0.0029 0.0384 0.0784
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0028 0.0369 0.0754
Loa Loa (eye worm) SRC-1 0.0065 0.1133 0.3657
Brugia malayi RNase H family protein 0.0043 0.0679 0.2192
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0028 0.0369 0.0754
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0535 0.0359
Trypanosoma cruzi thymidine kinase, putative 0.0495 1 1
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0028 0.0369 0.1192
Echinococcus multilocularis expressed protein 0.0028 0.0369 0.0754
Trypanosoma brucei unspecified product 0.005 0.0818 0.0647
Echinococcus multilocularis tensin 0.0029 0.0384 0.0784
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0291 0.0372
Brugia malayi cytokine inducible SH2-containing protein 5 0.0029 0.0384 0.124
Schistosoma mansoni ap endonuclease 0.0019 0.0182 0.0309
Echinococcus multilocularis Spectrin alpha actinin 0.0028 0.0369 0.0754
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0369 0.019
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0029 0.0384 0.0784
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Loa Loa (eye worm) SH2 domain-containing protein 0.0029 0.0384 0.124
Brugia malayi hypothetical protein 0.0024 0.0291 0.0939
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.1192
Entamoeba histolytica hypothetical protein 0.0028 0.0369 0.019
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.014 0.2676 0.8412
Trypanosoma brucei conserved protein 0.0028 0.0369 0.019
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0106 0.0343
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0535 0.0329
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0029 0.0384 0.0784
Onchocerca volvulus 0.016 0.3097 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0739 0.0567
Giardia lamblia Thymidine kinase 0.0495 1 1
Entamoeba histolytica hypothetical protein 0.0028 0.0369 0.019
Brugia malayi hypothetical protein 0.0076 0.1362 0.4398
Echinococcus granulosus thymidine kinase 0.0247 0.4896 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.016 0.3097 0.2969
Schistosoma mansoni apoptosis stimulating of P53 0.0028 0.0369 0.0624
Schistosoma mansoni hypothetical protein 0.0015 0.0106 0.018
Echinococcus multilocularis transfer RNA-Ala 0.0028 0.0369 0.0754
Loa Loa (eye worm) beta-lactamase 0.0036 0.0535 0.1726
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0106 0.0217
Trypanosoma brucei thymidylate kinase, putative 0.014 0.2676 0.254
Brugia malayi Peripheral plasma membrane protein CASK 0.0028 0.0369 0.1192
Loa Loa (eye worm) TK/ABL protein kinase 0.0037 0.0551 0.178
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Echinococcus granulosus tyrosine protein kinase Src42A 0.0065 0.1133 0.2313
Schistosoma mansoni cell polarity protein 0.0028 0.0369 0.0624
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0711 0.2296
Mycobacterium tuberculosis Hypothetical protein 0.0076 0.1362 0.2696
Leishmania major dihydrofolate reductase-thymidylate synthase 0.016 0.3097 0.2969
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0535 0.0805
Trichomonas vaginalis thymidylate kinase, putative 0.014 0.2676 0.254
Schistosoma mansoni inositol monophosphatase 0.0036 0.0525 0.0887
Loa Loa (eye worm) guanylate kinase 0.0028 0.0369 0.1192
Brugia malayi Variant SH3 domain containing protein 0.0057 0.0965 0.3117
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0028 0.0369 0.0624
Echinococcus granulosus cpg binding protein 0.003 0.0418 0.0853
Chlamydia trachomatis thymidylate kinase 0.014 0.2676 1
Brugia malayi SH2 domain containing protein 0.0029 0.0384 0.124
Trypanosoma cruzi thymidylate kinase, putative 0.014 0.2676 0.254
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Schistosoma mansoni hypothetical protein 0.014 0.2676 0.4525
Echinococcus granulosus glycogen phosphorylase 0.0107 0.1987 0.4058
Mycobacterium tuberculosis Conserved protein 0.0036 0.0535 0.0805
Loa Loa (eye worm) SH2 domain-containing protein 0.0029 0.0384 0.124
