TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.247 | Formula: C19H15Cl2N3O2
H donors: 1 H acceptors: 2 LogP: 4.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1Cl)CNc1nccc(n1)c1ccc2c(c1)OCCO2
InChi: 1S/C19H15Cl2N3O2/c20-14-3-1-12(9-15(14)21)11-23-19-22-6-5-16(24-19)13-2-4-17-18(10-13)26-8-7-25-17/h1-6,9-10H,7-8,11H2,(H,22,23,24)
InChiKey: INAVVYMHODCJNF-UHFFFAOYSA-N

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	CDC-like kinase 2	Starlite/ChEMBL	References
Homo sapiens	CDC-like kinase 3	Starlite/ChEMBL	References
Homo sapiens	CDC-like kinase 4	Starlite/ChEMBL	References
Homo sapiens	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	Starlite/ChEMBL	References
Homo sapiens	CDC-like kinase 1	Starlite/ChEMBL	References
Homo sapiens	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	CMGC/CLK protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus multilocularis	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	kinetoplastid kinetochore protein 19	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium falciparum	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Cryptosporidium hominis	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Babesia bovis	protein serine/threonine kinase 1	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium vivax	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania donovani	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma japonicum	ko:K08823 CDC-like kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Theileria parva	serine/threonine protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium yoelii	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis		Get druggable targets OG5_126990	All targets in OG5_126990
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Cryptosporidium parvum	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase minibrain, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Giardia lamblia	Kinase, CMGC CLK	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium berghei	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	kinetoplastid kinetochore protein 10	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase Doa, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium knowlesi	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus multilocularis	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania mexicana		Get druggable targets OG5_126990	All targets in OG5_126990

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	dehydrogenase/decarboxylase protein	0.0009	0	0.5
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0293	1	1
Mycobacterium leprae	Possible short-chain dehydrogenase EphD	0.0009	0	0.5
Mycobacterium leprae	Probable oxidoreductase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0167	0.5566	0.5566
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0003	0.0003
Mycobacterium tuberculosis	Possible oxidoreductase	0.0009	0	0.5
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0003	0.0003
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0865	0.0865
Mycobacterium tuberculosis	Possible oxidoreductase	0.0009	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0218	0.7348	0.7348
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0003	0.0003
Mycobacterium tuberculosis	Probable oxidoreductase	0.0009	0	0.5
Brugia malayi	Smad1	0.0009	0.0003	0.0003
Echinococcus granulosus	hypothetical protein	0.029	0.9883	0.9883
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0218	0.7348	1
Echinococcus multilocularis	Smad4	0.0009	0.0003	0.0003
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0865	0.0865
Mycobacterium tuberculosis	Possible ketoacyl reductase	0.0009	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0865	0.0865
Brugia malayi	MH1 domain containing protein	0.0009	0.0003	0.0003
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0009	0	0.5
Schistosoma mansoni	hypothetical protein	0.0054	0.1588	0.1588
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium ulcerans	ketoacyl reductase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0822	0.0822
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0293	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0009	0	0.5
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0054	0.1588	0.1588
Mycobacterium ulcerans	short-chain dehydrogenase	0.0009	0	0.5
Brugia malayi	Pre-SET motif family protein	0.0233	0.7876	0.7876
Mycobacterium tuberculosis	Probable short chain alcohol dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0218	0.7348	0.7348
Brugia malayi	MH2 domain containing protein	0.0009	0.0003	0.0003
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0755	0.0755
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0009	0	0.5
Mycobacterium leprae	ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE	0.0009	0	0.5
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0003	0.0003
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0218	0.7348	0.7348
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0293	1	1
Trichomonas vaginalis	CMGC family protein kinase	0.0293	1	1
Mycobacterium ulcerans	oxidoreductase	0.0009	0	0.5
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0233	0.7876	0.7876
Echinococcus granulosus	dual specificity	0.0218	0.7348	0.7348
Mycobacterium ulcerans	short-chain dehydrogenase	0.0009	0	0.5
Loa Loa (eye worm)	Smad1	0.0009	0.0003	0.0003
Entamoeba histolytica	protein kinase domain containing protein	0.0218	0.7348	1
Mycobacterium tuberculosis	Possible short-chain dehydrogenase EphD	0.0009	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable dehydrogenase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Echinococcus multilocularis	muscleblind protein 1	0.0167	0.5566	0.5566
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0009	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium leprae	Probable short-chain type dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0003	0.0003
Echinococcus multilocularis	smad	0.0009	0.0003	0.0003
Mycobacterium ulcerans	ketoacyl reductase	0.0009	0	0.5
Entamoeba histolytica	hypothetical protein	0.0218	0.7348	1
Mycobacterium ulcerans	short-chain dehydrogenase	0.0009	0	0.5
Mycobacterium ulcerans	short-chain type oxidoreductase	0.0009	0	0.5
Echinococcus granulosus	survival motor neuron protein 1	0.0264	0.8991	0.8991
Plasmodium vivax	serine/threonine kinase-1, putative	0.0293	1	1
Loa Loa (eye worm)	hypothetical protein	0.029	0.9883	0.9883
Schistosoma mansoni	serine/threonine protein kinase	0.0293	1	1
Mycobacterium tuberculosis	Probable short-chain type oxidoreductase	0.0009	0	0.5
Leishmania major	protein kinase, putative	0.0293	1	1
Onchocerca volvulus		0.0265	0.9007	1
Brugia malayi	hypothetical protein	0.0264	0.8991	0.8991
Mycobacterium ulcerans	short-chain dehydrogenase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Brugia malayi	Muscleblind-like protein	0.0167	0.5566	0.5566
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0865	0.0865
Schistosoma mansoni	smad	0.0009	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0167	0.5566	0.5566
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0218	0.7348	0.7348
Echinococcus granulosus	muscleblind protein	0.0167	0.5566	0.5566
Giardia lamblia	Kinase, CMGC CLK	0.0293	1	1
Mycobacterium ulcerans	short-chain membrane-associated dehydrogenase	0.0009	0	0.5
Mycobacterium tuberculosis	Possible fatty acyl-CoA reductase	0.0009	0	0.5
Mycobacterium tuberculosis	Possible iron-regulated short-chain dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Brugia malayi	MH1 domain containing protein	0.0009	0.0003	0.0003
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0009	0	0.5
Echinococcus multilocularis		0.029	0.9883	0.9883
Loa Loa (eye worm)	hypothetical protein	0.0264	0.8991	0.8991
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Echinococcus granulosus	smad	0.0009	0.0003	0.0003
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0009	0	0.5
Mycobacterium ulcerans	oxidoreductase	0.0009	0	0.5
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0865	0.0865
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0293	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0009	0	0.5
Brugia malayi	Cytochrome P450 family protein	0.003	0.0755	0.0755
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0293	1	1
Mycobacterium ulcerans	carveol-like dehydrogenase	0.0009	0	0.5
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0293	1	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Onchocerca volvulus		0.0054	0.1588	0.1763
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0009	0	0.5
Schistosoma mansoni	Smad4	0.0009	0.0003	0.0003
Plasmodium falciparum	protein serine/threonine kinase-1	0.0293	1	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Trichomonas vaginalis	set domain proteins, putative	0.0265	0.9007	0.9007
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0003	0.0003
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0218	0.7348	0.7348
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0003	0.0003
Loa Loa (eye worm)	transcription factor SMAD2	0.013	0.4274	0.4274
Mycobacterium tuberculosis	Decaprenylphosphoryl-D-2-keto erythro pentose reductase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0865	0.0865
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium tuberculosis	Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Echinococcus granulosus	dual specificity protein kinase clk2	0.0293	1	1
Brugia malayi	MH2 domain containing protein	0.013	0.4274	0.4274
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0003	0.0003
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0865	0.0865
Mycobacterium ulcerans	dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium ulcerans	dehydrogenase	0.0009	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0218	0.7348	0.7348
Mycobacterium leprae	PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE	0.0009	0	0.5
Echinococcus granulosus	Smad4	0.0009	0.0003	0.0003
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0218	0.7348	0.7348
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0293	1	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0865	0.0865
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0009	0	0.5
Brugia malayi	MH2 domain containing protein	0.0009	0.0003	0.0003
Echinococcus multilocularis	muscleblind protein	0.0167	0.5566	0.5566
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Leishmania major	protein kinase, putative	0.0293	1	1
Loa Loa (eye worm)	hypothetical protein	0.0214	0.7231	0.7231
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0003	0.0003
Mycobacterium tuberculosis	Probable short-chain dehydrogenase/reductase	0.0009	0	0.5
Loa Loa (eye worm)	MH2 domain-containing protein	0.013	0.4274	0.4274
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0009	0	0.5
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0865	0.0865
Echinococcus multilocularis	survival motor neuron protein 1	0.0264	0.8991	0.8991
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0293	1	1
Echinococcus multilocularis	dual specificity	0.0218	0.7348	0.7348
Mycobacterium tuberculosis	Probable oxidoreductase	0.0009	0	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0009	0	0.5
Entamoeba histolytica	protein kinase, putative	0.0218	0.7348	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0293	1	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0009	0	0.5
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0293	1	1
Mycobacterium ulcerans	ketoacyl reductase	0.0009	0	0.5
Mycobacterium tuberculosis	Probable shortchain dehydrogenase	0.0009	0	0.5
Schistosoma mansoni	survival motor neuron protein	0.0054	0.1588	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0214	0.7231	0.7231
Onchocerca volvulus		0.0033	0.0865	0.096
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0003	0.0003
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5
Brugia malayi	Pre-SET motif family protein	0.0033	0.0865	0.0865
Plasmodium vivax	SET domain protein, putative	0.0033	0.0865	0.0865
Mycobacterium ulcerans	short chain dehydrogenase	0.0009	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (binding)	= 0.0206 uM	PUBCHEM_BIOASSAY: MLPCN Dyrk1A - CLK1 Selectivity Assay Measured in Biochemical System Using Plate Reader - 2124-05_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504442]	ChEMBL.	No reference
IC50 (binding)	= 13 nM	Inhibition of CLK4 (unknown origin)	ChEMBL.	23642479
IC50 (binding)	= 16 nM	Inhibition of CLK1 (unknown origin)	ChEMBL.	23642479
IC50 (binding)	= 18 nM	Inhibition of DYRK1A (unknown origin)	ChEMBL.	23642479
IC50 (binding)	= 39 nM	Inhibition of CLK2 (unknown origin)	ChEMBL.	23642479
IC50 (binding)	= 55 nM	Inhibition of DYRK1B (unknown origin)	ChEMBL.	23642479
IC50 (binding)	= 120 nM	Inhibition of CLK4 (unknown origin) by bioluminescence assay	ChEMBL.	23642479
IC50 (binding)	= 210 nM	Inhibition of DYRK1A (unknown origin) by bioluminescence assay	ChEMBL.	23642479
IC50 (binding)	> 10000 nM	Inhibition of CLK3 (unknown origin)	ChEMBL.	23642479

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1904905

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1551894