Onchocerca volvulus 0.0029 0.0384 0.124
Echinococcus multilocularis thymidine kinase 0.0247 0.4896 1
Loa Loa (eye worm) thymidylate synthase 0.016 0.3097 1
Onchocerca volvulus 0.0036 0.0535 0.1726
Schistosoma mansoni cpg binding protein 0.003 0.0418 0.0706
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0794 0.2564
Brugia malayi protein-tyrosine kinase 0.0028 0.0369 0.1192
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0029 0.0384 0.0784
Echinococcus multilocularis tyrosine protein kinase Abl 0.0065 0.1133 0.2313
Trypanosoma cruzi thymidylate kinase, putative 0.014 0.2676 0.254
Schistosoma mansoni suppressor of cytokine signaling 0.0029 0.0384 0.0649
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0029 0.0384 0.0649
Brugia malayi SH2 domain containing protein 0.0029 0.0384 0.124
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0525 0.0349
Entamoeba histolytica glycogen phosphorylase, putative 0.0046 0.0739 0.0567
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0535 0.1092
Echinococcus granulosus thymidylate synthase 0.016 0.3097 0.6326
Echinococcus granulosus signal transduction protein lnk realted 0.0029 0.0384 0.0784
Schistosoma mansoni growth factor receptor-bound protein 0.0057 0.0965 0.1632
Schistosoma mansoni growth factor receptor-bound protein 0.0057 0.0965 0.1632
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0029 0.0384 0.0784
Toxoplasma gondii ribonuclease HI protein 0.0043 0.0679 0.1703
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0029 0.0384 0.0784
Brugia malayi Variant SH3 domain containing protein 0.0057 0.0965 0.3117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0711 0.1202
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Schistosoma mansoni GTPase activating protein 0.0029 0.0384 0.0649
Loa Loa (eye worm) hypothetical protein 0.0028 0.0369 0.1192
Loa Loa (eye worm) TK protein kinase 0.0037 0.0551 0.178
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0014 0.0028
Brugia malayi Variant SH3 domain containing protein 0.0029 0.0384 0.124
Loa Loa (eye worm) hypothetical protein 0.0036 0.0535 0.1726
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0037 0.0551 0.0376
Loa Loa (eye worm) glycogen phosphorylase 0.0107 0.1987 0.6415
Brugia malayi RNase H family protein 0.0043 0.0679 0.2192
Brugia malayi RhoGAP domain containing protein 0.0029 0.0384 0.124
Echinococcus multilocularis 0.0029 0.0384 0.0784
Schistosoma mansoni hypothetical protein 0.0029 0.0384 0.0649
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0794 0.2564
Onchocerca volvulus 0.0037 0.0551 0.178
Schistosoma mansoni tyrosine kinase 0.0037 0.0551 0.0932
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0029 0.0384 0.0649
Brugia malayi Protein kinase domain containing protein 0.0037 0.0551 0.178
Entamoeba histolytica BAR/SH3 domain containing protein 0.0028 0.0369 0.019
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0106 0.0217
Echinococcus granulosus tyrosine protein kinase Fyn 0.0065 0.1133 0.2313
Toxoplasma gondii ABC1 family protein 0.0036 0.0535 0.1208
Loa Loa (eye worm) STAT protein 0.0029 0.0384 0.124
Echinococcus multilocularis SH2 motif 0.0029 0.0384 0.0784
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0057 0.0965 0.3117
Schistosoma mansoni Dab2-interacting protein-like 0.0028 0.0369 0.0624
Echinococcus granulosus tyrosine protein kinase Blk 0.0037 0.0551 0.1126
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0028 0.0369 0.1192
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0028 0.0369 0.0754
Schistosoma mansoni hypothetical protein 0.0033 0.0476 0.0804
Onchocerca volvulus 0.0036 0.0535 0.1726
Trypanosoma brucei thymidine kinase 0.0495 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0369 0.019
Leishmania major hypothetical protein, conserved 0.0028 0.0369 0.019
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0535 0.1208
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0369 0.019
Schistosoma mansoni dynamin-associated protein 0.0028 0.0369 0.0624
Onchocerca volvulus 0.0037 0.0551 0.178
Giardia lamblia CDC8 0.014 0.2676 0.254
Echinococcus multilocularis tyrosine protein kinase Srms 0.0037 0.0551 0.1126
Brugia malayi Tensin 0.0029 0.0384 0.124
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0535 0.1726
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0711 0.1453
Loa Loa (eye worm) SH2 domain-containing protein 0.0029 0.0384 0.124
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0106 0.0217
Loa Loa (eye worm) hypothetical protein 0.0036 0.0535 0.1726
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0291 0.011
Schistosoma mansoni sorbin 0.0028 0.0369 0.0624
Echinococcus granulosus suppressor of cytokine signaling 6 0.0029 0.0384 0.0784
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0535 0.0805
Schistosoma mansoni hypothetical protein 0.0015 0.0106 0.018
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0551 0.178
Onchocerca volvulus 0.0037 0.0551 0.178
Brugia malayi Src substrate cortactin 0.0028 0.0369 0.1192
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.014 0.2676 0.5699
Echinococcus granulosus tyrosine protein kinase ABL1 0.0037 0.0551 0.1126
Leishmania major ribonuclease H1, putative 0.0043 0.0679 0.0506
Onchocerca volvulus 0.0029 0.0384 0.124
Echinococcus granulosus tyrosine protein kinase Lyn 0.0065 0.1133 0.2313
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0369 0.019
Schistosoma mansoni phosphoglucomutase 0.0043 0.0679 0.1148
Echinococcus multilocularis Glycosyl transferase, family 35 0.0107 0.1987 0.4058
Loa Loa (eye worm) hypothetical protein 0.0015 0.0106 0.0343
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0028 0.0369 0.0754
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0028 0.0369 0.0754
Echinococcus granulosus SH2 domain containing protein 7 0.0029 0.0384 0.0784
Loa Loa (eye worm) hypothetical protein 0.0029 0.0384 0.124
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0535 0.0359
Brugia malayi Variant SH3 domain containing protein 0.0028 0.0369 0.1192
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0291 0.0372
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0029 0.0384 0.0784
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0029 0.0384 0.124
Entamoeba histolytica hypothetical protein, conserved 0.0028 0.0369 0.019
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.014 0.2676 1
Schistosoma mansoni formin binding protein and related proteins 0.0028 0.0369 0.0624
Schistosoma mansoni hypothetical protein 0.0028 0.0369 0.0624
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0535 0.1208
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0106 0.0217
Brugia malayi Myosin tail family protein 0.0028 0.0369 0.1192
Echinococcus granulosus src region 0.0028 0.0369 0.0754
Brugia malayi protein-tyrosine kinase 0.0037 0.0551 0.178
Schistosoma mansoni phosphoglucomutase 0.0043 0.0679 0.1148
Schistosoma mansoni suppressor of cytokine signaling 0.0029 0.0384 0.0649

Activities

Activity type Activity value Assay description Source Reference
ILS (functional) = 41.3 % Percent increase in life span at dose 3 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 48.3 % Percent increase in life span at dose 9 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 64 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intravenouslly at a dose of 7 mg/kg per day ChEMBL. 4020828
ILS (functional) = 65.7 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intravenouslly at a dose of 6 mg/kg per day ChEMBL. 4020828
ILS (functional) = 66.5 % Percent increase in life span at dose 5 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 117.6 % Percent increase in life span at dose 6 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 149 % Percent increase in life span at dose 8 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 164 % Percent increase in life span at dose 7 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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